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<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM96</accession>
    <name>B0XM96_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_000300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM96"/>
    <dbReference type="SMR" id="B0XM96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000300"/>
    <dbReference type="HOGENOM" id="CLU_083054_0_0_1"/>
    <dbReference type="OrthoDB" id="2923349at2759"/>
    <dbReference type="PhylomeDB" id="B0XM96"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002759962" description="TNT domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="120"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="234" mass="26022" checksum="6363C1F09E3008AD" modified="2008-04-08" version="1">MIFTNAILVISALLPATVLSLQHTEDSLFPARCWPDPCAGITFQNDTYVCGDPRLGPVVLPQKFPLNNELRTYARFGALCPAEFLDKWATDVAPNGTYIYPPANGFALDTEEQPILGNATLPVGMKLDRFGSEYGTFLAPLGAPYIERSLPPSNLNTFDGMYPYNYHVYQVTKEFVVGLGPIAPWFEQPGMGTQFVTYTNVLGLIDDGYLRRLDESEYDEKVEYSNPYTPGPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMD3</accession>
    <name>B0XMD3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_000670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000670"/>
    <dbReference type="HOGENOM" id="CLU_1156138_0_0_1"/>
    <dbReference type="OrthoDB" id="4509772at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760327" evidence="2">
        <location>
            <begin position="30"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="240" mass="24049" checksum="FFA1266123B8613F" modified="2008-04-08" version="1">MATQRKAKASLLDLIFLVDMISFSSLVGARPLPWTSTGASGSDTAASSGTPTSWGGSGGSSFASASPGIKVSGSWAPGNAGEVSDTGTKANSSGFSSSSSGSSAMAGFGVGSEDAASKGSARSNNGTTGAGTGDAGYGSDVLRRFPAVVEHLPRPDQQNAERPKGPTTMYLHIPRDRLKPTRSVGGGNTSNGVNGGATNTGSGTNVNVITSPANGGEKRKGQRDHQYASRQAGLIIKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XME4</accession>
    <name>B0XME4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_001430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XME4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001430"/>
    <dbReference type="HOGENOM" id="CLU_042829_1_1_1"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000010">
        <property type="entry name" value="G/U mismatch-specific DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="6">
        <location>
            <begin position="302"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="497" mass="54764" checksum="26770DC3C7AB7990" modified="2008-04-08" version="1">MGRLIKNHWARLIVLTAAAYQIGSAVEGFIWPKIFWDFTTRNLNGAVKPTPILQILNLIMGLLGIAWEWPLNLLAGTLPHRSIEVRLIMYPLSALLAALLYQGTNPAIYYLIGIAVYFWAYTEGEKRSSSTASMSRPASVAEDISQGYQDEAGTDDENDVPVNKKTSFNGRLNQYFHASKNVAPTGESLSKVASAPDLPTATIKRKPESDSEPPSDPSSNASALQLPIKRPRTLRSSRSSPVITNLTPRITRSRSASSTTSLPPSTPNSPLTPSTTPDEISRSRSRRRQPSTPATSSICLLRDTIPPNLTLLLVGVNPGIMTGTTGFAYAHPSNLFWKLLHWSGITPIRHPPSDTYRLPELYNIGNTNIVERPTRDASMLSKAEMNAGVPVLEAKVAKQRPEAVCLVGKSIWEAVWRVRKGRPIRKEEFRYGWQDETENMGRCDGPDGWEGARVFVATTTSGLAAGMSIAEKQAVWNELGRWVIQRREALAGKRPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN65</accession>
    <name>B0XN65_ASPFC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_014740</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1602308_0_0_1"/>
    <dbReference type="OrthoDB" id="10568010at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="166" mass="18008" checksum="B6D72CC4E066DFC2" modified="2008-04-08" version="1">MVMEPFGGAGLKTIYHQYIICQVTDITACSVHSNNPGFCAATASTKLAQSALAAIPSHDIVWVVWSKLIVELVGFELGIVERRDGLLEDHPFPCCSESVDNFLLKAVQAEDLRPKPKPEPGLTLSVLCTAATDWVLRIPSQVISAMDSLMLWKSTLHGIESESSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">AFUB_006080</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_005382_2_1_1"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="PhylomeDB" id="B0XP64"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="392"/>
        </location>
    </feature>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="531" mass="58057" checksum="A92E7CAA1BA98265" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQE1</accession>
    <name>B0XQE1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_009630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009630"/>
    <dbReference type="HOGENOM" id="CLU_013056_1_0_1"/>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP56255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="741" mass="83444" checksum="B0BA8FABA9228F98" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQJ5</accession>
    <name>B0XQJ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCAAT-box-binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_010180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010180"/>
    <dbReference type="HOGENOM" id="CLU_003417_0_0_1"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="PhylomeDB" id="B0XQJ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="649"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="966"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123989" checksum="F5A0F1739F06DE17" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRN1</accession>
    <name>B0XRN1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_013260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRN1"/>
    <dbReference type="SMR" id="B0XRN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013260"/>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="PhylomeDB" id="B0XRN1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="14">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP56615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="103" mass="11370" checksum="9392CDB8AE0C52E2" modified="2008-04-08" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKTFLEGVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRW4</accession>
    <name>B0XRW4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_025060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025060"/>
    <dbReference type="HOGENOM" id="CLU_086803_0_0_1"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="PhylomeDB" id="B0XRW4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760557" description="Coatomer subunit zeta" evidence="13">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="201" mass="21929" checksum="AEFE8870C0E7B80F" modified="2008-04-08" version="1">MVGSLSLFSVNAVLLMSADDGSRIFAKYYSPPHPPAGAAPNATDYPGANPYPTLKDQKAFEQGLLEKTNKQTSDVILYDNRVVVFKMESDVMIYVVGGADENEVLLYNVVLSLRDALGILFKGATDKRTIVENYDLVALAIDEIIDDGIILETDPVMVASRVSRAPAPDAPNLKSIDLSEQGLLNAWELGKRRLAEGLRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSQ7</accession>
    <name>B0XSQ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione-dependent formaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_017250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017250"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="PhylomeDB" id="B0XSQ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="46"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="436" mass="47968" checksum="EA6AF7DBB497C58E" modified="2008-04-08" version="1">MSTSITTHVSNYGEKHGDPSQTMKALTWQGNRTVKVETAIPKIIDPGDAIVKVTGSTICGSDLHLYHGAIPELQKGDILGHEFCGIVVTVGQGVQKVKVGDRVVASFQIACGQCYYCKQGLPTMCERTNTGESATRLYGHRMSGFFGYSHFTGGFAGGLSEFVRVPYGDVNLLNLPDDVPDEKGLYLSDVLGTSWNAVVDTGVKEGNTVAIWGAGPVGQMAAEYSFFHGAKRVILIDGGQGKWRLDFIKKILPKLETIDFANLPKGESVPSTLKKMCDGHGPDVAIECAAGEYEKGWAHYFQRLLGMETDTSELVNEMLMSVRGFGHCGITGVYAGYVRGTFFMCNHFNIGALMECGIKLHGNGQAPVQKYWKELLRYIQEDKIHPLDMVTHRFKLEDMEKVYDLFDKREQGMQKVFIQTRFSAPPSPGSRPLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTC8</accession>
    <name>B0XTC8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_028960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTC8"/>
    <dbReference type="SMR" id="B0XTC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028960"/>
    <dbReference type="HOGENOM" id="CLU_104368_2_0_1"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="PhylomeDB" id="B0XTC8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP54837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="151" mass="16623" checksum="AB047E14A33820E1" modified="2008-04-08" version="1">MPTLNYPDSSPLKPAELQVLRAQYEKEGDYVGIQTKFNYAWGLIKSNARTDQQEGVRLLSEIFRAAPERRRECLYYLALGNYKLGNYGEARRYNDLLLEKEPGNLQAASLGSLIDDKVSKEGLMGIAIVGGLALAAGIVGGLVFKGAAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTN9</accession>
    <name>B0XTN9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2 finger domain protein FlbC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_029400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029400"/>
    <dbReference type="HOGENOM" id="CLU_036835_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="PhylomeDB" id="B0XTN9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001278">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="355" mass="38227" checksum="6836E80210705EFF" modified="2008-04-08" version="1">MTMVIENQNRQYGGMSFDSVYSHNVAHHAPQFTDPWTSAHTSSHSTPPVYATSMGINHTKPEEVSRPTLSMPYSSVPVSAPSMVTSGNFSTAPTGYSGAEVIGLQHDMPRTTFEQAPTYTTASSMSSFTPATYAPISYAPPLAHPHPDSRRVSHVDPRGNHSQPPSGPTFGDALDASRGMVALSQDLTPRNIYAPRARGSGDSYGFPAAHSSGSSISSGGNYPYYSASVASVESSVTDYSSTTSESYENGHLSRTLPRPSNLLSGSAPPGPQSMMSQFSSKMPSNTQKKHKCKVCDKRFTRPSSLQTHMYSHTGEKPFACDVEGCGRHFSVVSNLRRHKKVHKGEKENVSGGEEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU32</accession>
    <name>FAEC_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable feruloyl esterase C</fullName>
            <ecNumber>3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ferulic acid esterase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">faeC</name>
        <name type="ORF">AFUB_030150</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the faeC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU32"/>
    <dbReference type="SMR" id="B0XU32"/>
    <dbReference type="ESTHER" id="aspfu-faec">
        <property type="family name" value="FaeC"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP54955">
        <property type="protein sequence ID" value="EDP54955"/>
        <property type="gene ID" value="AFUB_030150"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030150"/>
    <dbReference type="HOGENOM" id="CLU_027551_2_0_1"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="PhylomeDB" id="B0XU32"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394937" description="Probable feruloyl esterase C">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="272" mass="28770" checksum="3A19B42A21F75DC0" modified="2008-04-08" version="1" precursor="true">MVPTIIYSAILALSAFTPSVFAQTRSSGCGKQPSLANGVHNINGREYILKVPDNYDKNKAHHLVFGLHWRGGNMWNIVDGQSIQPWYGLETRAQGSAIFVAPNGKNAGWANYGGEDIAFIDAIIKQVESDLCVDQSSRFATGFSWGGGMSYSLACSRAKQFKAVSVLSGGVISGCDGGNDPIAYLGIHGINDGVLPFQGGVNLAQKFVRNNGCQQSNVGTPQPGSRGSVRTDFKGCSKPVSFIAYDGGHDAAPLGVGSSLAPDATWRFFMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU48</accession>
    <name>B0XU48_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP transcription factor FlbB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_030320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030320"/>
    <dbReference type="HOGENOM" id="CLU_036934_1_0_1"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="PhylomeDB" id="B0XU48"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000110">
        <property type="entry name" value="BZIP-type transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43216" checksum="C95B78FE95F0F18E" modified="2008-04-08" version="1">MSTNFFQFFGGQKKVTRDGQPAKRRGPKPDSRPALTRRQELNRQAQRTHRERKEQYIRSLEIEVSRLREAFTQEMSAANLAVVQHREMLQTVNDENAILKELLTAHGIQFEAELERRRAERRSAGRGFQSSPLAGSSVVSQAPAALAASDGNTYTTPPTTVSNVSTDVSPLANGMERVEISPTHEITPPPPIAMTASSCEIPADLDLSAIARNQEPVQAVGGVFEADPQLQIDFILTLESPCREHTDYLCRRSITEADDEDMPFSGHALMATCPPPSYIANTTPEQAYPHKTYDLPHANLTTLLNLSRQLVTEGQITPIMALQCLKNHELYRTLTKDDVKIIIETLNTKVRCYGFGAVVEDFELMDCLSSVLGSKVDTSFSCAGDDTMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUE1</accession>
    <name>B0XUE1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF652 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_020410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020410"/>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="PhylomeDB" id="B0XUE1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="192" mass="21900" checksum="C482B5961EA94E25" modified="2008-04-08" version="1">MGIAKKTRKFAQVKRAISQRDNRVNQPLNGKKEEKKPQGEELVRHIPVAPSNMFFAANTALGPPYTVLVDTNFVSHTIRAKLDMLPAMMDLLYAKCIPTFTDCTIAELEKLGPKFRLALRVAKDPRWNRLHCDHAGTYADDCIVDRVMKHRIYTVATNDKDLVRRIRKIPGVPIMKVARGKYVIERLPDSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUV2</accession>
    <name>B0XUV2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitotic spindle checkpoint protein (Mad2B), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_031540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031540"/>
    <dbReference type="HOGENOM" id="CLU_050394_1_0_1"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="PhylomeDB" id="B0XUV2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000005">
        <property type="entry name" value="Mitotic spindle checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="32"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="290" mass="31833" checksum="C48B0792625D06C8" modified="2008-04-08" version="1">MPIASESSTTTTTMTTFSAPVTVPMSMPNNQSALAASFTNFLTVSIHQILFLRSVYPRATFLPVRAYNYPVRQSRHPKVCDYINDASIAVGTEILKGTITAVSIIISSLRTNQPLERYAFDLSGFPRVSAGDVNTTFEDRSEDSSKPGVPVPDRGSAPTTVDLEAQFRACLARLASACARLTPLPRDDEFSFTVCIEVREDALPPAGTTKEEQTWIVAEPGKIHLRSCTAPYSVSKSKNGDLHQLPPKVSNGRAKTVPVRRVEAGELRLELWVEEARQKFNEPVDSEHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV26</accession>
    <name>B0XV26_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LaeA-like methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_021420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021420"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_6_1"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="PhylomeDB" id="B0XV26"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="296" mass="32976" checksum="CB10D43CD6AC746C" modified="2008-04-08" version="1">MASPSDAAYLLGRDPEESKRLNAQHAFLVDVIGGTPIHPSIPTANIRSIADAATGTGIWLVDAAQTLHNHHPRHTLSLHGFDISPAQFPFSSLKAQRHEIQLTVQDILQPFPQEHRGRYDLVHVRLLVGALKEVDYPRAVRNLYDLLKPGGYLQWDDCDTTAFCTDDPTPIDMEMRQIVVDAVEKLGLCGYAPQYLHQLAAQTGFVDARLYANSTADKPHLRGPARTWLMQVLRALMPHAMIKSGEVVDEKKAIERAERLVEEFGRHCTAALPLVNLYVLVARKPVRPRSGCCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW64</accession>
    <name>B0XW64_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-ornithine N(5)-monooxygenase</fullName>
            <ecNumber evidence="5">1.14.13.196</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">L-ornithine N(5)-oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_023720</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="5"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW64"/>
    <dbReference type="SMR" id="B0XW64"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023720"/>
    <dbReference type="HOGENOM" id="CLU_020931_2_0_1"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="PhylomeDB" id="B0XW64"/>
    <dbReference type="PHI-base" id="PHI:7333"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000195">
        <property type="entry name" value="L-ornithine N(5)-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="501" mass="56877" checksum="DD1D4DEDD2509506" modified="2008-04-08" version="1">MESVERKSESSYLGMRNMQPEQRLSLDPPRLRSTPQDELHDLLCVGFGPASLAIAIALHDALDPRLNKSASNIHAQPKICFLERQKQFAWHSGMLVPGSKMQISFIKDLATLRDPRSSFTFLNYLHQKGRLIHFTNLSTFLPARLEFEDYMRWCAQQFSDVVAYGEEVVEVIPGKSDPSSSVVDFFTVRSRNVETGEISARRTRKVVIAIGGTAKMPSGLPQDPRIIHSSKYCTTLPALLKDKSKPYNIAVLGSGQSAAEIFHDLQKRYPNSRTTLIMRDSAMRPSDDSPFVNEIFNPERVDKFYSQSAAERQRSLLADKATNYSVVRLELIEEIYNDMYLQRVKNPDETQWQHRILPERKITRVEHHGPQSRMRIHLKSSKPESEGAANDVKETLEVDALMVATGYNRNAHERLLSKVQHLRPTGQDQWKPHRDYRVEMDPSKVSSEAGIWLQGCNERTHGLSDSLLSVLAVRGGEMVQSIFGEQLERAAVQGHQLRAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW72</accession>
    <name>B0XW72_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_023800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023800"/>
    <dbReference type="HOGENOM" id="CLU_2670630_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="75" mass="8629" checksum="3CDA94049B0A6CF4" modified="2008-04-08" version="1">MRADIDAMNEWVDGKMHKWALDRVKGHLHLGQLGHQPYLLTPPRWTFGCTLTTARFDLAYYLASDPVSQGSRERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWC6</accession>
    <name>B0XWC6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_024340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024340"/>
    <dbReference type="HOGENOM" id="CLU_000288_77_1_1"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="PhylomeDB" id="B0XWC6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002068">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003052">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="601" mass="66379" checksum="8775EEC58CF3DA58" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-11-27" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWK5</accession>
    <name>HASG_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-linked oxidoreductase hasG</fullName>
            <ecNumber evidence="7">1.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Hexadehydro-astechrome biosynthesis cluster protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hasG</name>
        <name type="ORF">AFUB_036240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="2064" last="2067">
            <title>A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Yin W.B."/>
                <person name="Baccile J.A."/>
                <person name="Bok J.W."/>
                <person name="Chen Y."/>
                <person name="Keller N.P."/>
                <person name="Schroeder F.C."/>
            </authorList>
            <dbReference type="PubMed" id="23360537"/>
            <dbReference type="DOI" id="10.1021/ja311145n"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2022" name="J. Fungi" volume="8" first="0" last="0">
            <title>Stress responses elicited by glucose withdrawal in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Emri T."/>
                <person name="Antal K."/>
                <person name="Gila B."/>
                <person name="Jonas A.P."/>
                <person name="Pocsi I."/>
            </authorList>
            <dbReference type="PubMed" id="36422047"/>
            <dbReference type="DOI" id="10.3390/jof8111226"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of hexadehydro-astechrome (HAS), a tryptophan-derived iron(III)-complex that acts as a virulence factor in infected mice (PubMed:23360537). Within the pathway, hasG converts the prenyl to a methylbutadienyl side chain (PubMed:23360537). The HAS biosynthesis begins with the synthesis of a tethered Trp-Ala dipeptide by the NRPS hasD. The 7-dimethylallyltryptophan synthase hasE then catalyzes the prenylation of the hasD-tethered tryptophan or the resulting tethered Trp-Ala dipeptide at the C-7 position of the indole moiety. HAS biosynthesis continues via tethered intermediates with the succesive actions of the cytochrome P450 monooxygenase hasH, the O-methyltransferase hasC, and the FAD-linked oxidoreductase hasG. The resulting O-methylated diketopiperazine is then released from hasD. Finally, three O-methylated diketopiperazine molecules assemble in a trimeric complex with Fe(III) to produce hexadehydro-astechrome (PubMed:23360537).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">The expression of the hexadehydro-astechrome cluster is induced by glucose.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Accumulates astechrome instead of hexadehydro-astechrome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWK5"/>
    <dbReference type="SMR" id="B0XWK5"/>
    <dbReference type="EnsemblFungi" id="EDP52458">
        <property type="protein sequence ID" value="EDP52458"/>
        <property type="gene ID" value="AFUB_036240"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036240"/>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="PhylomeDB" id="B0XWK5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.462.20:FF:000004">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000461230" description="FAD-linked oxidoreductase hasG">
        <location>
            <begin position="1"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q5BEJ5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="23360537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="36422047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="23360537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="23360537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="468" mass="50571" checksum="3683FB7A010A3EE6" modified="2008-04-08" version="1">MASNPKSDLLNCLSGSNVIVDGDEAWPDAIKRWTGYLGKIPAAVVQVTSEEDVIAAVSYAVQNQRPFVVRGGGHSNGFSTVDSPGIIIDLSRMRKVTVDVERQVVVAQGGATMGDGVKAASSVGMAVATGTCNEVGLIGATLGGGIGRLLGHVGYAADTVLSMRVVVVDQSGVARAVEASPDVNSDLFWGLRGSGHLFGVVVEATFRAYPWTHDTWHSCLVFPPSDAGLVAEAVEKVHYQGGMQGRLVFCAPNKQPIVLLQMWYMGSHEEAASKFQPLLELPSMTDHPLNFVGRRIPYPNLNDSSDRICGYGGRKNLAAFGLKNLSAGACVAALNVYMDFIVQHPEAAQTHVLTEFYSMDVARQLDQDGQETSIPGEFRREVKYWVMPLAWYDDPALDDACAGLNKAIREAFLTQHDGTRARGVGYVNMPFEDDTTTSVFGEGERLERLRNLKLKWDPLGVVQGIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWM8</accession>
    <name>B0XWM8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein coupled receptor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_046660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046660"/>
    <dbReference type="HOGENOM" id="CLU_024810_3_1_1"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="PhylomeDB" id="B0XWM8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="40"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="384" mass="43601" checksum="A6AC07672D1E39D2" modified="2008-04-08" version="1">MCCRPSSVYVRACLWLPRVSSSAFRKPINRLIFYASWGNLLSNSATLIAESSLHGRTQGALCQFQGFMIQWFLPADSLWALAMASNVYLAIFKHYDTRRLGMLEWKYLLFCYGVPFIPAFVYLFLSSESRGKVYGESVLWCWVSLRWDFLQIAVFYGPVWFIVLLILAIYIRVGVTIRRQRRELRKTAWPVSEYATDITVLGDVDLHRTARSVPLGSLQRLTNRERSPASTAASSHRIISREVRSPQNDDGPQNARPSIANSLSSNISPTSTTLSRYNYDLGQSETSTTPASAAYYKYAVLFFAALIVTWVPSSANRVYALAASNHYIFGLSCASSFALPLQGFWNSLIYITVSWKAIGTWFRQSTGRYRHEVHTRNRISYISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWS9</accession>
    <name>B0XWS9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_047190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047190"/>
    <dbReference type="HOGENOM" id="CLU_177926_2_0_1"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="PhylomeDB" id="B0XWS9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135:SF1">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6750" checksum="01F986560F30AE8A" modified="2008-04-08" version="1">MFITRGIPLVNFAVASSALAFQVFVLYPWHNQLDAEFKSLKEEHIRVLNRMSQRTISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX04</accession>
    <name>B0XX04_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_047270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047270"/>
    <dbReference type="HOGENOM" id="CLU_1970029_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="127" mass="13952" checksum="9C9E83BDCA70EB9C" modified="2008-04-08" version="1">MFSNAKKLVWLSEEVAQHKVRGRHQASDTEGQKIQNTKAQTPLRTKATAVNIALINFLGQHPGPTPGTEEPMVASVLASMITDFGDIYGNNMSIAKKLNVSDCEQNIPDCRLQGGAWKYEHVSFEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX06</accession>
    <name>B0XX06_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_047290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047290"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="B0XX06"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="73"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="512" mass="55702" checksum="E47DB4F6462850A6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXC0</accession>
    <name>B0XXC0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_037530</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037530"/>
    <dbReference type="HOGENOM" id="CLU_009116_0_1_1"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="PhylomeDB" id="B0XXC0"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="153"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP52587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="38504" checksum="7014944F04A185AD" modified="2008-04-08" version="1">MSNIYLGVIGVGGVGTAFLNQLARLPNAPKLILLARSTQTLLAPTPAYSPAIPAGDWKAAAETPSLTKSGALSPEEIASYLSSAPGRSILVDNTSDPALASSYPVFLRKGISIVTPNKKGFSSDLSLWKEIFAAAAEGKALVYHESTVGAGLPVISTLRDLVATGDEVTRIEGVFSGTLSFLFNTFAPVSGASNAKWSEVVAQAKELGYTEPDPRDDLNGMDVARKLTILARIAGLEVQGPDSFPIESLIPAELASLPSTADGISQFMTKLPSFDSQMAAIKEGAEKQGKVVRYVGSVDVAKKEVRVGLQQFDKDSAIAGLKGSDNIISFYTKRYGSNPLIVQGAGAGGEVTAMGVTADLIKVIQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXF5</accession>
    <name>B0XXF5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_048150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048150"/>
    <dbReference type="HOGENOM" id="CLU_1447335_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="187" mass="20472" checksum="49EA36F4D7EEB06A" modified="2008-04-08" version="1">MILCAGFAVMFTTCAFTFAVGVYQALYEEMAQEAHSPFVGQSTARIGLIGTLAVALMSMGGPLVMCWAKLRSPRRLLLPEVGSLDVLLGIGASMVYVSTISVALTWFDQRRGLAMGIFISGSGVGGIHCQASTPYLSSYHSLWIFRQRIHLAFPCVSDRTVRRAVLDQRERGPCTSFGGWERRSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXL6</accession>
    <name>B0XXL6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyisourate hydrolase</fullName>
            <ecNumber evidence="5">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_037840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="5"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037840"/>
    <dbReference type="HOGENOM" id="CLU_115536_0_0_1"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="PhylomeDB" id="B0XXL6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.180:FF:000006">
        <property type="entry name" value="Probable 5-hydroxyisourate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="59"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP52618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="195" mass="21104" checksum="FCC14ADCDE75F581" modified="2008-04-08" version="1">MDVGNLQTQSTDQLVRASDRLALYQKQLQASVLSPQITSSSHSISNAAKATDQMSRDPITCHVLNTLSGTPAANLPVTLTFLGSSNGNNASQSPITFNATTDADGRVKNWTATAATATTVSGVLSSLPTADSKTNWAVRFEVGPWYAAQGIESFWPEVEVKFTVKGRGREGEEDWRHYHVPVLLGPWNYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXM4</accession>
    <name>B0XXM4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 transcription factor (Swi5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_037920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037920"/>
    <dbReference type="HOGENOM" id="CLU_013390_2_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001315">
        <property type="entry name" value="C2H2 transcription factor Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001649">
        <property type="entry name" value="C2H2 transcription factor Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP52626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="772" mass="84825" checksum="96F78E2F94AB5AF3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXP3</accession>
    <name>B0XXP3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_038110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXP3"/>
    <dbReference type="SMR" id="B0XXP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038110"/>
    <dbReference type="HOGENOM" id="CLU_060354_0_2_1"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="PhylomeDB" id="B0XXP3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070775">
        <property type="term" value="C:H3 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP52645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="282" mass="31496" checksum="A9227787DB2F4C9A" modified="2008-04-08" version="1">MSVVSLLGVKIVNNPAPFLAPYQFEITFECLEQLQKDLEWKLTYVGSATSSEYDQELDSLLVGPIPVGVNKFLFEADAPDLKRIPTSEILGVTVILLTCSYDGREFVRVGYYVNNEYDSEELTQDPPAKPIIERIRRNILAEKPRVTRFAIKWDSEEDAPAEYPPDQPEADLEDDGAAYGAEEAELEAALIRELEEAEREAAKGGDHEMEGAEETAGKDDEEEDLSDAESEDIEDESDDEEDDLDEDEGGDRDEDVEMGDDTESKDTNAASGHHQQQDIMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXU6</accession>
    <name>B0XXU6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_038610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038610"/>
    <dbReference type="HOGENOM" id="CLU_1282979_0_0_1"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="215" mass="23847" checksum="4587324ED89E6FB6" modified="2008-04-08" version="1">MQASMSPTFLQKEFITKGLTSCPLAVHIPDAPQPPCACGGTVVFHMNQLKDMMANASHLRVDQMLQGIKLALSVCQGYLQCRNCPKDSTSLLLPISTIDFTLQLFEYWISYGLAAQHSVGVDSARIRYGDFELCSEENWWISRFLLRARLIQCKEVFTVLQEAIDVCLGSPSGHLGQGLYDENRGGSCLDQILRGYEETVEAFLRCLSGNDACPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXV0</accession>
    <name>B0XXV0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_038650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038650"/>
    <dbReference type="HOGENOM" id="CLU_184661_2_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7344" checksum="8098A6B1969CCBE4" modified="2008-04-08" version="1">MGGASREGGKAKPLKAPKKGKKELDEEDLAFKERQRAEAKAKKELLEKAKGKGPLNLGQQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYD3</accession>
    <name>B0XYD3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_040510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040510"/>
    <dbReference type="HOGENOM" id="CLU_136313_0_0_1"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="125" mass="13866" checksum="D6616BAFA6A79178" modified="2008-04-08" version="1">MSFSSPSASNPSLATSAYMVSSVDRYTSGSDDEIASLPSESTTSSDLDTLSDDYSDAEEEWRESIEQLELLLTMVIVPFIGKYLGRRCAYWGWTRFMEWKYPVEVVITNKAAFRGAGVVEALSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYP6</accession>
    <name>B0XYP6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">GPI inositol-deacylase</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_041630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001384_1_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003438">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003492">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000814">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="5">
        <location>
            <begin position="59"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="344"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="6">
        <location>
            <begin position="609"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1567" mass="176432" checksum="253BAD07AD9DE705" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYQ4</accession>
    <name>MOC2B_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="1">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Common component for nitrate reductase and xanthine dehydrogenase protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="1">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cnxH</name>
        <name type="ORF">AFUB_041710</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="1"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYQ4"/>
    <dbReference type="SMR" id="B0XYQ4"/>
    <dbReference type="EnsemblFungi" id="EDP53000">
        <property type="protein sequence ID" value="EDP53000"/>
        <property type="gene ID" value="AFUB_041710"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041710"/>
    <dbReference type="HOGENOM" id="CLU_089568_3_1_1"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="PhylomeDB" id="B0XYQ4"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000003">
        <property type="entry name" value="Molybdopterin converting factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000369350" description="Molybdopterin synthase catalytic subunit">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="188" mass="20615" checksum="BE04E6BE2796A23F" modified="2008-04-08" version="1">MATQPPQDQTSTTPSLPPHLDPTTYPRILTSATHNIHLELTYSTLNPTVALEHTSSPAAGANVLFLGTTRDTFEGRAVSQLSYTSYPPLALKSLMSIATRAVEKFDLKGVYIAHRLGVVPISEASIVVAVSAGHRGMAWKAAEEVLEEVKEKVEIWKREEFVDGGMEWRENRERDAEGRILSSTEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ90</accession>
    <name>B0XZ90_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair protein Rad18, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_043560</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ90"/>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ90"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="17">
        <location>
            <begin position="813"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="432"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="719"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="817"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="883"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP53186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123002" checksum="6C216B8FC5176235" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ92</accession>
    <name>B0XZ92_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial tricarboxylate transporter (Ctp), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_043580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043580"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ92"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="199"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP53188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="296" mass="32345" checksum="AB945F00DF8F4BD8" modified="2008-04-08" version="1">MVTAEKDPKSKPSSLRSIIAGSSAGAVEIAITYPAEFAKTRSQLNRRLPDAKKLPWPPFGKQWYAGCTTLIIGNSLKAGIRFVAFDTFKSLLQDENGNISGPRTVIAGFGAGFTESLLAVTPFESIKTQLIDDRKSPNPRMRGFLHGSKIIFQERGLRGFFQGFVPTTARQAANSATRFSSYTMLKQLAQGYVAPGEKLGTASTFALGGIAGLITVYVTQPLDTVKTRMQSLEASKNYKNSFVCAARIFKDEGLLTFWSGAVPRLARLIMSGGIVFTMYEKTMEALDAIDPERKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZL3</accession>
    <name>B0XZL3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-aminopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044440"/>
    <dbReference type="HOGENOM" id="CLU_024709_0_0_1"/>
    <dbReference type="OrthoDB" id="2107894at2759"/>
    <dbReference type="PhylomeDB" id="B0XZL3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000004">
        <property type="entry name" value="Beta-peptidyl aminopeptidase BapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="391" mass="41599" checksum="4DCA431CBD486953" modified="2008-04-08" version="1">MAAINPIPPSARPRIRELLPNLYLGRHRPGTKNSLTDVPGVLVHTESIKRPSTATSHAVNTGVTTILPRRDWFDSGCYAGYFRFNGSGEMTGSHWLDETGLLNSPIILTNSFSVGACYTGVYEYAVQEYKDPATGLVDWFLLPVVAETCDLFLSDIGAMAVTSEMVVRGIDQASADPVKEGNTGGGTGMMCHGFKGGTGSASRVIDGVAFGAETNYTVAALVQANYGAKRDLRFGGAPVGLLMEQEDGAAATAAANEDDARKAKDGSIIVVIATDAPLHPTQLQRLAKRATVGLSRVGGWGSNSSGDIFIAFSTAERIPRAPDFSWKPTVEQQVSVVQDVTINALFEGAADATEEAIYNALVGAEDMEGPRGKIVKALDHARLKSIMERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZN6</accession>
    <name>B0XZN6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_044680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044680"/>
    <dbReference type="HOGENOM" id="CLU_1348648_0_0_1"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="203" mass="22882" checksum="E75A96E3BB870FB5" modified="2008-04-08" version="1">MVDGLHLFFDERMIRTRLPAPKANFASGRPTETSFLPDMIRVIDLDWPETELSPLKETVIVATICGQVLEHKQRPPSRTRDSTATTYDFCRRHRSLNALLAQRIKMLRLHASFEHLNPVFTLTALATYIAVLTLYNGIQSQPLGTEAQAMQLTKALHSEHQQQSLDAVADVALLVTALGQHFQVKHPRPYDPCCAPCEPTRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZX5</accession>
    <name>B0XZX5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_034710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034710"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="PhylomeDB" id="B0XZX5"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP52307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="285" mass="31104" checksum="BB5B4F162AEC0F20" modified="2008-04-08" version="1">MAENNYNSFKYFIIRFPAEHQYVAHVEINRPDKMNAFFEAMWIELGQVFDRLSQDPSVRAIVLSGAGEKAFTAGLDVTAASQGLLSADGDQAVDPARKAAHLRRHIVSFQDCITAVERCEKPVIVAMHGFSLGLAVDLSTAADVRVCTRDTKFAVKEVDIGLAADIGTLSRLPKVVGSFGWAKEVALTARIFGAEEALRVGFVNRVFESKEAAVQGALEMAALMATKSPVAVQGTKEIMNYSRDRSVQDGLRYTAVWNSAMLQTKDVSAALLSGLKKRTPTFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y015</accession>
    <name>B0Y015_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspergillopepsin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_045280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y015"/>
    <dbReference type="MEROPS" id="G01.004"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045280"/>
    <dbReference type="HOGENOM" id="CLU_066466_0_1_1"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="PhylomeDB" id="B0Y015"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.700:FF:000001">
        <property type="entry name" value="Putative aspergillopepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760596" evidence="4">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="114"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="269" mass="28014" checksum="0E68CD61C5266D8E" modified="2008-04-08" version="1">MKFTSVLASGLLATAAIAAPLTEQRQARHARRLARTANRSSHPPYKPGTSEVIKLSNTTQVEYSSNWAGAVLIGTGYTAVTGEFVVPTPSVPSGGSSSKQYCASAWVGIDGDTCSSAILQTGVDFCIQGSSVSFDAWYEWYPDYAYDFSGISISAGDTIRVTVDATSKTAGTATVENVTKGKTVTHTFTGGVDGNLCEYNAEWIVEDFESNGSLVPFANFGTVTFTGAQATDGGSTVGPSGATLIDIQQSGKVLTSVSTSSSSVTVKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y030</accession>
    <name>B0Y030_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_045430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y030"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045430"/>
    <dbReference type="HOGENOM" id="CLU_3049906_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="54" mass="6367" checksum="25572A7D74F0377A" modified="2008-04-08" version="1">MAPKPKLSFDRELDSLLPDYNDLIREQSYPKSMIYYLRESLTKNTLSSALTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1E9</accession>
    <name>B0Y1E9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Decapping enzyme Dcp2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_060090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1E9"/>
    <dbReference type="SMR" id="B0Y1E9"/>
    <dbReference type="HOGENOM" id="CLU_008108_4_0_1"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1E9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="121"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="865" mass="94917" checksum="E266872C4C48FAE9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1F7</accession>
    <name>B0Y1F7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_060170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060170"/>
    <dbReference type="HOGENOM" id="CLU_074873_0_0_1"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="258"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="328" mass="36065" checksum="6A6C70498879B2FC" modified="2008-04-08" version="1">MLNPYPILHEGHHPQVYSLANIPGSILTKMEGPRNRKQRRAAAATATSAASTPDSSFDPSSIPLAHPQKPSPDNVPRGRTLVELIAERQNDILSKEQRNTAKLGPETQFMSVDPLSGKISQFDPSMLSKEQRDEGDRAGPATEDSQIEPDTADNGDDAPIPPLIDTLLLSVPLTTLHLTLAYLAAHQYAETIELEKLLRESAFIAFPILTLLVHLAHGHIVSMHRGSTKEEKVSLFPWSQDKLTLSFVRKLLFPPSMRTMAFLPVAVLLGTKLMTMTNEDPYYAVMKRAPAIGTLWVWSILEIPVGAAALGALGPLIWGVWWKGYGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1L3</accession>
    <name>B0Y1L3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_049700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1L3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049700"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1L3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="328" mass="36268" checksum="7F29DA1674E0F6D1" modified="2008-04-08" version="1">MVSNTTDPSDYCTLDTCPLSLANFNYVPNLAGNLLYLALFGTMLVANLGLGIYYRTWGYLVGMIGGLALEVIGYVGRIQLHYNPFPFSPFLQYLICLTLGPAFLSAAIYICLGHIVVVYGEGISRLKPRTYTIIFVLCDFLSLVLQAAGGAITSIADNDQQDLRQTGINIMIAGLASQVASLAVFLFLCADFAWRVYKNPNKLNESMDHVRKTLKWKAFLIGRFLFPGISPRYIYLTAKGLTVATLAIFVRSVFRVAELQEGFDGPLANDEVTFMILEGAMMAMATLCLTVLHPGYCFGGYWDQTSWRSIKQSSQLSLMELKAQNSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1N7</accession>
    <name>B0Y1N7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_049950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1N7"/>
    <dbReference type="HOGENOM" id="CLU_480558_0_0_1"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="567" mass="65179" checksum="FEC0A132766D125E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1S2</accession>
    <name>B0Y1S2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_060650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1S2"/>
    <dbReference type="HOGENOM" id="CLU_021418_0_0_1"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="664" mass="73923" checksum="22F732135518FCFD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1U9</accession>
    <name>B0Y1U9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="14">2.4.1.132</ecNumber>
            <ecNumber evidence="14">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_060920</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13 14">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="14"/>
    <dbReference type="EC" id="2.4.1.257" evidence="14"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1U9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060920"/>
    <dbReference type="HOGENOM" id="CLU_030619_0_0_1"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1U9"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000240">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000444">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="16">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="230"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP52058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="470" mass="52383" checksum="5A08F2231FBBFD19" modified="2008-04-08" version="1">MARLKPSKVIIIHPDLGIGGAERLIIDVALALQSRGHRVTIYTSHRDKSHCFEEARDGTLDVRVRGNSLFPAHVGGRLHVLMAVLRQLHLTVSVLREIATSEEKDNIFIVDQVPACVPLLKTLGPRAARSSRSRQRILFYCHFPDQLLARRNEGGELLRLAKTLYRYPFDWFEGWAMSASDKVVANSRFTRGVVSEVFGKEKLGDVRIVYPCVDTKAGAPVGTEEGPLWGGKKIFLSVNRFERKKDLALAIRAYHGLGQEKRRGTRLVVAGGYDNRVQENVQYHRELDQLATSLGLQTATSKTVISALSIPDSIDVLFLLSVPTAFRDTLLSQAKLLLYTPINEHFGIVPVEAMRAGIPVLASNTGGPLETIVEGETGWLRDATVVADWTAVMDRVLYEMDQKDLDRMSAVSKARVEKEFSLTAMGDRLEEEITDMLSKERRPFSGFHQLILVFALLGIMSSILAVWALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y323</accession>
    <name>B0Y323_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NTF2 and RRM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_052680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y323"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052680"/>
    <dbReference type="HOGENOM" id="CLU_022209_2_0_1"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001220">
        <property type="entry name" value="NTF2 and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="404"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="537" mass="56964" checksum="5E81185B88C0E8C3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3B4</accession>
    <name>B0Y3B4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_053590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3B4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053590"/>
    <dbReference type="HOGENOM" id="CLU_022957_2_0_1"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3B4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760676" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="547" mass="61537" checksum="2F729C42DAB0FA83" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3G5</accession>
    <name>B0Y3G5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_054120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054120"/>
    <dbReference type="HOGENOM" id="CLU_021051_2_0_1"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3G5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="353"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="536" mass="61125" checksum="01056E8A3940B42F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3G6</accession>
    <name>B0Y3G6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_054130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054130"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3G6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="75"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="612" mass="67295" checksum="5C5CED197D43BF10" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3N5</accession>
    <name>B0Y3N5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="11">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TAH18</name>
        <name evidence="14" type="ORF">AFUB_054840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="11">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="11"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3N5"/>
    <dbReference type="SMR" id="B0Y3N5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054840"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3N5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000015">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="12">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="235"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="75"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="419"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="458"/>
            <end position="461"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="568"/>
            <end position="569"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="574"/>
            <end position="578"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="654" mass="73610" checksum="BEF210430836CD53" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3P3</accession>
    <name>B0Y3P3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_054920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3P3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054920"/>
    <dbReference type="HOGENOM" id="CLU_027974_3_0_1"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3P3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000056">
        <property type="entry name" value="CCR4-NOT core complex subunit Caf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="460"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP51484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="500" mass="53785" checksum="E47E222D99346BCA" modified="2008-04-08" version="1">MPPPVGRYGPSGLSGPYSHLQQAHLQQQQQQQQQQQQAQHHPAHAQSANTALPPPSLGGHPGFAAGNPNTNINPFTLSGTGIANGMSVAGFTGAGDGGGSGLASHAAQIGFARGAQMQQQQLLQTHDGRLALETKAGGVKTRIRDVWKHNLAQEMAVLRQLVEKYPYISMDTEFPGIVARPIGSFTNKADYHYQTLRCNVDLLKMIQLGITLFSADGEVPPPNATDANGQPLGNSLVPAPCTWQFNFRFSLENDMYAQESTAMLAKAGIDFNMHEKNGIDPFEFGALLISSGLVLLDDVHWVSFHSGYDFGYLMKIMLCKPLPENEEDFHTLLKIFFPSLYDIKYLMKHAGRNQAVNDSPLTPAAAQILTNLGQKSGLQDIADELGVKRVGIAHQAGSDSLVTGEIYWKMRQLIFNGKIDEGKYSGQIWGLNGQMPAMTYHMQPHQTPNLNGATIYSAAGTPSTPNTGRQTPQHHGGNIGGALTPGGPGGVMGAFQTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3U2</accession>
    <name>B0Y3U2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_055430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3U2"/>
    <dbReference type="HOGENOM" id="CLU_1280466_0_0_1"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="6">
        <location>
            <begin position="27"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="235" mass="24989" checksum="88E1EF281C0D5125" modified="2008-04-08" version="1">MKNGIATPAPGVLPLEPQVTPAFGVGGSILIATGAILALIGIRNLWYLFLSAAFLTSLGVTVLIVYVMNPPVRVAVQGAYLVAIFFTGMTFGAFSIVFKELTEGLGCLLGGFCVSMWLLCLRPGGLLTDTNAKGGFIGAISAAFYALSFSRHTRPYGLIVSAAVSGGSAVALGIDCYSLAGLKEFWLYIWDVFPLGTLTYPITRNIRVELAVTRQATQGGSSQERGREKERRGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y477</accession>
    <name>B0Y477_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_056790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y477"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056790"/>
    <dbReference type="HOGENOM" id="CLU_005966_1_0_1"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="PhylomeDB" id="B0Y477"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000010">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000019">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000030">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000033">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="97"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="264"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="416"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="582"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="797"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="711"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="980" mass="108637" checksum="B2C7E9CCBEC0E6D5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4C5</accession>
    <name>B0Y4C5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin containing polyamine oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_057270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4C5"/>
    <dbReference type="HOGENOM" id="CLU_004498_6_0_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4C5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="543" mass="61569" checksum="8B976F6F93A7F534" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4P5</accession>
    <name>CREB_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable ubiquitin carboxyl-terminal hydrolase creB</fullName>
            <ecNumber>3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carbon catabolite repression protein B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Deubiquitinating enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Ubiquitin thioesterase creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Ubiquitin-hydrolyzing enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Ubiquitin-specific-processing protease creB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">creB</name>
        <name type="ORF">AFUB_069810</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4P5"/>
    <dbReference type="SMR" id="B0Y4P5"/>
    <dbReference type="EnsemblFungi" id="EDP50644">
        <property type="protein sequence ID" value="EDP50644"/>
        <property type="gene ID" value="AFUB_069810"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_0_2_1"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4P5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0788">Thiol protease</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000395678" description="Probable ubiquitin carboxyl-terminal hydrolase creB">
        <location>
            <begin position="1"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="USP">
        <location>
            <begin position="49"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="574"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3 4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="767" mass="86762" checksum="EFF2CE02A19E94D6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y537</accession>
    <name>CUTI2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable cutinase 2</fullName>
            <ecNumber evidence="5 6">3.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cutin hydrolase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_071270</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (By similarity). Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="5 6"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y537"/>
    <dbReference type="SMR" id="B0Y537"/>
    <dbReference type="ESTHER" id="aspfu-q4wqv2">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP50786">
        <property type="protein sequence ID" value="EDP50786"/>
        <property type="gene ID" value="AFUB_071270"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071270"/>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="PhylomeDB" id="B0Y537"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395252" description="Probable cutinase 2">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P11373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P52956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="214" mass="22326" checksum="C0B300C69C56CB63" modified="2008-04-08" version="1" precursor="true">MNLRLLTLALAGLAAASPVAIEERQLSSGNELRNGACKPITFIFARASTEPGLMGLSTGPAVCNSLKAAKPGQVACQGVGPAYTADLASNALPENTSQAAINEAMELFKQAASKCPDTQIVAGGYSQGTAVMDGSIKRLPEEVKERIKGVVLFGYTRNAQERGQIANFPKDKVKIYCAMGDLVCDGTLIVTAAHFTYGANTGDAARFLLGKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6D0</accession>
    <name>B0Y6D0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_066500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6D0"/>
    <dbReference type="HOGENOM" id="CLU_1053662_0_0_1"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="234" mass="23862" checksum="58A3EC01AED9902A" modified="2008-04-08" version="1">MDNLLCRDKNNHPNGSLTVFPDGHSYNYTGLYYTPSCQDKSYKGCSVACTTYDSYRGQYIWACNDALTEYCCHNDEAGLGQADCCDGGTFELPAPGSGSSSASASASTSTPVSSTSTTTTSSSTLASAPSESGTPSTTAAATAAATASLSTGAKAGIGIGAAGAGIIIIVLVALLLRARRLAAVNRGPSQTEKNTFWASGARTRATQAELEACADAPPSELSAKPAPNRFELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6G6</accession>
    <name>B0Y6G6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_066890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066890"/>
    <dbReference type="HOGENOM" id="CLU_2372378_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="95" mass="10960" checksum="81C35F3FF978BFDA" modified="2008-04-08" version="1">MRIPTEPIQQIQAVITLIVPRYHRYETSGVQSGIRDQGLKWQPLFCPHTRWRAAVPYDRGPHVVVVVVVETPTYNAIIHANQHTQRDSTLLIHNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-05-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Q5</accession>
    <name>DSCC_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DSC E3 ubiquitin ligase complex subunit C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Defective for SREBP cleavage protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dscC</name>
        <name type="ORF">AFUB_067780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="1557" last="1567">
            <title>Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Willger S.D."/>
                <person name="Cornish E.J."/>
                <person name="Chung D."/>
                <person name="Fleming B.A."/>
                <person name="Lehmann M.M."/>
                <person name="Puttikamonkul S."/>
                <person name="Cramer R.A."/>
            </authorList>
            <dbReference type="PubMed" id="23104569"/>
            <dbReference type="DOI" id="10.1128/ec.00252-12"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions (PubMed:23104569). Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA) (PubMed:23104569).</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Impairs growth on solid media under hypoxia and leads to triazole susceptibility (PubMed:23104569). Impairs virulence in a murine model of invasive pulmonary aspergillosis (IPA) (PubMed:23104569).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dsc3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6Q5"/>
    <dbReference type="EnsemblFungi" id="EDP50440">
        <property type="protein sequence ID" value="EDP50440"/>
        <property type="gene ID" value="AFUB_067780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067780"/>
    <dbReference type="HOGENOM" id="CLU_035821_0_0_1"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6Q5"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000406">
        <property type="entry name" value="Putative conserved membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000460155" description="DSC E3 ubiquitin ligase complex subunit C">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23104569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="23104569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="23104569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="309" mass="33135" checksum="EA82B5810E7A8ACC" modified="2008-04-08" version="1">MTFPAFLSPDPTWDGDSTGGPLLLTVRFSASIPDFPLDIENPDITTAAGLKQLIRTHLPPNLSSHRLRLIYAGRGLEDATPLSVSLKLPPSPSRTPVVQEDATTVKGKGKAPIREQPRLYIHCSIGDIVLSDADLAAEAAIATTLQQEQADEGYTGRKKQQQPPPSTTSAPRGFDRLLSAGFTPSEVSALRSQFMAIQSVSRTPDTMPTGAELRELEDRWMDEGSSAMAAGVPGGGEGISFADDDGGFGAGSRGAMDDMLWGAVMGFFWPVGCAMWLRREEGVWSWRKGLAVFVGVVINVAFGAMRIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Z2</accession>
    <name>B0Y6Z2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_068640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6Z2"/>
    <dbReference type="SMR" id="B0Y6Z2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068640"/>
    <dbReference type="HOGENOM" id="CLU_081646_0_1_1"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6Z2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="74"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="178" mass="19744" checksum="5E26613E3A1D4F0C" modified="2008-04-08" version="1">MSYYDVDSILTDSQKLPCTFELEVPGLGILEGNPGEDIKAGTRIDLPLWLGVMLSIGARLGTSRLVTLDLPSALSDRVVNALKADPRTVDLRSLAPHFYSLSERVLDLFEEEEMVDVLINTFKKRAAEIADHAHNPKGALGEGADFLRGLDETERQLFRVAHDSARETRIWAGEAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y744</accession>
    <name>B0Y744_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Phosphomannomutase</fullName>
            <ecNumber evidence="5 12">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_072510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 12"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y744"/>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="PhylomeDB" id="B0Y744"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP49225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="245" mass="27889" checksum="CDD81D9DD13F329C" modified="2008-04-08" version="1">MVTEAASIYPALQDRPIKNTICLFDVDETLTPARRVGGSNLAKQQEQLGTGATDVTSLFDFCFPENGLMAFRLGKPLASTSFIEWIGEEKYQKLVNFILRYFADLQLPKKRGTFIEFRNGMINVSPIGRNASVEERNEYDKEHHIRTDMVNALKKEFPDYGLTYSIGGQISFDVFPTGWDKTYCLRHVEAEKEISGVEYTTIHFFGDKCFPGGNDYEIYSDPRTIGHSVHGPEDTMKQLKELFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7H2</accession>
    <name>B0Y7H2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_073800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7H2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073800"/>
    <dbReference type="HOGENOM" id="CLU_031040_8_1_1"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7H2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="72"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="204" mass="22702" checksum="A75412DDBE265034" modified="2008-04-08" version="1">MRFQHFTRFLRILTTAPSITSLSPRSITRIPFPVSRATALKAAPTIPFLSSFFSSSAKAEESNMSYPEQRSEAEWRAVLSPEQFRVLREKGTEPPYTGEYDSHFSSKGVYTCAGCNAPLYKATHKFKSGCGWPAYFDSIPGAVTRHTDRSFGMERTEIVCSNCGGHLGHVFKGEGYPTPIDERHCVNSISLKFTEDEEAAKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7K7</accession>
    <name>B0Y7K7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase V, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_074150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7K7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074150"/>
    <dbReference type="HOGENOM" id="CLU_005212_1_0_1"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7K7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="700"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="981" mass="109072" checksum="B0DA56F317ABAA80" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7M2</accession>
    <name>B0Y7M2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_074300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074300"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7M2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="69"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="516" mass="56936" checksum="A684F43853C4A66F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7S9</accession>
    <name>B0Y7S9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_074870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7S9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074870"/>
    <dbReference type="HOGENOM" id="CLU_009422_1_0_1"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7S9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="426" mass="46700" checksum="23456324CA0E09D3" modified="2008-04-08" version="1">MGKSSKDKRDAYYRLAKEQNWRARSAFKLIQIDEQFDLFEHENPDKVTRVVDLCAAPGSWSQVLSRVLIKGESFGRRAWIEKKRKESEALKRIDHGSESESPAEEERKDDIAQLKPRRNVKIVSIDLQPMAPLEGITTLQADITHPSTIPLLLRALDPEAYDSASSPTPSAIQQPHPVDLVISDGAPDVTGLHDLDIYVQSQLLYSALNLAVGVLRPGGKFVAKIFRGRDVDLIYAQLRTVFEKVSVAKPRSSRASSLEAFVVCEGFIPPAIHDGSVGMDALKNPLFGGATIPPPVSPDGNIGIEVPDEDTASPREPLTVSEAATVSASDINQQTQIRMLHSQSSIPSLANKPQRFAVENRWIPPFIACGDLSSWDSDASYSLPPDYVNLDPVQPPTAPPYRRALELRKEKGGAYGKTKLGAVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7Y6</accession>
    <name>B0Y7Y6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_075470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075470"/>
    <dbReference type="HOGENOM" id="CLU_660513_0_0_1"/>
    <dbReference type="OrthoDB" id="10677109at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="493" mass="54040" checksum="E3BE2CD5F251993C" modified="2008-04-08" version="1">MGTTPHAKNPSVIDCYDGITPTSVPEQWNYQILYYDPTQPSSPPGSYLSTKDSPDCSVVLVDNSTATDEWRGKFSFRMSRQPPYAFLRGHAVQASQEGIVTEQSGSSGRALACYSEDYLLSLPLNASFVVGVYPREDGASLPDGKVEIVFQSLAQGRYFMTKSVALAPFVALTRRVWQLRRRDWLGDASKTCIVDDLHSPVSGYAMAKMNGTIGYYFLTPTGIMPFANGRLGPDHSTWQDEVAMAGNANGLFSLTKAGDVYLYSRSLSEREPCNISPDHKFSDVTCTITDSFVYAIKTDRTVWRYDPTQQPGTWEPVCQTSDFKAAVLVASDAAVFAIAHPTCPPRYGPSGAVFSLLEGPSPVLIGSDQLHINQLKIASNFLVGLASGDNKMYVWNGDPGSWTDLSTAPLRPWGGVRDVVDGGSLGIVALSGDQREIVQLDRHERRWNSLGVLTDEWRLDEGTLTLCELVDDGPIFGIWNGRAIFIYLPGIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8D6</accession>
    <name>B0Y8D6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_076970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8D6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076970"/>
    <dbReference type="HOGENOM" id="CLU_057540_1_0_1"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8D6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27077" checksum="503195FFDE3E0E3C" modified="2008-04-08" version="1">MGAGGVVIRFFNLAIRVLQFLDAAVILGIFSYFLAVQSQHNQPIPTWMKAVEGLSGAATLYGLLGSLFTCCVGGLAFFAFLAIVLDVCFIGAMIAIAVMTRDGTQSCSGNVNTPLGSGADNIDSASGVRLGYACMLEKATFAVSIIGIFLFLISILFQLLYARHHKREKRFGPSPANGYTYGTGTQRRGFWRRNKRTPETASADDMLPGHPTPHDVEMGDSAEKPGAFGGRFFSRNNNAVANGYGGSAYTGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8E9</accession>
    <name>B0Y8E9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_077100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077100"/>
    <dbReference type="HOGENOM" id="CLU_2157794_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="111" mass="11696" checksum="164BA80139412917" modified="2008-04-08" version="1">MVKLFQSKCGVDHGAMVCNSVGSNQSSILLLLSSPQPCADGPSGSTEDEDIQTLLSHLITSRQGLFCVKMVANGIISLTARILLEGDRPAFELLCNSCSSAAVTDVRHMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y942</accession>
    <name>B0Y942_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_079570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y942"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079570"/>
    <dbReference type="HOGENOM" id="CLU_016508_2_0_1"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="PhylomeDB" id="B0Y942"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760527" evidence="6">
        <location>
            <begin position="21"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="308"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="531" mass="59229" checksum="3E299BD41680D1E8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y961</accession>
    <name>B0Y961_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_079760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y961"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079760"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="PhylomeDB" id="B0Y961"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="46"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP49942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="440" mass="47610" checksum="B699C1AF3526B29C" modified="2008-04-08" version="1">MSGSTMSPSISTQQDEEKAIQPPVVSDSPALESALPPEGGLRGWLCCAGGSLGLFATLGFLNAIGIFQTTYQETLLKDYSSSDISWIFTIQLALIWAPGSLFGRIVDTYGPRPVMLPCIFLCLFSLCMTSLATEYYQIILAQGIGYGLGAGGIFTTCLVCVSQWFVKQRGLALGITVAGSSIGGVIFPFFLRLVMEDVGFNGMIRYTALFLGIILVGAFFLLSARLPPKKWDSEMAWIDFRVFQNRGFAFYCLGSYLVMWGLWAPFDYLPSMAQLSGMSDSLALYLLAIVNAASLFGRVIPGHIGDKVGYFNIIVASAFLSCIAILCLWLPFDYHSSNAGLIVFAVAYGFFSGAFVSIMMPCCAKSGSLETLGRQIGTYQGVIAISTLTGLPIMGAILQRQHNATFMGLQVFAIVTMFLGSVFLLVSRNVLAAAHGTWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9A0</accession>
    <name>B0Y9A0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9A0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080280"/>
    <dbReference type="HOGENOM" id="CLU_1315124_0_0_1"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="209" mass="21707" checksum="AA6C99ADAC802885" modified="2008-04-08" version="1">MRISACISIPYALSISSLIFMIFVAIGCTSTSAPSNQLYFMKARGLEATLDSSFMSKLDGYLESLVARRSLVDNVTSGLSTAVDSVGSVGNTASAAQTLTDVAGSAASTVASVGEDITSATNKTLVNAVDAALSRTRADYPDFLIVGLWSYCNGSFDGSHTPIVTNCSTPSTTFSFNFSGALGLDSSWLSRRSSFCSRDSPLLGLGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9L8</accession>
    <name>B0Y9L8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN dependent dehydrogenase, putative</fullName>
            <ecNumber evidence="4">1.13.12.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_081510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.13.12.-" evidence="4"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081510"/>
    <dbReference type="HOGENOM" id="CLU_020639_2_0_1"/>
    <dbReference type="PhylomeDB" id="B0Y9L8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="388" mass="42556" checksum="6BC3327F181BEBCA" modified="2008-04-08" version="1">MANVPHTYGNEVYANGLQNIKPAISFNPPDWETQARDLLSADSYNYIWGSAGLRKTDTDNRDAFRKWALIPSRLVCADFPSLKTTVLGHEYDYPIAVAPIGVQRIFHRDGEVAAAQAASAQRVPYILSTASSTSIEDVAAASGDGARWYQLYWPPREHDEITVSLLQRAKCAGYRVLVVTLDTYILGWRPSDLNNGYNPFLRADKIGVELGFSDPVFRRRFRERHGVEVEEDMVVAAAEWAQMIFPGRSHALEEIGFLQAHWDGPIVLKGIQSVADARRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXWRCCLIRGVRGGGGCGCRQSAGARGEDGADRAAVCVWTGYCGRGGCLACPAKYPCGSGSHSAPWGDQVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9V0</accession>
    <name>B0Y9V0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_082350</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9V0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082350"/>
    <dbReference type="HOGENOM" id="CLU_034386_1_2_1"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9V0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="319"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="390"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP48793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="444" mass="46651" checksum="E71EDE936428711F" modified="2008-04-08" version="1">MASVSPPKPWERAGTAGGGTVLSASPAGSSTMTPTAVAAAPPTATSSVSATTSTTSSSTAPSLPSRPDTLNAVVNRTASNYSPYGASRFGTTPYGTGYGGYGAYSSPYPRFGTMGSMYGGYGGYGGMYGGMGGMYGGGMPGDPNDPNSLTNSFSQSTQATFQMIESIVGAFGGFAQMLESTYMATHSSFFAMVSVAEQFGNLRNTLGSALGIFTIIRWFRTLIAKITGRPPPADAASLTPSAFAAFMHGRSAPATLPDGSPAPPKPSKKPFFMFLIAVFGLPYLMGKLIKALARSQEEQRKQMMLGPNGEPMQAPLDPSKLDFCRVLYDYTPESQESAGIDLAVKKGDIVAVLSKTDPMGNASEWWRCRARDGRVGYLPGPYLETIQRRPAQQAITSGSEAGSRTNTMASVIEKGQVGDEKKPVLKGKMGDISPESFQKSAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA31</accession>
    <name>B0YA31_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase 178 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_083220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083220"/>
    <dbReference type="HOGENOM" id="CLU_095735_1_0_1"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="PhylomeDB" id="B0YA31"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="204" mass="23029" checksum="98336F9D81D1F606" modified="2008-04-08" version="1">MSGEPPSGGFQPQIIWRQHHHHKLVLPIVFPQNMSFARQSVASARQLLRNQQPRRFASHAAHAEPVNESFGRSFYVTIGAFASAYVLYRLSKSAEESGSQSWISNLIQKWTPSEKLFEERNAIHTALMEKAAQDRHLLQSQGPRATFELKQPEVNFNTSPPYNVPAGSSVDLSAVVAHYEQQNKQMEEARVARMKDGKVVSLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA50</accession>
    <name>B0YA50_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetoplast-associated protein KAP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_083420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083420"/>
    <dbReference type="HOGENOM" id="CLU_010168_1_0_1"/>
    <dbReference type="OrthoDB" id="5367584at2759"/>
    <dbReference type="PhylomeDB" id="B0YA50"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024312">
        <property type="entry name" value="TACC_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12709">
        <property type="entry name" value="Fungal_TACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="85588" checksum="A8482DAC1D27BA12" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA76</accession>
    <name>B0YA76_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_083680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083680"/>
    <dbReference type="HOGENOM" id="CLU_031409_1_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B0YA76"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP48919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="436" mass="47894" checksum="25F48C3AD2CE70CB" modified="2008-04-08" version="1">MSSTSPVPPSGSTNGDRAADSSSSPTSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNQRNRQLRNEETGEPIDLVTLPRTHRRRREKKLMTMDEVNSRFPLTKYKAWRSTRANASIPTAEVISTADSSLHSPNIKNGTLVVDTSVSPSLVKSASTDSQRQMGPTIAQTSTVAPDAGAQFAQLDEKSNGRPIFADCIHARDVSKYTNDEMKDIHNQDSCECHGLEDIGDADHPIRTAPLAELLPTPADSCAICLDVIEDDDDIRGLTCGHAFHASCVDPWLTSRRACCPLCKADYFTPKPRSDPVVERASTDRRSMVGTYAPSRPRPVFIGWRSNPFRRTTILPQRLMRRDGIPPSQLSGALNVDSYMAHNASDTRSEISRPQPRGSMRLFPRLRNSLRLPSSSLHRAPRNAGSAMGASQPSDSRSTADVEAGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAA0</accession>
    <name>B0YAA0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_083920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083920"/>
    <dbReference type="HOGENOM" id="CLU_108087_0_0_1"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="223" mass="24864" checksum="E48F8CEB3EFF1D9E" modified="2008-04-08" version="1">MEWLEKYLIIRGGRCKPTNIEAPKYEWPDSPVEPVGPCREAFNVQRNLFVDLEKLCTLAEKCRDTAIVNAIESRFLRKHAKHLKNLGDLLQQVTRVSKQPGLGLYHLDAELRHNNGCIPWMSMNDPDTIEEGIRAVTKKIGGGLALQTHHEGTKLASKESTFAGVGLRLKKRDKSGPKVEVNQTPCSPCFGCWDSICITMSQKLEQTANSKGLCVATKGFSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAC5</accession>
    <name>B0YAC5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UbiA prenyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_084190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAC5"/>
    <dbReference type="SMR" id="B0YAC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084190"/>
    <dbReference type="HOGENOM" id="CLU_075330_0_0_1"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="PhylomeDB" id="B0YAC5"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="343" mass="38178" checksum="3555EAD32B8627C3" modified="2008-04-08" version="1">MCKMYKVVETDASPGQRSVLQLVKDLLILSRFHKYNPWLAVFSGGVSLPILIGNSHPLTSGVSVWATLLAGANQIATHPASISADHIVKQTLLCLICGYIFCGAGMVWNDWIDRNIDKNVARTKNRPLAAGRVTATEGFIWMMVHVAAMIPVTISTILYPFGKRQLCRRLYIYPQYFLGFSLAWPGAIGWMAIKGRQIPFTQSISESLPLSITVFTWTLYLNTAYSYQDVVDDSKMNVNSAYVAAGSRIHMFLVILAGLVLGSLYLQLRAQNSGWLWASWMCVWALSFVHQLLRFDAKKPESGGPLHKENFALGVWTIVACAAELGLSSGMADQFFSNRVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAE3</accession>
    <name>B0YAE3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-leucine-rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_084370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084370"/>
    <dbReference type="HOGENOM" id="CLU_1272021_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353:SF32">
        <property type="entry name" value="AAC-RICH MRNA CLONE AAC4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="243" mass="26051" checksum="FFCE1DCDF31EAB6C" modified="2008-04-08" version="1">MFLRICVSYRLIKKKSSYINSNNNRHNNNNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNNNGMNCETSHHQQRGVLPNGSTACQPPPCPAPEGQEGHQEEEEDGEDGFIHQDSGKTIIATTYVYRSSRKRRRGRRSGTCAQAHQGQRTPQSHQGGGGGGKGKEEQGGKEEQRGQGGQGPGLCLGYEIQGKHNNDGLSMKHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAG2</accession>
    <name>B0YAG2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_084560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084560"/>
    <dbReference type="HOGENOM" id="CLU_022271_0_0_1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="PhylomeDB" id="B0YAG2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65069" checksum="0F93C50ECC7F73FD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBM8</accession>
    <name>B0YBM8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_087200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087200"/>
    <dbReference type="HOGENOM" id="CLU_096188_0_1_1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="PhylomeDB" id="B0YBM8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF3">
        <property type="entry name" value="CUPIN 2 CONSERVED BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="182" mass="19797" checksum="C8A1CC41D99D1CA6" modified="2008-04-08" version="1">MPSKPKNIRPLQRYITTHDASGKAIFSSALSEEMPVTTMADGADFSLAYTSSHFPAKLNNDDDIPEYANYLSSPPGIVISTGTVCRIVDMQPGATSPMHRTVSLDYGVVLEGEVELVLDSGETRLMKRGDVSVQRGTNHAWRNTSQTEWARMLYVLVPAEAIEIGGKKLGEEVGEIGVRPST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC65</accession>
    <name>XYL2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable D-xylulose reductase A</fullName>
            <ecNumber>1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">xdhA</name>
        <name type="ORF">AFUB_089090</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP48196" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.1.1.9"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48196.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC65"/>
    <dbReference type="SMR" id="B0YC65"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="PhylomeDB" id="B0YC65"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0859">Xylose metabolism</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000393507" description="Probable D-xylulose reductase A">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="358" mass="37866" checksum="AE5E4D9590278E3F" modified="2010-04-20" version="2">MSKSTATAQNLSFVLEGIHQVKFEDRPIPELKDPHDVLVNVKFTGICGSDVHYWEHGSIGQFVVKGPMVLGHESSGVISKVGSAVTGLKVGDRVAMEPGIPCRRCEPCKAGKYNLCEKMAFAATPPYDGTLAKFYVLPEDFCYKLPDNISLQEGALMEPLGVAVHIVKQASVTPGQSVIVFGAGPVGLLCCAVAKAFGAAKIIAVDIQKARLDFAKKYAATSTFEPAKVSAVDNADRLRKENNLGVGADVVIDASGAEPSVHTGIHVLRPGGTYVQGGMGRSEIMFPIMAACTKELAIKGSFRYGSGDYNLAVGLVASGKVNVKDLITGVVEFHDAEQAFKEVKAGKGIKTLIAGIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCL1</accession>
    <name>B0YCL1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxylase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_090580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090580"/>
    <dbReference type="HOGENOM" id="CLU_107214_0_0_1"/>
    <dbReference type="OrthoDB" id="2338662at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06587">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058997">
        <property type="entry name" value="YycE-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058998">
        <property type="entry name" value="YycE-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22659">
        <property type="entry name" value="YycE-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22658">
        <property type="entry name" value="YycE-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760609" evidence="1">
        <location>
            <begin position="28"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="91"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="225" mass="25273" checksum="44A463A8EE439193" modified="2008-04-08" version="1">MTIFSRLISRLMSRLMSLYLYLISALRQPVVDDDLRQKFAVWSYSRLGPHEFIAVTIACVIRPSSHCVKMTHPTPQTPTLATPGTGRHPSATSHIRIARPCRDFTAAERFYVDGLGLKVLWRSGPAHEVEGGHELLMLGWPGAAWHLELVLMHGNDEANAPKPTEEDLLVIYVDGAIEPGVVERLVENGGTRVQHPNEYWEKWGVTIKDPDGYLLVLCQRGWTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCR4</accession>
    <name>B0YCR4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_091120</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCR4"/>
    <dbReference type="ESTHER" id="aspfu-q4wgm4">
        <property type="family name" value="PGAP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091120"/>
    <dbReference type="HOGENOM" id="CLU_006103_1_0_1"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="PhylomeDB" id="B0YCR4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="898"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="965"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1111"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="14">
        <location>
            <begin position="210"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="15">
        <location>
            <begin position="804"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP48395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1156" mass="128817" checksum="408F707E9D801553" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCR7</accession>
    <name>B0YCR7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_092950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCR7"/>
    <dbReference type="HOGENOM" id="CLU_051208_2_1_1"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="PhylomeDB" id="B0YCR7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="7">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="217" mass="25020" checksum="DE2864525872084B" modified="2008-04-08" version="1">MLRSKNSAPSSGSGVKEWSERLDSVGQKARLPRSVQALYLRPLRRKPEFGLPVCDLQLRSYSVRNLEFFADFALRAAYYLELPVSGPVPLPRIVERWTFPRSNFVHKKSQENFERITLRRLIQIKDGHPQAVQAWLAFLRKHAFYGVGMKANVWDHESLDVARNMDESLPDIEKSLEPYLSHFGYRSDGSDQSAVFDLLESERFTHNKSPLTDIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCS1</accession>
    <name>B0YCS1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_092990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092990"/>
    <dbReference type="HOGENOM" id="CLU_009437_2_0_1"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="PhylomeDB" id="B0YCS1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000009">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="51"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="464"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="745" mass="85037" checksum="52E398BF48344177" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDD6</accession>
    <name>B0YDD6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_095190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095190"/>
    <dbReference type="HOGENOM" id="CLU_046550_6_0_1"/>
    <dbReference type="OrthoDB" id="6082470at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31728" checksum="2737EFBE50F3D1F4" modified="2008-04-08" version="1">MALTNIPHINLLCMEERFIDAFQRALAQHWPETNTTPKPTITILNTSLRQVPSSTKFDLIVSPANSYGRLDGAFDDAISRVFCQPPKHEYNTLTEATQKVLYKQWRGFAPPGTCTLVPFPDELIGENEWGCRWVAICPTMRYPDRVTWDREIVYECVWSLLCQVEGWNRGCKKEKRIESILITPLATGVGKVSAAKWAAQFVLAMRHFVDALRRPQRWAALSWGDLTAEVEEVKTTWELKRDGGILGQMWPELDASWYPNSRTINVSFGLTSPQVKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDH1</accession>
    <name>B0YDH1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_095560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095560"/>
    <dbReference type="HOGENOM" id="CLU_014181_0_0_1"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="PhylomeDB" id="B0YDH1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="410" mass="46070" checksum="F058873CA97392F0" modified="2008-04-08" version="1">MEYHFVPPEERAKDDKGNLLPWGYVYKDEARNPRRPPEESGPFGKRRNARYEQARSRTRTGTPAKRENPNVAEFGRLFAQQQEEEKSRNILPKSSSSSSLDNTRKQTEKIATECILYGYRSKDGEWKVIDKYEKISRGLICEDYPRSDPNSTNGFAQLLSGGDVVIRSNLSADANRKSKRYAGGFHWIKVTFDSTIAADRACFYSPQEIDGHLVFCELYHGSGPAEDAPIPVDSSKAVQFKSKAPRTLTTSHSTTFLQPQDKDRAATLPRSFAMNNLSGVAESQEEASQISTSTASSATATGIEQPSALQQRNVSKESKPESEFMTHIPTVRRTKLRPISEALPPQPTVTERVLRSIPILSWFTGDIVGDGPQLREDGSFDYDKSNAYWRFWYMVDMILGTDICGLKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDK2</accession>
    <name>B0YDK2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_095880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095880"/>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="PhylomeDB" id="B0YDK2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="190" mass="21114" checksum="52F445E46415CA80" modified="2008-04-08" version="1">MTNATIAPTTTAAPVTKSVDAPIADENTPLFSPSLISPDVLAVLPADYTIRPLCRSDYKRGYLDVLRVLTTVGDINEEQWNSRYEWIRARSDEYYLLVVCDGEGRIVGTGSLVVERKFIHSLGMVGHIEDIAVEKGQQGKKLGLRIIQALDYVAEKVGCYKTILDCSEANEGFYIKCGFKRAGLEMAHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDQ2</accession>
    <name>B0YDQ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_096380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096380"/>
    <dbReference type="HOGENOM" id="CLU_062081_1_0_1"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48192">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48192:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="39546" checksum="C7DBD8D3C5990BCB" modified="2008-04-08" version="1">MPAVLVQNMTSLPNAQAPIMENPTADKKRNKLGYHRTSVACVHCRRRKIRCLVAADDPQGRCENCIRLRKECQFFPVDQQPPVEKKSRPSSRLESASTDPSTTSSSPPTMGGGADHSESFFAYQPMPLDASQDASGFHATSFPGNPMSSFVPGSTDFAAAPTLDPSVPWDEYTTISDPQILSAMAAGKHQMMNVPPNAWSPGPNNMVAMPPNPAMAATPTVPSQSQPISPVQTYAMQPDGSVWPVAQPTRSMTFPAQPEMASYPNPSQFSQQMHTDLKRRMTSPAQGYPGTPINPQSPPPAELQTTTVSMSYPGQPAGMGYPGWHDMNGMPTMNVVQYPMYTADPAQQAAFGAPPAHMGHPGQGPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDR8</accession>
    <name>B0YDR8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glucanase</fullName>
            <ecNumber evidence="15">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_096550</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="function">
        <text evidence="2">The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="15"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096550"/>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="PhylomeDB" id="B0YDR8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758910" description="Glucanase" evidence="17">
        <location>
            <begin position="21"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="424"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP47802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="48206" checksum="87AE267031905E14" modified="2008-04-08" version="1">MDSKRGVVAAVLALLPLVSAQQPAASSAGNPKLTTYKCTTAGGCVAQDTSVVLDWGYHWIHTVDGYTSCTTSSGVDSTLCPDAATCAKNCVIEPANYTSAGVTTSGDSLTMYQYVQSNGVYTNASPRLYLLGPDKNYVMLKLLGQELTFDVDLSTLPCGENGALYLSEMSATGGRNEYNTGGAEYGSGYCDAQCPVIAWKNGTLNTSGASYCCNEMDILEANSRANSYTPHPCSATDCDKGGCGFNPYALGQKSYWGPGGTVDTSKPFTITTQFITDDGTTTGTLSEIRRQYMQNGKVIANAVSSTGVNSITEDWCTSVDGSAATFGGLTTMGKALGRGMVLIFSIWNDASGFMNWLDSGNAGPCSSTEGNPDLIKAQNPTTHVVFSNIRWGDIGSTFKGSDGSVTTTTSTTSTKTTTSTAPGPTQTHYGQCGGQGWTGPTACASPYTCQVLNPWYSQCL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDS3</accession>
    <name>HRMC_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hypoxia responsive morphology factor C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrmC</name>
        <name type="ORF">AFUB_096600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2019" name="Nat. Microbiol." volume="4" first="2430" last="2441">
            <title>Fungal biofilm morphology impacts hypoxia fitness and disease progression.</title>
            <authorList>
                <person name="Kowalski C.H."/>
                <person name="Kerkaert J.D."/>
                <person name="Liu K.W."/>
                <person name="Bond M.C."/>
                <person name="Hartmann R."/>
                <person name="Nadell C.D."/>
                <person name="Stajich J.E."/>
                <person name="Cramer R.A."/>
            </authorList>
            <dbReference type="PubMed" id="31548684"/>
            <dbReference type="DOI" id="10.1038/s41564-019-0558-7"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probably modulates the generation of the hypoxia-typic morphotype (called H-MORPH) with altered biofilm architecture that leads to increased host inflammation, rapid disease progression, and mortality in a murine model of invasive aspergillosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal bipartite nuclear localization signalis required for nuclear localization and generation of the H-MORPH morphotype.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the hrmA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDS3"/>
    <dbReference type="EnsemblFungi" id="EDP47807">
        <property type="protein sequence ID" value="EDP47807"/>
        <property type="gene ID" value="AFUB_096600"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053540_0_0_1"/>
    <dbReference type="OrthoDB" id="4425826at2759"/>
    <dbReference type="PhylomeDB" id="B0YDS3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000460414" description="Hypoxia responsive morphology factor C">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA recognition motif (RRM)-like domain" evidence="2">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B0Y8Y7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q4WW97"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="31548684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP47807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="342" mass="39583" checksum="21E032AB2CF76CFB" modified="2008-04-08" version="1">MRTKTLQSIQDMVEQLNRRQSMLGDYESTLEERLALVCNPPKRLQRMKIPRRKSEYSSHDRLKRARKIYLEVLENFPLIFVPFILVVPPNACRTWKASEVQRHLKDCEGIHLSYETRANFDGYCRTLRFGLESALTLNLVSCSRPTTITEADDAWAYNAADMDTAVKFFSEAIYKAIESSPKRLREKENQFVKSTQCIQMRFPRHNQQDAIVRLDVGFDSEVVKALFPTAWERLSSVHGFRSSSQSTNRNIEQLEPHLYDNACFTLQGATVSEIPTVLGPHVYRAIKESQLRQWETDNFLLKTTDCVSLDISRRQPYEGTLCLRVGFSLGVFMATQLYSFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE29</accession>
    <name>B0YE29_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_097640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE29"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097640"/>
    <dbReference type="HOGENOM" id="CLU_1668977_0_0_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="PhylomeDB" id="B0YE29"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="158" mass="17102" checksum="08C7D3EACE71AD09" modified="2008-04-08" version="1">MPHDGWRTLLPFIIGTYKRGHAEVKQESLVAWYRTTPGSACGTGGTSANTQSHAQIEFSPLEVVADRIFYSALLTEYATPEVIIGSTTQKGTWRNLPASGRGIYHGSAPFNGAKGDVEVTLWREGNRILTLKGKGISGSCYNGVQNWNAWVGSTQSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEK0</accession>
    <name>B0YEK0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_099450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099450"/>
    <dbReference type="HOGENOM" id="CLU_108553_0_0_1"/>
    <dbReference type="OrthoDB" id="3520229at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="148" mass="14900" checksum="E0D6CA261CB52300" modified="2008-04-08" version="1">MTSMSTSTTTGTAAASTCTGNRWVLPVQDVACALPATGNYSSIMDKCCSPAAVTKYNDGCGLYCLAQGQSMGDLLDCIKENGGNKDVFCGGQLNATATASLSETASSTATRTGTGASASETRDNGAPTKRVSVLGVGLVAMIVCGMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEL0</accession>
    <name>B0YEL0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_099550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099550"/>
    <dbReference type="HOGENOM" id="CLU_1057607_0_0_1"/>
    <dbReference type="OrthoDB" id="4509553at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760648" evidence="2">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="263" mass="27151" checksum="B07756BCAD4AAFD1" modified="2008-04-08" version="1">MLLSLVTVISVFQLAIATNLNPPILYSRHAAQEGSLEKRETCEDGSRCLLGSCCGDGCALNCCALDNGGLGCGITERCQFRGNVFVGCCGNLLGGCTGEATHVTVHTPYSTVTLGAPTDARTTRTSTRTTTTTEQMFTAISVTKSATATATATATATATGSRSTTTRESETATEGETGSSPHSHLVSVLSTSVAAETTSSTSHRSAATTAAFSPNNNGASAMGVEAPVLAGMVALGAVLFRQSSVVSHQSSRFWEMSHMEYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YET1</accession>
    <name>B0YET1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_100270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YET1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100270"/>
    <dbReference type="HOGENOM" id="CLU_2145310_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="112" mass="11496" checksum="0434A832456AB895" modified="2008-04-08" version="1">MSSIPRTSRMVFVNRNTCLFNDRIAINNSLLSCPDDPDPGFSLVASRWQTVEPSSVHFLTHGRQGESVAITDLVESGGTVGAARRRAGPGAGAGTGPGAAERVDRGSAGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEV3</accession>
    <name>B0YEV3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium transporting ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_100490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100490"/>
    <dbReference type="HOGENOM" id="CLU_520709_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0YEV3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="6">
        <location>
            <begin position="356"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="523" mass="58330" checksum="82C1CA613EE81873" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMH3</accession>
    <name>B0XMH3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002730"/>
    <dbReference type="HOGENOM" id="CLU_056022_0_0_1"/>
    <dbReference type="OrthoDB" id="4414363at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50989" checksum="CAFAC8CC7262D3FD" modified="2008-04-08" version="1">MMLSPAPQHRSGLTPQSPFHHDLHNHHHQHHHNPSASTSKPPSMVVPSTQIQEPAQLPTPNQSGPTTMPTDEDGNDGLPQDFSGRGKRLTLEEQKSLFRLCEQYMNRYDAHEYPKSFWMKISELLLKSTGRKYSWQSCRRRMQQYVEKRKTYWAAFDADKTLPDLGDMDEDLASDIDDWMGRCELRLQNEEKERRDKAQKTELEQAELARALKLQRTFEWAKNLPPPEEMERQPTHWGMPPHRFVTMNGRLLQGLDLAFHLSKVRPDESRQLALDAVLLHGQFGYPSAAAHDQKPKPDPSGPCLGIFNPGNRKRPFDAIDGAASERPARQPRMDLDPHTQSQSQPQPPTQAQPASGDKPSEKRETPAAMLARKNVDRIVNHLWLQFAKGIAPYYEEHRDQPQTNKQFGLVLYDLYRDLGRAFTKAVNRLVDLEWDSECESASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XML7</accession>
    <name>B0XML7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_003190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XML7"/>
    <dbReference type="SMR" id="B0XML7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003190"/>
    <dbReference type="HOGENOM" id="CLU_024513_1_1_1"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="PhylomeDB" id="B0XML7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP55622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="254" mass="28892" checksum="1A7A7EEA769F3215" modified="2008-04-08" version="1">MTADVKSAAARILSTDSSRDPSFNNFSFTPFLRKSFGFGLASDVPVCKAYSEGHCPLGPACPDRHPTPSRVTTSTTTASGLAPSTTHGSLVCKHFLKGLCKKGLKCEYLHEYNLRRMPECQSFSRSGYCPNGDDCLYQHVREQARLPPCENYDQGFCELGPLCSKRHVRRRLCKYYLAGFCPEGKACPDAHPRWSENLPKPTMRVEKTEEELERERALIREEQEREKEREREWRSERGRGGGFMRGRYRGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMN8</accession>
    <name>B0XMN8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein Pth11-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_013620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013620"/>
    <dbReference type="HOGENOM" id="CLU_019101_1_2_1"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="PhylomeDB" id="B0XMN8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="535" mass="59460" checksum="C7562C4C6C6571BB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMU3</accession>
    <name>B0XMU3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_014190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_037323_3_0_1"/>
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    <dbReference type="PhylomeDB" id="B0XMU3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="311" mass="33982" checksum="29BEA7BC73D83364" modified="2008-04-08" version="1">MHTLKATASSSLNLGPGNYIYSITPASPGSLAAIASDDSLRVFDAAGLGRVAVVAAKTHGNGGVTALRRYGSGRDQQLLVTGGRDGKVKVWDLRAGKGSAAVEMETDGLVNIYDTTITDEDDALVQVINHGSVHHAGFLGERTIYALSHDEDFSVHPATDPDEQAEEPKPIQFGDLRQPLNCEYIAQLCTGSQSAYIAAGHKLDKRLDLVPLIPDPWRFDQANLWRLPGAHGEEVVRSIYVDEQVCLLYSCFKINPDSPFLQGHSVFTGGEDGFVRAWKPVDEDETQGEYSSAKPSRPKEKKREKERFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMX2</accession>
    <name>B0XMX2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_003620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMX2"/>
    <dbReference type="HOGENOM" id="CLU_1294105_0_0_1"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR RGLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="213" mass="22824" checksum="7F5E21096EA7B7D0" modified="2008-04-08" version="1">MLEVSPPIASQTADSQDQPEDNTVCTRAQGKSSCKLRAGCDGCHAAKTRCTGGTPCARCYRDDLRCHYSYKAKVGKPKGSRNKKTIERLRRMREAKKGIHEAQGAAPTPPATSNPTTAGSSSDARPHLLQIPSESGDISTPTSSFEPAIEELFLSNEYLLGLDNHWPLTAAQSPSRTVCLFQSVCSMLPLMGLEGSGQCSTALECHSSPVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNT7</accession>
    <name>B0XNT7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial F1F0-ATP synthase g subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_015620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015620"/>
    <dbReference type="HOGENOM" id="CLU_083674_0_0_1"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="PhylomeDB" id="B0XNT7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="196" mass="20817" checksum="6AB60033A344BE04" modified="2008-04-08" version="1">MPVTASRAVLRQSQFLTRRTAVRYASNTSEAASKASQTASSAVSKASEGLSRVTSTAGPAISNAAQGLGSALRKVGGRTGKVIAFVDSLIPPTIYYSKVGLELAKLVFRGQNMTPPNLATFQAYFQPLVNAARNPATLKNFSFQNVISRVRNASKKELAFAGVTAAEVIGFFTVGEMIGRMNIVGYRGHADHGDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPG4</accession>
    <name>B0XPG4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_006390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006390"/>
    <dbReference type="HOGENOM" id="CLU_041441_0_0_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="B0XPG4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="370" mass="40415" checksum="FEBACA5979A8C73A" modified="2008-04-08" version="1">MRLQKTRFVCVSDTHGYAPSEAGFKLPAGDVLIHAGDLTNQGSLSELRKTIEWISKADYEVKIIVCGNHDITLDPSFYAKYGSTFHNQRLENSEQCMEVVRAGSPSVVFLQHQSALVRLTRADGPKTIFKVFGSPYSQFTGTWAFGYESADAGALWGQIPLDADIVITHTPPHSHCDSLSTGESVGCIALRQVLSKVRPLLAVCGHVHEARGYERVKWASPSSTNAGPEQTEHQVVRGVLPPRESKKQNLVDLTGKKGERLDNDGYSVQANPNLRTASFTPSQNALLLPSIAASTSIMMPDSPQQSPNAPFSPCSSLIEDTGRGEIHPRRKETCIANAAIVASKWPHQGGKKFHPPIVVDLELPIWSELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPL3</accession>
    <name>B0XPL3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_017070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017070"/>
    <dbReference type="HOGENOM" id="CLU_018354_9_1_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="PhylomeDB" id="B0XPL3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="450" mass="51189" checksum="6D72595755E34CBE" modified="2008-04-08" version="1">MRIIWRASADPAVYEEARVGRVFNHRRPRRYPLAVVKATCLEDIVLAVKLAKEKKCRVAVRSGGHSWAAWSVRDESILIDLGDYKHLEVDAEKRMARTSPSMTGKEINGKLIKEYGLMFPGGHCPDVGLGGFLLQGGMGWVCRGWGWACERVKAVDVVTAEGELLHCNENQNEDLYWAARGAGPGKALNLHHQFLMLILESSSWQASLVWIVAITPDFDRDTEIAVVSMYPEGSNEICLFVLLVTLKHTPEEAEAALTPAQQSRPAGTIEEWFCREDSLENQYVNQGKANPEGHRYCAENAYLHNDADVPKVLEEAFTTLPHRKAFALWYGMNPCSRRDLPNMALSMQSDHYFALYTIWEDEKDDARCQAWVKNVMKQVQRHSVGAYLGDSDFQERQTRYWSESNGRRLMDIRRKWDPTGRICGYLDRGDVSRTRGLDNVHEWETVPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPU6</accession>
    <name>B0XPU6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_007620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007620"/>
    <dbReference type="HOGENOM" id="CLU_034301_0_0_1"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="PhylomeDB" id="B0XPU6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="456" mass="51518" checksum="7781ADFE6EA4DECF" modified="2008-04-08" version="1">MEPMNPEPNQEPPSLSKSLHTALTDLHRRPYPHVPNPPSCKKRASVALVLRVRPAYDHWPDSTSLPAEQGQTISTEQRLETFFSQPWVQHGSPEVLFIKRASRVGDRWTGHVAFPGGKRDLEDTDDRAVAIRETSEEVGLDLTTDDYIYIGNLPERVVTTSWGSVPLMVLCPFVFLSTRSDSPILKLQPAEYVDMSQRFANRGGLIARLLCRSLMGWMEFAAIQLQPSESLNCTTTPNLDTITNQSSPSIFQRWKTCFSTAASVGSTRPLHLWGLSLGILADFLDMLPPHTAVRLWKYPTFTSLDLRFIISLLTYRLRKRNILHVRSGARGDMSNTAVDSQTVALPVLQEVNTQHDYNDVGIGGLGVGRYYGASDNASDRSTYAVGIMLRGYYEKLRVAIYVFLAWRIALGSVAAVYAWKFLRDRRIQQVDYHRFQAHLELNQMASRPWNVLFCTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPX2</accession>
    <name>B0XPX2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_007870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007870"/>
    <dbReference type="HOGENOM" id="CLU_619591_0_0_1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="PhylomeDB" id="B0XPX2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="33"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="57046" checksum="5431568776752596" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQF2</accession>
    <name>B0XQF2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_009740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQF2"/>
    <dbReference type="HOGENOM" id="CLU_015118_0_0_1"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="PhylomeDB" id="B0XQF2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="376"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="549" mass="59608" checksum="0DC99CA74F3DC1A4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQJ3</accession>
    <name>B0XQJ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin subunit 5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_010160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQJ3"/>
    <dbReference type="HOGENOM" id="CLU_091867_0_1_1"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="PhylomeDB" id="B0XQJ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="119" mass="12653" checksum="F3237228482FE662" modified="2008-04-08" version="1">MPPTNTPTSDSSSSGGAPPGAVNITSLSVPQLRALQTRLTSELEHLTTSHQKLRAAQSRFRDCVRSINDGVVGSEKKGTAGKDDILVPLTSSLYVRGKLADREKVLVDVGTGFYVEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQQ5</accession>
    <name>B0XQQ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde reductase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_010790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010790"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="B0XQQ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000426">
        <property type="entry name" value="Aldehyde reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="39421" checksum="0E84223EEC87ABF9" modified="2008-04-08" version="1">MGSLAPTIVPPGGLVLVTGVNGFLASHIALNLLERGYKVRGTVRSQEKADWITEAIAKRYPDASFETALVPNISAPGAFNEAIRGVDGIAHVASDLSFGSDPNKVITPMLEALRHILTSAAKEPSVKRFVLTSSAIAALTPQPEQAIHVDTNTWNDSSIERAWRPAPYEPERCWDVYAALKTSTERELWRFAQENNPAFVVNAVLPDFIVGPIIHARQNGSTGRWVKEFFDDPVHYSKPLQTFIPRHFVDVTDVALLHLAGLTHEDVQSERLLAFAGPFNFNSWLHVFRQIDPAKPWPADDPNQVHDRSTVDTRRSKELLKRYSRLDFTSFFDSVRDNCLNSDPEWKRSNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQR3</accession>
    <name>B0XQR3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_010870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010870"/>
    <dbReference type="HOGENOM" id="CLU_018821_1_0_1"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="PhylomeDB" id="B0XQR3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.510:FF:000004">
        <property type="entry name" value="Putative RNA export mediator Gle1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP56377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="524" mass="60644" checksum="E072A36D41C64AAD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQS4</accession>
    <name>B0XQS4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CORD and CS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_010980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010980"/>
    <dbReference type="HOGENOM" id="CLU_040079_1_1_1"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="PhylomeDB" id="B0XQS4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="132"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="207"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="314" mass="34609" checksum="6F050AF942484728" modified="2008-04-08" version="1">MASKCVHKGCGKEFTDPDEDCLYHPGPPVFHEGQKGWKCCKTRVLTFEEFLTIPPCTTGKHSTVDDTPAEPEKESDASSVLEQQVAAASPAPAPPRPAVSPAIAPPSNAATPAVEDTEEDDPALEIPANATCRRRGCNKGYDPSISRDEEKCVYHPGQPIFHEGSKGWSCCKRRVLEFDEFMKIQGCKEKTRHLFVGKGKPAGEEKVETVRNDFYQTPSTVNVSLYLKKIDKDNAKVTFSSTSVEFDLPTTDNKRYKDTYPLFAPIDPEGSSFKVLGTKLELKLVKADGTSWPVLRSDDKWTGERIQVGQAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRE3</accession>
    <name>B0XRE3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short chain oxidoreductase/dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_002170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002170"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="PhylomeDB" id="B0XRE3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760410" evidence="5">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="284" mass="30483" checksum="A673EA80BDF18135" modified="2008-04-08" version="1">MAAPQTWLITGASSGFGVVLAEAVLKAGHRVVATARNPIKAAQTYPQIESLGGTWLQLDVTRPDTKETVEDAIRKQGRIDVVVNNAGYALLGSVEDMSEEEIHQQINTNVYGPMRVIKAALPFMRAQKSGTIVNISSIAGLQAQPSCSLYAASKFALEGFSESLSKEVAPFNIRVLIVEPGAFRTNFLSAYATPAAGLNPAYEGTTIDQVLQLFQSRSGKQEGDPVKAVERIIDVVQGTGVGAGKTSCLRLPLGRDCIARAKTKLEEVRKNLDEMEEIACSTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS18</accession>
    <name>B0XS18_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_025610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025610"/>
    <dbReference type="HOGENOM" id="CLU_094306_0_0_1"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24685" checksum="6AD881B96E18FAD2" modified="2008-04-08" version="1">MEARSLARCLRLRPTTSLYTRQPIIFRGQDALRYFSTSNSLLQTPPASQDQPSSTTPASPQDQSKVQTSSSNSTASNSDSADFDRILDQLNFNNANRNATEDSQSSDSLSLSRSVSMAAGTESYKQPLRRVELKLGPTLGRQVHVEPEKGLDLTTALRVLQGNVTTNKVRAQWYAQKFHVRRGQMRKNLRMERWRKLFKFSFKQTVNKIQRMRAQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS25</accession>
    <name>B0XS25_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">AFUB_025680</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS25"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025680"/>
    <dbReference type="HOGENOM" id="CLU_008023_2_1_1"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="PhylomeDB" id="B0XS25"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.560:FF:000005">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="188"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EDP54511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="462" mass="50940" checksum="AB8AB282E34F0F37" modified="2008-04-08" version="1">MNQDSPLMHRAYIALGSNVGERVEMIEKACKEMERAHIRVKRTSSLFETAPMYVLDQDPFMNGVCEVETSLGPLELLDKLQSIELALGRRKLIDKGPRSIDLDILLYDQEVFSHERLNIPHKLMLERDFVLRPLCQLIPHELPPIPGQTRSYLSYLKSLPPPEPVPVATTHISPRFPALRSTDPKRPTHIMAILNVTPDSFSDGGKHFSQDLSALTETVRHLIAAGATIIDVGGESTRPGSAPVGEAEELARVIPVIRHIRTSIPEANNIAISIDTYRAKVAEEACAAGADIINDISAGTLDPEMLPTMARTGKAVILMHMRGTPATMTKLTDYPNGIVQDVGAELRARVAAAEAAGIRRWRIILDPGLGFAKNMPHDLAILRDLQQFRTGIEGLEYFPWLMGPSRKRFIGRLTGVEKASERTWGTAATVTASIAGGADIVRVHDVREMWQVAKVADAIYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSL8</accession>
    <name>B0XSL8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_027650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027650"/>
    <dbReference type="HOGENOM" id="CLU_2096337_0_0_1"/>
    <dbReference type="OrthoDB" id="10329136at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="116" mass="13719" checksum="3DD0ADA5137309BE" modified="2008-04-08" version="1">MHSLISNPDREEGSANWAQELLILRSCCRCHIPPSDWLQFRRNCPSQVTNRCVSLCAWQRFTIIIKKEKRRKIDEEEEERNKERQKNKVKDIPIRKDPNDSVSSQRRAPLPSHHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSM9</accession>
    <name>B0XSM9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZIP metal ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_027750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027750"/>
    <dbReference type="HOGENOM" id="CLU_028824_0_0_1"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="PhylomeDB" id="B0XSM9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="389" mass="41925" checksum="6ECEB0C232231C06" modified="2008-04-08" version="1">MEGLFTLLALSIVMAITSFVVGSLPLAFTLSPSQLRLISSLGMGVLVGTSLIVIIPEGVDTLYSANSHNDRKGLSTRSMPAVEWQHRSFPDVAAVDFSNSNKEADSTLPLIQTVDIRRDDKSELRQREDEDDSNMDEHNGHKEENSSHAWIGVALISGFILMYLIDKLPEFATPSKQQRPPYHISLDNLGSGLRRNPSPSREGELLDAGSTSSRSHSFATTTGLVIHAAADGIALGASTSDTGLSFIIFLAIMVHKAPASFGLTSVLLKQGVSSRTARAHLVVFSLAAPFGALATFLFVRIVGSGSSGDEAATLWRTGMLLLFSAGTFLYVAMHTMQENSPNSELRELPINGYGDSRDIPTKDDKSMRDLVASVIGMILPMFLQLGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSN7</accession>
    <name>B0XSN7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_027830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSN7"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="PhylomeDB" id="B0XSN7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="676"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="863" mass="95266" checksum="27870BC1CF2D5EE7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSS7</accession>
    <name>B0XSS7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall cysteine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_017450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017450"/>
    <dbReference type="HOGENOM" id="CLU_017590_0_0_1"/>
    <dbReference type="OrthoDB" id="7250310at2759"/>
    <dbReference type="PhylomeDB" id="B0XSS7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF2">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758306" evidence="1">
        <location>
            <begin position="19"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="606" mass="65283" checksum="60112A53A7139573" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT20</accession>
    <name>B0XT20_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_028580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT20"/>
    <dbReference type="HOGENOM" id="CLU_036529_1_0_1"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="273"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="381" mass="42187" checksum="ECB07816DFF93789" modified="2008-04-08" version="1">MSTRRSLRSRPMRDDQSSIDSDLSPRRTRSTRGVPPAPLVTVTRSVSGSAENPIRSLFLTVRMPSSKLREVTGGSARGSTSTRRSHNVFTENPIITGPRSSRPKRKLVEVSTSEGDDLADQEEDEVDEDAPGEDDVDADGDLELDDAPPRPPTSKRNAKGTATSTGKSVKSVEEKEMELEEEDDEDDDELSELDTDAEGEPDDQDESGLGNGNGGDEDLDEEDEEDEEDDDSEEVTPGGDLSRLTKRQRGTLGNDFLQLPMEPQVKKHLTAEERAMRRAEMARRRKNLSEKRNEEEKMDTINRLLRKQAPKRRGRIPVAEAEANAAEAEAEEAEKPQPTMVRWVSGREGSRIGVPEEWLGTPAGRVFGETPSRPSKLVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTC3</accession>
    <name>B0XTC3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_028920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028920"/>
    <dbReference type="HOGENOM" id="CLU_1094061_0_0_1"/>
    <dbReference type="OrthoDB" id="4360387at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="254" mass="28835" checksum="C21363E54B36E999" modified="2008-04-08" version="1">MRQEKQDKSSIPYAWYWHGKPLRTGLAQGEKIRPVCTGSHILQTSDHGTADRACCSSNIPDKQSYPCGHGHGNNAENHHWIPESPQQNPNSCSSGVQQPRPCGSEGQQGEIPSCSAPTFTCQGCARDTSRPEPCSLDRYCTCTAESTCLPGYPYGQSYPASRCRFYPHPKPDISGSDSPRPRSHYPSAPVKCQQSFTRFESCDRFDCCEDTFFSKCEYSTEESMRTDHDYDADFETRSYHRRRPWVNRQVHRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTF3</accession>
    <name>B0XTF3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosome biogenesis protein (Bms1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_029210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029210"/>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="PhylomeDB" id="B0XTF3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="62"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="403"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="564"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="638"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1182" mass="134292" checksum="523D3324E9B0CD63" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTQ8</accession>
    <name>B0XTQ8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tafazzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_029600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029600"/>
    <dbReference type="HOGENOM" id="CLU_032824_0_0_1"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="PhylomeDB" id="B0XTQ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="64982" checksum="9A6A7419A2DAD394" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU01</accession>
    <name>B0XU01_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_019690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019690"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="PhylomeDB" id="B0XU01"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000124">
        <property type="entry name" value="Putative aspartyl-tRNA synthetase Dps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="243"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP53923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="555" mass="61627" checksum="E0BF438B07E89C4C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUG3</accession>
    <name>B0XUG3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_030790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0XUG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030790"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="PhylomeDB" id="B0XUG3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005285">
        <property type="entry name" value="Drug-R_PDR/CDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
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        <property type="entry name" value="3a01205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1225"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1269"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1315"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1349"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1465"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="166"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="857"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP55018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1499" mass="168695" checksum="2C54143DFF3C8446" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUI1</accession>
    <name>B0XUI1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_030970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030970"/>
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    <dbReference type="OrthoDB" id="435022at2759"/>
    <dbReference type="PhylomeDB" id="B0XUI1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000013">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF4">
        <property type="entry name" value="CITRATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="433" mass="48565" checksum="58D576CCF4EC5210" modified="2008-04-08" version="1">MSFGTLHIRDSRTNAEYEIPIRRNAVVAMDFKRIKAPAAGADRADQVDSGLRVHDPGLQNTTVVETEISFSDHWKRLLLYRGYTLEQLWDSDFEDMLHLLVWGSYPTALQKKELSRKLSEEMTMVPKSVHRTIETLPRTTSPLPLMLVGLSACLAYVPESIPASTKPDLYQSNSNVLDRAIIRTVAAYAVVFGLVNCHRRGIPFAQPSRHTSYLENLFHLAGLVDQTTGRPDPTKLSCFQRFAMLNADHGMALSVFSALVTASSLTDPISCLITATGAAFGPLHFGATESANLALRVIGTPENVPNFIEEVKQGKQRLFGYGHRSYKGVDPRVAPIRSILKDLDMSSNSLLKVAERIEQVASADDYFRNRGLYPNADFYGNFVFTEIGFEPDMIPAAMMAQRIMGVMAHWREYMCKPLQQSVRYRRVSHIDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUI4</accession>
    <name>B0XUI4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AflR-like C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_031000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031000"/>
    <dbReference type="HOGENOM" id="CLU_026573_0_0_1"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="PHI-base" id="PHI:123466"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF26">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="532" mass="59000" checksum="31E5D7DA2008DE2A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUR1</accession>
    <name>B0XUR1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_020960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020960"/>
    <dbReference type="HOGENOM" id="CLU_013173_1_4_1"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="PhylomeDB" id="B0XUR1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000162">
        <property type="entry name" value="Protein serine/threonine phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760209" description="protein-serine/threonine phosphatase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="322" mass="34942" checksum="3DA85A1012BC5408" modified="2008-04-08" version="1">MFRNTILSTSDALLLFDAGAGQVQGGRPFQEDRCTFVLPDQFPSQTNDKLTYFAVYDGHGSELVSDHASRNLHLLLAKRPEFDQGDYEAAIRGALIDEDAVLLETFNNLTTEPAVSGSTVALCFVNLTKGDLVVANLGDSHVILAERDNRTDHPSHIRRLSKSHKPDTPDEKARIEDAGGAVNTRRGTARLGSLNMSRALGDLQYKNPINNAGDEYSSSKTRRASASTSAPETRGNFLSVEPHMTRMTLSPDRRYLVVVTSDGVSDNIDDATLIHHVMRLSMRGMRAGDIAQEIATTAAAQKAKEGSDNASCIVALLDGQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV49</accession>
    <name>B0XV49_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_021650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021650"/>
    <dbReference type="HOGENOM" id="CLU_016574_7_2_1"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="PhylomeDB" id="B0XV49"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF18">
        <property type="entry name" value="MALTOSE FERMENTATION REGULATORY PROTEIN MAL13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="511" mass="56342" checksum="7CBA3F3B3F1DE9A3" modified="2008-04-08" version="1">MRRQLTKRACDECISRKVKCNGSSPCDTCLKTSKEADCTYLKPPGRRGPKAKRYTSKSRSACDGSIGHAHTEEAAARTQSVENRPAIPADVHADTERDESLSSCISKTVLVYIVRLYQTFSYSVWPVVDADAVLQQLGNGTCDAQTLCLVLALCAATMAQLQLAPMAGDDGHMVDSSQLKSACMQLRERSDYRENLDVKGVLVSFFLHVYHAKINQRKSAMLFIQEAIASARLLGLDTNERNAVVTDGVVANREIVFVLLWVSERGYAMHLGVRPSYSDPIQVPDAAQLAVDPHARGLLELFSLFATFDQIREQRCRSGSLAQAVSPSSLAETEAALSLLAFNSDHQASTRLADCYITREWMRTIVWQEALSGHLLSSTATTEVMTFRFPVIVGRDLLVSLHGLSEADLLPLGRDQLLKCFEVANSLADIILHTPPSSFSSAFEFGPPDFLHALYQKILPFLEHDPMLNSILRAKTAEALVMAPARLSVGLVARLDMEEEESISQQNDRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVI0</accession>
    <name>B0XVI0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_022320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022320"/>
    <dbReference type="HOGENOM" id="CLU_044876_0_2_1"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="PhylomeDB" id="B0XVI0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF2">
        <property type="entry name" value="ISOFLAVONE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G05290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="311" mass="34156" checksum="4D318B908DE8FD19" modified="2008-04-08" version="1">MPKVAIAGGSSPTLGASILAALSTSTNWTPVILSRQTNNPKQSPEGIETRYVDYTSHESLVAALQDIDTVLSVVLIPGPESITYQLNLLNAAIEAGCRRFAPSEFALREHAQAQVDLLQPKNVVWEAVMRKVEGKQIDAARFPCGMFMNYLGIGVGGEKEKEARAGFAEGAFLVHLDAEPAYVVVPVREDGSSPTLTLTDIRDVGRFVAAALDMEEWGGRELGMAGDTVSFDELVRLCERYTGKKVEVRRVTMQQLEDRLKEIPEADVLRRMDCQIAMACARDSSVVPGVLNEVCQVQPVKVEEFLRKYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVJ6</accession>
    <name>B0XVJ6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 64 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_022480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVJ6"/>
    <dbReference type="HOGENOM" id="CLU_021377_1_1_1"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="PhylomeDB" id="B0XVJ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="534"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="692" mass="77675" checksum="276A4EF5BAA9B56E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW27</accession>
    <name>B0XW27_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_023350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023350"/>
    <dbReference type="HOGENOM" id="CLU_2037525_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="121" mass="13696" checksum="C3AB9E089C868FEE" modified="2008-04-08" version="1">MGPRTSSCFKNITLLLTITLSFLALIFDLPQFSIEIFDPFFESSALSFAFVLLLKSTALLSFPSLYLLCKFLTCFLKSRGQIRNFPCLTSLSFVSTFANILVYHSLRFNSSIAQRSKFPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW96</accession>
    <name>B0XW96_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_024040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024040"/>
    <dbReference type="HOGENOM" id="CLU_1618614_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="164" mass="18693" checksum="49B45B703CD690BB" modified="2008-04-08" version="1">MTIVKAAVRRECDMTIIDSGLFHRCGYNHREWVTRESMLKPPEPINQVGGSMTDVRIRGRTVEVTPLLQLQGINNIYSVPWDTKVSRVVESGMGCDAQLRTTVAPTGLPLKRQYLDTWASGKLAMTIQRLIIENREDDGLLYLLHVHQSLKGHKLDALWKYIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW98</accession>
    <name>B0XW98_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_024060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024060"/>
    <dbReference type="HOGENOM" id="CLU_010194_5_0_1"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="PhylomeDB" id="B0XW98"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="372" mass="41312" checksum="97CE3C8A7A8C1D24" modified="2008-04-08" version="1">MVCILGFQEDTFIDFHHGDAKEVAFTRRIVFSRRIGFTADVFGKWIQSTILSPWKTLPLLLLAQYTAKGRQLAAERSRSFQVLQLLTLLAVLRHVNAWLNTRTLNNGVSDRYDWDREVVVLTGGSNGIGRRIAQLLGDRGIKVAILDIHSPQEDQGHLPPTVRFHKCDITSPSAIAAAAADIRATLGEPTVLINNAGVCSGKTILGGTEADTRIQFEVNTLSHYWLAREFLPHMVKRDHGMVATVASLAGYTTTPNMVDYSATKAAAISFHEGLAAELVTRFHAPRVRTVLLTQGFTQTALIGQLTPEDTWFNPLLQPETVAEQLVRQILTGNSGHVVVPGSSGWLSRNLRSFPPWFQHSMRSWLERLMRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWF6</accession>
    <name>B0XWF6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_035740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035740"/>
    <dbReference type="HOGENOM" id="CLU_364471_0_0_1"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="767" mass="85934" checksum="5676C46BF0D0A7F6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWT4</accession>
    <name>B0XWT4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_036340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036340"/>
    <dbReference type="HOGENOM" id="CLU_033465_0_1_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="PhylomeDB" id="B0XWT4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="334" mass="37290" checksum="2C1114C8B3734236" modified="2008-04-08" version="1">MLEARSPYQEGSYWYYAPNKGAPIAFALLFAASGLMHIYQCCKYNSWKVTGLLPWSATLFTAGFIMRTIGAFGHWDDLSIFIASNVLLLVGPPVYEGANFFTLGRLLYYVPYHSPIHPGRVFSTFVALGIVIEVITANGASLVANTGNSISKQNTGKALLKAALILQIALMAGFVALAIKFYFNCRRGGVLSNKVKRPLYVLLCSCTLITVRTTYRTVEYFTAASLNIYNVSDLSPILKDEWFFWVFETAVMFTNTTLLNVLHPMQWLPRSNKIYLTKDGVTEIEGPGFEDGRPFLQTLIDPFDVIGLIANKGRKEKYWDALDANEKRSPPAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWV8</accession>
    <name>B0XWV8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_036580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036580"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="B0XWV8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="488" mass="55775" checksum="4432FAC9A84E5CD0" modified="2008-04-08" version="1">MDLQSVQDLKGVLRRDFFHGYATAAAQVEGAWNKDGKGQSIWDTFAHTPGKVKDGSTGDDAVRSYDLYKEDVALMKSYGVNAYRFSLSWSRIIPLGGCDDLVNEKGIEYYSNLVDELLRNGITPFVTLFHWDTPQSLEDRYGGMLNQEKFVPDFVNYARVCFERLGDRVKHWITFNEPGVYTLAGYAAGVHAPGRSSFRDRNEEGDSSTEPFIVAHTELVAHGHVSRLYKQEFQPHQQGTIGITLHGNWSEPWDEADPLDQAAAERAREFEIAWFADPLYKTGDYPASMRAQLGDRLPKFTPEESKLVLGSSEFYGMNSYTTFFVKHKTTPADINDHKGNVEIHDFNKHGIPRGEESDTEWLRAAPWGFRKLLNWIWSRYQMPIYVTENGTTAKGETAPSPSVLNDQFRIRFFEGYVGWALARAVKEDGIDIRSYFAWTFTDNWEWAAGYTDRFGCTFIDFDSPEKTRYPKQSAYYLDNLFKHLIKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWY9</accession>
    <name>B0XWY9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Recombination hotspot-binding protein (Translin), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_036890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036890"/>
    <dbReference type="HOGENOM" id="CLU_079179_0_0_1"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="PhylomeDB" id="B0XWY9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990605">
        <property type="term" value="F:GU repeat RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035939">
        <property type="term" value="F:microsatellite binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.190:FF:000004">
        <property type="entry name" value="Recombination hotspot-binding protein (Translin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="235" mass="26406" checksum="F4909A7E6578FD52" modified="2008-04-08" version="1">MIDNAIFEDLQTKIDEETAVRDELHEIVQTLSKKGRSTQAILSRAHSTPSDQLKPVLDDATKEIIAQRDEVARLKTVADKHPFYKYNGVWTRELQNLVTSIELCAWLGGLEEFKGTGSASFLTIEEVGKFLNVPVNLKEKDAFHLTIEEYLLALIGMVEELSRLAVNSVTLGDYNRPVQIGKFIKDLFAGFQLLNLKNDILRKRSDGIKYSVKKVEDVVYDLSLRNLIPKGSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXL1</accession>
    <name>B0XXL1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARID/BRIGHT domain protein (SWI1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_037790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037790"/>
    <dbReference type="HOGENOM" id="CLU_008900_0_0_1"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="PhylomeDB" id="B0XXL1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000017">
        <property type="entry name" value="ARID/BRIGHT domain protein (SWI1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="285"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="981" mass="106976" checksum="9E81B9D61A3F175B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY47</accession>
    <name>B0XY47_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/calmodulin dependent protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_039620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY47"/>
    <dbReference type="SMR" id="B0XY47"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039620"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PhylomeDB" id="B0XY47"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106057">
        <property type="term" value="P:negative regulation of calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="394" mass="44338" checksum="D024683EC90AC1EE" modified="2008-04-08" version="1">MASQTQTGQRPKVQPCRYKTGKTLGAGSYSVVKECVHIDTGRYYAAKVINKRLMAGREHMVRNEIAVLKRVSMGHQNILTLVDYFETMNNLYLVTELALGGELFDRICRKGSYYESDAADLIRAVLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKSGHGKPVDIWAIGVITYFLLCGYTPFDRDSNLEEMQAILAADYSFTPLEYWRGVSQSARDFIKGCLTVDPKARMTAHEALQHPWINPPYDLNNDSGSGEDLLPTVKKNFNARRTLHKAIDTVRAINKLREGGGLMMDGVMSLDPKPEHVNGNEVTEEQHDGRMEIDSRGDARGQTEQQIREQERKVKETVAGLWSQSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYA2</accession>
    <name>B0XYA2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_040190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040190"/>
    <dbReference type="HOGENOM" id="CLU_012162_0_0_1"/>
    <dbReference type="OrthoDB" id="5411560at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111688" checksum="DD318C6910C0E09D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYM2</accession>
    <name>B0XYM2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_041400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041400"/>
    <dbReference type="HOGENOM" id="CLU_008110_2_1_1"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="PhylomeDB" id="B0XYM2"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP52968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="593" mass="66972" checksum="A217C2AF8D75FAC2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZB4</accession>
    <name>B0XZB4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_043800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043800"/>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_1"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="PhylomeDB" id="B0XZB4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="51"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP53210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="377" mass="40562" checksum="A464C79EC73316DB" modified="2008-04-08" version="1">MAAPRLFRPAARLLSSRLSATPFRSTFQKSACAPSILRARGYATESGTKEVTVRDALNEALAEELESNPKTFILGEEVAQYNGAYKVTKGLLDRFGPKRVIDTPITEAGFCGLAVGAALAGLHPICEFMTFNFAMQAIDQIINSAAKTHYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGSIPGLKVVAPWSAEDAKGLMKAAIRDPNPVVVLENELLYGQAFPMSEAAQKDDFVLPLGKAKIERPGKDLTIVSLSRCVGQSLNAATELKQKYGVEAEVINLRSVKPLDVETIIQSLKKTGRLMCVESGFPMFGVGSEILALSMEYGFDYLTAPAVRVTGAEVPTPYAVGLEQMSFPQEDTIVGQAAKLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZS9</accession>
    <name>B0XZS9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-chitosanase</fullName>
            <ecNumber evidence="10">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_034250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="10"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034250"/>
    <dbReference type="HOGENOM" id="CLU_041930_0_0_1"/>
    <dbReference type="OrthoDB" id="4756206at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF4">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122541" description="Endo-chitosanase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="344" mass="35169" checksum="938C146639E5249A" modified="2008-04-08" version="1">MPSTTIIRQLAISLALCNSALGQVVNGADYNKPNGGPPASFFAAASTMPVAALQAAAAKATKVPSLATYPVSQDKGAAKSTIHTDWASFSEGASISWVADMDVDCDGLNSGCQGNPDGQPQTNWGALSAYEVPFIVIPDKYLSANSGALPGNNIAAVICNGKMFYGILGDSNGDSPQVTGEASWLMARTCFPNEGLNGNNGHTGVDVTYIVFTGKNAVLPSSALTKNYITNFTTLRSMGDKLVNALVSNLGLSGTPPTKTTTRVTTTTTKPTSTASCSWAGHCLGASCSSDDDCADALVCTAGKCSVDGAATCSWEGHCEGASCSSNDDCSDDLYCKSGSCTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y011</accession>
    <name>B0Y011_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_045240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y011"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045240"/>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="PhylomeDB" id="B0Y011"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760741" description="Phosphate transporter" evidence="9">
        <location>
            <begin position="22"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="569" mass="62555" checksum="8F4291A65A81F939" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y014</accession>
    <name>B0Y014_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_045270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y014"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045270"/>
    <dbReference type="HOGENOM" id="CLU_019268_1_0_1"/>
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    <dbReference type="PhylomeDB" id="B0Y014"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="256"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP53352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="561" mass="63552" checksum="7F8506DE8A2F2C17" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y049</accession>
    <name>B0Y049_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_045620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y049"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045620"/>
    <dbReference type="HOGENOM" id="CLU_037452_0_0_1"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="PhylomeDB" id="B0Y049"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50266" checksum="F311C7B577962DAA" modified="2008-04-08" version="1">MSGARSTRPSPESGFTKVTCIPGQPFDQEIRSALARLNLNFQVPHVDFAGGEVYLVGNEIGLSGRFINNVCVPVAKVLANSSQSSLVIGDVQAFLLTPEVVPDVSIGVTMKNDDGITEVKVVGEFKTFWTLELAELSVSDPISRVQLAPHLGQLVAQMRSFELRYGFLSTYQRTIFVKRTADFAFHVSRPLCALDTNLSVRQCFAGFCILAEQGYNYTEHADFKAERIDLQASVRQTPRRNHVAERSLVTGLTGNITPNSIILSDPRGALAILNVSRMISRPSETDKAIFEIDQQGTRYIVKCWGPKLEKESNAECAVYERLSESRPGGYDVFANIILAGNILCSSLFPDGRALVLPYRDGQILGYIWDELDIHERTHVREECEKAIHILRSLSIYVPDAGKHNVLFDRQTGTVTMLDFETAIECPQSEHMPYVELLSLFGDSTMRGRARGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y056</accession>
    <name>B0Y056_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_045690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y056"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045690"/>
    <dbReference type="HOGENOM" id="CLU_065853_0_1_1"/>
    <dbReference type="PhylomeDB" id="B0Y056"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="196" mass="22032" checksum="1FE9B3FB27CFDDEC" modified="2008-04-08" version="1">MFLPPVHAETDTAVLLQFIRENPLGLLITGIKSSQNFLQCTHVPFVLDTPEESTELAPKGRLRAHIAKKNPQVTAMIEGLERKPSVLDIEDSLWQIDDLSQYMERSVMGYTGGKNPQPWTVSDAPEKYIEFMQRNIVGIEIRIEEIQGKFKMSQEMKPGDREGVVAGFAQMGGETGEAISRLVRQRGALHDLKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0S6</accession>
    <name>B0Y0S6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_058380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0S6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058380"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_1"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0S6"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="13">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="371" mass="40623" checksum="C7A5BEB2FA78F49E" modified="2008-04-08" version="1">MSAGSVLVTGGTGYIGSFTTLALLEAGYKVVVTDNLYNSSVEALNRIELICGKKAEFVQLDVTDEAGFDKVFEAHPDIDSVIHFAALKAVGESGERPLDYYMVNVYGTLCLLRSMVRHNVTNIVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGNTKFAVETAITDVINAQRNNATKAGKADEAEKWNAALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVFGDDYASHDGTAIRDYIHILDLADGHLKALNYLRANNPGVRAWNLGTGKGSTVYEMIRAFSAAIGRDLPYEVAPRRAGDVLNLTSNPTRANKELGWKAQRTLEQACEDLWRWTKNNPQGYRQQPPAELLEQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1T2</accession>
    <name>B0Y1T2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_060750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060750"/>
    <dbReference type="HOGENOM" id="CLU_016218_3_0_1"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1T2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="556" mass="58217" checksum="AAF6A1B6B1BA4610" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1Z3</accession>
    <name>B0Y1Z3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_050350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1Z3"/>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1Z3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="209"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="405"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="497"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="9">
        <location>
            <begin position="770"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP51033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="870" mass="99401" checksum="240D7D2B9EDE8471" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y293</accession>
    <name>B0Y293_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ulp1 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_061720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y293"/>
    <dbReference type="HOGENOM" id="CLU_278476_0_0_1"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000014">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="871"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1086" mass="120156" checksum="E1B6C40B20EF6ECA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2D0</accession>
    <name>B0Y2D0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-binding oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_051020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2D0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051020"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2D0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08243">
        <property type="entry name" value="quinone_oxidoreductase_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="331" mass="35676" checksum="29E2FE25918BFC08" modified="2008-04-08" version="1">MSLMKAIILHTPGPPDTLKLTHHPIPIPEPGELRLRIKAFGLNRSDLLARQGRANHPIAYPRIPGIEAVGIIDTAPGLEDTFPPGSTVATAMGGMGTVFDGGYAEYVCVPARQTQLLQPKTTLPWEILGAIPVMVPTAWGALIRSLGLRARDRLLIRGGTTSVGLAAAAIAKAHGAYVASTTRKKEREAMLLENGADRVWTDDGAVAEQIRDADSGCYYDKVLELVGTATLADSLRCVKKGGVVSLVGRLCENGDLEKVDLMELIPSGVKLTVYQGTSEDFMNTPLDAVLRLIEQGSLKFKIGRVLRMEQIVEAHRCMEENEAEGKIVILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2X3</accession>
    <name>B0Y2X3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_052180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2X3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052180"/>
    <dbReference type="HOGENOM" id="CLU_023050_0_1_1"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2X3"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000008">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000023">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="493" mass="54806" checksum="F9688F7DA1B114F3" modified="2008-04-08" version="1">MVYIGIPKNYTASPSSFAGTPSLTINYEATQDLDSTNAFEGPEKLLEVWFAPSAQELGPAQPAGLKAVPEEIWKDMLDLVNCQVLSIVSSEDVDAYLLSESSMFVWPHKLILKTCGTTTLLSGLPRILEIAALFGGFPKSTAPSRGISVAAAPYRVFYSRKNFLFPDRQRGPHRSWRDEVRTMDKLFLNGSAYMIGKMNGEHWYLYLTEPHTMLTPPTSPGAKTEFTETETKVLSVPQGAALQTDSEDETLEVLMTDLDEENAKQFYLENATAVAENRYRNSNSEKSDHVDVFSNTSSDISDFDSDGSQVLPPELTTEGHALGTVVSEACGLSSVYPKEKYPDSRIDAYLFTPCGFSANGVIPPPEGKAGTHYFTVHVTPEPHCSYASFETNVPHSQNGQTTAGIIKQVVDIFKPGRFSVTLFEAKPALSQVEDEWKEAKYLAARRTAKMEHVEGYRRVDRIVHDLDGYELVFRYYERLDWKGGAPRLGEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y364</accession>
    <name>B0Y364_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein Nap1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_053090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y364"/>
    <dbReference type="HOGENOM" id="CLU_038841_1_0_1"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="PhylomeDB" id="B0Y364"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000511">
        <property type="term" value="F:H2A-H2B histone complex chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098841">
        <property type="term" value="P:protein localization to cell division site after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000004">
        <property type="entry name" value="Nucleosome assembly protein Nap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="423" mass="48336" checksum="12B9512C69503009" modified="2008-04-08" version="1">MSEPIRNKKADFPVAPTPQNTPANNAPISSHAQQPGVASIKEESLDHATAASLFARNPGLVSMIQGKLGSLVGRSSGYIESLPAPVRRRVAGLKGIQKEHAKLEAQFQEEVLELEKKYFAKFTPLYQRRATIVNGAAEPTDDEVQAGKEEEEEEEVDVKAEDERKQEEKDITTPGIPEFWLSAMKNQISLAEMITDRDEEALKHLTDVRMEYLDRPGFRLIFEFAENEFFTNKTISKTYYYKEESGYGGDFIYDHAEGCKIDWKADKDLTVRVESKKQRNKNTKQTRVVKVTVPTESFFNFFSPPQPPTDDDDTIATDIEERLELDYQLGEDIKEKLIPRAIDWFTGEALQFEELGDDMDADEFDDEDDEDEEEDEDDDDDRRSDRDVDDESEEEVRFFSLYASKYIFASTPFFTTMTALPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3G2</accession>
    <name>B0Y3G2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_054090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3G2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054090"/>
    <dbReference type="HOGENOM" id="CLU_110455_2_0_1"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3G2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="138" mass="16173" checksum="615408B43E3AFCDB" modified="2008-04-08" version="1">MSTILRTLRNLRRIGLKEYGHQMQTQFIGDTKAGTLIATDRYGNKYYENMEEELPLRTRWVDYKEKEYDPSQIEPGWHAWLSYMVDAPPTQDKILQTGLRAWELPEHRPNPTLSRGAYKPYSTVKPKYSAWTPVAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3M7</accession>
    <name>B0Y3M7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_054760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054760"/>
    <dbReference type="HOGENOM" id="CLU_644006_0_0_1"/>
    <dbReference type="OrthoDB" id="4188313at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="468" mass="51808" checksum="142BACFC8FC3CD2B" modified="2008-04-08" version="1">MESALPRRKSIRARHSLLLLFGPQDSGSARREGCSRYYDLKHTPFIFRRRSVLIERRKISPQLERQIRWSCVLLAKSIEQEEFELDLRQTQNSHDAASPREKDDIHPAASTPGEQNQCNHNIRKYDSAIELDTQQVPSLTNEFPSASPFQDLHEFDSGSKHDSSASASSPATTCSDMTFCTGLSSVEPSLKSLAPTVQGQQSAPEEIFTECPPVQSDEAFLAGESSPNLSDEETISDDVEVFFNPDNTRFNLGRTPSLSRPCTKATQLNHKPRFKHFPAVPQSDTTEAHETSGGGTPLKPGEFGATCIRKRDDEPAAIVDSRGVVHIMTDVEEAQRNSDLELAVMEKMKTGVIRCSVTSPADGEAAAPLSKSDKHPLPASAKRKTSSFWSLRSLISRESLGSLKRHAKERQTQSPSRSRSQSVSLAESQLPRKSPSLLRKMSVLDMGRHRPISASRNKDTTGFNRIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3Z1</accession>
    <name>B0Y3Z1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">37S ribosomal protein S35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_055930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3Z1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055930"/>
    <dbReference type="HOGENOM" id="CLU_049223_1_0_1"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3Z1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43127" checksum="00B5BCD204703E0E" modified="2008-04-08" version="1">MPPRIQNQLVSGSLLPYLSSTSSTSSTSSTCISKLSQTCSSRPFCSSPAAQTRLRNEMFAWINGEGAQLKQHTPGRTNYITRLKGNAGNRPFPLNPNFVSEPILSEELRNEIHRRVVDKKQSVRAVSVDLGVDMRRVAAVVRLVELEKRWKQQGKSLALPYARAVHEMVPTTPLRNDLNIRPHESINDLPVHRLTDPQIFYPVSESRQFTRVDAGRVFSAAPALPHKEAERAVAHPDEAISKITQDPARIERVGKGDDEQQVLQPADVRIPHPHLVSHERQVKSNPNEFRENMKLYRERLQQEEAIEQERKRLAKERAEQRLVRVQPEGSRFEFRIKDVVVSRETTGTDGRGAQAPGRRYGVPTYDRKKGQIKIPTRVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y406</accession>
    <name>B0Y406_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin AspA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_056080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y406"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056080"/>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="PhylomeDB" id="B0Y406"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="354" mass="40342" checksum="F1A8BB33528ABFAE" modified="2008-04-08" version="1">MVCGASGTGMFQSSSTWPLFPILTWYLLCTGRTTFVNTLCGKKVLESKDADDAASAHIEEGVRIKPVTVGNFGEIVGYLERQYDDILAEESRIKRNPRFRDNRVHVLLYFITPTGHGLRELDIELMKRLSPRVNVIPVIGKADSLTPAELAESKKLIMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEDFVEIDGRKVRARQYPWGVVEVENPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVDGAAAGHDSSMNPEDLASQSVRLKEEQLRREEEKLREIELKVQREIAEKRQELLARESQLREIEARMAREASQNQMALQPEAANGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y425</accession>
    <name>B0Y425_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_056270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y425"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056270"/>
    <dbReference type="HOGENOM" id="CLU_034009_0_0_1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="PhylomeDB" id="B0Y425"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="174"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="443" mass="49744" checksum="A272EEBC09A6954C" modified="2008-04-08" version="1">MARRAADKRVNLAVSRIIPPILIGVFGYASYAITKPLCVDYLIHPAHHYDRRSRSGAGAAILAIYYVLLIPVLATYLRLLYNVVLSPGYLPRGTACTQNQTGSDGSKHRHRRHRRRKSGHHLSKTTEKTDRSDGGDVERGLEYSARAKAYPLDAEGLESFYTKDVFVCQPDGRPVYCSTCCQFKTDRAHHCREVDRCVRKMDHFCPWVGGVVSETSFKFFIQFIVYTMIYCIFVLIVFAIYTAELRREAGRTNVHWIVCLALSSLFGFFTFGMAISSVQLAANNLTTIENLNRRSAVWTLAIRVPRHILSKRWAPTFRTITYPLPPVPPAESEVARESPGGEQHVFAILQTLPGENPFDLGSPLKNIQQVMGFSLLEWLLPIKQSPCADHSSNESAFALGPVVTRLKKEAGLEVSTESESADPVGAAETPQHEQRRGKHRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y443</accession>
    <name>B0Y443_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_056450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y443"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056450"/>
    <dbReference type="HOGENOM" id="CLU_067588_0_0_1"/>
    <dbReference type="OrthoDB" id="5372734at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="39355" checksum="2D53031072F02813" modified="2008-04-08" version="1">MSDDECLDEYDDEDVFWIEEPDPTVADDLAEAATHDALYFDDPSLDVEDFYSDWDELSDDYYDDDPTVEKRRRMMDITKNNGYSGELLGNIERPGLLEQKTLVHRQHRGGVVAESPSFKTDQASFQAVIWKSSDDKKNPVTLYEPGDGEKVALLKNWREVFRNSHPALRLRKLSHIKANKEHARSRLIGTISQKEGQKEDNSDCTSGASLDNLRETDAASDNSLASTPPESVPSIPLHRIRAMESMASVPFVSELNDFTSSLEDQEMDDITTKQGDAEPTDVAGNDSSLSSRKHRKRKASDLEEEHQHNNTDASKRLRSESNVLNPAGKKGTGATPSPGAGRKSTRQKTNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4G6</accession>
    <name>B0Y4G6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_069020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069020"/>
    <dbReference type="HOGENOM" id="CLU_2782656_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="69" mass="7627" checksum="FBFC5A2D6AB0557F" modified="2008-04-08" version="1" fragment="single">MLVLAVNRPQAAEQIGEHQDPKDAAWLTQSDSHLSSIFMPFIVFSSVLSIVVFIIHLSLLLKCMDCTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4S7</accession>
    <name>B0Y4S7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_070150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4S7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070150"/>
    <dbReference type="HOGENOM" id="CLU_067876_1_0_1"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4S7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21093" checksum="83B62894B23EFAC2" modified="2008-04-08" version="1">MWLSAKQITPFPLTWVRMSPVNSLWFKWKSLRLPWRRSFLVGTDLSGNTYWEFKDSLNAGRYRRIVKYNSKTHYADVQVTPQWHQWLRYVRADPPSLEEQQQDVIRQIQIKKLAQLADMRWASKPSYLDKPQTQQPGPATRTSDATLHPPMGAVGEGPKPVAHLTGRTLTGIFTPVACVNGSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4U6</accession>
    <name>B0Y4U6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_070350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4U6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070350"/>
    <dbReference type="HOGENOM" id="CLU_489988_0_0_1"/>
    <dbReference type="OrthoDB" id="5355510at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="64720" checksum="9F189EAC9397A250" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5G8</accession>
    <name>B0Y5G8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General amino acid permease (Agp2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_063350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5G8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063350"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5G8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902274">
        <property type="term" value="P:positive regulation of (R)-carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902269">
        <property type="term" value="P:positive regulation of polyamine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="82"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="556" mass="61294" checksum="208A2136DC9303A3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5W8</accession>
    <name>B0Y5W8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_064850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5W8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064850"/>
    <dbReference type="HOGENOM" id="CLU_099502_3_0_1"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5W8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:7770001">
        <property type="term" value="C:mitochondrial pyruvate carrier complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050833">
        <property type="term" value="F:pyruvate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="125" mass="13695" checksum="C0A47A01936DF565" modified="2008-04-08" version="1">MAAAIKAINAKIRSNKVLDYVCSTHFWGPASNFGIPVAAVMDTQKDPEIISGKMTAALTIYSATFMRYALAVSPKNYLLFACHFINCSAQMTQGYRYLSYWNWGGREAKLAEAAKQGKEVTEAGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Z6</accession>
    <name>MIC60_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>MICOS complex subunit mic60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mic60</name>
        <name type="ORF">AFUB_065130</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Z6"/>
    <dbReference type="SMR" id="B0Y5Z6"/>
    <dbReference type="EnsemblFungi" id="EDP50181">
        <property type="protein sequence ID" value="EDP50181"/>
        <property type="gene ID" value="AFUB_065130"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008024_1_2_1"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Z6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000406645" description="MICOS complex subunit mic60">
        <location>
            <begin position="42"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="118"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="295"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="624" mass="69525" checksum="9FAE6B206F25B61E" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y648</accession>
    <name>B0Y648_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_065650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y648"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065650"/>
    <dbReference type="HOGENOM" id="CLU_025951_1_1_1"/>
    <dbReference type="OrthoDB" id="4179303at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56911" checksum="D8E406B98675C146" modified="2008-04-08" version="1">MNHARHIYDLADELLSEILSFLLELDTPMKRASQTYYQREPQCTGDAHLHLYGEKSDLDRFRLVCKRFRRIGAPTKFRRFVLRFSRNEFGRLEDFLTMQLACHVRYFTYMVRPFYTENGWPLILTEIEKTDPPLFNTIKHRLQDQQQIIQENQDLLLLRRAIASFSGLQQVKLLRLQDEADELLMGHNQRGSMERSAMLEWEPACTRAVTNLAISLLESNCTSIRFVGPQMSSDSMIKLLQTPPMIFSALGARLLSLDITFQSYTGMATTMSNVSSVFYDFFQAARNLTAVHFGVPGNGSVFLPLKQMLYRVQWKRLQTVSLQGWCLEADDIITIFLQHKLQIRDIRLINVHLRDGRWRDVLACLREEMEQLERIDLHDIDYVRRTQSADHTNGSSSRHSNGSGAGLGMIEAIPALSLVSHLPSGPPQPVTFDDDYMSLAPRGTSRRSIPKATMQKLRTLTVDDLGDDGVAVKREQIFLWEAWILSSSRTSFSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6B8</accession>
    <name>B0Y6B8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_066380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066380"/>
    <dbReference type="HOGENOM" id="CLU_597279_0_0_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="484" mass="54440" checksum="FDD558F78BAD19A4" modified="2008-04-08" version="1">MTAIDLANWMKYLDPSVRVIDSYISCSHDASAYKYDGGDNVMHEFVGSICQSADYTGQLLAGSRWFDLRVTRDGNTLVTKHGIITFQPFETVLYQIKNFADSHKSEFIFLDLDLAHEDGVGGDVLAMLIKVLGDGKEDAFATAHVGPDGKMYNTDLTWAKLREDGKQYVVIYGEEEKVNGETKHYDSGKYWAPQAGNIRDNWADDYEDKSPQEIVNWLDQVLAQWKKEKLWITQLIDTPKRSYMPGHHPSDCDSRAAPVFTGWLTKFKPGDKLGIVKRDFVNEGWNEPGISHVILLNKFTQSPVLPLGPTINYLSTIRLRTLDGRYVAVDSNPPGNTNLSLLTLVNAPTDNTRFLIRHYQRDSSWEWPFSGNLDADSCNANGNVRLVHVDSRVGDDTVVSCAKNSGGFMYWGVGWGPADDWETFLPYDPANPRSSAKIRDGSVIVLRTLWHMYWKAGNDENLYTRLNASTGAIEDATRFVVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6K7</accession>
    <name>B0Y6K7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_067300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6K7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067300"/>
    <dbReference type="HOGENOM" id="CLU_013808_3_0_1"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6K7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000512">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="549"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="553"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="647" mass="70883" checksum="18F9927C04355CBE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7D9</accession>
    <name>B0Y7D9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNA excision repair protein Rad2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_073470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073470"/>
    <dbReference type="HOGENOM" id="CLU_003018_0_0_1"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7D9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000092">
        <property type="entry name" value="DNA excision repair protein Rad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="808"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="450"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="531"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="656"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1019"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1089"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1120"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP49320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1130" mass="127309" checksum="9430FA30FD1ADD15" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7K4</accession>
    <name>B0Y7K4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_074120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074120"/>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7K4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000059">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP49385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="524" mass="59471" checksum="B2FE626BB41A4965" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7P6</accession>
    <name>B0Y7P6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FK506-binding protein</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_074540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7P6"/>
    <dbReference type="HOGENOM" id="CLU_022297_3_1_1"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7P6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="369"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="455" mass="49716" checksum="D7163216DB7042C4" modified="2008-04-08" version="1">MAAIDPDETPEFEDGQTRPRATLKLVRPPADMDIDESDDDYEEDSEEDSDDEEINGGPSDKEKARKLKEAAALKELEDEDEDDDSEGDDENFDLKAAISKLVKGKAPATDDDEDDESDEGLELDEMVVCTLDPERHCQQPLDITVAEGERVFFKVTGTHTVYLTGNYVIPAEEGPSEYDEDEDDEDDEDDYDLSPDEDELVDMGDLLDDEEEDELDGLAHPRVTEIESDEEEAPKLVESKGKNKRTADSDEEMALDDMMAKDGKAKGADNGEPAPSKKQQKKLKKNNGEAAAVEQKKEAKVAKEGKEGKEGKEAKEAKKVQFAKNLEQGPTPSGQKPGETTTGTLGVKEVKGVKIDDKKLGKGPAAKAGNTVAMRYIGKLEDGKVFDANKKGKPFTFKLGKGEVIKGWDIGIAGMAVGGERRITIPPHLAYGKKALPGIPANSKLIFDVKLLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7W5</accession>
    <name>B0Y7W5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_075250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075250"/>
    <dbReference type="HOGENOM" id="CLU_953087_0_0_1"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7W5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="33482" checksum="A26C8ECD0BF67658" modified="2008-04-08" version="1">MGRRSRPTHFTKEPSEGGSDSSGESFQFSAGESETDSSSVLTDVTVPDSPKPCAVNSGRSLPRAQNKSRPSQAQVDLPDFSDDPDDDTDEDLADVPLDYGRGLKTKQRGERIEKRWHKYCRVKAAEPNSPQKWNDPSDALRQITPNDVHRFFNYCGKLQWGIDGRRLKGLKKASALYAEWKSFQGYYRRITRQSISNDYCEEINAGLRRLIDKWELDTDEREKTPVYVQDLTEFNETTLRTQEKRFHALLSLQFKHLQFSIQRDPLGGPPIPLVEIRSKHVKKFLGISQQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7Z1</accession>
    <name>B0Y7Z1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_075520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7Z1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075520"/>
    <dbReference type="HOGENOM" id="CLU_017290_6_1_1"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7Z1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF2">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="5">
        <location>
            <begin position="118"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP49522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="431" mass="48584" checksum="FE28306289B7E458" modified="2008-04-08" version="1">MCAGLRKGAFTLLVNFLDKHPQVEFIRYQWIDYAGILRARVVPVSNALKLASTESPLCGGRICLTATNVIRMMENRSHVGVDSIYPDFSSLRECHYAPGHASVMCFISEGDMGFERDPRTLLGSIVASAPQVQFRIGFEVEFRCLTPEGKDLDDTLYSWWTTTGLRNRCAPIIDEVVRLLQREKIEVLHYCSESGLGMFEIATGPLSPLESIDAWVYTREAVKSLFWEHGIIATLYPSPVEVHTGIGAHFHLSMTSDLEVDESAFLAGMLGQLGGLCALAMPFEDSYKRVTDRKSEAGCWIGWGTENRDFPIRKVKKRHWEVRCCDATANLYLVVAGFINAGLGGLQTGKQLVWQDCNSNPVALDEETRRELGIRQRMPTDLSESLRELEKWDGGAMGKCLRTFCVMKKQEIRDLGEVSDERRLRDMIRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y867</accession>
    <name>B0Y867_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small oligopeptide transporter, OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_076280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y867"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076280"/>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="PhylomeDB" id="B0Y867"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760864" evidence="10">
        <location>
            <begin position="24"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="750" mass="83434" checksum="5F53845769DC63D7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y881</accession>
    <name>B0Y881_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RNA lariat debranching enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_076420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y881"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076420"/>
    <dbReference type="HOGENOM" id="CLU_005893_3_0_1"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="PhylomeDB" id="B0Y881"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="574"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="378"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="727"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP49612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="785" mass="87521" checksum="CF1F5C5F50B1EAD5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8E6</accession>
    <name>B0Y8E6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_077070</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8E6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077070"/>
    <dbReference type="HOGENOM" id="CLU_056971_0_0_1"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8E6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000187">
        <property type="entry name" value="Probable FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="116"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="275"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP49677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="323" mass="35746" checksum="E41B8D6C4F919497" modified="2008-04-08" version="1">MQDMRESASEPSRALSTSDGAAVNDQQPPPHYPNSPATTTKETDNIPSFPSSTTTATIVESSPSLSGVVADVHQRVQSFLQESHPPDSLLAAVQQQTRISLNVIATALSRYKLSELSLSYNGGKDCLVLLILFLASLHPHPPPEEGGLAYIPAIYALPPDSFPAVEEFVQWSSRAYHLAIVRFTTEPPRTTLKSCFEHYLSLNPSIKAIFVGTRRTDPHGANLTHFDPTDSGWPDFMRIHPVIDWHYAEIWAFIRHLGLKYCSLYDRGYTSLGGTSDTHPNPKLRVEHSADPGQGVADGTQSQHYRPAYELTEDQEERLGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8U5</accession>
    <name>B0Y8U5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_078590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8U5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078590"/>
    <dbReference type="HOGENOM" id="CLU_1204534_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="230" mass="25885" checksum="C47A6F5D4D364931" modified="2008-04-08" version="1">MLLDVFELLSLSTSHSQPAFSFSYAICFFDISPSTRPSAYTLKKCPDGLLVVFFRLTSSPLSSPSFMRPGRGYLVMLFLPGFNPADQPINCTLKPFKLRRLFPEFLLPARESGWSIWGYRYALSHSSNFPVTKIINLQRLSSAFLELFTEFGDFTEDACQLLDRYLFGAGKSNTVIIMTSAWSIWSHGSRAFRADTFGTTSANFLGQSWTWIENGFNAVKAAAQKNVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9K8</accession>
    <name>B0Y9K8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_081390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9K8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081390"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_2_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9K8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="514" mass="56359" checksum="49F520CF3E25F658" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Y8</accession>
    <name>B0Y9Y8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_082740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9Y8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082740"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9Y8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="700" mass="77876" checksum="DB2725078DA26280" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA33</accession>
    <name>B0YA33_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_083250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083250"/>
    <dbReference type="HOGENOM" id="CLU_005537_1_1_1"/>
    <dbReference type="OrthoDB" id="5315052at2759"/>
    <dbReference type="PhylomeDB" id="B0YA33"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="893"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1187" mass="129950" checksum="7B4BEAD552958655" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA34</accession>
    <name>B0YA34_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_083260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083260"/>
    <dbReference type="HOGENOM" id="CLU_012646_1_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="570" mass="63971" checksum="E3D4DD83114597F0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAG3</accession>
    <name>B0YAG3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_084570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084570"/>
    <dbReference type="HOGENOM" id="CLU_022381_1_0_1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B0YAG3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF10">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760904" evidence="2">
        <location>
            <begin position="27"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="394" mass="44555" checksum="72551BC32ADFFAE0" modified="2008-04-08" version="1">MGPQRFKRQFIVAILLAASIIWLMRSFEHEDADVARTMPLLQKYIHPPSGKGGAWYIPPSWLENATTAPESIVDAAKLASDKAQAPERQITLSSIPMIVHQTWKTTDPQTWPPPIRQSTESWLRAVEQDQMAYFLWDDEGINQFIKHFEPGLETQFYALGSNVERTDVFRILVSKWIGGVYGDMDTEPLRKPKSWINASDTQPWRDPDTGAVYRSTKPVRAIVGLEADCPPGSDLYWRMGYTHPVQLTQWAFAWAPGHPILQMFLDRFSAAMQERSNQAVDPLVLTGPVAFTEAVQSWLVATTGLRWNALTGLHDGGRSKVVEDVLVLPITGFSPGRGRYGNMGSKPVTDPSARLRHRAQGSWRKFDLLVEYGKFCRTVFGRCRNWTKVPHTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB24</accession>
    <name>B0YB24_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_091310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the BOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091310"/>
    <dbReference type="HOGENOM" id="CLU_078260_1_0_1"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="PhylomeDB" id="B0YB24"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="244" mass="27567" checksum="DB7D482CCB70F7EF" modified="2008-04-08" version="1">MNSLFNSALKQSSAIRRDLDTFSQSPATTSAALQGQIAASLASLSRTIDDYSALSKKELIPEKQEKAFERVKNFRAELADYRTHFDQLRKEREEAQSVTNRNELLGRRPHHAATPENPYAQSSLPQSSSFANTSSSRSGLSFGASPADYTRETHALREQSFFANTNSQLDEFLDRGRAVLADLGQQREVLKGTQRRLYSVANTLGVSGDTIRKVERRAKQDKWIFWGGVLVFFLFCWLVLHFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBA3</accession>
    <name>B0YBA3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_092100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092100"/>
    <dbReference type="HOGENOM" id="CLU_024934_6_0_1"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="PhylomeDB" id="B0YBA3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="402" mass="45173" checksum="632A68FB837CF8C7" modified="2008-04-08" version="1">MALKIKESQPTMRPRLAHRKSRNGCQRCRARRVKCDEARPVCRDCHRHGVACLYDRSEGQRPTAQTEQQRSAAPPPSSHPSQIALASSGYHAYTELRLLHHFTVGTSLTFPGAHLQSIKDCWSIEVPKLAFAYKPLLYAIFAISALHLYRSKSSETDLIGVRAVYLERALRDHRVCVGNIDTITADAACFTCILLLIDAFTSLQDRPLAPYRPPMEWMKLVRGSVSVFDAALRAMKGSRTARILSIIHSAPSVTDANFTFGTCGCGHFSYLLPSEDFGAGDCEQLRSPKLEIYRSTVAYINSVWLAIEAREHPAMMCRRLMVFPLIVPQEFLQLLQEMDSRALVILAHYFALSATLTDIWWIGHTAHREVLAIEKMVNGQWVTSMSWPLTTVASHCRICTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBC3</accession>
    <name>B0YBC3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_092300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092300"/>
    <dbReference type="HOGENOM" id="CLU_014819_2_1_1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="PhylomeDB" id="B0YBC3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122557" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="573" mass="62842" checksum="1883E165BAD609E9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC43</accession>
    <name>B0YC43_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_088840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088840"/>
    <dbReference type="HOGENOM" id="CLU_032674_1_0_1"/>
    <dbReference type="OrthoDB" id="5417811at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="327" mass="36530" checksum="40DA0E2FEF39FBC4" modified="2008-04-08" version="1">MELPRVSTTQQTKTSHPSLNSTSRYNGSNRTISHLQNEGQGPDYGAGRQEPHAPGQSTAPGDSGLNATVSPDTPHMPHSPVNLLRPADSSDSNGEWPSDARSTRQTQFEGSRREAAPYSQQKRSCMPALKDRVIRRRLYTLIPTTVFLLAIIAFYLAVRSATLLGQEIHILLIFMILILSIIFCHALIRFAMEILQDRRSTVARNRVPSRVGPMGYAQPDRPIQVTLAGDEEALVDGAVREKVTTPPPAYGLWRSSVRINPDLLYWRRVEENEIPPAAINDTQRRSNRNPSIPRPPSYTSDDGVDYVIQARPRPFAARHDTEDPVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCE0</accession>
    <name>B0YCE0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_089850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCE0"/>
    <dbReference type="HOGENOM" id="CLU_012774_2_0_1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="PhylomeDB" id="B0YCE0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000580">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000094">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="201"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="638" mass="69888" checksum="933FB0ADDB337361" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCJ5</accession>
    <name>B0YCJ5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_090410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090410"/>
    <dbReference type="HOGENOM" id="CLU_041220_2_0_1"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="PhylomeDB" id="B0YCJ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="48"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP48326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="392" mass="43335" checksum="9B4A60A1DE255910" modified="2008-04-08" version="1">MGKAARGKRNAPSSSPYQKPGAPLSKAASAIFKFNTDIGQHILKNPTIADAIVDKANVQPSQTVLEVGPGTGILTTRILEKAKKVIAVELDPRMAAEVTKTVQGTPAEKKLQVILGDFVKTDLSKLPPFQICISNTPYQISSPLIFKLLSMPNPPKTCILMVQREFALRLIARPGDSLYSRLSVNAQFFSRISHIMKVGKNNFRPPPQVESSVVRIEPKADRPNISWDEWDGMLRICFVRKNKTLRAGFMATKVRALIERNWITWVSMHPEKVTQADIDFLQGKDVSALQSVDEDMDMDQDGDEAVQGGDDEDDIFMDLGGETEAPVTTSKGSLVAIGDQQVPRAMVTKLVQAKIQRVLEQTNLANARAQKCDENNFLRLLHGFNTEGIHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCW9</accession>
    <name>B0YCW9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_093470</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093470"/>
    <dbReference type="HOGENOM" id="CLU_006493_0_0_1"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="PhylomeDB" id="B0YCW9"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000099">
        <property type="entry name" value="Para-aminobenzoate synthase PabaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.120.10:FF:000009">
        <property type="entry name" value="Para-aminobenzoate synthase PabaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="13">
        <location>
            <begin position="313"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="12">
        <location>
            <begin position="526"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP47503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="824" mass="91592" checksum="45FDEF3D5E28D218" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD74</accession>
    <name>B0YD74_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_094540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094540"/>
    <dbReference type="HOGENOM" id="CLU_012862_9_3_1"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="PhylomeDB" id="B0YD74"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="210"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="470" mass="51304" checksum="38AFDA75DE9BAA32" modified="2008-04-08" version="1">MTRRVTRSAAAREAALFAAKAQDVKPQLTDSNGPDVSPKTGKSTPGRKRKLPIEHPEKLSKSSKTSKPKGSLPSLNVNDDLPHNLGSVSQPLESINVEPKLNKQDPGIEEEEDLDNLASDLQKTVDKATEGLPQQIKISKKKNPYGLTPGATPFPEWARPTPEECEEVNRLLSSAHGEVIPPSKIPEPSLTVTGCGEVPSVLDALIRTLLSGATTGRNSALAFGGLVQRFGILEEGIGKGSVNWDAVRQAPLKDVFEAIKRGGLAEIKSRKIKAILDMVYQENQERKEFLVKGESDGSSDLMPGEKEYEIACADQNFLSLNHLHTLSTEDAMTELVKYPGIGPKTAACVILFCLQRPCFAVDTHIFRICKWLGWVPPGKATEVTAFSHLEVRIPDHLKYSLHQLLIRHGKTCPRCRAITGQSSAGWEDGCVIDHLVTRTGKKKEGNTNVPVASKRRTGRKIRAETDGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDP5</accession>
    <name>B0YDP5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_096310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096310"/>
    <dbReference type="HOGENOM" id="CLU_003433_2_2_1"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="PhylomeDB" id="B0YDP5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="77"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="396" mass="43943" checksum="CB3CF4D501A06EC6" modified="2008-04-08" version="1">MASEFNIAQARTRFPALNAEQVFLDNAATYGISRAATTAFSKGYEAAAKFVNASPDELRLALTPLPQICLGISTTQLLHNLSTALKFEPGDELVLSKLNHEANTAPWVRIAERLGLQVKWWSASDTRNPVCDLDELGQLLSEKTRLVACPHASNITGTITKVKEIAKLVHQYPRALLCVDGVALAPHRQVDVKDLDVDIYAFSWYKVYGPHIAELYASSRIHDQINSLGHFFKGTDTLDLKLNLASASYEATQSIPAVLEFLGPNPAATWDTIASHEEKLQAILLNYLRSQDQITIYGEPSSSKELRVPVISFTVQGIKSQKVVEEVERRTQFCFRHGHMYSHRLLNDVVGLEDVEDGVVRISMLHYNTGESAPGSLRGRVADGHQRKKLPSWSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEK8</accession>
    <name>B0YEK8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_099530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099530"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="PhylomeDB" id="B0YEK8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF29">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="328" mass="36184" checksum="69AA24DA9A800747" modified="2008-04-08" version="1">MSATNKIIVVTGATGIQGSAVAHTFLRLPAWHVRIITRTPSSAAAQALAAAGAEVVRADLSDLDSLRAAFKDATALFLNTDFWGPYRATRDSTAAYDTEILHGRNAAIAAGEVASLHRVVYSTLPGMRELSAGKYTTSYHWDAKAEVVKILEREEGLRGKVSFLVMGAYATNPLILPTVQPGAAGEGRVLRFTIPGTKTMRLPIIAADSLTGEFVRAMVEGPPGTWVLGYDSYLSMEEVVEVWKRVTGWEVEAEEVDLQEMHERFQIPWEVLDAPRFIAEFGYTGSLEVMMPEQLEIRTKSYEEWLAGTNWEETLIKAQEELAGYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF06</accession>
    <name>B0YF06_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_101140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101140"/>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="PhylomeDB" id="B0YF06"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="72"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="369" mass="41779" checksum="3DA01E7DE0D97374" modified="2008-04-08" version="1">MALHSSLPYLDSILPSDLRAKLNSTTTNPWAEPDPTIAAAIPFVNGATGELMAKIPMPSPKRVIRGKLRDLLRTGVEVRFGRRLTDIRVEDDGVIAVFDGEEVRGNVLVGADGAWCEGDSSTRTLPRCRSRTSWSWWVPRHPFSRECAKEERKNAFPSFTREQALFIHGKSHPIVQLAPHPHQKTSIFSNVANVVDPVRPETWVFHYCLSIWTADDAPETAEERRALFKHYMSQYCEPYRSAGEWLSQATPIRAEKFHYWKNITRWRNFGGKVTLAGDAAHPMVPFTAQGLNTALEDVKRFLDAIVKVVYHGADMQTEMDAYDDSAYTRGKRDINLSVEQMHAYHHWEEIMTSPLMKGGYGAFINSSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF67</accession>
    <name>B0YF67_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_101730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101730"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="PhylomeDB" id="B0YF67"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="522" mass="57702" checksum="566595E0D7134C9C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJN7</accession>
    <name>H9CJN7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_m0150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="12"/>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353056.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJN7"/>
    <dbReference type="GeneID" id="11948054"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01665">
        <property type="entry name" value="Cyt_c_Oxidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000082">
        <property type="entry name" value="Cytochrome c oxidase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.80:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="entry name" value="Cytochrome c oxidase, subunit III, four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033945">
        <property type="entry name" value="Cyt_c_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403:SF7">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="Cytochrome c oxidase subunit III-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="11">
        <location>
            <begin position="10"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFE02837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="269" mass="30230" checksum="A40064DB3DD237B6" modified="2013-02-06" version="1">MLYQSKKNFQNHPFHLVSPSPWPLFTSISLFILTTATVLFMHGFQGFSYLVPVAVINVAYVMGLWFRDIISEGTYLGNHTNAVQKGLNLGVGLFIISEVFFFLAIFWAFFHSAISPSIELGAQWPPLGIQGVNPFELPLLNTIILLSSGVTITYAHHSLIQGNRKGALYGTVATIILAIIFTFFQGVEYTVSSFTISDSVYGSCFYFGTGFHGLHVIIGTAFLAVGLWRLAAYHLTDHHHLGYESGILYWHFVDVVWLFLYISVYYWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM11</accession>
    <name>B0XM11_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_001880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM11"/>
    <dbReference type="HOGENOM" id="CLU_046558_0_0_1"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="PhylomeDB" id="B0XM11"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.160.10:FF:000001">
        <property type="entry name" value="Altered inheritance of mitochondria protein 24, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="412" mass="45074" checksum="268BBE1B7F257DE1" modified="2008-04-08" version="1">MSQPLKGGVRALSSIRASPPRVRQGVISLPRRQTRCVQIRAAPSGRPGAVNGDQLAIIDTPSSAESAAFETDARFEVIGAPYSLLSVSLSASQNLYTRRGTLVGLSGKADNVVSTLSILEPFRRAAVGIPFLYQKVSSASPVTALVSVRSPVTSFTVVRLDGSVDWMIAQRRALLAWTGRTLTVRPTINTNLSLAHWGSSEVTGRGLLALVGAGQLYSVELKAGEQYIVHPSNVVAYTMTSNPPRPYRFKSTTLKFQVPGLKSLPNIFQSSKFIRDMADSDTWKTTMNILHKIRTWSRMTIWGDRLFLQFDGPTKILLQTRGPRINDIMSAREINEIADTPRGLTFDPTNPAKQPRVDGEEFKNVAHDAVHAGPGPSRTIEELENEMKGISQSIATLTREGKVIIEKIAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM27</accession>
    <name>B0XM27_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_001650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001650"/>
    <dbReference type="HOGENOM" id="CLU_085418_2_0_1"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="PhylomeDB" id="B0XM27"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="242" mass="25303" checksum="18B43BFB7DD481DC" modified="2008-04-08" version="1">MDPRTSQARPDTHLKPPNPHQRASPSSSTSPSPTPRPPVAAHNTATVAESVTFQGTHPISVGAGTVIHPRARIYSYDGPVIIGEGCIISEKSTIGIPPSTPTSLPPTPKEVVPIRISNGVTIGPLVTVFPGAHIHSFVTVESLAIINRRVSLGAHSKVCSGCEVAANTVIKDWTVVWGSGAGSCQRRKRATGKMSSSVVAGQDLSAPDAKVVEDARLIVLQKEREVVARLIGSSASAGARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMH6</accession>
    <name>B0XMH6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_002760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMH6"/>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="PhylomeDB" id="B0XMH6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="291" mass="31288" checksum="7F5343A0A036AC03" modified="2008-04-08" version="1">MSKIASTFSRLVRFVPRSNPSKILIGEPVDPQVDVGLAVYQGKDVSVRPFTGTSVLNPGQRTNATETIERILSPLSQTEIGSIRCIGLNYVSHAAEMKLTIPNVPTLFLKPSTALADPWPAPTILPKITQVDNTGDYESEMVIVIGRDAKDVSEAEVLDYVLGYTAANDVSSRTSQMNQSQWSFSKGFDTSCPIVSSALIPDASKLHIRGVKNGRVMQDCPLTDLIFSVPQLVSFLSQGTTLPAGTIILTGTPPGVGAAKNPKEFLTAGDEFAVELLPHVGTLITKIEHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMI1</accession>
    <name>B0XMI1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_002810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002810"/>
    <dbReference type="HOGENOM" id="CLU_024456_1_0_1"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="PhylomeDB" id="B0XMI1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.40:FF:000005">
        <property type="entry name" value="CD2 antigen cytoplasmic tail-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="399"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="455" mass="51189" checksum="D32FACF8DD28F924" modified="2008-04-08" version="1">MISSQPRPKRAGEDFTRTHHHDEDDPNGPSEHKKPRFDLRNPSNLAPDALDEDPVLDADEIGRRGQQVRRKAVNLDGYDSDSENEGFSARIEAKAKRTRAKHDAEDDDMFAELQEDFGAEEIDADEALRKNKKTVRFLRDDEIEGQVASSKGGVTLRADLNATGDTVEEDEVESESDVADEDRARLDEGMDEELGAGAKKKHAPLLDAFNMRAEQEEGKFDDQGNYIRKAADPDEIYDSWLEGVSKKDIRRAKEAAEKREAERKERDRLNDSILTADALKTLITHLQRGETALEALARIGKGAPKKPKWQAKKKKNRSKQNGAQVEDAEMTEDDPNEASRKQAIETITGAADILMTRGQTDIYDIEREMLTRQYRQETGEDWVDPPLESAAPTSAEEEPAMWQFRWSDARDGGVEHGPYDSQTMESWKSAGYFGDGVEFRKVGDTGDWTSEATFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0XML6</accession>
    <name>B0XML6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_003180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XML6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003180"/>
    <dbReference type="HOGENOM" id="CLU_1992104_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="125" mass="14174" checksum="51330B91919830F7" modified="2008-04-08" version="1">MKNGTSYELLKLLDRCAALRRQWGKMDPENMMRGSSAGFRRIWTEKPLDSVAEKAPNGQRASMAVKTQASKIACLIHPGMFEADPKSFDCQRAIAKHDTRHLRTFTLRDIGSRQHSDPHLHTSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMX1</accession>
    <name>B0XMX1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_003610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003610"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_1"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="PhylomeDB" id="B0XMX1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="54338" checksum="A8D2F9DBE25135A0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNA6</accession>
    <name>B0XNA6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_004280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004280"/>
    <dbReference type="HOGENOM" id="CLU_058457_0_0_1"/>
    <dbReference type="OrthoDB" id="4492972at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="407" mass="43855" checksum="91273CD5D95C3A3E" modified="2008-04-08" version="1">MSITCSTLLTVPFLALVSLPLVFSAYITICLSILTLFLRLLVLYVELCFAIVSNYFVVPTSSKSSLLSFASEPTTPAASPTPKRRSIDHGVTVILPHTSSHRQIAPFSRVRTRPAPARRRNSSISSTGRPDGDHARPAGKEELRRNGVTTPPSALLTLLSGDEDRDFEGVGGWRCPPSARSQGHVSRSASSSSKASLSDEADERAWLSINDRLELPSQPFPLRSHPETADILPWRHSQAASCSPDGRRQRHHHRSATTSLIPSQTRRAPTSPSASRSNRSAGSGARSRGLSPRPRSQDASSLSTYSDFFHAMASAPQAHSQLHLSNSSEVPGGYFAFRPGNGANSSGSAVSTGTTTPVEDRSSTTSRNMGRFMAHYPAGVRYRRRSVSGANLGSQLPNASLSIDRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNB3</accession>
    <name>B0XNB3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 sterol C-22 desaturase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_004350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNB3"/>
    <dbReference type="SMR" id="B0XNB3"/>
    <dbReference type="HOGENOM" id="CLU_023517_0_0_1"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="PhylomeDB" id="B0XNB3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="521" mass="59042" checksum="61EF2BF23A53A3EE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP16</accession>
    <name>B0XP16_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_005590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005590"/>
    <dbReference type="HOGENOM" id="CLU_010668_0_0_1"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="PhylomeDB" id="B0XP16"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000014">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="269"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="820"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="355"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="999" mass="110702" checksum="5AE8D487E334CC72" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP62</accession>
    <name>B0XP62_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_006060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006060"/>
    <dbReference type="HOGENOM" id="CLU_022947_0_0_1"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="PhylomeDB" id="B0XP62"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="119"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="757" mass="83461" checksum="7A859676FE348977" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPB1</accession>
    <name>B0XPB1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_016710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016710"/>
    <dbReference type="HOGENOM" id="CLU_016472_5_0_1"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="PhylomeDB" id="B0XPB1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="397" mass="44484" checksum="5C5E6892CBA8D00D" modified="2008-04-08" version="1">MDPAPTVSTRKQGRMLAVTGLTEVTFGQKRDPCESFFQKMKTVLVPTDSVSDPQMVNSNVTVFANMPGMLKHGPTGPASSHFKVLTCLTDANQITQANPETLEPIAASTQQELHPDLKGQLYCAHPQFDHRTGDVYNYNLHLGPRSTYRIYHTSAHTSRTEVIATFSIKAAYIHSFFMTEDYIIFCVWPAYFKGLGTSILWERNMLDAMKFDPTAQSHWFVSTSMDTLHRTYYEDLLPPNGEASNFTLRRSETPMTVRYRLPRLPKESTTRTVVTAERVFGFESGELPTINPRFATKRARYHYCIVNRGHTSFFDGIGKVDLETQIIQYWGSDTAPHTSSESIFIPDGTGDAEDAGYLLSVVLNGETGASYLVCLDARTLTEVGRAEHDHAISFGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPB4</accession>
    <name>B0XPB4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein Awh11/Hsp9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_016740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPB4"/>
    <dbReference type="HOGENOM" id="CLU_102617_2_0_1"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="PhylomeDB" id="B0XPB4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="81" mass="8845" checksum="8AA351C56D668549" modified="2008-04-08" version="1">MSDTGRKDFTTKAQEKMTPDSQKSTMDKMKETVTDATDRLTGSAQGDSQKSYSQQAYDSIRGGADNQTHGSSTETMYVPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPM7</accession>
    <name>B0XPM7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_006930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPM7"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="PhylomeDB" id="B0XPM7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="558" mass="62907" checksum="52915FF0E4E1AA71" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ47</accession>
    <name>B0XQ47_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUE domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_008670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ47"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008670"/>
    <dbReference type="HOGENOM" id="CLU_040954_0_0_1"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ47"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="398" mass="44252" checksum="1E1ED806BD85E210" modified="2008-04-08" version="1">MSDEDKMTPSKSAAVPSSPKPESPTTARPLDFDDEPQETGVTTAPPQQTGTEAAPPKPPRPVSPRQQAENTLKEAFPTIEASVIRAVLVASNWDIERAFHALLGMTDPNAQQEDIAPPKPPRPSAAQRQLEADELYARQLAEHYNRRAPQPRWDESRRDRARRGSDQSEEREYSFFDDDLPVIRENIRKGFLETQSKVNSWVQNLKKRLDGEDVDEGPSNQRYGEGQGYSRPRRSGDMGRRSGDRERYDADPQLLSDDFSALELRDSEAPPPQPPRRPLANPNLYKSASPSPDRRKVSFQEGPPSEIGNLYDTSDPAKRTSTGSKSSKWQPLATVEPSPVAENDPFSLGDSEDERDTKGREQNHADEADRIKRATAEAMAGELGTTKVNDQTQTAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQB4</accession>
    <name>B0XQB4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_009360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009360"/>
    <dbReference type="HOGENOM" id="CLU_067596_0_1_1"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="PhylomeDB" id="B0XQB4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="247" mass="27278" checksum="6665354DABD5BD3A" modified="2008-04-08" version="1">MSSGFVAAGTDQEPVERDDEWRRAQQELEEERRRKAELGRQEGGKSLYEVLQQNKMAKQEAFEEKMKLKNQFRALDEDEVEFLDSIMESTRAQEAAVKKETAEQLELFRRQREEAEKALLENSSTDVVPSNDGEDWKIPSRKRRRDKSKEFLIPGKKRKSTSEGAAERSSPSESKAEAPKVQSPSKDGQIPAAVEVPQVAEVTKTTKSLGISSTSATQGAKASLPAAPAAKSSTLSLGLAGYSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQH8</accession>
    <name>B0XQH8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI anchored protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_010010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010010"/>
    <dbReference type="HOGENOM" id="CLU_039184_0_1_1"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="PhylomeDB" id="B0XQH8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF32">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757769" evidence="1">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="357" mass="38878" checksum="0957078B3B673CD6" modified="2008-04-08" version="1">MKCALSLLTLGLAATTQAAYYEYTTATGYFLQDEASTDPSTFDYTANNFGLINRTYATDPDNENTKLTQWQRFYHHIHALNKHAPHKTEYKVFFFGRHGEGWHNAAESLYGTPAWNCYWSLLDGNGTATWSDADLTPAGVAQAQTAHDFWASLITRDGIHTPDAYFVSPLTRALRTANITFGGLALPKDAAAFEPLVMEGLREGISLHTCDHRRSRSYIAGSFPGWAIEEGFSEEDELWNGVTGETRAAQDARSKSALDEMFERTDGKDLFVSVTAHSGEIASLLRVLGHRAFSLKTGAVIPVLVKARKFSNKCAPEPTTVPWTTSAHCTAPPVTSVTACVCASSAAPVTTPLATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQJ7</accession>
    <name>B0XQJ7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_010200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010200"/>
    <dbReference type="HOGENOM" id="CLU_007884_10_0_1"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="PhylomeDB" id="B0XQJ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="395"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="485" mass="51672" checksum="31D33677D7458009" modified="2008-04-08" version="1">MSALRPLQRGANLVSARYISQTARVAANGSNILRRQLPSPLHGRCSAAGIAPRFTAGPSVHSQNAVTRRYASSTASGPVKKTQLYDLHIARGAKMVPFAGYSMPLQYSDLSHVESHHWTREKASVFDVSHMVQHHLSGPGAMELLMKVTPSSLDKLKPNSSTLSCLLEEGTGGIVDDTVITRLDGDAFYFVTNAGRRTEDLAFLQAEIEAYRQTHGADSIKWEILADRALVALQGPLAASVLQPLISSHGAASPADTDLSTLYFGNCRSLHLTLPDGTPTPQPLLISRTGYTGEDGFEISIPTGGCPSLPTQVTELLLSNPEQVRLAGLAARDSLRLEAGMCLYGNDISTAQTPPAAALGWVVGKDRRDPATANFNGAATILPQLASPAKTLSQRRVGFTVEKGSPAREGAIVVDLGDESHPQIGVITSGLPSPSLGGTNIAMGYIKNGMHKKGTEVGVLVRNKVRKATVTGMPWVESKFYRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQM0</accession>
    <name>B0XQM0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain oxidoreductase/dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_010430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQM0"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="B0XQM0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001334">
        <property type="entry name" value="Short chain oxidoreductase/dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="255" mass="27229" checksum="552F385808AE9FEF" modified="2008-04-08" version="1">MSLQGKVAIVTGGARGIGAGIVRSLSKEGAKVSFNYVSASSKAAADALVQELRNENKEALAIQADMTDIDAPSRIVQATLAEFKTEQIDILVNNAGAGDNRPLEEVTVDVYQNLMDVNVRAVIFMTKAILSYIPRNGRIINLSSISARGGYATQSVYAATKAAVEGLTRVWATELGHKYGVTVNAINPGPVNTDMYRAAGPVHLARMEEQNKKVPAGQRCGTVDDIADIVTFLAQERSRWVTGDVICANGGMLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQT0</accession>
    <name>B0XQT0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_011040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011040"/>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="PhylomeDB" id="B0XQT0"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000019">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF39">
        <property type="entry name" value="PROTEIN QUTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="330" mass="36588" checksum="2E14AB5C4220EA92" modified="2008-04-08" version="1">MAIEFTQDTLDEIYAFAVALGRRAGDLLLERIDKQIASDGETAYTYTEKDNAVDIVTQTDEDVETFIKTAIEKRYPEHKFLGEETYAQGQSRSYLIDAHPTWCIDPLDGTVNFTHLFPTFCVSIGFLVNHRPVIGVIYAPAMNQMFSSCVGRGAWLNDTRGARRLPLRRNPIPPMPATSPRGCIFACEWGKDRRDIPGGNMARKVESFVRMASESGGMVHGVRSLGSAALDLAYTAMGAVDIWWEGGCWEWDVAAGIAILREAGGLVTTANPPANPETDPIEEARLGSRLYLAIRPAGPSETETGRQTQERTVREVWKRVRELDYTRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR82</accession>
    <name>B0XR82_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SCF ubiquitin ligase complex subunit CulA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_012440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012440"/>
    <dbReference type="HOGENOM" id="CLU_004747_6_1_1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="PhylomeDB" id="B0XR82"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
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        <property type="entry name" value="Cullin_homology"/>
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        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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    <dbReference type="PANTHER" id="PTHR11932">
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    </dbReference>
    <dbReference type="Pfam" id="PF00888">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="408"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="769" mass="89334" checksum="40234C488421DEEE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRC1</accession>
    <name>B0XRC1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF6 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_012830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012830"/>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="PhylomeDB" id="B0XRC1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031581">
        <property type="entry name" value="Csg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16965">
        <property type="entry name" value="CSG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="441" mass="49720" checksum="ECC558EBD306A8B1" modified="2008-04-08" version="1">MLPNRPTIHRPVDGRPHQPLLQDERRRLSNTDFGHGNAEHRPMLHHSRRPTIRSPEYSAELATRQKYMIASGFLLLSLASFVVQTETAVYIQHELHWDKPYCMLYLTHGSWCLLWPVQLLILRIQKRKLSWEAFWRRHVYLLRTTAQMVESRDLHLTSRDLHRSPIPYMLRTTAFVTVALTIAGGSWYVAVNLTTASDLTAIYNCSAFFAYAFSIPLLNDKLRFDKVFSVVVAIVGVLVVAYGDRSESKQTPDGTVGKTKQDAENRLWGNIIIGVGSVLYGLYEVLYKRYACPPEGTSAGRSMIFANTFGSLIGCFTLLVLWIPLPILHMLGWEEFRVPTGEAAWMLLISVAANATFSGCFLVLISLTSPVLSSVAALLTIFLVAIVDWLRTGQALSAASIVGGLLIIVAFFLLSWSTYREMNEEKRKSLEAEEMESECDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRH4</accession>
    <name>B0XRH4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002480"/>
    <dbReference type="HOGENOM" id="CLU_270729_0_0_1"/>
    <dbReference type="OrthoDB" id="5374844at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134032" checksum="9AAC869F6BE9623A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS78</accession>
    <name>B0XS78_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAR2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_026230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026230"/>
    <dbReference type="HOGENOM" id="CLU_024943_2_0_1"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="PhylomeDB" id="B0XS78"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.550:FF:000003">
        <property type="entry name" value="AAR2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="244"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53107" checksum="0B2335A8B37871B3" modified="2008-04-08" version="1">MPLPLSPSPTILIPHLPAKTLVGIDLVTFTSTPNFHGIRDLPNGWHFLYTGTTESLSLRSGGWFYVGDISVFDESHNGTIVTASSRSLGSDIFVWKWNSETESLELLRASSDADRQEAMRHKANLGAVWQRGGLFRYRSRVSSSRTSQSQSQSQEHQSPVQEDIDEEDEEEGRKDWTDLTNNISPRLLSRIVGDPELDVDGRPRWMVTSGSTAERDSDKIPGLPDINSENLAKVTGEQETAFSFLPVDLKRTWREGAIGRERTEAAQDRSWALGDLIQRHSSGGDRGEQTGEAQILGELQFTFLMVMTLMNYSCLQQWKRLLELVLTCQNAIKDREPFMVSVLRLLLLQLKRCDDVEGGLFDIDGVDGGEFLRKLLMKFRRTLYEVVDNPGPTLKAEFDKLATWVKDEYDWELDREAFVRRGIIQLEDGEEVELEMEDDGDDETGEYAPLVVDLGEGNTTQDPDMANVDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS82</accession>
    <name>B0XS82_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent protease (CrgA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_026270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS82"/>
    <dbReference type="HOGENOM" id="CLU_013989_3_0_1"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="PhylomeDB" id="B0XS82"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="8">
        <location>
            <begin position="307"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="626" mass="70900" checksum="320977C85FE1A3B3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XST2</accession>
    <name>B0XST2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_017510</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XST2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017510"/>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="PhylomeDB" id="B0XST2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="116"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="285"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP53709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="530" mass="58291" checksum="7FF2CB7ED70E6838" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT72</accession>
    <accession>O74687</accession>
    <accession>Q4WIP0</accession>
    <name>GEL1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>1,3-beta-glucanosyltransferase gel1</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Glucan elongating glucanosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">gel1</name>
        <name type="synonym">bgt2</name>
        <name type="ORF">AFUB_018250</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="J. Biol. Chem." volume="275" first="14882" last="14889">
            <title>Glycosylphosphatidylinositol-anchored glucanosyltransferases play an active role in the biosynthesis of the fungal cell wall.</title>
            <authorList>
                <person name="Mouyna I."/>
                <person name="Fontaine T."/>
                <person name="Vai M."/>
                <person name="Monod M."/>
                <person name="Fonzi W.A."/>
                <person name="Diaquin M."/>
                <person name="Popolo L."/>
                <person name="Hartland R.P."/>
                <person name="Latge J.-P."/>
            </authorList>
            <dbReference type="PubMed" id="10809732"/>
            <dbReference type="DOI" id="10.1074/jbc.275.20.14882"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 20-22; 29-47 AND 349-363</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Electrophoresis" volume="22" first="2812" last="2823">
            <title>Proteome analysis of Aspergillus fumigatus identifies glycosylphosphatidylinositol-anchored proteins associated to the cell wall biosynthesis.</title>
            <authorList>
                <person name="Bruneau J.-M."/>
                <person name="Magnin T."/>
                <person name="Tagat E."/>
                <person name="Legrand R."/>
                <person name="Bernard M."/>
                <person name="Diaquin M."/>
                <person name="Fudali C."/>
                <person name="Latge J.-P."/>
            </authorList>
            <dbReference type="PubMed" id="11545413"/>
            <dbReference type="DOI" id="10.1002/1522-2683(200108)22:13&lt;2812::AID-ELPS2812&gt;3.0.CO;2-Q"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 36-38; 78-82; 240-242; 313-316 AND 378-389</scope>
        <scope>GPI-ANCHOR</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1996" name="J. Biol. Chem." volume="271" first="26843" last="26849">
            <title>A novel beta-(1-3)-glucanosyltransferase from the cell wall of Aspergillus fumigatus.</title>
            <authorList>
                <person name="Hartland R.P."/>
                <person name="Fontaine T."/>
                <person name="Debeaupuis J.-P."/>
                <person name="Simenel C."/>
                <person name="Delepierre M."/>
                <person name="Latge J.-P."/>
            </authorList>
            <dbReference type="PubMed" id="8900166"/>
            <dbReference type="DOI" id="10.1074/jbc.271.43.26843"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Biochem. J." volume="347" first="741" last="747">
            <title>Identification of the catalytic residues of the first family of beta(1-3)glucanosyltransferases identified in fungi.</title>
            <authorList>
                <person name="Mouyna I."/>
                <person name="Monod M."/>
                <person name="Fontaine T."/>
                <person name="Henrissat B."/>
                <person name="Lechenne B."/>
                <person name="Latge J.-P."/>
            </authorList>
            <dbReference type="PubMed" id="10769178"/>
            <dbReference type="DOI" id="10.1042/0264-6021:3470741"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLU-160 AND GLU-261</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Glycobiology" volume="13" first="169" last="177">
            <title>Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins.</title>
            <authorList>
                <person name="Fontaine T."/>
                <person name="Magnin T."/>
                <person name="Melhert A."/>
                <person name="Lamont D."/>
                <person name="Latge J.-P."/>
                <person name="Ferguson M.A.J."/>
            </authorList>
            <dbReference type="PubMed" id="12626404"/>
            <dbReference type="DOI" id="10.1093/glycob/cwg004"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>STRUCTURE OF GPI-ANCHOR</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="6">Optimum pH is 5. Active from pH 2.5 to 6.0.</text>
        </phDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Lipid-anchor</topology>
            <topology>GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text>The GPI-like anchor contains a phosphoceramide lipid group. The anchor position has not been determined.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="AF072700">
        <property type="protein sequence ID" value="AAC35942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT72"/>
    <dbReference type="SMR" id="B0XT72"/>
    <dbReference type="GlyCosmos" id="B0XT72">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP53781">
        <property type="protein sequence ID" value="EDP53781"/>
        <property type="gene ID" value="AFUB_018250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018250"/>
    <dbReference type="HOGENOM" id="CLU_021855_1_0_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="PhylomeDB" id="B0XT72"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000343198" description="1,3-beta-glucanosyltransferase gel1">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000343199" description="Removed in mature form" evidence="2">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>(1,3-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <label>1</label>
            <note>donor substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>(1,3-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <label>1</label>
            <note>donor substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>(1,3-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <label>2</label>
            <note>acceptor substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>(1,3-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <label>2</label>
            <note>acceptor substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>(1,3-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <label>2</label>
            <note>acceptor substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>(1,3-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <label>1</label>
            <note>donor substrate</note>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-like-anchor amidated alanine" evidence="2">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="215"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of function." evidence="4">
        <original>E</original>
        <variation>L</variation>
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of function." evidence="4">
        <original>E</original>
        <variation>F</variation>
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC35942." evidence="7" ref="1">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q06135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="10769178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="10809732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="8900166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="452" mass="48121" checksum="75266B9207488269" modified="2008-04-08" version="1" precursor="true">MKASAVTAALAVGASTVLAAPSIKARDDVTPITVKGNAFFKGDERFYIRGVDYQPGGSSDLADPIADADGCKRDIAKFKELGLNTIRVYSVDNSKNHDECMNALADAGIYLVLDVNTPKYSINRAKPKESYNDVYLQYIFATVDAFAGYKNTLAFFSGNEVINDGPSSSAAPYVKAVTRDLRQYIRSRKYREIPVGYSAADIDTNRLQMAQYMNCGSDDERSDFFAFNDYSWCDPSSFKTSGWDQKVKNFTGYGLPLFLSEYGCNTNKRQFQEVSSLYSTDMTGVYSGGLVYEYSQEASNYGLVEISGNNVKELPDFDALKTAFEKTSNPSGDGNYNKTGGANPCPAKDAPNWDVDNDALPAIPEPAKKYMTEGAGKGPGFAGPGSQDRGTQSTATAEPGSGSATGSSSSGTSTSSKGAAAGLTVPSLTMAPVVVGAVTLLSTVFGAGLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTA7</accession>
    <name>B0XTA7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_028760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028760"/>
    <dbReference type="HOGENOM" id="CLU_046570_0_0_1"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="PhylomeDB" id="B0XTA7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000042">
        <property type="entry name" value="Putative exoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="390" mass="41471" checksum="A74DEE6CA331F323" modified="2008-04-08" version="1">MSAQRQASSASQTPHLSPAELSYLYTSLALPDSPIRPDGRSPTQFRPLTAETDILPGTNGSARVGFADGTQAIVGVKAEVEKTALAADALKVSQLSSGDDYTADQGADGKEGMGAAGGHESWVQISIEIPGFRDDDALPVFLSEMMREPLIESVSSAQGGDVEMAGGLKGRLVINRRWHWRLYIDVLLLSQPLSYPLPLLSLTTHLALLSTRLPKLKSKGEEDPFFDDDWNVAEYLYPRQSSGNATTPSPSQFVRPPVTLLVISVADNIIFDPSREEIAVADTVLALSVSRDGETGSLKLISMRTIDPPSRLTQPGVPNSENVTTIGSSAAAEDAAILSPSTGEEEVPGVWKPRRGGVKRSTIARMVKAVLEKGGVGEDVLEGLEGVSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTX8</accession>
    <name>B0XTX8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_019460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019460"/>
    <dbReference type="HOGENOM" id="CLU_049186_0_2_1"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="PhylomeDB" id="B0XTX8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="127"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="360" mass="40021" checksum="BA61725E16DF5A94" modified="2008-04-08" version="1">MPPSTNTLTSPEVKAKLRPKLKEYIVRNREDDTAQFLETCYMFLPPDGQKNLYDDIWACQSNDELHELAETLDTGLIRPLLANANHTPELGSSYSAEEDAIDLIGSDYRKVLERLRKKCLERDANKCVISGSYDQNSDAPDEALTGPLEAVHILPSVLGGPKDERKALSDAWANLYRYFPALRSRLKFTLEDINREHNAIMMLFPLGREFKAFSLILEETSTPNRYRVKTFPHFATAYRGFLPADGLVTLTSQSKRCQPPSPILLAVHAAIGNILHASGRGKAIENVMQEAREDWVCMAGDGSTDVGELLSVTSLALLASSDRARRHQNGQRRGKRRSSPPEADASRKKKGDILGGNDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU49</accession>
    <name>B0XU49_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_030330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030330"/>
    <dbReference type="HOGENOM" id="CLU_031892_1_1_1"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="455" mass="50234" checksum="1B2A1A6064380D32" modified="2008-04-08" version="1">MKNSEILVHISAPSGVRDDVRYRAQVEAILGFQSLSRQLITLSSDERRGNHGALATGQSTSTDPPVDADLGGESKCIQPILSNSQSTIPDEDVEVGRFNAARPNPGHEGLLNATAGSTTLMVKDSMILPDSKVDNSHHISPVSLLSQPQNERAAKDSLESPLSVIPDSQPEAIRSQAEGIMLRPDPCVALGSPPTKRHCSGLSSMLREAVPASDALILAPKLNEEHHRSCELADPHPVTQITPQPDPERPPQVSLDGLPLAIKPSPPPVSREQFVTHVTPTLAMLTRRLKPSRTYKPVKQTRDLEQLERGHWYLRINILQLERDRSLGAPGQQESEARNWDLACFSRFWSFLSDFIAKDGRAGWGVWCILEDATENLCSDSTDGQIMPQRTTAPIISDGKTNPHSFVRPVILKLYAWGEIALHMYLLLFLASERKIRKMGAQWRDGRDEVVIQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUF5</accession>
    <name>B0XUF5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_030710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030710"/>
    <dbReference type="HOGENOM" id="CLU_038589_0_0_1"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="384" mass="41506" checksum="0081235521CB87BB" modified="2008-04-08" version="1">MASPTKRKSPDADHDAFPSDDARTPTDAPPQKKLRITRRQKQALIDNLQLEITERARKLRAQYALQAHDLRSRIERRINRIPVALRKAKMGELLEKHNNSLRMQQTALSPKKHASPGKGTRNLTSASVKRGKQSVSTASPSTRRVKRQSHEGLYSDKENAPAAGDSLDVLKNPKRRANAAGPSRVVSQEVRGADYRILSPKSLNSRTYPQSPFRASPEKPHNSSYLSRPMSPLKPSSPLKSTSASAAGNADNARSRTTKANTTSTRDTRPPSQTKRPASRAATTTKTVRSPLSRPATQLDRRGSISSTASSGTTVMKPGRPGAGTRKATTVSSASAPVKRTTIARNQAPSVASKRSTASATRKATAPAGNEASATGRRVLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUG8</accession>
    <name>B0XUG8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_030840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EDP55023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5377599at2759"/>
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    </dbReference>
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        <property type="entry name" value="DUF7896"/>
    </dbReference>
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        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="492"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP55023.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="695" mass="75831" checksum="AD9754608E68930B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUW0</accession>
    <name>B0XUW0_ASPFC</name>
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            <fullName evidence="6">Cofactor for methionyl-and glutamyl-tRNA synthetases, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">AFUB_031620</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cofactor for methionyl-and glutamyl-tRNA synthetases, putative"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRBD"/>
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    </dbReference>
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    <feature type="domain" description="TRNA-binding" evidence="5">
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            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
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            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="445" mass="47478" checksum="0EEC75681AE68800" modified="2008-04-08" version="1">MAINSAPESSLLSLLYRSYPAAVSPDATELDLLHASPKIFPQTTFSLEEQASIKQWLDTISGLQNALTKDDKSVVMAILGQLNSHLASRTTLLGTKPSVADIAAYALLAPLVEKWTPEERTGEQGYHHIVRHVDFVQNSRLFALQIPDEEKISIDVNDVRFVPKPVDPKEEKERKKREKAAAQNPDAGKPLVVGQGKPEKAATGGTADQAADSAAGVPPKVNKKEKKEKKEKAPKPAPAPAAPPSPSLIDLRVGHILRAINHPNADSLYVSTIDCGDAPGTENTSVDEETGKTVRTVCSGLNGLVPLEEMQNRKIVAVCNLKPVTMRGIKSTAMVLAASPRVAEGEDSHAGPVELVTPPADAPAGTRIGFEGWFDGEPEKVLNPKKKVWETFQPGFTTTDSLEVAFDMSAVPAVQGQEGKPALGKLVAKTGGVCTVKSLKGATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUY3</accession>
    <name>B0XUY3_ASPFC</name>
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        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase III RPC4, putative</fullName>
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        <name evidence="6" type="ORF">AFUB_031850</name>
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    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EDP55123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_024330_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
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        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
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    </feature>
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        </location>
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            <begin position="468"/>
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        </location>
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            <begin position="16"/>
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        </location>
    </feature>
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            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="275"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="358"/>
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        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="608" mass="65193" checksum="512FBB4510DD4130" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV45</accession>
    <name>B0XV45_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_021610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021610"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B0XV45"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF154">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="312" mass="33809" checksum="B78E3FA35AA12EFD" modified="2008-04-08" version="1">MPTNVSFSPDRMPDLSGKVIFVTGGTAGLGAATVLHLAKHTHPPAHIYISGRNAQRADDLIKQVSASNSATRLSFVPCDLASLASVNEAAEAVLRRSSRLDILMCNAGIMAQPPSLTKDGYEVQFGTNHLGHALLIRRCLPLLQRTAEESSDARIVILSSLAFRGHPHGGIVFSDLKTVQHFTACALGPWIRYGQSKLANLLYARELARRYPAITCVSIHPGVVSTGLVENQTRGNRAFIYVTNIGQLMKPEEGAYNQLWAATARKEELVNGGFYEPVGVLGKLHRAAGDDALAEKLWEWTEGALGEYLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVQ4</accession>
    <name>B0XVQ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conidial pigment biosynthesis scytalone dehydratase Arp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_033270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVQ4"/>
    <dbReference type="SMR" id="B0XVQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033270"/>
    <dbReference type="HOGENOM" id="CLU_101889_1_0_1"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="PhylomeDB" id="B0XVQ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000030">
        <property type="entry name" value="Conidial pigment biosynthesis scytalone dehydratase Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="6">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="168" mass="19716" checksum="F40C22CEB6D02695" modified="2008-04-08" version="1">MVEKKPNLTLEFHDYLALKKVLFDWADSYDAKDWDRLRSIIAPTLTVDYRQIGLRKWDDMPAEDYMAMISDMDFLGDPTVKTQHLLGESWWEKISDTEVIGHHQLRAAHQVYTDSTLQTVKLKGHGHATNEHYYRKVDGVWKFAGLKPTVRWNEYQFEDVFRAAKPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWG6</accession>
    <name>B0XWG6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_035850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035850"/>
    <dbReference type="HOGENOM" id="CLU_1677424_0_0_1"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="PhylomeDB" id="B0XWG6"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="3">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="157" mass="17778" checksum="9587430D945F252D" modified="2008-04-08" version="1">MDGCLVEPFGFFCLSHCGCIYIWGCRFAEHIVALLCVQEGVYRYFQLLGVDNCRTKDSPLFKNAEESLLVIRGLGIQTSTSSATYLSKAATRFIPTTQIQDIVIHEAFKGFEVRFYLAVIVEGEPDVVVVFPKLLPRRAILEEVWRGSRRCLYDAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWN4</accession>
    <name>B0XWN4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS hexose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_046720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWN4"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B0XWN4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF66">
        <property type="entry name" value="MFS HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="534" mass="59104" checksum="0B740B8DD6131CBD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWQ4</accession>
    <name>B0XWQ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_046940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046940"/>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="PhylomeDB" id="B0XWQ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF5">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="161"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="421" mass="47036" checksum="9AB249DEDDA2446D" modified="2008-04-08" version="1">MTSTEKQFTVAVVGGGIGGLALAAGLLRRNVPVQIYEAAPKFKEIGLGLTIGPAAHRAMPLIDPQIRHVYDSLITTHADSPGYERFKQTWFEVVWASGPRSGQVLMNLKALPSGQTTVRRADFLDALVGLVPPEIAHFGKRLIRLVESPTGVNLYFEDGTSASADVVVGCDGIHSKVKEFMLPDEYEQTMPRYSGMYGYRAVLDMETMVEAVGDHRARVATMYVGDGAYGISYPIMHAKKVNVGLYVLHDMWDDAAWVRQASRENMARDMKHMGEYVNRLVEWAIFDHPHLSTFARSRIAILGDAAHASTPHQGAGAGQAIEDAHVLAELLGDRRVIEARDVLAAFQAYDEVRRPRSQRVVTSSKENAYLLCLHLHGVEHDEEKLRTTFQERLRWLWDIDIQDQAERARRIMLKKMQNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWX4</accession>
    <name>B0XWX4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide exchange factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_036740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
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                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </dbReference>
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    </dbReference>
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            <end position="384"/>
        </location>
    </feature>
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        <location>
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        </source>
    </evidence>
    <sequence length="1562" mass="172830" checksum="A0659D9BA8821048" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXC6</accession>
    <name>B0XXC6_ASPFC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AFUB_037590</name>
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            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="358" mass="40617" checksum="8A342FF9388F0252" modified="2008-04-08" version="1">MTKSARRSGKGKASASRSASSSGSSTPSSQAGPLPPFSKAPAALRPFLEPLSPQEVYLIHIDTSPPDLKKQTFIVPAIINVVIVAIFALRIYMVRNTYPAMIATVIGLTSSAAVDTSRLSSAETSSLIIRRTFSLMIDYFLITVFLSWPIRFIRGPVQWRRRIGFQGREIIVRRSQRTLSQTLERNRWIRDNDEARDKIVAAITPDRIRKTGYLLVDADWDLDYDAMIKAHEMVDPARKDDRVALSEFRTAVLVNTDADGWLIWRVEDEDTAEARKRSAQSDQILAFKDKLTAMGKEDLFFRWVELIQYESTQPGGFTPERQRSAMLQAKELFERENVDFARFWQEVGGMEGFSDQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXS7</accession>
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        <submittedName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
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                <person name="Wortman J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </reference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="262" mass="27603" checksum="37B6ADB77AA2D431" modified="2008-04-08" version="1">MSDSTSANAPKPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQENKEPTIGAAFLTQKCSLPTRTIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDVTKPSSLTKAKHWVAELQRQASPGIVIALVGNKLDLTSDDGEAAEQPQANDERESSGVEGEDATGDNHEEQEATPGDARKVSTREASEYAEEESLLFFETSAKTGTNVAEVFTAIANAIPESSLKSGRGAGAGTGQTALSAGRPADDTRVNLGDRAAATAKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYC7</accession>
    <name>B0XYC7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AFUB_040440</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYC7"/>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="PhylomeDB" id="B0XYC7"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="20">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="21">
        <location>
            <begin position="143"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP52873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="939" mass="100465" checksum="FB67F1DC28237FAA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYX9</accession>
    <name>B0XYX9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_042460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042460"/>
    <dbReference type="HOGENOM" id="CLU_650690_0_0_1"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="PhylomeDB" id="B0XYX9"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000198">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="364" mass="38945" checksum="1FF53479D95732DA" modified="2008-04-08" version="1">MSSHSSPPLSVRILRFFENIYFFFGLYFGIVTMLGLAGGAVVLALEAAAADPEVVLGLAGLGVLVNGHEYTTAVNSLPVAYLLEERVFGDPIRIHSSSTMTLPTNNAEWGAVISSYKDQLPEVYPVYQTPLPSSVNRYIDHTQLSLDATDEDIDKLCAEAAKHNFSAVCVRLRHVRRAVTNLQGSPECTVACVVGFPEGTHDTMEKEKEALDAAELGASELDMVINWPKLKEGQYMDVYTDVLEVRKGAPSPVKLKVILETSQLTKDEIIAGSVISSMAGADFVKTSTGFKGAGANVDDVAMMRAIVELVGRGTKVKASGGVRSAEDCIKMLKAGADRIGTSSGVNIINQLAGKETQPTTPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ04</accession>
    <name>B0XZ04_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_042710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042710"/>
    <dbReference type="HOGENOM" id="CLU_2426599_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="91" mass="10210" checksum="05E581097CAF7F0A" modified="2008-04-08" version="1">MFYSGGLQEGISLAVTERKAVVCFVRGLSVIPRTITYDATITQSRMLIDGESVDDEENSNIWEEEYFKDDEVNPSMMAIAVVWLLTPMPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ74</accession>
    <name>B0XZ74_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">AFUB_043400</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ74"/>
    <dbReference type="HOGENOM" id="CLU_006515_2_0_1"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ74"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045005">
        <property type="term" value="P:DNA-templated DNA replication maintenance of fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP53170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="782" mass="88202" checksum="9875FFC7168FAA3E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZU6</accession>
    <name>B0XZU6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pathogenesis associated protein Pep2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_034420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034420"/>
    <dbReference type="HOGENOM" id="CLU_067875_0_0_1"/>
    <dbReference type="OrthoDB" id="2533647at2759"/>
    <dbReference type="PhylomeDB" id="B0XZU6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="232" mass="26691" checksum="3864BA61D0FE5A0F" modified="2008-04-08" version="1">MPDLHSLPEGTRPSRAIRNNGPDNLVLERARLRELAEGWPCYRDACEWENFASIFHADAYVYTTWSGRMHYADFIAASQAGMDKGAFIMHRCHGVTSDITPDALRAVTKMKATITQRFTIDGCEVDAEADCRFCFFFEKVDGRWAARLVRHWYEKDRLIPVIPGRFPKLDEEKLNGYPEGYKCLAYCQELTMGVAVLRDMPGHRRHSGVCGEKHDRLYRLAKDWLDGKDIEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-10-14" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y004</accession>
    <name>PHIA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell wall protein phiA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Major allergen phiA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phialide development protein A</fullName>
        </alternativeName>
        <allergenName>Asp f 34</allergenName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phiA</name>
        <name evidence="7" type="ORF">AFUB_045170</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Cell wall protein involved in development of asexual structures such as phialide and conidium development, and thus required for spore formation (By similarity). Plays a role as a general stress protectant produced by the fungus in competition with antagonistic bacteria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="allergen">
        <text evidence="6">May cause an allergic reaction in human.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phiA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y004"/>
    <dbReference type="Allergome" id="3672">
        <property type="allergen name" value="Asp f 34"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="B0Y004">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP53342">
        <property type="protein sequence ID" value="EDP53342"/>
        <property type="gene ID" value="AFUB_045170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045170"/>
    <dbReference type="HOGENOM" id="CLU_097238_0_0_1"/>
    <dbReference type="OrthoDB" id="4093325at2759"/>
    <dbReference type="PhylomeDB" id="B0Y004"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052820">
        <property type="entry name" value="PhiA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0020">Allergen</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000434418" description="Cell wall protein phiA" evidence="4">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A2R2S8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="D4AV66"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q5ATP7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53342.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="19380" checksum="FC7B2F8BED541C8C" modified="2008-04-08" version="1" precursor="true">MQIKSFVLAASAAATASAAACQAPTNKYFGIVAIHSGSAVQYQPFSAAKSSIFAGLNSQNASCDRPDEKSATFYIQDGSLYLYAASATPQEIFVDRSGMGQGKIGYTTGAQPAPRNSERQGWAIDSQNHLQFQGKDLIACPNSIDGAWSIWADAGVANPAGNTDCVGIAARVEDVTNPNSCVYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y052</accession>
    <name>B0Y052_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_045650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y052"/>
    <dbReference type="HOGENOM" id="CLU_1156139_0_0_1"/>
    <dbReference type="OrthoDB" id="4225164at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="240" mass="27069" checksum="C4E0246857C65973" modified="2008-04-08" version="1">MKTAPQPASIHDVDEDDNILLHSKRSATRVMKGMSPSSSPPRSHSRVNSNSRTSQKCIFGKSICRGPIENMVKECGLNRDCPLTIFTRSQDQSRERNEVPGYRFRKVFFTDETEILNPDAIYDRGRYVRLTAFIAEKEETHPDPRIYVEQRVYQGNQEMIMIHELIFGGMIQVGIEYVFTACGDEDVQLGKRDLRLTIKSSRTLTPGFSYSRMSSTATCIAQSITAMIAKTLCSSASTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y086</accession>
    <name>B0Y086_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_035140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y086"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035140"/>
    <dbReference type="HOGENOM" id="CLU_038084_0_0_1"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="586" mass="65243" checksum="113937855DCD0F42" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0C1</accession>
    <name>B0Y0C1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_035480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0C1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035480"/>
    <dbReference type="HOGENOM" id="CLU_049768_5_0_1"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0C1"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="11">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP52385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="98" mass="10888" checksum="864FC2EEC9B356AF" modified="2008-04-08" version="1">MGYVPDGRVLGLSKLARIAEVYSRRLQVQERLTQEIADAINRVLAPTGVVVLIESTHLCMSMRGVQKSGATTITSCMTGVLEHDPKLRNHAEFLLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0H5</accession>
    <name>B0Y0H5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_046210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0H5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046210"/>
    <dbReference type="HOGENOM" id="CLU_979943_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0H5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="154"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="284" mass="31926" checksum="72CF2DE38884B58E" modified="2008-04-08" version="1">MAWAEEQLAQASSATCENRTETTLSGAANFITTASHNERRHEPIYCEPEVRVPGPATISGGYERKRAALREKLFRMLPEQNVRKLNLEANRDPFTSSVFIQLPPKFQLQSMFEVAFTEANHVLPLFDVSVLRDLVEQHYSDPTVPPGKQPGRWAMLNAAIAVAIQLRTARGSYSEMTELSWHFFKNSFSMYSVIALRAADVLGLEALLAMAICTQGSSDVRTTSVLVCAAARLSLAFGLHRREFYSALDHAAADRHKRAFWIAYILDKSISRRQGCPLYLRTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0J8</accession>
    <name>B0Y0J8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_046470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0J8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046470"/>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0J8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="507" mass="55262" checksum="977549E94EF1341B" modified="2008-04-08" version="1">MSDEKQQQNDAREAIAKETQASQNVSPKDFSVFTTNEKRAIILMGSLAGFFSPLSSSIYFPALDTIASSLQVSITKINLTVTTYLLLQGASPMLIAGFSDKVGRRPAYIICFTIYIAANIGLSLQNSYAALMVLRCIQSAGSSGTVALSNGLVGDMITSAERGSYIAVASIGLMLGPSLSPIIGGLISQYLDWHWIFWFLLILSSVFFAILLLFLPETCRKVVGDGSVPPPPLNNNVSDIIRHRRRKRAGLAADQASIAEYRKNYRFQLPNPLPTLLIAFELETGLILLAAGLVFAGFYAVMTGASTSFHEIYGFNDIQSSLMYIPIGAGGIVASFVTGPLVDWNFRRHARRAGLPVEKRKQSDLSNFNVERARLEVALPAFYICCVTMIAYGWVMNQKVNLAGPVILLFLFSLGLSCTSQVLNALLVDLWPKRSAAATAANNLFRCELGAGASAAIAPMTNAMGHGWAYTTLALICVLSTGCLWWTMFFGIQCRQKRAQREQARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y118</accession>
    <name>B0Y118_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_059290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y118"/>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="PhylomeDB" id="B0Y118"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905754">
        <property type="term" value="C:ascospore-type prospore nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="847"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="905" mass="100604" checksum="A7B32A16C6977E7A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y193</accession>
    <name>B0Y193_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_049120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y193"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049120"/>
    <dbReference type="HOGENOM" id="CLU_834163_0_0_1"/>
    <dbReference type="OrthoDB" id="5403091at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="340" mass="38248" checksum="7EE22A6E9E4D6180" modified="2008-04-08" version="1">MHDLLRDSPSSPPRDRPSGFAACDPADRADLEEAARAGDFDLLRSVAHNRAWIVGQSYCRSRDSIDSCERYLHSLWYVYYQCARHVSHESFEQDRWILDILRTRGRGPLTRPAPGAGIDIARTPDGTVWNDLPLLATDMTGFWINDCAAMSSKQRLNAASFLAKLASTRVANDRLCQIALILFRETFEAVRPLGSSNEPEDEDPRRPIHVLTIASLLPSTCAWIREAGHNIILLSDVLWNDCSNSTIGKGGFTFVQSELGQRAPDGFSPWRWLYWLKRLHQIADEASKADEKILAEQAAKAIDIMLSHVKQRNSKILRVFEAAGDAVTQDKDFLGLTKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1A0</accession>
    <name>B0Y1A0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_049190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1A0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049190"/>
    <dbReference type="HOGENOM" id="CLU_060131_4_0_1"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1A0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF5">
        <property type="entry name" value="HYPOTHETICAL ACETYLTRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="248" mass="29061" checksum="27C9AE800D62EBAB" modified="2008-04-08" version="1">MQPQFRVEVVSDDDFPELYRALWEAFENPYQGIVRLFFPIHNDDREGSLKACVKSQLEEYHKEQPHVTWIKVVDTEANKIAAAAKWYFYPENPFAKKEGPIVADWFPEGVTREWATQAVRQFEHPRESMARRPHAFLHIAFALPEYRGKGLSHLFMRWGVEKADTLGLEAWLDASEFGAPVYKKYGFREVLTNSVKPIPTRKLSDEEQIEWTRCEEIFLPIDERVMWRPVLGQYVEGETPLARLDETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1C3</accession>
    <name>B0Y1C3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein (Pet191), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_059740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059740"/>
    <dbReference type="HOGENOM" id="CLU_037393_1_0_1"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1C3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="68"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="295"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="408" mass="45923" checksum="3882C21B11D21212" modified="2008-04-08" version="1">MMDQKMSSSGPPISEAHMKAPSIQFPDGTVQQSTILRPIHPSPAFRNGHVNLDTFSPVNENGSFEFDRVLKTGQVHRRVKHKHAFRASWKPAYLVLRPNLLSVYKDEEATRLRASITLSEVTAVAPVKSPRSSRQHVFGIFSPSKNYRFQALSEKDAEDWIRRIRAETRADEEEEAFLALSRNRNVPATNRQHIEDTTDHSEFEYPGRASSPELGRSLSPGRYSTRYGSLQDHSGNEITSYSEWSDGPTSNSSTHMKPNRSLQNLSTSAPVGGQQLQPRDVGRSQELGILRDPERVICNGYLQCLRIKGAVRQWKRLWVVLRPKSLGFYKDEQEYSAIKILPMSQVIEAAEVDPLSRSKKFCLQIIAEDKSYRLCAPDEESLANWLGSLKSILVARKKLEPAPGASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1S8</accession>
    <name>B0Y1S8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Snf1 protein kinase complex subunit Snf4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_060710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1S8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060710"/>
    <dbReference type="HOGENOM" id="CLU_021740_1_0_1"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1S8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000217">
        <property type="term" value="P:regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="348"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="408" mass="45395" checksum="85D22A42EDAB5A6E" modified="2008-04-08" version="1">MAEHASQWTMQRPPTGRNNLPPEPTTATAMANDTPTPTAAHATISASTTTTTTTTTTTTNTFPLSTPDLTIAHGHEGPFVQPSSYLRPRGLSHPMRSSEPERAIDREEREGLRAIRNFLKVRTSYDVLPLSFRLIIFDTSLSVKETPLWDSKTSTFAGLLTTSDYINVIQYYFQNPAALDQIDQFRLDSLREVEKALGVAPPETISIDPERPLYEACRRMLESRARRIPLVTNDSQTDRPHVLSVVTQYRILKFVAVNVSDTQKLKKPLKEILLGTYDNIATASMDTPVIDVIHILVERSISSVPILNSEGVVYNVFEAVDVITLIKGGVYDDLSLTVGEALKKRSAEFPGIYTCSLNDGLDTIFDTIRKSRVHRLVVVDGDFRLKGVLTLSDILQYILLEGENDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1U7</accession>
    <name>B0Y1U7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_060900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241013_0_0_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1U7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1V9</accession>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y220</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">AFUB_050620</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y220"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050620"/>
    <dbReference type="HOGENOM" id="CLU_096980_0_0_1"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="PhylomeDB" id="B0Y220"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="144" mass="16321" checksum="6AC26D0220929F9C" modified="2008-04-08" version="1">MSWFQKTFTLPPRSRGSYLITDEVLSQLPEIRNYKVGMLNLFVQHTSCALSLNENWDEDVRADMSDALDRIVPTDRKGNLYRHSAEGEDDMPAHIKSALVGASVNIPITNGRLATGTWQGIWYLEFRTSRHTRKVVATIQGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2E7</accession>
    <name>B0Y2E7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_051190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2E7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051190"/>
    <dbReference type="HOGENOM" id="CLU_075842_0_0_1"/>
    <dbReference type="OrthoDB" id="4496773at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="318" mass="34347" checksum="5A58A78F2DEDA1B8" modified="2008-04-08" version="1">MHSQTTKDEQSKDDSSNEKQDAIERRRLQNRLSQRNHRRKIRDRIAKLQERVIASELRAVATLNGWDQASPPAASMMESKPQGDFDSNPLASVSEDPAISNPPQRNVSSNLCRSCCSLLNQMPSSSSLPSPTSPLPFDLGLTNGVDSTNSSPSTLLNSSPSSSQLSPFSLDTSLSMTGLQSQNEFSFPPYPDPPGSQQYPHCPQYYVATEASLPHIMQRLGSATSHPKAIILIPHGHGYAPAPFTGANAADSTGLRSALNGNLNLQNPGCHCLRPDRSAKSSDLGTSGDWMNAPSSTPFCPLHPSQSSSLDNYQSMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2X0</accession>
    <name>B0Y2X0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial export translocase Oxa1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_052150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2X0"/>
    <dbReference type="HOGENOM" id="CLU_029282_5_0_1"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2X0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="13">
        <location>
            <begin position="80"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="436" mass="48682" checksum="D123B66CF6242152" modified="2008-04-08" version="1">MSARFNSTSSVTDAAASEHLSGAPTDTGVPDLSDLSAADLSSIPEHIGYLKDLGLDYGWGPSSIIQFFIEHIHIWGGLPWWASVVGTGILLRLALLYPTLGAVDTSTKMLNIKPVTEPLRQQMIMRGKEGNQIEMLKLRAEIQKLHQEQGIVAWKSFIPMLQIPFGFGCYRVVKGMAALPVPGLTLESVAWLKDLTVADPYFILPAASALFMYLSIRKGGENGVNQLQGTALGRLLMFGLPALSFLFMAFFPSALQLYFVTTGLFGLGQAYLLSSDTFRKSMNIALPVRQPKNGQSPGRDDSQQSKSIRILREHLEAERAKMIQEQHKSPNSLEISFIDRALNNLKEAKENIKRETAEKLDAVRGQAPVKNADGTIAEPPRLGEKDLKLAADYERRRKEEEDWKREERNHARREAHLKAMELEREKARSAFKVKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y385</accession>
    <name>B0Y385_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_053300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y385"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="B0Y385"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000922">
        <property type="entry name" value="Protein kinase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000786">
        <property type="entry name" value="Protein kinase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="54"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="415" mass="47151" checksum="FBABEFFD56EF5FF2" modified="2008-04-08" version="1">MNLRRIIQSIPCKPPPIPAKLLPPADLVEEEHTPHYKSQHFYPVRLYEILDNRYQIAAKIGWGTSSTVWLARDLHQWRWLPPRYVAIKVNAHNYASQESAEKELRITEHITKANPQHPGRNFVATLLDSFRVASPSGTHICMVFDALCEPLWMLKHRFEGNTIPLDVLKPVSKLILEGLRYLHTECHVIHTDEQDLKSDNILLALRNPSILDSVAQDEMNNPSPRKQLDDRDIYLSRNYWGLSPAELGRSVITDFGLAVRGDGAPNSHPIQPEEYRAPEVCLGADWSYSADIWNLGVMIWDLFYGRGPFDTPPNARGSGSADEAHLGQIISLLGPPPPDLLSRGKDTSRYFDAKGQFKFPELIGKKDLVSMAKEIEDDDGMPQFVDFISRMLRWRPEDRTTAEDLLSHAWLLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3I7</accession>
    <name>B0Y3I7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_054340</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054340"/>
    <dbReference type="HOGENOM" id="CLU_035901_1_0_1"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3I7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF4">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="20">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP51428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="453" mass="49367" checksum="D007FD7575B0A4B9" modified="2008-04-08" version="1">MFARVFKAMPARASALTSVNASIPARFMATVRQQRPAHERATFTIRDGPIFHGKSFGARTNISGEAVFTTSLVGYPESLTDPSYRGQILVFTQPLIGNYGVPSAERDEHGLLKYFESPNLQAAGVVVADVAEQYSHWTAVESLGEWCAREGVPAISGVDTRAIVTYLRERGSSLARITVGEEYDADQDEAFTDPEQIHLVRQVSTKAPFHVSAADPQCHVAVIDCGVKENILRSLVSRGASITVFPFDYPIHKVAHHFDGVFISNGPGDPTHCQETTYHLRRLMETSQVPIFGICLGHQLLALAAGARTIKLKYGNRAHNIPALDLSTGRCHITSQNHGYAVDASTLPSDWKPYFVNLNDSSNEGMIHKSRPIFSTQFHPEAKGGPLDSSYLFDIYIDSVKKYKASQAAFYPQRDSLPSPLLVDLLAKERVGVQPTIGMQNIAAAATAAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y482</accession>
    <name>B0Y482_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_056840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y482"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056840"/>
    <dbReference type="HOGENOM" id="CLU_009020_1_1_1"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="PhylomeDB" id="B0Y482"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090518">
        <property type="term" value="P:L-arginine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090515">
        <property type="term" value="P:L-glutamate transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090513">
        <property type="term" value="P:L-histidine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090517">
        <property type="term" value="P:L-lysine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090516">
        <property type="term" value="P:L-serine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090514">
        <property type="term" value="P:L-tyrosine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="37"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP51673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="513" mass="55618" checksum="7E816D4576B4F4F6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5I7</accession>
    <name>B0Y5I7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_063540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063540"/>
    <dbReference type="HOGENOM" id="CLU_008471_0_0_1"/>
    <dbReference type="OrthoDB" id="5297881at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5I7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="786"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
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        <location>
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            <end position="720"/>
        </location>
    </feature>
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            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="799" mass="87905" checksum="58C515B9D12DAA5D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y638</accession>
    <name>B0Y638_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_065550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y638"/>
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    <dbReference type="HOGENOM" id="CLU_052989_3_0_1"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="PhylomeDB" id="B0Y638"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
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        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22727" checksum="5A77DBA1CE450F41" modified="2008-04-08" version="1">MKLLPNSTNYIFRVDFDTLEVSSAGEVLSNATVVELTSLDGSQLVNGATTLNEDAILVSDSSNGWVYKVDVRTGAYDVIVDDPLMKKNSGAEGKAGVNGIKVFGGYLYWTNTDAGLLARIKINDDGKPCGVSEIVASNLTEADDFTLDENGTAYIALGPLENEVRVVRPGGSNRLAAVDGPTAARFGRQHGDHHRLYFSTHGGRSSVPSFKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y676</accession>
    <name>B0Y676_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Telomere length regulator protein (Rif1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_065930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002628_0_0_1"/>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="PhylomeDB" id="B0Y676"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="135"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1182"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1340"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1581"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1192"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1417"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1466"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1581"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1605"/>
            <end position="1617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1703" mass="188191" checksum="6F582EEC5D4ADB81" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Y5</accession>
    <name>B0Y6Y5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_068570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068570"/>
    <dbReference type="HOGENOM" id="CLU_909047_0_0_1"/>
    <dbReference type="OrthoDB" id="4201669at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="306" mass="35075" checksum="FEB57249218715C9" modified="2008-04-08" version="1">MDFFPKIITSIVLPTLKIYISLSDGSSGQAKYSSSFENSIRSKSERSRYGVLETHPYPDSINNSLPTWSVYLRTHYSPPPPPPELQRSRCQSKIYGAQIENWKTKLAKFKGILNELGAEYRNLRNENLRLKDSKATLENERNEIESGIKDAKRQISQAAVLVKEKRTQLAESERKVESMTLALKNEEEKTAFVQTQLVEERRRSSILESYIHNNSRVQTKQLAIIRTEQQEMLNKLNSAFXXXXXXXPPPPVPPYWTCSLVLHRHLSPVVESRLLPDREDPNKLARYPVRRTVQGRGGRQAARPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y757</accession>
    <name>B0Y757_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Geranylgeranyl transferase beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_072640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y757"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072640"/>
    <dbReference type="HOGENOM" id="CLU_028946_2_0_1"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="PhylomeDB" id="B0Y757"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000032">
        <property type="entry name" value="Putative geranylgeranyl transferase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="6"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="416" mass="46397" checksum="DA890F1260B7BA5E" modified="2008-04-08" version="1">MTETVFNKERHIKYYLRCLKTFLPHQYTSNDSNRMLLAFFTISGLDILGALDSKITAEERKGFIDWLYHCQVPSGGFRGFTGTDFGIDKRTPENEAWDPANVPATFFALVVLLILGDDLSRVKRVECLQWLPKLQREDGSFGEVLGPGGEIKGGRDLRFCCCAAGTRYILQGRSGSGLEGVSDINVDRLVEFIQACQTYDGGMSEAPFRESHSGLTYCAIGALTFLCRLPKDQRHMALLSPGSQEFEHLLKWLVSRQTSELGEEESDEEVDGSPDQSDSLHRDTSNLALNDKIAVLPNLAPPTEESLLWAGFNGRCNKYADTCYSLWNSGTLVMMDRLSLIDQQRNRRYLLEKTQHIIGGFGKGIGEPPDLLHSFAGLVSLAFQGEEGLSSVDPALCASHRAARHMESLPWWQETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7B1</accession>
    <name>B0Y7B1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="9">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="9">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="9">PHB:PPT</shortName>
            <shortName evidence="9">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_073190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="9"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7B1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073190"/>
    <dbReference type="HOGENOM" id="CLU_034879_2_0_1"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7B1"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF39">
        <property type="entry name" value="POLYPRENYL TRANSFERASE AUSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="339" mass="37306" checksum="241A8E09F1AA1079" modified="2008-04-08" version="1">MGPKLVLTNAISEYNPLPCSKYSTPKTGVFSIMPRRWIPYAELMRLDRPAGYWAFYWHFVIGLTLAANMSSPIPSPLTLVSLFLFFAVWVIILRGAVCTWNDTLDQDFDRKVSRTRNRPIPRGAVTTIQGHLFTLAQIALGTAMLLPLPLGCMYRAALMTAILLVYPLGKRVTDFPQVILGIAFGMSIFVCSAALDADPHPLLGTETDDLRLVTALCFYIASILWTAIFDTIYAHQDAKDDAKVGVRSLAVRLGDRTKHTLSVLAATQVMLLFAAGIACNFSAIYFAGSCIGTAISLAALLWFVDLRHSASCAWWFCRGSHLVGASMVAWLLGEYCVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7R2</accession>
    <name>B0Y7R2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-dehydroshikimate dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_074700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7R2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074700"/>
    <dbReference type="HOGENOM" id="CLU_035063_0_2_1"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7R2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="37"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="353" mass="39813" checksum="60511FE2D112399A" modified="2008-04-08" version="1">MIAPAPTITYESLRNIPLSYATCSIGSSNADTLPRKLEAISKAGFTGIELSFPDIIDYGSRILDHQVASENFAEIISVAGEIRKLCDANNLKVMMLQPFANFEGWPRGSLERQDAFTRVNGWIEIMKVVGTDLLQVGSSDTPAEKITTDRNQIVSDLRELADLLAKCNMRLAYENWCWSTHAPTWKDVWEIVKAVDRPNIGLCLDTFQTAGSEWGDPRTISGRIDDMDVDELNRRFAASMDELARSIPPEKIYLLQISDAYKPTRPIEDKVINGLRPRGRWSHDFRPMPYDGGYLPIEEVARAVLKTGFRGWFSMEIFDGGNQGKGKKYDMIPYAKNAMESMQRLLKNCSDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y855</accession>
    <name>B0Y855_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_076160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y855"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076160"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="PhylomeDB" id="B0Y855"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="28"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="343" mass="37459" checksum="0D6280943669A362" modified="2008-04-08" version="1">MSRIKFAILDDYQNLSRKHFAHLTSRVDISYFPDTLDPRVPAQQQQLIARLQPFDAILAMRERTPFNAATIAALPNLKLLLTTGNRNLSLDLPALTARGIPVAGTVGRPPGVNSTVQHTWALILALARHVARDDAAVKAGKWQGSLGVNLSGKTLALLGLGKLGAQVGRIAVLAFGMRVIAWSANLTQEKADEQATAQGLPAGSFEAVPEKREFLQRADVLSVHYVLSERSRGILGAEDLAALRPDAMIVNTSRGPLIDERALLETLNAGRIRGAALDVFDPEPLPVDSPWRTTAWGVDGRSEVLLTPHMGYGEEELINGWYKEAAENLERWLDGKELHVRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y856</accession>
    <name>B0Y856_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_076170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y856"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="PhylomeDB" id="B0Y856"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="230"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="422" mass="45462" checksum="DCB7F2DB5CE267A1" modified="2008-04-08" version="1">MDGGKDAWLFLAACFMIEALIWGKFQHLTQSGASSRPNSCPGFSFAYGIFQDYYSTHEPFQGSSNIAIIGTCTMGVNYLLAPVNFGILLAFPRLRVWAAPAGFVTMSLALALSSLSTTTTELIISQGVFYGLGASVAYTPTIIFMDEWFARRKGLAFGIMWAGTGLAGVVLPVVLQWLLNTYGYRVTLRAWAVILFVLAAPLLYFVKPRVPISASSSMRTFNLSFVLDRTFLIYQAGNIIEALGYFLPTIYLPTYARSLGANNLTASLTVILLNLASVFGCIMMGSLVDRCHATTCILISTVGTVLATFLLWGFAVSLAPLFIFCVAYGIFAGSFTSTWPAILGEVRKKNPYADPGIVFGFLCSGRGIGNVLSGPLSEALMAGEKWSAGYGYGSGYGGLIVFTGVTALFGGLSVFERPLKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y893</accession>
    <name>B0Y893_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ORC6 first cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_076540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y893"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076540"/>
    <dbReference type="HOGENOM" id="CLU_045412_0_0_1"/>
    <dbReference type="OrthoDB" id="5367324at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="441" mass="48866" checksum="E2A6DC99F9192649" modified="2008-04-08" version="1">MNNRPVEQALSTLLPTHANDLPPELVSLALSLVAQSRSFAASLKPEEEIARPYACAEIACRRTLKLPPLLGHPPCPPRAYKKLYSFLERSLSSSVSPSKHARDSLAQGTPSRSGSAPSTPTKTQALVKATATPRRLQNTTSKSTPLKLAANASDRAAAPSPTPQKTSKLRPNGLSGSTIIPDAPAWVMDSIRIVCKTLSTPAPRTSTWSRPPISRTLPPHIFAGVSSILYLISNLSAKNDEDLDEEMMEFLEPIITVKDTEKDEDFKELVYALIVAVYFIVLARRRNAPDDGSSEAGEARKMDKKTFSEMRQTALVSLGLPSTERRHRDDVDQWIALIMEQGWTNGQDWFENIPRAGEVDGDDEYLSDEYDGRDNKRKRQKTSGAGHGFLLENSSKRKGLLPGLGTMIQDRVDWLSADRREDYIEWKADVMARIQQMTSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8A7</accession>
    <name>B0Y8A7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_076680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076680"/>
    <dbReference type="HOGENOM" id="CLU_1447336_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="187" mass="20626" checksum="AD4BA1FEE02AE701" modified="2008-04-08" version="1">MQRENTHRPFDGSRSSSSITSRTEAAANLPTAAASLSSNPPTNPSKTPISSAPFSRDISLRALRIASSSTFFIVPDTFITRNTHDRIFPAPAGAPFFIPPLLKSGTCDIYVRAVQTRRNDARGHRMIAVEVAGDKYLTIHSCQNPKQIKKQHMMKRTTNTPGPNTTQPADAPVPENLRDFLPHHLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8B4</accession>
    <name>B0Y8B4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_076750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8B4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076750"/>
    <dbReference type="HOGENOM" id="CLU_328709_0_0_1"/>
    <dbReference type="OrthoDB" id="3647246at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055528">
        <property type="entry name" value="DUF7102"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057559">
        <property type="entry name" value="SAM_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23394">
        <property type="entry name" value="DUF7102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23395">
        <property type="entry name" value="SAM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7102" evidence="2">
        <location>
            <begin position="547"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-like" evidence="3">
        <location>
            <begin position="768"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="874" mass="96941" checksum="A6401B3F8564572D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8H2</accession>
    <name>B0Y8H2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">AFUB_077330</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0Y8H2"/>
    <dbReference type="HOGENOM" id="CLU_000513_2_0_1"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8H2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000036">
        <property type="entry name" value="Aspartate carbamoyltransferase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="28">
        <location>
            <begin position="607"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="28">
        <location>
            <begin position="1142"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="29">
        <location>
            <begin position="1399"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1864"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1889"/>
            <end position="1930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EDP49703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2253" mass="247975" checksum="B65C7B09C0B29694" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8I6</accession>
    <name>B0Y8I6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonsense-mediated mRNA decay protein Upf3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_077470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077470"/>
    <dbReference type="HOGENOM" id="CLU_018549_1_0_1"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8I6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000637">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein Upf3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000797">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein Upf3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="424"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="577" mass="60469" checksum="5F6C7FA8BCE852EF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8J6</accession>
    <name>B0Y8J6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_077570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8J6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077570"/>
    <dbReference type="HOGENOM" id="CLU_1948348_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="129" mass="14319" checksum="740B716AED2093DE" modified="2008-04-08" version="1">MSPIKGFRIKSARVYRSGDLRVYHKLFRLASSSPDESPLSLSRNQKPAAQALLSSRLEAHSTHELTASTASPTAESKWKWQVAMSITSHPYVWHCPEQTSKNGLRGGENPKCCYLPSAHGEVTKNFLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8T5</accession>
    <name>B0Y8T5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NGG1 interacting factor Nif3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_078490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8T5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078490"/>
    <dbReference type="HOGENOM" id="CLU_037423_0_1_1"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8T5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000008">
        <property type="entry name" value="NGG1 interacting factor Nif3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="392" mass="41978" checksum="09116F6F3BDFA218" modified="2008-04-08" version="1">MTESVTDGFGRLSPLLSLGVYLAVRQLSTMSTTSSPFTRAVVSSMRKLYPESLADKSFDNTGLLLEAPFHPARRQKNSVLLTIDLTKAVADEAIKRKDSVVVAYHPIIFRGLKSLTLNDTQQQTLLRLASEGISVYSPHTAVDATPGGMGDWLCDVVTGAIAPSTDSSPPLSASTSQQYSQPTYPQPRPASITPSSAAPHVRSTIHPSPPPVPEGMESAGMGRLVTFETPQPLTTIVDRIAQGVGHPGGIPIAIPQTVPVDLIKIRTIGICPGSGSSILMSSGSLPDLLFTGELSHHEALSAVERGSVVIALAHSNTERGYLHAVMRQKLAATLKEEWEAQREEGLKALEETFKQGGASVIGSYEEVYKDPSCAVDVSERDRDPYGIMIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8T8</accession>
    <name>B0Y8T8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_078520</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SKN7 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8T8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078520"/>
    <dbReference type="HOGENOM" id="CLU_008776_2_1_1"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8T8"/>
    <dbReference type="PHI-base" id="PHI:123473"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000380">
        <property type="entry name" value="Transcription factor SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="16">
        <location>
            <begin position="366"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="574"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP49819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="622" mass="68668" checksum="D8733BDC62345879" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y937</accession>
    <name>B0Y937_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_079520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="58478" checksum="D0991F5109B232D0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA97</accession>
    <name>B0YA97_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_083890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA97"/>
    <dbReference type="HOGENOM" id="CLU_008871_0_1_1"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="PhylomeDB" id="B0YA97"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000260">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000021">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002431">
        <property type="entry name" value="Repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="4">
        <location>
            <begin position="472"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="3">
        <location>
            <begin position="614"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="804" mass="89714" checksum="CB8470B306A1FFD3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAC4</accession>
    <name>B0YAC4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_084170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084170"/>
    <dbReference type="HOGENOM" id="CLU_060351_0_0_1"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="259" mass="28702" checksum="EAC6C028139A1172" modified="2008-04-08" version="1">MTANQTSSSSSSSSSLSTRISLRWPPDPAFENTDTIVLSLMGWYVDLRVDKSTGKIDWAIAGQRIVESQEPLRVLFTHAIDSHNAFEAVDCGTFTQLPNGDDLETGSMPRWDLPGKPVREYEEVWRELAFREGPGRGVSWVLEARGDVQGVSGQDASTVTRMFIARIWGTYVALRQEQMHSGGDSEAEIKDGGEVSARREEWDSTSGWKTKYVLGPDADKLPSMTTIGTGDGDWSIGSEVLLSDQPYIVRACERIDQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAT2</accession>
    <name>B0YAT2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_085740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085740"/>
    <dbReference type="HOGENOM" id="CLU_085156_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760912" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33670" checksum="A1A695F671705572" modified="2008-04-08" version="1">MPSFLLLLLAIGVVPVWSFSLDTPTKYWNYTTASLSSTTSPECKAAYSAHIDCDDFLLALAVSKEDRWWLQDFDSAVFDRTCTATCQSSLSAYVANVEQTCNKARDAACKTNGPENLGDPVLVPVVTLGHILQYVLMRSCAKDDDGSYCYIGQSNLYYDNGECDWTCALAYFWVCHEYPYDNYQFGIHLPGMEGQRTELIPSSVLLDDSQNSTYGWATVEQCGWTTNDTLPLYNPGMSRRVVEEQSTTNTLAASTATSTATSTATSTATSTATSTATTTVTADSGTGSIRMHLDTGMAVWILAFGIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB97</accession>
    <name>B0YB97_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_092040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092040"/>
    <dbReference type="HOGENOM" id="CLU_1489390_0_0_1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="225" mass="26561" checksum="230518019D55A47B" modified="2008-04-08" version="1">MGFCLNINSLSSSPWLLFLLIDSLDIHHKHTGCIMTSKKWKKEWWSQPDNRADQHIKIKYGWSEDWGYWIKVMDDRLEMADDWHSRYNTLAELDRFRASVLDGGREGCYLSVYTGPRGRGKRVDFEVMMDLWELYKVANSHILSEFRNLSKREIDEVSDTVEAKIIDEWVNPWARKCECQDCEAFDALVAANNKKNESDENDNDEEEDEDEDEDEDEDEDEDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBP6</accession>
    <name>B0YBP6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_087380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087380"/>
    <dbReference type="HOGENOM" id="CLU_1916591_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="132" mass="14131" checksum="5DD3A5D1884B3530" modified="2008-04-08" version="1">MALKNAQRVTFSNMISQNLMSFACTTSPIPVTVRIMIIAPPVPITSATPVVVPMVWVTAMVFRRALAPVPIPVMAARVIIPTDPSNILATAISSSVIWVAASSISSVALYCLRCWVPRQEKQLPGQAAAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCF0</accession>
    <name>B0YCF0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_089960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089960"/>
    <dbReference type="HOGENOM" id="CLU_009352_0_0_1"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="449"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="828"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="865"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="951" mass="110177" checksum="C5C130D8A90EADD9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCH9</accession>
    <name>B0YCH9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NF-X1 finger transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_090250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090250"/>
    <dbReference type="HOGENOM" id="CLU_005714_2_1_1"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="PhylomeDB" id="B0YCH9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06006">
        <property type="entry name" value="R3H_unknown_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000006">
        <property type="entry name" value="NF-X1 finger transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034077">
        <property type="entry name" value="R3H_FAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="880"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1085"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1102"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP48310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1145" mass="123461" checksum="ED0FBEB4D87B36AE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCN0</accession>
    <name>B0YCN0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS alpha-glucoside transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_090770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090770"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B0YCN0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP48361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="546" mass="61358" checksum="0070468E0AAB9992" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCP3</accession>
    <name>B0YCP3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_090900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090900"/>
    <dbReference type="HOGENOM" id="CLU_027543_4_0_1"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="PhylomeDB" id="B0YCP3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="66"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP48374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="349" mass="39075" checksum="8327C42ABDC3B73D" modified="2008-04-08" version="1">MGSSNDFHDDETLELLKHYLNLSSNLTDLYTQWSSQDPNFKKKAPQFTGIRILRQDAWEALVSFICSSNNNITRISQMVEKLCVNYGPLVATVGDRAYHDFPPPEALTADDVEGRLRSLGFGYRAKYIHQTALIVAKEREQGWLDSLRNPESPVLGVQPVPGDEMRPEGRQGYRHAHEQLLGLQGVGPKVADCVCLMGLGWGEAVPVDTHVWQIAQRDYKFGRGAHKSLTKATYDAVGNHFRKLWGKEAGWAHSVLFTADLRAFSDRLAGASGKIDVKVAVREEGEDKESVKVETEVTTSTAYALKRPATEKLLESKDMKEESKGNEKAVIQASQTTTTRRMSKRLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCP6</accession>
    <name>B0YCP6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_090940</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCP6"/>
    <dbReference type="SMR" id="B0YCP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090940"/>
    <dbReference type="HOGENOM" id="CLU_017374_3_0_1"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="PhylomeDB" id="B0YCP6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000310">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="378"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="485"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="573" mass="64102" checksum="20D99AF1B561BCBD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD06</accession>
    <name>B0YD06_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-1,2-mannosyltransferase (Mnn2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_093840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093840"/>
    <dbReference type="HOGENOM" id="CLU_013298_0_1_1"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="PhylomeDB" id="B0YD06"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000177">
        <property type="entry name" value="MNN5p Alpha-1,2-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF5">
        <property type="entry name" value="(MNN2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="493" mass="56491" checksum="F9B257268F439355" modified="2008-04-08" version="1">MSVPRIYSRLRTLLLALFLVSVFTWSFSRWRSVSVEPGHKNPSYVDSAGVRVLHSADGHIHFWQQFQPLLAKYQPKCDPPMRLGNAPSVRFEEAKPEDRREYLDMLPDEVEAMKNAHTGFVRDIKSNPPQLHYVPNTRGLVSTAGGSYLPVLVISLRMLRKTGSELPVEVFLANEEEYEEYICDVVLPSLNSRCVVLSHILDAVPKTMQIEKYQFKLFAMMFSSFEEILFLDADAFPLEKPDILFTNEPFRSKNMVTWPDFWADTISSYYYDIASKPMPSKTIRQSTESGELLLSKKTHSKTLLLSAYYNFWGPDYYWALLSQGAAGEGDKETFVAAALTMDEPYYQVSEPIVALGHRTQSGLAGSAMAQFDPVEDYALTQKGEWRVHGSKAPAPRAFFIHANFPKFNPATVFDEQAVKPTFEDDGSYTRAWTIPEEVIGKFRTDVEKQFWREILWTACELETKFRSWEGREGICQRVKDYWNAMFPTQSVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD18</accession>
    <name>B0YD18_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_093960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093960"/>
    <dbReference type="HOGENOM" id="CLU_001832_0_4_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="B0YD18"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000038">
        <property type="entry name" value="DEAH-box RNA helicase (Dhr1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="381"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="581"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="915"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="917"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1211" mass="134707" checksum="DCCCE57E13B5D713" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD97</accession>
    <name>B0YD97_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin containing polyamine oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_094780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD97"/>
    <dbReference type="HOGENOM" id="CLU_004498_6_0_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="PhylomeDB" id="B0YD97"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="535" mass="60161" checksum="BCA8610220CA8C2B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDF5</accession>
    <name>B0YDF5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetylglutamate kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_095390</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095390"/>
    <dbReference type="HOGENOM" id="CLU_006384_4_0_1"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="PhylomeDB" id="B0YDF5"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000154">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003387">
        <property type="entry name" value="PRK04531.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="20">
        <location>
            <begin position="355"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP47689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="906" mass="99446" checksum="5E26A372F49363E1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEH0</accession>
    <name>B0YEH0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_099150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099150"/>
    <dbReference type="HOGENOM" id="CLU_070147_0_0_1"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="PhylomeDB" id="B0YEH0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="260" mass="28246" checksum="B33DA36C48CA395A" modified="2008-04-08" version="1">MSTRRGVGLGAFANRTQTSQSYANHGANLRSAHLESLQTQLSVFQSLLHTFALEHGSTIKSNPTFRAEFARMCNAIGVDPLAASNVKGKNGRRGESASFWTQIMGGDMNDFYFEVAVRVVELCRSTRSDNGGLLGVEECRKKVGKGKAIGSGLEVTDDDVLRAVKSLGPLGSGFSIVQVGSKQYIRSIPKELNTDQATVLEAIQILGYVSLSMLQLNLNWTKARAQTVIDDLVADGLVWVDTQGEENEYWSPQNLLDDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEJ8</accession>
    <name>B0YEJ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphate:H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_099430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEJ8"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:selenite:proton symporter activity"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097080">
        <property type="term" value="P:plasma membrane selenite transport"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Phos_permease"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="566" mass="61684" checksum="5C5B39FE53D694BA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEW6</accession>
    <name>B0YEW6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_100740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP47079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF3">
        <property type="entry name" value="ATROCHRYSONE CARBOXYL ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="315" mass="35346" checksum="73235EAF8EB23588" modified="2008-04-08" version="1">MDQYSNLFAFEDYLGAQARSIPDLPEVDVLSPRVVRVLGGNPGQMQLQGTNTYILGTGAERLLIDSGQGRARWEQLMASLAAEHKFRISTVLLTHWHLDHTGGVPHLFRIFPELRGANAIYKYHPDPSQQAIVDGQVFSVEGATVRAVFTPGHSTDHMCFLLQEEEAIFTGDTVLGHGTTGVEDLEEYMQSLRKIQSLGCRIGYPGHGAVIENMQQKVQQEIDRKQRRERQVLLALQNIQREKRTVGDANGAATQAELIEAIFGRLPADVADRFFAPYMKDILMKMARDKQVGFRFKGGQKHWFANVSQENPVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XLY7</accession>
    <name>B0XLY7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipid transfer protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_001490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XLY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001490"/>
    <dbReference type="HOGENOM" id="CLU_105945_0_2_1"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="PhylomeDB" id="B0XLY7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="155" mass="16455" checksum="D44EB27029165833" modified="2008-04-08" version="1">MSLKNGTSFPYSPTNRPEATSPTDKRLMETTDAFPSSAAFDVINSALQSDEAERKDAIKNAKAIVAFNLKNASGQEESWYLDLKDKGVVGKGAAPAGGKADVTLSLSDADFASLVSGKANAQRLFMGGKLKIKGNIMKATKMEPVLKKAQSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM34</accession>
    <name>B0XM34_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Toxin biosynthesis protein Tri7-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_000750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000750"/>
    <dbReference type="HOGENOM" id="CLU_032731_0_1_1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="PhylomeDB" id="B0XM34"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF27">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="245"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="429" mass="48260" checksum="34B2DE9F0C5E23FD" modified="2008-04-08" version="1">MDLVPSSTLWSIAQELALYLAFTVPTAFVIITTPKSSFLRLAWTPCLLYILYRFSLQVPSLTTSQFLNGVAAGQATVAALQCLNLLLITKLDERELVHAGLCIPSSSLLVRVACAWALLVNFRGIGTVWEVKNVPQHAAYLQKPKQHRLSRRRYVLRESAIIIWQYLLLDLIHMSTKDTPPGDLARLFGPGLEYRYLDATAEQWFGRVSVGIFSWLVPSRVCLNIVSRIYCLVLVVLRISAPESCRPSFGRVRDACTIRGFWGKFWHQSFRWPLTSVGSFVARDVLRLPRPSLLERYTNIFFTFFTSAVLHLACDAILGIPPSGSGAMPFFCVVPLAIMFEDGVQEVWRRVTGPSQGAVPFWQRLVGFLWVGSWMCATSPWYLYPAARQPPERTWMVPVSVVGEIGLRVAQKVLLVYGVVLYWAIGGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM63</accession>
    <name>B0XM63_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_001030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001030"/>
    <dbReference type="HOGENOM" id="CLU_511868_0_0_1"/>
    <dbReference type="OrthoDB" id="5429716at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760322" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="56359" checksum="EE6758DDA5BE0FB6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMI9</accession>
    <name>B0XMI9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_002890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMI9"/>
    <dbReference type="HOGENOM" id="CLU_004133_0_0_1"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="PhylomeDB" id="B0XMI9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="624"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="645"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="681"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="717"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="754"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="790"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="826"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="862"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="898"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="958"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="968"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1062" mass="116999" checksum="472D26C5BA59EAB5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMJ7</accession>
    <name>B0XMJ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I specific transcription initiation factor RRN3 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_002970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002970"/>
    <dbReference type="HOGENOM" id="CLU_010579_1_1_1"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="PhylomeDB" id="B0XMJ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="712" mass="79104" checksum="D7C505BC601DBE95" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XML9</accession>
    <name>B0XML9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_003210</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XML9"/>
    <dbReference type="SMR" id="B0XML9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003210"/>
    <dbReference type="HOGENOM" id="CLU_017172_0_0_1"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="PhylomeDB" id="B0XML9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000344">
        <property type="entry name" value="Nuclear protein localization protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="16">
        <location>
            <begin position="265"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="601"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP55624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="652" mass="73087" checksum="AF77E57AFAD80B23" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMS7</accession>
    <name>B0XMS7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_014020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014020"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B0XMS7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000088">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="43"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="446" mass="49187" checksum="C76754A87173C8CF" modified="2008-04-08" version="1">MGVIPPEEPIDLFRGWPNPALLPTSALAQASATVLSTPSIRTPALLYGPDDGYLPLRKSVAEWLTHFYKPRDPVGFDRICITGGASQNLACIFQVFTDPSYTRHVWMVAPAYHLASRMVDDAGFAGRVRAVPQDDAGLDLDYLRREMEAAERKANEEQRFEPKHKPPRPWGKIYKHLIYATPTFSNPTTRTMSLSDREQLVQLAREFDALIVTDDVYDFLQWSVDPDCPLAAPDEARVPRLVDIDRYMDGGPQDEWGNVISNGSFSKLIGPGMRTGWAEGTAKLAYGLSQTGSSRSGGAPSQIASTIIAQLLINGTFQSHLTGVLQPAYARRYHVMMSSIRKHLLPLGVGLPDSSEVVGGYFIWVRLPSPLRAADIVQLAQKTQNLRVAAGEIFQIPGDSVDRGNDFHDFLRLCFAWSEEDQLAEGVRRLGCVIHDALVGPAANST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMW3</accession>
    <name>B0XMW3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_003520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003520"/>
    <dbReference type="HOGENOM" id="CLU_169255_2_0_1"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="PhylomeDB" id="B0XMW3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="65" mass="7587" checksum="EDBA85F3BF40B711" modified="2008-04-08" version="1">MAKSKNASQHHRSQKAHRNGIKKPKTHRYPSLKGVDPKFRRNHRHALHGTMKALKERKEGKREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMX4</accession>
    <name>B0XMX4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MYB family conidiophore development protein FlbD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_003630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003630"/>
    <dbReference type="HOGENOM" id="CLU_046302_1_0_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="B0XMX4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901002">
        <property type="term" value="P:positive regulation of response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902584">
        <property type="term" value="P:positive regulation of response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902806">
        <property type="term" value="P:regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000037">
        <property type="term" value="P:regulation of stomatal complex patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000355">
        <property type="entry name" value="Transcription factor MYB124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="314" mass="35514" checksum="1736D863553F888C" modified="2008-04-08" version="1">MAPTHRRGPWVPEEDQLLLQLVREQGPNNWVRISQHMHYRSPKQCRERFHQNLKPSLNREPISTEEGLMIERMVNEMGKRWAEIARRLGNRSDNAVKNWWNGSMNRKRRGLSATTTSPSRTFQGRVEAPYPRASTALGSPIDRPRFSLSHNRPLTSWTNSSIQTRRESSAASVDCPRQLSPIYTLPALNRPVETPLTSPSFSDVSPPSMVSDHNSVSSASPRTVASPQMLPLPVDLRRPSHASEDGYVSHHAYSSLKTVEPFSDVASKPRWVPDQQPWSHPTASSTPTWAPPEPCRSEQQPQRDARMGLDNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XND3</accession>
    <name>B0XND3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_004540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XND3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004540"/>
    <dbReference type="HOGENOM" id="CLU_002173_2_4_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="PhylomeDB" id="B0XND3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000015">
        <property type="entry name" value="IQ and HECT domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="849"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1225" mass="139610" checksum="6DE783D08441852E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNF1</accession>
    <name>B0XNF1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_004720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_018631_0_0_1"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="F-box_dom"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="603" mass="67623" checksum="9ECD31649FEF7F6B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNG1</accession>
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        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">AFUB_015030</name>
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    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015030"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="PhylomeDB" id="B0XNG1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="223"/>
        </location>
    </feature>
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        <location>
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            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="27"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="602" mass="66110" checksum="6E44220998E4010C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNG6</accession>
    <name>B0XNG6_ASPFC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_015080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
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    </dbReference>
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    <dbReference type="OrthoDB" id="4364812at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="302" mass="33929" checksum="5059EBD4911B8510" modified="2008-04-08" version="1">MPLQILDGEPPSPPAWGTLPLDIYLLSEWDTPNSSYLAKASQHPVPESPSDRRSRLIRQFLALGSPYQSQTETPPTPTNSQITEILRPARPESLRPYAEYTGSLDEGLYLRLCYDADKEEVHRFLWSQNLDVAFVGPDGIIFDDKELFGGGGINLARFLETFPERVTNAGSVAHAKHRETVLRDTLMRIREGGGNTEAEEEDGFPEEVKDPLLQYGEYHAACVVTHLFIEDEEALDGNGLLHVFFDDTGNVVRHWRTDDEGGDYDFDGTWKEGNWKEDFVSGRGELGVVYREGGVRGPPYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPA8</accession>
    <name>B0XPA8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_016680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016680"/>
    <dbReference type="HOGENOM" id="CLU_046299_0_0_1"/>
    <dbReference type="OrthoDB" id="5295627at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049232">
        <property type="entry name" value="DUF6829"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20717">
        <property type="entry name" value="DUF6829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="468" mass="51274" checksum="214B905C73680959" modified="2008-04-08" version="1">MLRRFKAFVLSTLRFLWCPESPSHPQMAALRDVIARGEFPTLSNTEAIHLFASSFPTELSHLRNASATVESGSSTPPGCLEGKTPSAVIYGADFAEVNRTLVSMLALKWTLADDYESFTRGQSEGKLTLETFKRMREVIIRNLHDPGDIYALLVAILIDDIGKDSALATTAEAEAEANHSELVYHAAQGDRIPALAGVPNRGREAIMRSLQIGSKLNLSQLVQGECAPASLSVLRSIDKGGCGFEMRAIVTLLDVAGAGAHRDARGCALMTESVCRAYLRTIEVVGEFIRGNIPTERACYDRILTDRAELLHKKGFALLSVENAEERTLLRLLCMGRGDSLESAEMFQAAFQILPEPTRRRLVDGLSVAGIGDGVAIVPYYAPGLLAEVLRSVYHKERSSIVAALSAFLRFLARVFDGPRPNTDGIQERDLSFVQDVIKSDRFGDDPSILDTVRLPWIDLSDTIDPRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-04-22" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPE7</accession>
    <name>BTAF1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TATA-binding protein-associated factor mot1</fullName>
            <shortName evidence="1">TBP-associated factor mot1</shortName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mot1</name>
        <name type="ORF">AFUB_006220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="427" last="427">
            <title>The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Furukawa T."/>
                <person name="van Rhijn N."/>
                <person name="Fraczek M."/>
                <person name="Gsaller F."/>
                <person name="Davies E."/>
                <person name="Carr P."/>
                <person name="Gago S."/>
                <person name="Fortune-Grant R."/>
                <person name="Rahman S."/>
                <person name="Gilsenan J.M."/>
                <person name="Houlder E."/>
                <person name="Kowalski C.H."/>
                <person name="Raj S."/>
                <person name="Paul S."/>
                <person name="Cook P."/>
                <person name="Parker J.E."/>
                <person name="Kelly S."/>
                <person name="Cramer R.A."/>
                <person name="Latge J.P."/>
                <person name="Moye-Rowley S."/>
                <person name="Bignell E."/>
                <person name="Bowyer P."/>
                <person name="Bromley M.J."/>
            </authorList>
            <dbReference type="PubMed" id="31969561"/>
            <dbReference type="DOI" id="10.1038/s41467-019-14191-1"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH NCTA AND NCTB</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity (By similarity). Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B (PubMed:31969561). The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter (PubMed:31969561).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPE7"/>
    <dbReference type="SMR" id="B0XPE7"/>
    <dbReference type="EnsemblFungi" id="EDP55920">
        <property type="protein sequence ID" value="EDP55920"/>
        <property type="gene ID" value="AFUB_006220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006220"/>
    <dbReference type="HOGENOM" id="CLU_000315_1_0_1"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="PhylomeDB" id="B0XPE7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045898">
        <property type="term" value="P:regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000449617" description="TATA-binding protein-associated factor mot1">
        <location>
            <begin position="1"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 2" evidence="2">
        <location>
            <begin position="473"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 3" evidence="2">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 4" evidence="2">
        <location>
            <begin position="957"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 5" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 6" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 7" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="1316"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 8" evidence="2">
        <location>
            <begin position="1526"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1663"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box" evidence="3">
        <location>
            <begin position="1440"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1329"/>
            <end position="1336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="31969561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="31969561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="31969561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1891" mass="210209" checksum="B00CF4FF708709F1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPY1</accession>
    <name>B0XPY1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc knuckle domain protein (Byr3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_007960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007960"/>
    <dbReference type="HOGENOM" id="CLU_058879_2_0_1"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="PhylomeDB" id="B0XPY1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000023">
        <property type="entry name" value="Cellular nucleic acid-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000084">
        <property type="entry name" value="Zinc knuckle domain protein (Byr3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000076">
        <property type="entry name" value="Zinc knuckle domain protein (Byr3), putative (AFU_orthologue AFUA_1G07630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="190" mass="19873" checksum="F475B5D93845B44F" modified="2008-04-08" version="1">MEYQAGGRGCFNFAFNVSKEVAGGDASHQARDCPKKGTPTCYNCGATIGQGHVSRECTVAPKEKSCYRCGVAGHISRECSQAGSGDNYNGAPSGGQECYKCGQVGHIARNCSQGGNYGGGFGHGGYGGRQQTCYSCGGFGHMARDCTHGQKCYNCGDVGHVSRDCPTEAKGERVCYKCKQPGHVQAACPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPY6</accession>
    <name>B0XPY6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretion related GTPase SrgD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_008010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPY6"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="B0XPY6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001537">
        <property type="entry name" value="Secretion related GTPase SrgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="242" mass="26336" checksum="33BDB3D2BE5BCEEE" modified="2008-04-08" version="1">MSQPWDYIAKLVCIGDSGTGKSSLTIRLCEGRFSSSHDVTIGVEFGSRIVPVGPPASKSLGVDSDKKMKLSLWDTAGQETYKSITRSYFRGASGALLVFDITRPSTFTSCTQWLQDLRQIAEDGIVVILVGNKSDLAEVKSDVNQRRVTRQEAEEWCRMNNVVRYVETSAKSGEGVERAFLEVAERIYRNIEAGKYDLNDRRSGVKGFGATGGASASTPKTITLGLNDAMRSGGNGWRGACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ13</accession>
    <name>B0XQ13_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1680 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_008330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ13"/>
    <dbReference type="HOGENOM" id="CLU_013148_3_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049049">
        <property type="entry name" value="Beta-AFase-like_GH127_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20737">
        <property type="entry name" value="Glyco_hydro127C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="23"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="2">
        <location>
            <begin position="454"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 C-terminal" evidence="3">
        <location>
            <begin position="566"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="75745" checksum="4C5CAA2F15A751EE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ75</accession>
    <name>B0XQ75_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AHC1-like C2H2 zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_008980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008980"/>
    <dbReference type="HOGENOM" id="CLU_016272_0_0_1"/>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ75"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="312"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="724" mass="76330" checksum="80DE751775CC5593" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ78</accession>
    <name>B0XQ78_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein transport protein (LST8), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_009010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009010"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ78"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000923">
        <property type="entry name" value="Protein transport protein (LST8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="415" mass="45283" checksum="1AFB3C3312A372D9" modified="2008-04-08" version="1">MKATTEQRPGASLTPSSCSLCVQRLVPLFLFWEALSGICSRTIQHPDSQVNRLCITPDKRYLAAAGHNNVKLYDIKSTNPNPVMTFDGHTNNITGVAFHCEGKWMVTSSEDGTVKVWDTRTGSLQRNYAHKSPVNDVVIHPNQGELISGDRAGIVRVWDLGESVCTHQLIPEEDVAVQSVSVASDGSLLCAGNKKGNVYIWRMIQDAELTRIVPICTFQAHKDYLTRVLLSPDVKHLATCSADHTAKVWNLDPDFPPAKMAAITAAKARATGNESPAPEAKEPVATDPVASPTSPKVQDLHVGADLGRSGELNPITYIRGNAPANPEPQQTFPVQPDGPPMDMATGTPFLETTLANHQRWVWDCAFSADSAYLVTVSSDHYARLWELASGQIIRQYSGHHRGAVCVALNDYSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQD2</accession>
    <name>B0XQD2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_009540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009540"/>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
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        <property type="reaction ID" value="UER00076"/>
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    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Adenosylhomocysteinase"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP56246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="446" mass="48490" checksum="380D4856297E026F" modified="2008-04-08" version="1">MAAPAQKFKVADISLAAFGRREIELAEIEMPGLMAIRRKYAEDQPLKGARIAGCLHMTIQTAVLIETLTALGAEVTWTSCNIFSTQDHAAAAIAASGVPVFAWKGETEEEYQWCLEQQLNAFKDGQKLNLILDDGGDLTALVHSKYPEMLKGCYGVSEETTTGVHHLYRMLKEGKLLVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCADALRSMGARVLVTEIDPINALQAAVQGYQVVTMEEAAPQGQIFVTTTGCRDILVGKHFEVMRNDAIVCNIGHFDIEIDVAWLKANAKSVQNIKPQVDRYLMPNGRHIILLAEGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKAEDEAFGKKYVEFGTTGKKPVGVYVLPKILDEQVALLHLEHVNAKLSKLTPVQAEYLGLDIAGPFKSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQE0</accession>
    <name>B0XQE0_ASPFC</name>
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        <recommendedName>
            <fullName evidence="5">Pre-mRNA splicing factor Clf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_009620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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            </authorList>
            <dbReference type="PubMed" id="18404212"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="373"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="77789" checksum="6C0FB7EAE31408DB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQT6</accession>
    <name>B0XQT6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_011100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011100"/>
    <dbReference type="HOGENOM" id="CLU_009650_0_0_1"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="PhylomeDB" id="B0XQT6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="92529" checksum="01A1F3C4859AB577" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR71</accession>
    <name>B0XR71_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF718 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_012330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR71"/>
    <dbReference type="HOGENOM" id="CLU_100689_1_0_1"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="PhylomeDB" id="B0XR71"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="127" mass="14850" checksum="DC09EF7EF87E4550" modified="2008-04-08" version="1">MAPVRRIAQIVHLKPSAVEAYKECHANVWPEVLQQIKECNIRDYSIFFDNERTLFATFKYVGDDYEADMEKMRANPKVREWWAMTDGMQMWTMLMCSYLQESPIPGAVGSAEGPGWWKVLDEVFYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRH3</accession>
    <name>B0XRH3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_002470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRH3"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="PhylomeDB" id="B0XRH3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="290" mass="31651" checksum="A6C5CE9EBDAEC325" modified="2008-04-08" version="1">MDLLQREGQYPLPPQAPETMGVEFSGTIENLGPDANRDFKVGDEVFGLAYGGAYAQYIAVSTNMLIHKPAELSWEEAAGIPETWITATQALYLVGEYKPGQSVLWHAGASSVSIAGIQLAKADGAKAIYVTAGSDEKIDFCVKKLGATAGFNYHTQDWSAEIQKATNGEGVNIIVDFIGATYFQGNLDAAAKDGRIVNLAVMGGVKLPEGVNIAPFLRKRLRFEGSTLRSRDEQYQKKLRNTLVEHALPKFKDGSFKVFVEKVFPMEQIIDAHKLMESNQTKGKIICTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRI5</accession>
    <name>B0XRI5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosome biogenesis protein Brx1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_002590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRI5"/>
    <dbReference type="HOGENOM" id="CLU_048373_2_1_1"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="PhylomeDB" id="B0XRI5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000465">
        <property type="term" value="P:exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="84"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="376" mass="41918" checksum="6677078D4B91CB3A" modified="2008-04-08" version="1">MAAVYKTVTKKKPRQIAEDQDEVDVEMEDLLAGADDTSDSDEDEDEHTAESAKKQLAAGFMPKTRVLMLTSRGVTYRYVEGFRELGLTFQTLTSDSSHRHLLSDLCALLPHTHKESKLDTKKKTAGYNLLLNSLADLHSCNVIFFLEARKRGQDLYLWLARPPNGPTIKFHVTNLHTMGELNTGFSGNCLKGGRGIVVFDRSFDEQGPVMSSPGNEYRGLIREMLRGVFCVPKRGVKGMKPFIDRVIGVFGVDGKIWIRVYEIRESEGGAKKDEENSKPAPKGKNAEPEISLVEIGPRFVLTPIVILEGSFGGPVIYENKEYVSPNQVRSEIRLSKAARYAKRRDVQTNLISKRSTLGLAEGERKPGPLDNKSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRT9</accession>
    <name>B0XRT9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Voltage-gated chloride channel (ClcA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_024810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024810"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="PhylomeDB" id="B0XRT9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="911" mass="99954" checksum="06C88A6A5966B4AF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS58</accession>
    <name>B0XS58_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable NAD(P)H-dependent D-xylose reductase xyl1</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_026020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS58"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="B0XS58"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="313" mass="34883" checksum="933800C402BF9E6C" modified="2008-04-08" version="1">MAVYETRFKLNTGAEIPALGLGTWQSKPGEVERAVSHAISVGYRHIDTAYCYQNETEVGNGIKEALQSGKVKREDLFVTTKLWCTYHTRVEEALDKSLKNLGLDYVDLYLMHWPLAMNPEGNHELFPKHPDGSRDIVHSHSHITTWKSMEKLLATGKTKAIGVSNYSKRYLEQLLPEATVVPAVNQIENHPSLPQQEIVDFCKEKGIHITAYSPLGSTGSPLFTAEPIVAVAKKRGVSPASVLLSWHIARGSSVLAKSVTPSRIEENRTSLIKLDDEDMATIAKYTNELAEKKAFQRFVYPPFGVDFGFPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS61</accession>
    <name>B0XS61_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_026060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS61"/>
    <dbReference type="HOGENOM" id="CLU_879915_0_0_1"/>
    <dbReference type="OrthoDB" id="4509321at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="316" mass="35650" checksum="152FA4D5689F41DF" modified="2008-04-08" version="1">MDSPRPRNWNQKLFATYLGGTDKEIHELRRVLTQLMSAHGKLDKGYKSKAARTELQEWIQSNLHRLPGFVQDACFNRTRMDGLMGMAYKIKNEHVHYLAARGRPNHAAEPPSSTFDQGSGVVHGSQRVEREDNRDVFDQPISSLPSNAVEQQVNAIEVAGPVADVQEETIAEPPSKRARTTLVQTAPLQPPLPDLLSRNIWVLNEVNPAKHGLCSMQDLLTTPESRKIDFVPRLIDLDFDHWLSIVEAQCDYDFTAHRLEYRPPANVVSRSLGLPPITIPLSTQSQWRGAINSQIHAESGRDPVFYLVSQCEYDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSF7</accession>
    <name>B0XSF7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_027030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027030"/>
    <dbReference type="HOGENOM" id="CLU_000488_0_0_1"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="PhylomeDB" id="B0XSF7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758293" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2035"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2059"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2093"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2125"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2171"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2216"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2253"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2295"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2325"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2352"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2398"/>
            <end position="2418"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="65"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1701"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1953"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1765"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1963"/>
            <end position="1973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2426" mass="272500" checksum="4051E96F478BAFCB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTU4</accession>
    <name>B0XTU4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_029960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTU4"/>
    <dbReference type="HOGENOM" id="CLU_094650_0_0_1"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="PhylomeDB" id="B0XTU4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19067" checksum="B97369573CA71753" modified="2008-04-08" version="1">MDYWGMPVVRTNLTPYIFGINIQHCQAAIPGDGNDVICMTYTYDMAAFLIRLLDVADWPEFSIMVGDEVTYNQLLEMAEEIRGVKFKVTYDSKESIKNGQVTIPPMPQGDSSSEEELKEMTALVSRLTVAGVFKLPDENRLNARFPDIQPVKMKQFLQNAWKGYKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTU7</accession>
    <name>B0XTU7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_029990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029990"/>
    <dbReference type="HOGENOM" id="CLU_069181_0_0_1"/>
    <dbReference type="OrthoDB" id="4436466at2759"/>
    <dbReference type="PhylomeDB" id="B0XTU7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="224" mass="25391" checksum="B0A9742FE28B72A5" modified="2008-04-08" version="1">MGIFSRFLKLTTIGGAATVGGFFWYTRNDVFVPLPLTDRIFHSARFNALNPLRNPTTHDLCIRRVPLSDIDPTLLEKKGKLVEAFCAGVWSGWGYAFQRAYLARKYQGPETANQLWSRSELRSSTYEPGTLITDHFEVVEKTPDRIVVRCGASPRVQEVRPSDGLFEMSVEVKPNEGVAEFGLKSCFFQGLGKAEAQPMPPHIVWLHQQYTKLWMEAAIRNVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTU8</accession>
    <name>B0XTU8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Prenyl cysteine carboxyl methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_030000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030000"/>
    <dbReference type="HOGENOM" id="CLU_065200_6_1_1"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="191" mass="21183" checksum="9DE9ECC959C6068A" modified="2008-04-08" version="1">MSAYHALVALLYAPNTNGSILPAICPHPENLSPKNLTWTPPVLLSLLTIASGAAIRLSAFGSLGRNFTFYLSVPDRLVTDGVYAYVQHPSYTALVLMCLGCAGLSWRWDGAVGACLLRKGAIERLDGLGVMVVGALWMVGVMLIRMRVRDEERMLQEKFGREWERWNARTASEYHLDTLDAIDTSVHHLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU02</accession>
    <name>B0XU02_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-SNARE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_019700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP53924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_022029_1_0_1"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="PhylomeDB" id="B0XU02"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="48811" checksum="C26D5954ACA471EE" modified="2008-04-08" version="1">MPEKRKPPTSASGLSPYSKRPRPSYAEEDDADEMTPALTPYERPRNHPVYGQKSAFPGLDVDVEDELFYGEAEDGMEYLRMVRSEANSLPFLFTAPKPAGTPTETTKVVITEEQEPEPASAPLRDGIYADGVYIAAPAEPEIAQVATGPQEDKYSEAQSSYYNLLHHRFLLLRSILKCTPPSSAIAALDDSHPISFPRHSKTARKEWRRLLLAVDPQTVQLACMDMDSVLAVLGIMARLMSENVRSGDAERVRRIGAWAWGLLGKCRDVGQLGTEEVGDIRDLGKRAVKILQKMREEDEKTTAARRDGGLSNEESDDDEFQEDDHGQPENAQENDLAAEQIGHEMQDSDREPPAEDLDAAKARLQAMLQGNANETLEPDKSDNVDVANHAEESRKDSAIEVAMQTRAMLDMIITVVGEYFGQRDLLKEREVWIGSSSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUL8</accession>
    <name>B0XUL8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_031340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031340"/>
    <dbReference type="HOGENOM" id="CLU_150823_0_0_1"/>
    <dbReference type="OrthoDB" id="2157103at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="134" mass="15065" checksum="C4D6A1550920BD90" modified="2008-04-08" version="1">MNIMNIHQSLCMAGRLPVRTSRLCSGKRLLCYTAQKSSKSDAKTGSCMIYPSNNRLSLLKFLEVQSPSEDPSKVRDNNQESKPKVTRSVAQADEELRERLEQMSGEGGASGIEYEDGKPTAMKRSVRNNMFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUS7</accession>
    <name>B0XUS7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_021120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021120"/>
    <dbReference type="HOGENOM" id="CLU_013782_1_0_1"/>
    <dbReference type="OrthoDB" id="5377952at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="2">
        <location>
            <begin position="523"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="766" mass="83474" checksum="9316F880D4281B47" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUS9</accession>
    <name>B0XUS9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_021140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021140"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B0XUS9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001591">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="449" mass="49293" checksum="4CF68B39131DF1B1" modified="2008-04-08" version="1">MLSATALITWAPKCSESHFYKKSSKDIVPSPCFTTKATTIGFLRTVPETGDLSMDTEAKKLSSAASTEADAALGFLASEGTAAFTEIVEEKLVRKIDWTIVPLMWYKRNGKVYLSWRGPLLTFAKQPKRIGFWYLGTGTATIIGALVAHGLLFYTGGCFRSWQIMFLIFELITIAVGICFMIFLPDNPMASRLAHEEKLFAIESLRENRTGIENKHFKMYQFVEVFKDPPTYFIAVIVAAMNISNAAISSFSVLIIRSFGYTTKETELLTIPGGVVSVISIVTGTYLAGRFDQRCLSLIGILACGLLGGCLMAFSHEGMKAAELAGNYLTTCVGAALPLMYSISGANVVGHTKKVTLNTIVLMSFCLGNILGPLTFRTEDEPDYMPAKIAIVATVSVAVVFSVLLKRYYMYENRRRDIQAEGHGPENSDFLDLTDRENPVVYGIACSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUZ5</accession>
    <name>B0XUZ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroxy acid dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_031970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031970"/>
    <dbReference type="HOGENOM" id="CLU_014271_3_1_1"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="PhylomeDB" id="B0XUZ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009560">
        <property type="entry name" value="PRK13017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="101"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="7">
        <location>
            <begin position="425"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="654" mass="71228" checksum="638A7B5947B278A1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV51</accession>
    <name>B0XV51_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_021670</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV51"/>
    <dbReference type="SMR" id="B0XV51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021670"/>
    <dbReference type="HOGENOM" id="CLU_005965_7_0_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="PhylomeDB" id="B0XV51"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760489" description="Endoplasmic reticulum chaperone BiP" evidence="15">
        <location>
            <begin position="40"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="672" mass="73385" checksum="DD08BB303C37975D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV68</accession>
    <name>B0XV68_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RanGTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_021860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021860"/>
    <dbReference type="HOGENOM" id="CLU_014536_1_0_1"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="PhylomeDB" id="B0XV68"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="666" mass="75209" checksum="B4A45D6D67D7A9AF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV84</accession>
    <name>B0XV84_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_032220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032220"/>
    <dbReference type="HOGENOM" id="CLU_031491_2_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24666">
        <property type="entry name" value="zf-C2H2_fungi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="395" mass="44183" checksum="77993129EFD16434" modified="2008-04-08" version="1">MHNPATPKTVLCTFPDCPCRFNTIGEMKKHKSCAPEHEYCARCDEDFENEERHLIHKIKSNKHIVCPICSVDFRSEGGRDGHIRQYHRAEQTLTCYGCKALFKTAGGLMRHIEDDECPEITKRRLLEERSKKIMIKQALGTGVGLPLLILPRPGDLDEVDGGVKVNPLEYDNREAMANQPKPSEDGSATLSQKHWPELKTAAKSRATGNPTPADLMAFSDLAITDKAGNGDWKGKGRLITLPKFEKEKDENERPFGVGAPDAGQILRFLQHNWDPTNFSDSYSGEYVCPCKARFKTMKVFEEHMLMKSQGARGMECPGCHRIFKTIAALVAHCESSTKRCHINTNSQFSQIIDEVSAGVIQAAGYMPDGTVKYEAGKLELTKTTTIGVELEKNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVI7</accession>
    <name>B0XVI7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_022390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVI7"/>
    <dbReference type="HOGENOM" id="CLU_006926_1_1_1"/>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="PhylomeDB" id="B0XVI7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="255"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="669" mass="75300" checksum="11807C9C2CE31C83" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVX2</accession>
    <name>B0XVX2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_023110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023110"/>
    <dbReference type="HOGENOM" id="CLU_082177_3_1_1"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="PhylomeDB" id="B0XVX2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000013">
        <property type="entry name" value="37S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="190" mass="21633" checksum="524007DDC6B1336A" modified="2008-04-08" version="1">MVFNILSPLPFRSSGLSLGSFSTCRWSSTLPSKTAHQRPAALFQNRVFQRRRLPNRQKFLEDQKAQGESRALEKFQTRDWKAGDIYAPHDLSPAEMKKWRKRQGPAADAFDALNLNPLDLYKNFSIMSEYMTAMGRIKHRSATGLRPVNQRKIAKAIRRAIGIGLMPSVHRHPEILAAEAKARMEGTPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVX6</accession>
    <name>B0XVX6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">mRNA splicing factor (Prp1/Zer1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_023150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <text evidence="2">Associated with the spliceosome.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EDP54259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023150"/>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="PhylomeDB" id="B0XVX6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000410">
        <property type="entry name" value="Pre-mRNA-splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000304">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
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        <location>
            <begin position="606"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="926" mass="104017" checksum="A19AE1903D876297" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW82</accession>
    <name>B0XW82_ASPFC</name>
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        <submittedName>
            <fullName evidence="8">DUF803 domain membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">AFUB_023900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_012349_5_1_1"/>
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    <dbReference type="PhylomeDB" id="B0XW82"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
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    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="741" mass="80523" checksum="636FE71F6A3C0F16" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWB5</accession>
    <name>B0XWB5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_024230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 8"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024230"/>
    <dbReference type="HOGENOM" id="CLU_033449_2_3_1"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="PhylomeDB" id="B0XWB5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF31">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="9">
        <location>
            <begin position="76"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="10">
        <location>
            <begin position="245"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="396" mass="43220" checksum="CE37E4302BCE0FAA" modified="2008-04-08" version="1">MTSVLNTAAADNLTHPVLNVTGKVISSIVTLKFYSQGHSGRLGKIGIGIDDRQNPGRKHSRTSRCLRRRGADVGTHKLTDIINRVHENVKYLPGTALPSNVVANPDLRAAVKDATILVFNLPHQFIDKTLEQMKGHHLPYARAVSCVKGVEVANGRVTLFSELIMEQLGIYCGSLSGANIAPEVAAEEFCETTIGYSPPPMDLDAKDELSPDNRHRVPDDYPCVDERLLRRLFERPYFHVQVVADVAGVALCGALKNIVALAAGFVAGKGWGESSKAAIIRIGMMEMIRFGRFWFPDSVNQKTFTEESAGVADLIASCSAGRNFRSAKHSVEKGVSVDELEQSELNGQKLQGTSTTRAVCDFLSTHGKLDDFPLFNAVNRILDGKVSVDELPKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWH4</accession>
    <name>B0XWH4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidate cytidylyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_035930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035930"/>
    <dbReference type="HOGENOM" id="CLU_031477_2_0_1"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="PhylomeDB" id="B0XWH4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="386" mass="42148" checksum="F87600CB33DB407E" modified="2008-04-08" version="1">MPSSSADDIPATPRVISPSPVPSSESSSRDGYAGPRTRSAARRQRLVDVSEEKSEDVDADSTRSRSRSPAAPARLTRTRRSNPMIPARKPEPSKTNGRISPTDLLSPNSALGKGRAHDISRSPSPLGLIPLHTRYRSFIHRHEIPRKLLHGSIGFLTLYLYSRGVQTLQITPWLLSALVPIAATDFIRHRSETFNKIYIRCVGALMRETEVSGYNGVIWYLLGAYSVLRFFPKDVAVMGVLLLSWCDTAASTFGRLYGRHTFQLRKGKSFAGTLAAWVVGVVTAAAFWGWFVPRVGAFPNDPEGSFMFTGRLNLLPDPIKGLLGWTADSDSSRGVITGPLALGVMSVVSGIIAAGSEFIDLFSWDDNFTIPVLSGIGLWGFLKVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWP6</accession>
    <name>B0XWP6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_046860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046860"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="PhylomeDB" id="B0XWP6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="257"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="451" mass="49631" checksum="CAB2E2BBFB933F3E" modified="2008-04-08" version="1">MMATNELESVPPVLFKETFSHIPTSSDDLSDDIDEFDDSRLPPVDGGYQAWLFLAACFMVEGIDSHNRSGSLRTIIELMSHFRTRLRLRPLGPAQWSDRYSSGLAYLPTPIVIAIMFAFPRARRWFSTAGFVIMCLALGLSSFSTSVTHLIMSQGVAYGIGGCLAYTPSILFLSDWFVEKKGLAFGIVWSGSGLTGILFPLILQTLLNQYGWQTTLRACSIALFLLAAPFMTFHKPRVPIRHSHLRQLSLRFLWDKVYLIYQLGNTMQAIGFWIPSIFLTSYARTLGASDFLASLTVTLFNLMTVFGCIFTGYLADRHHVTKCILLSSAGAVASVFLLWGLANHIATLYAFCIVYGFFAGGYSSSWSALSHEVQKSERSAHVSMVFAFLETGRGVGNVISGPLSEALLKVGGWKAGAFGAYGSEYGVLVVLTGVTAFLGGFASMARMFRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWQ3</accession>
    <name>B0XWQ3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_046930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046930"/>
    <dbReference type="HOGENOM" id="CLU_068720_2_0_1"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757978" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26918" checksum="F131E70C27897FD8" modified="2008-04-08" version="1">MHYAYISIPLTLALGVTASMPADSWVFGNSLFYLGPPTGASITKATYSLVPPDVPSGVKVSSPSDQVWVSVWVGASSTNGDANANLYQPLLNWSPDQESQGCLANSTEWCVAASTYTPDGQVGQTYVPVPPQTNLDFEISVENNKVYQTVTMNGEVVSQQSDALDNDLKYLYSSNECYTGSGNCGLLQGYKITNVTVTLSAADESFGKTMALFSCTDAGFATTDNGRTWYTDYIAIQEIDFDSSSDASVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX44</accession>
    <name>B0XX44_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_047680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047680"/>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="PhylomeDB" id="B0XX44"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000739">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="199"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="335" mass="36784" checksum="29FAC181C30CF6D4" modified="2008-04-08" version="1">MSPKARVLLVGAGGIGTIAALNLERGGLAEVTCVLRSNYEAVRSRGIEIISCEHGHIKNWRPTAVLNVIPRVCSEDHSTLFDYIVCTTKNIPGVTPSICETIAPAVRPGHTVIVLIQNGLNIEKPFLSRFPQNVILSGVSRCDAHEIAHGVIEQKEDDDLHIAAFHNPLLDQETQQKAAEQFVQIYGAGGKTNVRHEPNWERDRWSKLVYNATLNPICALTGVNTGDLQIAGSALDRLVIPAMQEVVKVSKAVGVELPDDIIETTIRKNPVERKIAPSMQKDMEKGNLLEHENLIGEVVREAQKQGVAIPVLSVLYELCSAIQWRVAKERGMRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX85</accession>
    <name>B0XX85_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_037180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037180"/>
    <dbReference type="HOGENOM" id="CLU_1488682_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="181" mass="20363" checksum="3132A796F4549A37" modified="2008-04-08" version="1">MSEIIVCYGPFKALKYFFPFSAGQGDLWRYSSKSSHSVVLTVIFVRPKVRDYFSDPSPITFDLSAALYCATIHVEFRHCAFSLSNTIPVDLSSFMLSYPFCAFFAALLKAEALTSHGSISSHKGEKKTTRRTPTETWGSPSSIRRLLLLSVSWAYLFLPIVLLLLLLRPSLSGSCRREYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXH9</accession>
    <name>B0XXH9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_048390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048390"/>
    <dbReference type="HOGENOM" id="CLU_017779_3_2_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="PhylomeDB" id="B0XXH9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="146"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP53653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="575" mass="63187" checksum="B965FCC2FE60527C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY05</accession>
    <name>B0XY05_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar iron transporter Ccc1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_039200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039200"/>
    <dbReference type="HOGENOM" id="CLU_038957_0_0_1"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="PhylomeDB" id="B0XY05"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="301" mass="31931" checksum="D4EAA88A2EFCE0DE" modified="2008-04-08" version="1">MSLSSIKGLLSNYSPVSESLDLEKIYHYPLRNTSEDLESASGSEANKPIQREGGEKKESKIIDGRTVSDAIIGLSDGLTVPFALTAGLSALGDTKVVVFGGLAELIAGAISMGLGGYLGAKSEEESYRATLKETRNKVVADPSATTETISEIFAPYDLPSELVSQLTDHLSASPMLPSFLMNFHHTLPEPSGSRALICALTIALGYFIGGFVPLLPYFFVGPHDAFIALRWSIATMAIALFLFGYGKTCFVSGWRGRQNIRRGFIGGMQMVLVGGVAAGSAMGLVKGFQLLASIGEGHGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZI9</accession>
    <name>B0XZI9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Periplasmic nitrate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_034030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034030"/>
    <dbReference type="HOGENOM" id="CLU_000422_13_4_1"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
        <property type="entry name" value="MopB_CT_Nitrate-R-NapA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.228.10">
        <property type="entry name" value="Dimethylsulfoxide Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041957">
        <property type="entry name" value="CT_Nitrate-R-NapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF10">
        <property type="entry name" value="NADH-QUINONE OXIDOREDUCTASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin oxidoreductase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Molybdopterin dinucleotide-binding" evidence="9">
        <location>
            <begin position="559"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="909" mass="102251" checksum="AA0B65224607D440" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y029</accession>
    <name>B0Y029_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein CSS2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_045420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y029"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045420"/>
    <dbReference type="HOGENOM" id="CLU_056568_0_0_1"/>
    <dbReference type="OrthoDB" id="4366245at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046624">
        <property type="entry name" value="CSS2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20521">
        <property type="entry name" value="DUF6736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Secreted protein CSS2 C-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="406" mass="43451" checksum="F6AA93C148E955DA" modified="2008-04-08" version="1">MTKSESDQNSCSLVYGTDSDGTYVEGYAYEATTSGENCDTTAKKKTIIAAYHVQFGFVPWPHNVAVWELRVYKQPALWVLVVCQFSFNGAGNSNLSTATRSTHSKDGKPDGSHLARPESRFGEWILKRDTTTITDAVTSTTAIETVTSATTRDSHATTTSDSRTTSSSETSSSFTTTTAAATTTSTTTSSTSSSTATSSSSASIAASTTTTTATRTTITSTTTPTPTESAELKEWNHRGTIAAIVTFSILGSVFVGACIARCFRNWAKKRHIKARKQPDQESSLYMLGPTAENAKPASQVKLDRESIMFCDERSVPSLSGQSYWQGSMGRSSLPSEDVGRSMSSGRHTPLGVREQHGTAEAQPRCQPPDSSLPDDASTTTRLISWRSSSTSTSPALTARSNGIRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0Z0</accession>
    <name>B0Y0Z0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argonaute siRNA chaperone complex subunit Arb1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_059010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0Z0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059010"/>
    <dbReference type="HOGENOM" id="CLU_023193_1_1_1"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0Z0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54725" checksum="C74E1696C4787116" modified="2008-04-08" version="1">MTMGSPEIASNTSHELPLRPLEQVNDPEPEQPNMATSPEHQTSKPIEMTPPTSEVDGIQQELESMPVNVNKPTGFEEYYVDAPITPQEYAEGREIYDVRMEDAILRFQKKRRIESDRRDVFLKYLQYGGVDISAKMFTGTDQRNLKEMDSEGVLLARAQTSIAQEQLNLQIDFNAVVKGYLTSYFPYYFNPETEDMVKLATVTIWNFLTYILYHDVAPEYKANIEEARKSCDIAGKELWKNQQFTSKGPGDFNTACSTLFGGVFFDLYVENNQWNNSKDDTVRMTNGIARKVVKFALAGAGIDRQVVQFQELANEDALRAMRVQDIDGFEVTAIIFPDGETKEFYQVHAPDLHPVGRMLAKAYRDPGKPDIDLSPEERLQWEKGGAPALEFDFFLEETLLKFCYPGMKVITAVWELNCGFHYFDEISTAYCSIYTVLANDLMIGWKKPKDLRVGDDREADETFDEEGKDSKRKETEGPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y125</accession>
    <name>B0Y125_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_059360</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="PhylomeDB" id="B0Y125"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1957"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2613"/>
            <end position="2763"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2955"/>
            <end position="3121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1657"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="3217"/>
            <end position="3279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="3443"/>
            <end position="3484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP51916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="4368" mass="494693" checksum="71764A0195D60305" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y171</accession>
    <name>B0Y171_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_048900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y171"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048900"/>
    <dbReference type="HOGENOM" id="CLU_097601_0_0_1"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="249" mass="28519" checksum="BD9EEA6054222943" modified="2008-04-08" version="1">MATDQELPLFQVHNDPESVRAVADTITASFADDPLIRWQGPLAGSWSTSDPNTSEWQYRRVLKAVADGIVFISATVAEVDRRFHKDGKLCERSIVERDAGVVALLFPPRRRCRWTLGRILLWLKVWFLDIVSPVHEKGANDKRLKQLMDAHERVVTNVKDTYRISDLWYLEVIAVHPYLQGRGLGKKALRSVLDHTNDEPIILECTKEDNVVVYERLGFKVVEEVELVQDGAGVKLWFMLRQGQQKQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1I7</accession>
    <name>B0Y1I7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, 2OG-Fe(II) oxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_049440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049440"/>
    <dbReference type="HOGENOM" id="CLU_010119_8_5_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1I7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000094">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="175" mass="20216" checksum="9D9E7666028EEDD8" modified="2008-04-08" version="1">MDYLNQVTALTEKALQAIGVSLGYDESYFDEICTEPMAFYKLLQYPPQPADADPLQRGDVPGLEVWDEESQSYYPVPPIEGAYVVHLGNLFQQWTNDKYMSNVHRVINRSDVDRYSIPFNYNGNLDFVIRCIESCRAKPEDEKYAPISVDDYIRQKYKDVYGRVGIYSVAERVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1P1</accession>
    <name>B0Y1P1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-dependent flavin oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_049990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1P1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049990"/>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_1"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1P1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="442" mass="47081" checksum="E4A11B06D31912C1" modified="2008-04-08" version="1">MGSNAFRSPAVTKSSSTPYYTPANNGGAALHPDDPTTPTLFRPLQIRNVTLKNRIMVSPMCMYSCESDPSSPHVGALTNYHLAHLGHLALKGAGLVFIEATAVQPNGRISPNDSGLWQDGTTSEQFLGLKRVVEFMHAQGAKVGIQLAHAGRKASAVAPWLAAQAGKSSLKADESVGGWPADVVGPSGGEEHIFSPEEDAYWVPRALSTAEVREVVAAFAKSARLAVQAGVDVIEIHGAHGYLINEFLSAVTNKRTDEYGGSFENRTRIVREVAAAIRAVIPEGMPLFLRISATEWLEGQPVAAESGSWDMQSSLELVKKLPEWGIDLVDVSSAANHKDQKINLHTAYQTDLAGQIRQAIRAAGASTLVGAVGLITDSEQARGLVQGADEATAAEAMLSGPEPKADAILIARQFLREPEWVFSTARKLGVPVTVPVQFGRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2B1</accession>
    <name>B0Y2B1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_050830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2B1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050830"/>
    <dbReference type="HOGENOM" id="CLU_050230_0_2_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2B1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="275" mass="30626" checksum="CD9715E926DB0C3C" modified="2008-04-08" version="1">MHKYCALSNTRPCLRPLQTTMSKMAELEIIDSKGLPLIKGDYCPAGPGHLRAPCPVLNSLANHGIIARSGRNITAAELKAALRYLGMGIDVITILVNGAFKVHSDDPKKGALLGLRDKDQTNEDGVPVLNLDQVGRPHAVEHDVSVTRQDRALGDCMRVNADLLERFLAAPKTERGFSASAFGKYRKTRYNEQKRDNPALEFDRFNHFSGCAELGAVQCIFGRGFPYRVPEEYIRVLFGEERLPIEEGWKPRRLPLLLPELAPVILRISHFASPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2M5</accession>
    <name>B0Y2M5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_062350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2M5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062350"/>
    <dbReference type="HOGENOM" id="CLU_082183_0_0_1"/>
    <dbReference type="OrthoDB" id="3880401at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="227" mass="25438" checksum="723FE2DF7B4D3040" modified="2008-04-08" version="1">MGSNDTTEKLFHILLTTSHLQKNPNNVVEKVRIPGTYTTVQAAKAAAYRCLFDAGYEKEWFTTYETKPEIFENKDLPERSGLAVFAVAPDGTEFRVHIITTPKDDKLLDEVIEGHVTKPLYYVVQANVEYSADEGSRVRDIDIEGVFLTYQEARDLASRVLLSKENAVTKESFAEYTEAAATEKDCGYGENVVVRAVSEYGTNYLISVIKNQELEAVHLAEAAMRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2W6</accession>
    <name>B0Y2W6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_052110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052110"/>
    <dbReference type="HOGENOM" id="CLU_052850_0_0_1"/>
    <dbReference type="OrthoDB" id="5339332at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="416" mass="45351" checksum="25CBFBFDB23BD91F" modified="2008-04-08" version="1">MDYRSDRLSSHHGVQLSPSLSGQKWSQLTPSHSRPVVETVGPSHQASSGRYRVALDTSARTYRTTALRQINGNHRPPSWVNRQANRSGNRSSTLASQPVLVRAYSGSTDDTGEISNMPSRLSFPFSVRSGTPKRGPSLPSEDDFSIDGILRAIEPEIRNTLDAIGEICGRSKLSLANEYGSHIAPLGEIRAPPGGLLTVEEASSDHERQPDDAMIIFDDDSNSVMGVRDYTTLPQYRYLEQTRPSTIPPSTMGYHSFVPFSVAEGLSVLAQSANLDENTSDPVADSLPATREFMSKPNSSGRTLLGKQSECITEDHLKSILTPALVAEIRLEAQANGHSLHALPSDSRRGQLSAAENGDTATRDGGQTDKLSVLTDVQALFNWLRNASQDGQPRSAEKLLRAMLEKQNEHPPRNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y359</accession>
    <name>B0Y359_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rheb small monomeric GTPase RhbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_053040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y359"/>
    <dbReference type="SMR" id="B0Y359"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053040"/>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="PhylomeDB" id="B0Y359"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="187" mass="20885" checksum="38CF19D55C25543B" modified="2008-04-08" version="1">MPAAPKQRKIAIVGSRSVGKSSLTVRFVEHHFVESYYPTIENTFSRIIKYNGQDFATEIVDTAGQDEYSILNSKHFIGIHGYIIVYSVASRQSFDMVRVIRDKILNHLGADHVPLVVVGNKSDLKSEQRQVSLDEGRQLGEEFQCAFTEASARLDYNVTKAFDLMIGEIEKSQNPSQPAGGSKCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3K8</accession>
    <name>B0Y3K8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_054570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3K8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054570"/>
    <dbReference type="HOGENOM" id="CLU_040397_0_1_1"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3K8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="294" mass="32210" checksum="33D37706E1624914" modified="2008-04-08" version="1">MVHQPQHAPPSSKGFDLSRWHFDIDAYLNPYLPAPPWRWLPRPVSHFFGYRGDQPPKAVGNLVIAFWALIGAFCGVLVIAEVSLHVPSFQAHHAPIIVASFGATAVLEFSAIDSPFAQPRNVIVGQLAASIIGVAIGKLFALNPHAHSLPQVGGALACAITIAFMAITNTTHPPAGATALLAVTEVFELGWYLVPVVLLGCALILSVALLINNIQRRFPVYWWTPHSLARPKLEDVESIGHEKVSSVKPTESEDSVTDEPEEIIIRRGEVLMPDNLWISAEEREVLERVSQRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3X7</accession>
    <name>B0Y3X7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_055780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3X7"/>
    <dbReference type="HOGENOM" id="CLU_070130_0_0_1"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3X7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000068">
        <property type="entry name" value="NUDIX family hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="310" mass="34113" checksum="1F79589AA7FD3C76" modified="2008-04-08" version="1">MRNRLWLSVRHLHPTGFSNPIVPSVTIKPMSSFTIPFDVGNGSGSVPVTSLNDLSKDDLLCFPAFQIWLSTLQRSLQRQHNPSHEFSHNPYVLRKINVQSVDYFKGGRLGFVKLKADVSNGHGETLPGTVFLRGGSVGMLMILQPDDVPSSNEDEKRAILTIQPRIPAGSLAFPEIPAGMIDDSGTFAGAAAKEIEEETGLTIPQGELVDMTSLALQSISEPKDGEYLQRAVYPSPGGSDEFIPLFLCQKRMPRKEIESLQGRLTGLRQHGEKITLKVVPLKDLWKEALRDGKTLAAWALYNGLKQDGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y481</accession>
    <name>B0Y481_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent 15-hydroxyprostaglandin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_056830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y481"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_2_1"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="PhylomeDB" id="B0Y481"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000643">
        <property type="entry name" value="Short chain dehydrogenase/reductase family oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="322" mass="35141" checksum="94221545FD32C6CF" modified="2008-04-08" version="1">MAFSVKGKSAIVTGAGSGINLCFAKLLLENGCNVLIADLALRPEAQEVVNYYSSQPSRPNRAVFQKTDVVDWEQLERMFEVAVREFGDVDIVCPGAGIYEPHWSNFWRPPGAPESRDPRDGGRYALLDINLTHPIRTTQLAISHFLRNRSSKRPKHIIHISSIAGQSPALAAPIYVATKHAINGLVRSLAKLDSKFGIRVTAVAPGVIKTPLWTDHPEKLKMVDDKADEWVTPEEVAEVMLALIQQDSVSEIIGDKSGHGTQFPVQGGTILEVSKSVRAVSPFNDPGPAGRRGNTVSDMAKVEDEVYDLLSTEGWGAPKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4C6</accession>
    <name>B0Y4C6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_057280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057280"/>
    <dbReference type="HOGENOM" id="CLU_1503117_0_0_1"/>
    <dbReference type="OrthoDB" id="5207033at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="179" mass="20455" checksum="FCF0E8C7CDBDC5FD" modified="2008-04-08" version="1">MSSPALTSIISRPENRYANYPEGSIDDSPVLRQKNPNVFFPPEFFPVIRADLNGTFFCDYDIDGDGNVTKHISWACFKIKHVVKPGLYTWIQTAVFVQWHPQANRQLVFFLNLPDVMAQYLAVHRPSPAQRGNPFIWHTLFAQGVVEEYDSSIWSLRHLVRPIEKVAIYPSGQCSDSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4Y0</accession>
    <name>B0Y4Y0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_070690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4Y0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070690"/>
    <dbReference type="HOGENOM" id="CLU_095070_1_1_1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4Y0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="153" mass="17066" checksum="A3DDE295FA6FD1FC" modified="2008-04-08" version="1">MTNLQVILSPVPPSATPPISLPINVAIHNPAATPVTFVNWGTPFDPKANLLGVFQINDTATDHPITLDTIKFQRRLPPSREDLVEIPAESSMERTITIPHVPLEEGHEYAVQAKGIWHGIWECARNQVTDAQLQELDQRGEFESERALFKVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y553</accession>
    <name>B0Y553_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_071430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y553"/>
    <dbReference type="ESTHER" id="aspfu-q4wqw8">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071430"/>
    <dbReference type="HOGENOM" id="CLU_043694_0_0_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="TesA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase TesA-like" evidence="1">
        <location>
            <begin position="41"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="275" mass="29493" checksum="FDC97DD3A294A52A" modified="2008-04-08" version="1">MAINLIDPHLVLVDHASSIVLQGSSRSAEKILFLLPDGSGSATSYASLPRIAAKVAVIALNSPFLKNDVDVHCTVDELVGSYLKEIRTRQPTGPYHLAGWSAGGILAYRAAQILLARGEQVPCLVLLDAPPPMGLGTLPQHFFDHCDAMGIFGQEGKAPEWLIPHFKKTNAILSGYYATPFVAGQGPDRTGIIWASQSVFDSKGCARPAPRPEDTEDMKFLTEARTDFSAGIWGSLFPGAEVVVDKADGANHFSMMQEGKYARQVAAFIGQLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5N2</accession>
    <name>B0Y5N2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Outer mitochondrial membrane protein porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_063980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5N2"/>
    <dbReference type="HOGENOM" id="CLU_044399_0_0_1"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5N2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="345" mass="36894" checksum="E65F17280137FAF4" modified="2008-04-08" version="1">MSAPAAFSDIAKAANDLLNKDFYHTSAGILEVKSKAPNGVTFNVKGKSAHEGPIAGSLEAKYVDLPTGKRPITRKPPDPSTRKTGEARSMFSFTCGQVSSAYFRFLFMTRIVAHSVMLILCPHPGLTLTQAWTTANALDTKLELDNNIAKGLKAEILTQYLPSKQSKGAKLNLYFKQPNLHARAFFDLLNGPSANFDAVLGHEGFLVGAEGGYDVQKAAITKYSAAVGYSVPQYTAAITAGNNLTVFSASYYHRVNQQVEAGAKATWDSKAGNSVGLEVASKYRLDPSSFAKACRSAKINDRGIAALAYNVLLRPGVTLGLGASFDTQNLNQAAHKVGASFTFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Z5</accession>
    <name>B0Y5Z5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_065120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Z5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065120"/>
    <dbReference type="HOGENOM" id="CLU_002712_0_0_1"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Z5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127968" checksum="60F1396E85353A74" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y647</accession>
    <name>B0Y647_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_065640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y647"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065640"/>
    <dbReference type="HOGENOM" id="CLU_035272_3_1_1"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="PhylomeDB" id="B0Y647"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="209"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="404" mass="44257" checksum="4AB0129D6B2C998C" modified="2008-04-08" version="1">MASDDGPQEIAALLLLPPPPAVKFEQFKGAYEPTLSTVFSKLCKTLNGVNSIAILDIAISIPGLVSRSSQPRAKIFPSLQHYLANIYRLIGIVSAEHSIELDAPGGIDARVIFIDFPTTSAEDRQAPRHGPILDLHSLANSARLWDWIYYPENKAGQQLATAFDSIYSKNKDPNAGSLHALSNQPDWPSPRTLIVPEVKAQSPHYSVAVGGTFDHFHIGHKLLLTATALALEPVEEFDPIPERYLTVGVTGDALLKNKKYAEFLESWDDRCQSTSSFLLAIMDFSRPNESAPRIERVSQPGPNGHYVLMKVRCGLTLKLVQITDPFGPTITDESIDALVVSAETRSGGAAVNDERAKKGWKSLDVFEIDVLHSGEVPTTDGESFASKISSTDIRRRRMEMATAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y675</accession>
    <name>B0Y675_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_065920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y675"/>
    <dbReference type="HOGENOM" id="CLU_015532_0_0_1"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="PhylomeDB" id="B0Y675"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="334" mass="37306" checksum="EA5777A40FD0B45E" modified="2008-04-08" version="1">MKILGRYGVEGETPDVRRAALRCVANALLLDDKMRQIFADTGYGSKLAEMLKQIIRHAKQFPKSGKKPLVQIDELALTDTLKLIFNVSKVYPDLSATFSPSIPYIFKIISRIDIPPKPLDGLLGYLLNCLSTLDLENKKGKHFESSPIFPTFNQNCNVDKLINILDQAVSAYDAQDLATKAIPLLHTLVTIYEVAPDGPRKYMQWLLLPEDSDRKQPIGKSDTLSSKLLRLSTTPYQNLKIAISELMFVLSGKDAENLTKNIGYGFAAGLLASRGVEIPQSASEAFATNSNSFDPEINPITGQRWDAEKQDTGPPMSREEKEREAERLFVLFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6A7</accession>
    <name>B0Y6A7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_066250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066250"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6A7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002040">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="857"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="141"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="521"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="818"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
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        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
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            <end position="775"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP50292.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1397" mass="154901" checksum="0CD1A3FAEFF67388" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6D1</accession>
    <name>B0Y6D1_ASPFC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AFUB_066510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="627" mass="68087" checksum="A92EC8B78E7697A9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Q8</accession>
    <name>B0Y6Q8_ASPFC</name>
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        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="18" type="ORF">AFUB_067810</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
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                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="B0Y6Q8"/>
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    <dbReference type="PhylomeDB" id="B0Y6Q8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="RHEA"/>
    </dbReference>
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        <property type="term" value="P:box C/D snoRNP assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="63"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP50443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="458" mass="49720" checksum="F8049AAA5D37752C" modified="2008-04-08" version="1">MVQISEVKGSSRENRTAAHTHIKGLGLRPDGTAEPSADGFVGQAAAREACGVVVDLIKAKKMAGRAIMLAGGPGTGKTALALAVSQELGTKVPFCPIVGSEIYSAEVKKTEALMENFRRAIGLRVRETKEVYEGEVTELTPEEAENPLGGYGRTISHLIIGLKSAKGTKKLRLDPSIYEAIQKERVTVGDVIYIEANTGACKRVGRSDAYATEFDLEAEEYVPVPKGEVHKKKEIVQDVTLHDLDMANARPQGGQDVMSMMGQLMKPKKTEITDKLRQEINKVVNRYIDQGVAELVPGVLFIDEVHMLDIECFTYLNRALESSISPIVILASNRGHTVIRGTDDITAAHGIPPDLLARLLIIPTHPYTPDEIKTIIRLRAKTEGLNITDPALDKVADHGSKVSLRYALQLLTPASILARVNGRPGGIEEADIAECEDLFLDAKRSAAIVSQDSEKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7B6</accession>
    <name>B0Y7B6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ABC transporter (Adp1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_073240</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7B6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073240"/>
    <dbReference type="HOGENOM" id="CLU_000604_57_1_1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7B6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758701" evidence="15">
        <location>
            <begin position="26"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="909"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="946"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1062"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="373"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="634"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP49297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119927" checksum="5A6318FC5D08A7CF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7L0</accession>
    <name>B0Y7L0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SCF ubiquitin ligase subunit CulC, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_074180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7L0"/>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7L0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="385"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="766" mass="87630" checksum="8D2F18610F9DAC31" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7M1</accession>
    <name>B0Y7M1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1750-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_074290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7M1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074290"/>
    <dbReference type="HOGENOM" id="CLU_013398_0_0_1"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7M1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="4">
        <location>
            <begin position="270"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72769" checksum="51D9726129EC5DC1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7X6</accession>
    <name>B0Y7X6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_075360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075360"/>
    <dbReference type="HOGENOM" id="CLU_010365_8_0_1"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7X6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000071">
        <property type="entry name" value="Cell surface metalloreductase (FreA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="102"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP49507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="392" mass="44888" checksum="B1E91F92B87E5D09" modified="2008-04-08" version="1">MLDHQKFSLHEQSNLFAVIGAGSLVGLMLFSLSLFRRLSFELFLRTHQALAAVCIYMTWRHLPSVSIFPRVYIYIPLAILLLSTFLHVLLFLYRNGILPPRTYPYASVMCRKKCENTQGSDEDPAEDTPLKIRMALPRPMHVKAGQYVNLWMPSVSFSSWLQCHPFMVTSWSPGRQDVLDLFVRTRHGLTEKLRARAAREGTASFTAFVSGPYGRSESVGEYESVLAVASGFGIAGVVPYIKRLLYGYNTSSVRVRRVHLVWQVQTMVSWMTMSLMTAMYVNLLWLGWLTTNWAQILEMSFYAEYKTKAGKARPFGVHHRATIYNGFPDYDSIISTEATGEHIERVSNSREERGKLLVLISAKDELQDHLTVIVRKYLDQRVKFHKVEFQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y864</accession>
    <name>B0Y864_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_076250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y864"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076250"/>
    <dbReference type="HOGENOM" id="CLU_1554899_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="172" mass="18970" checksum="DD93254B410EFCAD" modified="2008-04-08" version="1">MITPIPISLITIHGWVTQQRALSSSCLALVQSQPMSSTNRSLKSAGTSKSSCYQSSAAVKRAGSQVKFVDYDSWEGHFNGRFCDNGVDESTDKSNTRTGLMFYELNTWDLLGGSPWKRSDNQPFEGTFEGTVNKFAQITRLIDPDAKFTEQAFISDAGTASVASFNRTSRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8X5</accession>
    <name>B0Y8X5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical glutamine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_078890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8X5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078890"/>
    <dbReference type="HOGENOM" id="CLU_990387_0_0_1"/>
    <dbReference type="OrthoDB" id="4409343at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="281" mass="31507" checksum="DA2B8D0C6C4B4C44" modified="2008-04-08" version="1">MIRRAIEPGKTSTGEKICFVQKLGENRARFVVESSDHTRRLVESSDAGGFVAIEGARRAGVPETTRKETDILALRSRVRSGGIYGLTFVAVGEWDPTQKRLPFIVVGFYYSENEHVQAAEYAISKSNLGKILSPREAERLVVEGIVGHQSMSLREALSSQLTVDPWQSQSPHLHGVGQMQQPYLSFPQSLFNPPPDLQQNYFPQQLVPYVQQHATNLLPVQQQPYFPHPHIISQQALPQQAPVIPQQQQYYQQHPPAQVSLGISPMVQPHLHSYNSDGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y912</accession>
    <name>B0Y912_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_079260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y912"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079260"/>
    <dbReference type="HOGENOM" id="CLU_032141_0_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PhylomeDB" id="B0Y912"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09615">
        <property type="entry name" value="Jacalin_EEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760777" evidence="1">
        <location>
            <begin position="20"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="306"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="439" mass="47789" checksum="BF1209AB38EFB37F" modified="2008-04-08" version="1">MRSFHLVLAAGIPALAATAGEFNILALNVAGLPPILNGNDVPGDKSDNSRQIGRKFAEYGYDVIHVQEDFNYHAYIYETDNHPYRTPTSGGAGIGSGLNTLSNFEFTNFVRTKWATCSNAEGADCLTPKGFTSMRVRVDEGVYVDFYNLHADAGSKDDDVKARSANLQQLADYIKVNSAGNAVLVFGDTNARYTRTGDNIRVFQTQNGMVNPWVELILQGAAPAEGSNALLCQNPSTTNDCETVDKIFYRGSRAVDLRAVFWNYESNKFLSDKGTILSDHNPITTNFTWTLSNAFRQSDIFGGPHGTWFNDLDSLPTAFTGQNKPSKISLRGAERLDSVGLTVASGKSYTHGNTGGQLSELPLAANEYWTKAKLCQGQYRGHTRNFYLLATTSSGRTVSAGTATSDCKEFAAAPGWQIVGFYGQDGDEIDQLGFLYGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9L0</accession>
    <name>B0Y9L0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_081410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081410"/>
    <dbReference type="HOGENOM" id="CLU_1421129_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="191" mass="21364" checksum="D6D2547AF7A6A3CD" modified="2008-04-08" version="1">MGDLDTTAWDLFSKDPERLRVFLTGMKLLANFMPVTDAYGFTWVVESGYWGSQAHATAAICNEDPGVLKHRYILQDLPEVLDEVCIKDPEEIRGNQLMPVDFHQKQPVLRFTTSATVFMTLATKNVLVFSSELPMRRQTVDRSSWRMSSTICRAPNPSDGPGSMAIHSQSASRCFVLNSSIFTSKNTNSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9L9</accession>
    <name>B0Y9L9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_081530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081530"/>
    <dbReference type="HOGENOM" id="CLU_2621572_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="78" mass="8410" checksum="92AEDFFC44345B58" modified="2008-04-08" version="1">MTKQKLQFGVVRKEEHHYCGSSSILTINPGGTSTSMVVLPKGFGGGLRQVLHWGRGVAVFKGIGKDEVFAFVDFAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9M2</accession>
    <name>B0Y9M2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Toxin biosynthesis protein (Tri7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_081560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081560"/>
    <dbReference type="HOGENOM" id="CLU_032731_0_1_1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9M2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF60">
        <property type="entry name" value="BIOSYNTHESIS PROTEIN (TRI7), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="246"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="409" mass="46757" checksum="E91153AD5955DABD" modified="2008-04-08" version="1">MDLNSPSAWSILLTQWLLVQLLTGLTIAFSQPYSKVRPAVTVLVIALAYSFQTQVHQTLAETRARGPLAAMCWVNVLNAIDLLMSSRVSFDEQIAWMTKCGQSKTADSSYWRRLVWSIEMAFNYRRINTPWQIRAVPAFDRHDPGFVPDKVKFLRQCALRVCGSLFVVHFCTLDLRDAHLAGILSEISDSKKVLLPTWGEWTARRAILQMLFTISFGLLTRAAILGTYSLLAMFFVAVGAYEPVDWPPVFGNVSDMYSLTRVWGIAWHQILRKLVTSNADILLYDFLRLPHGIVARSLRLIMAFATSGLVHFFTDQGFGLSLNQSGALWFFCLQVPGIALENLVWWTCRGMINRMGFRWRRAIGYVWVSLFFLWVTPVWMNPIILRLYQDGQKIHEVPRSTEQDGIIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9S4</accession>
    <name>B0Y9S4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell cycle inhibitor Nif1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_082090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9S4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082090"/>
    <dbReference type="HOGENOM" id="CLU_033724_0_0_1"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9S4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39582" checksum="0015D8B2BBB681FE" modified="2008-04-08" version="1">MPLRNILHKKDKINDSGSQYPPDGPSNAVPEIKFIRSDTISHEVIDPSSFGGDVSEHKGDHGQSDLLEPSRPSSSTHRRSLNIFSRSRSPSESSEPASPSRPRGEHRLSQLLHRDRGSRSASSSSVNIPSDLPQISDDKVDEQEREAQWEKRATILAQQSPLFGSPAASLRSSPNRLETNSAGGARSRSSSHSQINDPEGDVNIQEAIRLHEAGELERSTEMFRQLADPDGLNNALSQVLYGLALRHGWGCPQDPDKAVTYLSYAAANSASIESQALQAGMKKGGAAKGELVLAIFELGNCYRNGWGVKKDPVAARQYFETAANLGDTDAMNEVAWCYLEGFGGKKDKVRYYLTPNCPSGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAW7</accession>
    <name>B0YAW7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKS-like enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_086080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086080"/>
    <dbReference type="HOGENOM" id="CLU_296646_0_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B0YAW7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF52">
        <property type="entry name" value="STEREOSELECTIVE KETO-REDUCTASE AF490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="2">
        <location>
            <begin position="6"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="1">
        <location>
            <begin position="153"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1017" mass="110994" checksum="1D1DFF78C1403466" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB61</accession>
    <name>B0YB61_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_091680</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091680"/>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="PhylomeDB" id="B0YB61"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="18">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="149"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="19">
        <location>
            <begin position="290"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="511"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP48451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="692" mass="77864" checksum="A255F8CBF97331A9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB78</accession>
    <name>B0YB78_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_091850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091850"/>
    <dbReference type="HOGENOM" id="CLU_1959082_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="128" mass="14825" checksum="56098B7CF00E78B8" modified="2008-04-08" version="1">MVSSVDMIYWELLDEFCWRPRSTIAERVHNVTTIPEKHRERERFVRLKIRHLQEYYTELGEESTVEYEEEGFTKPQETFDHGTRCAESCTSLPFTALGAGSHVYLPLCIGLFSLGCVVGLIAKRIIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB84</accession>
    <name>B0YB84_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_091910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091910"/>
    <dbReference type="HOGENOM" id="CLU_1261227_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="219" mass="24344" checksum="C6ADD23CB2F3AC92" modified="2008-04-08" version="1">MAGKSCPVRALDMTRSSAPLSDSHFGENWAYHKRLGIALISGGRRVRDLTTHPWLARQNPSIGFQKATSQGTLRLSSPACLGAKQERSKIGRLTMFLAVHPYPGGSGSRETMQDIWPRASKPSGNCKISTMARLALQEDTYCCCIFSPWWQVHVLNCPCQWVCLDHFPEPGYTIIKVCILLKIPLPLAPSNQATRKSSVIHDWVGVGECTWMWICAFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBB2</accession>
    <name>B0YBB2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein Pth11-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_092190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092190"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_4_1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="PhylomeDB" id="B0YBB2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="264" mass="29241" checksum="3B083F25E6E07711" modified="2008-04-08" version="1">MFYLACLGFIKTSVCWFYTRIGDKTLTRMSLIMMGIVGTQATVFVMVAAFQCRPIPKAWNTSLPGQCVEINIFYLANAALNILTDLLTYSLPIKVLLRLQMPVKQKLALGFILCLGLFACISSIIRISYIPTMLKSADFTYAISGAMYWSVIETNVGILAASIPSFKAIASRFLPRLIGEYSSGRKYGSSTLTGSKPIHWGFSRFKDSVTMTSLRTKDAEVMPTEIGKGYGSNTSEERIVVPNGKIWTTTQIETNVEITNTSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBP2</accession>
    <name>B0YBP2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_087340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087340"/>
    <dbReference type="HOGENOM" id="CLU_024934_9_3_1"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="PhylomeDB" id="B0YBP2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="436" mass="49064" checksum="1D306EF2EBCF2747" modified="2008-04-08" version="1">MVATQMMTSTPVDMRSWQTVFRLPPPDQPQSPPYHARRPHKKSRAGCLTCKRRRVKCDETRPFCRRCEKLGAPCSYGGSPRSQDLQKTNEPDGTVCSLSLKSLESMVSRVLATDSDCFDISTWKTANDTRPVTIVAFQHFTKYSTDTVGNPFIRQVMKSDMIRVAFGCPHLMYTILGVGSLHLNRIRPQDPTWRLAEVYFWQQAIKAYQAALSSKVSPHNVDELLSTCMFMGITSLCPDRFQPTDSWVLTNAPGAMNWLCLQSGIRTIIKLAGPYIQSSIWASAFQQTHQEEVQLYEEGVPQGREGLDPDLADLCGIDDSTTAASMNPYYEPLRLLAAISGLEKNMKNAAQCASFMGRLDNDFLALLRERDPPALLILAQWMGLLCTLSEWQPWVEGRIRGECTAICMYLEHSTDPRVRRLLLFPASACGYHLTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC29</accession>
    <name>B0YC29_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_088700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC29"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088700"/>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="PhylomeDB" id="B0YC29"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="133" mass="15315" checksum="82E10F51F1A55801" modified="2008-04-08" version="1">MADTPVTLRTRKFIRNPLLARKQMVVDVLHPNRANVSKDELREKLAELYKANKDQVSVFGFRTQYGGGKSTGFALIYDSHEALKKFEPHYRLVRIGAATKVEKASRQQRKQRKNRSKKFRGTAKTKGPKKNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCJ2</accession>
    <name>B0YCJ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_090380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090380"/>
    <dbReference type="HOGENOM" id="CLU_1786451_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="146" mass="16958" checksum="5D3669542DC3E531" modified="2008-04-08" version="1">MRVHVCLGQYLRWNWERFGTYVFDDFWTGGGFELELDDMDDGHFGSVYRLRLLGCDISTEKWSNADNCVWRMTKVGYIGQRFDNHEASGSKFTFGRDNTDEFFGVGTVAFYHSYELRCDKRNNDIEVLKDRGDAKSLDTISRCSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCQ1</accession>
    <name>B0YCQ1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_090990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090990"/>
    <dbReference type="HOGENOM" id="CLU_044237_0_0_1"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="PhylomeDB" id="B0YCQ1"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="175"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="269" mass="30249" checksum="A8881D3843792E0F" modified="2008-04-08" version="1">MSTEWDPTQFFCDSSQPIAPFALLVLNQPINERAFAVLKKHDSVQHRPELTDGNQLPNLIIGDLDSIRPSVRSHYEGLGVSVIKDPDQYSTDFTKCLKYLRAHAAEIITKRVISTQSRSARLEILIMGGLGGRVDQALSQIHHLYMMTREVAGESAAGDLYLISEESITFLLQSGRHTIRTPRTNRPGVCPEQGEDEYYLLEENVGIIPLSGPARITTRGFQWDVEDWLTEIGGQLSTSNHIRADEVMVETGVPVLFTLELAERFKRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEM2</accession>
    <name>B0YEM2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_099670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099670"/>
    <dbReference type="HOGENOM" id="CLU_020019_1_7_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="PhylomeDB" id="B0YEM2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000024">
        <property type="entry name" value="MIP aquaporin (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP47366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="313" mass="33488" checksum="A9A1D3F2FE209083" modified="2008-04-08" version="1">MAFGKRNGEERRVLHRTQSQLPMLGLADSARNNLIAVVGEFVGTFLFLFFSFAGTQVSNTPKPVAGAPPNTSNLLYSALSFGFSLTVNIWAFYRVTGGLFNPVVSLALCLVGGMPPLRGVLVFMAQLVGGIAAAGVVSALFPGDLNVGTRLGGGASISQGLFIEMFLTAQLVFVIIMLAVVKHKSTFLAPVGIGLTFFVTEMIGDYYTGGSLNPARSLGPDVINRSFPGYHWIYWVGPLLGSLLACGFYAFLRMFKYESVNPGQDYDEWEAKRNHGSFDGNGRESTAFSDSTAGAQSQSPRGVNRPVSGAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEZ5</accession>
    <name>B0YEZ5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_101030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101030"/>
    <dbReference type="HOGENOM" id="CLU_1383850_0_0_1"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="PhylomeDB" id="B0YEZ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="197" mass="22584" checksum="4FEF1C0E046DCFCA" modified="2008-04-08" version="1">MRQGLLTKLTTLNDIISHSSDQPYTFEAFVDFLARNHCLETLEFISEVKHYRESYNLSLARFSVSGKDPKEREDSYLFREWQHIKDAYIAPNAPREINIPGWMRDALMEIAPEVSYPPPILLEPVLHYAYEMLAEDAVLPFIRSLADIADTNGAGHLQHRRQAYEPPRIIRPVDETVTLSSPCFSPIPSGWKGRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0YFB0</accession>
    <name>B0YFB0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_102350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499607">
        <property type="protein sequence ID" value="EDP47062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YFB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_102350"/>
    <dbReference type="HOGENOM" id="CLU_008964_7_2_1"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="PhylomeDB" id="B0YFB0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="3">
        <location>
            <begin position="37"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="627" mass="71130" checksum="B2C4AEEAC0C80E2F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMM5</accession>
    <name>B0XMM5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_003270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003270"/>
    <dbReference type="HOGENOM" id="CLU_068508_2_0_1"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="PhylomeDB" id="B0XMM5"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="121"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP55630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="250" mass="26503" checksum="8FA176F7D37BDA1D" modified="2008-04-08" version="1">MPSQLNSAVRVHRQTRLTNTCIFLLGQLATLLDKYTAISLSSIHLTISTQVMTKETTPPPQQSKAPTHEPPSLPASPLAKRTKPDSNNTANSNKMTTGTAPAVTSISQPLPPLLVKKLTESAQAPTRGSAFAAGYDLYSAKETVIPAKGKALVDTGLAIAVPEGTYGRVAPRSGLASKHFIDTGAGVIDADYRGEVKVLLFNFSDVDFTVKVGDRIAQLVLERIYTPDVMVVEELEESVRGAGGFGSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN09</accession>
    <name>B0XN09_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_003980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003980"/>
    <dbReference type="HOGENOM" id="CLU_027977_2_0_1"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="PhylomeDB" id="B0XN09"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000043">
        <property type="entry name" value="Acid phosphatase PHOa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757697" description="Acid phosphatase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="448" mass="49117" checksum="6A95464DD279291A" modified="2008-04-08" version="1">MKPSVATLLATVSLVYAQTATEKEPSLSAIESAAASIQPYSPVSNVEGVAFNRFFQVWLENIKDYEDAAADENMKWLASQGILLTNFYAVTHPSEPNYCAAVGGDTFGMDNDNFNQIPANVSTVADLLDTKNIAWGEYQEHLPYPGFQGFNYSNQETYVNDYVRKHNPLVLYDSVTKNSTRLRQIKNFTSFEDDLANKKLPQWAFITPNMTNDAHDTNITFGAKWERSWIAPLLNNSYFMNDTLILLTFDEDGTYSKSNKIFSVLLGGAIPDELKGTQDDTFYTHYSVIASVSANWGLPSLGRWDCGANILEIVANKTGYVNYDVDTTNLRLNETYPGPMSAGEYSKYSPVWPNALTRGDCSAGHGILDIVKETYANTEPTYNYSSPFPYDTASNYNTKVTATKKNVTGTHRSSSSSSPSASSNAAVSAVAPAAGVSGLLLGLALNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN40</accession>
    <name>B0XN40_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_014490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014490"/>
    <dbReference type="HOGENOM" id="CLU_058651_0_0_1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000013">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="336" mass="37055" checksum="DAC1D99BF8BD9A48" modified="2008-04-08" version="1">MSRQPKLCPKSHIPGYPNAFCDLAALASLSQSDPRSGSGEEKPEQRLFRVKRKHVLKACDRCRVKKTKCDGKQPCNRCSAHNHPCLFRERKATQTKVYSRGFVEMLESHHSLVVKALQKLYKLSLNKEGFPGEPLPEASDGYPLTHAILDRLGLIKQAEENPEDSNEDSEDLQYLRLLSTSAECSATTDPSPEPATPPEPSSSNCSPVDLSPVGTGWKWNFPSIQTVRSEHYHSYLNQDFAGLPPSRTDDLAGDTACLSTAATVLGHNHPYLYYLDTCNADAKESLGSCVTAGPGFQQPATATEMSVNMLGGFNVHLQEQQPIHPPLVPDWSYPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNZ8</accession>
    <name>B0XNZ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sphinganine hydroxylase Sur2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_016240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016240"/>
    <dbReference type="HOGENOM" id="CLU_043293_0_1_1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="PhylomeDB" id="B0XNZ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="9">
        <location>
            <begin position="206"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="426" mass="48345" checksum="9D084A36FC76B6D8" modified="2008-04-08" version="1">MAVNASIEYDYPPLPSYTLTPRPPLLAPIPDNILALILPIVAYWGLSMVYHVIDVYDLFPQYRLHTPAEVLKRNKVSRWDVVRDVILQQVIQTLAGMVVGYFDDVEYIGREEYDVAMWARRLRLAQKAIPRLLAVFGVDAFGLSRSLSQNGHAILAGVLAGGQYPGVTQSFVMDSGIEAVVPAFTNWELSMASLIYWYFIPAVQFTVGVFIVDTWQYFLHRAMHLNRWLYVTFHSRHHRLYVPYAFGALYNHPVEGFLLDTAGAGIGFLVTRMTNRQAMWFFTCSTIKTVDDHCGYAFPWDPLQHFTNNNAAYHDIHHQSWGIKTNFSQPFFTFWDRLFNTKWEGDVKLRYERSREAAQKQVDQDASSAAASSNEENSYEGPVVSPDAPADSNARARLRRKTVTLSPHVDSLKGVNHGVTSSVLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP31</accession>
    <name>B0XP31_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_005740</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005740"/>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="B0XP31"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="111"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="211"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP55874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="308" mass="33321" checksum="9C09D186508EC92E" modified="2008-04-08" version="1">MASFYRAFTDSFAVGGVSAAVSKTAAAPIERIKLLVQNQDEMIRAGRLDRKYNGIIDCFRRTAQAEGVMSLWRGNTANVIRYFPTQALNFAFRDTYKSMFAYKKDRDGYAKWMMGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKGGGERQFNGLIDVYRKTLASDGIAGLYRGFGPSVLGIVVYRGLYFGMYDSIKPVVLVGSLEGSFLASFLLGWTVTTGAGIASYPLDTIRRRMMMTSGEAVKYKSSLDAARQIIAKEGVKSLFKGAGANILRGVAGAGVLSIYDQVQLILFGKKFKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPA7</accession>
    <name>B0XPA7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_016670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016670"/>
    <dbReference type="HOGENOM" id="CLU_029043_1_0_1"/>
    <dbReference type="OrthoDB" id="5412502at2759"/>
    <dbReference type="PhylomeDB" id="B0XPA7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="394" mass="44495" checksum="EC911F32A612BF01" modified="2008-04-08" version="1">MPWFPPAGQSAQDGWRFDIVSLLAIIGESTLERHVQVITASSYAWLPRLLPAPQTVLKTERPARLPSIKDVVITGVYSGLHLTELNFFADVIHDVATLRQYEFRVYDIHYAHKESKEAEELRSRPQVLTDGVAEPVYIPVKRFCALNVVNWISVVMTLGLFIWAGLIHDGLAMIALVTMSLSTSLACLSSEWYPVLSHRPTDAKVPPGDIVIATRHGAFVVVRCDEEITRELYGGTETCRYVFGDTWHRVLLGTSTVLLMASVILFNNCGWTMQAAIGSAYIILNILYWAVPLMMHRKSTWDMSRYEIKRAAPKARPTKRTPSYTETLWYAIRETGRIEWVQNSKLAPSTDAWRKWLQEALTNCYDGSTWDPVDAKDRFMREAAESVSPATKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPL5</accession>
    <name>B0XPL5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_006810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006810"/>
    <dbReference type="HOGENOM" id="CLU_102601_1_1_1"/>
    <dbReference type="OrthoDB" id="5275361at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="138" mass="15113" checksum="B158D5A68C81986B" modified="2008-04-08" version="1">MPGKRSKAVEADNSQIEEGFTGLTEGVGHLILEHDYPRRRFSTTAGTEPASVAVDVNAVLESVTAEELRVGAWVNVVGYVRSWDSDGGDADALRKLRMSSPVYVEAVIVFSAGVIELGEYERVLREALEVVRRIPRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPY3</accession>
    <name>B0XPY3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_007980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007980"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_3_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="B0XPY3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP56097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="296" mass="32753" checksum="70D3EB7EEC23D723" modified="2008-04-08" version="1">MAQSSTEIPSVELNDGVKIPILGYGTGTAWFKKGGATGIDRELVESIKTAIKLGYHHLDGAEVYGTEPEIGLAIKESGVPREQLFVTTKVITNIADIPRAIDASLEKLQLSYVDLYLIHSPFFAKSDNELQEAWAAMEKVKAAGKARSIGVSNFLQSHLEAILKSAKVTPSINQIEYHPYIQHGGLVQFQGDKGIKTASYGPLTPITRAKDGPLGEVLQTLAYKYGVSEGEILLRWSIDRGDVSITTSSKESRLSSYLRALRFRLTPKELDEISAIGRQKHYRAFWRDKFADDDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ32</accession>
    <name>B0XQ32_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_008520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008520"/>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_1"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ32"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="192" mass="21843" checksum="3206771522DC484C" modified="2008-04-08" version="1">MRYIYSEERLPIPENVKVHIRSRVVTVEGPRGKLVKDLSHIAVTFGRPEKNVISIEMHHGARKGVATLRTVRTLINNLIIGVTRGFKYKMRYVYAHFPINVNIEKNSETGQYEVEIRNFLGEKIVRRVTAQPGVEVAISSNVKDELQLTGNSLEAVSQSAADIQQICRVRNKDIRKFLDGLYVSERGNIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ64</accession>
    <name>B0XQ64_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_008870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ64"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008870"/>
    <dbReference type="HOGENOM" id="CLU_134520_1_0_1"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ64"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP56178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="121" mass="14100" checksum="108082964E86D5F5" modified="2008-04-08" version="1">MGFFAGFLSGFALTSTVLYLTIQVHRANRVEQSHIIREQTRSLNWIASPIGAYDRRLAPKDPPQLDLERSQQQPTLKDFLKHRWNEEVETLARRAYESRWEDARDAAIAGWKAAMRLMKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQP9</accession>
    <name>B0XQP9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_010730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010730"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="PhylomeDB" id="B0XQP9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="280" mass="31825" checksum="D616AE4C47086C26" modified="2008-04-08" version="1">MEAPIKPTAAHRPLPKTQIKDEFSGTEGVYLLPHHQEEIKRLQRQHFFIKAATEDKLTSVELPKGARVLDSGCADVKSTIIGARPRKRLKVASAGTWLADLAGTDRPDLDLYGVDLGMALFRPDPRLKLRAHDVRQPFPESWGWKDSFDLVHQRLLVWGIREDEWPRVLANLATVVKPGGVLQLVEAEWVLSSYSDEQVHQKKLAKVQEWSTRSSGMDVHIWKKFPDLLLPLGFVDMKVETFNLGYGATSTRPEDRIWTAELLPQSFRHLARKIPGMYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQR1</accession>
    <name>B0XQR1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell wall biogenesis protein phosphatase Ssd1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_010850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0XQR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010850"/>
    <dbReference type="HOGENOM" id="CLU_002333_0_3_1"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="PhylomeDB" id="B0XQR1"/>
    <dbReference type="PHI-base" id="PHI:9183"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903450">
        <property type="term" value="P:regulation of G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="7">
        <location>
            <begin position="759"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1204"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1226"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1277"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1378" mass="152341" checksum="764778E90DCDA276" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR22</accession>
    <name>B0XR22_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_011970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011970"/>
    <dbReference type="HOGENOM" id="CLU_2291063_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="101" mass="11956" checksum="8888B13BDCA2D60D" modified="2008-04-08" version="1">MEKISKEREGEWDWGERVAKAGCAVSRLLVWTKERYFGANYTLYQGLYFVWVLSPRYEAPMQNTEPEQWILGKGLEDWNGMVEKRGAAMTDHWRLDRPPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR27</accession>
    <name>B0XR27_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane-tethered transcription factor (SPT23), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_012020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012020"/>
    <dbReference type="HOGENOM" id="CLU_002768_1_0_1"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="PhylomeDB" id="B0XR27"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1359"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="7">
        <location>
            <begin position="323"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="817"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="719"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1257"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1139"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1407" mass="153066" checksum="337D0243974482FF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR67</accession>
    <name>B0XR67_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_012290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012290"/>
    <dbReference type="HOGENOM" id="CLU_006331_0_0_1"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="PhylomeDB" id="B0XR67"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="170"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="589"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="947" mass="107333" checksum="B0200B74FD5F9917" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRN3</accession>
    <name>B0XRN3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_013280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013280"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="PhylomeDB" id="B0XRN3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="75"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="607" mass="67457" checksum="9D6883F4C16B9F5B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS15</accession>
    <name>B0XS15_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_025580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS15"/>
    <dbReference type="HOGENOM" id="CLU_058466_0_0_1"/>
    <dbReference type="OrthoDB" id="5374349at2759"/>
    <dbReference type="PhylomeDB" id="B0XS15"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34938" checksum="3B2731DF7EC55EEE" modified="2008-04-08" version="1">MPSSKRVRPPIRLRILIGIAPYSFHPEHLDRKKRKNEELASKILGKNRKTVAAGAGAGIKAQKTKPGSLASRIGVVKPAPVRAADSQPKRASKRRPDEERLLSALNPANGQSTVRDNPVGITIRGAGSGSFVVIGSNFAPGTTAADIQSAIEPLSGQILSCWITSQHPTVTAEITYADKWAAEKAIANFHNQRADGRILSMRFKHITPEPTPSQHVQNPQSSFSNLREQADRERRLNRKAEPTVQDGRYGFAEGDDQLLSHGDSRGNGRSNRRNARGNRAYGRAGRQTNQNTQETGLYSDQMMVDPPTQNSSHRGGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSA9</accession>
    <name>B0XSA9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_026540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026540"/>
    <dbReference type="HOGENOM" id="CLU_015101_4_0_1"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="B0XSA9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF85">
        <property type="entry name" value="A, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760124" evidence="2">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="342" mass="38499" checksum="55D893112E2EBE03" modified="2008-04-08" version="1">MIAITRNLALATLAFGAAALPPQLSCKNAFDWDATRYLLTFGDSYTYVQGTHGHQNYSFIGDQLNFEYDWRTLLSNKIVQNQTATAEGGPNWVEFLTNCGVKKGLTSPLSCEKQLWDFAFAGADISIEYTPLHHNYTVSLVNQVIQYEQYGHPVLKNIIHPSRTLVAIWIGINDINDSAKYAVHFPTLYNRMMTTLFTSVQTLYNLGYRSYLFMNLPPLDRTPANQARSNPSPNATQITWFNNALSQHAMSFARAHPNATVQVFDAHTALSNMMDHPAQYGIVNTTNFCAGYNQPDIETNYLAYGCPTPLDTYFWFNSGHLTSHVHKELAEILEAQLKSCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSQ3</accession>
    <name>B0XSQ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solid-state culture specific protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_017210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017210"/>
    <dbReference type="HOGENOM" id="CLU_042176_1_0_1"/>
    <dbReference type="OrthoDB" id="5946236at2759"/>
    <dbReference type="PhylomeDB" id="B0XSQ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053269">
        <property type="entry name" value="Asp-Met_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018:SF1">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="176"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="463" mass="51657" checksum="CDB015463BB0D994" modified="2008-04-08" version="1">MYSSTPSPITLDYTLHDLYIASQEDGLNTVLIYYPLQFGHNHEGKSAKFAYGYKVEEEDEFATSLTMAANLVPQRYAFSAGRMPLVILDIITQRRLAGGSEGDSRATDSMPAHHLDIYQTFAQLHPDQRPIVSFAEDSDRIQLGSDARVAVLLPTDCLSHLPHLICPETHYEILSKRGLAVSGLPTPPSRVIDTILGDSEDPTLLTIEIARMTAPIDQHQIPFIVKLPQSISGMGTFAVTSETDRTRIKAMLTSQLGAMLRQLNQTNRHLHPCSLVLQDFVDGPVVALSLFVTKTGKPFFVACCEQLFNHHSHWIGGRISYRRQDWYRKTFCALMGKVAAFLHRKGYHGPAGVDIVIDQRSGEQLVIDLNVRVTGTFHLGPLMGHFTRRGLFEAAMTSGHLFCTRDEFEEIFLEELRQGSMIVSGFVHNESQSKSHAAITVGARDHDSLQEYLERVRAVGLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSU6</accession>
    <name>B0XSU6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_017650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017650"/>
    <dbReference type="HOGENOM" id="CLU_074611_0_0_1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="PhylomeDB" id="B0XSU6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="237" mass="26396" checksum="1225C64E7ED6A1BF" modified="2008-04-08" version="1">MSAPKITLYTNHRCPWAHRAHIALKELGLDYEEVIIDLNTPREPWYLEINPRGLVPAISYNGTIITESAIVAQFLADAHPSHLLPPSNSVEGALQRARIAFFVDTFFSKVAPHFLASQRATSDQDRVAAGEAIVAAIEKELEPILASQKGPGPFFGGREKLTLAEVLIGSFLLRLLSFHKPEHGLLREDLPQLLEKRTPAFTKWANATVEQESVNFIWDEKSVVELTKKKIASLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT71</accession>
    <name>B0XT71_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C-4 methylsterol oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_018240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018240"/>
    <dbReference type="HOGENOM" id="CLU_047036_1_0_1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="PhylomeDB" id="B0XT71"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="8">
        <location>
            <begin position="113"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="245" mass="28370" checksum="CFC0C14DBDFA5F90" modified="2008-04-08" version="1">MESKWKDIVASYPPQAIEFVGTVLVQVISFWLPSLCYLSLDALFPSFSQRHKLQPALRQPGRRDIWQCFVVVVQNSVLSMGLHLFQIFVLQRGTSAFRIQASLPPLAEFLRDFILCILLREALFYYSHRFLHSPFFYARIHKRHHKFTAPIALAAQYAHPIEHIVANSLPISLPPQILGSHILTFWAFLAYELANTATVHSGYDFFKNKAKMHDLHHEKFNLNYGSIGLLDWLHGTDKLEKKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT76</accession>
    <name>B0XT76_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AFUB_018290</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT76"/>
    <dbReference type="SMR" id="B0XT76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018290"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PhylomeDB" id="B0XT76"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="110"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="311"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP53785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="489" mass="53947" checksum="008D96BC8C93E59F" modified="2008-04-08" version="1">MASEQPVEAAPTGGSLADRITKPDESNTSETPAPIGDQTDGAPAQLGGSDLHEPEYNVEVKLSDLQADPNNPLYSVKNFEDLGLDPRILKGLSSMNFRKPSKIQERALPLLLNNPPKNLVGQSQSGTGKTAAFVLNALSRVDLSTEQMQKTPQALILAPTRELARQILGVVQVMGQFVDGLIIGAAVPTDRDSRPKRLECSIVVGTPGTVGDMIKRRTFIPNKLKVLVLDEADNMLDQQGLGDQCIRVKALLPRDIQVVLFSATFPEHVHQYASKFAPNANEITLQHEELTVEGIKQLYLDCADGEDKYRTLVQLYGLLTVGSSIIFVQTRAAAQEIERRMTAEGHTVVSLTGERDPSVRDAIIDQFRRGEAKVLIATNVLARGIDVSTVSMVINYDIPELHQPNVPGRQADFQTYLHRIGRTGRFGRVGVSISFVSNREEWEMLNQIQTYFNCEIQRVDTKDWDEVEDIIKKTIKNSRANPKFAGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTF4</accession>
    <name>B0XTF4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_029220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029220"/>
    <dbReference type="HOGENOM" id="CLU_054069_0_0_1"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PhylomeDB" id="B0XTF4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="2">
        <location>
            <begin position="46"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="313" mass="34525" checksum="EA9AF32C5CD56108" modified="2008-04-08" version="1">MSTSRRPPPAYTAAKDSAVYGTSQVYRKISESASSESGRILETSFTIRPCSGQAWVVPAGHICRLTTPKGPQVGDLNIWNANNPRERLWAARTRQIHASHVSVGDRLWSNLPYLRPLVTITGDSLNGGQLHEVLEVNGQRKEGVGFGTSKWGGRVHDLLGTRCDPYVNLLMGGETFDFHCHSNLTRAVMPYGLTELDVHDVLNVFQVTGLDEQGKYFMETSPAKPGEYFEFFAEVDVLCALSACPGGDLSQWGWEEKGEKMGATTRPLGVEVYKLADPKILDGWKQPESPNYRGLHGLQMPPRETDDSGYVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTI3</accession>
    <name>B0XTI3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_018680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018680"/>
    <dbReference type="HOGENOM" id="CLU_050739_1_0_1"/>
    <dbReference type="OrthoDB" id="4524870at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760161" evidence="1">
        <location>
            <begin position="32"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="246" mass="26427" checksum="62A571F23AF5B68A" modified="2008-04-08" version="1">MSLQLGSASVFRPGWALSILVVLAALPSAIAQFCTFWDGGCVDPLAQTAINFDFPPLFLDDLTLYYGFDANPSGKGQEPMVKASFWLAYDPHRIDSTVITANRTSEIAFRVGNLTGTPSGSSNGCDGVWGPQCTHDLKELLKGAMYELTIKGDYTYPLQTVITFAQESEPDKTAMIQTPGFGGSPWKTWFIDNMTSSQQAEQVAVAILSRAPSSNTYSMHGKDDIMVELVCIQAPSSGGASSSQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTS3</accession>
    <name>B0XTS3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_029750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029750"/>
    <dbReference type="HOGENOM" id="CLU_001060_9_0_1"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="PhylomeDB" id="B0XTS3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="321"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="676"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1468"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1600"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1648"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1188"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1472"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1493"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1612"/>
            <end position="1621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1694" mass="184631" checksum="51D526E23D44B511" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU09</accession>
    <name>B0XU09_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1295 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_019770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019770"/>
    <dbReference type="HOGENOM" id="CLU_043418_0_1_1"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="PhylomeDB" id="B0XU09"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="369" mass="42410" checksum="667461E14B2A16E5" modified="2008-04-08" version="1">MAIPLPQVHSVVDCASFNRTVLPFLSQLTTLPAQLQVAASTKDVDSLKDIYLSTNPFISALGFTLVLWVLFAVAAEFNRNYSQVDRFWSILPSVYTVHFVAWARLWGIKNQSLDTIALITLLWGIRLTFNYWRKGGYQIGSEDYRWEIVKSHINNRFFLFLFNVTFISLIQPLLLLLVTAPTYNFILLSRLPGAEPFGLPDLAFSRLAFFFLIIEYFADQQQWNFQSAKKEYQKTARIPDQYKGQFTPEDLERGFVVSGLWSLSRHPNFVAEQAIWLTLYLWNCYRTGSYIQWTGLGILGYMLIFQSSTRLTESISAGKYPEYSEYQARVGRFIPRFSVKPKYNGSKKKTSRSKTESAGTATQEGKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU72</accession>
    <name>B0XU72_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,6-mannosyltransferase subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_030560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030560"/>
    <dbReference type="HOGENOM" id="CLU_021434_0_0_1"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="PhylomeDB" id="B0XU72"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP54995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="462" mass="53690" checksum="4EA3129B7AD3DB60" modified="2008-04-08" version="1">MSLSRSPSPHPGGGWSSPGLTPGSGTSTPRSGFLSPNSLGPSGISWAAARAKSEEVRGYPSFSTRNNGFFSRSKRKITSSLPRFRMNGSARYGYVDKDEYWRGQNYSGTGLRFGFARGLMRRRRSRAILALIVLSLGYLFFWTAIVQSYRRSSFGGGRKFVIILPSNVEGGVMEWKGAREWAIERNSISNKEEYAKRWGYELEIVNMLAKKRYSHEWRESWEKVDIIRDAMRKYPNAEWFWWLDLNTWIMEYSYSLQDQIFDRLGDLTYRDINLYNPLNISHPPTAPYLDELSRSAEGDGNPSSIDLLLSQDCGGFNLGSFFIKRSLWSDRLLDLWWDPVMYEQKHMDWEHKEQDALEYLYQSQPWIRSNVAFTPQRYINSFPPGACGEGDDPDVHYSEKDRDFLVNMAGCQFGRDCWGEMYQFRELSKKLNRTRWQRLKDGLGELYSRLLPKEDKSQEQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUA6</accession>
    <name>B0XUA6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoside transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_020060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020060"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="PhylomeDB" id="B0XUA6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP53960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="524" mass="57369" checksum="777050E82FFF1EE0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUJ3</accession>
    <name>B0XUJ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorbitol/xylulose reductase Sou1-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_031090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUJ3"/>
    <dbReference type="Allergome" id="9530">
        <property type="allergen name" value="Asp f SXR"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031090"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="PhylomeDB" id="B0XUJ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="266" mass="28220" checksum="6024E64EB47CA432" modified="2008-04-08" version="1">MPIPVPAASSLLDLLSLKGKTVVVTGASGPRGMGIEAARGCAEMGANIALTYASRPEGGEKNAAEIAKTYGVKAKAYKCNVGDWESVQKLVADVIAEFGQIDAFIANAGRTASAGILDGSVNDWAEVIQTDLTGTFYCAKAVGPHFKERGKGSFVITSSMSGHIANYPQEQTSYNVAKAGCIHFAKSLANEWRDFARVNSISPGYIDTGLSDFVDKKTQDLWLSMIPMGRNGDAKELKGAYVYLCSDASSYMTGTDLLIDGGYCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV42</accession>
    <name>B0XV42_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_021580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021580"/>
    <dbReference type="HOGENOM" id="CLU_018249_2_1_1"/>
    <dbReference type="OrthoDB" id="5377172at2759"/>
    <dbReference type="PhylomeDB" id="B0XV42"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758373" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55111" checksum="255C5F8307494A96" modified="2008-04-08" version="1">MPGRGLLRLTAGWALLSLCVAEDTWPYMTLQTAPYQPPQIQVTKSGTTDPGYLFVGPRGNKPEGTAALIYDEDGHLVYQGPDEVTANFRVQRLFNQDVITFWAGNMTDLGFGYGTVHILDNTYREIYTVTLQGNFVTPDHSVPESFIDLHESHISDRNTLLVTAYNVTQQSLTSIGGTPEDYMLDSLFFEIDIATNEIVHSWSALEHVDQIALTDSKQGIDIDHGTHEQPWDAYHINSVELFDEGYLVSLRHYWSGYYVHGNGTVMWQFSGELGKGDFQLDPAGVFSWQHDMRIYNKTDTGMILSLFNNANTPTETVAASTGLSYAVDLVNRTAKTLRTLSDSKDVIHSVSQGNYQQLSASGHVVLGYGSIAKLKEFDANNKPVLTAQFGTDNEVASYRGYKCAWKATPFWAPAIVVRRVSDDSAQVFMSWNGATEYDNWAVMAADAPDSVRTSIVATFKRTGFETSGTVRGLKTRYLQVVARRGDIPLGMSPIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVB8</accession>
    <name>B0XVB8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_032570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVB8"/>
    <dbReference type="HOGENOM" id="CLU_031002_0_1_1"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="PhylomeDB" id="B0XVB8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46953" checksum="F9D41FEEF5150A06" modified="2008-04-08" version="1">MESEKEFDLVLVGPTGYTGRLCAEHIVKNLPTNLKWALAGRSVQKIEVIAKELKTLNPDRAAPALTHPQRFWLYSSIGKNWNPSSRGLKSSSIALAHTTFTALLLLKHVLIMELIMWTPLRNPLGSTGETPWIREIIEKYHDVAKSNGAIIIPSVGVESAPADILAWSVVKRVREDLSSDTKEVIGAIEEMKSSGPSGGTLITVLTIFDSLSFSDILKSTDPFALAASAPPKNVPSEPLVDKILGVRSVRDLGTLTTSPSAMADITIVHRSSTLMPEFYGPLFYFRQFVKVRNALVGIIFHYAFIIGLCLLTLPPVRALVRQFVYAAGQGPRKEDSVNDRVEYRAVATADQKTAAPQRVFGKFKYEGSMYALTGLLLAEAAMVILEETERVKKVSRCGIVTPATLGQPFVDRLEKVGCHLETQVFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVE4</accession>
    <name>B0XVE4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_021960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021960"/>
    <dbReference type="HOGENOM" id="CLU_081631_1_0_1"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25217" checksum="67DF4B76C32BD980" modified="2008-04-08" version="1">MVVPVTEFVIFKLKSSVKPEDHSNEEGASLCKIFSATKQQSGHQSSAWGRTVEDENVVVWAVVWEDSHGKCQADLLAPYLEPNSKVLSFYTTLNPSPSETETFTTNQVTELATLTFPSSLNPEEHKKLNSDLINLRVALTEKLDEKSRSKSWSMAQVHRPGTFQHPKSPSGEAFVYLLVVGWESVDAHMAARETKEFEESIKPIREKMLPALEGLGMKHVSFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVM1</accession>
    <name>B0XVM1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_032930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032930"/>
    <dbReference type="HOGENOM" id="CLU_1721915_0_0_1"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16592" checksum="9EB5D52020492913" modified="2008-04-08" version="1">MPQDLSAIPLDILPELCENLSVGKLTKKDDIAKPQSDFVLGYVAANSSKLLGYRAPNGRSVLHYIAAAGNEALLAVSQKEGADISSACCHGADWTIHDRHGNTTLHAAAANWDCEYDAVVRHIIQVARERRETKETIKLLLDNGCTLMWPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVR5</accession>
    <name>B0XVR5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_033380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033380"/>
    <dbReference type="HOGENOM" id="CLU_3086801_0_0_1"/>
    <dbReference type="OrthoDB" id="3932329at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="52" mass="5633" checksum="262AAC0879A0FDDD" modified="2008-04-08" version="1">MSAWGDQKVYEYEMAPSPIPGLTQEILFIPATACTVLARTDWIVSQTGGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVY2</accession>
    <name>B0XVY2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_023210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023210"/>
    <dbReference type="HOGENOM" id="CLU_015361_0_0_1"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="PhylomeDB" id="B0XVY2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="295"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="651" mass="71472" checksum="09D8C2717608C685" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW20</accession>
    <name>B0XW20_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_023280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023280"/>
    <dbReference type="HOGENOM" id="CLU_028900_1_0_1"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="PhylomeDB" id="B0XW20"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001408">
        <property type="entry name" value="NASP-like protein sim3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="311"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP54272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="50225" checksum="1D7A68FDDD718352" modified="2008-04-08" version="1">MAELNSAKADPIKLKSTADAKRVQLEDLIARAVAKDAIKDFNAAAELYSQATELQAKLNGELSLDNADLLFSYGKALYNVAVSKSDVLGSKVAGEPQAQTNDLPPSGSKSFAHVPGESIIKNAIASGVAKQEHSKDSKSSSGKTLNQAFFQFSGDENFDDSDSEAEEGDGGADGADDDDDDFANAFEVLDLARILYHKKLAAVEESCEEGKSAGLLPDVKYIKERLADTYDLQAEISLEGERFTDAVADLRTALDLRQSLFSMEDPSLAECHYKLSLALEFASVNNSSEGTTEGDSGRRGKVDEAMREEAATQMEKAIESCRARMAQEQKKLDVSDALDEDRETALRRKIANVKEIIEDMEQRLLDLRRPPVSVEQQNKESDTMLRGILGQIVGQPAVEQQARLEAITKDAKDLSALVKRKPAGIQRPPRSESTEKRSAPEQVEDEFNTKKARTESAENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX19</accession>
    <name>B0XX19_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter Liz1/Seo1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_047420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047420"/>
    <dbReference type="HOGENOM" id="CLU_1156140_0_0_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="PhylomeDB" id="B0XX19"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="240" mass="26839" checksum="F10DB759DC1E3F37" modified="2008-04-08" version="1">MFQQWCCRVAAYISTIPQTLNQPQVLRRPDQRLPDYHWSSSSSDHSDLCLDIGLHSRRQPLATHHLRRGKHRSPTPTPLSLTIQIINIISYTSLAIWDISTGWKWTCYIIAGAGYGLSGLLMAYVFPFSVGVSQTEDNRWAHEICAEDNEERALVVGSMNEMAYVFQAWLPQIVWRQVEAPEYRKGFVTVTVLSGILILATFVTVGLEKRERAQKLSGATEGDSEDSLAGVDSEGDAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX24</accession>
    <name>B0XX24_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_047470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047470"/>
    <dbReference type="HOGENOM" id="CLU_027371_0_0_1"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="PhylomeDB" id="B0XX24"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="474" mass="53089" checksum="E7C8E2AB58EEAA24" modified="2008-04-08" version="1">MDMHVPARSGGLSWSPDLKASNTTELQHRQKFQSEEQAKIMTNQRQKRPHTKSRWGCYNCRARRVKCQETKPACENCMYRDLECVYPSKVREWVGAGKQTASRGDALVASSPSGKPVPRSQGLAVSPFSRDDLRFFHHFLIAARPHLPFGSEETWATEVPRYAHEYPHLMHAILALGATHYSLVSPNGSEYSSTALVHRGKALKELSAAIGKGPECTTTDMDVILATCYALVFQAYHMHDGLVDFAVMVRGCGVITNCIVDKYQTSQLFHLQTEEEAAEVALSLADEPVSSPLLVDSLLAAIDRLQPLFQSAIHHRFFRALRETLAGLAISQRAAFVRLTRIYAVWYKADNREFLTFIAPANHVSRALFMYFLVIELVMLPVYIRLRELSGTTLITTDLTVRQWADAIYRELPSSIRELVELPMEIIAADENTARSTRGTRSDSVFPNLHAQFFDMETAAWLGCAKPGGVGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY78</accession>
    <name>B0XY78_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable NAD(P)H-dependent D-xylose reductase xyl1</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_039950</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039950"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="B0XY78"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="13">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP52824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="324" mass="36294" checksum="50F19E1F75E66370" modified="2008-04-08" version="1">MALPTSYPLKTGDSIPAIGLGTWQSKPNEVKEAVCTALKAGYRHIDAAAVYGNEKEVGEGIKLSGVPREEIFITSKLWNTHHEPEHVEGALDQTLRDLQVDYINLYLIHWPVSFRYSTSTNQPVDAETGLVDVIDVPLKDTWAAMEKLVDKGKVRSIGVSNFTRQRIEELMTTARIPPAVNQIEAHPYLQQRDLLEWSKQQGIVITAYSPLGNNIYNIPRAVDDPTVIQVAKELGKTPAQVLISWAIQRGTSVVPKSVTAERIKSNLEVFVLPEHAFERIQALDRHLRMNFPARLGVDIFGEVGEESVRQSALEWARQQKMQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYH6</accession>
    <name>B0XYH6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AFUB_040950</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYH6"/>
    <dbReference type="SMR" id="B0XYH6"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PhylomeDB" id="B0XYH6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 22" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP52922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="406" mass="45779" checksum="070B8F222C96BEE2" modified="2008-04-08" version="1">MASNDKGLEEIPEGQIESNYDEITDSFDAMDLKPELLRGVYAYGFERPSAIQQRAILPIIKGNDVIAQAQSGTGKTATFSISALQKLDPNVKGCQALILAPTRELAQQIQKVVVAIGDFMNIECHACIGGTNVREDMKALQEGPQVVVGTPGRVQDMIQRRVLRTDNLKMFILDEADEMLSRGFTEQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTKFMRDPVRILVKKQELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMEQAQRDVIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYSTQIEEMPMNVAGKFNHVDISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYW4</accession>
    <name>B0XYW4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 transcription factor (Gal4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_042310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042310"/>
    <dbReference type="HOGENOM" id="CLU_1348647_0_0_1"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="203" mass="23604" checksum="27D458159CF76677" modified="2008-04-08" version="1">MEDWYNSLPHYFKQPITTPEPDNFALVRNRLMWRHWNLRILLYRPILLRWASRRWTPTPGSPLESEDPLETECRMLCLRNARWTISSISDFVNNHICTRLGAWYMLYFLFQAGLIPIILLMTDPTSTDAPAWLQDVETTKKLLTHPSLSNNRLATRCLEVVNRLCSPTYTSSVSDGSTPIQPPMLMQFSDQLLNDPMFGTVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZS2</accession>
    <name>B0XZS2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_045050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045050"/>
    <dbReference type="HOGENOM" id="CLU_091061_0_0_1"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="216" mass="23777" checksum="2D68F1286BD33E4C" modified="2008-04-08" version="1">MGSATNNPVDFGGNYAILNLDWMSLLIKAVENTPEGQAMIASCSRWNVAVHQKSPRPLTVFSTLSFSPGQPEVQPNSPFADLLRPYGEFAQGTPPVEIDERFHLDEKDLVLHKTRWSATSGNALEQILKAQGIKTVVISGLSLSGVVMSTIYRLFDLDYDIYVIRDNVVELPPAQNTAFSNVLLDMLLPKMGLKVISLEDALEALSRSEKSAERTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0W2</accession>
    <name>B0Y0W2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleosome remodeling complex ATPase subunit (Snf2h), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_058740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058740"/>
    <dbReference type="HOGENOM" id="CLU_000315_32_0_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0W2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000115">
        <property type="entry name" value="Nucleosome remodeling complex ATPase subunit (Snf2h)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003221">
        <property type="entry name" value="Nucleosome remodeling complex ATPase subunit (Snf2h)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="181"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="535"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="986" mass="110809" checksum="4EFB7067C412CA5A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y154</accession>
    <name>B0Y154_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_048730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y154"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048730"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B0Y154"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000989">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="198"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="685" mass="75915" checksum="5BD592D31E0323C5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1W9</accession>
    <name>B0Y1W9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_050110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050110"/>
    <dbReference type="HOGENOM" id="CLU_043690_0_0_1"/>
    <dbReference type="OrthoDB" id="414322at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="337" mass="38054" checksum="AACBB1918CC7D150" modified="2008-04-08" version="1">MPSISDRLTVIITTSPAPSNPATDLIASVLQSFQQHCAGLTDARVVVVFDTFARVTSQPRLKKGHASPELAESYALYKRNIKALILQTYRHEQDGQGQAASEKSHAEAEFGFDGRVELLITRTRSRKITFIEPVARLGFGLAVRSALRVVETPYVWVQQHDWALEADIPLEPLLEIMQGSEADDAVPVKYVSFPSVRMKRYAVSPHVTDHAALRELTTSLKRDFVVRSPSRPERKIALTPLFFWFDKPHVASTAHYLARVFPTPLAMRRGEFIEDKIGQRARAQMKEGQWAKWATWLYYPDEGDLLCLRHLMGRTWRGFGGPINVKDGFHIATDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y229</accession>
    <name>B0Y229_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_050710</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y229"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050710"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="PhylomeDB" id="B0Y229"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="38"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP51069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="371" mass="40129" checksum="7F80D42824DF144A" modified="2008-04-08" version="1">MFRQSVRRFGTTALRAVEASTAYHERVSRAQGVVNGLTEAIGNTPLIRLKRLSEETGRNIFGKAEFQNPGGSVKDRAALFVVKDAEEKGLLKPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPQNYNHQARRHAESLENAVWTNQFDNTANRQAHIETTGPEIWAQTDGKVDAFTCATGTGGTLAGITRYLKTASDGRVKCFLADPPGSVLHSYIQSGGNLIERSGSSITEGIGQGRVTDNLKPDIDLLDGSLTISDEKSIEMVYRCLDEEGLYLGASSALNVVAAKEVAEQLPKGSNVVTILCDGAYRYADRLFSNTWLQSKGLRSSIPKHLEKYVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y235</accession>
    <name>B0Y235_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_061110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y235"/>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="PhylomeDB" id="B0Y235"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="213" mass="24251" checksum="51C9CAAEA966A1F6" modified="2008-04-08" version="1">MTPAERLRKHQRALDRTQRELDRERIKLENQEKKLIQDIKKSAKNGQIGACKIQAKDLVRTRRYIQKFYQMRTQLQAISLRIQTVRSNEQMMQSMKGATMLLGSMNRQMNLPALQRIAMEFERENDIMDQRQEMMDDAIDEATGLEGEEEEGEDIVKEVLDEIGVDLSQALGETPSDIQKTSVGETRVAQAVGAGGGTASDDDLQARLDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y241</accession>
    <name>B0Y241_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_061170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y241"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061170"/>
    <dbReference type="HOGENOM" id="CLU_071690_0_0_1"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="PhylomeDB" id="B0Y241"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="247" mass="27801" checksum="A3EAD88525B9D727" modified="2008-04-08" version="1">MPRSKRARIVHESKVTKKSHKEQTRRLYANIRECVEKYDHLFVFSVDNMRNTYLKDVRTEFADSRLFFGKTKVMAVALGHNPENEAAPNLHKLSPYLTGAVGLLFTSRDPESVLSYFDAFRPLDFARAGTVSTRSFSIPNGLVYSRGGEIPASEDEPVSHTIEPELRKLGVPTRLVKGKVMLELTDGQEGYPVCKEGEVLDSRQTTLLKMFGVATAEFKVDLKAQWTRSTGEVKILEKDEGMDVDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2I4</accession>
    <name>B0Y2I4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_061930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2I4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061930"/>
    <dbReference type="HOGENOM" id="CLU_1815360_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="142" mass="15916" checksum="CD298CC78E72C910" modified="2008-04-08" version="1">MIPTEGGVWWSDGGWTICSRHVLYEIIRIPLSRKQHKHYTHRLPDTDSPALRERWTGHRTPFPSMSAASPPRLCLPYAKASGLNRLVWTLDSRRAVTETNQTRLEAAGGRACQGARYGNDIKLQLPSHHCFSCSCNQSTCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y311</accession>
    <name>B0Y311_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-ketosteroid-delta-1-dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_052560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y311"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052560"/>
    <dbReference type="HOGENOM" id="CLU_023808_3_1_1"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="PhylomeDB" id="B0Y311"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="546" mass="58588" checksum="FF00F974645FB1F9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3S4</accession>
    <name>B0Y3S4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear migration protein (ApsA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_055240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055240"/>
    <dbReference type="HOGENOM" id="CLU_001023_0_0_1"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3S4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1339"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1477"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1617"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1482"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1548"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1579"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1639" mass="179962" checksum="43D64391CB236B82" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y416</accession>
    <name>B0Y416_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_056180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y416"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056180"/>
    <dbReference type="HOGENOM" id="CLU_079951_2_0_1"/>
    <dbReference type="OrthoDB" id="4074965at2759"/>
    <dbReference type="PhylomeDB" id="B0Y416"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="165" mass="18535" checksum="453DA9C9456DD398" modified="2008-04-08" version="1">MPVISRLVSIVLRVAEIAFAAVVAGVIGYYLHQFSDIDAWPQARWIYTEVVAGLSILLGLIWLIPFSSGFFSWPFDVVISFAWFAAFGILVDAIHKLNCGSIWHWHFNTYSTNSCGRWKAAEAFSFLSAIVWLASALVGIWFTFRVRGANADGYYGRRRFGRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y420</accession>
    <name>B0Y420_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_056220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mitochondrial GTPase involved in assembly of the large ribosomal subunit. Plays a role in expression of the mitochondrial translational machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y420"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056220"/>
    <dbReference type="HOGENOM" id="CLU_011106_0_1_1"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="PhylomeDB" id="B0Y420"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000009">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001753">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="135"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="143"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="338" mass="37425" checksum="E15280E8CE24573C" modified="2008-04-08" version="1">MAAKFIPRQAFPSYASIPRSYYLGHHKAGLKKMQNMLSSIDYVIECRDYRVPITSINPMFEEALGKTRRLVVYTKRDLGAEPRSSAQRTAEKIIKKFDSSSAVFFVSSSSRADVSSILAHLRNDAEGPDKLVGCRVMVVGMPNVGKSTLINNLRNQGVKRAKAVQTGGQPGITRKIGTPVKIIERDNGAHVYVLDTPGVFMPYVPDAEKMLKLALCGCVKDSVISPVTLADYLLYHINLHNPGQYERWSQPTNEISPLLDSFARQTGLLAKGGIPNIDLAALHLIQKWRSGELGRFMLDDLQAEQRRIDEGIENDVGISISQALKAERMSRKQPASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4H8</accession>
    <name>B0Y4H8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G2/M-specific cyclin NimE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_069140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4H8"/>
    <dbReference type="HOGENOM" id="CLU_020695_10_2_1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4H8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="255"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="348"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="352"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="487" mass="54660" checksum="0376C3F5850FD90C" modified="2008-04-08" version="1">MNENDENGPSTRLTRAKAAALSAGDVPTTTAAAKKPLQSKKAATNSTTTGTQRRRAALGDVSNVTKTENGEAKETKKAASGKVGLTSKATMQTGGIQKLSRTNSSRTALGAKDNAKKEKPAVEGKRPGSGSGIGSTQMKRTSSQKSVQEKSLQVEEPPRKKVEVEKKTTEKKTTVEVSTAKEDAVIATEPEVAKKPEDVVDDLDTEDLDDPLMAAEYVVEIFDYLRDLELETLPNPHYIDHQPDLEWKMRGILVDWLIEVHTRFRLLPETLFLAVNIIDRFLSAEVVALDRLQLVGVAAMFIASKYEEVLSPHVANFSHVADETFTDKEILDAERHILATLEYNMSYPNPMNFLRRISKADNYDIQTRTLGKYLMEISLLDHRFMCYPQSHVAAAAMYLARLILERGAWDATLAHYAGYTEEEIDPVFRLMIDYLHRPVCHEAFFKKYASKKFLKASILTRQWAKKYHHLYIDSALTEPYNFIKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4T2</accession>
    <name>B0Y4T2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_070210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070210"/>
    <dbReference type="HOGENOM" id="CLU_045011_11_1_1"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4T2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033883">
        <property type="term" value="F:pyridoxal phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="262" mass="29350" checksum="4D4E40342B407812" modified="2008-04-08" version="1">MLASRTFYRSSSSVVSMTLLLENYAVRQRRFAPLNPALAESSDAPRLKGIVFDVDGTLCLPQNYMFSEMRKALGIDKKVDILHHIRALATAAERTAAAEKIKAIEREAMRHQQPQPGLVDLMDYLQSRGLHRALCTRNFEAPVMHLLQNHLPSHVFLPIITRETPGLLPKPDPAGILHIAREWGLENRAENLIMVGDSIDDMTAGHTAGAATVLLVNEHNTHLKDHAHTDLCIERLDELIDILENGFVGHRRDKPPTSDRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4V5</accession>
    <name>B0Y4V5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_070440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4V5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070440"/>
    <dbReference type="HOGENOM" id="CLU_1011856_0_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4V5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="275" mass="29832" checksum="07B9003270D85081" modified="2008-04-08" version="1">MNLVPHKDTITLQESTLEINKLFPQSAGCICAYPKSGILHLPDCHAAWPYKSFAPTPMSPIDKVQNYAGDIKGKVIFTTGVSPGSLGSHFAQSIAAAGPRCLNLAGRNRSKIQQAADEIKASHPSVETHLEIDLAALDSFRRAASQIHSPFLLAYLIMGKVLSAGGEESEDFQSAPWGDLHESCQPPYLLEDLDGSFEELGMTAAHDRARGDPEGWKGLDPKPLETGVSAHVYAALDLDLAGPWVDPVKPWATSALEAERLWKLSEELVGEKFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y549</accession>
    <name>B0Y549_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_071390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y549"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071390"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_8_1"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="PhylomeDB" id="B0Y549"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF159">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="295" mass="32602" checksum="87BA3E38EF39E972" modified="2008-04-08" version="1">MINIWGTTFLIGPFLGPALAGYIGAGSNWKASFGVLTAFYALSTILIFLFGYETYYARGHQCQRNSRLQSMFGIKNHSLPVGRTLAHWTKILAIYIFKFPLLLTGIATMVNFCWPIVQSASLRWAPIIGGLLGKQHPRIPDRGPDSGWRPEYRLHGVWVAIGVMACGLLTYGMTLNYHKHWIGLAFGWLMVVFGMISSTVSITAYNLEKYPDQSTVVSAIINAWRTASGFSVGYFQPSWIAKDGTAAVFGTQVAVVVAVLILTITPVIVIEGRKVKPTIGEARLRVEILLLFRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5B1</accession>
    <name>B0Y5B1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_072000</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5B1"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_6_1"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5B1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="153"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP50860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="423" mass="47866" checksum="B787A4768694CC42" modified="2008-04-08" version="1">MSNAPTASISAIVTEKNQGATSRQRLSNETQPPKMSESAHREYTPKPLPTTPARDTRSPLRTHHPLSITVLQEPDSTANEQKQLSAPVVKAQHAIQSLVSSQPAQLKNRQCALQPRQPLTVLSQASNAAVKGEQHTGKLIKQPAPRIFHLGMFEVRKALGKGKFGRVYLAHKQSTGFVCALKVLHKSKIQQGRVEKQVAHKIEIQSNLRHPNVLRLFSHFDDSKRIILILEYAGKGELYKHLQREDRFPEWKSAQYIAQMANALLYLHRKHVIHRDIKPENILVGIHGELKMSDFGWSVHAPSGRRHTQCGTLDYLPPEMVDPRKCDKPYDQKVDIWSLGVLLYEFLVGRAPFEDTPVMTQRRIAKGDMTVPSFVSPEAKDLIKKNIWASCHRSRPENFLAGSHASPLDCQALLQRRDRQDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5C1</accession>
    <name>B0Y5C1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_072100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5C1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072100"/>
    <dbReference type="HOGENOM" id="CLU_590646_0_0_1"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000067">
        <property type="entry name" value="Transferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000109">
        <property type="entry name" value="Transferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="463" mass="51852" checksum="570CA8D2F21FB1F8" modified="2008-04-08" version="1">MEGLNISNQVFDLSPLDIIPSHLYITNAFFYENKTPGPRPFMQSSLLKESLYRALQNFPILLGHVRRHRRNAMQIVVDCDNLNLPLYEEQTHPQLHFRHLKDHQFHRDVWPKDANIIDPRASPNGELLQVHVHRLAEESGVVMVVRIAHCAVDAKGFVDFMQSWGWFARNHSHPEGDSWPRLLADRRVMYEYLPPDVQPAAPRSMWHPASWLLGLLSTLVVLFLGLYKRLLGDKTPPDEIESHLFSVPPHTLDRLRYTATCIDPSSRVSDHDIITALFTLAFAHTKHLLTCRTQTVTAIVPCDFRHRIGVPSNFTGSCAIGLYVSIPGSLLQTPLTAESVARAALLSRAVVDTADKVTIQTFIRRALRAIAFVGDKVNVLYATMVSQAFSNQSRLGFYEVDFGAGGPVMVAPMAYSNTVAVICPAPGPGGDGVGVRVFLTLRPEVMRVLLAKGFLDEFTDMIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Z9</accession>
    <name>B0Y5Z9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 21">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="6 21">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 21">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 21">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">AFUB_065160</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="21">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6 21"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Z9"/>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Z9"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="15 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 21" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EDP50184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="57179" checksum="387EC9983C1B95E2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6V4</accession>
    <name>B0Y6V4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_068260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6V4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068260"/>
    <dbReference type="HOGENOM" id="CLU_030660_0_0_1"/>
    <dbReference type="OrthoDB" id="5312133at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6V4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758693" evidence="2">
        <location>
            <begin position="33"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="597" mass="66956" checksum="2F7D05108E37E200" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6X9</accession>
    <name>B0Y6X9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_068510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6X9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068510"/>
    <dbReference type="HOGENOM" id="CLU_1532172_0_0_1"/>
    <dbReference type="OrthoDB" id="10482734at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="175" mass="19808" checksum="D90DFACFBDA429FC" modified="2008-04-08" version="1">MIELNQMLTIYSPLDILHLSYRTLVFEKFKAREDQVAPPPRIRQIGSEATAVFPRQHQEKYDGAYWRRDAYTAKEWTTGTLTTCGAADVTIMLNMLKYIFQPQSVSGTGEPYLENLKVGPTIPARGGQHSFESVRFADWINCMLAYPGASPTLGEMLRTEIIKAAPEVRTREIAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y766</accession>
    <name>P20D1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable carboxypeptidase AFUB_072730</fullName>
            <ecNumber>3.4.17.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peptidase M20 domain-containing protein AFUB_072730</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_072730</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.-"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y766"/>
    <dbReference type="SMR" id="B0Y766"/>
    <dbReference type="EnsemblFungi" id="EDP49247">
        <property type="protein sequence ID" value="EDP49247"/>
        <property type="gene ID" value="AFUB_072730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072730"/>
    <dbReference type="HOGENOM" id="CLU_021802_3_0_1"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="PhylomeDB" id="B0Y766"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000411228" description="Probable carboxypeptidase AFUB_072730">
        <location>
            <begin position="17"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="440" mass="46378" checksum="022BC85527D9338C" modified="2008-04-08" version="1" precursor="true">MKPLTSLLLSAALSAAAPHPASPQAPLADIPSIVGETRTEFSQNSLDDVVNASPLLSFHRDLVSIESISGNEGAAGAFVADFLASHNFTVIKQPVTTESDARFNIFAIPESQYHSLDESHSSHSPQILLTSHIDTVPPFIPYSLHRDANDTDDRNILIAGRGTVDAKGSVAAQIFAALDILAAQPSAPLGLLFVVGEETGGDGMKAFSQSTHLNPSPSRFHTVIFGEPTELALVAGHKGMLGFEVAAHGHAAHSGYPWLGESAISAILPALARVDQLGDIPVEEGGLPASDKYGRTTVNIGRMEGGVATNVVPSKARAGVAVRLAAGTHDEAREVVLKAVRDVTGGDDRVVVNFSLEGYGPQDLDTDVPGFNITTVNYGTDVPNLQLHPRPDGKVRRYLYGPGTIHVAHGDNEALTVAQLEEAVRGYKKLIQAALDRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7A6</accession>
    <name>B0Y7A6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_073140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073140"/>
    <dbReference type="HOGENOM" id="CLU_035048_1_0_1"/>
    <dbReference type="OrthoDB" id="5338512at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758699" description="GPI transamidase component PIG-S" evidence="3">
        <location>
            <begin position="26"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="44515" checksum="A1734DC054717098" modified="2008-04-08" version="1">MARSSFTAFLVAFTTVVNTISPSYAFNSLLHRASDSCPASYEQCNNSNLPSSFCCPSTSTCVSLDNDSSAICCPSGQSCAFIEPITCDVSQQNATLHPKAVVKTIRLGDTLPKCGDSCCPFGYSCQSNSICAMSTSTTSIATNSVSSLTTTASSIPSAPSTESMTSMTSTVPTAATSSSKVTDSASSTDGVHPTIITASDPADPSAFGAASSCHGTTATMTDACPSFPTKAIIAGFFPGAAFGAILALLAMYLMRRRKNNLPPSVKIAQHTQRTSSGTLIGISDPIPSEENAYRTDFLLRRSLKRNSEGARSMLQRTGTRVKSLFGSTPKPSQMVSKQPPLPLTPPQQARMPSTESIKVYTPPGTFASTGVLRPEPYPTIVVGNGSTFTEMIDQAGSNNSKGDPSYSVDEAPRSRSKSPLRRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y838</accession>
    <name>B0Y838_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BZIP transcription factor (AP-1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_075990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y838"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075990"/>
    <dbReference type="HOGENOM" id="CLU_011807_0_0_1"/>
    <dbReference type="OrthoDB" id="5380163at2759"/>
    <dbReference type="PhylomeDB" id="B0Y838"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="157"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="615" mass="66770" checksum="B05146466C0A1FC9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8P6</accession>
    <name>B0Y8P6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_078080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8P6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078080"/>
    <dbReference type="HOGENOM" id="CLU_004184_7_4_1"/>
    <dbReference type="OrthoDB" id="4850726at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8P6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="50"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="618" mass="69916" checksum="E763CB4A703EAE79" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y965</accession>
    <name>B0Y965_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_079800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y965"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079800"/>
    <dbReference type="HOGENOM" id="CLU_092103_0_0_1"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="264" mass="29003" checksum="7CFFA3361968E585" modified="2008-04-08" version="1">MGLKLRWGEQSDAQTESATGVELTSKGFSIKTHPVGKSAYGHVLWVHAATRLPSKIPAFEVNRKTLSYNPKMPSFFRSLALYALLAGALVAQVTNAYPQPALVRSEDAAIPHDTITTEPISMVRSIEDDGDLYQRSKPLKIAKEPTKSYSCPATNNYGSNTYTSGQLKAAFVKAAQYANDGKQIGDRHYPHTFGNGEKLPFPCGRSTMEFPLDRDHPGTVYSGQSVKNLPDRIVFEFKDGKKEAKAKFCGVMRHGNNGDFVNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9G9</accession>
    <name>B0Y9G9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_081000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9G9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081000"/>
    <dbReference type="HOGENOM" id="CLU_2037528_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="121" mass="13109" checksum="DA29808757B90DE0" modified="2008-04-08" version="1">MQQLRQRNPARHSQPPVSPSFKNPSAGDVAHNRYREEMSRANWMVGPVLCFNRIQTFGFGLDSGTSLMPYPVTGRGDLDSHGSRGRLSLVSLVDAVCESPCPPSFLGHPPSDTNASLVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9J5</accession>
    <name>B0Y9J5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidyl-arginine deiminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_081260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9J5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081260"/>
    <dbReference type="HOGENOM" id="CLU_037682_2_0_1"/>
    <dbReference type="OrthoDB" id="544103at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377:SF0">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="378" mass="42315" checksum="7A6EE62ABB2BE0B8" modified="2008-04-08" version="1">MLPPLETGRFFFPPEWHPHIATILGFPSQAATCGELYLQNCREIVDLAAAIAEFEPVRLYARPEDVPGVQQLVHRTVDDPSRVTVIPTSINHCWVRDTGPVYVHDASGELDPKQRLAISFEFNEWGNKNGWEGIDGDYRYANPSMSPEALQENTDFARNVIESDTAPSPVQVVKSRIRTEGGGLVVDGEGTLIVAESYMVCDQRNPGMSRDEIEAELRRLLGVEKVIWVPGRKGLDITDCHVDAEVRFIRPGVLVWSRHHPSVPQVWLDMSQEIRNILEDETDAKGRKFELHAIDEPGPEDLGIQEHDEFVSGYANFYFCNGGVIVPGFGVEEYDRKARETLQALMPERKVRQVQLNAIPLSGGVIHCVTQQIPMPAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Q4</accession>
    <name>MYO1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">myoA</name>
        <name type="ORF">AFUB_081890</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
        <text evidence="1">Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation (By similarity).</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylation of the TEDS site (Ser-372) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP48747" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48747.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9Q4"/>
    <dbReference type="SMR" id="B0Y9Q4"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9Q4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000254">
        <property type="entry name" value="Myosin I MyoA/Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054489">
        <property type="entry name" value="Myo1_CA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22773">
        <property type="entry name" value="Myo1_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0505">Motor protein</keyword>
    <keyword id="KW-0518">Myosin</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0728">SH3 domain</keyword>
    <feature type="chain" id="PRO_0000338538" description="Myosin-1">
        <location>
            <begin position="1"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="4">
        <location>
            <begin position="51"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="IQ 1">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="IQ 2">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="5">
        <location>
            <begin position="788"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1076"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="1">
        <location>
            <begin position="419"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="962"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1126"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1139"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1151"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="1249" mass="137289" checksum="DF7F820A1423C050" modified="2008-06-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9V9</accession>
    <name>B0Y9V9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_082440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9V9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082440"/>
    <dbReference type="HOGENOM" id="CLU_011914_2_1_1"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9V9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="3">
        <location>
            <begin position="365"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="648" mass="72688" checksum="A3CD17E3E77741DC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Y3</accession>
    <name>B0Y9Y3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease P complex subunit Pop2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_082690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9Y3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082690"/>
    <dbReference type="HOGENOM" id="CLU_048451_1_0_1"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9Y3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000053">
        <property type="entry name" value="Ribonuclease P complex subunit Pop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="318" mass="34170" checksum="7CB0716E663B024B" modified="2008-04-08" version="1">MFYDLNVPYSSDDPEISDTLSFLAELGYTTVALSQTISGKLPSNLAPPPAPTNAPKNLKLLSRVNLMLSDPAQNQRLASLAQVYDLVALRPTNEKALLNACTNLECDLISLDLSVRLPFYFKFKMLSAAIERGVRLEICYGPGVTGSGLEARRNLIGNAMSLIRATRGRGIVVSSEAKRALGVRAPWDVINLTCVWGLSQELGKEAISEEARKVTALAKLKRTSWRGVIDIVDGGQMSKSQVMESGMGQKGMSKKNFSQAQVTGDNLKRKASLGSEAAVEIEKPLSKREMKRRAKKARLEAGECGGNAAGPGATVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Z1</accession>
    <name>B0Y9Z1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_082770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082770"/>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9Z1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="542"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="765"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1393"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP48834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2209" mass="249854" checksum="AA2271E305FFC7A1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA42</accession>
    <name>B0YA42_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_083340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA42"/>
    <dbReference type="HOGENOM" id="CLU_006586_10_7_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B0YA42"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000316">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122564" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="31"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="523" mass="57285" checksum="5E5F61444AD7BE1A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAJ5</accession>
    <name>B0YAJ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antigenic thaumatin domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_084880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084880"/>
    <dbReference type="HOGENOM" id="CLU_083650_2_1_1"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="PhylomeDB" id="B0YAJ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF6">
        <property type="entry name" value="SECRETED THAUMATIN-LIKE PROTEIN CALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760555" evidence="1">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="167" mass="17347" checksum="3D2A4C239463F6E6" modified="2008-04-08" version="1">MSFSKFFSLAAAFALTASALPLAPRAPSGGVQIVNNMGENVYLWSVSDTSSDMQTVQPGSSYVETWRINPNGGGVSIKISTAADLASVLQFEYTEAGETLFWDLSSINLSPDSPLIAAGFGVSIDDASCPTASCAPGDVNCAESYQFPDDHNTRACGTGAAFTLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAL8</accession>
    <name>B0YAL8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pfs domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_085110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085110"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="PhylomeDB" id="B0YAL8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="381" mass="41593" checksum="356EDB5A4CEA1702" modified="2008-04-08" version="1">MFKHLNMVTSENDLISAVLSIAFQIYLTCSLITWFSLRDVTTSECPGSTNNFNVAIISASQQELTAVKALFDEDYGIVGDISGVHPLDTNAYVAGRIGNHKVILTQISKYGKVFAAKTSFWLSISFPQIRICLVVSTGAGVPCTKDGQEIRLGDVLVSEGIIEYDLGKLLPGGVFLRKTGPLYDFPPPTGHIARLLNSVRRRQARDMLKERMSQHLNYLQATISDLKATNYPSGEGNKLLPQLSLPCFPGSNSCVFNLEARNKNALFVAKCASLDSEPRVGAWAWLDIPAIEYFRPNIHLGWLASGDRIMRSAESRDQIATQEGVIGFEWAGVGAWRQLPTVVITGVGNYGDGYGTDPWPAYASASAASCAKAMLEVYNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAM9</accession>
    <name>B0YAM9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_085220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085220"/>
    <dbReference type="HOGENOM" id="CLU_010399_2_0_1"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="PhylomeDB" id="B0YAM9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="283"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="687" mass="78202" checksum="7AE4DA17967E7BFD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAN1</accession>
    <name>B0YAN1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CmcJ-like methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_085240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085240"/>
    <dbReference type="HOGENOM" id="CLU_042688_0_1_1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="PhylomeDB" id="B0YAN1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="237" mass="27701" checksum="8541061C89F4B4CC" modified="2008-04-08" version="1">MDDPGSTVQASMFFLTPDELHKQQRPYTFKFPPYNGCPQSNMTHEKINGITVENMRGREDQFQLERNGFTILKVNTGLEYDDFFKQKGVTQYLRLMEGVLKARLGANGTVYEYDQPTTVAHVDEIRRQYGKEADGLLKKRFQWINFWKPLRGPVNDWPLVLCDSSLIDVRKDLAVADLLYPDLATENQVMYYRDGLKWYYLSDHEPSEIIVFKQMDSLNSACPGRWMSHKIKCLYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAS8</accession>
    <name>B0YAS8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_085700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EDP49121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2084347_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="117" mass="12702" checksum="DED9BBC22B6CD229" modified="2008-04-08" version="1">MICPFGALQVSRSSPDSRIPGFLTDWPIVTSCGMSYSACPAIWAPSPDFRWNLAWRCRCQGRTGVVYNVLVHSTDVTSTASPGLRTLTSGTMYRISNIYVLAAFGTIGGALFGFDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAT4</accession>
    <name>B0YAT4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_085760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085760"/>
    <dbReference type="HOGENOM" id="CLU_2978718_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="58" mass="6317" checksum="9089547B2FA2D159" modified="2008-04-08" version="1">MHAEWQTGEGYLSSLDDNQHASTVRPKGLSQAKPFSHFIGRHGIGLYCGGGVCERESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB02</accession>
    <name>B0YB02_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FluG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080010"/>
    <dbReference type="HOGENOM" id="CLU_019568_0_0_1"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="PhylomeDB" id="B0YB02"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="87014" checksum="B3435419F32EF755" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBD2</accession>
    <name>B0YBD2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-amino acid oxidase LaoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_092390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092390"/>
    <dbReference type="HOGENOM" id="CLU_004498_8_2_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="PhylomeDB" id="B0YBD2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.240:FF:000001">
        <property type="entry name" value="L-amino acid oxidase LaoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760827" evidence="1">
        <location>
            <begin position="22"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="697" mass="78613" checksum="8CA8F714C26705CB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBF3</accession>
    <name>B0YBF3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_092610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092610"/>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="PhylomeDB" id="B0YBF3"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000022">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP48543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="448" mass="49689" checksum="0166F9835489BC86" modified="2008-04-08" version="1">MKRTYEVYLSIERKARPTSRPTSLTTPVSAVQDTTTVNGNSLKGLPSLVGMKEWLQSLGHSDNAVNGLNVIHVSGTKGKGSTCAFTRSFLRAHSVRTGLPKKIGLYTGPHLQCVRERIQIDDHPVAEELFTRYFFEVWDRIMPADIELDAGVAKQPRYLQFLALLAFHTFIKEEVDAAIFEVHHGGEYDATNVIRNPVVTGITSLGMDHVAQLGPTIETIAWHKAGIFKPGAPAFSVTQDPGPAEVMQKRALDKGTTLTFVSANECLPTDGRVLSVPVQRLNCSLALELTKAFLRTKTPGHTLSDADIYHGVQSFRLTGRFEIIDEGKLQWFVDGAHNVLSLEQTAEWFARNVNNEQKCRALVFSHLSEERDGVALVRSLAHTLFKNKVKPGHVIFTTYQEKDGDPIGNKACKGNRGSRRWNASPCYGELIHGWWNTQPSEGIIVAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBT6</accession>
    <name>B0YBT6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_087770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087770"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B0YBT6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000699">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="517" mass="57747" checksum="B535F0C8C26918E4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC94</accession>
    <name>B0YC94_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB11a, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_089390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089390"/>
    <dbReference type="HOGENOM" id="CLU_1209561_0_0_1"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="PhylomeDB" id="B0YC94"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="163"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="229" mass="25643" checksum="F3AFDEB6A2603142" modified="2008-04-08" version="1">MLPNEMAYARWIHATGGSPAQVLTHVPFPHLSILYKVSECWVSRLTLCLFYSFESFVLSPGEEKVEVETDTRKFFNQTSRCKSTTTDLMHLGIPSSSIFTFNKEDHTLGNLLRSRLLQNSHVIFAGYKVCPPMEAVFSSILFEVLGAFLESFGMHGSDELSQVPHPLVPKFELRVQTDGEITPKDALLAACHDLVKDLGILSREFTKEYELRKMVGATQQQQNGTAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC96</accession>
    <name>B0YC96_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/calcium exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_089410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089410"/>
    <dbReference type="HOGENOM" id="CLU_004979_2_0_1"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="PhylomeDB" id="B0YC96"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="884"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="932"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="966"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="120"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="825"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="988" mass="107829" checksum="29CDF35CE08A5F84" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCN2</accession>
    <name>B0YCN2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">CTP synthase</fullName>
            <ecNumber evidence="3 12">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_090790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 12"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090790"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_1"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="PhylomeDB" id="B0YCN2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="13">
        <location>
            <begin position="315"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="581" mass="64869" checksum="7D0E33A588B98DCD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCX2</accession>
    <name>B0YCX2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_093500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCX2"/>
    <dbReference type="MEROPS" id="T01.976"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093500"/>
    <dbReference type="HOGENOM" id="CLU_035750_8_0_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="PhylomeDB" id="B0YCX2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="262" mass="28755" checksum="12A1CB6ADB3F42E4" modified="2008-04-08" version="1">MFRNNYDNDAVTFSPQGRIFQVEYAQEAVKQGSVVVGLVNKTHAVLVGLKRNAEELSSYQKKIIEVDSHMGIAIAGLASDARVLSNYMKQQCLSSRMTYGRPLPVDRIVTQIGDRAQTNTQQYGKRPYGVGLLVAGVDEAGPHLFEFQPSGMTQEMLACAIGARSQMARTYLERNLDKFADCSREELISHGLRALKETLSHDKELTVDNTSVGVVGLAGEGAQGKIETFKLYDGQSISPLLEALEQTDSGETKEEESMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD28</accession>
    <name>B0YD28_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_094060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094060"/>
    <dbReference type="HOGENOM" id="CLU_074922_0_0_1"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="PhylomeDB" id="B0YD28"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP47562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="234" mass="26090" checksum="909B984B3FF20BC7" modified="2008-04-08" version="1">MEDTPLASLSLTHVHYNPEDPLSLLSAWLALVPQALCVAYVTLIWASREMEVILMFSGQMGCEAFNFVLKRIIKEERPKQMLGKGYGMPSSHAQFVTYFAVYLTLFLLVRHIPTVPKPDTTSYFLMRMALAAGVCLGAGAVATSRIYLNYHTPKQVLAGCAAGVLCAVSWFVATSFLRTEGYVDWVLDLGISQFLRLRDLVVSQDLAEAGWLQWVRQRKLKGRGHSDQPSTKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDE3</accession>
    <name>B0YDE3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_095260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095260"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B0YDE3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="168"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="608" mass="67471" checksum="028A49F888BFBE38" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDK5</accession>
    <name>B0YDK5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_095910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
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        </location>
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        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="307" mass="33081" checksum="2ACE92FCC4237581" modified="2008-04-08" version="1">MTGDSVKKVSSMDRKSWQTQSSSAGSGGKTRSIRSASVTATGTDLGEGDAATRLEGGLKKLTISEGLKREGKPAAISTAQPKVIKCLRSPGDYVFIDIETPGEKSNANSNSSPGISPKAKSAEVGSGEDESGEHEAWTLLTIQAEAANDQDPRSIVEKRLTQRQLEVIRHIVKNIFQGQSDEDTKTGKALQNAKKWDTKNTKCIKCFGDCPVCSKACCIFDVARRTAAQADSTPEHAEAANQILKLIQRLGNSVLEATTYSLCTTPGGCGRYVCSDCWGICPVELCHDVQCKDCKEDPWAACDWHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDL6</accession>
    <name>B0YDL6_ASPFC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">AFUB_096020</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096020"/>
    <dbReference type="HOGENOM" id="CLU_1916592_0_0_1"/>
    <dbReference type="OrthoDB" id="4483219at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="132" mass="14829" checksum="3493EB7BB780F1A4" modified="2008-04-08" version="1">MERSQRLCKSTAPASFNAARPHSTKVVADAPPNKDMSLLDCWILGPEKHRMDNIIRSWECFTIRPLARTTIGCGKQGFPSAQPYLSHTPAVMPFCCLVFLSQPEHSGDEDPVNIFSHDSSWPTPWSPLQIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDM4</accession>
    <name>B0YDM4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS toxin efflux pump, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_096100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096100"/>
    <dbReference type="HOGENOM" id="CLU_029039_0_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B0YDM4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
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    </feature>
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        <location>
            <begin position="91"/>
            <end position="636"/>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP47758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="636" mass="70454" checksum="5AD6BE2DF6AEB0BD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDN6</accession>
    <name>B0YDN6_ASPFC</name>
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        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 31 protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096220</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2024" name="PNAS Nexus" volume="3" first="pgae482" last="pgae482">
            <title>Substrate binding and catalytic mechanism of UDP-alpha-D-galactofuranose: beta-galactofuranoside beta-(15)-galactofuranosyltransferase GfsA.</title>
            <authorList>
                <person name="Oka T."/>
                <person name="Okuno A."/>
                <person name="Hira D."/>
                <person name="Teramoto T."/>
                <person name="Chihara Y."/>
                <person name="Hirata R."/>
                <person name="Kadooka C."/>
                <person name="Kakuta Y."/>
            </authorList>
            <dbReference type="PubMed" id="39507050"/>
            <dbReference type="DOI" id="10.1093/pnasnexus/pgae482"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 43-537 IN COMPLEX WITH MN(2+) AND UDP</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="8YRL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.37 A"/>
        <property type="chains" value="A/B=43-537"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDN6"/>
    <dbReference type="SMR" id="B0YDN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096220"/>
    <dbReference type="HOGENOM" id="CLU_024640_1_0_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="PhylomeDB" id="B0YDN6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000029">
        <property type="entry name" value="Glycosyltransferase family 31 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="77"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="8YRL"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="61285" checksum="99330245E1B7C4FD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDS1</accession>
    <name>B0YDS1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096580"/>
    <dbReference type="HOGENOM" id="CLU_785509_0_0_1"/>
    <dbReference type="OrthoDB" id="4506575at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="43918" checksum="4F65D0B874907E4D" modified="2008-04-08" version="1">MNRQISYNGPLATSSFPVRKSQFGTVPFPCTFPPSNFPSSLPSGPLNHPLPPKPPTSKYFFHAYTPLRLRTPSESTTSPRINHGGCVPVTGEPKSPSLDHQMRVLGGTKAENIISLPSEDTIQGLESDCEVTSSFSFDDADPPRPETFLRAQNHDPFGRKSSFSPRCADDGLCHADAIPVSEVPETPPSTIKSSGGASVSDKDDDGLLSRCMLYEGEEGLLDVPRSKVQTSSGQVAETSPPQLSRKVIQHATSSSLYIKVERSKQASARSKPIRRKRPAGAALETDEKASGPQTRARARAEASEASEASSPLPIARSARPYSAAEDDILEILVARGLAWEEIEKEFGLRFAKRTMRCLQMRWSRKLKRTAPSTRCSKRKRSSASLEFSDAKAPLHKPSYKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE43</accession>
    <name>B0YE43_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_097780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE43"/>
    <dbReference type="HOGENOM" id="CLU_986863_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0YE43"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="282" mass="32001" checksum="1AF6AFA4BF201046" modified="2008-04-08" version="1">MRLYVAPEMDSDFQGQMTSNSSFKSAVRTCEKDIRAHFIPARQWLQSVLELSRAQVAVLKGENSLARHFHVPFASDSIAQRVENLFGELRVLKDENGELDDDIRWIDVLLAPTYEPTPQEDGSLYLRLDGRKGLIKMSTSDHDLIQTGIPQKLLNPRTYESDVLAEREIMKLVEQELANLNNVASQSQYPSSYGIQDFVSRLIRFLRSETQSLTQTMMDCQGWEKGLRLSSNLRMSQVTLKELNQPTRSGRTHKPSHSAKLPPAPLSGQHKKVKADDVDLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEE2</accession>
    <name>B0YEE2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Di-, tri-valent inorganic cation transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_098870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098870"/>
    <dbReference type="HOGENOM" id="CLU_013430_4_0_1"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="PhylomeDB" id="B0YEE2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="333" mass="36044" checksum="FA056EA61A5D6413" modified="2008-04-08" version="1">MVIGISSCFFLTEISFGLYTHSLALVADAFHYLTDLIGLVVALLALKLSEIDDPPKILAFGWQRAPVLGAFFNGALLFALGISILLQAVERFISLHNSCSLLDALAWVLISSALLFFMAGLSFWMCSPVANVKALEKSSHTHRHALDTSTDSSIGAHDEGSIRLPPERTGSSCRDVGMLGVLLHVIGDAVNNLGVMIAALVIWFTEYEGRYYADPGASLWIGVIIILSSLPLLRKAGSILLGCTPSGIDLNDLRSDLEKIQGVLSIHEINVWHISQHKSLAVIGVLLTDQQVPGSTKVISMVNECCQKYGIQSVALRQKLHSQELSLAALDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEF5</accession>
    <name>B0YEF5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_099000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEF5"/>
    <dbReference type="SMR" id="B0YEF5"/>
    <dbReference type="ESTHER" id="aspfu-q4w9r3">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099000"/>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B0YEF5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000430">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122559" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="111"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP47299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="600" mass="66321" checksum="D625F56897F96531" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEF7</accession>
    <name>B0YEF7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane-spanning ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_099020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099020"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_14_1"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="PhylomeDB" id="B0YEF7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="145"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="419" mass="46381" checksum="805DEDDF43D330D8" modified="2008-04-08" version="1">MASARGPRWQQFLQELVMVAGTSASAYFLIRYLLSRLDFDPESQKKEEQRRKSAAILRKLDGGEESDGDSPRRGAKKARRQRRGDLVLNQYEQAIAMDVVAPDDIHVSFEDIGGLDDIIEELKESVIYPLTMPHLYSSTSSLLNAPSGVLLYGPPGCGKTMLAKALAHESGACFINLHISTLTEKWYGDSNKLVNAVFSLARKLQPSIVFIDEIDAVLGTRRSGEHEASGMVKAEFMTHWDGLTSANSLGEPQRVVVLGATNRIQDIDEAILRRMPKKFPVTLPPAAQRLRILSLILKDTKVDRENFDVHYLVKAMAGMSGSDIKEACRDAAMVPVRELIRQKKAEGLQMTSVNPTEVRGLRTEDFFSRAGGVRVISQPSQHQTRPTSKASSEKEWSTAESDAASEVESRPAEMTEPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEI0</accession>
    <name>B0YEI0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Guanine deaminase</fullName>
            <shortName evidence="12">Guanase</shortName>
            <ecNumber evidence="4 12">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_099250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4 12"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEI0"/>
    <dbReference type="HOGENOM" id="CLU_012358_0_0_1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="PhylomeDB" id="B0YEI0"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000021">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="13">
        <location>
            <begin position="94"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP47324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="543" mass="58819" checksum="114445B2E114034B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM13</accession>
    <name>B0XM13_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_001610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001610"/>
    <dbReference type="HOGENOM" id="CLU_030037_0_0_1"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="PhylomeDB" id="B0XM13"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="85965" checksum="B25F835EDC7CFFFC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMF3</accession>
    <name>B0XMF3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTM1-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_000050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000050"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
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    <dbReference type="PhylomeDB" id="B0XMF3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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    </feature>
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    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="286" mass="32231" checksum="3E7927778EA6EA54" modified="2008-04-08" version="1">MATETSSFKLYRYDPSIFAAVVFVLLFLVGSCIHTYQVARTRTWFFVPFVFGGYFEWIGYIGRAISGTQSPNWTVQPYIQQTLLLLIAPTLFAASIYMELGRIVLLTNGDIHCWVRRQWLTKIFLLGDIISFIMQGAGGGIMASGSASALSTGEHIIIGGLVVQLIFFSLFLVTTVKFHIGIQNSPPRKVLHSQTPWERHIYAMYGGSLLIFIRSLFRLIEYAQGNDGYLVTHEAYMYIFDGVLMLLTMGVFAWVHPSEINALLKPGNKAIRRVYFLYSVGNRIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN69</accession>
    <name>B0XN69_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_014780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_007604_0_0_1"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="PhylomeDB" id="B0XN69"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fungal_trans"/>
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            <end position="440"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="785" mass="87611" checksum="6130E748DCB6C284" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN99</accession>
    <name>B0XN99_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_004210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004210"/>
    <dbReference type="HOGENOM" id="CLU_004083_7_3_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="PhylomeDB" id="B0XN99"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="821" mass="91707" checksum="1912571F9A4F0162" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNL9</accession>
    <name>B0XNL9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_004750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNL9"/>
    <dbReference type="HOGENOM" id="CLU_019422_1_1_1"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="PhylomeDB" id="B0XNL9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="244"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="519" mass="58562" checksum="516E7F75CC5D0129" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNS5</accession>
    <name>B0XNS5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="11">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_005340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Membrane</location>
            <topology evidence="2 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005340"/>
    <dbReference type="HOGENOM" id="CLU_009031_2_2_1"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="PhylomeDB" id="B0XNS5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990748">
        <property type="term" value="P:cellular detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006642">
        <property type="term" value="P:triglyceride mobilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8 10 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="13">
        <location>
            <begin position="275"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="628"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="10">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP55835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="712" mass="81948" checksum="02D627455EB89EBB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP14</accession>
    <name>B0XP14_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_005570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005570"/>
    <dbReference type="HOGENOM" id="CLU_163540_1_1_1"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="PhylomeDB" id="B0XP14"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="90" mass="10310" checksum="D5F56F68EB266A41" modified="2008-04-08" version="1">MPAYELRSGGDVRNKKQSVADLKYRRLTELNARLKEDLDRPRVKVSEAAMSLINYCNNTRDFMVPSVWGQVDKREDPYAPQQQGGCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP66</accession>
    <name>B0XP66_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vacuolar sorting receptor (Mrl1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_006100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP66"/>
    <dbReference type="HOGENOM" id="CLU_064145_0_0_1"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="PhylomeDB" id="B0XP66"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000024">
        <property type="entry name" value="Putative vacuolar sorting receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760025" evidence="11">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP55909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="351" mass="38091" checksum="6D6BB83AC6862257" modified="2008-04-08" version="1">MKSLAGSFVGLLFLLSAPVTSVYAASEPTGKKDGLSPCVVRSPATGLYYDLNAISVPRPDPSDGKKSNKNAPRESWHAKGHDYHANFTLNICAPVVEDIKDVVGVERDRWKNVSAYYEKEGKIYSIGEQAAQPLFRGRKLVLNYTNGSPCPGEQIGHSSRNKSTIMSFLCDRDALSHQAVASFVGTMDQCTYFFEVRSAAACGSIGHAHGDGLGPGGVFGVIALIAVAAYLVGGCAYQRTVMHQRGWRQCPNYSLWAGIFDFVKVSALALIPFRMCLGFCLNPIDMFIIVFSSLGRLFRVRRSSNLGHGRADGSSGGFIGAIGGRRGRDNYASDVDAENRLIDQLDETWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPP2</accession>
    <name>B0XPP2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">AFUB_007080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007080"/>
    <dbReference type="HOGENOM" id="CLU_035060_0_2_1"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="PhylomeDB" id="B0XPP2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="374" mass="41914" checksum="A8162A1D81B5028D" modified="2008-04-08" version="1">MVRHKKDNFSRGGKKFSSNPRPRPRPVPRDDDDGSATNRPAFKAACWDLGHCDPKRCSGKRLMHFGLMRELAIGQKFAGVVISPNAKKILSPADRELLEQFGAAVVECSWVRVKEVPWSRIGGRCERLLPYLIAANTVNYGRPWRLNCVEALAACFCICGHEDWAREVLKHFNYGEAFLEINSALLKRYAACATEEDIKKAEEEWLAKIEREYEENRAEGGADDMWTVGNTNRRAASAESDAEDEEKDEQSEGEGEDKEEAEEERDPYAISDDSEDEAQMAEIRAKILNSKSFQNPSVPDKPQPEKIARPDPTPLEDSDAESGSAVSDDEEFDKIINATPVTDRTGIIAASQRKGKETFSASFSRTVINAPQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPQ7</accession>
    <name>B0XPQ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nulp1-pending protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_007230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007230"/>
    <dbReference type="HOGENOM" id="CLU_008321_1_1_1"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="PhylomeDB" id="B0XPQ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="728" mass="82721" checksum="4489CA8F548A96EC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ23</accession>
    <name>B0XQ23_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_008430</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008430"/>
    <dbReference type="HOGENOM" id="CLU_009710_3_2_1"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ23"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="432"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="586"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP56137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="651" mass="72911" checksum="BC8DFAA4C25F125C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ45</accession>
    <name>B0XQ45_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1000 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_008650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008650"/>
    <dbReference type="HOGENOM" id="CLU_072377_2_0_1"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ45"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000003">
        <property type="entry name" value="DUF1000 domain protein (AFU_orthologue AFUA_1G09230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="181" mass="19827" checksum="45EB6710960CF014" modified="2008-04-08" version="1">MQSAEATPKSGTAIVQKTWADRLNDEPELESDADEQLLMYIPFTGQVKLHSLLIYTAPTLSAPKRLKLFKNRNDLDFATASDLTPTQTIEIPQPVPGSDVFELPLSRAHWNATTSITLFFEDNWSSGEEDVTKVGYIGFKGQFMALNREPVSFLYEAAANPSDHVAIPGVSGVGGRVMPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQC7</accession>
    <name>B0XQC7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_009490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009490"/>
    <dbReference type="HOGENOM" id="CLU_035240_1_0_1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001704">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002658">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002265">
        <property type="entry name" value="Specific RNA polymerase II transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="521"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="570" mass="62606" checksum="8C3C334EE80C6EE6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQG6</accession>
    <name>B0XQG6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_009880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009880"/>
    <dbReference type="HOGENOM" id="CLU_1199553_0_0_1"/>
    <dbReference type="OrthoDB" id="4226308at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="231" mass="26035" checksum="72F84FBEE339E0C9" modified="2008-04-08" version="1">MDLDPTLMKSTNSTTGLRSFSVNTNAMNPATTRLSRRLLIFQEARNPSNMSEIVYLPVNKLGLPICGSGPELPSILELPLRILRAFTEIFNQPKYKGCYPALQMEYLLLIFRKWPETETYWLINRPGLPVSRHSPLVYNIPSDPILIPELLASLTETLTSDLAVYMGYQFVDTWPATTTTTTSNDSNSTDYFVLLERHTSTNEPQSQTQTQDREANADHAPSTGYQETCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQL9</accession>
    <name>B0XQL9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_010420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010420"/>
    <dbReference type="HOGENOM" id="CLU_008599_2_3_1"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="PhylomeDB" id="B0XQL9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000025">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="795" mass="88263" checksum="A7B8AC76F9F1A361" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQM6</accession>
    <name>B0XQM6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_010500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQM6"/>
    <dbReference type="HOGENOM" id="CLU_008613_3_0_1"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="PhylomeDB" id="B0XQM6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035960">
        <property type="entry name" value="Secretoglobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48201">
        <property type="entry name" value="Uteroglobin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="693" mass="75678" checksum="537F7FA7A6CEDAD7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQZ6</accession>
    <name>B0XQZ6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS peptide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_011710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011710"/>
    <dbReference type="HOGENOM" id="CLU_004790_4_1_1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="B0XQZ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="603" mass="67312" checksum="809219ADFB562E15" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRF2</accession>
    <name>B0XRF2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_002260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002260"/>
    <dbReference type="HOGENOM" id="CLU_068297_0_1_1"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="PhylomeDB" id="B0XRF2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP55531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="247" mass="27663" checksum="A35FB5EAEC93D1E5" modified="2008-04-08" version="1">MHLTLMNGTLRTAALSGRFALASPSPLPTATPLFQCCQKMSLRTQARPVSTSTTRILLKPSPRPQTSSMCLSPIFRKTAFRLNSTAANASRAEVPKLDWNSFFKLRASRRRYTLASSIIASMASTIIGVQILSEQDLESLGAQVMGLDPFVVLGLATATCGAVGWLAGPFLGNAIWRLVYRKYKPAFLMREKEFYDRIKRFRVDPSSNSIANPVPDYYGEKIGSVQGYRQWLKDQRAYNRKRRSFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRK1</accession>
    <name>B0XRK1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_012960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012960"/>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="PhylomeDB" id="B0XRK1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="280" mass="30994" checksum="FA7B8C535A0953CE" modified="2008-04-08" version="1">MAANGLYNIYRLAIPVATGAMIFNASIYDVRGGTRAVIFDRLSGVQEKVVNEGTHFLIPWLQKAIIYDVRTKPRNISTTTGSKDLQMVSLTLRVLHRPDVPKLPVIYQTYGTDYDERVLPSIGNEVLKAIVAQFDAAELITQREAVSNRIRTDLLKRAAQFNIALEDVSITHMTFGKEFTRAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESAEIISKAVAKAGSGLIEIRRIDATKEIAQTLANNPNVTYLPGNEGKDGGKSTSLLLGLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRL7</accession>
    <name>B0XRL7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_013120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013120"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="PhylomeDB" id="B0XRL7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05198">
        <property type="entry name" value="formate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="184"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="322" mass="35030" checksum="ED4028EF3D70AEE3" modified="2008-04-08" version="1">MSANLSPKHHHIVFLQADYCPIPNFRFPPGHTFTTAVYQQTSLSELHSRIHDASIVVFSYIPFDAHTLSPEVTPHLKLIAVAAVGTDCIDLEACRKRGIIVSRSVGANVDSVSEHAIGLYFASRRRILDMHMLTRAGEWAHKKGTIMYQLLDKHGQPPLSCQDEVVGIIGYGVVDPATSSSLSTVDNIERAPFDAVIRQSTVIFVAVPLSPSTRNLISNPELKNMSPHTVIVNVSRGGIVDEDALLEALKKGTIAGAATDVFRQEPAGLDNSPLLSDEAKNLNLIVTPHLAWLSKKTLANYSQMVQQAIEGWSAGQPCNVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS14</accession>
    <name>B0XS14_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_025570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025570"/>
    <dbReference type="HOGENOM" id="CLU_507238_0_0_1"/>
    <dbReference type="OrthoDB" id="4185962at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="643" mass="69412" checksum="660A127F3E54E865" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS93</accession>
    <name>B0XS93_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 299 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_026380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026380"/>
    <dbReference type="HOGENOM" id="CLU_084284_0_0_1"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="PhylomeDB" id="B0XS93"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="242" mass="27542" checksum="14EE460EBB493E68" modified="2008-04-08" version="1">MRSTFRLLANVKSARYLEPFAPTGLTGLVTHPSPRPTLIHLYRTTLENLKRFPESSVYRQSTEALTRHRLQIVESVKPPGYDAWLERVKKAVSAEPERFASLRLADGTYAGFMRNDGTDNPRGEEWDGEALEPTTEGPARTAEEEARWHKAIEEATATTQAKDSDFATEQMKWENEPALEAEQIAEIEKQIGAGLIEEVIQVAENELKLVDEMYKSKVWEELEEKPRPGQWVYFDRVPPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSF5</accession>
    <name>B0XSF5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldo-keto reductase ausK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_027010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027010"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B0XSF5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19147">
        <property type="entry name" value="AKR_AKR9A3_9B1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000024">
        <property type="entry name" value="Aryl-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="384" mass="42762" checksum="541686D6265B4A05" modified="2008-04-08" version="1">MSEFFRPAPEPRTELGRYRILSSTAGIRVSPLQLGAMSIGDAWSDFMGSMDKESSFKLLDAFVEAGGNFIDTANNYQDEQSETWIGEWMAARQNRDQLVLATKFTIDYKAHALGKGNAVNHSGNHRRSLHMSVRDSLKKLQTDWIDILYLHWWDHTTSIEEIMDSLHILVEQGKVLYLGISDTPAWVVSAANTYARAHGKTPFSVYQGRWNVMLRDFEREIIPMTRHFGMALAPWDVLGSGKFQTKKALEERKKKGEGLRSMFGPGEQTEDEVKMSEALAKVAAEHGIESVTAIALAYVRAKAPNVFPIVGGRKVEHLHDNIQALSIKLTPEQIEYLESVKPMDLGFPSNLIGSDPKVTGKPTLLLAATAPFVFETGSKPIGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSI5</accession>
    <name>B0XSI5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AFUB_027310</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027310"/>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_1"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="PhylomeDB" id="B0XSI5"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="20">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="21">
        <location>
            <begin position="215"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP54671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="385" mass="43766" checksum="0A371B231F4869B8" modified="2008-04-08" version="1">MVESVLDDISHRRFNPLRGSYVLVSPHRTKRPWQGQQESPSKTTLPAYDPACYLCPGNKRAQGDTNPKYEKTFVFVNDYSAVKEEQAPYSPESGDSVESFFLKAEPVTGKCYVLTFSAAHNLTLADLSPAEIIPVIDAWTEIYSAHLSPKSPLAAVAPATTLPPNSPIANMAKPKEQYRYMQIFENKGAAMGCSNPHPHGQVWTTSSLPEEPAMELEQMKKYRREHQNKHLLEDYAALESRKQERVVFENQAFLVVCPWWATWPFETMIVSKKHKRALVDLNENEKAQLAEAIAEITRRYDNLFETHFPYSMGIHQAPLEGTDEEIEASYLHLHFYPPLLRSATVRKFLVGYEMMAEPQRDITPEQAAARLRACGGELYRKKMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSQ4</accession>
    <name>B0XSQ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_017220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017220"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B0XSQ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF13">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="347"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="456"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="671" mass="74376" checksum="4880B6D38713F3CB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSX0</accession>
    <name>B0XSX0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_028080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSX0"/>
    <dbReference type="HOGENOM" id="CLU_076635_2_1_1"/>
    <dbReference type="OrthoDB" id="5408734at2759"/>
    <dbReference type="PhylomeDB" id="B0XSX0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="131" mass="15058" checksum="122BB1D575E1EC5E" modified="2008-04-08" version="1">MSDMEQEWKPKGRPQSTMAQAFSSTLDSVFALDSEVDHLSQTIDQNWVDQWSWHLRRFQMIIQTRELEELQAKIRETERRLKARQSLIMDGNGSGNSAGASKVENEYRTADSAGQYSSSDEQREQDRNGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSZ0</accession>
    <name>B0XSZ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allergen Asp F13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_028280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSZ0"/>
    <dbReference type="SMR" id="B0XSZ0"/>
    <dbReference type="Allergome" id="67">
        <property type="allergen name" value="Asp f 15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028280"/>
    <dbReference type="HOGENOM" id="CLU_111635_0_0_1"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="PhylomeDB" id="B0XSZ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760447" evidence="4">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="152" mass="15944" checksum="5516BEBA23653CB5" modified="2008-04-08" version="1">MKFTTPISLISLFVSSALAAPTPENEARDAIPVSVSYDPRYDNAGTSMNDVSCSNGVNGLVTKWPTFGSVPGFARIGGAPTIPGWNSPNCGKCYKLQYEQNTIYVTAIDAAPGGFNIATSAMDQLTNGMAVELGRVQATYEEADPSHCASGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU23</accession>
    <name>B0XU23_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_030060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030060"/>
    <dbReference type="HOGENOM" id="CLU_022195_7_0_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="PhylomeDB" id="B0XU23"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="375" mass="42999" checksum="033CCE4425F4A8D4" modified="2008-04-08" version="1">MFGFEWHNQRGVEGTGFVRALRSRLTAHLPILMPELQRIVETAIADELVAPGSDGKWGSPQLCLIPSDCSRLRALQTVPYDQANGHQGQLLRLLRGGTWYDYPWHVRHRQAHCVAAQNPEFTAAALEFPQRVILAAEILRITPSFLRRTLFRYLKPIVEKRLAARANSPRSLQEDAPMDCMQWLIDTSPRKIPWTPTRMVGEIVAVWFGSVHQLAMVRSYSARRNLTVRRKALTPFMFSDGLEVAEGDWVCIPQRAMMRDRIRYQNPQAFDGFRFARANKQLRAGDVSLDVPENSPLTMTDVSVDWPIWGLGKTACPGRFYAATILKLIMVCILEKWECRLENPKSQRWRTWRSSVVPREGTVVMFRRKEEALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUE6</accession>
    <name>B0XUE6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_020460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUE6"/>
    <dbReference type="SMR" id="B0XUE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020460"/>
    <dbReference type="HOGENOM" id="CLU_007727_0_3_1"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="PhylomeDB" id="B0XUE6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="37"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="688" mass="76044" checksum="B90AEB3101DCDDAD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUL6</accession>
    <name>B0XUL6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_031320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031320"/>
    <dbReference type="HOGENOM" id="CLU_038290_1_0_1"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="289" mass="31674" checksum="890DF9E32C29E607" modified="2008-04-08" version="1">MMVEDEFYAMAQTFTKHLHYAEYVKRKKEAKLQNAAAIKDLARPTDGVTPRSEETKRKEAAATLSARQRAGLEKMGGTRPQLDSDKEEDDTDEDDGLAGTSLGYLMTSPRKARSLVGMQGVKSSTRAAAGFAQASGSKRRKTNPDAHTHSSLKAEIEADDHVADATATEDDDLDVQVTKTSTRPTEKKHSIGSDANSPALRTSSSTPQYTANNDKGKRPVRVIHRTPPLGRSRRKVFVDDFDELPEPSNPNPSAHGRLISHTTNNTNDPNESGVNSKKSRLNEVPTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUN1</accession>
    <name>B0XUN1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_020660</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020660"/>
    <dbReference type="HOGENOM" id="CLU_025086_2_0_1"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="PhylomeDB" id="B0XUN1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="19">
        <location>
            <begin position="223"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP54016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="58518" checksum="E776C1818F112995" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUN3</accession>
    <name>B0XUN3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NUDIX family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_020680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUN3"/>
    <dbReference type="HOGENOM" id="CLU_018689_0_0_1"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="PhylomeDB" id="B0XUN3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="344" mass="38267" checksum="539E0FEDC20FAEF7" modified="2008-04-08" version="1">MAAKKGATGDTQAELKLTCNSVILISPKNEVLLLHRVKTSTSFASAHVFPGGNLSAEDGECPAAEDPKRHEDAQWYRTAAVRELFEESGILLARDKNTGVMLAVSEAEREKGRRAIHQHEVTFVDWLKKQNAAAVPDIADGATEPLIPFTRWITPTNVPKRYSTQMYLYFLPLPAESDQSVLNEIPAEGEREEIQVPTSDGGVEITEAMFLPAAEWLRKAQSGEIIMFPPQFLLLHLVSQFLDKEPRATASPEELRNRRAELVEFVHSGTPPWTEKCISPKMLKMSSDGRTVLALDHPGPELDGTNRAGEPDRVVYVQFKQGAARKLDVRWKKDVFAEQAKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUP1</accession>
    <name>B0XUP1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_020760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUP1"/>
    <dbReference type="HOGENOM" id="CLU_019095_0_1_1"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="PhylomeDB" id="B0XUP1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7492" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="307" mass="33864" checksum="DDE6B1A40DF10284" modified="2008-04-08" version="1">MTNLIPPDGRANLSQILPSDRLCKDTQQKQFQTDGSPRLQANPGAAIALRFQENGHVTLPQNQAGKPRNRGTVYVYGTTEPKDDERLLDIHNVWNKEGTGGDGRGVLLSTQNFDDGRCYQINSGQISKHRQAMYPHEANQLMGADLWCQQDIALPSEAPTGKPYTLYWVWDWPTAPGVDPSLPNGKQEIYTTCIDVDVIDSPPTHERVPANYVEDQSLNNAAIPSQFAEIFGMKLPSFSAPVSSTSRLIPTPTAVPKQPTPATVTSFITLTKTVQPDAWQTSLGSSIPSYSTPSFSSPAWNWFRRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUR9</accession>
    <name>B0XUR9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF52 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_021040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021040"/>
    <dbReference type="HOGENOM" id="CLU_038085_0_0_1"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="PhylomeDB" id="B0XUR9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="402" mass="44073" checksum="DEE467DFE886F0A3" modified="2008-04-08" version="1">MDDASPTCSTITEDVSTTASKIYAKIVNIKKGKADIMQSREPSHAGSWYSDNRSTLTRQLDQWLAHVPNEIEGIGSLPVPGSRVIIAPHAGYAYSGPCAAYAYRALDLSKAKRIFILGPSHHHYLSTLALPQLTSYYTPLSDEPLPLDTELIAKLLSAKAVKPNGSTVSFTTMTRSVDEDEHSIELHLPYIHRLLQLQHPTKRTSQYPPLVPILVGSTSASTEQAFGALLASYLEDPSNVFVISSDFCHWGLRFSYTYYVPQAPKPGPKLPLSADALPQPSNDLDEFEERIELVSAGHSLQRRDRINSREPAIHESISAFDIATMAAIATGETENFLDVIQRTGNTVCGRHPIGVIMAAIEATRTQEDGKKGAFHFIRYERSSDAVNVTDSSVSYVSAFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUT9</accession>
    <name>B0XUT9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_031400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUT9"/>
    <dbReference type="HOGENOM" id="CLU_005595_0_0_1"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="PhylomeDB" id="B0XUT9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="347"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="826" mass="91612" checksum="A052FBEA27343C04" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV65</accession>
    <name>B0XV65_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_021830</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP54131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002210_0_0_1"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="PhylomeDB" id="B0XV65"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
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            <end position="1418"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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    </feature>
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    </feature>
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        <location>
            <begin position="336"/>
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        </location>
    </feature>
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        <location>
            <begin position="700"/>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1263"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1429" mass="157023" checksum="B07A8020274267EA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVD0</accession>
    <name>B0XVD0_ASPFC</name>
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        <submittedName>
            <fullName evidence="4">PT repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_032690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
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    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1009"/>
            <end position="1024"/>
        </location>
    </feature>
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        <location>
            <begin position="1067"/>
            <end position="1096"/>
        </location>
    </feature>
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        <location>
            <begin position="1100"/>
            <end position="1118"/>
        </location>
    </feature>
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            <begin position="1119"/>
            <end position="1238"/>
        </location>
    </feature>
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        <location>
            <begin position="1249"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1331"/>
            <end position="1458"/>
        </location>
    </feature>
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        <location>
            <begin position="1469"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1531"/>
            <end position="1586"/>
        </location>
    </feature>
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        <location>
            <begin position="1597"/>
            <end position="1666"/>
        </location>
    </feature>
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        <location>
            <begin position="1667"/>
            <end position="1691"/>
        </location>
    </feature>
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        <location>
            <begin position="1718"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1772"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1809"/>
            <end position="1838"/>
        </location>
    </feature>
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        <location>
            <begin position="1872"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1885"/>
            <end position="1900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2016" mass="209318" checksum="2AF6504D0D8A6B91" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVX1</accession>
    <name>B0XVX1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial respiratory complex I chaperone (Cia84), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_023100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
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        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
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        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="821" mass="93545" checksum="D1BE72F5D55307A5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVZ0</accession>
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        <recommendedName>
            <fullName evidence="2">DUF4246 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">AFUB_033490</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
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                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
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    </dbReference>
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        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="117" mass="13387" checksum="5D57E64166D5D95A" modified="2008-04-08" version="1">MMTSSARNTGEWQRSQPINRPEPGEFDPHPFYNQINLCKEYGERGLQVIVKLANIELTPEKPEYAGGSWHIEGQLSTLTFHQRAISSKIENISYEQSRHELLQQVFGSRPEVDGSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVZ5</accession>
    <name>B0XVZ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_033540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_393266_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="644" mass="72150" checksum="ECF385C1FB3B94B2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWB0</accession>
    <name>B0XWB0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flotillin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_024180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024180"/>
    <dbReference type="HOGENOM" id="CLU_030844_1_1_1"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="PhylomeDB" id="B0XWB0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF31">
        <property type="entry name" value="FLOTILLIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="90"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="516" mass="57782" checksum="7DD1F1E532B1205E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXI3</accession>
    <name>B0XXI3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_048430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048430"/>
    <dbReference type="HOGENOM" id="CLU_114624_0_0_1"/>
    <dbReference type="OrthoDB" id="4358740at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="170" mass="19093" checksum="4BCC0E89CD94398F" modified="2008-04-08" version="1">MVEQKPLRVLVIISDTNAYWEKSWSASEDLLPVAFEILQENCLVENTYNHWPKMRLLAKEKWATRVFLVFDISNTSYDPEVGHLPQQNNLPVAIVRLGATVQAYTAAIPVQNKINKDVARAHNNSGIKSLPPFVVDYTSGPPTYLNPRDPSLLRQTTGSTNFASFCYVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXT0</accession>
    <name>B0XXT0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_038450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038450"/>
    <dbReference type="HOGENOM" id="CLU_046586_0_0_1"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="PhylomeDB" id="B0XXT0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="115"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="357" mass="39587" checksum="C735BEAA7D48D692" modified="2008-04-08" version="1">MSLRHIIRRAARSQPSFTVTRSYANQTPGNPVIDVFNRKVKHIQRDRAARNVEESRKTDYLKDEVATRLCERLLASSSALDIKRNFPHVLDLGANSCNIARALTTPNPDPSTETSPPLANKISKLTCIDTSHALLYRDADEPFNKSIDLERQVVPDLETLPFEPNTFDAVLSSLSIHWINDLPSLLAQVNSILKPDCPFIAAMFGGDTLFELRTSLQLADLERRGGVSPHVSPLADVRDVGGLLNKAGFKMLTVDVEDIVVEFPDTFALMQDLQAMGENNAILHRELGPISRDVLLANEAIYRELHKEEGSRGIPATFRLIYMIGWKEGEGQAQPLQRGSGQVNLKDILGGGSFDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY71</accession>
    <name>B0XY71_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_039860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039860"/>
    <dbReference type="HOGENOM" id="CLU_138038_0_0_1"/>
    <dbReference type="OrthoDB" id="4509983at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="163" mass="18168" checksum="56051A90C8F7D3D1" modified="2008-04-08" version="1">MLALIGNRRWRISQFPDPVRAKRYMEDVDRLFFPLVQEDVRLTSARDNRAPVLSNILQARQSTSSSDNCNCPNSISGGGIAGIVIGSIVGTLLLIWLFRVCSLPGAWGGGEPDHGYSGGGGTEVRSTHRRSRSSPSYVDYVDKPSRSRRYREDIRRPAKVYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYF5</accession>
    <name>B0XYF5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_040730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040730"/>
    <dbReference type="HOGENOM" id="CLU_2849264_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="65" mass="7562" checksum="C5118A0FA5BF0169" modified="2008-04-08" version="1">MVALKYRNQFQRPESYVCSRCKHFVASGTDDAVDCGHEADWTTRESTFPKRSSEEPQLWVVMVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYI7</accession>
    <name>B0XYI7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor (OTam), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_041060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041060"/>
    <dbReference type="HOGENOM" id="CLU_006632_1_2_1"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="PhylomeDB" id="B0XYI7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="684"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="726" mass="80115" checksum="A6598582272D4CEF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYK6</accession>
    <name>B0XYK6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular serine-rich protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_041240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYK6"/>
    <dbReference type="HOGENOM" id="CLU_010712_0_0_1"/>
    <dbReference type="OrthoDB" id="2113314at2759"/>
    <dbReference type="PhylomeDB" id="B0XYK6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agd3 CBM87" evidence="2">
        <location>
            <begin position="120"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="1">
        <location>
            <begin position="347"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="3">
        <location>
            <begin position="713"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="781" mass="83764" checksum="1618D39262744293" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYR4</accession>
    <name>B0XYR4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_041810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041810"/>
    <dbReference type="HOGENOM" id="CLU_012494_3_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B0XYR4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF242">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="62"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="32152" checksum="E66F08395819789A" modified="2008-04-08" version="1">MSLLIYIYRKVLAVLIRAVVTRGKRISANPDDVLQITSRDAGRHLRAHLYRPATSLSPSPVLINFHGSGFLLPLHGSDDEFCRRVSRETEYTVLDVQYRLAPEYPFPAALNDVEDAVKWVLQQPDKFDLTRVAISGFSAGGNLAIVAASVLYPRETFRSVLAFYPPLDLYTDPGAKRPPDPAGNPIPAPLCRLFDKSYVPSAYDARDPRISPCYAQPERFPDRVLVVTAAGDSLAGEAEALAAKIAKLPGRQVVCQRMQGCNHAWDKSARPGTIQGDAKEKAYAMAVAMLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZJ2</accession>
    <name>B0XZJ2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MobA-like NTP transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_034060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034060"/>
    <dbReference type="HOGENOM" id="CLU_055597_3_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobA-like NTP transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="162" mass="17822" checksum="B9F85C04D6DA6A06" modified="2008-04-08" version="1">MSTLKPLLLAGGHSSRMGTRKELLRVAGDVPLFVHLLIILHEACPESEVVFLSLRDHNSLKAIENDRHITAVPDNRLILTNGTTTFPVHVVYDGPGVPSEHDSAGIGPGAGLLAAHHQDQSAHWLVVACDYPFISTAALSQLRREWTAPVTCFENRDCFLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZM5</accession>
    <name>B0XZM5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_044560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044560"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="B0XZM5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="426" mass="48577" checksum="6B30D51BEE17A151" modified="2008-04-08" version="1">MPFSRPPLPPGILVDEEISPLYDSKYFYPAKPGEVLADHYQTLVKVGWGVSSTVWLARDLQRIVALKIVNNNASSAGHEREVEEHISTADPSHRGRSVIRTLLDSFEVKGPEGSYLCLVYPPMRESLLMYQHRFDDRKIPLPLIKTYIRALLTGLDYLHKVCRIVHTAILTPSGCLDLKLENIMVSFEDPTVLADFTDSQLAIPTPFKIDSAGRPVYQSHNDFGPLKSLRSIPQLVDFGLATRLEEDDDWGVWPIQSDHYRAPEVILGNGWQMPADIWNLGVLLWDMIDGKELFRHIHDKEGRYDARLHIAETIALLGPPPPEVIQRYQYMREYSWPKPVKREDGRVCETAEEYFCGPFFDEKGCFLYENLIPNRKLSDTASFLGGEEKETFLDLAKRMLVWHPDARETAGELAGHPFLQPKHTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0B3</accession>
    <name>B0Y0B3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cation transporting ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_035400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0Y0B3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035400"/>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0B3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1122"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1201"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1241"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="258"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1277"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP52377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1303" mass="145555" checksum="6B8B5E48DFDE9268" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0P7</accession>
    <name>UBA4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="3">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="3">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Sulfurtransferase uba4</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">uba4</name>
        <name evidence="3" type="synonym">cnxF</name>
        <name type="ORF">AFUB_058070</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="3"/>
    <dbReference type="EC" id="2.8.1.11" evidence="3"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0P7"/>
    <dbReference type="SMR" id="B0Y0P7"/>
    <dbReference type="EnsemblFungi" id="EDP51788">
        <property type="protein sequence ID" value="EDP51788"/>
        <property type="gene ID" value="AFUB_058070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058070"/>
    <dbReference type="HOGENOM" id="CLU_013325_1_2_1"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0P7"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000096">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000369218" description="Adenylyltransferase and sulfurtransferase uba4">
        <location>
            <begin position="1"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="376"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="3">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P38820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <sequence length="493" mass="53385" checksum="99E0E0C659EA575E" modified="2008-04-08" version="1">MENLEQTCASLRAQIAATEAQLAGLKRELEIAEQAAEVKAQSTTRTITAEDGKTNETREWPLLSEEYKRYGRQMIVPQLGLQGQLKLRAARVLIVGAGGLGCPAALYLAGAGVGTLGLVDGDTVENSNLHRQVLHSSKNVGTFKVDSAIEYLRELNPHPTYVPYRAHLTPQEAPGIFKDYDIVLDCTDNPATRYLISDTAVLLGKPLVSASALRTEGQLMVLNYPPRPVGDKSGGPCYRCVFPKPPPANSVVSCADGGILGPVVGTMGVLQALEAIKVITSPAVNPSASPPSLLIFSAYSTPLFRTIRLRARRANCAVCSADASVTLETLKNGSTDYVFFCGVAGLEATLSPEERISPLEFKKRHPKEVPQDGGRINKEPTIIDVREKVQFDICSLENSINIPISTILSSASSPTNVDANAQPSLPFWLPRELASADSTDPIYVVCRHGNDSQIAVRRLKELGLDRGGQRYVGDIQGGLRAWREQIDPDWPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y103</accession>
    <name>B0Y103_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparaginase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_059140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y103"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059140"/>
    <dbReference type="HOGENOM" id="CLU_021603_5_2_1"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="PhylomeDB" id="B0Y103"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="318"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="442" mass="46512" checksum="569B40F515CF3BDA" modified="2008-04-08" version="1">MSQPQRGGGISAIFVHVGAGYHGHGNERAHLQVCENACKAAMGILKSGGSALDAVEMAIIVMEDDEITNAGYGSNLTIEGAVECDATIVDHHGRSGAAGAVSPRMLLETSAKPLTCHRVPPSFLVGEGATDFAYEQGLVILPPDGLISRFSKERWHRWLQDLEAAELVERKRDPSRFRMEEDRASFLRRPMLNRNPARLIDNTRLRPHLPSSPFTGVDLLNPLPRLQALGSRQTIAPAPPAMPSNQGHGMGPAIGQPMAVAGGQSMASAPEQGMAASANTHADGATFRACPTKAPCAPDTSTTAHPGAADEDEDMISDTVGAIAVDCYGNIAAGSSSGGIGAKHRGRIGPAALVGIGTYVIPVDPSDPEQVSVASVTSGTGEHIATTMAAQTSAARLYYCQKKCKDGTFESVSEDEAMNAIIATEFMGELLYSIFLTTIDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y111</accession>
    <name>B0Y111_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA wybutosine-synthesizing protein 2</fullName>
            <shortName evidence="2">tRNA-yW-synthesizing protein 2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_059220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y111"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059220"/>
    <dbReference type="HOGENOM" id="CLU_023588_0_0_1"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="PhylomeDB" id="B0Y111"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026274">
        <property type="entry name" value="tRNA_wybutosine_synth_prot_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038972">
        <property type="entry name" value="Trm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="4">
        <location>
            <begin position="107"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="448" mass="49902" checksum="8D05D591129FD5AD" modified="2008-04-08" version="1">MHSDDPTGDHTPDERVKKPTTHKREPKSRNKCSNPLRKGIQNFVTRHIPSDDLAKHGMSLESLESALPKRFTVYEQLLLLPVNALSDPPAWGSLYASLDSQKRRLLFESIATAFGRMGVTRIAMNAPIAPMNTQGGENRMRSPTGLIPLYGDFGLVPFWDGENAQPTQEDFQRAFWVQTMQNQGIVQIWAPLYTMFSRGNITEKARILGQGSVFEGLDEGTLGEKIDSISVVDLYAGIGYFVFSYLKRGVKRVWGWEINGWSVEGLRRGCTENGWGCKVVGIGNDGTLSESVPDLVDSLQDSDRVVLFHGDNKFAARVMGEIKGHMERRDAWNRIRHVNLGLLPSSRGAWSDACAMIDLQLGGWMHVHENVDVQHIDAKKQEIITEIGRLRAIAFPSAVQQPIECRHIENVKTYAPGVMHCVFDIKLPPSGETPTGLELSRASKQSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y178</accession>
    <name>B0Y178_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS alpha-glucoside transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_048970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y178"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048970"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B0Y178"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001649">
        <property type="entry name" value="MFS alpha-glucoside transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF15">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="531" mass="58455" checksum="88D1CA20E6B4B725" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y182</accession>
    <name>B0Y182_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FacC-like extracellular signaling protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_049010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y182"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049010"/>
    <dbReference type="HOGENOM" id="CLU_052172_0_0_1"/>
    <dbReference type="OrthoDB" id="4180726at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048799">
        <property type="entry name" value="P68_RBP_TagC-like_beta-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21311">
        <property type="entry name" value="Phage_RBD_prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758529" evidence="1">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="P68 RBP/TagC-like beta-propeller" evidence="2">
        <location>
            <begin position="45"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="310" mass="33940" checksum="CDB49587C65DCA09" modified="2008-04-08" version="1">MRVSLFAIITALTCVIAKIPDSPRFDLTKPSYDLWRNKKTAAKTVQQSFTFDNVNRRLFIVNRRDGSALDSGDLTISQLDFSGKVLGSMHLLGCGHGVNIAAEPIGSDTYIWSETDAAASGYGTALWKFKFQNGKTLNSATDKRKRIVPLPEFDRGTATIDPVYKRLIVRYQTGTVQNIAAFDLAEASAGNFSNPLAKWEIPHLVKELGAKVNVFQGYTAYGRYVYFLTGESYDASGGKLNSEVMALDLNTGKLVQGPVTTKAGSTLKFREPEGMAIYKTASGEVRLFLGFASGVAGDRRSNLFYKNALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1F4</accession>
    <name>B0Y1F4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, 2OG-Fe(II) oxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_060140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060140"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1F4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="196"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="354" mass="39300" checksum="6E33AFCAF8FA9766" modified="2008-04-08" version="1">MDNLAHHACHPITTAIEKDNLVIPVIDFGPFLKGTPSDKHAVAVSITNAFKTSGFLYLKNHGIPFSTVSQVFETSARFFARPQDQKDSLCWTSPQSNRGYVKTGREKLSLPEDNVDKDAARLATPDLKETMEIGRDDVEGHPNRWPDHIDDEGKEFKKVIQLFFGMCKSLHTEVMRAIALGLNLPEHYFDEFVDAGDNNLRLLHYPSVPKDVFKKNSGQVRAAEHSDYGSITLLFQDRRGGLQVRSPKGTFVDATPIADTVVVNAGDLLARWSNDIIKSTRHRVVEPPSIAGVDGDDSSDTYPARYSIAYFCNPNMNKFIDALPGTFGEGTSQKKKYPGITAGDYLVQRLTATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1I3</accession>
    <name>B0Y1I3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_049400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1I3"/>
    <dbReference type="ESTHER" id="aspfu-q4wdx0">
        <property type="family name" value="Tannase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049400"/>
    <dbReference type="HOGENOM" id="CLU_014819_3_2_1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1I3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF13">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="505" mass="54802" checksum="FD12924B1BD1C251" modified="2008-04-08" version="1">MSHIGPAIECSPSAIPTPAVFGAEILSLEASWVRNFTLDVPGNFNYNHGAQSVQNVDFCNVTVTYSHPGYDDRITVETWLPRHWNQRLQATGGGGWRAGRFVLSQFFMGGAIGEGYATTTTDAGLGDTMPDAWALKSTGNVNLEYLHNLGYRSLNDEAIIAKDLVRSFYGIPPAYSYWSGCSQGGRQGLMLAQRYPHAYDGIVASAPAQSWPEFVTAVYYPLLAPLWAGEPSPLSCELEFLTAEAVKHCDSQDGIVDGIISDPNNCDFDPFSAVNKTFSCTATGKPMRLTRAAAITAKAAWTGPRTVAGDFLWYGVNPGSDITGLGVAPGQNLTTSPDEWLSLFLVKNQSFDATQLSHEEYGTLFHFSVKEYTDVMAANDPDLTAFKKAGGKLLTYHGMADESIPTKGTEHYYRAVSQLIPDVQDFYRYFESPGLAHCAGGRGGQPTTAFDALRKWVENGTAPEFLPVRVNGTDGEHNRILCPYPAKPIQQGGNASGVGSFRCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1N4</accession>
    <name>B0Y1N4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_049920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1N4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049920"/>
    <dbReference type="HOGENOM" id="CLU_894239_0_0_1"/>
    <dbReference type="OrthoDB" id="4993731at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="323" mass="37146" checksum="465BE9FB38652884" modified="2008-04-08" version="1">MPVTRSVTRASELNAEKSTIKSTSKQQNVLHGINNTSMKINAKDPSAAETPPQSCRLIEWISLKDPPNGVVPNSDELFATLQEIHKLKECIIIARGRPRELSEIEWLIIEWRSKKGREEFLTSELSLKLNEALAHRSWSQELAWPIHNTGMIIRANPLFPPQRIYEVLIIYFPANLDTEAIYSIETFRGLPCWHIDGEDPAEYPSAALKSQIPAWIEGTCEYQRQTARRLAYFIEFANEEGERIYKEKVRYNPRGRPPWDVMVNFFDELKDLGMIGYESLHVEFVEVVHYVPENYIPEPPRPISPEAKKRANSLPAYDSDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y251</accession>
    <name>B0Y251_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_061270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y251"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061270"/>
    <dbReference type="HOGENOM" id="CLU_029790_3_0_1"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="PhylomeDB" id="B0Y251"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF16">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="32509" checksum="74FD7DCC17778230" modified="2008-04-08" version="1">MLVFRNQTSYNRFWDGRNGMNTIVTCVRNLVRTIITNSYSERGPPTAAEQQDVERTIRVLMAIPYAVKNHLRDEWGAAWALGSDVNENGTAVYDADYASLLPVGLEGHEHDGLGLPFQLTFFVDGFIKRGVERGWFNAPGASQMQAQLNTLTDAYGRMETIKLTPIPVAHLIHQKQVLALFGCVLPFAMVDDMRWWAVPIVSLVIFTLYGIEGIGSQLEDPFGYDRNDIKMDAIVGDAKIEIGAVLSEWRNLMASVQANHPPVVGNGVTEERKASFAPPDMFLRAAPRVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y282</accession>
    <name>B0Y282_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">mRNA export factor Mlo3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_061610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y282"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061610"/>
    <dbReference type="HOGENOM" id="CLU_158071_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="85" mass="8887" checksum="9B24B50C0EDB325B" modified="2008-04-08" version="1">MSTKLDKSLDEILVNRRQNARRRTRRPAASKPGSAAVPVGGVKKNAKAAKPVAKGAQGGHPVATESKIMVSGLPSDVNEANIKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2C2</accession>
    <name>B0Y2C2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase fal1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_050940</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2C2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050940"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2C2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="65"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="246"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP51092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="429" mass="48899" checksum="B06E3F10A467AABD" modified="2008-04-08" version="1">MADGIDRRTDEIWANGANSDRLEFSTSKEVTVAPTFEDMHLKESLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISILQVIDTVVRETQALVLSPTRELATQIQSVIMALGDYMNVQCHACIGGTNIGEDIRKLDYGQHVVSGTPGRVADMIRRRHLRTRHIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRVLVKRDELTLEGIKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGEMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPTNRENYIHRIGRSGRFGRKGVAINFVTSDDVRILRDIELYYSTQIDEMPMNGKSSDFTRFPLMAQRYTYSCLVADLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2G5</accession>
    <name>B0Y2G5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_051370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2G5"/>
    <dbReference type="HOGENOM" id="CLU_030671_1_1_1"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2G5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF8">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38999" checksum="051A46CC88C70A05" modified="2008-04-08" version="1">MGSQSPWDTPFDELPNPKQVWVGKPGSHEEGLGKLAILTPEVVAKAAAAEIKTGRRVTMNWDMTKLDYPNLNRQPCNHQIIPLLGGVAFDDIYTMNPRRSLPGVDLNLKLTVTTLEQSSQWDGLRHFSQTVPGQKERVFYGGTTVEEINDRRNDRIGLQHWAKEGIAGKLQPARRGVLIDYATWAEKKGIKYTTFSTHQVRLSDMLEIAKECNITFQKGDILLVRVGVTKEWDTIMTDAQKQQYSDNPSPEHAGVEATTDVLRWLWDTGFAAIASDAISWEVYPPQNPDLFLHEYVLAGWGMPIGELFDLEALASTCQELQRWTFFVASVPLNMPGGVSSPPNMMAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y399</accession>
    <name>B0Y399_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_053440</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y399"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053440"/>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="PhylomeDB" id="B0Y399"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000535">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011026">
        <property type="entry name" value="WAS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47912">
        <property type="entry name" value="Wiscott-Aldrich syndrome protein, WASP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="77"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="545"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="261"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP51340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="835" mass="92330" checksum="6ECEC4ECB3F1CEE1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3C1</accession>
    <name>B0Y3C1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA damage and replication checkpoint protein Rfx1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_053680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3C1"/>
    <dbReference type="HOGENOM" id="CLU_011526_0_1_1"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3C1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="855" mass="94704" checksum="17B7969A62D4F867" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3P6</accession>
    <name>B0Y3P6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_054950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3P6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054950"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3P6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="480"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="581" mass="63039" checksum="E4CC618A2C3444D7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y409</accession>
    <name>B0Y409_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_056110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y409"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056110"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PhylomeDB" id="B0Y409"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000822">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="76"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="338"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="396" mass="45193" checksum="2A2B48645C4CF72A" modified="2008-04-08" version="1">MATGKAEPSTHSEIPSSSPPSRGVDTPLEDVQKREKQMVASFRPPHQRSVNPFVIKDRLEERQLGISTRTLCVNDFTLIKTLGTGTFARVWLAKFKDETIRRDNVYALKVLRKADVIKLKQVEHVRNERKALAAVAGHPFITTLIASFSDEQSLYMLLDYCPGGEIFSYLRRARRFNETTSRFYAAEITLTIEYLHDVEGIVYRDLKPENILLDADGHIKLVDFGFAKQINDRETYTLCGTPEYLAPEVIHNSGHGLAVDWWALGILIYEFLVGQPPFWDQNPMRIYEQIVEGRLRFPPNMSPAAQNIISCLCKTNPSERLGHISGGSARVKAHPFFEDINWDDLFHRRMKGPIIPRVDHPADTGNFEDYPDVDVKGQAIYTDDMKKKYEALFSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y450</accession>
    <name>B0Y450_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 9.5 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_056520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y450"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056520"/>
    <dbReference type="HOGENOM" id="CLU_166990_0_1_1"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="PhylomeDB" id="B0Y450"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="76" mass="8670" checksum="D24E0C26DD739F76" modified="2008-04-08" version="1">MTTPQFWSTPLRYLRWASHEKPAIFYSLVVGATGPLMLVTLPPIRRFFGDVDPEPIPLTYPLPQGPRNIPQGYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y476</accession>
    <name>B0Y476_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_056780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="10">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y476"/>
    <dbReference type="HOGENOM" id="CLU_056632_4_1_1"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="PhylomeDB" id="B0Y476"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902693">
        <property type="term" value="C:superoxide dismutase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016670">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901856">
        <property type="term" value="P:negative regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9 10" id="KW-0186">Copper</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="11">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP51667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="158" mass="16361" checksum="D64BF7B45B097AAE" modified="2008-04-08" version="1">MQGVTPPVIAVLRGDSKITGTVTFEQADENSPTTVSWNIKGNDPNAKRGFHVHQFGDNTNGCTSAGPHFNPYGKTHGAPEDSERHVGDLGNFETDAEGNAVGSKQDKLIKLIGAESVLGRTLVVHAGTDDLGRGGNEESKKTGNAGARPACGVIGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4D8</accession>
    <name>B0Y4D8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_057430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4D8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057430"/>
    <dbReference type="HOGENOM" id="CLU_1454061_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="186" mass="21134" checksum="98EB5979FA3EF3BA" modified="2008-04-08" version="1">MKANMLPQSPHGNDGYKSIPEDVSQQVIINNGRCFRLEVPKCDDQPRALRQKEQKAIKKKANKVLLSLGRLLRMLLFFRPITSTSVSKRPHPRHKLEVVYYLPSLYRTHRGHHRKGVVVTKLENRVPLVLVVEVLFVFVLLLRMLSTLKGNVTPYMPTHAPIVFGTAKVQNVRSISAPPAMNLSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4J3</accession>
    <name>B0Y4J3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline phytoceramidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_069290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4J3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069290"/>
    <dbReference type="HOGENOM" id="CLU_063293_2_0_1"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4J3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="316" mass="37064" checksum="F8824E1C3F42BB86" modified="2008-04-08" version="1">MPQWSFPTSIPYSPSKDGYWSPVTSTLNWCEEDYYATIYSAEIVNSMTNLLFMWLGFKGIQSCRRYGHDTIFQVAFYGYLVVGAGNPMQLVDELSMIYTTCLMCYASFSYSRPLGFRIVLAVALTSLAVFITLYYHYLQDPVFHQNAYALLTIVVVLRSMYTMEVTLRPSLRHSTEEDRLARQKKDLPVLSKERQHYENVRDVRTLKTMWFMVAYGLAMFLGGFFIWTLDNRFCPTLRRWRRAVGLPWGLFLEGHGWWHVMTGIGAYLYIIWGIWLRHCLNGRQEEYELWWPHFWNFPEIVPVSTDSGSRPAKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4W7</accession>
    <name>B0Y4W7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_070560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070560"/>
    <dbReference type="HOGENOM" id="CLU_2605584_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="79" mass="9135" checksum="24531E8494754CA0" modified="2008-04-08" version="1">MIPDPSPTTAFPRIFSASWTIDSRHGNARKNYVPMLLTIQQLLLKSTRPSKIASSHHAFIFPTLRITIHPPWSRERRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y505</accession>
    <name>B0Y505_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_070950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y505"/>
    <dbReference type="HOGENOM" id="CLU_131040_0_0_1"/>
    <dbReference type="OrthoDB" id="4483229at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053832">
        <property type="entry name" value="DUF6924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21962">
        <property type="entry name" value="DUF6924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6924" evidence="2">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="161" mass="17582" checksum="F758B2294BB8242E" modified="2008-04-08" version="1">MSLIPIICTHEVSPTVITSILSTAYKASTDAAELQEYTDDSVTKLPVESLQYPFLGWDIGKIAQFLQENTSDTIVDYTTFLVADEKTALDEDTLLLVYDVEGLQESIRLSACFANSEAVSVSVATKDVGELWTLADEDGVYRGGPQHPPPKKGGKAPRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5J5</accession>
    <name>B0Y5J5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BZIP transcription factor (MetR), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_063610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5J5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063610"/>
    <dbReference type="HOGENOM" id="CLU_056562_0_0_1"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5J5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="202"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="305" mass="32996" checksum="F06AF91B62D3C6A8" modified="2008-04-08" version="1">MSGYNGRRAPNFSQYLEDLNAIPSPYDQALQQQQRQDTFNLDAELSLFTNTEFFDFDNLGDLNLPSFDAVNEDSAKTTDQQHGGPAAHNPDMEFLDLLGDGFGNMPDFSAANLNSINSQFPAQDTQFSTIPSIPSGLSNAPFNANPTPSQSSSSAASPAGPATSPIAAQAPSATTAAGPKRKNTQKPAPMSVEEAARIAAEEDKRRRNTAASARFRVKKKLREQALEKTVKETTEKNAALEARVTALELENQWLKNLITEKNGKSAEETKKSETDIANMFKKFLSSQKADAERSSSESKIGVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6W5</accession>
    <name>B0Y6W5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_068370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6W5"/>
    <dbReference type="SMR" id="B0Y6W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068370"/>
    <dbReference type="HOGENOM" id="CLU_016207_3_1_1"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6W5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="128"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP50500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="450" mass="49450" checksum="4CAC6FFC43FB85DA" modified="2008-04-08" version="1">MVKQIAGSKVLLLGSGFVTKPTVEVLTKADVHVTVACRTLESAQKLCQGFPNTKAIALDVNDAAALDKALEQADLAISLIPYTFHALVIKSAIRTKKHVVTTSYVSPAMMELDEECKKAGITVMNEIGLDPGIDHLYAVKTISEVHAEGGKITSFLSYCGGLPAPECSDNPLGYKFSWSSRGVLLALRNAAKFYQDGKEFSVAGPDLMATAKPYYIYPGYAFVAYPNRDSCPYRERYQIPEAQTVIRGTLRYQGFPEMIKVLVDIGFLSDEAKDFLNSPIPWKEATQKILGATSSDEKDLEWAIASKTTFTDNDSRNRLISGLRWIGLFSDEQITPRGNPLDTLCATLERKMQYGPGERDMVMLQHKFGIEHKDGSKETRTSTLVEYGDPNGYSAMAKTVGVPCGVAVKLVLDGTISQKGVLAPMTWDICEPLLKTLKEEYGIEMIEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7A9</accession>
    <name>B0Y7A9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_073170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073170"/>
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    <dbReference type="PhylomeDB" id="B0Y7A9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF86">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="678" mass="76756" checksum="D5AAF0B47BEC562D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7Q4</accession>
    <name>B0Y7Q4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_074620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7Q4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074620"/>
    <dbReference type="HOGENOM" id="CLU_007354_0_0_1"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="591"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="850"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1178" mass="125230" checksum="326FAE11F31534E1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7T2</accession>
    <name>B0Y7T2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_074900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074900"/>
    <dbReference type="HOGENOM" id="CLU_2084328_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="117" mass="12850" checksum="80B22AB23E6CF1AE" modified="2008-04-08" version="1">MPSLAAMPCALSYLDIRLHLIFTSDVHLSSLPRRSSPTRFLLCIVVRPSFFRITCSTDIFVRSTYVQGIADFASLFAFLLSLIDFAFGGSGVWIVGRLMCCDLVVGTGIGALRSLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7V6</accession>
    <name>B0Y7V6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G1/S regulator NimO, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_075160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7V6"/>
    <dbReference type="HOGENOM" id="CLU_017715_0_0_1"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7V6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="588"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="650" mass="72713" checksum="491E1E82EB2529B1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8M1</accession>
    <name>B0Y8M1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sodium bile acid symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_077840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8M1"/>
    <dbReference type="HOGENOM" id="CLU_039013_3_0_1"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8M1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000034">
        <property type="entry name" value="Sodium bile acid symporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="418" mass="45617" checksum="AA7DCE2F726F005D" modified="2008-04-08" version="1">MNDKMLNTQSPELSQKNELSDGYSSSRVCASEVDNPSAFPTDHAGVSGLPAPKTPSRSGLMRVLLGIGELAMDQWFLIVMGILIALASQIQVPHAHQELKQTVTNYLAVAVIFFINGCTLPTKVLVENLSRWKMHIFVQMQCYLLTSSTSYGVVSAAATNHQFMDPALLVGIVIMGCLPTAIAFNTIMTRKANGNAALTVAQSTIGNILGPFVTTALIKLYTSTNVWYTDILPKTSSGFGETYRYVFKQLGLSVFVPLAVGQIVVKLFPNQVRKVLLEWKLSKLGSCALLVLIWSTYDGAFASNAFAEIPSNNMVFTVFILVALFCLWITIAFVVSRVWLSREDTIAVSYLVSTKTPAMGVPLTTIMFKGLSAAQQSRTRLPMVIFQAIQIAGSSLLTIPLRKWQAQRKAEETGDGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y990</accession>
    <name>B0Y990_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y990"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080180"/>
    <dbReference type="HOGENOM" id="CLU_002639_2_7_1"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="PhylomeDB" id="B0Y990"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="277"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="747" mass="84814" checksum="DAA5651E4DB0A246" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9A2</accession>
    <name>B0Y9A2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9A2"/>
    <dbReference type="HOGENOM" id="CLU_1532173_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="175" mass="18653" checksum="290CB2BA8E300B38" modified="2008-04-08" version="1">MAYGLIGYGWKPSELLSCQSCVVQKLRQFVNLHELSQHDSQAAEIGKGASSDHATASISEQREGSLKLASVSVEPGQNIDAGCTNHSASCDSSGDARQDNWFERSAAIDNDIVMECDTFPTESHTVDPEPTPSSSFECPRAATSATSEQDCVQQPHSVLPNRVTSVANGNVIVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA49</accession>
    <name>B0YA49_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_083410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083410"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="PhylomeDB" id="B0YA49"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="555" mass="60130" checksum="314FDF8BFD1DE5C9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBB1</accession>
    <name>B0YBB1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isochorismatase family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_092180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092180"/>
    <dbReference type="HOGENOM" id="CLU_068979_5_1_1"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="PhylomeDB" id="B0YBB1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF15">
        <property type="entry name" value="BLR5631 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="4">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="237" mass="25072" checksum="1AD68001E77C1BA6" modified="2008-04-08" version="1">MRKLVLSSSPHSSSSRKPPSSQISLVQCPHYNSQSHNQKMSSVQSFRQLIGVPPSTASAKDSSLIIIDAQNEYATGHLKTANVSQTRKAIAALLEKYRAGGDGKNIVHIVHEVPQGAPVFTPDTDLAKEFDELTPRGGEKVITKHFPSAFAQTDLDEYLTGLGDAGKKVVLVGYMAHVCVSTTARAASERGYDVVIASDAVGDRAIPGASAETLVSVVLSELADAFATVLPSSEITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBF6</accession>
    <name>B0YBF6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_092640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092640"/>
    <dbReference type="HOGENOM" id="CLU_031555_4_1_1"/>
    <dbReference type="PhylomeDB" id="B0YBF6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="158"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="340" mass="38253" checksum="0FC018908D77738A" modified="2008-04-08" version="1">MTEPTHIIDTEGEVIIFLKCPESPFAPWNDDVAEPEPLKSHGDVQKRDNGDNATQEGFNKKVTKKRLKKKNKRGNPMPLQSEMDESADNPAGTPEPADTAMVSADETVDDSVTESANGPTTEPLEEQLQEAQPNASLDGPRENGSEIDCEGALQEPASDVHMRGDCFRIQVSAKHLTLASPIFKETLSGRWKEGLRLLKEGSVEIPIRDWDLEAFLILMDIFHCQAQNLPREICLELLAKIAVLADCYQCQPLVRFFAEIWIGQLRRKIFPTIYSRDSMLWVWVSWNFRQLFEFEKSTSIAISQSNGLITSLDLPIPAKVIRMTQSPPSSHRSRNYGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBX4</accession>
    <name>B0YBX4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_088150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBX4"/>
    <dbReference type="HOGENOM" id="CLU_099558_0_0_1"/>
    <dbReference type="OrthoDB" id="5366688at2759"/>
    <dbReference type="PhylomeDB" id="B0YBX4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20140" checksum="BEB248FF41A3DDF9" modified="2008-04-08" version="1">MARYGALGATFQIARIVQACSLIAIIGLTANFIAEIVSKNATPPSVFIGTITVTCIAVIYCVISFILFLDNILPFLASAIMDALVLVAVIVVAVIIGKPLSYLKCDVIGDLTGDGSSAYAFATSLDNYLDHLGGKVDYKNWIAASRGVCLEAKSIWGLSIALCILFFFSAVCCACLWRQKKATGGEKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC01</accession>
    <name>B0YC01_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_088420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088420"/>
    <dbReference type="HOGENOM" id="CLU_033661_0_2_1"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="PhylomeDB" id="B0YC01"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000431">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="39045" checksum="6A0A191624D60B70" modified="2008-04-08" version="1">MASAGPSGSSINELASKLYDECLKRYDSDHLFYQQDLLGLGVVERNNLPLLLQCTQLLVDQKLFRLLQGKNDRLAWKIISREDAEKLQNLSPDESLVYNVIHSTGRNGIWVRAIQSRTNLHKSILDRCLKSLEGKSYIKSVHNVKFPSRKMYMLAGLAPSEDVTGGAWFTDGVLDANFISTVAGFIEYTVSRKSWYEVPATGNKRLKTADGRASVKQESGEKKYLPYPAGYQGYPTVAMITAAVNESGITPVRLGEESIIQLLEMLCYDKKLVALNNGQFYKSVKNPAAVKMEKNRKPEGDVEDVGDKLVTNGMTEVPCGPCPVFKLCVPGGAVSPETCEYFDPWLQKALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC84</accession>
    <name>B0YC84_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell-cycle checkpoint protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_089280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC84"/>
    <dbReference type="HOGENOM" id="CLU_000288_171_0_1"/>
    <dbReference type="OrthoDB" id="4490803at2759"/>
    <dbReference type="PhylomeDB" id="B0YC84"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001584">
        <property type="entry name" value="Cell-cycle checkpoint protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="409" mass="46731" checksum="24E598C08BFC1E36" modified="2008-04-08" version="1">MAPSYPRTRDTNGFRQQYRVLQQLGKGHFATVYLCVERATGTQYAVKVFERRPGDSQKSQNESLQQEIGLLMGVNHPNLLCLKDTFDEADGVYLVLELAPEGELFNLIVSRQKFSEEETRHIFVQLFEGLKYLHDRGIVHRDIKPENILVADKKLTVKLGDFGLAKIIGEDSFTTTLYVLPLFLQIAFFLLPWLILLFTDVGHQVESRRRRYTKAVDIWSLGVVLYICLCGFPPFSDELYTRENPFTLAQQIKMGRFDYPSPYWDSVGDPALDLIDRMLTVDVEKRITVDECLQHPWLTGKHMSVFDSTEGLTGALGKLDFSKRKVERERTLLSSINDAHFSEHNEGPGAPVKVFHRNNAGKRMHNQPAHTIQQSEAPPDENSAPKDFVNLGERGDPVLFEEDQTSHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCB1</accession>
    <name>B0YCB1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_089560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089560"/>
    <dbReference type="HOGENOM" id="CLU_177181_1_1_1"/>
    <dbReference type="OrthoDB" id="2138648at2759"/>
    <dbReference type="PhylomeDB" id="B0YCB1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="79" mass="8715" checksum="6463A3A0B6367D7F" modified="2008-04-08" version="1">MSAERVKDKKGEIINEGDHVYTRYRGGSHEGDVERIVMDQAEADEENVANPPKVRGRCDFAPTTPNTLSQKVNDANANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCG7</accession>
    <name>B0YCG7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_090130</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090130"/>
    <dbReference type="HOGENOM" id="CLU_001996_0_1_1"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="PhylomeDB" id="B0YCG7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.90:FF:000003">
        <property type="entry name" value="Telomerase reverse transcriptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2630:FF:000003">
        <property type="entry name" value="Telomerase reverse transcriptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="706"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="479"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP48298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1248" mass="142784" checksum="62E1C0DD32C8A5A5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCP5</accession>
    <name>B0YCP5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cellular morphogenesis protein (Rax2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_090920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCP5"/>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="PhylomeDB" id="B0YCP5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000127">
        <property type="entry name" value="Cellular morphogenesis protein (Rax2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760846" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="4">
        <location>
            <begin position="229"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="5">
        <location>
            <begin position="389"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="890"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1203" mass="127883" checksum="93A728B61131696F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCW1</accession>
    <name>B0YCW1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_093390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093390"/>
    <dbReference type="HOGENOM" id="CLU_044499_0_0_1"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="PhylomeDB" id="B0YCW1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="354" mass="38269" checksum="52C3E92C7E26B2C3" modified="2008-04-08" version="1">MTPRLTNCRSLMRGCGKTTPAARFFSSRISRSNIRARLNIQPPFPVAEKCPEPSCSCPATPAMPKGLPIDFDQPLNGTMAAYTQQVVICTGQRDWESRIEDDGKGQSWGELVRGLKKLMGRGGRYADPFNNVLVSNSSFPSSSSTSTASAFLFPRFKYIPSISINVSEEQNAPTNLATFVQAFLLPAQLNPMQDSLPESKRAELTRKSELESSFPGAVDIQYSPVVLICGHGGRDMRCGVMAPVLEKEFSRVLGARGFSPAGADGNPTDSPEHAKIGLISHVGGHKYAGNVIVYIPPGMKAGGSPHPLAGKGIWYGRVEPKHVQGIIDETVMSGRVVLDHFRGGIDRNGDILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD57</accession>
    <name>B0YD57_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="4">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_094360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="4"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094360"/>
    <dbReference type="HOGENOM" id="CLU_026244_0_0_1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="PhylomeDB" id="B0YD57"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF3">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="228"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="360" mass="41221" checksum="1B07480FC9B1C383" modified="2008-04-08" version="1">MQLLFLSAGQTPSYAKRYTHPIGHLPFFCYNGTVSWLQCPEIRRLKRWKKHQMHVLFRLHGIAASRSISSNAGQSSTRFLTIGEKVEYEIAQQSIIAFRSSGDAAFPGPDEIQVVSVRTGRKLRSHVTSTGLVFSTLSDEAPNFEEYFPGLEALLERVDFTKLPYRRSIKYEGHFNWKTMVDGYQECLHCQYTHPSFSVYYPPTFYTVNNHQNFSQHIADPKKPDDGLFLYFFPICTLNVYGGGMSSFRVCPAEDPSQTRMEFDYYHSESGNKFEEYYQFVRQVAMEDYELCEKTQGNLEKGVYTEGILNPEKENGVSFYQDRVFELVCQQHAAESASHDLSAPRLKESEINAEKVGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD80</accession>
    <name>B0YD80_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_094600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD80"/>
    <dbReference type="HOGENOM" id="CLU_018449_2_0_1"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57869" checksum="87CBCBD282AF8D64" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDB5</accession>
    <name>B0YDB5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_094980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094980"/>
    <dbReference type="HOGENOM" id="CLU_051542_0_2_1"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="PhylomeDB" id="B0YDB5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="212" mass="24560" checksum="45B0A2551F0EB6D1" modified="2008-04-08" version="1">MFLLPGIAAFPQFQRVVELARQGGIVLDLGCGLGQNLRLLAACGVPSNQMWALDLSPQLWRLGYELYRDRDRMLATFIPGNFLHEDDCLGLRELYGQVDIMIAGQFLHLFSWEGQKQAGKRIVALSKRGTVLIGYQQSRRRAREYMRPWGMMFYHNRDSFLQMWREISLETSTDWKVEATEVDLAEWGMEAEDTEWMPADRQGLNFVLTRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDC1</accession>
    <name>B0YDC1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic endopeptidase (AP1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_095040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095040"/>
    <dbReference type="HOGENOM" id="CLU_013253_0_2_1"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="PhylomeDB" id="B0YDC1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000092">
        <property type="entry name" value="Aspartic endopeptidase (AP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="118"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="459" mass="50010" checksum="63325ED5D1341B10" modified="2008-04-08" version="1">MSSCRFSNTLKTATASPCKYLHTTTTITMATRIKLLPNPHYRKSGTKSYVHLMRKYRFTPTKGGRYFLSSSLHQTGRQYTHLPVGGRARIQHVLRKRIADTDETSDVGADDVQNDTMYLAPVSIGTPAQTIHLEVDTGSADLWVWSTHLAPATIAQHKTGTVFDPSKSSTFEEQSGSTWKISRDDGSFAFGTVGTDTISLGGLRVEHQAIELADSLSAQYEQGTGDGLLGLAFSHINTVRPQPVRTLVENMVAQEDIPESAKLFTAKLGCWQGANEPDEGEPFFTFGFIDQDIVTASGEEVYYTPIDNSRGFWLFDSASATVNGKTIARSGNKAIADTGTPLALVDDETCQAIYDAIPGAHYDDESQGYIFPSTTTADKLPVVSLAVGDKQFVVQREDLGFAEAKSGYVYGGIQSRGSMAMDILGSTFLKGIYPIFDVGNLRFGAVQRKELHQNLSAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEA0</accession>
    <name>B0YEA0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_098440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098440"/>
    <dbReference type="HOGENOM" id="CLU_038504_1_0_1"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="341" mass="37956" checksum="92926B57381006C9" modified="2008-04-08" version="1">MSRLEKLGDVESQNEDVSTDLTWSTILKWGIITYTSMLIVFISICSCCPSLIETNDTASLEWLASIVQKTSAYSVWTSPADAYGKMNSRTLFVWLDGDVVFLEDHTIPTIVRTMLDNPDSLMVSANVINHAALEALHSHPGVALPYLPELHQASGAAQLPPARVLDWSTSHLPPWAGPEDFRVLKGFAPPGSKHRWLLSDDEHVDRTPISTSMYTTVGPGFSDWTVKAQQHYSFLHHLELGELHRYKFPKWSNPADISPNLLCFWDADANVVQSSILHGSSYVPIRFIEDANKPTKRTVIIDGKGLAAHYSADAGAEDLDSTDILQRYEAYAKEIICPNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0YED0</accession>
    <name>B0YED0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AN1 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_098750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YED0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098750"/>
    <dbReference type="HOGENOM" id="CLU_052358_2_0_1"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="PhylomeDB" id="B0YED0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="312" mass="34636" checksum="818C4F833405D38A" modified="2008-04-08" version="1">MAPITVSKGRTPSPNAQESFTQTADKDLESIGRHCQFEYCHQLDFLPFRCESCRGTFCLEHRTETAHRCPKAGEWARRRNGNQNTSTASLPTQKPTIYNSDQCAHLDCKTLINTLKDPGVRCPDCNRQYCLRHRLREEHECTKIAPLGARAGSQGPSNAETIRSMFARVRTWGKDKGQALAPKPKANSAAARISELNALKKAAKGDAGIPADKRLYLHVVGTADAQAQKAEPPSGDFWFDSRWKVGRVLDDAARRLRIENVNNRAGEEERLRIFHVDSGEFLEFSETIGDGKVKQGHTIVLLRGAGVILGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEK5</accession>
    <name>B0YEK5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_099500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099500"/>
    <dbReference type="HOGENOM" id="CLU_058490_3_2_1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="280" mass="31199" checksum="B160976BE10E1028" modified="2008-04-08" version="1">MVVNADSISRHALGLSPTTSEYPYQGMKHFRDIVYKEAATTRNDYVIFTNIDEHTFLRDFDESLRKSYSDFFPQARILVARMPATEVHEAAHTELHNTLMIMLGAMNVHSQLLSLGVADVVTPTRTKEPDQSYKPMNFPAGYSSHWPSMVIETAFSESQSTPANDARWWLNASGGELKIVITIAVQKKREAITIDKWEATSRPTRGDPGKTVPEVVQKVTITREGGDAPVHVTGAPLIIGFEKLFLRPAEEEKGEGDVLFSHDDLAEIADKVWSVLNTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEY2</accession>
    <name>B0YEY2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_100900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100900"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="PhylomeDB" id="B0YEY2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="80"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="233"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="536" mass="58164" checksum="6672515737DA5C29" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMN5</accession>
    <name>B0XMN5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_003370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMN5"/>
    <dbReference type="HOGENOM" id="CLU_029200_1_0_1"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="586" mass="63052" checksum="55505F1986E861BC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMP7</accession>
    <name>BGALA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-galactosidase A</fullName>
            <ecNumber>3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Lactase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lacA</name>
        <name type="ORF">AFUB_013710</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP56654" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.2.1.23"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56654.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMP7"/>
    <dbReference type="SMR" id="B0XMP7"/>
    <dbReference type="GlyCosmos" id="B0XMP7">
        <property type="glycosylation" value="8 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="B0XMP7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000088">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.390.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395215" description="Probable beta-galactosidase A">
        <location>
            <begin position="19"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="760"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="777"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="914"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="266"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1006" mass="110405" checksum="86CF2FDEF43A85BD" modified="2010-07-13" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN28</accession>
    <name>B0XN28_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_014370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014370"/>
    <dbReference type="HOGENOM" id="CLU_023639_0_0_1"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="PhylomeDB" id="B0XN28"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="243"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="500" mass="52557" checksum="D23C7049DFDC19F7" modified="2008-04-08" version="1">MSSTHDPRLLYSINNILAFHIQNGEETELTPSGPQTLSLLMVPTTASTPQAAGTDGPVEEDFYLHLHLPPELDLALPATTQIYHQPPNSYLIPRWDLGPDAGAFIRIQFPRIGTGPDKVTQEDIDTFETILAQCTAFLERAPPPREHAPYNPASYAPGEGYVSSEQVTSSDAHGKIVLVDEENGSVVGEMEGYQVVEQPGVKPGSKRPVEIQLPAEGEGNKISVSNVSEEYLQMARHPAYKNSTLVQKSAMASRLIVTGSSYIGNVLTSGAESFTKKTKPNPKPMTFSETTHARFRKIGTLSQGAAELSAKTVGQVGKVAQNFGASLTRREGKQKGIDKYGNSSDYKPGILNKSLIAFSTLADGIEQGARNVLTSGSVAASTMIAHRYGAEAGAVASNVTGGIKNVGLVYIDASGVSRKAVLKSVAKGMVVGRMRDGKQVVVGTGDGGEVPPSVGGPSQSLLGGRDPVARRPSPSPTPPPAYGASGTVSLGGTAISGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XND1</accession>
    <name>B0XND1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_004520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XND1"/>
    <dbReference type="HOGENOM" id="CLU_1796010_0_0_1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="144" mass="15647" checksum="D4C46747E7ED9F7B" modified="2008-04-08" version="1">MSTHWDTAKHCHRALSLLAENICHSFTSSQQPRTSPSDPSINPSCEEPAIANPTKRRKLSSCDSLVPLPSASASASAEAMAGQGQAPLNAHESGNGPVELNMTTETTEMEYLNLPDFDMNTVDLLQAANFDYLLDMFGQQYPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNY9</accession>
    <name>B0XNY9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_016150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016150"/>
    <dbReference type="HOGENOM" id="CLU_013985_24_1_1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="PhylomeDB" id="B0XNY9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="205" mass="22932" checksum="C63C93009106B995" modified="2008-04-08" version="1">MEHSFPPTFRTARLRFDALVDADAAGIHAIRRLKEVMKWSLKKVPDADLATTRKWVEEYLRPEPRVPGNVGYVIREIEPVSGSSAAVGGVDGDGKGRIIASIGLRYGFVEALGGKRWELGYIFHPDFWGKGYATEAVRGLMDAWPGIYHRITWGEEQQERSEEVVAITDKGNEPSMRVLRKCGFEAVEEFLDKAGTPCVAFVYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPD5</accession>
    <name>B0XPD5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xenobiotic compound monooxygenase, DszA family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_016960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016960"/>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="PhylomeDB" id="B0XPD5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="41"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="463" mass="51369" checksum="B6C0F0B6B67DEA68" modified="2008-04-08" version="1">MATANASITDSPRKSLILNAFVEMCSGHQSPGLWRHPEDESYRFNDVDHWIELAQLLESAKFHGIFIADVLGGYDVYKGPRNLAPAIVSGAQWPVNEPLAVVSAMAAATKNIGFGVTVTTTYEQPYHLARRLSTVDHLSKGRYHDDRYAIAEEYVRVTYKLWESSWRDDAVVLDRERGIYTDPSRVREINHEGKYFNVPGPHLCQPSPQRTPVILQAGTSKAGKTFAAQHAEAIFVAGHSPVVVAKNIAEIRATAQAQFGRDPKSIKFLALLCPVLGRTEEEAREKFQYYRSLGSIDGALALFGGWTGINLDTYGDDEELRHVESNAIRSAVEGWSKSTPEVAKWTKSTVGQHITVGGLGATPVGTPAQVADEMERWVREADVDGFNLAYAIKPGSFKDIIDLLIPELRRRGLFWEDYAVERGTYRENLYGKPGQTGPPADHPASRYRWHAGVDAADHKIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPI0</accession>
    <name>B0XPI0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_006550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006550"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_1"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="PhylomeDB" id="B0XPI0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="243"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP55953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="464" mass="51703" checksum="DA42E2C5D5849407" modified="2008-04-08" version="1">MSTLEDLEDLEREERDKKKDQGDGDGQQPGGDGDAEMKDADAKKKDEEDDLLDEEILNSSTADIVKRRRMLENELRIMKSEYQRLTHEQNTMREKVRDNQEKIENNRQLPYLVGNVVELLDLDVEAEAAEEGANIDLDATRVGKSAVIKTSTRQTIYLPLIGLVDHEKLKPGDLIGVNKDSYLILDTLPAEYDNRVKAMEVDEKPTEKYTDIGGLDKQIEEIVEAIVWPMKEAERFTKIGIKAPKGALMYGPPGTGKTLLARACAAETNATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPSIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVLAATNRIDVLDPALLRSGRLDRKIEFPLPNEEARANILQIHSRKMAVDDAVNWAELARSTDEFGGAQLKAVCVEAGMIALRKGMSKVGHENYVDAIAEVQAKKKDTNMGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPX1</accession>
    <name>B0XPX1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_007865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007865"/>
    <dbReference type="HOGENOM" id="CLU_045150_0_0_1"/>
    <dbReference type="OrthoDB" id="5413281at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="270" mass="29526" checksum="5CBE6F8C8B1EE532" modified="2008-04-08" version="1">MESALEDGHKSLPSSTQFIDRLISQLASCKPEVRDPGDGMDHPTIRPQRHTSTSQSPFSSLPEAQLSQVKSVMLTLHCFFPNELLLALDILDRGLVRRFTRDEHVGQASACSQLDGTDPRNTERPQEDMFYVISTSAAAPTSPSRAPRTRIEQKGYEVRLHAWNCTCPTFTLNTFRDPGPAHSSQFDGEAEDETLDEQSAASDDPTCHYVFGGLLTRGPSRLAPPVCKHLLACLLMVRCPGIFSGGSRGQAGPVFLTREELAARCAGWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ37</accession>
    <name>B0XQ37_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rhomboid family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_008570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008570"/>
    <dbReference type="HOGENOM" id="CLU_026938_0_0_1"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ37"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000012">
        <property type="entry name" value="Rhomboid family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="399"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="568" mass="64045" checksum="ED8B71E2CEA3F5A8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQL5</accession>
    <name>B0XQL5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mago nashi domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_010380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010380"/>
    <dbReference type="HOGENOM" id="CLU_109497_1_1_1"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="PhylomeDB" id="B0XQL5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="154" mass="17904" checksum="64CBAEFB9624E9AA" modified="2008-04-08" version="1">MSNQNEPFYLRYYSGHSGRFGHEFLEFDFRTLGDGRSAAVRYANNSNYRNDSLIRKEMCVSSAMIQEVKRIIKESEIMKEDDSKWPQKNKDGRQELEIRLGNEHISFETAKIGSLVDVTESADPEGLRVFYYLVQDLKALIFSLISLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR46</accession>
    <name>B0XR46_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_012210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012210"/>
    <dbReference type="HOGENOM" id="CLU_148782_1_1_1"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="PhylomeDB" id="B0XR46"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="68" mass="7530" checksum="CFDA154277FC64DD" modified="2008-04-08" version="1">MGGGGKIPYPKEVWSPAGGWYAQPANWRVNTAIMGVAMLGVIAVTWSISAEREHRDRMPEPGRFFPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRH1</accession>
    <name>B0XRH1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_002450</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002450"/>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="PhylomeDB" id="B0XRH1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="20">
        <location>
            <begin position="98"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP55550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="319" mass="35126" checksum="FEDDBFECD6A52898" modified="2008-04-08" version="1">MLARTVLRSVPSRGIARQSLSKTTTRASSSTAGTEAASSPFHLTLTASVATAAAIGSAAWYYSVYGKEAFAMTPAEEGLHPTQYPWEHAKWNKTFDHAALRRGFQVYREVCASCHSLTRVPWRSFVGVMHTVDEMKAFAEEHEYDTEPNDQGEIEKRPGKLSDYIPPPYKNEEAARAANGGALPPDLSLIVKGRHGGCNYIFSLLTGYPDEPPAGAQVAEGMNFNPYFPGTGIAMARVLFDGVVEYEDGTPATTSQMAKDVTEFLNWAAEPEMDDRKKMGAKALVILTGLFALSVWVKRYKWAPIKTRKIVYSPPVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRI4</accession>
    <name>B0XRI4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002580"/>
    <dbReference type="HOGENOM" id="CLU_066899_0_0_1"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="PhylomeDB" id="B0XRI4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="357" mass="42206" checksum="273DBD5A3161FB8C" modified="2008-04-08" version="1">MDRLATELLLHIFRSCESVSDVLNLASTCRRLRRVFNQSHKLQILIDVAEFEFGPLDEIIQLVTHNASQPAHIPRRVPMSESLLRQVVQVGLVARKWEAIYPVKKWKVDFENRRSLTDDERFRLRRAIYRLWLYHRAFHTSNFDRFSRKLRHVISERAQLLHNWSTVELAEVEDIRLIITDIVQNHICPSNGTIQRKFRKRYPESNHQLSFDIHLNYPRTSTPAGLPEWPDKADHTVNHYFYSAHPTSITESPAKYRSRFRNDFFHDPGFEGWGDEIPHYYVVQDMMKLDPGQVLWLREHAPMKEQVEAFIRSLGDWFRDNGETFGDTLQWVMNERGDDIEEFRAAIADRELGIVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS21</accession>
    <name>B0XS21_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rbm25 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_025640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
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                <person name="Joardar V.S."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
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    </evidence>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027670"/>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_1"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="PhylomeDB" id="B0XSM0"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP54706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="483" mass="54726" checksum="B804F6B732349D55" modified="2008-04-08" version="1">MSSSNDVYQTPLNSRYASNEMKYLFSPRNRFSTWRQLWLWLAESQKELGLPIPDEAIEQMKAHLTIQDDEFKVAAEEEKRRRHDVMAHVHAFGQVAPAAAGIIHWGATSCYCTDNADLIFLRDGLDILIPKLAVVIDKLSAFAKQYKDLPCLGFTHGQPAQLVTVGKRACLWIQDLLMDLRNLERARNDLRFRGVKGTTGTQASFLQIFNGDHDKVEQLDELVTKKAGFDSAFIISSQTYSRKIDVDVANALGSFGSTCERIGIDIRHLAMLKEVEEPFEKDQIGSSAMAYKRNPMRSERLCSLGRHLQNLPKDALDTYSAQWFERSLDDSAIRRISIPELYLSADACLILLNNVTSGFVVYPEVIRRRVNDELPFMATENIIMACVKKGLSRQDAHEEIRVLSHQASDNVKKLGKNNDLIERVRRTAFFAPILDELDTLLDPSTFIGRAPQQVEKFTSTEVKKALEPYEEHLLKAETAALYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTB8</accession>
    <name>B0XTB8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_028870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028870"/>
    <dbReference type="HOGENOM" id="CLU_022916_3_0_1"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="PhylomeDB" id="B0XTB8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="145"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="378"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="506" mass="56418" checksum="DD9C16437CE5F724" modified="2008-04-08" version="1">MTESFVDPRMTNVKPRIRYNTIGGINGPLVFLDNVKFPRYNEIVSLTLPDGTERSGQVLEARGNRAIVQVFEGTSGIDVKKTKVEFTGHSLKLGVSEDMLGRVFDGSGRAIDKGPKVLAEDYLDINGQPINPYSRVYPEEMISTGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKPTKDVHDGHEENFSIVFAAMGVNMETARFFTRDFEENGSMERVTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVIMTDLSAYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFVDRQLYNKGVSPPINVLPSLSRLMKSAIGEGRTRKDHSDVSNQLYAKYAIGRDAAAMKAVVGEEALSSEDKLSLEFLEKFERTFISQGPYESRTIFESLDIAWNLLRIYPKELLNRIPKRTLDEFYARSARKLPAKDTRDNSAENVVGAAPLIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTE9</accession>
    <name>B0XTE9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_029170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTE9"/>
    <dbReference type="SMR" id="B0XTE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029170"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="PhylomeDB" id="B0XTE9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="839" mass="93198" checksum="72F3668367F6588C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTN0</accession>
    <name>B0XTN0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_029310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029310"/>
    <dbReference type="HOGENOM" id="CLU_038479_0_0_1"/>
    <dbReference type="OrthoDB" id="3641178at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="403" mass="45141" checksum="A045EDE29147B07C" modified="2008-04-08" version="1">MALSIAKDFIRLETPLSPQSPEQWKQAIQEVKLLYLQRQYKQCAARSFEILEAVRGPIHPVYKTCLYFYSAISYEEMGRAAHNYSRRKLPLLHSALDSFVTCSAILPSTIPVPDNNSESSSPASLVESWTASDFSESPSPVGALVSSITDIIDKSMLCPDDDPFISDSEGWVELALDIPENLPPRMPQDDQRLMPSPLRLRNSSVDLHKTGRQNQPARLCPPPPPLPIKILPADAMEKNPELSGSDRTPRAQGGGNIHADEHKQTPMTPARAESIRRYNSTLESLRVQFSSSIADIHALVDEIRELQSARQASKNFRRSASFWSFSPIKEGPEGREKLGSSGRVIVKETKEQRIARLRAEGWKTVGMRSPVRGWKGAAYYQAYCNSVLDELYLEVQLRVRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTP4</accession>
    <name>B0XTP4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAP domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_029450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029450"/>
    <dbReference type="HOGENOM" id="CLU_063282_0_0_1"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="302" mass="31657" checksum="04359DDDD75383DE" modified="2008-04-08" version="1">MTTDYSKKTNAELVEILKSRSLPHTGKKAEMVARLQEDDQNKAKAATAPAPAPAAKTDAADDVIDWEDDDVPAADTTAVKPSTEAGAAAIAAGGKGAVANPVAVPNQKVDTDPATTNDLKVESKGAAPSAESGAQGHEGTEGAPVEAAPAAPAEEKPAPDYSMGLPITEMEEELKKRKARAEKFGITEESKAAIAEAEKQLERAKRFGTVVHPTPAGGVKGLDEALPTEKSRKRGRGDNDQASRGGKRRDIGGRGKFRGKGRGNRNQNQRNEGNAGKTSGQSNLSEKDRKKQVIVSITGSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTU5</accession>
    <name>B0XTU5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AT DNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_029970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTU5"/>
    <dbReference type="HOGENOM" id="CLU_046879_1_0_1"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="PhylomeDB" id="B0XTU5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="466" mass="52313" checksum="FE6598A3213499BC" modified="2008-04-08" version="1">MSEQEFPLLTWEEVHQNLVLSSRSRSTVPDLLGANKITSLLSASSYLLPERSISPQTATSHPQTHLYGGFYLADPPSGDQQPEAPKPKSSKRTRTDIEPPDGSHSRKRGRPRKTAGEGEDPHEVRQHSSYLALVSILPIKLTGQRRRMQIRLAQRAYRSRKEASVSSLQSRVLKLESAVEQISAAFLSFSDELIQSDVLTSHPRLTLRLRDTVQLCLSLAKGANMTEDQNITTNVSSPSEESHSSSEEKESQRRQSSLATSPPSRESTGSQGLGTLQATGFREPAEDKYPHEAPSLDLSAFIERLHFACLYEGYSALSNTAVGMDVLQRPFRFLLRLMDRKRVASYFEACLHAKASRKRLDEWNEIPYFKIGGAGTHYPRKTKASSNETLPRWENIQDPTSELPQEIQHELDGEWFDIQDLEGFLLEKEVAFVVGDTNSSDKRNVVNAAHLIQGRHLFLLLVFSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU12</accession>
    <name>B0XU12_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_019800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1/sscA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019800"/>
    <dbReference type="HOGENOM" id="CLU_017633_13_3_1"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="PhylomeDB" id="B0XU12"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP53934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="105" mass="11764" checksum="ADC22F929CEDD4A7" modified="2008-04-08" version="1">MASTFAIGLGVATAAFLGRAGYVALRRYQGGMNAMGKAFYKGGFEPRMTRREAALILELPERTLNKEKVRKKHRQLMLLNHPDRGGSPYLATKINEAKEFLDKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU52</accession>
    <name>B0XU52_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_030360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU52"/>
    <dbReference type="SMR" id="B0XU52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030360"/>
    <dbReference type="HOGENOM" id="CLU_045001_0_0_1"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="PhylomeDB" id="B0XU52"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="39537" checksum="0D2AA0B8821F0F95" modified="2008-04-08" version="1">MEYPPQYQQPHGQHPHAPSHMAGPYQTAPQNAGSTVGSMSSPTNPQGHMQQPHPAHQGSSIVPSQSHYQQAQNAPGSVHQQMNFPQSYGVPTAMPQPYGISPTQAAAMATAAASGQFYPLHQDSMAGQMAQGPRGSPRMAGVQVKGDRNPRSPPQISGQMPPMGTQLSMSQNAQMQQRRMSHVGSPHVQTAQPVLNHVARSSVPPPMAPPPQPVQQSQPSPELVAGAAEESPLYVNAKQFHRILKRRVARQKLEEQLRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTADEVAAMEKKQAATAAGSGQENVDSGKPAEENPSSAPKRKSSEVNDDNANSVKKSKTGGATRPAEESERESAEPTDEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUD2</accession>
    <name>B0XUD2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_020320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020320"/>
    <dbReference type="HOGENOM" id="CLU_102594_0_0_1"/>
    <dbReference type="OrthoDB" id="4469984at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="198" mass="22912" checksum="ECB9EBDFB835BBD0" modified="2008-04-08" version="1">MFLRGSKSEQTRELHEPDSELDVFFDLILHTMIIREITKDPKTRKTFRVTYLKIDAQSVHFINMHGLADNSLLLSLRVRESLCAVKGHKMQMRVKHFGFRPMEDSKLYTDVYCCDWSEQNIEILLPGKRIHEWKTVALILATFHRISKEQWCLLVNMAGAPGIVGLNWKVIESELWPEKSEPDDIEAAEAKSVDTVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUK9</accession>
    <name>B0XUK9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfite reductase beta subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_031250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031250"/>
    <dbReference type="HOGENOM" id="CLU_045565_1_0_1"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="PhylomeDB" id="B0XUK9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35112" checksum="DCCCFE7CDF45A499" modified="2008-04-08" version="1">MDDSDPVIASYDVYLTDSEISRFVLQYLDRSAEHPYDERHEQKPTAFRLKPNTGLVEVDVPIQTRVNYDVSKGLRYGDAMRRSRSARDGGSYGLAGGFSSGAAAGGGKVKMEGNVDVEMAGMDSKEGSDIMRVQTLGGRIKGPEDGDPVYMLAAFRGQNLHLSPVSAVVQLHPQLHHIDALDEIPAKGRVKARKEGEEEQTEARAIDVKIKAAEDAEAAMVAGNLELLKKMQDEKWTMYEWVDAETEEAWQTYESYMIQQDLENVPQLEAAIDSEDYLDRMSAPRIDPARPEMTGWAMKQNRKRQKEQASINAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUL7</accession>
    <name>B0XUL7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_031330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031330"/>
    <dbReference type="HOGENOM" id="CLU_112964_3_1_1"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="PhylomeDB" id="B0XUL7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="111" mass="12581" checksum="0D258AC2F9702251" modified="2008-04-08" version="1">MSAQAYYELYRGSSLGLSLTDTLDDLINEGRIEPQLAMKILSTFDRVITEVLADKVRARLTFKGHLDTYRFCDEVWTFLIKDVTFKLDNQATVTADKVKIVSCNSKRPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVN0</accession>
    <name>B0XVN0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_033020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033020"/>
    <dbReference type="HOGENOM" id="CLU_2867253_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="64" mass="6723" checksum="A8052D08F69F0235" modified="2008-04-08" version="1">MSPISSNAAGKGCSGTGRISRRARCSMFARLTGRLVVDAKCADNEAAAAGVHRDWRGLVGFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVN1</accession>
    <name>B0XVN1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS monocarboxylate transporter (Mct), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_033030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Proton-linked_MCT"/>
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        <property type="entry name" value="Sugar_transporter_CS"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
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        <property type="entry name" value="MFS_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="43"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    <evidence type="ECO:0000256" key="5">
        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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    </evidence>
    <sequence length="441" mass="47766" checksum="02288BFFB11A581F" modified="2008-04-08" version="1">MRVTSLEKGLGPAIEVKHDVAAATANKTSEEESTAPMDHGLHAWTVVAGAWCCLFCGFGWVNAIGVFQDYYQHNQLREYSASSISWILSLEPFVLFAAGIVLGRVFDNYGPKWMLLIGTFLHVFGLMMISVSSEYYQFLLAQGICSPLGASFVFYPASACTATWFDKRRALAFGIMSSGSSIGGVVFPAMLSRLLPRVGFGWSLRISAFVVLALLAVANMTVRSRIAPVPRRVQFSDYIGPFSEEPFVLLMLASCCGFWAMFVPINYVILEAQEDGVRRSLAEYLLTILNAASLPGRILPGYLGDKLGRFNVMIAMCTLSALTILVLWIPGTLLAPGSAAVYVIFSLLYGFASGAFVGMVPALLSQITADMSKTGVRQGVLYTCMSIATLTGSPIAGAILNRQQETYWGLQVFAGAMMVGSVVFFVAARVVLQGTSLRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW99</accession>
    <name>B0XW99_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Involucrin repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_024070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="entry name" value="Woronin_anchor"/>
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    </dbReference>
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        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
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                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
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                <person name="Fraser-Liggett C.M."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
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                <person name="Sundaram J.P."/>
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                <person name="White O.R."/>
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                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036620"/>
    <dbReference type="HOGENOM" id="CLU_038797_0_0_1"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="PhylomeDB" id="B0XWW2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="10">
        <location>
            <begin position="216"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="428" mass="46273" checksum="16BA559BEFF1CD31" modified="2008-04-08" version="1">MTSSEKVTYVPAGEIDKVFAHTTNLASSGLNTKILACSDEFFAAASNLLTPTPPINRPGVFVHTGAWYDGWETRRHNPEPYDWVVIKLGVASGAIQGVEVDTGFFHGNYGEKAELQGTYAPVDSGVTDEQIADPSFNGWTTILPPQPCGPSQRRAWKLNDYDPSNPKPYTHVRLLMYPDGGFARLRLYGHAIPPPAPEHINSAEAPIEELSSALLGGLALSASNQHYTPISNLILPGRGKDMGDGWETARSRIPGYTDWAIFQLGLPGSVAKIVVDTKDFRGNFPRAVRVHGLLEGSVAAGEVPAHDHPDWIPLLSGDKFCKADTEHVYEGAELAAGGEDTRTFTHMKLTLIPDGGVKRFRIFGQKGDDAAIENGSDSGGRILSPGAMGITKYCIEERRRKNASKSGSQTVLIIARVAGKFQPITQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXH7</accession>
    <name>B0XXH7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II Aldolase and Adducin N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_048370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048370"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="PhylomeDB" id="B0XXH7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="294" mass="31932" checksum="F6C66E9CFCB6A02B" modified="2008-04-08" version="1">MTTTAVTQSIEEVGHSISAVAEAPKQAVGAQAALATGGYEFPGIPKFDDPYKKRQWQLEHMAGAFRVFARKGFTEGTSGHISVRDPVDPSTFWINPMGKHFGMLKASDMVQVDENGQVIGGNKTAVNVAGFMIHSAIHRARPDVNAACHAHSPAGKAWSTFGRPLDIINQDTCNFWGTQAVYNSFGGVVLGAEEGNRIADSLGQTGRVMVLQNHGLLTTGSTVDEAAYLFTLMERSCEVQLMVESTGLPKKLIGQKEAEFTARVNADPETLYTEFQPDFEYEIWKSNGELCKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYH1</accession>
    <name>B0XYH1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_040900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040900"/>
    <dbReference type="HOGENOM" id="CLU_048148_0_0_1"/>
    <dbReference type="OrthoDB" id="4225223at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="478" mass="52956" checksum="CCB38D14B82225F1" modified="2008-04-08" version="1">MLSPASLAYSRQAPPVRPSRSLEGLEQVIPPRVPQPPARPTLQLDKPLPDLPSQIQSLPDASEMRGSTAWSDDSSTISSADSDGSQDHESTHSTESYPVFVRSASDDLPGLVDHPPVSSLDRAEPIVDPCAKQSTIASYSPSLSLSQHALSVSKDDRYGSPPEWAQKRAGPNHYFREKKWDFFPELATPSALGAGPSGRVPPASSQWRKRNAGKLHLSSFDFGRNRRRSNTSDRGTLTLAHEVRDSIRSYVHRTLSRRSAEKDKPNRRGRPTTAPSFYPPKYASSQGTATSSDHPHGTSTEESSPMDIDIRMRTLSISTDSSMSERWVESPEPIPVHRTKQLAVPITPYQKYGAAIWDKSGGTKRVSYRPNQQVKFSKHQRNIYPSSAQKSKSSTDFTSANPTAPLSPPVRSVIQQNTREAIRVLQDGTTQVLDVLDEAKKKVIKSSDDRRRMQLKSQIKLIGPVNPYTTYGRVESWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYN9</accession>
    <name>B0XYN9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1275 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_041570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="B0XYN9"/>
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    <dbReference type="HOGENOM" id="CLU_061825_0_1_1"/>
    <dbReference type="OrthoDB" id="5223589at2759"/>
    <dbReference type="PhylomeDB" id="B0XYN9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
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    <dbReference type="PANTHER" id="PTHR37488:SF6">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G07550)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1275"/>
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    </dbReference>
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        <location>
            <begin position="60"/>
            <end position="80"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="257"/>
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    </feature>
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        <location>
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            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="296" mass="31966" checksum="E482E5AE75E9C67C" modified="2008-04-08" version="1">MAFDDLPQLDDSKDRPGLWSAGNSTAVSLQPTDEISGPEGVRSILIRHFSADINTKYTDLLLIVCGFVSGLVDGLCFNAWGSFASMQTAEGNTVFIALGASGQPVYPAYLWAKSLAAVAVFILSMIVHIYFSRLLGPRRRSTLILSFSAQTLALMAAAILVETGAVSRRAENPRAPIQWMQILPISLLAFQAAGQIVASRILAYDEIPTVVLTTLLCDLIVDKDLLARGWTSNPRRNRRVGAFLALFLGAMTAGGLSKVTDMAASLWFAMGLKLGIVIAWFVWKAEGSRKQGKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYY1</accession>
    <name>B0XYY1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_042480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042480"/>
    <dbReference type="HOGENOM" id="CLU_393844_0_0_1"/>
    <dbReference type="OrthoDB" id="4219928at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP53077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="667" mass="74392" checksum="EA0275A140EDE0CF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ06</accession>
    <name>B0XZ06_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">AFUB_042730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0071821">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000105">
        <property type="entry name" value="Inner kinetochore subunit cnp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF5">
        <property type="entry name" value="CENP-T_HISTONE H4 HISTONE FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="372"/>
            <end position="479"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
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            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="480" mass="52648" checksum="D3A027AD163B62FE" modified="2008-04-08" version="1">MSATPRPHGRRPSRDTTASDSNANTPAGETTATRLQRLPIHTRYPLTPSRLAGSTTPSANPPVSRWTPGRRLTNAPSTPYGLRAMQRRAANTPGRDRRKSGRIQRETTFDILRNLGKALAPISQPIRSSPQEKLEPTPEPEKEKDEIEELDNEPELERPRLSLPLEEVEEVDEGSPEMRPPRLSLAFDEEDITHTSVEYPRRATSEYDRARLSMMSYGNPRLSENFGDSTRLGSGSEGGEDDDTGMEGDGPDDTMISQGAFDRGGETEDLGRFNFEFNFPSPPPPGEGDLMQDEPLDDNEGFELPPVDLGPEIGAESDMSDSDVGGGAGDFGLELNMPSRVSLSQSPGLIGGGLRDEDSVLPGAKQKKLSHHGIPVPNMPVGVVRKLATRFARARAGSKTKISKATLAAIEQASAWYFEQVSEDLAAYSKHAGRKTIDETDVTTLLRRQRHINNTTTVFSLAQKYLPKELLQDMRLAMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZM8</accession>
    <name>B0XZM8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_044600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZM8"/>
    <dbReference type="SMR" id="B0XZM8"/>
    <dbReference type="HOGENOM" id="CLU_016061_0_1_1"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="PhylomeDB" id="B0XZM8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="727" mass="81555" checksum="590559F08D633AB0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZN4</accession>
    <name>B0XZN4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyridine nucleotide-disulfide oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_044660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044660"/>
    <dbReference type="HOGENOM" id="CLU_003291_1_2_1"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="PhylomeDB" id="B0XZN4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF1">
        <property type="entry name" value="NAD(P)H SULFUR OXIDOREDUCTASE (COA-DEPENDENT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="490"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="580" mass="62940" checksum="681777F62559E596" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y007</accession>
    <name>B0Y007_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lysozyme inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_045200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y007"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045200"/>
    <dbReference type="HOGENOM" id="CLU_153989_0_0_1"/>
    <dbReference type="OrthoDB" id="3497702at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758084" description="C-type lysozyme inhibitor domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="12885" checksum="ADE5C6AE19B903C7" modified="2008-04-08" version="1">MKLSSNIALAVAFLTSSLSATASAEAPLVTVQLANDQSGANANVAVRADGVKHTVESLWGKTAVARNGIVYASSTQLTAFQQNTACRISQPGIDVTLDARHTWSWLDGGRVVDLNGASLVCKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0X8</accession>
    <name>B0Y0X8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_058900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0X8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058900"/>
    <dbReference type="HOGENOM" id="CLU_010101_1_0_1"/>
    <dbReference type="OrthoDB" id="4152802at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="790" mass="88785" checksum="30E95E114FB96BCE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y186</accession>
    <name>B0Y186_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_049050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y186"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049050"/>
    <dbReference type="HOGENOM" id="CLU_028539_0_1_1"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="PhylomeDB" id="B0Y186"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF63">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="128"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="423" mass="47696" checksum="961713BA8B1E80D2" modified="2008-04-08" version="1">MLGWRENGSSIMRPLQRIVFILSCSFLIYLAIRLRAGGYAPGSPAPPSFPGDKGPTEQSFGNLSWTQAQCAAAFPGLFDEIEDAVSRGPFPLTWPRLGEPLQGRIKDNQERTAALNQLYRAIVTSPEPLPDTVFALNIQDRPMAQSWSYARPADPTAAKAGSFLMPHFAFWAWPLKYIGSMHRALTAITEIETKQTFQAKIPQAVWRGTPWFNDVQNHDLRKRLIRVTTGKPWADVQSLKWETNGQTASNGLAIEDFCRYKYIIYTEGVTYSGRLLFHQACRSIILTPPMAWMLHTTHLVRPVFSSTLLQTTPSWGPPNQSDRIQRAWPTDLSAEDANLVMVSPDWSDLEATIAWLEDHPTMAEGIADRQRQLFHDGGYHSPAAEACYWRALIRGWSKVAEPEGREWSEHEGVRWELFSLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1A7</accession>
    <name>B0Y1A7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_049260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049260"/>
    <dbReference type="HOGENOM" id="CLU_136888_0_0_1"/>
    <dbReference type="OrthoDB" id="4905085at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758123" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="120" mass="13280" checksum="B7BC93F9ECDB43DD" modified="2008-04-08" version="1">MQIAALAATFALALVPSVSAWRVYFYQLKEGEGPSITNAGPGNPGFRCHPNVDPLNQKISSMRYYSDNPEGTTRCCLRVYDSPGCKGDFGYSFCRNQFLNFADIGHDNDVSSYSTECFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1E1</accession>
    <name>B0Y1E1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_059960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1E1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059960"/>
    <dbReference type="HOGENOM" id="CLU_1128825_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758535" evidence="1">
        <location>
            <begin position="25"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="246" mass="26263" checksum="EACB7296BD842CBF" modified="2008-04-08" version="1">MSVWTGMQLLSLVTLLVRLNGVSDQTYETGTKLLSSHSCSDSLHHVSDRSIRGETASRTTWQVTVVIRAVSGDGHPSIPHWNTLIVPATHHLFPFPPFFFDFPPLAPVSALLAFALAASSTTAGASVISTSVATAEAVVVGAGADSPSPAAFAPPANFPRLVTSRPTSAALFVRYFRQMPAVGLYVFRVRTATGVVAVRAGESVVSGFDVEEGFFCAEGRCEGKPYFVVMRVCVVCIGGLWVRFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1S5</accession>
    <name>B0Y1S5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BZIP transcription factor (Atf21), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_060680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1S5"/>
    <dbReference type="HOGENOM" id="CLU_888511_0_0_1"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1S5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="163"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="328" mass="36637" checksum="E21938003674A1CB" modified="2008-04-08" version="1">MLPEQSAFGRSAMPGSDAVNPGPSPFAPPPNSFSGDFLGLSLPDEEHLWGMSPLSSSMPSWNGKNEQMFSNPNLERDLKHSHVRNGQPTPPPYGDNKTHTVGDLYSLSQCQFSNGAQNFQTHNDRRSFCEQSAINSNGGSSKRRKVRDAKMTQAEYNEQQQEKAKREKFLERNRLAASKCRQKKKEHTQLLESRYREQSDKKEQLVSEIARLRSEILGLKNEVLKHAQCGDEPIKLHLAQMVKKITYNDTTAPDLTDVPDAASSSEGPMTPRPQQALSFGFDDPLHLEPSRADGSTDHSVRRDSEASVLTENSYAFSTDDSFDDLINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1W2</accession>
    <name>B0Y1W2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 2C, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_061050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061050"/>
    <dbReference type="HOGENOM" id="CLU_013173_9_1_1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1W2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="138"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="557" mass="59920" checksum="B2C7C2B605BBEE9C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y247</accession>
    <name>B0Y247_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3'-5' exoribonuclease (Csl4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_061230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y247"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061230"/>
    <dbReference type="HOGENOM" id="CLU_067135_2_0_1"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="PhylomeDB" id="B0Y247"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000057">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000164">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="5">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="249" mass="26853" checksum="E5EDB0CE39A75C2A" modified="2008-04-08" version="1">MASSLPSLAIPGQRLGPVSSYSAGPGTHVQNANIYASIAGPVVLQQAQPSSKSKSILSVSRNLPRKTDPSTSTTPVKATTTTKPKLRYNTLPAVDSIVLARVTRVQKRQATVSILVVLDESAGSQDPDPSKTASDNDNIVSILASAANPENHSNSDELRFQALIRKEDVRAVEKDRVVMDEMFRVGDIVRGSVISLGDQSFYYLTTARNDLGVVMARSEAGNMMFPVSWKEMRDPVTGAAELRKVARPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y270</accession>
    <name>B0Y270_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_061480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y270"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061480"/>
    <dbReference type="HOGENOM" id="CLU_013173_1_4_1"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="PhylomeDB" id="B0Y270"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="316" mass="34176" checksum="23476D00EBFBB307" modified="2008-04-08" version="1">MGPLSSSASGDKLALKDAGGNSALGSRPSQQDQYTILLPAQIPFKTEKTLLFLGVYDGHVTSDVSLHAKQHFHRLILESPDIQAGSYEKAIEGAVQKEDQLLLDQFRAGNEVFGKSGSTFSVCLVDLTDGVLVVGNLGDSHVLLGEHYPNGWEVQRITKAHKPGSDTEKERIKEAGGVVNRELGSPRIAAGALNMSRALGDLQYKAPLINADEPFSLEQEIAGFNPDKEQGDLLSNRPAISRIELKEDRKYIVILTTDGVTDEMEDRRILDQVVAHWNYGTRAEGVAGKITTEATGGPMSDNATCICAFIYGRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y279</accession>
    <name>B0Y279_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_061580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y279"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061580"/>
    <dbReference type="HOGENOM" id="CLU_037162_9_0_1"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="PhylomeDB" id="B0Y279"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="167" mass="19072" checksum="8D5B40D4D7374075" modified="2008-04-08" version="1">MMNPRVGVGVVVLNNEGKVVLGKRKGSHGAGTWAFPGGHLEFGESFEACAVREVLEETGLSIHDVRFLTATNDVMEAEGKHYITVYVGARVREDKGQPQQPQIMEPEKCDEWRWISWEDVRSWFNKQVQTEGMETRDDQPKLFIPLFNLFRQRPTFDPKKSYDSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2G3</accession>
    <name>B0Y2G3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IgE-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_051350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2G3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051350"/>
    <dbReference type="HOGENOM" id="CLU_078556_0_1_1"/>
    <dbReference type="OrthoDB" id="5430620at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2G3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052820">
        <property type="entry name" value="PhiA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760383" description="IgE-binding protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20438" checksum="5A1B360E2FC44718" modified="2008-04-08" version="1">MKLNTVLSLAPLLGAATAQGQHEQEPFTLNVRWSNSMGTLEGLLNANSGAFWSGKPTVSSCPENVQDCPAVNTTSFVSQGSKLFLNVAVPGGQQVYISPEGQLTYTVPHSGYIPDGSLADLPIMKDGFLNPFLTLWLCSVDKDAKQWKVWAEYTNGTTGAITNNGSNGQSACTRFALEAQPYKGDKAWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2M0</accession>
    <name>B0Y2M0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_062300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2M0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062300"/>
    <dbReference type="HOGENOM" id="CLU_2060978_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="119" mass="13015" checksum="938F6B27E3E339D7" modified="2008-04-08" version="1">MTMSVERSKQEGHCGQECKKAYGPRAGRLGIECLVSNNRVIISRLALTGDLGVLMGEIAADSMHHIREMEMNQQAIVLQVAAGFVLFFNAWGMINTLAVFQTYSESGELFKASSCRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2M6</accession>
    <name>B0Y2M6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphorylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_062360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2M6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062360"/>
    <dbReference type="HOGENOM" id="CLU_049915_0_0_1"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2M6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="155"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="273" mass="30275" checksum="C69FD44187F6A11B" modified="2008-04-08" version="1">MDYDALLARFDDLVAREIIYYFPPTTIRLNDAGFASGDSASPKGFGPGSDIANTDPNLVITIINHTHLLVINKFPVFRPQLLLLTCDSYRRQHEPLTVEDFAAIQSVLSSSKERHLVIYNCGPIAGASRNHKHVQILPRPAHLFPDDPNCDPEWIPFRYGLRYLGGPDFEDPEYPSQLSASYQELLAEAKGSPGSSADSNNAGYFPHNVALVREWIIVIPRCSNNFKAISANAAGMMGSVWLKSEEELDRWKQVGLSKALAGLGYPRESEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2S1</accession>
    <name>B0Y2S1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_051750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2S1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051750"/>
    <dbReference type="HOGENOM" id="CLU_023861_0_0_1"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2S1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901524">
        <property type="term" value="P:regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="52"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="268"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="441" mass="50571" checksum="47AA8CC9575032F6" modified="2008-04-08" version="1">MQRNQPFRCWHALRLSCKPRVRFYSGVDNSHSPPPWRPGSVLDEWVEREIRPISLRQLTFFGRTLTESRLISSANYVRTELPTRIAHRLRDIQKLPYVVVANPHLSLVYELYYKAFERFRVIPEIKTLEDNERFCDILRKTLKEHLVVIPKLAMGVLECRDLVAPGVMDQFMNTLLRSRISRRVIAEQHLALTETFSSPWHFPGSQDRTDMNADFVGEVFLKCNAKEVIERCGKLAQDMMRQSSGTDKIPEILVQGHLDATFPYILSHLEYIIGELLRNSIQAVIEKYKESSEKPPPIEVLICEAPQHVIMRVSDQGGGIPREVMPYLWSFDKGPLSKSRLQNLKQVPAMAATMQELTVSKERKHADRETYREGSLDSLTSRPPNLRLGIGLPMSRVYAEYWAGSLELHSLEGYGVDAFLQISKLGNKNEQVTTRASIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2W5</accession>
    <name>B0Y2W5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_062600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062600"/>
    <dbReference type="HOGENOM" id="CLU_2276842_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="102" mass="11616" checksum="D646FA2184362736" modified="2008-04-08" version="1">MACYITCLSTCLTSQTYLLACLTSLSTCLPDWFDLPNLLDLFNLPDLVDLLDLLDLLNWFDLLDLLDLLDLLDLLDLLNLFNLPDLVDLLDLLDLLNCWLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2X1</accession>
    <name>B0Y2X1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_052160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2X1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052160"/>
    <dbReference type="HOGENOM" id="CLU_760705_0_0_1"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="364" mass="41537" checksum="B44F595EEE1C2CA5" modified="2008-04-08" version="1">MRYLFSFSSCTVNTCEQVFNVNSPFLCLLLCRTAFACCPLFKMSDKIEEISEIEEPAQSQSEENGASLTRRTHVQRVEHPMSELDSNNGDAWTCDEETYRRGGILIPVEVPNDIAPSDNVDVRSAKLIFLFGPPAAGKSTAAANVSAELGCIHICPDQTIKRLGKTGPYLAWLRVVQAIETEGSVPPELLFRLVKMEIQRHMEFGATTFIIDGWPHCSEDFTQLHETFTIVSAFHLYATQDTLEKRAMQNPMTFDEGTKCLKSFRDGMVRYYQELGDLLTLDSFKDVLIPVRIQPHFQEYDRIHRLTPYEMSAEHDYQVFYPQIKFIIEERLARVEAVPELEQIETSSDEHEHEPEPVGDENLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y354</accession>
    <name>B0Y354_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_052990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y354"/>
    <dbReference type="HOGENOM" id="CLU_150777_0_0_1"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="PhylomeDB" id="B0Y354"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="125" mass="14587" checksum="30F6892C4B15BB7D" modified="2008-04-08" version="1">MALLLRYLADDLETQCRIFSLNFNPQRLRLGNKVLRQRLRGPALAAWYPRKTVSFRDLQDAYRPLGLTVFDEYEDDREEAIQMYVIIHTKDKTLIADYASAKLRGKGRPKKKRTAAESRSAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3I0</accession>
    <name>B0Y3I0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_054270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3I0"/>
    <dbReference type="HOGENOM" id="CLU_030117_2_1_1"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3I0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="23"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="480" mass="54146" checksum="F4509ABB0BF094DB" modified="2008-04-08" version="1">MEYDPKIPQYLTSDPSSFGYVSARERWPVIITSAIDDLHRTVADVIDEEKRKEGKVIIEELAKLKYEIQHDRKLTPLPDDGEPGIAEYNQELEQRGTPSWQNASWLFSECYLLLTKTDRRVSTLFALSKNWKGYDVFSRQKMSTFKSSRPAVLELAARYHELALQAQKGKGVDGKAVEEIEEAERLLFSEMCEICLWGNATDLSLLTSLTYEDIQKLQGSKARKAAEENILINDLDAAFDALAKAQKEKKDGERRVDIVLDNSGFELFVDLILAGYLLSAGLATTVVLHPKVIPWFVSDVTPRDFMDLLNALADAQGFYTAPDETGREYEPLSEKELAEVKFLFDQWSKFHSEGKLVIRPHAFWTAGGSYWRMPYVAPDLFEDLKQSELVLFKGDLNYRKLTNDAAWDPTTPFTTAIGPLGPSSGIRILSFRTCKADVVVGLKPGEDEKLRETQGGDNPKARKWAWSGKYAVISFCDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3J0</accession>
    <name>B0Y3J0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_054370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3J0"/>
    <dbReference type="HOGENOM" id="CLU_030047_0_0_1"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3J0"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP51431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="600" mass="67353" checksum="1328D4BB14EA7194" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3Y4</accession>
    <name>B0Y3Y4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-actinin, sarcomeric (F-actin cross linking protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_055850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055850"/>
    <dbReference type="HOGENOM" id="CLU_005217_0_2_1"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3Y4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="645" mass="74491" checksum="00E1D9161210BD3A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4A8</accession>
    <name>B0Y4A8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_057100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057100"/>
    <dbReference type="HOGENOM" id="CLU_030898_1_0_1"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4A8"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP51699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="554" mass="62788" checksum="FBFAEDFFF95D1A9D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5A3</accession>
    <name>B0Y5A3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_071920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5A3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071920"/>
    <dbReference type="HOGENOM" id="CLU_008719_5_0_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5A3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="482" mass="54394" checksum="CD89147BAA03DB91" modified="2008-04-08" version="1">MSNLVGPGRRPAETATPHLEEETILSPGTISSSDEYAANPRFLQLQEELRDVLFTAVASHVPTRHESLRPSDPIEDSASGLLRNSLDFAQVSIPKVRLIHYLKNWIIECAPHLDKFDEQSHFGVHIPVLAQSSPALFYAILAFSARQMERKACLDKSYDSLELYQQSIRLLTPYLQAKDPNVLVTVCILGCLELMSVSPRDWRRHVEGCAALFDAYNVNGFSGGHLQAVFWCYARMELCGAIISEGTEGTILPLHKWVPPQAADSEEERDIMIKNLFCQDSCSNPDRHANWAVYLCAKTCNLACRRSRFLELGELDQNDTRPFSEQWTRLWEELQFWNDHRCPAMLPIRTTTTGGDQIFPEILFAHWAAISGNQLYHTACIMMLQMKPANIPLAAPTPHSSPVWHARRVCGISLTNPHSGNLINAIQPLYIAGKLLSHRSEHLEVARLFKKIETSTGWGALWRLRDLERAWGYETGEILSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5E0</accession>
    <name>B0Y5E0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_063070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP49975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063070"/>
    <dbReference type="HOGENOM" id="CLU_034879_2_1_1"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5E0"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP49975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="419" mass="45658" checksum="9A93B9CCE4D469FF" modified="2008-04-08" version="1">MRLQFSYLPPVRLDQLSRRYGSGSSLLNDKRHRLLCNRNSLTTSSRVNSTGRQSAYTAKPRSAITKRTSLMRCQPHSSQSPSSTDRPAAITDNNPATHYIPPQKGFIASLPGSWIPYAELIRLDKPTGTYYLFFPCVFSTLIAAPMASATPMQILGTTGLFFTGALIMRGAGCAINDLWDRNLDPYVERTKFRPIARGALSPKKALVFTCSQLLAGLAVLLQFPSQCLWYGIPSLLLVTTYPLAKRVTYYPQAVLGLTFSWGAIMGFPALGVDLFSNHAALEAAAALYSSCVAWTVLYDMIYAHMDIKDDVAAGIKSIALRHEHNTKTVLSGLAAVQVALLATAGVAAGAGPLFYVGTCGSAAVSLGIMIWKVQLKNVKNCWWWFKNGCLLTGGGITLGMFFEYIAQTTGLYKSDNNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5J2</accession>
    <name>B0Y5J2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_063580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5J2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063580"/>
    <dbReference type="HOGENOM" id="CLU_039068_3_0_1"/>
    <dbReference type="OrthoDB" id="61390at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5J2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758222" evidence="1">
        <location>
            <begin position="25"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="380" mass="42451" checksum="AF007E39AEBC61FF" modified="2008-04-08" version="1">MGNFISLFLKGLIFPLKIIVKITARVIDLLEGKELYGLDHAILSVEVPPAKGMWMNMGYWKHTSSFPEACEALLEQVLITAKLLNEDRTPITFDADNDFQSEPFIHEMKLVDVGIGCGDQSLYLTRRLSRKAGIPTASAGGMREASSVRPLFDSYVGLTVVKSQAEFARERLSQVRSTTDLAGASEETTDVKIFAANAADPSSWESSLHRAVFGQSVKGEPIQECPKKTQTWLLALDTLYHFQPSRDRLFKCAYQDMQASIMAFDLLLSEHATLWEKFVLRLMCLVAGMPYGNFVTKTGYKQILKHAGYESTLIEMRDISEHVFPGIARFLRKQDAELSKYGMTIGRYKGAANAFDWWGQTGVVRGVIVVARRSENLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5W1</accession>
    <name>B0Y5W1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">INSIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_064770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5W1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064770"/>
    <dbReference type="HOGENOM" id="CLU_039316_0_0_1"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5W1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37834" checksum="5D3924D221548B09" modified="2008-04-08" version="1">MADKPAILQPRPRRVFDLTPASNESSESPTPAEPANSDLLNPKEAASSSVSRTASIMNLTSSTLYGIYSPTAFEGEGQTPISESPPIIKPSPDTPVRQSLQRTRSRLSHGLFRGVILPQVFRSVLLFGFGVAYGVITVHLHENHWITPVKLENIRYYDSWQYLGLWGLAGVALGNVLPWLDSFAGEWNTDRSQTVKGQENNRLREDRTPAWVIVARSVGAFVGIAFALRRLPWESTTQASATLALVNPVLWYLIDRTKAGFLLSTVVGLAGTGVVLGLKPELVPASADTPATTIPLLNGTVLEYGLPTGLTQEGVSVRIWLASVLFCACVCFGNVGRQLAIGGTGRDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y649</accession>
    <name>B0Y649_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein Ral2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_065660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
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        <location>
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            <end position="896"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP50234.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="896" mass="95914" checksum="EF780E2B70D56B47" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y690</accession>
    <name>B0Y690_ASPFC</name>
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        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
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                <person name="Sundaram J.P."/>
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                <person name="Youngman P."/>
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                <person name="Wortman J.R."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="12"/>
            <end position="29"/>
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            <begin position="141"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23443" checksum="37DCC5FBA531A6B2" modified="2008-04-08" version="1">MIGSLFFIFNRLVEIVFLIPIIGMMAYFVDGYLKANQITPPYILVLFIVSVIAVFWAFDTLIRHSTTKRSAFFVAFVDLLFFGAFIAGVYQLRFIANADCAHWNGGSVWVSLGPFGYLGYENQNHLYLEINKTCAMLKTCFALGIMETVFFFWTAILALFIYRRDREVVVKETTTVRRRSHSSRRGHGHKHRSSSRSRQHYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6F0</accession>
    <name>B0Y6F0_ASPFC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">AFUB_066700</name>
    </gene>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </feature>
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        </location>
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        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="166" mass="17858" checksum="E85A44B1D6C1CEC2" modified="2008-04-08" version="1">MSPSLQLNTPSPGDEKLPSCSSKTLVAAPPVESPKSPEDYDPCANAKPYSPFYRHATTSFALEQSKSQSKKPNCTVDGMNDLESAPSQTPYKPSMDVPGCRNSKLWTKKRKRCDCMQALTRKQRMIVKAAIAIVTLGSMVAIALGITVAVGGGVWKSDRQQGAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6K0</accession>
    <name>B0Y6K0_ASPFC</name>
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        <submittedName>
            <fullName evidence="7">Homeobox transcription factor, putative</fullName>
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        <name evidence="7" type="ORF">AFUB_067230</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EDP50385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067230"/>
    <dbReference type="HOGENOM" id="CLU_038392_0_0_1"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="173"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="274" mass="29910" checksum="0AA15CDFABE6072D" modified="2008-04-08" version="1">MSQHGEVDDESGKMAISYASGLSADHTQSLPSFRETRLPGNGVQSAAARGPSPILPSIRDLQAIPDCSLKAPATGLPDHRGPSRTEAYPVQEFRGGAVGAPSYSPTGLPGSMGDRRDLYAGNSIPAAVHAQPQYPSYPGVIYQSDSEQASSQSLPPSQQSNFGILGNSVDSKNKRRRGNLPKPVTDILRAWFHEHLDHPYPSEEDKQMFMTRTGLTISQISNWFINARRRQLPALRNQMRNGASDLDSQRQSPFSDMEQTSSEAPNRLNSTTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6P0</accession>
    <name>B0Y6P0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_067630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6P0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067630"/>
    <dbReference type="HOGENOM" id="CLU_054584_1_0_1"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="407" mass="45611" checksum="70C0904CF83070D8" modified="2008-04-08" version="1">MIPPCDPIILENNPQFRKLYQHLTTNLLNADGSTRANDEQPARKAVLEELRGCRVRSANKKIKQQILQQLAFDADSGLPDDYRDPLAVITLYLESSPSRLDLEDGDDHRSSHDQALSLLASDIDAFYSIIPALVIPFSNALSSALEDLRAIAHAGKSLDCAASAPAIPHTSTLPTRTRIRTSRNQFKAKSQAPLASQLRERLQKLRQIQLAQIPAARARMAITAAKVLETRAEILKHTVVLLERVKHGALSRATKSKAEHLALVAQGVEAKLRIIKLDTAAILYTPEVVTALDRYRQHLRETRERLEEKQGKLLEELKGYESMDSTETHELSARSSKEHFESGPMREIARRYGSLVKEIEAVKLEIQRIKLQCYAPKPATGKVPRTQSPEWWPWPLSGSPRSHDPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6V0</accession>
    <name>B0Y6V0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kynurenine aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_068220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6V0"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_1"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6V0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034276">
        <property type="term" value="P:kynurenic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000263">
        <property type="entry name" value="Kynurenine aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="40"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="212"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="448" mass="50320" checksum="4491BC4E22DD36CD" modified="2008-04-08" version="1">MSATAARPDPFRPAKRVAGQRQDVWSIVNEAAAASPVQPIVNMGQGFFGYNPPQFALDAAKEALDRVECNQYSPTKGRPRLKKAIADAYSSSFGRTINPDTEVSITTGANEGMLSAFMGFIEPGDEVIIFEPFFDQYISNIEMPGGTIRYVPLHPPKDGATRTSPASEWTIDFEELEKTINSKTKMIVRSFELTVSEPGQLHPYGANNSIRHNPVGKVFSRDELERIGQLCVKHNLIILSDEVYDRLYYVPFTRIATLSPELWERTLTVGSAGKAFYATGWRVGYLIGPEHLIKYVAAAHTRICYSSVSPLQEAAAVAFEQADKVGFWDQSRREMKQKMERFCEVFDELNIPYSDPEGGYFVLANMSSVKLPEDYPFPPHVASRPRDFKLCWFLIHEVGVAAIPPTEFYTDANAHIAEDYLRFAVCKNDDVLETAKERLRGLKKYISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Y3</accession>
    <name>B0Y6Y3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Intermembrane space AAA protease IAP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_068550</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6Y3"/>
    <dbReference type="HOGENOM" id="CLU_000688_9_0_1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6Y3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="363"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="759"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP50518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="799" mass="87402" checksum="B5D9C206330DB882" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y775</accession>
    <name>B0Y775_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KOW motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_072820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y775"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072820"/>
    <dbReference type="HOGENOM" id="CLU_041333_0_0_1"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="PhylomeDB" id="B0Y775"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000072">
        <property type="entry name" value="KOW motif domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_uL24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="354" mass="40692" checksum="9C5A5A2EBD4484B0" modified="2008-04-08" version="1">MQKIIRRTALARNQAQRKAIRAAKAAEREEFKDALRQRFAFNRIELDNVRAERIRRREDWLRGPLAPKRDAGLDAKTFGSLSPQAMNPPTIPKHLRRKYINIAAGDRVCIMKGRDKGKIGEVIKVDPNNETVMVKDLNMADVHFPEWLNEQYGNKTPFNSVNLPISLDDVRLVVALDDPETGVTRDVLVEHVYGGEPILEREYGTDTPKHTRYIAGENIEIPWPRSEPATMKDEEWDTLRMEVETPTWIPSLHNPPFPPSVLDELRNPFSKYRTRHDPEWVESKKMEDLRKEYLQSRSLMTPKGEFLAMLRAKKAERMSARRDADGNYIMDDQTAGFIANFMQQNAAKKAGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7I0</accession>
    <name>B0Y7I0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_073880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7I0"/>
    <dbReference type="HOGENOM" id="CLU_150783_2_1_1"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7I0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="95" mass="10324" checksum="7235F69E1C881DB6" modified="2008-04-08" version="1">MGDAYEREQQNNALLNSLSSKVSALKSVTIDIYDNARDHETLDHSVFSSLSTNLKGSASRLTRMAKQGDTVAIMKVAGIVIGAGIVLWLLLGWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7N2</accession>
    <name>B0Y7N2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_074400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074400"/>
    <dbReference type="HOGENOM" id="CLU_009629_1_0_1"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7N2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000193">
        <property type="entry name" value="Protoporphyrinogen oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP49413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="603" mass="66859" checksum="8536411991FB2561" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7X5</accession>
    <name>B0Y7X5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_075350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7X5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075350"/>
    <dbReference type="HOGENOM" id="CLU_048008_0_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7X5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="87"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP49506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="328" mass="36318" checksum="6C24009EACF2EE84" modified="2008-04-08" version="1">MSSNKYIRASDSQLPHVPDQFTPGTHSSGSQPHQSKEMLQLQRSRQASGHQSRETDIRSGKVIQGPPKALGLPQVVGSDSSTSHPLIVREKESPWNTFKPVFSCKLAGTVIIAAHKTRPSQLEAIRAYSPEQADEMLRAFQVIRHENILSAKECYREGNRLFVLVDDLPLTLEHLVSLHPDQHQVASVMHQILNGLHYLVEAGFEHTSLTSSNILLGSDGIVKIAALEHCVKRPRTQSQAQVINSLATIMMQLMQSYEMDDGVIGVDDLGRWPPDSEAFGFLEAISLARSVEALMKHPFVAKKHRPGELVALARLAPIATKTFYSCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y825</accession>
    <name>B0Y825_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_075860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y825"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075860"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="PhylomeDB" id="B0Y825"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="344" mass="37409" checksum="C58D868E6E8659DC" modified="2008-04-08" version="1">MMSIVSPLYIVVSVIHTNMIRKRLFSTLRALQHENPLGLPRSGTPPSFPRRRGLPEKRKIRDVKKVIAVSSAKGGVGKSTIAVNLALSLARRGIRTGILDTDIFGPSIPTLLNLSGEPRLDENNCLVPLTNYGLKSMSMGYLLPQPKPDPSQPTGNIPMDTTPISWRGLMVTKAMHQLLHSVSWGPLDVLVLDLPPGTGDVQLTIGQELIVDGAVIVTTPQDIALRDAVRGFGMFEKMNIPVLGMVRNMAYFACPQCGHQTKIFSHGESHGHGSADSDSGVVAECKRLGVKFLGDIPLDAKVCEDADRGVPTVVSEESDDRSVRRKAFLDVAQKVAQKIGLEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8C1</accession>
    <name>B0Y8C1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_076820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8C1"/>
    <dbReference type="ESTHER" id="aspfu-q4wm86">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_14_4_1"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8C1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF11">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="11"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="495" mass="54793" checksum="A1F1B00B99F70C32" modified="2008-04-08" version="1">MATILQTRSLGEVRAKTHDGVSQFLGIQYATLKDRFADAELIEQREGGILDASKDGPTALSPLFGCDFELGHIQHILPKKELPQSDLKCLNLNITVPAGTTAASKLPVFLFIHGGGLVLGANSWPQFDYARFVRLSVEKNFPIVAVSMNYRLGAFGFLTSNELRRAGYNANNGLRDQKVAMRWVQKHIADFGGDPDNVTLAGMSAGGACVTYHLDSDEQLFKRAIVMSGTCLLIQPLPYELHEQNYQQAIAALGLTNASSEERIRALLETPGDDLVAKIPPTVLAVPAIDGTMVTSPVTYAQVADKNSDFPRGKKWCEDLMIGDAQMDILDKYNITREMTDDEAFPAILNYVNDIAFFAPVLTFAKGWKNNVYVYHFNEGNPWDGPWKGRASHILDLAYLFQNFREFMAPDQQQLAITFAEDLFKFCHGVKPWPSVAHDDVEAGFTARVYGPAPNAAQVNGPYYEGSLRRSVLFDHTDQASLDEFAQVLALFRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8Q9</accession>
    <name>B0Y8Q9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_078220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8Q9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078220"/>
    <dbReference type="HOGENOM" id="CLU_170475_0_0_1"/>
    <dbReference type="OrthoDB" id="4343031at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="112" mass="12909" checksum="24C8C338A5775D58" modified="2008-04-08" version="1">MSLRPITTTLRTSVRFRPLPLLRAYHNPELHSNKGEKFYIPAQYPDNFESPSLIKTKDSSGHERWEEVDSTVSEASVKADRGDVQFEVKQKEIKTKQKVQPDLEAEPTVHDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y903</accession>
    <name>B0Y903_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_079170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y903"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079170"/>
    <dbReference type="HOGENOM" id="CLU_036200_0_0_1"/>
    <dbReference type="OrthoDB" id="4323953at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="332" mass="37283" checksum="291632E86C4AA60F" modified="2008-04-08" version="1">MLVRSNFDFTEDLEPAQVNCDQLQAKSLHPRVVSMSDPCFRQLDPGSSISYKVALPSVYFDSFLPGQCYKILWVGGQIFLWDWGTLAEHYGRTLGPNSTAVVLPGGPRHFLSIAPEESDIDDVGPLPPSPQPILASARMSGAPVFSLTIAGPATLSMRDRNPAGRLRYSVTMTLSYDAAPNGLDGMPVTFHTFIFKDIDRRQEGFRLYLRQKDDWSPHEIAGSFTHHEYRFSERVPVNVGHDNQDKFGALVPGESWSFKREVTDFPTNVSPGDKLRYGFKGAQLDWWDWGHFRDHENTVVWINGKVRDPKDNGGRPGLVVPASNWVEFTVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9F6</accession>
    <name>B0Y9F6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K+/H+ antiporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_080860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9F6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080860"/>
    <dbReference type="HOGENOM" id="CLU_005126_10_0_1"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9F6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="45"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="754"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="898" mass="96087" checksum="07045289E320A95F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9H0</accession>
    <name>B0Y9H0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_081010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9H0"/>
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    <dbReference type="HOGENOM" id="CLU_2170499_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="110" mass="11234" checksum="09BF5A931FFE0DBD" modified="2008-04-08" version="1">MKFDSALPVLAVSLAPVAALGQLPYVGGGGGSLPDVGGAADLAKPGQVTGQLNGLLEGLGLNSLDLSQVLTIDWDNDKPPLSTGAPQSPRHRRPGKDQRAGEQGQESQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAH8</accession>
    <name>B0YAH8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Na+/H+ exchanger family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_084720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084720"/>
    <dbReference type="HOGENOM" id="CLU_024407_2_1_1"/>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="PhylomeDB" id="B0YAH8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF2">
        <property type="entry name" value="SODIUM-HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
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            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
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            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="373"/>
        </location>
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        <location>
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            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="570"/>
        </location>
    </feature>
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        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP49021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="602" mass="65507" checksum="5758C7405AA8442A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAN2</accession>
    <name>B0YAN2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_085250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_020129_2_1_1"/>
    <dbReference type="OrthoDB" id="4347796at2759"/>
    <dbReference type="PhylomeDB" id="B0YAN2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="199"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="425" mass="47184" checksum="DE1DF11A1A3A861B" modified="2008-04-08" version="1">MGGGLLTQPMAFPQSNHATAPVPVIEHHSYFQLGDKRFLALPELELDLPTAITSLATVFQLGPTETPNSTWLQNQIQAWLHIDDIFQPEFLSGIIVVTEDNGIQPNLSASIESLPKEWKPDWWIFFNKEVGGQLHPGPRMVSYGKIHTVYRIYDDVNGAFMVAIQPPITPGPFKNLHVSGDFYTSLGVAVSSRIPGVYAEDKPLGGVRFAIKDIFEVEGLRVTAGDRAFYSLSKPAAVTCPAIKRLIDAGAELLGTLKLGSLIAREEPTESVDYHAPFNPRADGYQSAWSSSGGSGAAIASYDWVDFTLGTDKDPEWLTIMPQQQEAVGGPQWQMELSRSALRMTWFPWTMQYPLFQKWVGVWLNQTSAVYDDMQLIDSFIADMEATFGIKTEKVSIADTWKAFPPNEAGNHTIQEYLKDSIQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBK8</accession>
    <name>B0YBK8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_086970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086970"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_2_1"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="PhylomeDB" id="B0YBK8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="452" mass="49477" checksum="82DF18E1E732BD72" modified="2008-04-08" version="1">MQEFHVEDATQSNLPTSVFLIGYIVGPLAFSPLSETVGRRLVLLPTITVFTLSTVACALSPNWGSLLFFRFICGTMGSAPQTVVGGVYADMFFDLRERGRVMAFYMASASFGPILGPIISGFASPSYGWRWTFWIASILAGCAWICLLFVPETFGPVLSRRNAPGLGDTVPKNTVNVVQIVKRPLAMLLFEPIITFTSIYIALAYGLVFFYFQAYPIIFDGLSPVLLATLCMLTSQVSTASMCRLPLLLFYLVGISFPVPCATLIEIVGVGAASTSLVALYWDMTYDKAKKHNKPWRFGAELHRLPISCLGAVLLTASSFWLAWTSRSAVHWAVPIASGVVFGFGYQTIFVSLLTYVTDAYKIYSASALASSVILRSVLGALLPLAAKPMYETLGVSWATSLVGFLSLACVPIPFVLLYKGEWVRERSKFCQQLMKEEWAKGSSDTERGIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBT1</accession>
    <name>B0YBT1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LipA and NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_087720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087720"/>
    <dbReference type="HOGENOM" id="CLU_022880_0_0_1"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="PhylomeDB" id="B0YBT1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="562" mass="62143" checksum="995F28496B3D4D7A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBU4</accession>
    <name>B0YBU4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_087850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087850"/>
    <dbReference type="HOGENOM" id="CLU_012348_11_2_1"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="PhylomeDB" id="B0YBU4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000039">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="115"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="614" mass="69329" checksum="34E8091A625E0262" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCT9</accession>
    <name>B0YCT9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_093170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093170"/>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="PhylomeDB" id="B0YCT9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP47473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="355" mass="38216" checksum="1E5D91208D1D506D" modified="2008-04-08" version="1">MADFLALPSFLVENSAAVALKDAYNSFSERRAALGLSNPGTVDNIAREVQKEVLLSNFMFSGLRADLTKVFGMSPLFRVSHAFSMGGSGNLPPYAFSAMYGTPKVFMQGNFGSDGALAAVFNYRWNPKLVTKTNTQIMAGASQGLLQIDNDYTGDDFSASIKAFNPSCLDGGLTGIFVGSYLQSITPSLALGFEAIWQRQAMNTRPETALSYCARYKANDWIASAQLQAQGVFTASYWRKLSERVEAGVDMNLQFAPNAAAALMGGPSRDGTTSIGAKYDFRASTFRAQVDSAGKVSCLLEKRIAMPISLTFAGEIDQAKQSAKLGLAVSLEIAGEELMEQQEKIEAQGMIPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD35</accession>
    <name>B0YD35_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_094130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094130"/>
    <dbReference type="HOGENOM" id="CLU_050414_0_0_1"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="PhylomeDB" id="B0YD35"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="347" mass="38652" checksum="0AF09C35860CD988" modified="2008-04-08" version="1">MAPPNISHRQTHNLLLISKLLSLRDTASPLTLLLDSLEQPATPLIHEYIRRAKLSKVHVTLVAFETLRPFEGVDAFISARKKRPSEIVKEVGAAYQPVANVPSRRRLILIDSINPLLRSKKTDSQFHLPTFLGSFIAPPGSSPTKAETSLIVTFHQDVPNQLCATPYSPSSFSVLSYLATTVIKLHSFSHILAQKAARDRSLAAPVFGLEEELDGVLLGRLDKPTGKDSAEGVVLEMEHRRKSGRGVLEWYVLPPAARYPSNYAKEIVILLDDHPLYRPPVEPDVGMGSSEPESTFELRLTERQRREREGVVLPYFDAQQGDGPGEGGRILYDMGEEDDFDEEEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDC9</accession>
    <name>B0YDC9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_095120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095120"/>
    <dbReference type="HOGENOM" id="CLU_045148_4_1_1"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="PhylomeDB" id="B0YDC9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="83"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="399" mass="45240" checksum="BC8BBD001185CE15" modified="2008-04-08" version="1">MIDEIEHTAWNDRTGWIMASISISYITVAKAKQIRERRPSITALRWNNFLSCRSCFNNTVLHSWRNHDPMAIIRSTKNDLSVAEDFSIACFIAVSWYNAIELIVLCFTTFKKRGGFYFWALLISSIGILPFGLGYILLIFDIYPGYFSVALADVGWCAMVTGQSLVLWSRLHLVVYSRLVLRATLAMIIIDGVILHTIGWVFEMGEQSPRSDWFTPAFSIFERIQLIGFSIQEIILSIIYTKASLQLLKLRPRQQYRSTLVQLVIVNILFILMDAAIVTFQYAGLFHVHVSFKAMVYSVKLKLEYAILGKLVHMSKMSHSNSAPTDRSDAVEMSSRRTNNRSHLEQTRQHRESQTSIIREGAAFDGEDLADCSRVGSLKGSFPSSKEPDAASVEVGNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDM1</accession>
    <name>B0YDM1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1690 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_096070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDM1"/>
    <dbReference type="HOGENOM" id="CLU_093897_0_0_1"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="PhylomeDB" id="B0YDM1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28843" checksum="A0DA44C09CC48097" modified="2008-04-08" version="1">MHYNTSLTPIAALSDFIVPGITTTLSLSQYSKGPLPSGQSPRNKSKLQQKALRPNQPSKYKSNPLTSQSNSNAPIQFSSNLVDALQTNTETDSSRAKSLELQIQARVAQELERLREREQQTLAEIEKRLAEAKDSAPAAPSSTPNITYPAGSLNLDAPRIPFAGREYESTPAPTVAADQPINRDLSRESVNAEIEQLRAKLEGRRKLVEVDENVERARNEVVTCLRLHDRRPLDCWQEVEGFKREVARLEEAFVDRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDQ4</accession>
    <name>B0YDQ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_096400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDQ4"/>
    <dbReference type="HOGENOM" id="CLU_054590_0_0_1"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="PhylomeDB" id="B0YDQ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760632" evidence="1">
        <location>
            <begin position="28"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="317" mass="34921" checksum="0DB9B45285B4F66C" modified="2008-04-08" version="1" fragment="single">GNTKQPRSSSSLLTILLPLYLIIGHGAQLLSSIANRSKRYLCASLLGSVKPRSIYAFRPLHCSSVNMSGISKACCSIPPIVAQGYQGKGEYKTINGMKTYVTGPDSASKAIFIVYDIFGFFPQTIQGADILATSSEQKYRVFMPDFFEGQPADITWFPPQTEEHKQKLGNFFQTKAAPPANLPKIPSFVDEANKLAPNGKAFESWSILGYCWGGKIACLSSAKDTKFKAAVQCHPAMVDPNDAKNVTIPMAMLASKDENPKDVEAFGANLKVDHYVETFSTQIHGWMAARSNLEDEEVRKEYERGYKTALSFLQKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDV1</accession>
    <name>B0YDV1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_096880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096880"/>
    <dbReference type="HOGENOM" id="CLU_1602310_0_0_1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="PhylomeDB" id="B0YDV1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="166" mass="18560" checksum="B1041BBD8EAB68AC" modified="2008-04-08" version="1">MFDDPTAYPISIYQGWAQKYLKGLPDYKRAIYRSFNPVCSFAYAVSREGARKVLELVGGAKDEAFDVAVMRNCKLEKLNCISIVPEVIHQYFPALSFGVKSLVDIGNGEKPGPGDEKFENVMGSTENILESARCSALWGKKCPRLVCVFSSKDYIHLARFPACSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDY6</accession>
    <name>B0YDY6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_097240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097240"/>
    <dbReference type="HOGENOM" id="CLU_059949_0_0_1"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="PhylomeDB" id="B0YDY6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF6">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="311" mass="33997" checksum="48A3B622FBBCB9F8" modified="2008-04-08" version="1">MAGCAKILVIGAGELGNQVLHALAQHPNRGGATIAVLLRPSSIASTHPDKVKELEELRNLNVQLIPGDIAKDSEEQLSDIFGEYGTIIGCTGFAAGSGTQLKLTRAVLAAQVPRYVPWQFGVDYDIIGRGSAQDLFDEQLDVRDLLRSQNRTKWAIISTGMFTSFLFEPWFGVVNFKGDTVTALGSLDTKVTVTAPEDIGRITAEAVLGSRADSVFGDKPIYVAGDTLTYEQLGQLVERITGRKFTRHVRTVEAARADLARDPGNTLFKYQIVFGEGRGVAWDLSETWNCQVGIRALTAEEWARRNLQNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE34</accession>
    <name>B0YE34_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_097690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097690"/>
    <dbReference type="HOGENOM" id="CLU_1602311_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="166" mass="18666" checksum="C89254EF649086A2" modified="2008-04-08" version="1">MALPTKVVPMDLSEEYANGSNIQSLQKSPMDRGSTPLDRTDRFNPTMTTVNASPRGTSIADVITKPDTHQSHRQKRGDICLSSSTGLLRMSSTYETLSTSYTVLIYRFRAMNGQQNERIIRWSEDGNTVVRVNEQELTTKLLPAFNITNYFSLTQQLEKLGFRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YES7</accession>
    <name>B0YES7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_100230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YES7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100230"/>
    <dbReference type="HOGENOM" id="CLU_088654_0_0_1"/>
    <dbReference type="OrthoDB" id="5371016at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="234" mass="25906" checksum="E64282F2F6DC34BC" modified="2008-04-08" version="1">MQQVYTHEGPYESIPSTASPGLQFLRHFLPALDSLDPTTNPISPFIHPDARVVVGSGPPNRGTDVIGLLNVRQRHIQRFQHEIHKAWDIARPDTGNGNGGPRTVMFEATSGTVFRNDPDEFEVQVREFNILELQRAGSQSNGDGEGKGGFVAVEMRTFMDARPVQDQAARLQRESAYGEAKSTGWDHSTLNCRTSLQWVQPGWQHRIELCEVQSLTLISQLGFLSGPAVAANVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEW3</accession>
    <name>B0YEW3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_100710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100710"/>
    <dbReference type="HOGENOM" id="CLU_086437_0_0_1"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="168" mass="18511" checksum="D8B8A376821C8E26" modified="2008-04-08" version="1">MGNVNSITQCFPLQRTYTQTSPSRETREVASNVVTIILTSDTPYAIKKRLDESIRTAGWTESLALAILRGLENAIETGAQVAEAASKALARATSEAFEFSREHPIFVTILALGVLAILTPWVIEVLGFGELGPIEGSFAASWQRTYAGYVPKRSLFSFFQRVGMVWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF41</accession>
    <name>B0YF41_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS quinate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_101490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101490"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="B0YF41"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="557" mass="61440" checksum="82548058C92D47C0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF49</accession>
    <name>B0YF49_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_101560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101560"/>
    <dbReference type="HOGENOM" id="CLU_045148_4_1_1"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="PhylomeDB" id="B0YF49"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="268" mass="29871" checksum="3F2E55187115BEEF" modified="2008-04-08" version="1">MPTFTTTSSNPGLDHRLSSPILEHYVYPTFIAVAWCNAIDLIVLCFNTFKRYSGPYFWSLLVSSFCIIPFGLGYVLKIYSITFTNYFLEIAILDAGWSGMVTGQSLVLWSRLNLVLDNRRVLKALLYLIIVDGAVLHTACTALEFATNALPSNGVAIAFDVMERVQLVGFCLQELLLSGLYIYKAVPLLKMDADRRSRGVLVQLIVINAVIMALDVSVVIVQYLGLFTLQVTSKALVYSIKLKLEYVILGRLVDVSRVRSPAAARMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YFB4</accession>
    <name>B0YFB4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">EF-hand superfamily Ca2+-modulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_102960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499638">
        <property type="protein sequence ID" value="EDP47057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YFB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_102960"/>
    <dbReference type="HOGENOM" id="CLU_112519_0_0_1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B0YFB4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="213" mass="23472" checksum="667C9D7440DF8AFA" modified="2008-04-08" version="1">MITEEVVKAAAGNWRSGERVLALLLEKRGNDVMVTDKVVKAAAGNWRSGERVLALLLEKQGGNFEVTENLVSLIAGKFGARIMALLLKKRGDEVMITEEVVRAAAGNEWSGEKVLALLVEERGDEVMITEEVLKAAAGNEGSGEKVLALLEKSQDGMGMQAKDELIWIRKLQNMFHDALITTVLMNKSHQRTLKSGCQRRDRQLTTTGMLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM23</accession>
    <name>B0XM23_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_001740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001740"/>
    <dbReference type="HOGENOM" id="CLU_061221_2_0_1"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="PhylomeDB" id="B0XM23"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="185" mass="19931" checksum="4D908AFF03DB3EE6" modified="2008-04-08" version="1">MINAVLVFNNNGQPRLTKFYTQIDTQTKQSLIAQIYDLVAQRPPSACNFLPLPPLLSQGARSSAANGPSDAPTQVTYRTYATLSFIMISTSTESPLALIDLIQVFVEALDRIFENVCELDLIFGFETMHAVLSEMIVGGVVVETNIDKIVAGVREQEGNLGKKKAIQAASSGLGRGGLSGLGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM76</accession>
    <name>B0XM76_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_001200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM76"/>
    <dbReference type="ESTHER" id="aspfu-CBPYA">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001200"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="PhylomeDB" id="B0XM76"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="14">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP55428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="543" mass="60930" checksum="56E9C68A824C8CD9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XME7</accession>
    <name>B0XME7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_001460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XME7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001460"/>
    <dbReference type="HOGENOM" id="CLU_073146_0_0_1"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="PhylomeDB" id="B0XME7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="242" mass="26225" checksum="98F86984410E8369" modified="2008-04-08" version="1">MGIPMNDNIHAPTVPSGPTSGGVTRDLSKLTMVDLMQEKERIEAELSALSAVLTSHGVNMNTSLTTFDGFPRDDIDVAQIRTTRARIIHLRTDHKEVMKHLEKGLHEHFASLQRAQAAVAASGMNGTSVQRSNLGENSLSNAEMIGTPFAKVNSVVPDSPADQAGLKAGDIIRSFGNVNWINHERLSKVAQTVQQNEGRTIVVKIVREDGPASNNTTELSLELIPRRDWGGRGLLGCHLVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMX3</accession>
    <name>B0XMX3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_003629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003629"/>
    <dbReference type="HOGENOM" id="CLU_1594148_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="167" mass="18558" checksum="7F29DBBB4E383396" modified="2008-04-08" version="1">MPCREDDGVWPSHPTRLVSSRLSLNQPALQGDRPTCLFALASAVATRTQIAWYTFGQPLGAPREVTVKNGTPKPTACASSQQPLRVYKTRATSNLSSFCTRDKTEEKKPIYHPHRPSPALQQSPLAYSSSDPTPSRLELWLSRTGLGVYLWSEVSYPSLSDQKKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNI6</accession>
    <name>B0XNI6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_015280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
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                <person name="Silva J.C."/>
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                <person name="Bussey H."/>
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                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
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        <source>
            <dbReference type="EMBL" id="EDP55849.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006030"/>
    <dbReference type="HOGENOM" id="CLU_115908_0_0_1"/>
    <dbReference type="OrthoDB" id="4161285at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="187" mass="21057" checksum="D566B14739002E53" modified="2008-04-08" version="1">MDQPPLSPPAEPESISTANLPSNAPVPLDSPLRTNPIHPSLPDIRVPGSPLRPYQYDPVTCTPIDLESDSFRTQLDHLRTEYATPSAALKAQEQVAKEAKRKIEEAEKKREEVQKAMDKKVKERDTEMKVLSKYQKSGTALRTLQKPGGSHNYVRCNRLRRRQNRQTGVYGQHNTAARSLKYGLMGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPA1</accession>
    <name>PGLR_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable endopolygalacturonase AFUB_016610</fullName>
            <ecNumber>3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pectinase AFUB_016610</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Polygalacturonase AFUB_016610</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_016610</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPA1"/>
    <dbReference type="SMR" id="B0XPA1"/>
    <dbReference type="EnsemblFungi" id="EDP56939">
        <property type="protein sequence ID" value="EDP56939"/>
        <property type="gene ID" value="AFUB_016610"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016610"/>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="PhylomeDB" id="B0XPA1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000393690" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393691" description="Probable endopolygalacturonase AFUB_016610">
        <location>
            <begin position="36"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 2">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 3">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="345"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="378" mass="38425" checksum="BD35BEE28B707357" modified="2008-04-08" version="1" precursor="true">MLKLMGSLVLLASAAEVIASPAAEPVAPSTTLEKRAPCTFSGSNGAAAAMASQKACSTIVLSNVAVPAGTTLDLSDLADGTTVTFEGETTWGYQEWSGPLLKISGKNIKVKGASGATLNPDGARWWDGQGGNGGKTKPKFFAAHDLTSSSSITDLHILNTPVQAVSINGCDGLTITDITIDNSAGDTQGGHNTDAFDIGSSSNIIISGAKVYNQDDCVAVNSGTDITFTGGLCSGGHGLSIGSVGGRSDNTVENVSFTNSQVTNSDNGLRIKATKGKTGTIKGVTYSGITLSSIRKYGILIEQNYDGGDLKGDPTSGIPITDLTMQNISGKGAVASSGYNIAIVCGSGACSNWTWKSVEVTGGKTYGSCKNVPSVAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPD6</accession>
    <name>B0XPD6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_016970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016970"/>
    <dbReference type="HOGENOM" id="CLU_029943_0_0_1"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="PhylomeDB" id="B0XPD6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000060">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000052">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF24">
        <property type="entry name" value="PHOSPHOESTERASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G17590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758219" evidence="2">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="456" mass="49896" checksum="E9296F2ABD0190FB" modified="2008-04-08" version="1">MHPSALLGLLAFTVAASAIPAPPASAHSKHSINNFKSKIKNVVILVMENRSFDNLLGGQKLKGLENPVNTGPYCNPYNLTDPSQGVACSAAKDFDSITNDPDHAIYGNNIEFYGTFNPDNTQIAEGKLVPHNQGFVHEQVRKYGAKVNKTVLATQVMNYYTEEQVPVLTSLVQNYLTFNHWHSDIPGNTNPNRAALVSGTSLGHGLNDAAFTKHEFPQRSIFQQLTETGHSWINYVDPAGGTGPDAGYFNWTYATNNQDKIQPLAKFYTDAAAGALPELAYLNPSCCGVGTTSMHPAGLISDGEAFIKKVYDALRAGPQWEETLFILTFDESGGFHDHVPAPLAPRPDNLTFTLSTPSGEDYTFPFDRLGGRIPTLLISPWVAKAQVEQKGKNAHGETVSYSAASILRTLGYLWDFEPFTPRVEHAASFEHLIRLHARKDTPTALPSAVPFRNRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPV1</accession>
    <name>B0XPV1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome segregation protein (SepB), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_007670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007670"/>
    <dbReference type="HOGENOM" id="CLU_004219_2_1_1"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="PhylomeDB" id="B0XPV1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000790">
        <property type="entry name" value="Chromosome segregation protein (SepB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001107">
        <property type="entry name" value="Chromosome segregation protein (SepB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="11"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="417"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="727"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="841" mass="93788" checksum="46F468A548A25EA1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ91</accession>
    <name>B0XQ91_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_009140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ91"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009140"/>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ91"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001690">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="6">
        <location>
            <begin position="66"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="5">
        <location>
            <begin position="386"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="4">
        <location>
            <begin position="550"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="834" mass="94214" checksum="1B998ED50C0E7AF5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQF5</accession>
    <name>B0XQF5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_009770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009770"/>
    <dbReference type="HOGENOM" id="CLU_141774_0_3_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="83" mass="9700" checksum="7A0D7C4D375E3861" modified="2008-04-08" version="1">MSNTTQTKDKPETSEQSTQQKPTVLEEDDEFEDFPVEDWPQEETEQANGNNVHLWEESWDDDDAAEDFSKQLKEELKKVEASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQH9</accession>
    <name>B0XQH9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear localization protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_010020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010020"/>
    <dbReference type="HOGENOM" id="CLU_013061_1_0_1"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="PhylomeDB" id="B0XQH9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="728" mass="77661" checksum="0B44482F29FE7FE2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQL8</accession>
    <name>B0XQL8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_010410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010410"/>
    <dbReference type="HOGENOM" id="CLU_022876_0_1_1"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="PhylomeDB" id="B0XQL8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="325" mass="37655" checksum="62B3250A49337E2A" modified="2008-04-08" version="1">MSNLQKTPFVKELASSDRRTRDKATESLTLFLRSKTDLTLLDLLKLWKGLFFCFYHSDRPLTQQALARNLSYTLVPTLPRQTLHRFLRAFWITIGRDFHSLDRLRLDKYLYLIRCYVGVAFEIFLKGNKGEQQQSTHTNGASKKRKREEQTAAGKKKRSKADKEDEARDEADVEEGQDGEGDWAELESYMTIIEEGPLCPLNFDPDQPPADEKNPNYVPMPHGPDGLRYHLLDIWIDEIEKVLEFEEGETQDGSSRKVKGQVPMELLLRPIEKLRKESPFKPVRTRAAETLNDDRLVQWGFKTREVEEEDGDDDSEQEWGGFADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQQ2</accession>
    <name>B0XQQ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactonohydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_010760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010760"/>
    <dbReference type="HOGENOM" id="CLU_036110_1_1_1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="PhylomeDB" id="B0XQQ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757775" evidence="1">
        <location>
            <begin position="17"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="213"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="442" mass="49115" checksum="BCD3E61E82D5E6A0" modified="2008-04-08" version="1">MKHLVAFTLNAALVLGVVVLQRRDESTQQHPLLDSFRHSPGIATDDALVHQCIAPGVVCVDKHGANLPYPFWRDSPNGTYASNLADIEFTGGRGQPKSTSWEQVERADFVVFDEERGRKLLGENPRVDFVFSVNPWALHEAPTYVPGLHQIFFSELSPMLEQFVIELKVDPPTLSTFRADPPIYVPNGGFYHDGLIYYSVAGSSHQHKQRPGLVTLDPWTKKSSTLLNNYYGLTFTDCDDVIVDPVTGFVWFTVPYYSWWLEVADTPPQLKSATYRFDPATGSTVVVNDEMRSPNGIALSPDRRHLYISDTEAAGQSAPISLDLPSPGVAGLLFNTTGKRTIYKFDLIDQGHAIANKRPIHYDAIGTVPDGLKVARNGWVVTASGNGLSVMDEYGEMIARVQVNFTVNNFVWADVDDYREVWMVGQGGVGRVRWELQGQKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR23</accession>
    <name>B0XR23_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_011980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011980"/>
    <dbReference type="HOGENOM" id="CLU_044876_2_0_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="B0XR23"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF11">
        <property type="entry name" value="ISOFLAVONE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G12510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="314" mass="35184" checksum="9D8A3165E68A5854" modified="2008-04-08" version="1">MPSQLRKILVLGATGVIGRYIVKAIATAAPTSFDRVAIFTSENTINTKKEQIQWLRDHGVEIIVGDLNDEARVREAYQGFDTIVSCLGRNMIAAQINLIRIAETCPNVIRFFPSEYGTDIEYGPQSAHEKPHQFKLQVRKFIREEVKRLEHTYLVTGPYADLYLENASKCPRAGTFDVANKKAVLLGDGNGRISLTTMSDVGKVLVAAIINNEASCNQALKVNSFTTTPNEILAEFERQTQAKWEREYTSLPELKQLEQELWEANDPLAVVATLRRIWTEGGTLYEMRDNDKIHAPDMDTLEIAVARAIEAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR65</accession>
    <name>B0XR65_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_012270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012270"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="PhylomeDB" id="B0XR65"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="56"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP56516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="385" mass="41727" checksum="DF8B9F70C25627DE" modified="2008-04-08" version="1">MISARNFVAPARQCLRTTRVSSGFASHLSQLRGYASAADDRVAKFKGQKGPDGKYTVTLIEGDGIGPEIAQSVKDIFAAAKAPIKWEPVDVTPILKDGKTTIPEEAIKSVQKNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANLRPCRSVAGYKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYARSVNKKKVRVVHKATIMKMSDGLFLNTAREIAKEFPDIEFDAELLDNSCLKIVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLHEHAARIQKATFDTLAEGKTLTGDLGGKAKTHEYAEAICKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRE9</accession>
    <name>B0XRE9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamin pyrophosphokinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_002230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002230"/>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="PhylomeDB" id="B0XRE9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF11">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="327" mass="36751" checksum="956D2951AE568796" modified="2008-04-08" version="1">MKKTILEIVKDCDNFPYNQPGETAAYEQQISKLWKFFLPNDRRPHGYLVESVVERMPWTEDFHVLPAPHKEIHLLPQDHAREQETWTERCERSLDALIALARARGVFPRLGKPRDERFPIIGAQFPVSIERSAISLFGIVGRGVHMTVYTRTKSGLKIWVPQRNLKKSTYPGMLDNAVAGGVAAGERPMDCLIREAEEEAGMEESMVRKAHAVGTVTWFNISDDRAGGEPGLMNPGLLYVYDLEVGPEVVLNPVDEEDVCAFHLMDVREVLDAMAEGKFKPASASVMVDFLVRHGLITAEDDDDYPEIVSRLHRLLPFATSPTAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRQ4</accession>
    <name>B0XRQ4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_013500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRQ4"/>
    <dbReference type="SMR" id="B0XRQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013500"/>
    <dbReference type="HOGENOM" id="CLU_061221_3_2_1"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="PhylomeDB" id="B0XRQ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP56638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="145" mass="17090" checksum="4D23E7D3A1B4EBB8" modified="2008-04-08" version="1">MVLSFILVQNRQGKTRLAKWYAPYSDEEKVKLKGEVHRLVAPRDQKYQSNFVEFKRSTKIVYRRYAGLFFCVCVDATDNELAYLEAIHFFVEVLDQFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRU3</accession>
    <name>B0XRU3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_024850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024850"/>
    <dbReference type="HOGENOM" id="CLU_066901_0_0_1"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="PhylomeDB" id="B0XRU3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="40"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="229" mass="25203" checksum="21832B7997CB6F57" modified="2008-04-08" version="1">MAAISRACRIRYCSQATQPYCTPPISPTDQRNPSNSTHSICDIQEKFHAIYEFPKLITTTTKLLKASSALNIPIYVTTQNRPRLGDIVSELQPYLSTPLVRANIDKTLFSMITPELDALLPNVKGGETPLDVIIVGIETHICITQTTLDLLERGHRVYVIVDGVSSMNKEERGVALARLRDAGAVVTSSEGILFEILGDAGRAEFKAVSGLVREAKEETREAMEVFSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS06</accession>
    <name>B0XS06_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_025490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025490"/>
    <dbReference type="HOGENOM" id="CLU_027363_1_0_1"/>
    <dbReference type="OrthoDB" id="4840035at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="103"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="623" mass="69889" checksum="4D14E885F7D2E2B1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSX5</accession>
    <name>B0XSX5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_028130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028130"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="PhylomeDB" id="B0XSX5"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="487" mass="52624" checksum="FF6F9B06C5364003" modified="2008-04-08" version="1">MAFMRVASRQLPLTKRLVPGFQSSVQRRFASPAAGTQTSNTPQDVKAQVTKEAVLPNPDPAAESATAAFIRERTPYMVPTYVRPTPVMIKGQGCYVWDMENRRYLDLTAGIAVNSLGHCDPEIAKIIAEQAETLIHASNLYHNAWTGALSKLLVALTHQSGAMRDASQVFISNSGTEANEAAIKFARKVGRSLEPSGAKHEFVSFHNSFHGRTMGALSATPNPKYQTPFSPMVPGFKYGNYNDIEQLQELITDKSCGVIVEPIQGEGGVHTATPEFLAALRKRCDEVGAVLIFDEIQCGLSRTGSFWAHAHPSLKPTSGEAAHPDILTTAKALGNGIPIGATIVSGKTVAEHIKTGDHGTTFGGNPLACRVAHHIVERLASPELQKSVEAKSLLFVSGFQSLQKKYPDVISEIRGRGLILGVQLSKSHTTKASDLVTAARERGLLIITAGEGCLRFVPPLTITEEQIKTSLKILEQAFDAVFSQTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT61</accession>
    <name>B0XT61_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activator (Sac7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_018140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT61"/>
    <dbReference type="HOGENOM" id="CLU_004568_2_0_1"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="PhylomeDB" id="B0XT61"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
        <property type="entry name" value="RhoGAP_fSAC7_BAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="99"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="874" mass="95219" checksum="C835B267671B7F3C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTA6</accession>
    <name>B0XTA6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_028750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028750"/>
    <dbReference type="HOGENOM" id="CLU_061830_1_0_1"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="PhylomeDB" id="B0XTA6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="260" mass="29693" checksum="8A655457283745B5" modified="2008-04-08" version="1">MAPIAIPQFLLPRGIPSSRTLHALTRRRNPTTLATTVPSLCRCASSDDGSKPRVLAKPDKFRPPSHPARRVVPTRNGRVVSGPINYPGPRLSEKEKEEQKTRKYPNMFPPEGTIMYKFLTSRWIHIWIAMGVLTSLATFTFTTNFKHSSPYAHLLPPWSALLTHPIDTIGQALAVFRMHVQHTSMETREKRLKRVEDAEKRRQYRIAHGLEEPNEKTERQNPEVVDDQSPVAVDIPAVGPDEYVDWEGKKRPVKKWLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTF6</accession>
    <name>B0XTF6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_029240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTF6"/>
    <dbReference type="HOGENOM" id="CLU_023861_4_1_1"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="PhylomeDB" id="B0XTF6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="258"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="447" mass="48586" checksum="3A358D8A59CCF5D3" modified="2008-04-08" version="1">MARCYSTSPSPDQHESALHLPFAHGANDEVARLAGSRRCPLTLADLLKHGRPPLSKEALLASANFTLSLLPARLASRIQALRNLPFIVVSNPHISKIYNNYVHSLSTLLPYQQRKVTTLEEENKFADVLADLVHTHSNTIPILARGFLECRKYISAADVTRFLDTHLRARIGTRLIAEQHLALHFASQPVSDVGSTTEKSSENTVPSNYIGVIDTALQPARIVKVCEDFVGEICELKYGVRPRLKIGGQADATFAHVPVHVEYIITELLKNAFRAVIESGNEREPIEVTIAAAPDVPTHQVHNVLGIKSNAPGIYPDADVGFKMDTVVGTADANESIKFSTPSSQSITIRIRDKGGGIPREVLPNIWSYSFTTFSDSNLLEPDNGNLDALNTISASGGQLSSIAGLGYGLPLSRAYAEYFGGSIAIQSLWGWGTDVYLTLQGVGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTG3</accession>
    <name>B0XTG3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase/oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_018480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTG3"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="PhylomeDB" id="B0XTG3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="265" mass="27352" checksum="EE7EE2763AF07495" modified="2008-04-08" version="1">MLQPSSESSLAGKTCLVTGGAGGLGKAIASTFLAAGANVVVCDVNEDRLQQTSSELGETDRLKTVRADITSASAVQTLFDEIIADFGKLDILVNNAGIMDRFDPVGDLDEALWDKVIGVNLTAPFLLSKLAVRNMLAQPTPDGCIINIVSVAGKAGWAAGAAYTASKHGLVGLTKNTAAFYGNKGIRCNGLLLGGMDTNITDAFQAGFNKEGQEKALDIATAVKARLCEIADVADMCLFLACGKGSKLINGALIPADNGWTGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUK8</accession>
    <name>B0XUK8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_031240</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001975_1_0_1"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="PhylomeDB" id="B0XUK8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:sulfate assimilation"/>
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    </dbReference>
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        <property type="term" value="P:sulfur amino acid biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sulfite reductase beta subunit"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
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        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
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        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="787"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP55063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1530" mass="168611" checksum="A0DF8435790B67DA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV87</accession>
    <name>B0XV87_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_032250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032250"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_3_1"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="PhylomeDB" id="B0XV87"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF31">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="364" mass="39823" checksum="9477240ECED85F94" modified="2008-04-08" version="1">MLPWVHTTSWILHHYASSSLDQASFIMAPYIHTGPIDCERDFDPSSVKGKTAIVTGGNQVQMLSQYHNLALAYRHTGASGLGEAYVRALVAAGSTPGGRAANVGSPSALWLERSPSLTRNLFASSRTKFVPCDAGHWDDQVRLFENAVSLSPNGRIAYVVANAGIHRPDEVFEQPHPDQEPAKPDLTIVDINIKGPLYTAKLAAHYFIRQNGSTPTLGQEDTCLILIGSGAAFLDCPRAPQYSASKWAMRGIMHSLRRTTYYYGSRVNVISPWYVRTKILPEKTFDHVSKVGVQFASAEDAGQCLLRILSDPSVNGHSFFVTARKWASRGYVDLDLEDYPGNALLGEAQEEQMLSAPVSAGLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVG1</accession>
    <name>B0XVG1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="8">SDH assembly factor 3</shortName>
            <shortName evidence="8">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_022120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022120"/>
    <dbReference type="HOGENOM" id="CLU_102310_1_0_1"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="PhylomeDB" id="B0XVG1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="166" mass="19210" checksum="576BE38CD5D239F4" modified="2008-04-08" version="1">MENVQPLWNADPMIRHLLAAFRDTFSNRGSIHHLHRHHPVLNLLLMATPSTMGSKSSLSEALALLPPLQLYRRILRVHRRKLDPEMRILGDSYVKSEFRAHRNVENPLHIIGFLTEWQLYAQKLEGDAWVGEKLDKSKLDKMSDQQIGQLYELMQAIKNPEGEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW03</accession>
    <name>B0XW03_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_033620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033620"/>
    <dbReference type="HOGENOM" id="CLU_058483_0_0_1"/>
    <dbReference type="OrthoDB" id="4350666at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="388" mass="44706" checksum="DF32E465D708C171" modified="2008-04-08" version="1">MPLPVFAVSFAYLYLTGSLVFDTIHWLLHKWSKSQWKILRWLSYCHQFHHLYYNRSLKFNERYARHNSWIALPLEMLCKVFGSMAGWLLARHLMADDKQNISTAALLVACAFEIIRTLVVIAISGRDSNHIAFDTVPKDHNWLFVGPEYHALHHVYPERYMGSMVKVFDWVAGTAYSLRNKRVVLTGGSGAFGCAIEKQLLSEGVKDIKKLHFGKDWTHNDVSGVGKSLEESDILILAHGTKGRDAMDANCKSTMRLIELFLRRKAAEDIQQTKTVPEIWYVGSEIEIHPAWGNPELQRYSASKRAFLPYARALYDHPRIIYRHIVPAAFESRMGKAIVSPDWAARVALWWIRRGAHYVPVTYTGLAFLNFFKFLLLVRPSTRPDWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW53</accession>
    <name>B0XW53_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_023610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW53"/>
    <dbReference type="MEROPS" id="M76.002"/>
    <dbReference type="HOGENOM" id="CLU_079125_0_0_1"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="PhylomeDB" id="B0XW53"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="223" mass="26130" checksum="BF254BD2D31D9965" modified="2008-04-08" version="1">MSDSQPCSTPSTRGKSDSGYIPGDDTWTQWRNIFAILTGQMTDEGKEQFRIARDIRNEAADCKRCEDQRDYLLQYRGDLSSHNIYCRRCTSRKAGGFDPEYGILLCANEMKDQGHLEDTMAHEMVHAYDHLRFKVDWTDNLRHAACTEIRASSLSGECRWAREFFRRGQWKFTQQHQECVRRRAILSVRARPGCKDEAHAEKVVNEVWDSCFRDTRPFDEIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW80</accession>
    <name>B0XW80_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_023880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW80"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023880"/>
    <dbReference type="HOGENOM" id="CLU_2621570_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="78" mass="8873" checksum="403DF7E6FE564259" modified="2008-04-08" version="1">MLPSMGAQFEFPGYTPLNDAVHSHTRDFLTRKHSDWLGLSQLALLGFSMVLRELRLGIIIITLNIAAYRRICIESSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWE8</accession>
    <name>B0XWE8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_035650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035650"/>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="PhylomeDB" id="B0XWE8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760523" description="2-dehydropantoate 2-reductase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="276"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP52401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="414" mass="45961" checksum="355B774D26969771" modified="2008-04-08" version="1">MIEASCLFSPLLLLISSAISNNLMMKCLDPRVTLLSKNLFRANSYAMHSTTPVERNPSSTLRDRVHILGLGSIGTFVAHSVSEIPNGPSVILLLHRRSLLDHYRQNRNQIFFESRHGVHQSSTGYGLEMTQDNQWYPVSDESPSDCPITSHISNLIICVKATQTVSALRPLVHRLNSTSNILFLQNGSGMIEEVDAHLFQDPLTRPNYLIGVISHGVTLNSPFNITHTGFSATSIGPVPRDDGRYAAISDLRSNYLLQTLPLSPTLNLKSYPYTEILQVQLEKLAVNAFCNPLCALNDAKNEFLFSVPDTRRAILTEISNVVLALPELKGVQGLEERFSVARLEKTVNDIIAKTANTTCSMVWDLRAGRETAIQFINGSWSRMGKMVGVDTPVNDALVEQIKMRGRENLEMSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX71</accession>
    <name>B0XX71_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_037040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037040"/>
    <dbReference type="HOGENOM" id="CLU_046290_2_0_1"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36173" checksum="9FCDCC93E76080F2" modified="2008-04-08" version="1">MEASRSSPEGRIPPPRAARTVAVEPVNTASSANAIKEATGKSERSDNVMVALSLTPDPPVPPPSRSTFPRAHYRSRSLAEVSGVLPMTRAHSSPGLDSKGRYIFVNGREAPLTQNDNTPRRFLPLQIPSRDSLEARMAPLNISETISEHAELGTTMKSPPHGEPFTTSPVASHNLRVGRRRPSSPLHFPSATSITQPTSSPSSIHSSPVVLGSKFNEAFPGYSTSSTSSVPSTPTSLRSRSPSISSLETIPDIPDAEDAAIEADRIAALKAAADRADEAEAAANGTRRRGTSDALSPAGSSGSLRGGLGVYGARIDKRKRWSVCGAERRQDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYJ7</accession>
    <name>B0XYJ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_041160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041160"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="PhylomeDB" id="B0XYJ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="98"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="383" mass="43117" checksum="6FF38907EEFA0D04" modified="2008-04-08" version="1">MAPSLVENVALRTAPVTKLKTDAGFNKENVLGYGEAYSHENEVKGTEKQPPASFPHYLPVWDNETERYPPLTPFEHYDHGKDADPSFPDLLPPGKVQVDNLTPTIGSEVRGVQLSQLTKEGKDQLALYVAQRKVVAFRDQDFAHLPIEKALEFGGYFGRHHIHQTSGAPRGYPEIHLVHRGADDRSGAEFLATRTNTVTWHSDVTFEKQPPGTTFLYLLDGPTSGGDTLFADMVQAYKRLSPEFRKRLHGLKAVHSGIEQINASLNRGGIARREGITSEHPIVRTHPVTGEKALFVNPQFTRYIVGYKKEESDMLLKFLYDHIALSQDLQTRVRWLPGTVVVWDNRVVAHSALFDWEDGQRRHLARITPQAEPPFETPFEGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYP4</accession>
    <name>B0XYP4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">AFUB_041619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041619"/>
    <dbReference type="HOGENOM" id="CLU_084856_2_0_1"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="198" mass="21711" checksum="00ADD88641E28F77" modified="2008-04-08" version="1">MLLSFFNRGPSPSPTTDSKKTSPAQSQQGSIPGSTEPQTQPQPQAQQTQSQPQRPLTNLKLLFGGVTFFALSLLITRRAFTKRVIASIPPYWTSSVYHRPPVNGAGDAFEALSLATLNVCSFAMMATGGVLYALDINSVEDMRRYVKKGMGTGTVRDEEVEREVEEWVAKVLGEKFGVELKKEKEKEKEAGNVEGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYW9</accession>
    <name>B0XYW9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_042360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042360"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="B0XYW9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090338">
        <property type="term" value="P:positive regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP53065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="197" mass="21993" checksum="0AFDD627CA35E7D5" modified="2008-04-08" version="1">MELCGRQKVVQRKMVLLGDGACGKTSALNVFTRGFFPTVYEPTVFENYVHDIFVDNVHMELSLWDTAGQEEFDRLRALSYEDTHVIMLCFSVDSPDSFENVATKWIDEIRENCPGVKLVLTALKCDLRKDDELNDNPNAITFEQGLAKAKEIGAVKYLECSAVQNRGIRETFYEAAKVALDVKPAGSSGSKGQCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZR9</accession>
    <name>B0XZR9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_045020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045020"/>
    <dbReference type="HOGENOM" id="CLU_581346_0_0_1"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="PhylomeDB" id="B0XZR9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="470" mass="52104" checksum="53684A51D0521940" modified="2008-04-08" version="1">MSSTEPNPALSTASDDHQSGKDDGSPKKIMVDSQPAKAKERSSKKRGRPQKVQDAQTPAERRRAQVRLAQRAYRSRQEATMVQLKNRIAEMESVIETMTEAFLAFSDTLMQSGVLNGSPDIAQSLKEVTAKYVTLSSQMTETDGDHAAPQDKALSQITASEQSSFHSADQTSQSSDSVVAVRTGSGDGDPGGAEPFGVLMPIETPGMANGSPFSITTPTDIRVLSPHFINIRTPMSHLDRPDSPFFAQRLHLAAYKLALRYLRNPDVPDSALLRNFGFLMTRWSRRQLISYLNSFLKSSDGVEVSRKFSIPLLNLGGAGLHYPQKHSPLGDPNLHWLPSAEDISMMYANGLSIQDLEEPWFDPEDVEGFLEEQGIILSNRNMFPAGLQSDHQDVVARTWQSGLWDDRAMFSRGHMFAVDEDQLINWLSHRGICLGRSPGFRKRDVERFISQHAWPIGMPLMPIQAVAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y009</accession>
    <name>B0Y009_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphoglucomutase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_045220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y009"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045220"/>
    <dbReference type="HOGENOM" id="CLU_045514_1_0_1"/>
    <dbReference type="OrthoDB" id="1743979at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03088">
        <property type="entry name" value="ManB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000043">
        <property type="entry name" value="Putative phosphoglucomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050060">
        <property type="entry name" value="Phosphoglucosamine_mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42946:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE (ALPHA-D-GLUCOSE-1,6-BISPHOSPHATE-DEPENDENT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42946">
        <property type="entry name" value="PHOSPHOHEXOSE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="9">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="186"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="293"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="8">
        <location>
            <begin position="435"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP53347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="516" mass="56513" checksum="ED9D590CB2DFD188" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y018</accession>
    <name>B0Y018_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allergen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_045310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y018"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045310"/>
    <dbReference type="HOGENOM" id="CLU_043430_1_0_1"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="PhylomeDB" id="B0Y018"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758504" evidence="2">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="264" mass="26487" checksum="6EB4FB53D2931200" modified="2008-04-08" version="1">MQFTKSLLLLAALTSSSLARLQGHERRQYATSASSTVAPSSSSGGSSAWTATPAGGSYSTAGFGGRTSNSGSGETYAGNVGNPWGSNIIEVSADSASNYKNVAQISGQNSEPWTVVFWNKIGPDGQMTGWYGNAALTLTLNAGETKYVAFDDDTNGGFAAAAGSIPKDSNGGYASTWGEFDFTSAGNGGWSGFDVSAIQAQNAGLTVQGMKICDALGGTCSSITPNAASVDNAYTTAEAAIGGIGGNLSGGGAVRLAVTIDYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y037</accession>
    <name>B0Y037_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_045510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y037"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045510"/>
    <dbReference type="HOGENOM" id="CLU_1209559_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0Y037"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758087" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="100"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="229" mass="23817" checksum="0A6EAC7F62014D90" modified="2008-04-08" version="1">MLRLPAFLGVICAFALGQTSKASSSAFEPDNFDVNAALYNLGVDVSTIPALTALQPQSTKSACRAACGALGFLYGPSRAFTQNTTAYSNATGSYWSAQQEEVRPDCIFQPSVNTDVSIIVLLARYTGCPFAIKSGGHAAFAGASSIQGGITVLLKDLNTITLNDNRSVVSVGPGNVWVQVYSALEPYGLAAIGGRVSTIGVGGLTTGGGISFYSNLYGWACDNVESFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0F8</accession>
    <name>B0Y0F8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_046040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046040"/>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0F8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="599" mass="66338" checksum="6C18A1E71113C78C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0L5</accession>
    <name>B0Y0L5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_057740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0L5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057740"/>
    <dbReference type="HOGENOM" id="CLU_000960_10_8_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0L5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="15"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="234" mass="24317" checksum="B9908607AEAE3876" modified="2008-04-08" version="1">MSRAQPVGSVKLYSVLAGIMIATFLISLDVSIIATAIPAISTHFHATTDIGWCGATYPLTMCALQPISGKLSSLLSLRWTCLAFYCVFLLGSLICGVANSSKMCIIGRAVAGAGGSGVVSGGLSVIALITTPQQRPLFTGLVTSLYALGPVVAPIIGGALAEHNWRWCFLINLPGGAVTVVTLLLFFHPPRNPIRSGVMLLPSVCTQVFGSLVSGILGKRRSSVSTEVASDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1X4</accession>
    <name>B0Y1X4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_050160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1X4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050160"/>
    <dbReference type="HOGENOM" id="CLU_088684_0_0_1"/>
    <dbReference type="OrthoDB" id="4510156at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760372" evidence="2">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="284" mass="28514" checksum="E71BD6F93258DE26" modified="2008-04-08" version="1">MILHSLLLVSALAGSSLAFSGHHSFTNSTTPSHHPSTHTLLPTGGGGGKPTHTGGTGTGTGTGHPQPTTTVVPGGDSGSVSTVTETITKTTFKPCSTPIHTQSGTTYYSTWLTTSTYETTTCYTTNIPTTIPASPQTTTVTLPGPGNSCPPPSTVTVTVTVSSGGDTGPHTQAPAPGGDSGSGPNPGTGTGTGSGPCKHCETITYTNTYGYTTTIVIPPISEPTSSATTRTTGTGTTTTKPTPPVGTGTAPGHSHTRGSPTGTGVGQAPTETKTWHFERRIVRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-03-23" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y224</accession>
    <name>AGALB_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable alpha-galactosidase B</fullName>
            <ecNumber>3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Melibiase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">aglB</name>
        <name type="ORF">AFUB_050660</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y224"/>
    <dbReference type="SMR" id="B0Y224"/>
    <dbReference type="GlyCosmos" id="B0Y224">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP51064">
        <property type="protein sequence ID" value="EDP51064"/>
        <property type="gene ID" value="AFUB_050660"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013093_2_2_1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="PhylomeDB" id="B0Y224"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000049">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000307">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393215" description="Probable alpha-galactosidase B">
        <location>
            <begin position="14"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="426" mass="47215" checksum="5CB8CBBEADB62F63" modified="2008-04-08" version="1" precursor="true">MSRSKTRQGKLPALGWNTWNAFGCDIDATKIMTAANEVVNLGLKDLGYEYINIDDCWSVKSGRDASTQRIIPDPDKFPDGISGVADQIHDLGLKIGIYSSAGLTTCAGYPASLGYEDIDAQTFAEWGIDYLKYDNCGVPSNWTDTYTYCVPDPGSKATNGTCPDNKNPAPAGYDWRTSLTAERYRRMRDALVSVDRTILYSLCEWGQANVNDWGNETGNSWRTTGDITPSWPRIAAIANENSFLMNHVDFWGYPDPDMLEVGNGNLTLAENRAHFALWAAMKSPLIIGTALDSISQDHLAILSNKILLKFHQDPVIGRPAQPYKWGYNPDWTFDPAHPAEYWSGASSVLGGTLVLMLNSEDTTQRRTAVWKEVPELKDVLGRQGKRRIGFRVTDVWTGKDLGCVRDHYSVELESHDVAALVVGRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y238</accession>
    <name>B0Y238_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_061140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y238"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061140"/>
    <dbReference type="HOGENOM" id="CLU_017392_0_0_1"/>
    <dbReference type="OrthoDB" id="5401486at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="576" mass="66069" checksum="C546E80793229FC9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y292</accession>
    <name>B0Y292_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endo-1,3(4)-beta-glucanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_061710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y292"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061710"/>
    <dbReference type="HOGENOM" id="CLU_039765_2_0_1"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="PhylomeDB" id="B0Y292"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760772" evidence="4">
        <location>
            <begin position="20"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="140"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="456" mass="51346" checksum="4424188E09C9E5A5" modified="2008-04-08" version="1">MKLYLLSLLPSLFTTTVLSYPAPSNSGTTSPRLAIDFYKRQCDCYVVSGSETVYFENYAFWDFRKIPLPRYDSNGSKVRIKRRSYTRSRADRTDKDEGDNEEGKVGIEENGDNEENLNGEDNADDGENDYNGMKAVGEGLDLGTLPFSHTAFARDWKPQEWHRKSNKYGPLPIINSPENIFFASNTLYTNDAESTHLVLRTTRFPNHTATAELEYHLRNIFHCSLRVRMRVMTVGSVNREPMLYGRPVLKGNPTSQSVVPIGACAGIFTYRSSTCESDIEILTSDPTNIVRYANQPDYDPITDAMIPGAASIGKLSQPWTNPTTHRVDWLHNITNWYADGEIKASNTYHVPDQPSMMAINLWSNGGEWTGEMPVGQSAYIGIEWIEVAYNTSTEVNGIPSDTVPFPSHKHRPFARSPELGSELDHETSAGEVEYIQRRDAARKCLRPCFLDDVRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2B3</accession>
    <name>B0Y2B3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_050850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2B3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050850"/>
    <dbReference type="HOGENOM" id="CLU_035263_2_0_1"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2B3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30478" checksum="01FE9B70A58D2ACA" modified="2008-04-08" version="1">MSSLHLELKDDDPWIIEVKIFKILRDYLQDPAASPAVAAQALDRLFPANRSDEDQPTDEPREDPGSFLWHFWGVVHNVAQQIPYTAPEQDRLAELIKALKGLSSQTKTVYLASWDHTFDLWGDLPLLGPTFREMYDCMVSLNDKEEREHWQSLNAYAARLTRDDSANLILFAKYSIEGMVEEVLELRLVDDGPRSILESRMVVAAEWVIQCGERLVAKEDEGLSIESWQRCKERFSSLLDNASMSPQTRERVQKAKQVMEALRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y361</accession>
    <name>B0Y361_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_053060</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y361"/>
    <dbReference type="HOGENOM" id="CLU_019796_9_1_1"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="PhylomeDB" id="B0Y361"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="402"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP51302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="472" mass="51484" checksum="1EC65DCB509DDB9C" modified="2008-04-08" version="1">MATSAREINIRRDLNVSQNPNLSTSPTASFQSAPSSHGGSAFAGRAIPLANAKHLKPFATEDIKVLLLENVNQTGRDILTGQGYQVEFLKSSLPEDQLIEKIRDVHVIGIRSKTKLTSRVLKEARNLIVIGCFCIGTNQVDLQYAAEHGIAVFNSPFSNSRSVAELVIAEIIALARQLGDRSMEMHGGTWNKVSAKCWEIRGKTLGIVGYGHIGAQLSVLAEAMGMSVIFYDVLNLMALGTAQQVPTLEALLSKSDFVTLHVPELPETKDMISSQQFEQMKHGAYLINASRGSVVDIPALIHAMRSGKIAGAALDVYPNEPAGNGDYFNDDLNTWASDLRGLKNVILTPHIGGSTEEAQSAIGIEVGQALVRYVNEGTTLGAVNFPEVTLRSITMEEPNHARVIYIHHNVPGVLRKVNEILGDHNVDKQMTDSRGDVAYLMADISNVDNATIKELYERLESLSSRIMTRILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3K2</accession>
    <name>B0Y3K2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl peptidase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_054490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054490"/>
    <dbReference type="HOGENOM" id="CLU_011977_1_0_1"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3K2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000020">
        <property type="entry name" value="Dipeptidyl peptidase III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="635" mass="72765" checksum="12D45DE613B1BFF3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3W5</accession>
    <name>B0Y3W5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein transport protein Sec61 alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_055660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055660"/>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3W5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="478" mass="52222" checksum="2F287892DC46980A" modified="2008-04-08" version="1">MSGLRFLDLIKPFTPLLPEVAAPETKVPFNQKLMWTGLTLLIFLVMSQMPLYGIVSSDTSDPLYWLRMMLASNRGTLMELGITPIISSGMVFQLLAGTHLIDVNLDLKTDRELYQTAQKLFAIILSFGQACVYVLTGLYGQPSDLGAGICVLLIVQLVVAGLVVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTINTGRGPEFEGAIIALFHLLLTWPDKQRALREAFYRQNLPNIMNLLATLLVFAAVIYLQGFRVEIPVKSSRQRGMRGSYPVRLFYTSNMPIMLQSALCSNIFLVSQMLYSRFSDNLLVRLLGVWEPRDGSAQLHAASGIAYYMSPPLNFKEALLDPIHTAVYITFMLVACALFSKTWIEVSGSAPRDVAKQLKDQGLVMAGHREQSMYKELKRIIPTAAAFGGACIGALSVTSDLLGALGSGTGILLAVTIIYGYFEIAAREGDIGSGLKGLVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y441</accession>
    <name>B0Y441_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-arabinitol dehydrogenase ArbD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_056430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y441"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056430"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="PhylomeDB" id="B0Y441"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="392" mass="42685" checksum="3CAC7E3017068A5A" modified="2008-04-08" version="1">MFRSTIFRQAAKAFSQRSHPAPFAAPLRCSASNTFFRPLSYTIPRSTGGKKDPEESEVEGRFARTDESVVIEYPNDADMPRTPIVQGRGGMHFKRTLAQFSLENKVSLVTGGARGLGLVMSQALVASGSDLAIVDLNPNASQERKLKTRLRSSSNSLRRKIRAWNSKSIGGFQAFLSVADANVLFTFLFSRMPNVTAHYADVANPDSVNTAIAEVISKHGRIDHLVTSAGFTENFDAISYPYDRMQKLWGVNVDGTYLFAVGVAKHLMERKAPGSMVLIGSMSGAIVNVPQPQAPYNAAKAAVRHLAASLAVEWAPHGIRVNCISPGYMLTALTRKILDERPDLRDKWTSLIPVGKMGTPEDLMGAVTFLLSDASKYITGADLRVDGGYTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y485</accession>
    <name>B0Y485_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CipC-like antibiotic response protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_056870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y485"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056870"/>
    <dbReference type="HOGENOM" id="CLU_143683_0_0_1"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="PhylomeDB" id="B0Y485"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="130" mass="15053" checksum="2643EAC0DEFDA467" modified="2008-04-08" version="1">MAWGWEQSDEAHREVYGERRHESSLSHELIAGAASFAGMKAWEDHQRKEGKPVSHAFAKEALAGFVGAEVDKLIETKGLDEADKIRARRHAKENAERMYDEHYVDRHGAPEYDPGRYPPHERFDRPVDRW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4D6</accession>
    <name>XPOT_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Karyopherin-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">los1</name>
        <name type="ORF">AFUB_057410</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP51727" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51727.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4D6"/>
    <dbReference type="SMR" id="B0Y4D6"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4D6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000343080" description="Exportin-T">
        <location>
            <begin position="1"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1032" mass="115410" checksum="C032B1D6D84EE4ED" modified="2008-07-01" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4F1</accession>
    <name>B0Y4F1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_068870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBCE family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4F1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068870"/>
    <dbReference type="HOGENOM" id="CLU_017716_3_1_1"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4F1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000008">
        <property type="entry name" value="Tubulin-specific chaperone E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001277">
        <property type="entry name" value="Tubulin-specific chaperone, putative (AFU_orthologue AFUA_4G11870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="13">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP50550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="629" mass="70928" checksum="346825E6D8162E4A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4K1</accession>
    <name>B0Y4K1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HMG box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_069370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4K1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069370"/>
    <dbReference type="HOGENOM" id="CLU_022445_4_0_1"/>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4K1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF5">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="196"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="196"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="507" mass="55735" checksum="EAD2410846E69DB7" modified="2008-04-08" version="1">MATAAATARFVQPPSPPQSTDGDLASQQCGMLNSLYCSQNPFVTSSLPRSAEAANSELNPQAMTYGPSSSPRYVSHEYSTPLPLQHTMPPSDSQINTPPPTADEGVVPSKLEATPPRWPSSSALKLSPGKVRVAKPPRIRRRAKKASNRESKPKLPGPLSEVTKHLTNVPLRDMDSWVHRPKEVRHAEVAKKNGKVARPMNSFMLYRSAYAERTKEWFAQNNHQVVSEVAGDSWRIETPEIREKYEVLANVEKANHLKAHPGYKFSPSKEKKKRSETDDDQLTVDGGEMTSGSSPAFLQVRAVGSSEVDSNGWASRDSTPFDFPEHGLPTTTYYDSSWQTSHPSMSAPKPSPYLQQPIHPNLIGPPTEDSRFKHVGLQNIQFTSSTVLAGLPGAAHHDLLQPQNNSGAGPDGQLDPQLLSLSDHSGQRAMYNHSHYAIWQEVPTSNCYVPVPSPLQSTYHVGATYHQGLQTLGDSRDTWDSINNETSFDASNGEFEHWINSQASGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4L8</accession>
    <name>B0Y4L8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase 4 core regulatory subunit R2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_069540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4L8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069540"/>
    <dbReference type="HOGENOM" id="CLU_024587_0_0_1"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="40593" checksum="ACC1E7934E97BEB6" modified="2008-04-08" version="1">MVEPLLERLEHNVYNAFPMPKFHVETQSPAAQQQPSSFSQEPNSVPPSSNQENTPPTETENPSHSTIPASAATPSPSDERVPDSKPQSVVDSPADTLPPPLVLLLDSIKSTLKTFFASKPPHTIQRLAELVLRPNAHYRTLPAYLRAVDRVVSVTSTADIFPLQTEPSAGQVNGVLNGGGHGFMFPDHAPGSDESLGGALLTPIPWLTGASSPDNDGGATLSEGLVPGDSLSLATQTSQPEQVQQQAQDPIAQTQSSEMTAQNETMVGASPPPVDSSEEIPHARGPPIVGVEDMGLQDGKGVEMTLAQDANAPADQSSAPTDQPRSTADEQTENQKPASRANADSDGDIQLDDVKEAGESAPAATATGAAAEAEANETLQTTENKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y508</accession>
    <name>B0Y508_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_070980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y508"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070980"/>
    <dbReference type="HOGENOM" id="CLU_1288638_0_0_1"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24415" checksum="0FD38FA1C52DD467" modified="2008-04-08" version="1">MSPTDSCAACSWTSERQKYCNYKSYVKLFYEAGDRGVWSLGSNLILKDRGASLPTFEVPNIQFVQEKTSIPVPTIIESWEEDEHTLILMKRIAGEPLNKAWPNLSMDEKENIARQTADLILYKPLVAVQSIRISSFLIKCLSFPTVLWDLMMNSGRRWSVVCKKLCPRLRAFDSEVYGGSMWVLQFLTVRKIGSGRHYYGSICRTIVQRVNSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5F4</accession>
    <name>B0Y5F4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_063210</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP49989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063210"/>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5F4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP49989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="306" mass="33817" checksum="DA6F9EB9291149B0" modified="2008-04-08" version="1">MTRGTNLVGPFLQHDAGLDYYGRRLATCSSDKTIKIFEIEGETHRLIETLKGHEGAVWCVAWAHPKFGTILASSSYDGKVLIWREQHQNATSPVAGSTWTKVFDSSLHTASVNMVSWAPHESGCLLACASSDGHVSVLEFRDNSWTHQIFHAHGMGVNSISWAPAASPGSLISSNPGPGQQRRFVTGGSDNLLKIWDYNPESKTYNLSQTLEGHSDWVRDVAWSPSILSKSYIASASQDKTVRIWTSDASNPGQWTSQQLEFDTVLWRVSWSPSGNILAVSGGDNKVSLWKENLKGQWEKVKDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Q6</accession>
    <name>B0Y5Q6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_064230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Q6"/>
    <dbReference type="HOGENOM" id="CLU_001477_0_1_1"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Q6"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="411"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="9">
        <location>
            <begin position="674"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1220"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1227"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1239" mass="139762" checksum="9677620BF6888FB8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5T7</accession>
    <name>B0Y5T7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_064540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064540"/>
    <dbReference type="HOGENOM" id="CLU_028200_12_2_1"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5T7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="13"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="320" mass="36179" checksum="3A22D86335395C05" modified="2008-04-08" version="1">MYSKLFITKAPGWEDSYVVITFEADKYGNGIHIWEVDESDLRRYSKWANTSQIVYGPLIFITKLSILLLYLRVFAPSFRSKTFFCIHALIWLNFGFYFADTIVKIFECSPRAKIWDKTLKGHCININIPIIVTSSINVASDFLILVLPIVSVWRLQMRDSKKLGTSMIFAAGIFACMCSIMRLVVSVQNRTVEDKTYDWFPEFLWTYSSRSAKRAIEVISWPTSWSVRQKKQSSGGHSMTELCQSTNCELDDIEQQPEEHTGRIFSGASYTTAGAQVGILELPNVASGSYTFESRGAGLGPNYRSGILKTVEVDVASQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Z8</accession>
    <name>B0Y5Z8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoinositide phosphatase (Sac1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_065150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Z8"/>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Z8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072517">
        <property type="term" value="C:host cell viral assembly compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="668" mass="75376" checksum="83E78B4C530DA793" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6A9</accession>
    <name>B0Y6A9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anion exchange family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_066270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066270"/>
    <dbReference type="HOGENOM" id="CLU_002289_7_2_1"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6A9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046713">
        <property type="term" value="P:borate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF38">
        <property type="entry name" value="ANION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="8">
        <location>
            <begin position="32"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="8">
        <location>
            <begin position="207"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="601" mass="67946" checksum="88DB188205009BB2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7E9</accession>
    <name>B0Y7E9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_073570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073570"/>
    <dbReference type="HOGENOM" id="CLU_082475_0_0_1"/>
    <dbReference type="OrthoDB" id="5344006at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35240" checksum="A5FBF5CCFB9B0C81" modified="2008-04-08" version="1">MLCPVSMTGLCRRPQRFHPRPQEMRSKSVKPSLYPPVPFHTIRAISLLSSVIVGIILAVFIYHLKSGGYKLPWAFLLLLVSAFLSILNYVFTSLTHCFYGLSPRLSLLSNTILLILWLISLGLLSWSMSHTILTTCNATYWATSTGIAVCRTYKALFTFTCTSTFAAIAAVALDIIIHKRQTRLGQYDPMTSNPDIKLHERNNSAVTNTNASVPLDDERHPLQAQHQFHDSPYTDRHGISDIPGSGYADHPAYRVPPPVYGLSASAEHYHAGEAHEFSETAPARSQQGGPRVRFSGVGRPEYGYPAEQKAYDSGTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7F0</accession>
    <name>B0Y7F0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_073580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7F0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073580"/>
    <dbReference type="HOGENOM" id="CLU_029499_3_1_1"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7F0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="11">
        <location>
            <begin position="219"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP49331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="425" mass="46984" checksum="B9A9A0FF3D055D35" modified="2008-04-08" version="1">MNPSSVISSKTPARSSPRGLYHFRDAILKGKPERIFVLNADVCCSFPLGEMLKLFEEKDAEAVILGTRVSNDAATNFGCIVSDSHTKRVLHYVEKPESHISNLINCGVYLFATECIFPAIRSAIKRRTTRPRLLSYPSSENLEASFVAADEETEKSEVLRLEQDILSDLADSNRFFVHETKDFWRQIKTAGSAVPANALYLQKAFQAQSDELTPPSATIVPPVYIHPTATVDPTAKLGPNVSIGARVVVGAGARIKDSIVLEDAEIKHDACVMHSIIGWSSRVGAWARVEGTPIPMTSHSTSIIKHGIKVQSITILGKECAVGDEVRVQNCVCLPYKELKRVCYLALLHFLTTLTLVNRMLPTRLLCSETFKKDCSKLDLFDGLYIFLVTTNPFDSSINTLYSKPFSWTLDNVDHLGARTAIILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7G6</accession>
    <name>B0Y7G6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Copper fist DNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_073740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073740"/>
    <dbReference type="HOGENOM" id="CLU_022327_2_0_1"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7G6"/>
    <dbReference type="PHI-base" id="PHI:8153"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="665" mass="72532" checksum="70CA17B2D7A5B904" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7Q6</accession>
    <name>B0Y7Q6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_074640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7Q6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074640"/>
    <dbReference type="HOGENOM" id="CLU_030733_2_0_1"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7Q6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP49437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="489" mass="52784" checksum="D7EBBB6A703D3FB4" modified="2008-04-08" version="1">MANSFPLRVLPTIDPSAGHTFITPSKRIHESEDVSEFLISKAYVDIMTFLLQLNRAMIPVKLADGTVQSWPINTDAVEFSAPVRQLQQLLTKLEELLAEAPPDTGPRRFGNISFRRWYELVESRASELLGECLPSELLQAKSSDPNSVTAEAELKAYFLGSWGSPQRLDYGTGHELSFLAFLAGIWKLNGFPKTTPGVEERAIVLGVIQPYLELVRTIIKRYTLEPAGSHGVWGLDDHSFIPYILGSAQLAPAISETDPTPEEGSLPGAPSPNGVTKAHIVERERLTNMYFSAIGFIYDVKKGPFWEHSPMLYDISGIQAGWGKINKVSLVALAGNDQLLIIQGMIKMYNAEVLSKFPVVQHFPFGSLFSWDRDPNAVPPPTSAHMSTTQSQSRGPAVPSAGQTPPSGTRAPWATATQAAPPAGAGTAAPWAAKRDGCTPGKPPTSLPDTSRLPPGPMAPTRAPWAASSTGQAPGGDPTHVPTKAPWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7U3</accession>
    <name>B0Y7U3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_075010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7U3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075010"/>
    <dbReference type="HOGENOM" id="CLU_065464_1_0_1"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7U3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000009">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="156"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="253" mass="27865" checksum="8C3ED72E9DCE5E79" modified="2008-04-08" version="1">MSNLLPQSCLRQLTRSPLRQTSLPLFLAPAYTHPLRTQCFSTTSPTQSRVGGAPISIPPEVSLKFVDLPQTQVRGRSKEVPKTAIEVKGPLGELTLNIPPFVEVTHDETLRKASLTVQDPSIAHQRAMWGTMRAHLQNYVLGVSEGHICILSLVGVGYRASIESTATTVEPEYPGQQFVSLKVGYSHPIELGVPKGVKASTPQPTRILLEGVDKNVVTQFAAEIREWRKPEPYKGKGIFVNGETIRLKAKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7X7</accession>
    <name>B0Y7X7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_075370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7X7"/>
    <dbReference type="HOGENOM" id="CLU_1277354_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="216" mass="23762" checksum="7267B80AF7ACEE29" modified="2008-04-08" version="1">MVVLQCKNQAFPHRGNASGWGGGARECFISPITVIPTWSESKSGSDATALCSLLNCLNAKARRSRGHGLPQWPSGNRGHRESVASAEYGGPLTLLKTYLFPQRAATCQHLQPFISIDFLFFPSYIFPESYASADDNPDEVVFLRLLSRHPKIKACLSLILSVLSSLAPAEALLLLQEVHNDSEALDTFQVWNESLLQASDPIRDEPHPTWETDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y808</accession>
    <name>B0Y808_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase GliI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_075690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y808"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075690"/>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="PhylomeDB" id="B0Y808"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF32">
        <property type="entry name" value="AMINOTRANSFERASE GLII-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="76"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="435" mass="48187" checksum="DEEE3E505B7A27E3" modified="2008-04-08" version="1">MPSETITPLLAHRARTNIQWFTHKHMRQVSRLNAKQHRVNMMTAENWSIRDELVDQYKALFAQHLSPRHLSYADGMGGDAELLQAAADFFNRVFAAHSRVQPAHLVVGAGCSSLLENLLYDICEPGEGVLIETPFWGGFETSFVLRSNVTAVHVRPPCHGNGSADLDRLVSAYIEAYERALRQAPCRIKAILVCNPHNPCGHIYPPRVIQALLQFAQRHDLFYISDEIYALSTLDEQTAFTSVLSIDVAALGVDLARVFTLYSISKDLGSSGLRLGFGITQAHPDLRLSLAISNHSRVSTFTSLVITALLHDPEAATAILHQNRAALQRSAKLISDFLAFHQIPFVPPAAGVYVWARLGWRSSSRPGDEPSWDEEARLNDRFEAAGVSVGAGQGYCASEPGWFRITFAIPREELVAGLRRIEQVVGMEGQKWTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8P2</accession>
    <name>B0Y8P2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonribosomal peptide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_078040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8P2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078040"/>
    <dbReference type="HOGENOM" id="CLU_000022_60_3_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8P2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="642"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1160" mass="128658" checksum="ECC5F0D39E11DA84" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y928</accession>
    <name>B0Y928_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_079420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y928"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079420"/>
    <dbReference type="HOGENOM" id="CLU_011226_15_4_1"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="PhylomeDB" id="B0Y928"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000106">
        <property type="entry name" value="Glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="87"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="222" mass="25161" checksum="35635829A843D760" modified="2008-04-08" version="1">MLIVHHLQRSQSERIVWLCEELGIPYELRTYQRDAKTLLAPPELQQLHPTQAAPVIQDGTTTLAESGAIVEYILTKYGKGKLTVPPTADNYADYLYFLHFANGYFQPALVGYSTVLRSEISRDDPSARFARRNFEQALRILDDRLAKHTWLAGEEFTAADVMNVFTLTTARLFFPYRLAGYEGILGHLQRVSQREAYQTAMAKGDPGLIPLIHGDNPRPIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y986</accession>
    <name>B0Y986_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_080140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y986"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080140"/>
    <dbReference type="HOGENOM" id="CLU_637737_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="430" mass="48219" checksum="800858708B07C775" modified="2008-04-08" version="1">MITEEVLKAAAGNEGSGEKVLALLEKSQDGMGMQAKDELIWIRKLQSTGYSLQEIANLLFDEEHDTPWIYFEPAERAQFVIQPNRHVPRCSHHYCSDEQESSEDSQKWLPKEGSAADDYGDVIETVEELCGLAGISPTTRTKSDWFGSVDFSEGNQLAAVSYTLATDETHMLSVHGLWSRISQALEKFCCAAGLIQARNLCCNSFTFLRLRNENHEARAKIPGEVVRVDFRLIVDLAEALRSAQDPISELLSASEAILVLVSPIITDAHGARDLHLCLQLCALAVQFLCLSFLSFTKAHIGAIHPFFLDAPLRQVTLQGLGKQEHFPYIVAELVDLTCLGGMTRGPVLMFHAGKYLAQVQDPEMATSRQNVGQVRYFRPRRRCAGHLGTREFCVSERHARTSSCHKTRRRIYLRQQKREMSLGAWDGRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9E5</accession>
    <name>B0Y9E5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9E5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080750"/>
    <dbReference type="HOGENOM" id="CLU_066707_0_0_1"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9E5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28485" checksum="BD83FCA5F09446CE" modified="2008-04-08" version="1">MNSQRIAYFGATGGCTNACLALSLRQGLKAVALARTPKKLHDMLLSQGISEETISANLIIIQGDITDVAAVKKTLMSGDERKLVDKIVSGVGARPSFQLSVTTPVKMDNPHICEQAITTIIKALGEIYAEYPDERLCKPVITVISTTGVDGPDDVPFGFKSLYSVLLAVPHEDKKKLEELVKSDELKDASSRVFGGAVIVRPSLLVGDHQIASIGAKKLRVGTEENPPIGYTVHRARVGQWIFEEVVTKSKVDWVGKIVTLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9R4</accession>
    <name>B0Y9R4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_082000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9R4"/>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9R4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000705">
        <property type="term" value="P:achiasmate meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061586">
        <property type="term" value="P:positive regulation of transcription by transcription factor localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="497" mass="56255" checksum="333C7136B3ED0BCE" modified="2008-04-08" version="1">MVDREPGTPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHFLLSTNDKTIKLWKVFDKSLKVVAENNLSNELTPAGAVGGGGAPRAPRLSFKDASALKLPRMTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPISCNWFMYASSKGTIKLADMRQRALCDEHSKLFEQEEDASSRSFFSEIISSISDVRFSHDGRYIVSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAENVMTGSYNNNFMIYPTDPSKETEIVLQADKSAFKAKKVGVPTPMNKNGKKNGSRAGSPAGPGSRMKKETDADQIDFNKKILHMSWHPYEDSIAIAATNNVSILALHFPSCYHSCDFAKVLIQSEQLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9T4</accession>
    <name>B0Y9T4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_082190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082190"/>
    <dbReference type="HOGENOM" id="CLU_089740_1_0_1"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9T4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="204" mass="22977" checksum="439851F4B78C9849" modified="2008-04-08" version="1">MATSEPKVPVYSINDLKSTTDDALVPYLCTLPQPYTFKQDHSKSNVRFLLGYSAVAIAAFTFYADRKLGWEATTSPWVIAAVCSYFILNTGLTFWIWAVEAGEVFRGKRESGETISIRSSVKKHSPLYKLRVQYTSPSNKILQEKEIDAPFMNWFSADGTFHPEPLRRWLSTEIEVLRLAAKETERKTGGVGSVVGVQDTKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9X8</accession>
    <name>B0Y9X8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_082630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9X8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082630"/>
    <dbReference type="HOGENOM" id="CLU_074173_2_0_1"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760544" evidence="2">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="237" mass="23382" checksum="EDE93C380728C948" modified="2008-04-08" version="1">MRSNAIRSLTLLTATVATAAAESTVSLFLPYVDTQSLVAEVLGSKSSLLIALQDHPSDVRTQSASATTYRVNCVSAGDDCGIPSSGFTVIQGASTVQQAYTYDDYNVAFGCNLGGTTSISCLVSQTDSTTTHVTATAMITDIGSFFLPVVVTGTATAGAHATTGASVTGATPSATGQTTLATSGPSVTSGPQATGSSASASATPSHSSSGNAAIPQITGNANWAIGGAAMAMALALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA41</accession>
    <name>B0YA41_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA maturation protein (Nop14), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_083330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083330"/>
    <dbReference type="HOGENOM" id="CLU_008874_0_0_1"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="PhylomeDB" id="B0YA41"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="913" mass="104147" checksum="678E8F5543635ABC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAE9</accession>
    <name>B0YAE9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease GabA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_084430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084430"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="PhylomeDB" id="B0YAE9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="557" mass="60842" checksum="C7BA424F6359FF30" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAF1</accession>
    <name>B0YAF1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_084450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084450"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B0YAF1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000032">
        <property type="entry name" value="Probable aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="316"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="510" mass="55027" checksum="CA37C772A46B1D99" modified="2008-04-08" version="1">MIFVLAPLCRHSMACVHQIACLTHDLANVFLQNFFNIINGETVSSAVTQHGINPANKEPNPPVPVASPAELDKAVAAAQVAFEQWSPFPLEDRRKALFAYSDALNAEKDGFTSLLTKEQGKPLSQAAMEVEMAVAWIKGLASLEIPEVVLENSSERKIVQRFTPIGVAAAIVPWNFPVLLAIGKVVSALITGNSIIVKPSPFTPYTALKLTELAIPFVPPGVFQALSGDDQLGPWMTRHPGILKVSFTGSTLTGKRIALAGAETFKQCTLELGGNDPAIICKDVDLDALVPKGDQNLGQVEDKLLMLDPTRVAPLCFLNSSQVCMMIKRLYVHESIYEAFRDKLAAHVKTLPVGNGVQPDVFLGPVQTEMQYNKARDLLSSISAEGLRPALGGTVEESAGYFIHPTIVDNPPDTARVVTEEAFAPILPLLKWQTEEEVIARANADPAGLGGSVWSRDLDQAQRLASRLECGSVWINSHFAVAPHVPFGGRKESGSGVEWGVDGLKAYCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAI7</accession>
    <name>B0YAI7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_084809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084809"/>
    <dbReference type="HOGENOM" id="CLU_2721772_0_0_1"/>
    <dbReference type="OrthoDB" id="4377801at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760811" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="76" mass="8820" checksum="072BEE08DC8565D4" modified="2008-04-08" version="1">MQFSSLPFCRWRWLLLLNLTLLGDDDVAVPKAVSLLSQQEIFLLIDPYELVDGKLDCYVNFYLLEPCSIINGRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAL0</accession>
    <name>B0YAL0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase, classes I and II family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_085030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAL0"/>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B0YAL0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="70"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="383" mass="42052" checksum="FA9B6247275BC1EC" modified="2008-04-08" version="1">MLSARGETYAKAGLANSYLEALKTPYNKDNKQGVVSFRNAENVLSHILLLVASRLDHSDLTYHEGPFGSRRLRAAMANHITTYFHPATPISPDHIIFANGVTSLNALCALSLTDPGDGILLGQPIYGSFNGDLRVPSGCQLIYTSFHGDDQFSPDAVTRYEEAFLQARETGVTARALLICNPHNPLGRCYPRETLEALLQFCQKYQLHLISDEVYALSVYDDADSTDGFVSVLSIDPVPLGVDPALIHVLYGMSKDFASSGLRLGCLISRNERFLQAVLSMSIAAAVLEDQGFVESFLQKSRRLLRSQRDLAARALDEAGIPYAQGAIVTSQDGWAAELALSRQLQQIGVEMSTGYAYHNEVPGWFRVIFSLDEESLKEGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAP1</accession>
    <name>B0YAP1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_085340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085340"/>
    <dbReference type="HOGENOM" id="CLU_019706_2_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="PhylomeDB" id="B0YAP1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760910" evidence="2">
        <location>
            <begin position="20"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="69"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
        <location>
            <begin position="363"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="527" mass="59187" checksum="5DAC3646727A8FCE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAS2</accession>
    <name>B0YAS2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_085640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085640"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B0YAS2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="78"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="585" mass="62892" checksum="9A6D081BDD8064EB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAU2</accession>
    <name>B0YAU2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription regulator (RTG2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_085840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085840"/>
    <dbReference type="HOGENOM" id="CLU_033165_0_0_1"/>
    <dbReference type="OrthoDB" id="2014654at2759"/>
    <dbReference type="PhylomeDB" id="B0YAU2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000046">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000007">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="61"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="2">
        <location>
            <begin position="377"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="602" mass="66673" checksum="8A8C3E05BBC58717" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB08</accession>
    <name>B0YB08_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_091150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091150"/>
    <dbReference type="HOGENOM" id="CLU_2222656_0_0_1"/>
    <dbReference type="OrthoDB" id="5809458at2759"/>
    <dbReference type="PhylomeDB" id="B0YB08"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="106" mass="11870" checksum="A1F0270A79A75866" modified="2008-04-08" version="1">MRSKILAALPWPVQVVVGNIIYRKVTRNLQGQGTMAFTEEEISEFRQEIWASLNAVVAEAQKKQSDRDRPFWVWGGEGPTEVDAGTGHKRDHQGVSCCGRLCETDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBW2</accession>
    <name>B0YBW2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_088030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088030"/>
    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="PhylomeDB" id="B0YBW2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="259" mass="28305" checksum="9435B21F9A70199C" modified="2008-04-08" version="1">MADAPRGRGGFGSRGDRGGDRGRGRGRRGRRGGGKEQEKEWQPVTKLGRLVKAGKITSMEQIYLHSLPVKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAVVVIGDSEGHIGLGIKTSKEVATAIRAAIIIAKLSVLPVRRGYWGTNLGEPHSLPVKQSAKCGSVSVRLIPAPRGTGLVASPAVKRLLQLAGVQDAYTSSSGSTKTLENTLKATFLAVVNTYGFLTPNLWKETKLIRSPLEEFSDVLRQGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBZ6</accession>
    <name>B0YBZ6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_088370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088370"/>
    <dbReference type="HOGENOM" id="CLU_030057_6_1_1"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="PhylomeDB" id="B0YBZ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000005">
        <property type="entry name" value="Sulfite efflux pump SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="374" mass="41703" checksum="BB525DCF6A6B1BBF" modified="2008-04-08" version="1">MSCGNTNPRTQTQLTKHDVGWRRIVRNFTPSWFSVTMGTGIVSILLNTLPYNAQWLYWISVVIFAINVLLFITGCIISFLRYTLYPEIFGAMIVHSVQSMFIGTFPMGLTTIINMFCFVCVPAWGEWTRNFAWGLWIFDAILSVVTALSLPFLLYVFPLFQTYPTVTLKSYSMAHGNETQLSSMTAIWLLPIVSCIVAASSGAIVADVLPNPQHALWTVLVSYVLWGIGVPLAMMVMVIYLQRLTLHKLPPKAVIVSVFLPLGPLGQGGYGAMKLGKSAQTIFAQTHTLEASSGSTFYTLGFLVALILWSFGLVWLFFASASIARCRSFPFNIGWWGFTFPLGVFAASTCQMGRELPSEFFKMLGTVRRSYNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCT8</accession>
    <name>B0YCT8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycogen synthase kinase (Skp1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_093160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCT8"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="PhylomeDB" id="B0YCT8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="53"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="412" mass="47080" checksum="4BC55AAB0A111134" modified="2008-04-08" version="1">MSQNRPGVFSNLRMGENITQEPVELTALLSDHTEVVREKVQDGLTGETKEISYSQCKIVGNGSFGVVFQTKMMPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGERKDEVYLNLVLEYVPETVYRASRYFNKLKTTMPMLEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPSTGILKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRRAPHEAIDLISALLEYTPTQRLSAIEAMCHPFFDELRDPNTRLPDSRHPGGAARDLPNLFDFSRHELSIAPALNSRLVPPHARAALEARGLDIDNFTPLTKEEMMARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCV0</accession>
    <name>B0YCV0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_093280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093280"/>
    <dbReference type="HOGENOM" id="CLU_016574_4_0_1"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="PhylomeDB" id="B0YCV0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="230"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="687" mass="76118" checksum="E9EE4705D720FC65" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCW8</accession>
    <name>B0YCW8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HATPase_c domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_093460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093460"/>
    <dbReference type="HOGENOM" id="CLU_001744_1_0_1"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="PhylomeDB" id="B0YCW8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="32"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1424"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1764" mass="196747" checksum="3021C8DB51638AD4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE52</accession>
    <name>B0YE52_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_097870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097870"/>
    <dbReference type="HOGENOM" id="CLU_000134_18_0_1"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="PhylomeDB" id="B0YE52"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29664" checksum="F4135180A28B558B" modified="2008-04-08" version="1">MLVQLPPELILLIAANLGRATDISSFARTSRAIYHQLIDFLYKVSQDNGERQPLLWACSEGEERTLELAIQNLEKGRTNIDVYGKALAQASASGHSKIVSTVLQKVKPLLVCDYWVDVALREAARHGHQSVVQLLVGEGADIDVCDPDGTPLIHAVAGGHGDVVELLLKNGASVHRTNKIGRTALHAAACKGDIKTVEDLLKHGAKVDEEDAYGRTALFLAVFGHKDVVEYLLNKGAKAHRKYCCDDTALQVAEEWKTETSLISLGDMQDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEC6</accession>
    <name>B0YEC6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_098700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098700"/>
    <dbReference type="HOGENOM" id="CLU_133919_0_0_1"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="PhylomeDB" id="B0YEC6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="1">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="111" mass="11351" checksum="08C9DDFBF121A95F" modified="2008-04-08" version="1">MVHPSSTCCKTSGDGSCVCAAQAKCSCGKENALHCTCSRSAIENTISGPRCSCRARPAGQCTCERAAAENHPVTGDACPCGKRPSTSCTCEKVSAVDAAAEAIETDFTTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEG5</accession>
    <name>B0YEG5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS drug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_099100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099100"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="B0YEG5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000525">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="535" mass="57331" checksum="FB92BF77BFFB943D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEH5</accession>
    <name>B0YEH5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_099200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099200"/>
    <dbReference type="HOGENOM" id="CLU_058864_0_0_1"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="PhylomeDB" id="B0YEH5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760962" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="124"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP47319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="296" mass="31299" checksum="E70F665624164247" modified="2008-04-08" version="1">MRSLNFLSLLSLLLLLGTISSAWPWPQDGLNMAHGEIVARADTTASDETKTDSKASKTDSASDTNTADSTATDSSSGKKTSTGTAKETGTQTESGTSTETATDKSGKNSKTKTSTKSTSIDPRLPAGGTSMLIPTAGATTYYKIGDYVTFAWNYTSLLVTPSAVNVLATCTMNSATYTLTSNMSVEETGKVVWDTGKYQANATVPLLTATYTLYVVDVDKDIGDTASPGHLGSQNGYLFGMYSPQPYTPLNEFNCATCNSALSDVERQALKFALGMVMITIASFTWFAGDFGVFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF07</accession>
    <name>B0YF07_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_101150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101150"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_1_1"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="PhylomeDB" id="B0YF07"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="362" mass="40996" checksum="87E65B77438D09F6" modified="2008-04-08" version="1">MVALYDAFGFPIVRDQLIANTVLVALATLAVLLRFISRHIRKSKIWWDDGCCVGSMLHTYGMLAMHYHYARVGMRKHVTEIPPENLVAMLKMLIVYQVVYYNAMVLAKLSYLFFYLRIFVTKGFRIAAWVCMGCACAYWTGSMLQIFFICQPFQKNWNPTLPGHCASQNVAFSTIGAFNLITDVMIMVLPLHFIWKLQMSTATKLALYGIFGLGLFISAITIIRIRVLTTVDFFDLPYSMIWAAFWSVTEPALANLNACVPMLRPVFKAAFPTLFASRKMYSTQPGSGASGIKNKAFKRMNEVESDLQLTNLTQLEPVRTSREGRISEHGDDGSHDDRSQDGRSQDESTHVPRSVIVNRPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF27</accession>
    <name>B0YF27_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_101350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101350"/>
    <dbReference type="HOGENOM" id="CLU_093521_0_0_1"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29707" checksum="D1EC0785F93D37EC" modified="2008-04-08" version="1">MSAIIQFPSLCSANSVFYPGQQKDRQEEAVDSRKGSGEYMKSPNGKRLRKKSAEVGCQDRDKVCILTNYSKDICQPCPLYPVWMSDENTDVMRQFFEGLRQVWSDEKVDEWYNAIYGDVSGPEKPENLVLLSPDAYLLFTKGYIAFEPVDKDPEGMWLSLKLWWLQRDEKDNVDFSIIPHLPSDLNPSEYGIALHDVCNDSPLLSGKTITLNTHDPQNYPLPDTRIIEMQWVLNRVLALSGSVKPNALDEWHEVADEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF86</accession>
    <name>B0YF86_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_101920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF86"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101920"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_2_1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="PhylomeDB" id="B0YF86"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03178">
        <property type="entry name" value="GST_C_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF14">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="99"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="230" mass="25097" checksum="1CD1A3344DFE31A2" modified="2008-04-08" version="1">MAPFTLYTHAGPGPNPVKVAMALEHLGLDYDCIPLAFGEGKGTVKDPEYTSKVNPNGRVPGLIDHENNDFTVFESAAILQYLAEKTIQYDTSGKLAGSTPEERATVNKWLAWQVSGLGPYQGQLVWFLAFHEGAHGEKPNGSVIARYQAEVERLRSVLEKHLASAENGFVALGRLTIADFAILPWLKISVLAGSALKSFEEYPAINAYIKKLDALPEVQAAYKKAVPPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJN4</accession>
    <name>H9CJN4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">ATP synthase protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_m0090</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="16"/>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase protein 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353053.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJN4"/>
    <dbReference type="GeneID" id="11948082"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009230">
        <property type="entry name" value="ATP_synth_su8_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36101">
        <property type="entry name" value="ATP SYNTHASE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36101:SF1">
        <property type="entry name" value="ATP SYNTHASE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05933">
        <property type="entry name" value="Fun_ATP-synt_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 15" id="KW-0138">CF(0)</keyword>
    <keyword evidence="8 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFE02834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="48" mass="5788" checksum="DB42E91E896D3D22" modified="2012-05-16" version="1">MPQLVPFFFVNQVVFAFVVLTVLIYTFTKYILPKFVRIFISRIYINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XML1</accession>
    <name>B0XML1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_003130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XML1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003130"/>
    <dbReference type="HOGENOM" id="CLU_698240_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="395" mass="44112" checksum="AF65EEA9FA321B10" modified="2008-04-08" version="1">MCIQRKSSPRTLGTPYYVGRNNRLHSGRHPILVNQDPEEAWALGYDDNSNNESFFGFHGERFVPLAVEETFVTVQAETEYSLAKALGIGQLGYFYLIQDRVAGIDGTVVALSETCVQVPFHRLVTITNQADLNSPCFQASHETSSHRLCYQTSPQIQLREKETQRNRCQKLVLHASVSYDLAPGKGPASLNQRLERCLPCSCSIRRLDYLFQNVATLTSAESIRNATQCLVDAVTVANKVSNDHNGSVLKGNEIVSLKRGPKINAVVDWKSGQIIPSRIRSMEIDQTFVDNKKYLIIGLAGDLGRSIARFMVERGSPYDITLEMSHNPNKNPLITVKLQKERYGPKDAEAVTDAHLLIVSIFSRNPVLRVEDEMLDQGPNRGLDVPTVQGIYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNC7</accession>
    <name>B0XNC7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FG-GAP repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_004489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004489"/>
    <dbReference type="HOGENOM" id="CLU_079970_0_0_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="B0XNC7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46580">
        <property type="entry name" value="SENSOR KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="216" mass="24066" checksum="393FC4B27BC81CAA" modified="2008-04-08" version="1">MQTRPLSINAIWHLLIDADGDGRDDLVYIKTRNTGTGRVEVHIATAASNFQTRIKDVGTTFLPEDNGTWQMADFDGDGILDLIYIKTRNTGTGRVEVHVASGASNYQTRIQEVGTTFYPEDNGVWQMIDFNRDGKLDLVYIKTRNTGTGRVEVHVASGASTYKTRVQEVGTTFYPEDNGFWQLIDFNKDGVLDLAYVKTQNTGTGRIEVHVANGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNG5</accession>
    <name>B0XNG5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lactam utilization protein LamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_015070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015070"/>
    <dbReference type="HOGENOM" id="CLU_069535_1_0_1"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11665">
        <property type="entry name" value="LamB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003814">
        <property type="entry name" value="PRK05406.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003816">
        <property type="entry name" value="PRK05406.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="253" mass="27867" checksum="9CABAD59C4D7E44E" modified="2008-04-08" version="1">MAPIQQKALINCDMGEAYGNWTCGPDLELLPMIDIANIACGFHGGDPLIMMETVRNCKAHNVRIGAHPGLPDLQGFGRREMKLSPEELTAITIYQVGALQGFLDREGVPLHHVKPHGVLYGMMCRDYEVAKAVMLGIPKGVPVFGLAGTQMEKAANDLGIEFWAELYGDVKYDSNGMLVIDRKKKPWNLADVEKHVRQQIEEQSVTAVDGTVVQLPLKTYPVSICCHSDSPGCVDIIRTTRKVADEFNAKHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNJ1</accession>
    <name>B0XNJ1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2C, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_015330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015330"/>
    <dbReference type="HOGENOM" id="CLU_009813_0_0_1"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="PhylomeDB" id="B0XNJ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000098">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="417"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="865" mass="97338" checksum="547E453DC4766702" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNL0</accession>
    <name>B0XNL0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Crh-like protein</fullName>
            <ecNumber evidence="19">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">AFUB_015530</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="19"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNL0"/>
    <dbReference type="Allergome" id="79">
        <property type="allergen name" value="Asp f 9"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015530"/>
    <dbReference type="HOGENOM" id="CLU_027506_3_2_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="PhylomeDB" id="B0XNL0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000162">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760011" description="Crh-like protein" evidence="23">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="24">
        <location>
            <begin position="45"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="271"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="272"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="20">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="20">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP56832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="395" mass="40270" checksum="3640DC827F750008" modified="2008-04-08" version="1">MYFKYTAAALAAVLPLCSAQTWSKCNPLEKTCPPNKGLAASTYTADFTSASALDQWEVTAGKVPVGPQGAEFTVAKQGDAPTIDTDFYFFFGKAEVVMKAAPGTGVVSSIVLESDDLDEVDWEVLGGDTTQVQTNYFGKGDTTTYDRGTYVPVATPQETFHTYTIDWTKDAVTWSIDGAVVRTLTYNDAKGGTRFPQTPMRLRLGSWAGGDPSNPKGTIEWAGGLTDYSAGPYTMYVKSVRIENANPAESYTYSDNSGSWQSIKFDGSVDISSSSSVTSSTTSTASSASSTSSKTPSTSTLATSTKATPTPSGTSSGSNSSSSAEPTTTGGSGSSNTGSGSGSGSGSGSSSSTGSSTSAGASATPELSQGAAGSIKGSVTACALVFGAVAAVLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNP4</accession>
    <name>B0XNP4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_005000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNP4"/>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="PhylomeDB" id="B0XNP4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="232" mass="27762" checksum="789A3A67098CF1BC" modified="2008-04-08" version="1">MGALKYVEEIQKKKQSDVIRFLLRVRCWEIANFVTNLAFLSRRRMMWMWHTRQVIFGLLRQLNAIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPVPKGATYGKPTNMGVNQLKYQRALRATAEERVGRRCANLRVLNSYWINQDSTYKYYEVILVDPQHKAIRRDPRINWICNAVHKHRESRGLTATGKKSRGINKGHRYNNTRAGRRHTWKIHNTQSYWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNW9</accession>
    <name>B0XNW9_ASPFC</name>
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        <recommendedName>
            <fullName evidence="2">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_015950</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_004682_1_0_1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        </location>
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        <location>
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            <end position="45"/>
        </location>
    </feature>
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            <end position="70"/>
        </location>
    </feature>
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        <location>
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            <end position="88"/>
        </location>
    </feature>
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            <end position="101"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
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        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="948" mass="104588" checksum="B657F2631313A854" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNY7</accession>
    <name>B0XNY7_ASPFC</name>
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        <submittedName>
            <fullName evidence="7">PHD finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_016130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_020023_0_0_1"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <begin position="696"/>
            <end position="745"/>
        </location>
    </feature>
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        <location>
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            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="775"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="775" mass="84100" checksum="057C3247B4CB5DA4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP03</accession>
    <name>B0XP03_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GARP complex subunit Vps53, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_005450</name>
    </gene>
    <organism evidence="11 12">
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        <name type="synonym">Neosartorya fumigata</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005450"/>
    <dbReference type="HOGENOM" id="CLU_007339_1_0_1"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="PhylomeDB" id="B0XP03"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.110:FF:000003">
        <property type="entry name" value="Putative GARP complex subunit Vps53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="10">
        <location>
            <begin position="624"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="789"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="84"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="854" mass="94773" checksum="97C27FECCC8A04BC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP61</accession>
    <name>B0XP61_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_006050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006050"/>
    <dbReference type="HOGENOM" id="CLU_041826_0_0_1"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="PhylomeDB" id="B0XP61"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="344" mass="37881" checksum="37949D734EE289B1" modified="2008-04-08" version="1">MPTVLLPSSAAAFAPRSSPNVVLSAKIEPWLTATLKRVNRVKRPLNNVTQHTRCLTETLSSPNAIWTLCSMMFPKAPDSELRKDENPLVEAIFNYQMIHIEAYVVHVDMVSQNEVAFKLTPETIEALVEFHQDVYSVDAAASTWEWSEKRQQLKKLQEEFVQAANRFVYRTNVQALEGLEEDGAGELLGGRSDEAKAAIESLFVPLRPPPPRVVDVLRSTPILPSSVGMDTWWQPPMQQPASMETWKVLPSSPTTASTGDSNPNLWASLSGLDETHYPSSTSSYSQSFTTSPYDSGPYYNAAVTSAAMTALPLPSMLVQPCGTAASVSGFSWGGRYQDFALMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP65</accession>
    <name>B0XP65_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_006090</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006090"/>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="PhylomeDB" id="B0XP65"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000008">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP55908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="58934" checksum="4CD089566349EAF3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPJ9</accession>
    <name>B0XPJ9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_006740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006740"/>
    <dbReference type="HOGENOM" id="CLU_048908_1_0_1"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="PhylomeDB" id="B0XPJ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="68"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="343" mass="38298" checksum="BF3691031EA91984" modified="2008-04-08" version="1">MPLVRKRRAEQQLESDNDDEVSTQVAGLVSTENARRRLRRTSDSENDDDAGPDDARAPSSEDVMVKKLVRLALASELSRQPIRRTDISTKVLGEQGSRQFKIVFEMAQKTLRETFGMQLAELPVKEKVTIQQRRAAQKVDRPSSTNKSWILTSTLPLAYRKPEILPPTRAPLEGTYTGLYSFIIAVILLNGGSLPEQKLERYLKRTNADTYTPVDRTDRFLQRLCKEGYLIRNREMEGGEEIIEYMVGPRGKVEVGVRGVAGLVREVYGRQGIVEGNDSTPAERAQMEEFESRLARSLGIRRPEARVADDQDGSGDGEGSEAGRGRRRRGGGSDDEADDDSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPS3</accession>
    <name>B0XPS3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_007390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007390"/>
    <dbReference type="HOGENOM" id="CLU_038278_1_0_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="B0XPS3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000073">
        <property type="entry name" value="C-type cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000101">
        <property type="entry name" value="Cyclin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="438" mass="50337" checksum="2760FC95C3FA8E36" modified="2008-04-08" version="1">MRGQRFSRIHHASSWVLVHLPIYPSLPGKTRRFFRQHHRMTSEKKDDTTQPAGAEPSLPEPPAIHPSFIQVAKPYIFEQTIQKCIAAMGVNPLREEALRLQGVTWIDNVRRVLYLPIRTFNTAVVYYHKFRLIHPDTEYNYMDAAAAALFTACKIEDTLKKSREIVCAAYNLKLPPSEHMSPDNPVFEAHARGIIGLERLMLEASGFDFRTRHPQRTLIKLARHYGLSPQSEVSNLAYRISQDLYRTFAPIKQTTSTMAFCSLELAGRLLDQRLEPVEQGSDYEQWRTSREEVMETLFDLLELYTHNRNSTTVGPHFPPDRFLTVRIPLNKEAEAQRLPRYTHWVEDSRDSKPTDGARDGKDRPALKKRERDRDREAAAAPAVHPLTPVAANGERPKAGERGRDGAVRFMLDSECAKAEKARVAEYFKIEMEEYEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPU2</accession>
    <name>B0XPU2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phosphofructo-2-kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_007580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007580"/>
    <dbReference type="HOGENOM" id="CLU_006383_3_1_1"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="PhylomeDB" id="B0XPU2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="130"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="292"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="708" mass="79250" checksum="FEDB0E689020773F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPV5</accession>
    <name>B0XPV5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_007710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007710"/>
    <dbReference type="HOGENOM" id="CLU_074897_1_0_1"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25348" checksum="5B7C8C1BFB31AA04" modified="2008-04-08" version="1">MGWLWRSSPSKEEPQQISSVPSFSDNAAPQPSPAAEAPGTMPSSSQSRPLSRKEQADAEFNQLLESLKADVSRTKSPQQSSNVSETPLSPSSPSPSGPPQPPSSIAPESLYPDSMSCRSAFDYAFFCQSFGGQFVNVYRYGELRSCSEHWDNFWLCMKARGMADEERKKVIRDHYRKKAIKYKTGPSSEDVWDLRREPVQHAFQGDFEALEREMKAEEEASRNAGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ43</accession>
    <name>B0XQ43_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA family ATPase/60S ribosome export protein Rix7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_008630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008630"/>
    <dbReference type="HOGENOM" id="CLU_000688_8_3_1"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ43"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000081">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000149">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein Rix7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="253"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="557"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="784" mass="86526" checksum="731C76917CBD4EF7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ86</accession>
    <name>B0XQ86_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-interacting protein (Bud6/Aip3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_009090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ86"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009090"/>
    <dbReference type="HOGENOM" id="CLU_005287_0_0_1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ86"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="508"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="955"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1055" mass="114729" checksum="BC775DBC3A07F680" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQI1</accession>
    <name>B0XQI1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_010040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="B0XQI1"/>
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    <dbReference type="HOGENOM" id="CLU_006240_2_0_1"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="PhylomeDB" id="B0XQI1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2130:FF:000001">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="933" mass="101743" checksum="FF65F8CE908DAA07" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQU9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_011230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011230"/>
    <dbReference type="HOGENOM" id="CLU_036838_9_0_1"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="PhylomeDB" id="B0XQU9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.245.10:FF:000006">
        <property type="entry name" value="Inosine-uridine preferring nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="100"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="522" mass="58425" checksum="5E947597AB2AA958" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQX9</accession>
    <name>B0XQX9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_011540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011540"/>
    <dbReference type="HOGENOM" id="CLU_097408_1_2_1"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="PhylomeDB" id="B0XQX9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="175" mass="18627" checksum="6A12BC299CD8ADB6" modified="2008-04-08" version="1">MSSVARSLRPFASRVLSQKAPLTSSVRRASPALCFPRGSIRSFTQSPFLEVKKYTESHEWIELGEDGKTAKIGITEYAAKSLGDVVFVELPDADLEVSAGEAVGAVESVKSASDVLSPVSGKVVQGNSVLEDNAKFINQSPEGDAWIAKIEVSDVAELDGLLDEAAYKASIDADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRP7</accession>
    <name>B0XRP7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SUN domain protein (Adg3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_013430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013430"/>
    <dbReference type="HOGENOM" id="CLU_026108_1_1_1"/>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="PhylomeDB" id="B0XRP7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757809" evidence="3">
        <location>
            <begin position="22"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="329"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="470" mass="48663" checksum="8D155777760F529A" modified="2008-04-08" version="1">MRFDMISGASALLWFVASVEASKHAHRHQMRNEHSAVHSVAEVGAPLEKRGGKCQFPTDAGLVAVTPNMKNAGWAMSPDQACEPGNYCPYACPPGQVSMQWDPEATSYSYPKSMNGGLYCDKNGQIKKPFPDKPYCQDGTGAVGAKNKCSKQVAICQTVLPGNEAMLIPTLVEDTATLAVPDLSYWCETAAHFYINPPGYDTETACVWGTSAKPIGNWSPYVAGANTDGDGNTFVKIGWNPIYLEPTTPFRDVVPDFGIEIECEGDGCNGLPCKIDPAVNAVNEMIGSTSVGAGGATFCVVTVPKGEKANVVVFEKSGGSSGGDDDSHSTTAAPSKPSSTTRTTSSSIESSSTSTSASSSSSKPTDTDSSSSSATVTPSASSDPSSSAKASSAGQASESGTFSYTYKPHVFVEQSVSVQAMADETAGPAQATATPTPASKEKEKEGSAADVAVSVLTLGMGAVAAIMINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRR3</accession>
    <name>B0XRR3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF788 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_024550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024550"/>
    <dbReference type="HOGENOM" id="CLU_993871_0_0_1"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="PhylomeDB" id="B0XRR3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31563" checksum="4F4530333FED19B6" modified="2008-04-08" version="1">MTSRTRDALQAKQEPPREIKKAYREMKTGLELSMTSEKRAANGFKKQEEQRRRAVKSIDRVRLDPSPGRAFFGACGCFGATEYNRLGKVAGADRGAGACLVVVGNRQCRFYFTPKAAKTLAARNASLLLRTHIIALCLHSIFLLLHWTFNRPRSLKPYFFLACPTLAIEFYLERLGRPSYNPADGSLRSPGEDLGASGLTEYMWDVLYWTWGCMGAACLFGDRAWWLWIVIPIYSVWLAYTTFTGMKSGLAGMGGADTPVAESKRQKKMEKRGGQRMQYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRY3</accession>
    <name>CUTI1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable cutinase 1</fullName>
            <ecNumber evidence="5 6">3.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cutin hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_025250</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (By similarity). Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="5 6"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRY3"/>
    <dbReference type="SMR" id="B0XRY3"/>
    <dbReference type="ESTHER" id="aspfu-q4x1n0">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP54469">
        <property type="protein sequence ID" value="EDP54469"/>
        <property type="gene ID" value="AFUB_025250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025250"/>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="PhylomeDB" id="B0XRY3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395251" description="Probable cutinase 1">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P11373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P52956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="211" mass="21856" checksum="43B8A1C7C8956014" modified="2008-04-08" version="1" precursor="true">MKFALLSLAAMAVASPVAIDVRQTAITGDELRTGPCEPITFIFARGSTEPGLLGITTGPGVCNALKLSRPGQVACQGVGPAYIADLASNFLPQGTSQVAIDEAAGLFKLAASKCPDTKIVAGGYSQGAAVMHGAIRNLPSNVQNMIKGVVLFGDTRNKQDGGRIPNFPTDRTKIYCAFGDLVCDGTLIITPAHLSYGDDVPSATSFLLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRZ3</accession>
    <name>B0XRZ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor subunit eIF-4F, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_025360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
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                <person name="Venter J.C."/>
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                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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            <dbReference type="SMART" id="SM00543"/>
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</entry>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
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                <person name="Venter J.C."/>
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                <person name="Whitty B.R."/>
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        <source>
            <dbReference type="EMBL" id="EDP54587.1"/>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Joardar V.S."/>
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                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
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                <person name="Orvis J."/>
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                <person name="Sundaram J.P."/>
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                <person name="Wortman J.R."/>
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            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    <dbReference type="HOGENOM" id="CLU_006462_2_3_1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="PhylomeDB" id="B0XSJ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="42"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="604" mass="70316" checksum="BF92A78CD8DC800E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XST6</accession>
    <name>B0XST6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase, family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_017550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XST6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017550"/>
    <dbReference type="HOGENOM" id="CLU_1081739_0_0_1"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="PhylomeDB" id="B0XST6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758307" evidence="3">
        <location>
            <begin position="19"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="4">
        <location>
            <begin position="103"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="257" mass="29248" checksum="986F43E1858EA75F" modified="2008-04-08" version="1">MFVKRWLLSLCAVSTVWANPIQTREADYVMPSPAGFRMQHGFETLHLRQGFEDGKAHGLESDTRFNGNRTVVIRNGKIPMVGNGCGRVPGCPDGAVELQHRHAEYRELYVRWLQWATLLPFMRTLGSRKCNVQNAHTCNNEGWSYGEENTPMIVSYIQLRYQLKAYLQALFEQIHHTYDAAVTCLACGCLSSGDDTQCTEWEVYLPQKGQSETKPWTYRWTNETYAGGLTVTVPAPIEHVPLFYLGKREDIMSGCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSY2</accession>
    <name>B0XSY2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_028200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028200"/>
    <dbReference type="HOGENOM" id="CLU_053549_1_0_1"/>
    <dbReference type="OrthoDB" id="5407781at2759"/>
    <dbReference type="PhylomeDB" id="B0XSY2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010890">
        <property type="entry name" value="PriC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07445">
        <property type="entry name" value="PriC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="345" mass="36492" checksum="1373E89B1E8AC9B3" modified="2008-04-08" version="1">MPPDLNSLPPSRSPSSPRPPRTAPASSESVSVVSPAASSTTMNNNSNATDLSRRSSRASPRTRLSISEHRRPPTGTNSNLSESEIPPAEHRSSLSHALRTSSPTIGGSPVIATGDPHHQRAPSLGELHQELEQEQEAQVNRLLQMIRSQQAQLQQLQQQQQQQQSGAAVEDSTPPSERSAGVPIIPPLPAAGSGRTSTQFPSSLSSHRASRPSSQTASPSLRPLPSASLHGTSVDSSRGPEGLDLVASTSETSSRRGSRDEVAFYQAEASMLNRENQMLRQRIRELGLSAVFPPSVICAKSRHLGLTTSGARPEQNVPPATQGTETADQHASAGVGPATEPTNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTA8</accession>
    <name>B0XTA8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meiosis induction protein kinase (Ime2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_028770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTA8"/>
    <dbReference type="HOGENOM" id="CLU_011172_0_0_1"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="PhylomeDB" id="B0XTA8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="695"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="784" mass="85965" checksum="C583146556696017" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTR7</accession>
    <name>B0XTR7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_029690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTR7"/>
    <dbReference type="HOGENOM" id="CLU_075862_0_0_1"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="PhylomeDB" id="B0XTR7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28225" checksum="0E87B32CCB4E933E" modified="2008-04-08" version="1">MDTTSEPPAFNLTDTDREVLAMTDDQFVPHDWDNLKDIIGMRSRPYLFAFSPHTARNDLGALKRKPSDLVRYLSWSRDTKAQYGSITNFICKRRLGWHLPEPAGTDDSSGTAVADSEPVFPYNNPIPFADPSDYKILRNDWPYGLAPGIAHLCVWLRTPVPVQEHGGDLTDESRRLIEEFVRRTFVERLAREGYNNPKDHVLWFKNWTALQSVRSLEHIHVLIRDVPESILFEWTQEPPRDGLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTX5</accession>
    <name>B0XTX5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exosome complex exonuclease Rrp40, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_019430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019430"/>
    <dbReference type="HOGENOM" id="CLU_069847_0_0_1"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="PhylomeDB" id="B0XTX5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000091">
        <property type="entry name" value="Putative exosome complex exonuclease Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="168"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="274" mass="28991" checksum="93D15C664AA61FCF" modified="2008-04-08" version="1">MSSPVILLPGDHVPSDKLPSNKSAPLRLGPGLRLLSPAIPSPSSGHVIASTQAGLLSTDYKKNAVSVLSFPNRRYIPTPNDLVIAQVHHSSAEYFYCMITPQSPHVLLGQLAFEGATKKTRPMLRQGDLVYARVLSIGLGAGAEVELTCVNPATGKAEPGGLGPLNGGMVFDVSTGMAARLMRASSSTSEQEDGVDGLVVLEELGRKLEKVGGFEIAVGRNGKVWVDCSNGGDAAVKATVAIGRCLTAIDEHDLNQTDQRKLVTRILREMKVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU53</accession>
    <name>B0XU53_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinesin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_030370</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030370"/>
    <dbReference type="HOGENOM" id="CLU_001485_20_0_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="B0XU53"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000357">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="8"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1513"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="610"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="780"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1632" mass="182726" checksum="1CAED6825E77444D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU89</accession>
    <name>B0XU89_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_019890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019890"/>
    <dbReference type="HOGENOM" id="CLU_2196341_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="108" mass="11731" checksum="93011A59A5D06BEF" modified="2008-04-08" version="1">MRTRNFSSMPSGAFIAVPSAFGIRTYVALDILLASGGVSLFAVEAFPAVVGLYQHVLRTHNLIPLLELCDGITGLNNNTGEFMAHDKSRARRLNATVRMKVATTPRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUC3</accession>
    <name>B0XUC3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_020230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020230"/>
    <dbReference type="HOGENOM" id="CLU_085417_0_0_1"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="PhylomeDB" id="B0XUC3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="205" mass="22718" checksum="72912CACC1A7CB47" modified="2008-04-08" version="1">MDTDSPTETRSTEPSTLLKILHWDKLFESDTPPRLGIEVGKRLPFTALSAFSVGMAIGSSHGSKKAAYRFRAENAHRFPTTSTGWFQYHKTKNYIAIVGGVKEGMKMGFKLSAGALAFCIFEETVDYARHDRRDFLSTVTAGLSFSGIYSLLARHDVYTAARTTKLGLKLSMAYGLMQDALETLKGNRPAYVDFILGNRVSKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUQ3</accession>
    <name>B0XUQ3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_020880</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUQ3"/>
    <dbReference type="SMR" id="B0XUQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020880"/>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="PhylomeDB" id="B0XUQ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="60"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="447"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="487" mass="54344" checksum="0C8257E689AE6EBC" modified="2008-04-08" version="1">MARSAIVQEYNPPPPSNPTLSVDRKVSLERQKNGIPRPQGYRVSWHANPAVEPHHFGQSHPMKPWRLTLTKQLVMAYGMHHAMDLYLARAATYEEMAEFHQTDYLDFLRQVMPGDMENPEQSENIARFNFGDDCPIFNGLYNYCSLYAGGSIDAARKLCNNQSEIAVNWSGGLHHAKKAEASGFCYVNDIVLGILQLLRHHPRVMYIDIDVHHGDGVEQAFWSTDRVLTVSFHKYDKDNFFPGTGPLDSTGPTHPLNPGAHHAVNVPLNDGIDDESYIQLFRDIVGACVDTYRPGAIVLQCGADSLGCDRLGCFNLNVGAHGACVAFVKTFGLPLLVVGGGGYTPRNVSRAWAHETSILIDAQDLIDPNIPDTVAFRNHFGPDYSLFPPLSEMRKLENKNSRPYLAGLVQSVREQLRYIQGAPSVQMSFIPPDILGLREDTEKEIEEATARLEEEREEREGPGSAAVKSNRRRELERGAGYRGELYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVK4</accession>
    <name>B0XVK4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cell division control protein (Cdc5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_022560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
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                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
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                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
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                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
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                <person name="Sundaram J.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
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                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
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                <person name="Orvis J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024080"/>
    <dbReference type="HOGENOM" id="CLU_007127_10_0_1"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="PhylomeDB" id="B0XWA0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000010">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="877" mass="98489" checksum="62273C11CFF878E7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX22</accession>
    <name>B0XX22_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_047450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047450"/>
    <dbReference type="HOGENOM" id="CLU_1372552_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="B0XX22"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="242" mass="27110" checksum="A9EEDB3911387212" modified="2008-04-08" version="1">MSPVVPSLLSSQYSHLLVRHRTPNQPGDNPTKLISQRPSPTITMQFRFKERLSYQGNPQELETFMKRKLERSTSAQESPKPEDPEKQTRQERTALHDAAEFGYPNFALTFIEQGNDINAVDAKGRAPLHVAVQAGQEEVANLLIKKGADVNVHDNDGLTPLHFAVVLRSVALARLLVQAGAHPRAENAHGHTPFLFAYLFEEDEILECFAETSRPKAEAVPSSTLRGYLVNMRSWAKMRSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXI6</accession>
    <name>B0XXI6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_048460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048460"/>
    <dbReference type="HOGENOM" id="CLU_2108494_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="115" mass="13192" checksum="823DB3F7CDCAD679" modified="2008-04-08" version="1">MAQKIKTHQSHVKSPETENDEVVKLWKDETKQGMFTYILPKTHLPLLFMYSAKGEQCLYMRQMEVIMSTVLERRIRKVPSSFLGTINGGCKNGARFAMLFVSSEVGTLDHKWLGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXN8</accession>
    <name>BCK1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitogen-activated protein kinase kinae kinase bck1</fullName>
            <shortName evidence="5">MAPKKK bck1</shortName>
            <ecNumber evidence="7">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bck1</name>
        <name type="ORF">AFUB_038060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="909" last="918">
            <title>The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Valiante V."/>
                <person name="Jain R."/>
                <person name="Heinekamp T."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="19715768"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2009.08.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Mitogen-activated kinase kinase kinase (MAPKKK), part of the cell wall integrity (CWI) signaling pathway composed by three protein kinases bck1, mkk2 and mpkA and responsible for the maintaining of cell-wall integrity balance (PubMed:19715768). The CWI pathway also regulates the oxidative stress response, as well as the production of some secondary metabolites including pyomelanin (PubMed:19715768).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to the formation of thicker hyphae, which appear less elongated and form more branched hyphae (PubMed:19715768). Results in increased sensitivity to cell wall integrity inhibitors such as glucanex, SDS, congo red and calcofluor white (PubMed:19715768). Impairs phosphorylation of the MAPK mpkA (PubMed:19715768).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="7"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0XXN8"/>
    <dbReference type="EnsemblFungi" id="EDP52640">
        <property type="protein sequence ID" value="EDP52640"/>
        <property type="gene ID" value="AFUB_038060"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038060"/>
    <dbReference type="HOGENOM" id="CLU_000961_3_0_1"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="PhylomeDB" id="B0XXN8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000454886" description="Mitogen-activated protein kinase kinae kinase bck1">
        <location>
            <begin position="1"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="739"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="832"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1164"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="871"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="956"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1199"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="1453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="19715768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="19715768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="19715768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1617" mass="175919" checksum="1AB12BFE38D84FBE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXZ3</accession>
    <name>B0XXZ3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroneopterin aldolase</fullName>
            <ecNumber evidence="4">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_039080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039080"/>
    <dbReference type="HOGENOM" id="CLU_062068_1_0_1"/>
    <dbReference type="OrthoDB" id="5425486at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000011">
        <property type="entry name" value="Dihydroneopterin aldolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000013">
        <property type="entry name" value="Dihydroneopterin aldolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="8">
        <location>
            <begin position="229"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP52739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="351" mass="38644" checksum="78044E82B4A778EE" modified="2008-04-08" version="1">MAEQRVNVHIPSHPAVLDSVQLRNIQLPLPVAPDPWHRDGKPQPCTASLKLSYSSAIAAAAADDVSLSLDYGKLYRRLEEDIRNMGKHSLSPSQRMVSADGSRRDEMMRTEIGQDVRLTAGIVANCGLGLLDETAAGIRRMSHVHCHPGSRRGSASAEIQAPLAGLSLASPPIDSVYGQCEVWLQLPKALLRAEEGLKYRSVTVWGYRQGDESTALDGERCPVVLEEEFRIDGIRCHCILGVNSHERVEKQAVIISLEFKGPGQLAWGSTVVDTYQEMTRRVAEQVEETAFQTVEALATFVARIVTVQFANERVTVRVEKPSALSFVERSGIEITRSQAFFEKSDLEGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYB1</accession>
    <name>B0XYB1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_040280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYB1"/>
    <dbReference type="SMR" id="B0XYB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040280"/>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="PhylomeDB" id="B0XYB1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000106">
        <property type="entry name" value="Glycosyl hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000052">
        <property type="entry name" value="Uncharacterized glycosyl hydrolase YIR007W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="638"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="759" mass="86064" checksum="5CE99981A49DB31C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYC0</accession>
    <name>B0XYC0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endosome-associated ubiquitin isopeptidase (AmsH), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_040370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYC0"/>
    <dbReference type="MEROPS" id="M67.A14"/>
    <dbReference type="HOGENOM" id="CLU_023304_4_0_1"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="PhylomeDB" id="B0XYC0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000024">
        <property type="entry name" value="Endosome-associated ubiquitin isopeptidase (AmsH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="352"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="532" mass="59317" checksum="F41C86A23877398E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYX0</accession>
    <name>B0XYX0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Octanoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_042370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="5"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042370"/>
    <dbReference type="HOGENOM" id="CLU_035168_0_0_1"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="PhylomeDB" id="B0XYX0"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000108">
        <property type="entry name" value="Octanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="53"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP53066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="306" mass="32915" checksum="212CD6377BFBB5F0" modified="2008-04-08" version="1">MKLAHLHFPDITSFTRVAHLQQILTNRLLAYKRLSSPATANTGAIQPSGVNSPPPDPTIITFTPNPVYTTGRRDLPPSNTAPFSPSAPLSLPPSLEPIRSILTAPPNGSPRAEYHPTLRGGQTTYHGPGQMVAYTILDLRRLGLTPRCHIRLLENSVIDVLRGYGIQGFVTEDPGVWVRPRPATNTAAAMAVSAGGDGDADGVLPKKITAVGVHLRRNISSYGIGFNVTEEPMWYFQQIVPCGLEGREATSLEGEGVPGVSTGEVADKFVDAFVQRVNADFACGGRATGEKIEGVYNVREEDLLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ36</accession>
    <name>B0XZ36_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_043020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043020"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ36"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP53132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="147" mass="16522" checksum="9DDFACBEE446CD05" modified="2008-04-08" version="1">MALKRINKELTDLGRDPPSSCSAGPVGDDLFHWQATIMGPGDSPYSGGVFFLTIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRPRYEATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ42</accession>
    <name>B0XZ42_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_043080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043080"/>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ42"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="218"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="690" mass="75004" checksum="BA0DC2DC8041E79B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZJ5</accession>
    <name>B0XZJ5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_034090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034090"/>
    <dbReference type="HOGENOM" id="CLU_1602309_0_0_1"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="PhylomeDB" id="B0XZJ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18815" checksum="93232A9E0FFB8C2F" modified="2008-04-08" version="1">MWSGTGAALTGGPWRVPTDRMWAVDIEPGLWRLGFELFRGRGRMKARFIQGDFLSMADDSLGELQGNVDVVIASQFPHQFSRDGQTMATKRIVALSQPGTMLVGYQQGRKTAREYMRPWGMMFYHNLMSFVQLWDGVQQETNTQWRLEVTEIARGSTLLLLASHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y043</accession>
    <name>B0Y043_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_045570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y043"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045570"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="PhylomeDB" id="B0Y043"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="43"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="409" mass="43564" checksum="0250E9DD441CD84C" modified="2008-04-08" version="1">MSIKLRSSSAASIVLLVSSIPPMPLSIAMTPKNQAAWIPAKKARPFKVGDAPYTPAGPGQVVVRNTAVAINPFDWVLQFIGPAIASYIKYPFIFGTDVAGEVVEVGPDVERFRVGDRVFGSATAIAKEVNRPAEGGFQLYTVMRQHMLAPTPAHITDEQACVLGLGLLTAAWGLFHPNYLGLDMPQVPAPTGAVGKSGLPRAVIITGGASSVGSNAVQLAVSAGYQVLSTSSPKNFEYVKGLGATQVFDYRSRTLSKDLLAALRGHELVGALTIGRGAVEACTAVMKHHDVRLTRKRIAVAGAIIPAEKLTTFVGKGTYLMGMVGGMIKSNARRRRTGVEAKFILLDGLVDPESIVARIYREFLPLALERHQFVPAPPTHVVGKGLNKIQDALELQRMGVSGKKLVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0J0</accession>
    <name>B0Y0J0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_046370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0J0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046370"/>
    <dbReference type="HOGENOM" id="CLU_979944_0_0_1"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0J0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30889" checksum="79614DB847B838F8" modified="2008-04-08" version="1">MAHGGQTSLHAATSANPIKTVSLLIKHGGNVNVIDPWPESALHLSLSDWIEAEIWKITPSQTKMVKRRNTIRLTPLTYAARNHHLQVVLLLLRHTEGVDFADESLRPAVTSAVAFSDVVFLELVIEKGKLSDSIRTNAMDETPQHCAAINGSRSAVRLLLEKGVNVELHDKSALVPLLLEASKGHTAVVCLLLEYSASIDPTNADGDTALMIAVHNGHHETILSLLARSVAIDCVNHAHRTALSRAAENDHDKIVEILLQYGTEVDLPNHTGQTPLTLSDTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0K2</accession>
    <name>B0Y0K2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular serine-threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_057610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057610"/>
    <dbReference type="HOGENOM" id="CLU_065618_2_1_1"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760613" evidence="3">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="267" mass="26606" checksum="5D0FCFB328856975" modified="2008-04-08" version="1">MRLSIASVVSCLAALAMAATKPDYTQDPTGNAILKPGLNELVPAGKPYTITWDPTTTGPVSLVLLRGPSTNVVPIETLADSIPNSGSFSWTPSTSLEPDTTHYGLLLVVEGTGQYQYSTQFGISNPGYTGSTSQSSSTSPTATETKSSSATESSSSKSSTTGKPETTTTTTPPTTTATSGSASADSTTTASETPATTLVTQSSTANVPTSTVVVSVPNSSAGSSSGASGSPSQSSTPSPSPTLSSGGDRKAISLGAVVVGAFAVMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0L7</accession>
    <name>B0Y0L7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_057760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057760"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0L7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000528">
        <property type="entry name" value="Nucleoside-diphosphate-sugar epimerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="305" mass="34481" checksum="C2D718A48BEE83BA" modified="2008-04-08" version="1">MKSILVTGATGKQGGAVVNALLAEDADIEILAVTRNPQSSAARNLADKSPKIKVVQGNLDDPAGIFKNAHQVSSEPVWGVFSVQLPMGQGQTVEKEERQGKALIDEALTQKVQHFVYTSVDRGGDASTDNATNIPHFISKHRIEHHLFEQTHGTQMSWTVLRPVFFFDNITRDFIGRLVVTAWDAYLQGKPLQCIAVSDIGYFAAQAFLNPAEYRNRCLSLAGDVLTYEHMQETMKRKTGREAPTTFRLVCYAVLWIVKDLRTMFEWLYAHGYRADIPRLREMHPGLKDFERWLEEDSQFVNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1F3</accession>
    <name>B0Y1F3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_060130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1F3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060130"/>
    <dbReference type="HOGENOM" id="CLU_039329_4_0_1"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1F3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="49"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="426" mass="47077" checksum="359FE9E283F04101" modified="2008-04-08" version="1">MIIHKSQKSIANRFFSVVTFTNHLCYNLLRQAYWSPESKEKKMSSPLIVDIHTHVYPPAYMELLRSRKVVPYVHDPVSATPRLVILSSDDDPSIPLDERGRPVDSSYWNINVKLAFMRRHGINCSVISLANPWLDFLEPDEAQTWAERINDDLEQTCARVNQAADPDKTHSLHEKETLFAFGALPLSAPRADIVVNEIKRLKTLPHLRGVIMGTSGLGKGLDDPALDPVWGALQETETLLFLHPHYGLPDEAFGGPEVINRYGHVLPLALGFPLETTIAVARMLLSGVFDRFPRLKILLAHSGGTLPFLAGRIESCIHHERKFVANGGNVSGPQRSVWDVLQTNIYLDAVVYGTAGLKAAVTAAGGADRLMFGTDHPFFPPLDTNEDAEWPSVTTNYKAIHAAFDTEKEAVGAILGGNAGRILNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1S0</accession>
    <name>B0Y1S0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="13">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_060630</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1S0"/>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1S0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="43"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP52029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="122" mass="13851" checksum="855AEAD4181CEC07" modified="2008-04-08" version="1">MSTDPKIQCTVSLNRDLLNKPKSELTEYEVALVEEHELTAGPLSLLQTATRTHTQVLISCRNNRKLLARVKAFDRHCNMVLENVKEMWTEKPKGGKGRGVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y272</accession>
    <name>B0Y272_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_061500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y272"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061500"/>
    <dbReference type="HOGENOM" id="CLU_058062_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="40461" checksum="2C306E2C19F98239" modified="2008-04-08" version="1">MTTLPESKMSTTRYTMWYWYDQSCAFKTEDPNFSLNQLSKLVNAVQKEVNDETLVLPSQGPARPRQMEVAVFFPTSDADQGRFSCETGTELINRKARELKLPCSDFVSQSVENVRSFTRQEIERVFSFAKLPPNLIKEASEKIPSGQSHSVYIAKSAASIGAVYESGSAIVALICIGVNYGALTAGSIMTLIAPWVAGALLLIVNVMFVANDTDDAVSASAEDIANGERTTKTAYMPPATHAVTRGKDVVHDDNDMISVGVYVYSKKKVLGRNFSFFFGSLVGIPFRFTREGGQFSVGMDCPNSFFGGTNSVRVVPWYDPSGVAKRAMDSHTQSEELSVSPWKVSVHRSDNGPINWVFCHAGPTTYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2N7</accession>
    <name>B0Y2N7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_062470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2N7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062470"/>
    <dbReference type="HOGENOM" id="CLU_045401_1_2_1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2N7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00300">
        <property type="entry name" value="LDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="150"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="309" mass="32863" checksum="D4EEC0F923D4039A" modified="2008-04-08" version="1">MLSTDGPRIGIIGVGQVGAAAANALIMNSVARELILVDIKTELRNAQVQELSDVSRMSGRAETRVRAGTYHEAGQCDIILITAGSKFSVGETSVQHMYRNLGIVRSVIQAMRPFRSDAILIVVSNPVDLLTTLAQQLSGLPRSQVMGSGTLLDSVRLRGLLANKVGVAADAIDIYVLGVQGLDEIVAWSTASVHGLPLASAVPGNTFEPVQLTHECKQISQAIIKAKGAMPLGIGAIISMICLSILGDQRHVLPISHFQEEFGCCFSLPVVLGRKGILRTISMPVNGEEWDGIVKSAAALNETIEHVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2S4</accession>
    <name>B0Y2S4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_051800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2S4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051800"/>
    <dbReference type="HOGENOM" id="CLU_1916607_0_0_1"/>
    <dbReference type="OrthoDB" id="4498167at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="132" mass="14772" checksum="8F977C300E85D8C8" modified="2008-04-08" version="1">MQQPKDTDPNFPVDGGGCRPQGETHIETQRSVDPNMSIEDYNRVMLQYTQRRMSTFLDMGNDGGPPPSRNGRSSDSVATLSKRVFLYLLASDTRGIVETSHLRHNSLSPLKPLSEVDMAFLHGGFIQWFPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y338</accession>
    <name>B0Y338_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peroxisomal membrane protein Pmp47, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_052830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y338"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052830"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="PhylomeDB" id="B0Y338"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000134">
        <property type="entry name" value="Peroxisomal membrane protein PMP47B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="122"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="226"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="324" mass="35343" checksum="DCF78E583C800ED6" modified="2008-04-08" version="1">MSQSRIQEQKRAVAASAAAQQSDNIAHALAGAGGGILSMVLTYPLITLSTRAQVESKRAQSTTMDAVRRIVQREGFSGLYSGLESALFGISVTNFVYYYWFEWTRAAFEKAAVKAGRASKKLTTAESMIAGAIAGSATVLITNPIWVVNTRMTARKSDAEDQALPGAPEKKARASTIGTLMDLIRREGPTALFAGVLPALVLVINPILQYTIFEQLKNIVERRRRMTPKDAFYLGALGKILATTITYPYITVKSQMHVASKDGPKESLNGSLKRIISEEGYTGLYKGIVPKVTQSAITAAFLFAFKDVLYDMMVTARKRSRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y366</accession>
    <name>B0Y366_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_053110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y366"/>
    <dbReference type="SMR" id="B0Y366"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053110"/>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="PhylomeDB" id="B0Y366"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:dITP diphosphatase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP51307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="187" mass="20737" checksum="651BE0264D364EFC" modified="2008-04-08" version="1">MIPTVKLNFITSNKNKLAEVKAILGNVVEIDSQAIEVPEIQGSIEEIAKEKARRAAEEIGGPVLTEDTALGFRALKGLPGAYIKHFLSALGHDGLNKMLDSFEDRSAEAVCTFAFCRGPGEEPILFQGRTEGIIVRPRGPLNFGWDPIFEHNGMTYAEMDKEEKNRVSHRYKALAKLKQWLEDGTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3F8</accession>
    <name>B0Y3F8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_054050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3F8"/>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3F8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="60"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="167"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="281"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="468" mass="51574" checksum="9D29441A9C89076C" modified="2008-04-08" version="1">MSASTRIPPIAQPFVSDRAKRVLDLVRCLFTISPGYKFSNTCRGVQVEEFVEKDCIPAEAVFQAQLGEGEKRWQTNPAVLEELKAKARKLGLWNMFLPKNHFSQGAGFSNLEYGLMAEYLGKSKLASEATNNSAPDTGNMEVLAKYGNEAQKKQWLAPLLDGKIRSAFLMTEPDVASSDATNIELNIRREGNEYVLNGSKWWSSGAGDPRCAIYLVMGKSDPTNPDPYRQQSVILVPAGLPGITVHRMLTVYGYDDAPHGHGHISFNNVRVPVSNIVLGEGRGFEIIQGRLGPGRIHHAMRTIGAAEKALEWLIARVNDDRKKTFGKPLSAHGVILEWIAKSRIEIDAARLIVLNAAIKIDQGDAKSALKEIAQAKVLVPQTALTVIDRAVQAYGAAGVCQDTPLANLWAMIRTLRIADGPDEVHLQQLGRRENKSRQDAIVAKLKYQKEEAERLLLANGFQKPKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4A7</accession>
    <name>B0Y4A7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_057090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
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        <property type="protein sequence ID" value="EDP51698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057090"/>
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    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4A7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="364"/>
        </location>
    </feature>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51698.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="543" mass="59470" checksum="5296E079ED920B5E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4S5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">AFUB_070130</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000001699">
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="117" mass="12751" checksum="67812CF2F78F526E" modified="2008-04-08" version="1">MRISHLLFPHLLIGTGIWGTLLNHSHQPTGDQVGHIEALSDSSMAVCLLFVCFVFFASSAVFSLIVNRSNYSYIAFHHSLTALHCINGTPDRHPNSLRAILCSAVSLPIISDPPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y520</accession>
    <name>B0Y520_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">AFUB_071100</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y520"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071100"/>
    <dbReference type="HOGENOM" id="CLU_1008243_0_0_1"/>
    <dbReference type="OrthoDB" id="5150743at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="276" mass="32024" checksum="61D4A073A07B7636" modified="2008-04-08" version="1">MSYPSIRFHTGKDVSFGWRESCTALSAEMLQALLLESRLIVTTIETELRRRNQEPHQNSKLDICRRNLQKTANAIRVRKRLGERGVEQAKSLHGLFTGEQSDRFLKTYREFLEDVARQCGPESALLCHIGLGKHRVTNLKSEDRVNLLQILKDEYRSLSSDELKCLAESYHVRQLMESRPRSLPLIPQKRAWEETQIAAIPPVAGEREYCLFSFMRRSKIVELPEPFRSGMARSSLWKKEEERGGLAVTNCLSMYLPETALRGWVRDLEHIWSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5S3</accession>
    <name>B0Y5S3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_064400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5S3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064400"/>
    <dbReference type="HOGENOM" id="CLU_032651_0_0_1"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5S3"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000308">
        <property type="entry name" value="Cytidylyltransferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="9">
        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="289" mass="32581" checksum="1DFF9B411AAA4FF2" modified="2008-04-08" version="1">MASNSYKALRSQYQAALKRFIASSKNLEILNSVPLNHQQYQKQPSQAPDILYVLDSSFNPPTLAHLRIASSALLEKPSVPSRLLLLLATQNADKPSKPANFEDRLAMMELFAQDLLSHLGTISSSPADAGLQQIDIGVTKKPYFVDKAAKIEQSGIYPKALEQVHLTGYDTLIRIFNPKYYPPEHTLQRLGPFLSQHRLRVTMRPGDEWGSKEEQKAFLLHLAQGGREHEGGKREWAQRIQLVEGKKPGDKPVSSTKAREAIQTNSQDLDWLVPRSVREYILSQRLYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6L4</accession>
    <name>B0Y6L4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha and gamma adaptin binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_067370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067370"/>
    <dbReference type="HOGENOM" id="CLU_031716_1_1_1"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6L4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="48559" checksum="BF715719F9DE5D25" modified="2008-04-08" version="1">MFSAKKFPATNHIFSNPHGSKASNTKHLNPFEIDIKTLSDSRPAQAEPPSPEMTMTSSPDLNSASAPRIRNPRRLLILSPSSHSTSTIPSFLHSLTETPVADPPASFAGYTTHPLLRLTNRYYTADIPIWVDEIPLQTATDERTRTQTAGEGESAAPPSPAQWAVEFSGEDARVVRDAIGALVICIRNLEDRSASLPAGAGTGTDAGAGAGAGSPESRNDVKSLKEFLAAVGRVKGVIEEERAEVGDVPVLLVLVGGPRGHNGARVRGEEGDLEELDGESVEPFSVGWWEDQLFEMGMVGVEVLEWDPTGEEGEERNVYGEYQGMRRIREILETNDWAAPSEDAAPGGISGDGLEEHLLGLDCGENGFDLEVNELEREMLGLRMAIEHGGDGGEDQDEDEDNDDGLKVESLEALMMRMQAIRDMSSELPESERKKFAAKAVRDIMKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Q6</accession>
    <name>B0Y6Q6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle transport v-snare protein vti1homolog, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_067790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6Q6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067790"/>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6Q6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000002">
        <property type="entry name" value="Vesicle transport v-SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="224" mass="25635" checksum="B7A3ADD509648195" modified="2008-04-08" version="1">MSNPLDTDAGSELFSSYETELKLVQADLNQKLDQIAESSGEQRKSAIRMAERALDEANELLDQMRMEKQNIPSAARSKVNIRFRNYATDVDEAKRKLKSLSDDRKALFGDRYTDEPQDEHLEQRQQLLSGTERLERSSARLQESQRIALETEDIGRNTLADLYQQRQTIEHARAGLQQSEGYVDTSIKTLRGMARRMATNRIITIAIITVLVLLIFAVIYSKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6S5</accession>
    <name>B0Y6S5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_067970</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6S5"/>
    <dbReference type="HOGENOM" id="CLU_005327_1_2_1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6S5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="488"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="781"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="839"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="965"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP50460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116285" checksum="568A615617946893" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6U0</accession>
    <name>B0Y6U0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_068120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
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    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6U0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068120"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6U0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="103"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="550"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="670" mass="74528" checksum="183EB15DF356688F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y737</accession>
    <name>B0Y737_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_072440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y737"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072440"/>
    <dbReference type="HOGENOM" id="CLU_003963_1_0_1"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="PhylomeDB" id="B0Y737"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1209" mass="130663" checksum="2ADE15FCA9B296FD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y752</accession>
    <name>BGALC_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-galactosidase C</fullName>
            <ecNumber>3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Lactase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lacC</name>
        <name type="ORF">AFUB_072590</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y752"/>
    <dbReference type="SMR" id="B0Y752"/>
    <dbReference type="GlyCosmos" id="B0Y752">
        <property type="glycosylation" value="12 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP49233">
        <property type="protein sequence ID" value="EDP49233"/>
        <property type="gene ID" value="AFUB_072590"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072590"/>
    <dbReference type="HOGENOM" id="CLU_005732_2_1_1"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="B0Y752"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.390.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000144">
        <property type="entry name" value="Probable beta-galactosidase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395235" description="Probable beta-galactosidase C">
        <location>
            <begin position="24"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="719"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="758"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="804"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="257"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="983" mass="108035" checksum="61D896C6685A50A5" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7M5</accession>
    <name>B0Y7M5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sphingomyelinase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_074330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7M5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074330"/>
    <dbReference type="HOGENOM" id="CLU_034001_0_0_1"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7M5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052714">
        <property type="term" value="F:mannosyl-inositol phosphorylceramide phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP49406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="481" mass="53889" checksum="7BB8436825B7CC81" modified="2008-04-08" version="1">MDPSRSPSPSFSSPPSEIRILTLNCWGLKYLAKYRHERLSEIGRQLALADPPPQIVGLQECWTQQDYESIRQQTNHILPYGKFYFGGIFGAGLAILSKWPIEESTMYAYPLNGRPTAFFRGDWFVGKGVACARIRFGPEVGDVAEVFCTHLHAPYEREPNDSYICHRTAQAWEIAKLMRGAAERGHLVIGLGDFNMIPSSFAHQLIHAHAPVRDVWQVLHPDSSVGATIDLPEQKRNRPVPTAEFNLLENGATCDGRFNTWRWSKEDRKRLEKGEDVVVDKDSPCPRGKRLDYIFVGDGGYPPAYPAPRWSVQSVGVGMTQRHPTLRCSLSDHFAVEAVISRTASQATEPKEAVHPVSSAPNASCTPETYDHILGMIDKYVRRERSQRRWRLAHFVASVVVSIGCFVGVWWTGDHLPYVAFILCLVSTLSFGAGILDGLIGGLFVSSELRALKEFEWEVRNAKRIVERAGAQGTIKIEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7T9</accession>
    <name>B0Y7T9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI transamidase component Gpi16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_074970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7T9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074970"/>
    <dbReference type="HOGENOM" id="CLU_021459_2_1_1"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7T9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760499" evidence="3">
        <location>
            <begin position="23"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="600" mass="66676" checksum="298B62767E0AD56F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7Z9</accession>
    <name>B0Y7Z9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_075600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7Z9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075600"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7Z9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF31">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP49530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="284" mass="31546" checksum="252821FA322E230F" modified="2008-04-08" version="1">MADDNYVYTLYRYVPSIPAAAIMAAVFGLLAMGYLYRIVTHRTYFFVPFIIGLLFETAGYIARIFSHFDPNALGPYIVQTMLILVAPPLFAASIYMTLGRVILKLDAEPASLIRVRWLTKIFVAGDVISFLLQCGGGGYMAAGTLEAMKNGEHIVIAGLAIQLLWFGFFVVVASLFHWRVVRHPKYTISNDLRSQGSGISWSTLMWALYAACVLILVRSIFRVVEFVQGNAGFIMRHEYLLYVFDAVLMALTGIVLGLVFPGSFVSRRSRCADDAVPLGSQLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y836</accession>
    <name>B0Y836_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_075970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y836"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075970"/>
    <dbReference type="HOGENOM" id="CLU_008020_1_0_1"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="PhylomeDB" id="B0Y836"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF14">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760506" evidence="2">
        <location>
            <begin position="21"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="113"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="337"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="721" mass="78966" checksum="9B92552083C17ADF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8D9</accession>
    <name>B0Y8D9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking PGA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_077000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077000"/>
    <dbReference type="HOGENOM" id="CLU_121099_0_0_1"/>
    <dbReference type="OrthoDB" id="4227028at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="22278" checksum="CA0453ADE1634766" modified="2008-04-08" version="1">MATSESSSVVSDALNDFFSQLYTFIETVFRRFFKNLYRSFVEMSAKRWTKIIVIVVVYILIRPYIEAWFRKMAEKDRKKQLEKEKAEREAKRKNKAKISANALRGGATGGGKVLGEVENTDDEIESGEDFATASGVPEWGKNARKRQKKYMKELQREAEQRTEKLSDEQLLELLDWSESEDEKKQEETKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8I4</accession>
    <name>B0Y8I4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_077450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8I4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077450"/>
    <dbReference type="HOGENOM" id="CLU_054794_1_0_1"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8I4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF1">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="246" mass="27732" checksum="E50846292F916911" modified="2008-04-08" version="1">MGKFYPSITPDLHDWTLRQSVFFVASAPLRGKHINVSPKGLPNASFAILGPNEAAYIDATGSGSETICHLRENGRITVLFCSFDAAPRILRLFCSGSVIEWDQPEFGAYLERMGNKSVLGARAIIRLDVYKVQTSCGFGVPQLALKLDPETHEPKPYLKDRETLGHFVRKSVEKGQLRSYQREWNASSLDGLPGLWSAIRDDGGYVWVGRVRNWLRRHEDEIDVVKTSLLCFLLAMTVLRWMGYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8N6</accession>
    <name>B0Y8N6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_077980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8N6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077980"/>
    <dbReference type="HOGENOM" id="CLU_2498398_0_0_1"/>
    <dbReference type="OrthoDB" id="4255149at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="94" mass="10413" checksum="411750B600F5291E" modified="2008-04-08" version="1">MPKAYFDHDPITLQEGSHIGAVVGDKTIEPDGMEMVTGEVDRVIIRKSSDSTLELKCTQDVRFMPGEQVILQQLDPVSYAAIGMKSGKEVEFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8X6</accession>
    <name>B0Y8X6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_078900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8X6"/>
    <dbReference type="HOGENOM" id="CLU_1261226_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0Y8X6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="219" mass="25008" checksum="003BE28677042C2C" modified="2008-04-08" version="1">MERIIHPESTSAFDQRVTTFGKSSGIETPSGNNLGPFSKLFYASEAILKQQPLGPARVEKTEQLHEYIKQMEREKSELERHCSKLESECKRLQSVVLQQREGVLGSLRPKWFLKEDRTIQFELTKLQTTMRSWSREYSLADETEIEKVPAAEKNMVIKQLEGYCVQSDCVLVQAALAKTIFQGVFTDPFFFIDTRNNNMTGPGSPNMASIYETLMQSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9J1</accession>
    <name>B0Y9J1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_081229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9J1"/>
    <dbReference type="SMR" id="B0Y9J1"/>
    <dbReference type="HOGENOM" id="CLU_053879_7_0_1"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9J1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="181" mass="20208" checksum="FF1A3D772B142003" modified="2008-04-08" version="1">MGIQLLDKYQLQPLSLDSVPWRRQPGQQVLWIGCSDSGCDELESSGLPADEIFEYRSLGNMMVDDLSCKATLGYALDSLKIRNIVICGHYGCHIASGEVNAGLQKPWSSVLDTLRSTHRRTLDSLTGTERDRALVELNVLEQVHSLRQSAEAAEALQKQQLNIWGMVYDKATKRGYQLIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9J3</accession>
    <name>B0Y9J3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_081240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9J3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081240"/>
    <dbReference type="HOGENOM" id="CLU_026444_1_2_1"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9J3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="11">
        <location>
            <begin position="50"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP48686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="433" mass="48398" checksum="AD3AC3986D3D6D92" modified="2008-04-08" version="1">MVHQFCARPHSGGMDSTERLIDLAIQTRLFSLSNCDGWAIADEPFFVADLGQVIRQHRRWRVNLPDVLPFYAVKCNPDPNLLRLLANLGTGFDCASIEELRTVLSLGVDPCRIIFANPCKSVSSLVFAARTGVTRTTFDNLDELDNIRTFLPNAELVLRLYASDSDALINLGEKFGATVEASLPLLQRARELGLDVCGVSFHVGTGASNASAYVTAIRDAKIVFGYGKSLGFDMNLLDIGGGFQDSNLEDIACVLRPILKEEFPGVRLLAEPGRYYVRSAYTLACKVLSRRRHSGTDHHDRPDMLYQNDGVYGNFMNVLIEKETVRPSLVAYTWPFHSRGNDTRRKLEEHRYTIWGPTCDSMDCVAKDVPMTSEIRIGDWLKYKNMGAYTIATATQFNGFSNQYDVIYINTESMDHQVTHRKSVSKSIPGSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9J6</accession>
    <name>B0Y9J6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_081270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9J6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081270"/>
    <dbReference type="HOGENOM" id="CLU_061199_3_0_1"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9J6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31325" checksum="02C307767B433886" modified="2008-04-08" version="1">MSRAIDRLAEPAEKKKKKVIVASSSRTGTLGLYFAMKILGYTPYHMYEVALVQGTPGMAALLEAVIAEHNRLSGIKRFDKGDLDKLTADYDCLIEIPSFLGPALLDEYAQDPEVKIILTERDPDRWAKSVNGTAGFVVKAAASFPLNVLKHFDEELGIFLALNTTVYAVVADSTKPGQPGNEAALRRNYVEYIKAVKNTVPKDRLLVIKLEDGLGWEQICPFLGVPIPEEKYPRGNDADNFKGLVENYFRERTRAAMVRLGVLLVPALGVTGYLGWKYFGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA18</accession>
    <name>B0YA18_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_083090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083090"/>
    <dbReference type="HOGENOM" id="CLU_3124690_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="50" mass="5052" checksum="40AE2F050795FF2E" modified="2008-04-08" version="1">MCGLSGFAAHLLSPGTINYFVQVVCDVASHRACVGAGSHRNGAVRVAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAA9</accession>
    <name>B0YAA9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin-binding monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_084010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAA9"/>
    <dbReference type="SMR" id="B0YAA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084010"/>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="PhylomeDB" id="B0YAA9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000228">
        <property type="entry name" value="FAD-containing monooxygenase EthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="486" mass="55112" checksum="320FAECE4A1E1810" modified="2008-04-08" version="1">MDYDIIIVGAGISGINAAYRIQSQLPSHRYAILEARNAIGGTWDLFKYPGIRSDSDLFTFGFSWNPWNQDTPIAEGASISKYMRDTAAQYGIDKHIHFQHRLLAADWSSADNVWKLAVDHEGESKSYTARFVIFGTGYYNYHEPLAADVPGLSQFQGQVIHPQFWPQDLDYTDKKVVIIGSGATAVTLLPKMAEKAAKVTMLQRSPTYILALPNRQSSILSWILPNTVNRKLQRLRWIFTSRLFFLFCQTFPWMARLLLKLSVVRQLPKNIPHDPHFKPRYKPWDQRLCICPDGDFFKSLHTGRADVKTDTIRQVTTSGIELNSGDFLDADIIVTATGLKLQIAGGTSITVDGEKQRVPDKYLWNGVMLQDLPNASFVIGYTNASWTLGADATALFVCRLLKWMEQHHKIAAVPRLNPMLAKQMQPRRLLNLNSTYVTAAEKDLPKAADRGPWQPRDNYLSDLMFAKYGRLDEGLEWVDGGWKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB17</accession>
    <name>B0YB17_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Translation elongation factor eEF-3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_091240</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091240"/>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="PhylomeDB" id="B0YB17"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.20:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="447"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="690"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="997"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1032"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP48407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117768" checksum="FD7A28D933A535A7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB74</accession>
    <name>B0YB74_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-containing alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_091810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091810"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="PhylomeDB" id="B0YB74"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF4">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="341" mass="36682" checksum="E6484AAEC84AE879" modified="2008-04-08" version="1">MQAIRVGSAPSSTAPYSSSNPAPSSALYLDQNVPIPRPSKKGELLVRVKATTVIRDMLTWPETYRQEHSMLGNDLSGIVAEVFSEDGKFRPGDEVFGMSNVHRAAAWAEYGIVEESEIALKPKRLSWEQAAAIPLSAQTAYEALFDRVGVPVPSVEDAARNRSRTSGEGQPRLLITGAAGAVGVSLVQLASLAGLHVVAATSSNTRNAEFLRDLGAHETVEYGMLESHSSAYDIIIDTVGGDVLAPCWNYVKENGTLVSVDSASYNFVEDHEKRGTRRAGVRVLFFIVQGSSEALHYLAELADSGLVRPFVAGTYPLAKAQEAYDTANGRYPGRGKIVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBA8</accession>
    <name>B0YBA8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/FMN-containing isoamyl alcohol oxidase MreA-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_092150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092150"/>
    <dbReference type="HOGENOM" id="CLU_018354_4_4_1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="PhylomeDB" id="B0YBA8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="592" mass="64489" checksum="CA3C18ED2D4E0F6A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBA9</accession>
    <name>B0YBA9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C6 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_092160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092160"/>
    <dbReference type="HOGENOM" id="CLU_011409_6_0_1"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="PhylomeDB" id="B0YBA9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55608" checksum="ABE6E3046D9E7AFB" modified="2008-04-08" version="1">MSAAQQRAVLDPAPVAWTKPSTDHRLVLRPGTREERQYIEFFCTRTSRALSGFFDSDLWQYLLPQLSHSEAGIRHAAIALGALHQHLHRVLSKGKCDPAASKITPQNEYFIIQQYNSAIRHLVAQLSSTTSHHVPHLTLISCCLFVSLEILSGHVGKALDHIEAGLKILQRWEHRTDGKLPSEAITRELAYFLLRWNTQLSTQGRKMIPLNLSQLDTAESGGNQESWSEISEAREALVLLSNRTMSFVEAVGTDRKTRGSPGQVRQQQALLQALAAWLRAFECLMKRCSRRLKKTDPRGPVLLRIQHRTNQILASVALSRDELIYDQLDEDFRAIVSYAEDLIELNASLDKDSVLSVFSLESGLVSSLGYTARKCRNPVLRRKAIRLLYRCPRKEGLWGVQQYAVIARIIVQAEEAAVAHLPLAQRIPEDRHRVYTVHIQNRNCSSCRLVLMYLPENGDGEWHCRVREVEFAAEVQAEDPNFFAEAGISLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC15</accession>
    <name>B0YC15_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NIMA interactive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_088560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088560"/>
    <dbReference type="HOGENOM" id="CLU_010128_1_0_1"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="PhylomeDB" id="B0YC15"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF4">
        <property type="entry name" value="SSX FAMILY MEMBER 2 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP48146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="63090" checksum="EE46D06E7747B027" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCM3</accession>
    <name>B0YCM3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein (Pth11), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_090700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090700"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="PhylomeDB" id="B0YCM3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="301" mass="34140" checksum="6D4A6A759F6D323D" modified="2008-04-08" version="1">MYTRGVILRTVAIDDYIQNGYGVHIWNLYLVKLKPFKQNDLAAEDIFALGIWFVKTSILLFYLRLNPERRFRQWTYGIMAFVFVYSLISILVFTCGCIPVTAMWDMTQMATAKCVDQLAFVYANAAFNLLSDLMTLILPVKLCWALQTTLKQKVLLCVVLAMGSFACVIAIVRIVTMMPFVHSMDFTWYKVTLAKWAMVEINVGIICACLPVLRPLLLRVVPQLAGSKNSGADKQSDESYTLRDAVPRKKKGIRNWDYLTTVGGTQNPREDDVESVHVRPNGKSESQEGIILSTETKITYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD03</accession>
    <name>B0YD03_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Camp independent regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_093810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093810"/>
    <dbReference type="HOGENOM" id="CLU_028895_5_1_1"/>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="PhylomeDB" id="B0YD03"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="480" mass="52116" checksum="5BC101DF7C0E8C10" modified="2008-04-08" version="1">MVNGTAAVLEPTFTGYVATTQDALILFEACLTGILHHVPRRPHDRERSHLVRSGSVFIYEENSSGIKRWTDGVTWSPSRILGNFLVYRELEKPFPPGEKKRAMKKANRRPVPSARPGEPYPRHDSNGGSYSPSSTSGSFGDRSHQSDVERALVGSLVDSYGFKDSGLVKKTMSVTVSGVTHHLVSYYSVEDVMRGVLNPPSMVESLRYIRPRAELTQKQSFRAPIDDLETGGLENPNDPSHAIYGYRPQLMAPPGYAMPNPHPEFYLHTAPYTASHAPQSAPIPGYSIGSSMPAQPAPNPYLPAPSAPAHVQQKTEDYPQYRNPNPAPSAYGTSFDSISHAPLSSSMPSTLNSSIPSSLSERNRSTSDQSVSAYRNSSISSRSVATDVTSPIDPSTPATFSRGNSFSLSGHMDGPSQQPPEQRGIAPAFDPSIPRRESIPAHYYAGSDRPQYYMGATAPAAHASYPVSTWTTAAPAQPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDL2</accession>
    <name>B0YDL2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_095980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095980"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="69594" checksum="D00C54D4C18376FE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDQ1</accession>
    <name>B0YDQ1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">GATA transcriptional activator AreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_096370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096370"/>
    <dbReference type="HOGENOM" id="CLU_009509_0_0_1"/>
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    <dbReference type="PHI-base" id="PHI:123459"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
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        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07573">
        <property type="entry name" value="AreA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="665"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="572"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="718"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="762"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="845"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP47785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="881" mass="94490" checksum="E59F4AF9DB3290B5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDS0</accession>
    <name>B0YDS0_ASPFC</name>
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        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_096570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_915199_0_0_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="B0YDS0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="245"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="304" mass="34462" checksum="95BB9EA6606A5AB3" modified="2008-04-08" version="1">MPTLGTVGTLEEDSYRTTVEESTIPIDPLILDDEGPSEATEQRPTVDQTGNCSLDGQGTTYPFPEPLVVIQNHPDRHLESVECPAFREAKVYSYDRAHSCERSQEVRPTRQSCQPDVPSCDGRAQSPHNGRPSHSRARKRKCGRTLRPDRRPTKRLRATAVVYEKEGSFSTLSSHFSASPVAERLQFLSWLFEGALPRCMSDLKRTADIAPPTVEKEGGGLRSSRRLTRSRERVPAIDNSDMRRLSSRKGMPWLPEEEDLLVKLRREQGLPWSVVARLFSEQYSGRSQGSIQVYWSTHLKDKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE17</accession>
    <name>B0YE17_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_097520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097520"/>
    <dbReference type="HOGENOM" id="CLU_993873_0_0_1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="PhylomeDB" id="B0YE17"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="280" mass="31718" checksum="74427BBCC1FF2C10" modified="2008-04-08" version="1">MTSLFLSRRELTCRHPVASFAAVSAFSFPSMPLLLGRSCSSSRTCRLPFILSYGSIAGDAWYRAQYMLQDQKIGHYMHIPPRAVFFSQVFGTVLGIPINYAVMRWVLSTKRDVLTGAKPDPLHQWTGQSLISSNTLGVQYAVIGPAELFKKSEMSPLPWSFLLGALLPPALYGLHRLLPRWRIDLWNVSIFFSGLAVFYGNLSTGYTSAIIGGYVVMYWAYRKRFEVWKRYGYMIAAAFDAGFNLNMLLIFLFFGSGRQISMPHWWGNNPDSVERCFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEE1</accession>
    <name>B0YEE1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_098860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098860"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_0_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="PhylomeDB" id="B0YEE1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="78"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="337" mass="36568" checksum="C21349854F8003EE" modified="2008-04-08" version="1">MSVQNWEIRACRAKDVLLNSVPKEWILPAHKLPPAHQKNVEDFPRKSGILSDREVSITEMSATALVAGMGAGLLSAEEVVVAFLKRAVLGHQLLNFATEFMAERAISRAKKLDEYFKRTGKLVGPLHGVPISVKEHIEIKGRTCNAGFVAWVDDIANEDALLVQYLERAGAIFHVRTNQPQSLMHLCCDNNLTGPTRNPYNRTLTPGGSSGGEGASMGFKCAALGVGTDIGGSIRAPAGFCGAYGFRPTALRMPATGIKVPGPGQESIHGTAGPLASQSVEDLNLFQRAVIDQEPWETETSLVPLPWRQVKATKNMTVGIMWDDGYSLNLNHYSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEF4</accession>
    <name>B0YEF4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_098990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEF4"/>
    <dbReference type="SMR" id="B0YEF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098990"/>
    <dbReference type="HOGENOM" id="CLU_013615_12_1_1"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="PhylomeDB" id="B0YEF4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000050">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="120" mass="13214" checksum="17F731D701647962" modified="2008-04-08" version="1">MGLEKQTLRMGNGKDHPQPGDPVELNYTGYLYDESNPDHHKGKEFDSSKRRGPLKATIGAGDVIRGWDEGVRQMSLGEKAILTMSGEYAYGEKGFPGLIPPNASLVFEVELLKIKDHGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEZ0</accession>
    <name>B0YEZ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_100980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100980"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B0YEZ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08951">
        <property type="entry name" value="DR_C-13_KR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="274" mass="29921" checksum="60F4A59DBE0CB706" modified="2008-04-08" version="1">MPINHLTSATRHLPNMVRVLITGSADGLGLEAARQLANRGHTVYLHARNEKRAADAKAACPGAAGVLTADLSNLAETRRLADEANAIGQFDAVILNAGMLYGPFRKTPDTSIPAMVFVNVVAPYILTCLLRRPKRLVFISSQLHRQGDASVEDIFWFKRGEGRFQDFPAYCDSKLHVLLLANAVARRYKDTSVVSVHPGWIATKLGGEGAPDKLEDGVDTYVMLAEGDYDQNLTGKYFEPKRVLGRPLPASEDINLQEKVVKACEEVTGLKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF33</accession>
    <name>B0YF33_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain oxidoreductase (CsgA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_101410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101410"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="PhylomeDB" id="B0YF33"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="251" mass="26936" checksum="4B0E2020A278F8E7" modified="2008-04-08" version="1">MSTYLITGASRGLGLALAHHLANLPGSSVGTIFATSRSEHPNLQELSQQSDRVKWVQCDVTDSASVHDAVTAVQGQLQGQGLDVLINNAGVMPHTMGRIANMDDLTETFHTNVTGTHNVTRAFLPLLREGRRKLVVNISTTLGSMTLAPVYKGSPTPAYKITKAALNMLTVQYAQDYASEGFTFLVVSPGWLQTDMGGSRADLPPATGAQGVLDIVQKTTPSQNGKALNIHVPGWEENEGLNQYDGKEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF84</accession>
    <name>B0YF84_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore wall assembly protein Dit1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_101900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF84"/>
    <dbReference type="SMR" id="B0YF84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101900"/>
    <dbReference type="HOGENOM" id="CLU_038280_1_0_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="PhylomeDB" id="B0YF84"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="546" mass="60694" checksum="F6E45020FEDD7761" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJN9</accession>
    <name>H9CJN9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_m0390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="3"/>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353058.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJN9"/>
    <dbReference type="GeneID" id="11948086"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFE02839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="258" mass="30309" checksum="B133D4A803319F41" modified="2012-05-16" version="1">MVYQSIQFNPFYLVSPGSYPLFTNISLFFDNLFIGLQNILSSFINNNLWYCYILLIFIFSILLIILLFILVIDRQKGYSVKMNNLPNNENSKKRKSGNEDSSSPKENKPKLFFPKEDEDTNSYRHYMVKYDSYVRNEVSFDPIGTRKQVEDTFPSLYSEYKKYKVNNPDLEWGKLTDIYYCTWNKRPFGSYKYSGDDEGFAAVFEYMERRKVLIESGRVKGNLSMASSMCKKAWGNIDFTTYEKYIKIIDNVANKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMK5</accession>
    <name>B0XMK5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_003070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003070"/>
    <dbReference type="HOGENOM" id="CLU_059439_1_0_1"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="PhylomeDB" id="B0XMK5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072697">
        <property type="term" value="P:protein localization to cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="320" mass="36938" checksum="92954C8706E0E0CE" modified="2008-04-08" version="1">MLLLDYQNVLIQNLLTERFSGGAPVSIDQVVSDFDGVTFHLSTPESKTKILISIHVKCFKELVQYGAQEVLEREYGPYIVTPEPGYDFSVQIDLENLPAEQEARDELIMRLALLKRNAMAAPFERAFDEFAKLSEEASRYTSESAPQGVKEGGELMAIHYREEEAIYIKASHDRVTVIFSTVFREETDRIFGKVFLQEFVDARRRVVTLQNAPQVLFRSDPPLELQGVPGLQTAGDGKMSYVTFVLFPRHLTPQRRYENISHIQTFRDYFHYHIKASKAYIHTRMRKRTADFLQVLNRARPENEERERKTASGRTFRVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMK7</accession>
    <name>B0XMK7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc metallopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_003090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003090"/>
    <dbReference type="HOGENOM" id="CLU_023057_1_0_1"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="PhylomeDB" id="B0XMK7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="414" mass="46445" checksum="FDE35522987C5313" modified="2008-04-08" version="1">MRELDPLVSEYQHDKHRPREAEALLMLRKIASLVKPIMRQRAWRVGTLCEFYPQQRNLLGLNINAGQKICLRLRYPSDERQFLPLEQVVDTMLHELCHIVHGPHNQQFHALWNQLRDEHEELVMKGYTGEGFLSQGKRLGGRSMPIDEARRVARAAAERRRTLAAGSGQRLGGAPVLRGTDMRRVIADAAQRRIDVTKGCASGADNSVELAEEASRNGFRTKAEEDDANERAIMEAYIDLIQEEERERYGPSYIPPSQEIPAGPRSAPSPPPVLENTRSTSSAEPQDPIDLTYDNASYEQPWTCPTCTLENPANFLCCDACASERPRPSATRSLSGPPATGSCRTDNHNKKKRPISQSASQTIFKNRTRAVETLAALDSSIAKRPLGWICQTCGTFMETEWWTCSNCGMMKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMT1</accession>
    <name>B0XMT1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_014060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014060"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="PhylomeDB" id="B0XMT1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="90"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="537" mass="58331" checksum="EDABA7110A917CCF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMU0</accession>
    <name>B0XMU0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_014150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014150"/>
    <dbReference type="HOGENOM" id="CLU_005801_0_0_1"/>
    <dbReference type="OrthoDB" id="5572782at2759"/>
    <dbReference type="PhylomeDB" id="B0XMU0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758184" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="41"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1068" mass="118280" checksum="7A3752E324CF2C50" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMU9</accession>
    <name>B0XMU9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS allantoate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_014250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014250"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B0XMU9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000453">
        <property type="entry name" value="MFS allantoate transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="513" mass="57007" checksum="86560B6684660D9E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN74</accession>
    <name>B0XN74_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_014830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014830"/>
    <dbReference type="HOGENOM" id="CLU_029940_1_4_1"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="PhylomeDB" id="B0XN74"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="309"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="584" mass="65092" checksum="4933D1E26F6C94F3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN75</accession>
    <name>B0XN75_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_014840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014840"/>
    <dbReference type="HOGENOM" id="CLU_019101_2_1_1"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="PhylomeDB" id="B0XN75"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760347" description="Rhodopsin domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="75"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="296" mass="33103" checksum="16682635AC174F45" modified="2008-04-08" version="1">MLFAVLWYTLLCVALNQVASGGGSNLMTDEDIANLTPATHAERVKGSKWVFVSEHSFVLAIWAMKVCMLVIYFHQCSSYQYYEIIQGAISISADIFMLAVAIPLLVQVRVPLKQKVILLALFGMGIFVIVAAILNKIYCLVPSLISYVYMNWYFREATVAVLVTNLPLVWSLLRDVFPALKSWTGGSKKGTDRYRSGPWTSKGSGLRAYGPASQLRSGDYNMQDYTSTSTAMHHQKAVSDVSVNQSDERDLSDDGSDRALRIRQDVTVTVERETRPPEYWDTHHAQIANGRPQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNY8</accession>
    <name>B0XNY8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_016140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016140"/>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="PhylomeDB" id="B0XNY8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071454">
        <property type="term" value="P:cellular response to anoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="337" mass="36636" checksum="CF0A5F0EA56D895D" modified="2008-04-08" version="1">MSASIPGNRDLPASQYDLNTYWGRVRHAADISDPRMLFVSPSGLEQAKRLISSYKQNHIPVMTPELWRAKKVVDSTLHPDTGEPVFLPFRMSAYVLSNLVVTAGMLTPGLRTTGTLLWQIANQSLNVAINNANANKSTPLSVSQMAKSYLMAVSASCSVALGLNALVPRLKNISPNTKLILGRLVPFAAVSSASALNVFLMRGEEIRQGIDVYPVLSEEEKKKREETGEPVHSLGKSKKAATIAVGETAISRVLNATPIMVVPPLILVRLEKTAWLKARPRMVTPINLGLILATSLFALPLALGAFPQRQAISAQSLEEEFWGRGGKDGQVEFNRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP49</accession>
    <name>B0XP49_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_005920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP49"/>
    <dbReference type="HOGENOM" id="CLU_017171_2_0_1"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="PhylomeDB" id="B0XP49"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Glyco_trans_8"/>
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        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
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        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="301"/>
            <end position="320"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
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            <end position="412"/>
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    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="531"/>
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            <begin position="604"/>
            <end position="623"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <begin position="390"/>
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            <end position="544"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP55892.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
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        </source>
    </evidence>
    <sequence length="722" mass="80476" checksum="EF80420B186F7197" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP81</accession>
    <name>B0XP81_ASPFC</name>
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        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_016410</name>
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    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </reference>
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        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
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    </comment>
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        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
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    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
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        <property type="project" value="UniProtKB-UniPathway"/>
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    </dbReference>
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            <position position="112"/>
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            <name>NAD(+)</name>
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            <name>NAD(+)</name>
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        <ligand>
            <name>NAD(+)</name>
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            <name>NAD(+)</name>
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        <ligand>
            <name>substrate</name>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_016550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016550"/>
    <dbReference type="HOGENOM" id="CLU_001265_2_0_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="PhylomeDB" id="B0XP95"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF60">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="557" mass="63460" checksum="B2C45A3788915EFB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPF4</accession>
    <name>B0XPF4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ and TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_006290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006290"/>
    <dbReference type="HOGENOM" id="CLU_015935_2_0_1"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="B0XPF4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="556"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="693" mass="76148" checksum="709102BF7FF1A9BB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPI6</accession>
    <name>B0XPI6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome biogenesis protein Ssf2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_006610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006610"/>
    <dbReference type="HOGENOM" id="CLU_026936_2_0_1"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="PhylomeDB" id="B0XPI6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="31"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="445" mass="50208" checksum="735D6AA65A4DB9BC" modified="2008-04-08" version="1">MAKARTKKRTHVRAQNASAAAKNSMSKTPRSMVIRVGASQVGSSVSQLVKDVRLMMEPDTAVRLKERKSNRLRDYTTMAGPLGVTHLMLFSKSATGNTNMRLALTPRGPTLHFKVESYSLCRDVEKALKRPRGGGQDHKTPPLLVMNNFNSPNATEDSKVPKRLESLTTTIFQSLFPPINPQATPLSSIRRVMLLNRELTAGSEKEEDSYVLNLRHYAISTKKTGISKRIRRLDPKEIRSREKRKSAVPNLGKLEDAADYLLDPSAAGYTSASETELDTDAEVEIAGSTTKKVLTKRELQRMKSGEKAKAQKADTPEVEKRAVKLVELGPRLKLRLIKVEEGLCEGRVMWHDYIKKSEEEVKSLDKNWAKKKKEKEERKKQQRENIEKKKQEKAKARAEGRGGEDDGDEEDVDMDDEDDWLSDDLEDDEEGQAQDNDDEDESMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPP4</accession>
    <name>B0XPP4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_007100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007100"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_1_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="PhylomeDB" id="B0XPP4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="530"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="564" mass="61032" checksum="B0E9769521793664" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPR7</accession>
    <name>B0XPR7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_007330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007330"/>
    <dbReference type="HOGENOM" id="CLU_022986_3_0_1"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="PhylomeDB" id="B0XPR7"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000090">
        <property type="entry name" value="Lipoyltransferase and lipoate-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="76"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="453" mass="50353" checksum="422FED18EA56EAC4" modified="2008-04-08" version="1">MRRLLRGQCLLTSALAPRRSGSSPYEGAVRYNSALSTDHFAHLASRQSSRHQIYQSLSSDPYVNLSIEHFLLEHAPVDSSILFLYVNRPCVVIGRNQNPWLETNLEALYNDRVETQKGDDESEDVLLVRRRSGGGAVFHDFGNLNYSVISPRTTFTRNKHAEMVVQALHNIGATNTSVNDRHDIVMTSGTSEHGGSGASLPRKISGSAFKLTRHRALHHGTCLLDSPNINDLGFFLRSPARDYIKAKGVDSVRSPVTNVSTAFEDAFAPFSIQAVMEGIMEQFAQLYQVSPDAVRRAQRAHANEPELYAGSDWVAGVVGAQEGYGELEIRKGIDELRSLEWKYTQTPQFTFSTFPFEEDPRQRPTLPESLPPSTRVFLRFKHGAIVESEISVSSDSDVASEQARRVHEVLNGLKLHEIQLSQWDQLLTNRLGTGVEATVAHELARFIGSKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPZ0</accession>
    <name>B0XPZ0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_008050</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the FACT complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008050"/>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="PhylomeDB" id="B0XPZ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="15">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="16">
        <location>
            <begin position="541"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="17">
        <location>
            <begin position="814"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="935"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="951"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP56104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1019" mass="115253" checksum="4CF8A5F479748331" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQL4</accession>
    <name>B0XQL4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vesicle-mediated transport protein Vid24, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_010370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010370"/>
    <dbReference type="HOGENOM" id="CLU_028759_0_0_1"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="PhylomeDB" id="B0XQL4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="330" mass="36984" checksum="FDAEF1C121C93D84" modified="2008-04-08" version="1">MPTPSDNTSPLNVASITEDISTHTTCPPEVERLSSWRDSPEPSATESDVPDNASSPSIRSAHTLLTAQPDGTINQSNTDVSGVASGHTAPEKGTMRSDDEVALGRLSPTRGTASSAKPTSTVASPSTASLLSYEFSNVRLLPNYTSSYLRPGSKFTGTQQSDRQVYNVDVEIKHVDMAESYLCGYLRIQGLTEDHPTLTTFFEGEIIGIKHTFKTRNEAWGATEKTDMHHWARFPAWRPLAKQAKKPDFTYWNFAEREHIFMRWKEYFLVPDHRVRTISGASFEGFYYICFNQIEGSVTGIYFHAKSEKYQQLELKHVEDHGCTPAMEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQX7</accession>
    <name>B0XQX7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_011520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011520"/>
    <dbReference type="HOGENOM" id="CLU_051867_1_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="PhylomeDB" id="B0XQX7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.210:FF:000011">
        <property type="entry name" value="Acyl-CoA thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="244"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="366" mass="40989" checksum="581B2F8DEDB76506" modified="2008-04-08" version="1">MSSKENGPSSPGKLPFCASFAELMGLKRLDSPSSTPDAPEKVERFESLAVPYSPGMSGIAFGGHVYAQSAYAASKTVDKGFVIHDMTGTFILRGRLDVPYEYTVRHMRDGSMYCTRAVDARQNGKICFSCLCSFKRSEGQQTFHHQPGPAQERFRALLAGKKPEDHPRSPSVDADWWIEQVQRGNIAEPEFPGLDVRKVDMTSYNATEEVKQSPEKYRQLTLYALKGSPHDSDVALSKQDLKARDQTGEFDNLYACAHMYASDKNSLLLIPRALGHKTWSAMASLTLTVVFHHHGEALRMIDWDVGQEEDGKRLPRKWFIQEGWTPTSGENRAIHESYLWSPDGVLLATSYQDSLLRLQNLGRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRL2</accession>
    <name>B0XRL2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_013070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013070"/>
    <dbReference type="HOGENOM" id="CLU_010064_1_0_1"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="PhylomeDB" id="B0XRL2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000074">
        <property type="entry name" value="Spindle assembly checkpoint component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
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    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="238"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="347"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="731" mass="83484" checksum="DAF3E1B7CB33231A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRS9</accession>
    <name>B0XRS9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease (Dip5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_024710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024710"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B0XRS9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="46"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="563" mass="62447" checksum="028AF2C55F663B5E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS72</accession>
    <name>KYNU1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kynureninase 1</fullName>
            <ecNumber evidence="1">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Biosynthesis of nicotinic acid protein 5-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">L-kynurenine hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bna5-1</name>
        <name type="ORF">AFUB_026170</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the kynureninase family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="1"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS72"/>
    <dbReference type="SMR" id="B0XS72"/>
    <dbReference type="EnsemblFungi" id="EDP54558">
        <property type="protein sequence ID" value="EDP54558"/>
        <property type="gene ID" value="AFUB_026170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026170"/>
    <dbReference type="HOGENOM" id="CLU_003433_4_0_1"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="PhylomeDB" id="B0XS72"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000356963" description="Kynureninase 1">
        <location>
            <begin position="1"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <sequence length="509" mass="57148" checksum="FAB6BF3A24F37D13" modified="2008-04-08" version="1">MGSRLHVQVIHGGPPLPYKDDIRAFGKEYAEQLDAQDPLRRFRDEFIIPSKKDLKRKTLFPNDGMYSCGHPICFANTSCACVHAAETEETSDEKCIYLCGNSLGLQPRSTRKYIDHYLRTWATKGVTGHFVPHDDQLLPPFVDVDEAGAKLMAPIVGALKSEVAVMGTLTANLHLLMASFYRPTPERNKIIIEGKAFPSDHYAVESQIRHHNLDPKDAMVLIEPEDLDRPILDTKYILRVIDENAHSTALILLPAIQFYTGQYFDIQRITAHAQSKGILVGWDCAHAAGNVDLRLHDWNVDFAAWCTYKYLNAGPGGMAALFVHERHGRVDIEQAASGKEAFHPRFSGWWGGDKQTRFLMNNHFVPQQGAAGFQLSNPSVLDMNAVVASLELFNQTSMAEIRKKSLNLTGYLEHLLLRDPQTENSEKRPFSIITPSNPAERGAQLSIRLQPGLLDRVLESLNEDAVIIDERKPDVIRVAPAPLYNTYAEVWRFAQLFHLACDKALCGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSP9</accession>
    <name>B0XSP9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HET domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_027950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSP9"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="PhylomeDB" id="B0XSP9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="597" mass="66233" checksum="9BC4ECC655FD95C1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT87</accession>
    <name>B0XT87_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">AFUB_018400</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018400"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="PhylomeDB" id="B0XT87"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000138">
        <property type="entry name" value="Potassium/sodium P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="839"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="927"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1012"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="75"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EDP53796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1079" mass="116299" checksum="DC754F562F6AA09F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT89</accession>
    <name>B0XT89_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_018420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018420"/>
    <dbReference type="HOGENOM" id="CLU_2775486_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="69" mass="7474" checksum="8473D5A53D664B6A" modified="2008-04-08" version="1">MANIDGGKGPTVLRSVHILENVEQPRQPGSDVTGFGLFLSQGTRVKNVRQIMAAQSAFRSASMDWLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTJ9</accession>
    <name>B0XTJ9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glucose oxidase</fullName>
            <ecNumber evidence="12">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_018840</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="12"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018840"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="PhylomeDB" id="B0XTJ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758334" description="glucose oxidase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP53840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="599" mass="64967" checksum="2890CE8925EBCA84" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU75</accession>
    <name>B0XU75_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_030590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030590"/>
    <dbReference type="HOGENOM" id="CLU_035327_0_0_1"/>
    <dbReference type="OrthoDB" id="4187489at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="571" mass="63463" checksum="62681FEC6234A499" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUC9</accession>
    <name>B0XUC9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bax Inhibitor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_020290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020290"/>
    <dbReference type="HOGENOM" id="CLU_046868_1_0_1"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="PhylomeDB" id="B0XUC9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="337" mass="37103" checksum="5F8C9BF44F442FB0" modified="2008-04-08" version="1">MAFFLRRPFAVPTALRQAPKAANTARFIHNSPIKPVQSKPLGPCSSSIFAQSKQTIQNAFRRTYMQQSYGTAQRGDLTQRLLYGAAIVGGTVMATNFIFNRETREDGGMPHYERSYLNETFMHTGLGVGIIGIAARALHMNGWSYRLMATNPWLVAGVGLAASMGTMFATYYTSPDNYVMKYGLWAAFNVTQAALLSPLMFMHPALLARAGLYTVGMMGSIAFVGATAKQEKYLYLGGPLLAGVTIVALSGLAPLVIPATAARALMWSEKIWLYGGLAVFGGFTLYDVQKILHHARLAERGLVRRDVVNESISLELDFINIFVRMVQILAMQRNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUH3</accession>
    <name>B0XUH3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein Pso2/Snm1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_030890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030890"/>
    <dbReference type="HOGENOM" id="CLU_005260_4_0_1"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="PhylomeDB" id="B0XUH3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="690"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="850" mass="93196" checksum="7FA24A917223099D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV14</accession>
    <name>B0XV14_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_021300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="PhylomeDB" id="B0XV14"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="16">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="15">
        <location>
            <begin position="133"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP54080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="431" mass="46817" checksum="FDA6448FC4EAB32D" modified="2008-04-08" version="1">MASWLQIPKNSPFSLANIPFGIISSAKITSPVAAVAVGDYALNLSIFASSGGFSQLPVIQPHLGVFSQPTLNAFAALGRPVHRQVREYIQSVFRADTPFPQILKDNSTLQKEALLPLSEVTNHLPMHIGDYTDFYAGLNHAYNVGVLFRGPENALQPNYKHLPVGYHGRASSVVTSGTPIRRPNGQILANPAANPKVPTFSPCKRLDIELELAAFVSKSNELGKPVSIDEAEDHIFGVVLMNDWSARDIQAWEYVPLGPFNAKNFATTITPWVVLLDALEPFRTAGLEPGNRESLLPYLREKRELNAYDIPLEVEITNAGGKPTLISRTNAKNLLYSFPQMLAHHTITGCNMNTGDLLGSGTISGKENQTQGSLLEQTNGKNPLKLADGSERLFLEDGDTVVLRGMAGTEGNYVGFGDCVGTILPALKLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV24</accession>
    <name>B0XV24_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_021400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021400"/>
    <dbReference type="HOGENOM" id="CLU_022040_1_0_1"/>
    <dbReference type="OrthoDB" id="5402307at2759"/>
    <dbReference type="PhylomeDB" id="B0XV24"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="50701" checksum="A5E7EA4A7C1821A2" modified="2008-04-08" version="1">MPPLGETIAVIDKSGKVVSTSKHLFGVFTQAKNAYRERKAQIQSERNAKIAEREALRALQNYHIDDAPPSVAPSRRSRSTHSRHHRHRRAPSHYEQDLHSVASQTESYYASPSDMVRRHTHHDITRELEPQPRMDRSKSEAHVDMDLAYGEFHPSALIRAPSSQQQQLQRIEDPELNGLVDRAQWLLEEANCVHHSATATIAHLQKNPDAMAAVALTLAEISNLATKMAPSALATLKSAAPTIFALLASPQFLIAAGVGLGVTIVMFGGYKIIKKIQSAGNEVIRGPTEDDGESVIVEDMIEFDTDCLSGVEMWRRGVADAEADSLGTSVDGEFITPTAAAMSGIDITTARMMRDPRFKFHDDESVASSRRSRRSRAPRGSSRHHQSEYDARAESYAGSKAPSAAPSRTHSKISSKAPSKAPSQAPSRAPSKAESRHSDKDRKPKEKKRRSSRLRLMFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVC0</accession>
    <name>B0XVC0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nuclear protein SDK3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_032590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032590"/>
    <dbReference type="HOGENOM" id="CLU_049352_2_0_1"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="PhylomeDB" id="B0XVC0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="10">
        <location>
            <begin position="82"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="311" mass="35472" checksum="F5E69D5AE21DEC7E" modified="2008-04-08" version="1">MAEGTLASAVAVPEHDILPPSPDATLKRRNSSTTDPDPDSKRRRLSTQEEKDHPASDRKPSILDTAEQRPGRRASRQANGREEERKRGQRLFGALLGTLSQRSSTAAEKRRADIERKQQVKLKLQDEEYDELKKKKREERVALRKKQQRYYEEESMRTRHSNLLAMAHFLKTRSEPVLYYKPWQLRPEDEDLICRQIEEAEATISRERAEFEARHPPQEESESKEETEFQTGNQQEAPQPDADVQQPKDTTEESSDQANAGTKESQNNEASVPDTVDDIPASVNHTGSDDHRAADDDGGEVVEDNEDTVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVP5</accession>
    <name>B0XVP5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin-binding monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_033180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033180"/>
    <dbReference type="HOGENOM" id="CLU_006937_7_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="PhylomeDB" id="B0XVP5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="594" mass="67091" checksum="6C2E3654AF02C948" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVS7</accession>
    <name>B0XVS7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MT-A70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_022620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022620"/>
    <dbReference type="HOGENOM" id="CLU_027091_4_1_1"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="PhylomeDB" id="B0XVS7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="455" mass="50901" checksum="CE34DBDA56C27978" modified="2008-04-08" version="1">MMPHSILYQNAEKTILLIDIPTSIACAQELSPVQLGATLCNSHPTEAGIDYHRKRHLLSSSPLEKPYAVSTEPKSDAARARVLSRLPVSERAYQTEIIEPLVRGALQEISRAHLDSAEWCLERKVLEQETQLKRKRDETRSRNSPCEDGCSADDALGVSAPNSPPIILSPGLNMFESLPEICNVLVRNTSLAQAVLDVRCKAEHEPEHREQTTTHRHVFFVPPFSTFLLCELPLSAEDEASQGPIPGLSLDRKFNLILLDPPWSNRSARRSGHYQTQSYSDIGLLSKRIRDILKAHLSDDSQCVSIAAIWITNAAKARRAAYDAIKGAGLSVYEEWMWIKTTTKGEPITPLDGLWRKPYEILVIGRRINRWPSDAADAITRRVIAGVPDVHSRKPNLKEVFEQVFFSRTGSGAKTGHTCMAYSALEVFARNLTAGWWACGNETLKFNSEDWWVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWA8</accession>
    <name>B0XWA8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NEDD8-like protein (RubA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_024160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024160"/>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="PhylomeDB" id="B0XWA8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="80" mass="8992" checksum="029AA629D1ACA6BE" modified="2008-04-08" version="1">MIYFRVRTLTGKEIELDIEPDYKVSRIKERVEEKEGIPPVQQRLIFGGKQMADDKTAAEYNLEGGATLHLVLALRGGCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWC0</accession>
    <name>B0XWC0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_024280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024280"/>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="PhylomeDB" id="B0XWC0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="114"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="188" mass="22070" checksum="9BE2B9170BD96C5D" modified="2008-04-08" version="1">MVRQLKYHEKKLLRKVDFINYKSDGGHREHQIRQRYHLQNDTDYKSYNALAGSLRQLAHKLSQLDPDSDPLRKKIESEVLDKLWRMGLLKQSREQGAGLSRVEREVTVSAFCRRRLAVVMVRTGMVETIKAAVTYIEQGHVRCGPEVVTDPAYLVTRNMEDHITWVDSSKIKRNIMRYRDNLDDFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX73</accession>
    <name>B0XX73_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fatty acid oxygenase PpoC, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_037060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037060"/>
    <dbReference type="HOGENOM" id="CLU_002329_1_0_1"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="PhylomeDB" id="B0XX73"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000058">
        <property type="entry name" value="Fatty acid oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000005">
        <property type="entry name" value="Fatty acid oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126412" checksum="E10704AB4F332DD4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXJ3</accession>
    <name>B0XXJ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_048530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048530"/>
    <dbReference type="HOGENOM" id="CLU_1524781_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="176" mass="19942" checksum="7221C8E06A1D342A" modified="2008-04-08" version="1">MQVAEAETPSMTASNNDGDDDFLTLFGAFTVSEKPIPPMSWVEGELAAMDMDNLDQSPQCCRDLQEGYHSDEALLSDMAIDRPPRQGAGLRRSPRNKSAGGVQTPYVNFVADAPELANRLSKARRERKFLRRMGKQSTLAYERLSREIEQLRAIIQPNWRERPHSRRGNNKEHTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXN1</accession>
    <name>B0XXN1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_037990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXN1"/>
    <dbReference type="HOGENOM" id="CLU_993892_0_0_1"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="PhylomeDB" id="B0XXN1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="247" mass="26654" checksum="DC0F1D8083A5EDC1" modified="2008-04-08" version="1">MLHASRKRVRSDSIPDRPSKAPRVSWKGSYHLPASSPGFHHHAAHRHQPLPFVAETIPEFSSPAYHPHSDEENDPDLPVHSFQHASSMVGSSPPRTPPPKHARLAHKDPNLLHEDGADLLLYLANSPTPASIAGKTQARDFPPSTPPSQHALLPTLTPTPGGGGVFPNFGTPSRQFNFADFVNVTPSPAQPARGGRTPGGPMKTPLANRDTRKRPNFDNLLPPSAESPNNRPKESGLALQLGGELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY01</accession>
    <name>B0XY01_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_039160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039160"/>
    <dbReference type="HOGENOM" id="CLU_041456_0_1_1"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="PhylomeDB" id="B0XY01"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="137"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="251" mass="28313" checksum="41128455FB0D1F48" modified="2008-04-08" version="1">MPPKSKKQHPKPKSQPPDHPKPNWPPLRPLIPSSNLSLESLLHDQIYLIRNFLPSSLCKTYAFFLASLPLTTTPSKPKKGEAVRVNDRFQIQDADFAERLWSGTALRELVSGAVDEDQDGDGQPRSNREIWGGEPLGLNANIRVYRYSRGQFFAQHYDDSNVVAFESPQHKLQQARTTWTLLVYLTNCTGGETVFYPEPTGANRNPEPIAVAPEVGMALLHRHGERCLLHEGREVTEGEKWVLRSDLVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY13</accession>
    <name>B0XY13_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_039280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039280"/>
    <dbReference type="HOGENOM" id="CLU_1703812_0_0_1"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF24">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP52759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="154" mass="17362" checksum="4457537BEA99D758" modified="2008-04-08" version="1">MNPNPRHRRDSPRRNRSFAFPLPCNAKANPNTGLTRAPIFPTFTQTFTRCVQVWAVNHQSPEPTALSPAYAALLLAWSAADVVRYAYFGLLQAGIRVDFVKWLRPPLRRSTPSGLRSSTSALLYMFLVSLLLLEMGQGANKRMARRFHDVLVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ00</accession>
    <name>B0XZ00_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_042670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042670"/>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ00"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000038">
        <property type="entry name" value="Probable 2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000851">
        <property type="entry name" value="Probable 2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="262"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="414" mass="45601" checksum="A00DF76FD765FDC0" modified="2008-04-08" version="1">MHEADEASRGGGKRKLSGRIHILGLGNVGTFVAHSLASRPSPPPITLLLHSRDLYGAWLAKKKCLAVNTNGLDDIKTGFDVNVLSDRTWYSLPYWNQNGEPNTNGDSVTEENLEAGVEESLSQSEEDDEHIECLIVAVKAPMTARALESVSHRLTPDSTVLLLQNGMGTIEEINEKVFPDPHQRPHYMCGIISHGLARKRDAFHVTHTGIGTTIISPVVPRDALASKDEKDTDWAPSTKYLTRTLTLTPPLVAVAETPSSLLLYQLEKLALNAIINPLTALMDCENGEILYNYSFTRVMRMLLIEISSVICALPELQGIPGIENRFAPERLRSMVTKLANQTAKNTSSMLADVRSGKTTEIEYINGYIVRRGEELGIKCAVNYMIKHLVLAKQQMVKQRVSGAIPIDILEGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ20</accession>
    <name>B0XZ20_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_042860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042860"/>
    <dbReference type="HOGENOM" id="CLU_010478_0_0_1"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ20"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000999">
        <property type="entry name" value="Anaphase-promoting complex subunit Apc5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760726" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="23"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="267"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP53116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="768" mass="86732" checksum="1FEEFE9CF6C66295" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ52</accession>
    <name>B0XZ52_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IEC3 subunit of the Ino80 complex, chromatin re-modelling-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_043180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ52"/>
    <dbReference type="HOGENOM" id="CLU_038623_0_0_1"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ52"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="4">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36278" checksum="56859A3D81545E34" modified="2008-04-08" version="1">MALSWSYRKKYAKLKVKFELGMKESESLIREELRIEDLSKRIQEQNDQLLEVLLEFNESLHIPADQRFDLSAPGDSSFLPTPERSPMYVDTATAKSILKDAKAQMAAGSMTLEAYRTLEDDIKRGNAFAPRMHYTALQKVPHTAVPPLREDSSTNISLEEKLGYLTPEHETEYYLSMDAKLGDEAAALELSRIPEKPSFAERERELALRNPVSVYNWLRRNQPHIFLQDHENASEKSGSRPTNARASKRVTQPRKEEDVYDEDGVLMDTGPTPGSTKGKRKRDDDTGYRPKGGSSRPSKKKKDDTNSNAKRTSKRSSGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZM7</accession>
    <name>B0XZM7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_044590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZM7"/>
    <dbReference type="HOGENOM" id="CLU_782986_0_0_1"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="110"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="380" mass="44334" checksum="56A137DCED140032" modified="2008-04-08" version="1">MTFQFLQRFRSKDKERENGKGKARPKDQPDEDPSQSDPRTVLAQVGIYHETCKQNGNCRDFRSMPLPPPRRPLTPPDYELAAIRGRSNTLTAINTSTTNFLDLTKSTTLPQDQSLLFSRLPKEIRQRIYIELFGNRSVHLEYDFGYAPGYRQRDKRPPDQWRWWHRVCDDEEHPNPGDLCRMNDLEDPKRIGRRQLSRHKLKGVAWLRVCRRATNTFLISSSVKLCRLPKLIAPSHLSRIASLDILHVAKTTTPSTMADNEWETYHTLFRTLRLAYVGVRRLRVVIHILNKSCTPRAGTVPEELDEAWIRPWSELASSRQWEKLEIGLQDSWFDDFSAAGRRWEARNGRQLEDSGYSLARVDDFTTWDGRLSEIWNAVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y032</accession>
    <name>B0Y032_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_045460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y032"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045460"/>
    <dbReference type="HOGENOM" id="CLU_877095_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="317" mass="35435" checksum="8CA82D5CE10CE9C4" modified="2008-04-08" version="1">MPFLERSSTAVTVDGTDIFALILAIPFVIVPGIFWRSAEKWPLCDVLLLSRASEVIHWVWERAHQHQRAAMSNLLSHNPALPGHGTHGKRACGACSRKKTKCDMILPICSLCQRTGTSCVYPLRRKPRAPRVARANRSDTPSQDANLKHWTPQQNDTTIVNCRPTGLAVDVNNGMLSPAVNQLVSQPPLIHMSSDKDTSHGSPHFSLNPLEVLSPGFWDPEFTYCLPIFDLEFQQPSLQTNKGPDVPETHHADYNLLHDDSVTRHTAHQQFTPPLTDSLSVQAPQLQNIRDIFEQDTFRDLPHTLLDELQAGSILTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0P5</accession>
    <name>B0Y0P5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_058050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0P5"/>
    <dbReference type="HOGENOM" id="CLU_001788_0_1_1"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0P5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="667"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="102914" checksum="EC91BE50C805FC2B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0X1</accession>
    <name>B0Y0X1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GATA-type transcription factor sreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Siderophore uptake regulator sreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_058830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001699">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034757">
        <property type="term" value="P:negative regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000039">
        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="252"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="371"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="546" mass="58568" checksum="27F9086A98391918" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0Y0</accession>
    <name>B0Y0Y0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_058920</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0Y0"/>
    <dbReference type="HOGENOM" id="CLU_025461_2_1_1"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0Y0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="17">
        <location>
            <begin position="217"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="111"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP51871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="375" mass="44500" checksum="F2587EE6405A67B9" modified="2008-04-08" version="1">MVFEWFAELLMNTTKETVEPAMRAAAEDICGDYPDIVPLETRNLMGFFISLRRLMMECGVNDFTFTDLTKPTHDRLVKIFSYLINFVRFRESQTQVIDEHFNKTEKTKARIDTLFMENQEMEQRLEEMRRSLKANEAQVKEKVRRNDELKARLLELRRNQERIAETLERVKADKARRQAQLEEKTERSVRTRQEVEKLRPYAMQSPVSLQSALTELSENLLREKAQIDAMEKRARALQTSSDTFTVVGNDVQACIKLLEDISVELQKEEEEESRASRNKEAISERGNNVREVEQTEKLLQRQLARWNERIEALRKNAQEKAEVAQARMDELRDVQKKLREERAEKQRDMERRRIRIEQTEKKVRLRARQHVVLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y181</accession>
    <name>B0Y181_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inulinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_049000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y181"/>
    <dbReference type="SMR" id="B0Y181"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049000"/>
    <dbReference type="HOGENOM" id="CLU_001528_3_1_1"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="PhylomeDB" id="B0Y181"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051670">
        <property type="term" value="F:inulinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.560:FF:000003">
        <property type="entry name" value="Extracellular exo-inulinase inuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF1">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760621" evidence="6">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="384"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="528" mass="57288" checksum="6BFBB2D62D16C4BA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1E4</accession>
    <name>B0Y1E4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_060040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1E4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060040"/>
    <dbReference type="HOGENOM" id="CLU_044117_2_0_1"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1E4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001242">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="40606" checksum="6299EEACFBC19513" modified="2008-04-08" version="1">MLEAQQQPQAPSQPQAPMQTQKVSDIIRSFRPAKAFKGSKQEPSNYVTSLDFDDQGDYLVASGDDETIQVFDIKEGKSTKSVPSKKYGAHLARFTHHSRQVLHASTKVDDSLRLLDLHNEGYVRYFSGHTDKVTCLALSPGSDAFISCSKDDTVALWDLSSRNAQGKLKLATPYLVAFDPSASVIAIASQSTSSVLLYDFRNYDKAPFSTFDLAPYEERYTPSTRGRAWTRLEFSNDGKHLMVGTDFHGHFILDAFEGNIKAFLLGKNGSPGRAAPVSTTGKPLGQGDACFTPDGRYVLGGSGDQSDVLVWDMQQTPDANSLLQPMTKLPNRGRTAVLEYNPRYNMLATADKEVVFWLPEENSRSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1I5</accession>
    <name>B0Y1I5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_049420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1I5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049420"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_0_1"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1I5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001107">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="50948" checksum="BC03D61A7571AD80" modified="2008-04-08" version="1">MANFPAPRVDIEAKEPMPTDQSIQLEEQENPRRWPAGKKCMDLIYTAAIPSISHAYGCSSTVATLGITTFLLGFASGPLLFAPLSEVWGRNTIFRVVLGLFVLFQIGCALAPNVASMIVFRFFSGFFGSPTVTNSGGSITDIWPQDNRSVPLALFSAASFLGPVIAPTVGGFICQYTSWRWNFWVVLILSGLCYGAMMVFLPETYSHKLLMDKKRCMPGYSPANQPPVKEMLYTTLTRPWLMLFTEPILFLLSLYMALVYGILYLDFTAYPVVYRETRGWSASIAGLSFLGICVGMAIATLISPYVNRIHGIYVRRLGGPQPEARLPHLIVISWLIPVSLFWFAWTASPPTHWISGIVAGVPFGFGLILLFLGITSYLTDCYGSFGASALAANAVLRSLFGAVFPLFSTSLYHSLGTSWATSLLGFVALAMAPLPWVFYRFGPRIRSRSKYHLRTREYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1I6</accession>
    <name>B0Y1I6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_049430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1I6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049430"/>
    <dbReference type="HOGENOM" id="CLU_2885369_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="63" mass="7450" checksum="CCFCAA449107F729" modified="2008-04-08" version="1">MRSARRIAPRPLDTPAEKKKLDKSQNDYNRGYEVMYGQMIEKDTKHDLKEGFLEVRPWTEPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1K5</accession>
    <name>B0Y1K5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plasma membrane ammonium transporter (Ato3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_049620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1K5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049620"/>
    <dbReference type="HOGENOM" id="CLU_051062_4_0_1"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1K5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF6">
        <property type="entry name" value="MEMBRANE AMMONIUM TRANSPORTER (ATO3), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="269" mass="29386" checksum="1987017B335922EC" modified="2008-04-08" version="1">MNEKSDETLRRMQTAESVFLPISREAFEKLYLNPKSPTVSGDLRKKVGNPTPISLLGFLLASTTNACIIMGWRGAGGNGAAIIPVLIFFGGMVQIFGGIGEWIIGNTFSCALFFTYGTFWIVQGTTLMPFFATGIHFSSTGNFLEGQQTPMYNASIAFYFVALTVITFIYMICSLRTNVCLFSALFLLEITLGLFAGAFFSVSAGNIHLAEKLQVAGGAFNFALCIPIWWIFITQILEAVDFPVSLPVGDLSTMIPGRSQRMRSKQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y268</accession>
    <name>B0Y268_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_061460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y268"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061460"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="PhylomeDB" id="B0Y268"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF164">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP52110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="365" mass="40157" checksum="3B82BB4975711963" modified="2008-04-08" version="1">MADASGADRGWILHAVSWPLFGICVLITATRFWVRARILRSCGWDDAFILLALLCAAVNTVLVTLSIMHGTGHHMRDLSHEQQIASVKYQLLSQGFHVMSTNWGKVSVALFLVRIISGVKQHKRAMYAGMILLSIINIGGVYTIYGQCTPTAKAWDNDIKGTCWPEGAQRDYAFFQGSASAFSDLVLAVYPLFTIKDLQMATKVKFGLGFVLSLGIIAMVAAIIKTVHLAALSAKADYTWDTLSLTIWVAVEQYLIIIAACIPALTPLFNIIVRRVTSRRSKSKSTPNELGASDRKLSHPQPYLAFASVGREYVEYPMTYVGSAKDSKRRSSDSEALITTEPNSPTGILKTTEFHIQGVARYDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2A7</accession>
    <name>B0Y2A7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_050790</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050790"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2A7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1141"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1176"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1220"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1258"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1291"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1412"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="136"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="819"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1448" mass="163179" checksum="6D26E97B86061125" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2E3</accession>
    <name>B0Y2E3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sporulation-specific N-formyltyrosine oxidase Dit2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_051150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2E3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051150"/>
    <dbReference type="HOGENOM" id="CLU_031576_0_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2E3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000223">
        <property type="entry name" value="Sporulation-specific N-formyltyrosine oxidase Dit2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="538" mass="61937" checksum="350D1B0FCF17EF4E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2G7</accession>
    <name>B0Y2G7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_051390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2G7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051390"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2G7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05345">
        <property type="entry name" value="BKR_3_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="257" mass="27421" checksum="70A26585268B8795" modified="2008-04-08" version="1">MNKASAGARLQGKVAIVTGGGSGFGAAISRRFGEEGAKVIVADINVENGEKIAAQNPENLVFYKMDVTSASDWDEVMDLAFAKFGRLDVLVNNAGTTYRNKPTLEVTEEEWERVFNVNVRSIFLGSKALMGRLIQQGQGGSMINISSTGASRPRPGLVWYNASKGAVSNATKGLAAEYGPHNIRVNTVSPLLSGTGLFSMFTGMEDTPENREKFIGNVPLGRLTDPNDVANMCLYLASDEGSFINGAEMIVDGGKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2J0</accession>
    <name>B0Y2J0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_061990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2J0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061990"/>
    <dbReference type="HOGENOM" id="CLU_1712832_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="153" mass="16203" checksum="DBE7D219D32AFC74" modified="2008-04-08" version="1">MSGLDPNWYPATITGFGGAFALVQQVPSAGFGAILFMRVRLVVLSRQDPIKWVLLVLPFYHALTAEILALFMVLGGGHGVPSSTTEVPADPCGITHGVFAGVTALTCCVLLLTQGCQLPRLLQRSLIDTAWPRKTAASDSGTPMALFPACYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2R3</accession>
    <name>B0Y2R3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_051670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2R3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051670"/>
    <dbReference type="HOGENOM" id="CLU_000288_17_3_1"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
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            <dbReference type="ARBA" id="ARBA00048367"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP51165.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1092" mass="124549" checksum="C0918C5D43CF2AA6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y319</accession>
    <name>B0Y319_ASPFC</name>
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        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </reference>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="413" mass="46803" checksum="37001AC5318D2115" modified="2008-04-08" version="1">MSLSPRELFAISTTERICSAISLAGTSIIIISFLSSRSFRKPINRLVFYASWGNIMANVATMISQSGIAYGTSSCLCQFQAFLIQWFMPADALWTLAMACNVYLTFFHKYNSEQLRQLEWKYVLFCYGLPFIPAFVYFFIETEARGKVYGSAILWCWVSLPWDFLRIAVFYGPVWFVIFLTFAIYLRAGKVIFEKRRQLEEAECPESSGEIDSPMEPAVSKKTEIHVTSEITHSGSESNRLSIMSASLIPHRYLSPYSPYSVTIEGGSAAGNDEHVPMRTLRSSQHDPYAQHHAMARDVNSAAWAYTKYAMLFFIALLVTWVPSTINRLYALIYPRNFNFGMNYTSSFVLPLQGFWNSIIYVSISWPAFKEAFAKIKWRHSLQRGPSQHIITGHGAVGSLHSHGNDSTRALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3P5</accession>
    <name>B0Y3P5_ASPFC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_000288_57_9_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="515" mass="54232" checksum="15F5C194830C4386" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3X6</accession>
    <name>B0Y3X6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_055770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055770"/>
    <dbReference type="HOGENOM" id="CLU_1864659_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="137" mass="15194" checksum="D2352391CEF5BD72" modified="2008-04-08" version="1">MILSIPCSPSPSSSVINTEGSLSLSPLPSPSLDAAQCRPNFWRIFPTSLDGRYGLDFVNVAQTSKILCGLRLYFSSVWRLPGYYYYQGFCSGNIHGPGKTSVTSWDSLALFSLFFLFPHPRPPYCFLLSPFLGPCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y413</accession>
    <name>B0Y413_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ThiF domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_056150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y413"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056150"/>
    <dbReference type="HOGENOM" id="CLU_013325_9_3_1"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="PhylomeDB" id="B0Y413"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="104"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="513" mass="56434" checksum="445ADC1E08535D7A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4L0</accession>
    <name>B0Y4L0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_069460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4L0"/>
    <dbReference type="HOGENOM" id="CLU_1194652_0_0_1"/>
    <dbReference type="OrthoDB" id="5419608at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760702" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="25698" checksum="7253E7E2DBA738D0" modified="2008-04-08" version="1">MQYKTLPLLLLAATALAAPEARPEAAAEAAPEAAPEAAPYDYYSSLMNELNSLADTSNWDKFLTNIDYNQYLTNTDYKQYLTNTDFGGIPTNTAADNVPTNTKLGGVPTDLEGLPSFSMPTAAFTYDGMPPPSIASVLITAVPSSYMSQLANPSARSSLINDIQHGHYPSWYNDLPNSVKQWISTNYASMTGAAATATGNSGSGSGSKGSDSQGPASSSSSQGAAAAPAATGAIAASIVGAAGVLGIALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4U7</accession>
    <name>B0Y4U7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Chromatin remodeling complex subunit (Chd3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_070360</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055565">
        <property type="entry name" value="DUF7141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040934">
        <property type="entry name" value="Znf-CCCH_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18585">
        <property type="entry name" value="zf-CCCH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="303"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="475"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="685"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="993"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="147"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1283"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1460"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1284"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1297"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1460"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1491"/>
            <end position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP50696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1509" mass="170757" checksum="7C57585EBAB310CF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4W4</accession>
    <name>B0Y4W4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_070530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4W4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070530"/>
    <dbReference type="HOGENOM" id="CLU_2291066_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="101" mass="10922" checksum="C130671AAC900278" modified="2008-04-08" version="1">MDCIQVVSSLSYADLNRKITETGFRSGRLDFAGVGGLQNELIGLIQDLEALTGKRCLETYGGEVVQNRPDIWADCRIFPRKAASLSVDGQVFISTSPEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y588</accession>
    <name>B0Y588_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Toxin biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_071770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y588"/>
    <dbReference type="SMR" id="B0Y588"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071770"/>
    <dbReference type="HOGENOM" id="CLU_090039_1_0_1"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000680">
        <property type="entry name" value="AflX/ ordB/ monooxygenase/ oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF37">
        <property type="entry name" value="OXIDOREDUCTASE MDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="263" mass="29017" checksum="FBA39712BD3CE684" modified="2008-04-08" version="1">MPYAVLGATGNCGTALIQNLLQSSTSKVHAYCRDRRKLLYLLPHLADNKQVDIFDGSIHDLPLITECVRNCHAVFLVISTNDNVPQCRMALDTATAVIQALRILHGEGASMPKLVLLSSATLDDQLSQNTAPWVRWILLKSASQVYQDLSQAEAFLRQQQDWISTIFIKPGGLSVDVQRGHRLSLTEEKSPLSYLDLAAAMIEAADDPDGRYDLRNVGVAYTDGPARFPRGAPMCIFMGLVRHFLPFLHPYLPATGPNQGFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5K3</accession>
    <name>B0Y5K3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_063690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5K3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063690"/>
    <dbReference type="HOGENOM" id="CLU_079969_0_0_1"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5K3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24721" checksum="A09F5A6076755392" modified="2008-04-08" version="1">MASAQHFEPDTIINLSGSSQEAAHGTIDIFEWYPHYQSCQRYFLDHAQHSVTVQALCAFLNIRLPFQRIPHPVSSSSSKTSTPSAGLTSSVSESSPHPAPFVSLIPYIRRLVATGMDSPGVLQGFFGYDWTAGVGYLHEQERRNYLFAAKSGGWAAVKRDYDMPPLETIPFLRPLQGTVDSEIEAAERSWSEWLAMEDWMVGPRAPDALRGSSSHMSCPRSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5L0</accession>
    <name>B0Y5L0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_063760</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063760"/>
    <dbReference type="HOGENOM" id="CLU_000404_1_2_1"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5L0"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
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    </dbReference>
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        <property type="entry name" value="Rrm1"/>
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        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
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        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
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    <dbReference type="PROSITE" id="PS51161">
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    </dbReference>
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        <property type="entry name" value="RIBORED_LARGE"/>
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    </dbReference>
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    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="783"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP50045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="859" mass="96107" checksum="C7F3D27FB750E32B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5M5</accession>
    <name>B0Y5M5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch DNA repair protein (Drt111), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_063910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_025002_1_0_1"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000495">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="534" mass="58071" checksum="964C5CB8539BAF26" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5R2</accession>
    <name>B0Y5R2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-rRNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_064290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5R2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064290"/>
    <dbReference type="HOGENOM" id="CLU_006918_0_0_1"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5R2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="3">
        <location>
            <begin position="471"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="4">
        <location>
            <begin position="595"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="5">
        <location>
            <begin position="691"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="84452" checksum="E55EEEA5A60B427F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5S6</accession>
    <name>B0Y5S6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ubiquitin fusion degradation protein UfdB, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_064430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5S6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064430"/>
    <dbReference type="HOGENOM" id="CLU_003224_0_1_1"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5S6"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="996"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP50111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1088" mass="124162" checksum="78601B473EB60252" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y603</accession>
    <name>B0Y603_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_065200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y603"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065200"/>
    <dbReference type="HOGENOM" id="CLU_029375_3_0_1"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="PhylomeDB" id="B0Y603"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="135"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="415" mass="45587" checksum="02D664434736644E" modified="2008-04-08" version="1">MVELQPIFKKAYWTLAAGGLVYVSFVCALTWPNVQRFALYANKVNPALWEDVNQVERFGFLKTQVQPFNLVTPDNETIYGWHLLPLHLCREHEEELNANEPSGPADDYTQTPAFKFLAHDPNARVVVNFHGNAAHLGSAQRPEIYRMLLGLSSPSNPVHVFAIDYRGFGVSTGSPTEEGLITDGVSLINFLTAGPLNIPPSRIVIAGQSLGTAVSAAVAERYAFGSPDPAAVQPAINDPEPFAGVVLLASFSNMRNLIESYSFKGLTPPMLSPLIGYPRVQRWVRSHIVDHWDTAARLARLTGVGPSAEEDAKAGYNSKNLDLAIIHAFNDVEIPWYEGRSVWIAATGENQKDAPGTLAYQKKEEGGPTEVKIWENRSGKHAVKTVRWERVGYGGHNRVATFSVAALAVLRAFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y683</accession>
    <name>B0Y683_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_066010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y683"/>
    <dbReference type="HOGENOM" id="CLU_048466_1_0_1"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="PhylomeDB" id="B0Y683"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="MAT1 centre" evidence="7">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="337" mass="38234" checksum="55FEC0459A05FA2D" modified="2008-04-08" version="1">MCESCVDRIFSSGPANCPVAGCHRTLRKNRFRKQTFEDIGVEREVDIRRRVMSILNRREEEFDSKRAWDDFLEQREEIIANLVHGTDVAKTEADLQKYAQENMNSIRANRALEVQEATSFQEQQTQEQELARIRREEARQEYENERREVIAGREDYLARLASGKPGDAATIARESHKVLLKKSSARRSEEERIRQKQAALRSSELKKLGQAATTADRAGPADTGLIKGLKKIKTPEPEKAYDPFGGFIPNKRDYYTLRDHYPSSYLDPIRQDTRMQAGGYDLREYYSRTLLEAFAGLGCFIDEEVSKRDATSKLANAKPVATEGAAMAAVSSSKVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y742</accession>
    <name>B0Y742_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_072490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y742"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072490"/>
    <dbReference type="HOGENOM" id="CLU_011027_0_1_1"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="PhylomeDB" id="B0Y742"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="717" mass="78549" checksum="62188E169DE5AEB4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y776</accession>
    <name>B0Y776_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho GTPase Rho1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_072830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y776"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072830"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="B0Y776"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="200" mass="22530" checksum="D4744B5AE9EFB9BA" modified="2008-04-08" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAIDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKKDLRHDPKTIEELHKTSQKPVTPEQIIDIFVQGEEVRKKIGAYKYLECSARTNEGVREVFEAATRAALLTKTHKKKGKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7P2</accession>
    <name>B0Y7P2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_074500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7P2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074500"/>
    <dbReference type="HOGENOM" id="CLU_103811_0_0_1"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="233" mass="24842" checksum="E5AA08F0EA794226" modified="2008-04-08" version="1">MSHQAPPRPFRPIAPRTALDTPPAGPVAEECKVRRASTACRECQRRRTKCSANSTGAPCSECALHGRDCIVDEYADKRRKVARDRIQEELAYYREFVQQLLAAIRHGNRTDVDVIINVIRSGASLEKIHLIVAQSLSHTNEADGLEIRVCDPNKEPDGISGNSSPDAKEPDGISGNSSPDAKEPDGVSGNSSPDAKEPDGVSAEASPVVNEPNGGPLESSPDAGLSAILNNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8H5</accession>
    <name>B0Y8H5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxisomal AMP binding enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_077360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8H5"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8H5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF15">
        <property type="entry name" value="AMP BINDING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="435"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="58362" checksum="897CD9D460F56468" modified="2008-04-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y904</accession>
    <name>B0Y904_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_079180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758298" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="3">
        <location>
            <begin position="638"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="875"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1254" mass="138447" checksum="86AD85DDDABB0D51" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y996</accession>
    <name>B0Y996_ASPFC</name>
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        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_080240</name>
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    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="PhylomeDB" id="B0Y996"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="17"/>
    </dbReference>
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        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="358"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="839"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="873"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="941"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="976"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1147"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1216"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1250"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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            <end position="1308"/>
        </location>
    </feature>
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        <location>
            <begin position="1318"/>
            <end position="1342"/>
        </location>
    </feature>
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        <location>
            <begin position="1352"/>
            <end position="1376"/>
        </location>
    </feature>
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        <location>
            <begin position="1386"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1508" mass="168356" checksum="CD81F0027C654837" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9H7</accession>
    <name>B0Y9H7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_081080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
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    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
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        <property type="protein sequence ID" value="EDP48670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="B0Y9H7"/>
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    <dbReference type="HOGENOM" id="CLU_025300_4_0_1"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9H7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:vesicle membrane"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF179">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="464" mass="50929" checksum="DD92C253803B4CE1" modified="2008-04-08" version="1">MSHPQYTYGGPPQPPYNSAGYGQPGAHQQQPAPFYPPQQPGGYPPQGAPPQQFPPSGQYQQPYGAPPPQQQWPGQPPQQYPQGGHPPPQQYPPQGAYPQNQYPPQGQYPPHGQYPPQGGYPPQGQPGYPPPQAPQPMPTPPSLGYDPNQRAPGDATREAEALRKAMKGFGTDEKALINILTKPDPLQMALIRHTYTDRIGRNLEKDLKSELSGDLEDVLLSLARGPLEQDVATLRGAMSGLGTNENLLTDVLVGRSNADLRAIKYAYVSKYQKSLVEDIKSDLSGKTEQFFVMLLNATRPEPGTYFDAQSVDADVREIHQATQARKGTDEIGVFAVLLGASDAKLVAIAQAFEAKYHISLEKVIKDEFSGHLEDALLSMLSKAKDPVGHDVEKLLKCLPPVENGKADVKRLIYWVVHLHWNPPHFAAVKARLKQKLGHDVGNHFREAIAPGDFLTAMRQVWNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9N2</accession>
    <name>B0Y9N2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloalkanoic acid dehalogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_081670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081670"/>
    <dbReference type="HOGENOM" id="CLU_045011_2_0_1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9N2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="242" mass="26603" checksum="E3D6F8F991EEF509" modified="2008-04-08" version="1">MPTKHIIFDVVGTCVSFDAYFASIAATIGPKLSSHGITPTHFGYTWMTAAELEFTFLSISESYRPYKDVMRALFYRSLFMAGVAQPRRVFTEEERDACLAGYASLQLRPELVPALEKLRSAGFEVWCLTTGDVERVRGYFTRAGVEMPVERVLSCDGLRVAKPAPGAYRAAIETIGSGGEDEKWFAAAHLWDVSAAVRAGFRGAYCGVLEGEGCWEVFERESLEVVAEGLVEMVEGVIQLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAA3</accession>
    <name>B0YAA3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_083950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAA3"/>
    <dbReference type="HOGENOM" id="CLU_007091_2_0_1"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="PhylomeDB" id="B0YAA3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="684" mass="76918" checksum="6D164BC5E65FBF95" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAT9</accession>
    <name>B0YAT9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_085810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085810"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="PhylomeDB" id="B0YAT9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="498" mass="56928" checksum="BA19F8F377687F8A" modified="2008-04-08" version="1">MPTRDAHLQLQKWAQEYGPVYSLILGTKPLIVLSSDQAVKALLDKRSALYSHRQEMYIGQTLCSGGLRMLMMCAGSADPRRDTPQSGEEFQFRKMVHGLLNVTAAKSYVPYQMLENKQMMYEFLTQPERFLYSIRRYSNALTTTMVFGWRTPTYEDAKMKQLFDGFSEFAEINQTGTAALIDFFPWLRMLPDFLLPTQKRAKELHEREKALYLGHYLRAKQDIRDGQIKPCFCVGLAEAQKSDGFSDDQAAYISGTLLEAGSDTTSNTLYAFVQAMLLFPDVQRKLQEEIDRVVGPRMPTMDDEQDLQYVRACMKETLRWMPTTILGAVPHAVTQDDEYMGYLIPKGAGVVNNVWAIHMDEKRHPNPRVFNPDRYKDDRQSLAEAAANPDATKRDQFTFGAGRRICPGIHIAERSLFLGISRMMWAFNVEPAVDEKGQPILPDPDRLTQGFVCMPEEFPARITPRSQAKADMVIKEWKEAEQQCLDPETKQWLLSPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBY1</accession>
    <name>B0YBY1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_088220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088220"/>
    <dbReference type="HOGENOM" id="CLU_008719_1_0_1"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="PhylomeDB" id="B0YBY1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57981" checksum="5B70FAD9364E401E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCF1</accession>
    <name>B0YCF1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_089970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089970"/>
    <dbReference type="HOGENOM" id="CLU_046315_1_0_1"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="PhylomeDB" id="B0YCF1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="501" mass="54720" checksum="9012E4129B375579" modified="2008-04-08" version="1">MVSSFCWSCLTRLRPTTRALLPPTLATPRVAAFHSSSVQYANPTKKKVSLDGPPKYRQAKSAKMKKKKPVDRPRPPPVGERKALRKRIVLSNPNALEVQGMQDLTEETMVDSRLRGTVLGLPLPLIDPLRAVQAFKPKQGWSIFRRPGTVVRRETVELGRQFDMISGEGEDKGKVVKKIVTGVRGAGKSVHLLQAMAMAFTKKWVVFTVPEPQDLVIAHTGYAPLSDEAPNLYVQNEATAALLSRTVKANEEVLSGLKVSRAHPAFGSAVKPSTSLAELATLGINDPAVAWPVFEALWAELTATSASPGYDMAFKTRPPILATVDGLAHWMKNTEYRSADFEPIHAHDLVFVRHFLSLLKPGAGQPTLPNGGMLLYATSASNNPTVYSFEVALKQVAARQAGLNPSAPEFPQADPYSKVDKRVLDAFDSPKPSSAKEGALELQTIGGLTRDEARGFMEYFARSGLLRENINDEWVGEKWSLAGGGIVGELEKLGRRLRVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCL7</accession>
    <name>B0YCL7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_090640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090640"/>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="PhylomeDB" id="B0YCL7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="483" mass="51310" checksum="3638EDA99076FC84" modified="2008-04-08" version="1">MASPPPVIIAGSGLAGLSAASTLIAHHVPVLMLDRALKPGGNSIKASSGINGAGTRFQHCDDNADIFFQDTLRSAGQAFTRASSDERARRETLISTLASRSADAVHWLVDEKGVDLSKVAPLGGHSFPRTHRGAGRDPPGFSIVGTLLRKLKMEGLFTLRNGARVTRVVKEEGCVKGVEYVTVEGETQNHTVKGPVIFATGGFAGDSSGMLAQYRPDLADFPSTNEAREGTQPILEAVGASVVDMECVQVHPTGFVDPKDPAAMAKFLAAEMLRGEGGILLNSDGSRFVNELETRQHVVDAIRQSTSPMETATRQWDVTLVLDESSAAAAGSHMDFYVAKGLMKKVTVGGLDLPTVKTLQEYGDVVSGRKEDPFGRKSFGHWKLTEVLPEYAVYVGQVTPVIHFTMGGVVIDERSRVIGTDGTPIEGLWAAGEVTGGVHGQNRLGGSSLLECVVFGRIAGTEAAAWHKEHYPEAPPSSDGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCL9</accession>
    <name>B0YCL9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_090660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090660"/>
    <dbReference type="HOGENOM" id="CLU_028269_1_0_1"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="PhylomeDB" id="B0YCL9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF2">
        <property type="entry name" value="DUF2264 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="14"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="409"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="77672" checksum="42BA2C6D22A09C46" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCR3</accession>
    <name>B0YCR3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEAD/DEAH box helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_091110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091110"/>
    <dbReference type="HOGENOM" id="CLU_014765_0_0_1"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="PhylomeDB" id="B0YCR3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="74"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="292"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="690" mass="77955" checksum="7FD6872440CFFB9C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCR5</accession>
    <name>B0YCR5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_092930</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCR5"/>
    <dbReference type="SMR" id="B0YCR5"/>
    <dbReference type="MEROPS" id="A01.081"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092930"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PhylomeDB" id="B0YCR5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000068">
        <property type="entry name" value="Aspartic-type endopeptidase (OpsB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760848" description="Probable aspartic-type endopeptidase OPSB" evidence="17">
        <location>
            <begin position="21"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="18">
        <location>
            <begin position="69"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP47449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="485" mass="51337" checksum="368E316BAE0BFCE2" modified="2008-04-08" version="1">MRHIFSLLSIVCLMVKHGACLTLHQRDVPAVVSLDIKRSIVSDPVVRDRVRRKRDKTIGQTLDNAETLYFCNVTLGTPGQALRLVLDTGSSDLWCNAANSTLCSDSNDSCNISGSYDPSSSSTYAYVSSDFNISYADGTGAVGDYATDILHIGGSTLRNLQFGIGYSSTSSEGVLGIGYPSNEVQVGQYGKDTYPNLPRAMVDQGLINSNAYSLWLNDLESNTGSILFGGVNTGKYLGELQTLPIQKVNGRYSEFVIALTGVAFDSESHHKTYSSDALPAAVLLDSGSSLTYLPDSIVENIYRDLNVAYEPSSGVGYLPCKLAGNNINITYTFSSPNITVMIDELLLDAGDLRFRDGARACIFGIVPAGDSTAVLGDTFLRSAYVVYDIANNEISIANTNFNSTEDNILEIGVGPDSVPSATQVSHPVTSVVADGSGARIGAPTGASSTTVPSISSAGALSAGVARADKQYLAIALIAVWFVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCW0</accession>
    <name>B0YCW0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_093380</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCW0"/>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_1"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="PhylomeDB" id="B0YCW0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000072">
        <property type="entry name" value="Leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.590:FF:000002">
        <property type="entry name" value="Leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000285">
        <property type="entry name" value="Leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="82"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="14">
        <location>
            <begin position="269"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="486"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="795"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP47494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="988" mass="110760" checksum="37A31A8F9A0A2917" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD62</accession>
    <name>B0YD62_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_094410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094410"/>
    <dbReference type="HOGENOM" id="CLU_2164290_0_0_1"/>
    <dbReference type="OrthoDB" id="4502957at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="111" mass="11785" checksum="4FCAB3E5610DD939" modified="2008-04-08" version="1">MARADIDNRSPLQAEAKRNFENQIVLSPSSHNASVALGARTRVLRASDVLLSLAGKTEKETLGDEDSPGVESFAETVRLFPPLTNDDGAPNGAVDSKCPDCDAVFSSPYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDA4</accession>
    <name>B0YDA4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fructosyl amino acid oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_094850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094850"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="PhylomeDB" id="B0YDA4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="497" mass="54943" checksum="034710914335AD73" modified="2008-04-08" version="1">MSIPNSFIIVGSGVFGLSLAYALSLDDRFADKKIILVDRWNFEPPNATGSVHNPAAANADTSRVIRRDYPHGPYASLALEAMKHWRGKFGENNRYVNQRLLFSGEGSSLTTPPKALETVNYIKKAYAISCELTPGGRDAVQVLDSLDEVRAFLGNTPSHPPHLPVNKDPAARDLRGYISNDCGWADAGASIEWLRQEVLRLGRVECVVGEVESLVYSDDQRAVKGVKLVDGKVLTAELTVIAAGARSSHILGIPKLCDVYSEFVAYIQLTKEEADELRRRQWPILVNCHRGVFAVGPDHDNCLKFGHFSYSGIVDVLREASIQVPTRPDGWEAQQKYWSDPRFAFGGEVKVSALGDVDDYENPAAQRALADYRLFLLELLGPTGLQGVDTLGLDQSDNLLNNIANRPFTRVRKCWYNDTPALDFVVDYHPSYGKTLFVATGGCDHAFKFLPIIGEKTLALILRNRGDSAVSLPAGVEPSLEELSELWRFPVELLQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDG7</accession>
    <name>B0YDG7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_095520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDG7"/>
    <dbReference type="SMR" id="B0YDG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095520"/>
    <dbReference type="HOGENOM" id="CLU_049413_3_8_1"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="PhylomeDB" id="B0YDG7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP47701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="241" mass="26835" checksum="329D4F3F46BAB60D" modified="2008-04-08" version="1">MAPPRAPYIVPALKKHTATVIMAHGLGDRMSLAQNWRRRGMFDEVAFIFPNAPMIPITVNFGMTMPGWHDLTKLGRELDYESAIRHQDEPGVLRSRDYFNTLIKEQIDKGIKPSRIVLGGFSQGAAISVFTGITCKEKLGGVFGLSSYLVLSDKLKNYIPENWPNKKTPFFLAHGLEDEIVLFDFGDLSAKKMKEIGLEDVTFKSYPNLGHSADPVEIEDLARFLQKVIPPEDDGQASAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDL1</accession>
    <name>B0YDL1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARP2/3 complex 20 kDa subunit (p20-ARC), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_095970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095970"/>
    <dbReference type="HOGENOM" id="CLU_2412838_0_0_1"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="92" mass="10469" checksum="D004B2FC8CA98884" modified="2008-04-08" version="1">MLKHKLVDFIIQFMEEVDKEISEMKLFLNARARFVAESFLTPVRDYSLLSSPASFLMNPRYSLTKKSLTLPTSFLELTSVSNENLCTGDLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDW0</accession>
    <name>B0YDW0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDW0"/>
    <dbReference type="HOGENOM" id="CLU_530977_0_0_1"/>
    <dbReference type="OrthoDB" id="2103397at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="513" mass="57458" checksum="2E144ADDB0492C7B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDZ6</accession>
    <name>B0YDZ6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_097337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097337"/>
    <dbReference type="HOGENOM" id="CLU_1460966_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="185" mass="21219" checksum="B5BB76CF3BF35D6C" modified="2008-04-08" version="1">MIYACTFPNCWGRCTLRSSFTATCQTISTSEYCRTRITSIIVWDTLCLSALSQIVSKEPRCYFFSQIAEEPCCNTLRTKEQLGYIANSAVVVYVMAGTWRILLPCTLTNSIDQISTVYHDVEHIEPFTKKDIHEFPNQDIHPTSPVAQSCLYILLHGHLLELLEETELQLKKILTLQCWMKIKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF01</accession>
    <name>B0YF01_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynamin GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_101090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101090"/>
    <dbReference type="HOGENOM" id="CLU_008964_7_3_1"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="PhylomeDB" id="B0YF01"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="3">
        <location>
            <begin position="107"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="697" mass="78930" checksum="82C09C9D5AEA9EB3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF46</accession>
    <name>B0YF46_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_101540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101540"/>
    <dbReference type="HOGENOM" id="CLU_138695_0_0_1"/>
    <dbReference type="OrthoDB" id="4440815at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760890" evidence="1">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="90" mass="9453" checksum="853B63B239B857D6" modified="2008-04-08" version="1">MKPTLFVLALAGVALGAKTCTPSFDYCAKKLIADKGFTEADLEVVLKAEDLETTDLKNVLFHCKNPGDVGHAKVCPNGCTDPATEGSHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF78</accession>
    <name>B0YF78_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter of unkown specificity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_101840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101840"/>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="PhylomeDB" id="B0YF78"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000884">
        <property type="entry name" value="MFS transporter of unkown specificity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000899">
        <property type="entry name" value="MFS transporter of unkown specificity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="533" mass="56990" checksum="B64AD753574C03BB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XLZ6</accession>
    <name>B0XLZ6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_001560</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000626_1_0_1"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="PhylomeDB" id="B0XLZ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM46</accession>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
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                <person name="Sundaram J.P."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13370" checksum="85AD7112A44C61CF" modified="2008-04-08" version="1">MSLSTTSTPLNATSIGWLLISIGHTISARDWQSLPQFSKLPTLAYTCAKAGWYQGSAFFLMTAMINYNWAQNPALLAEPINKGIAALMTAIVWVSAAWYLKKGVKTNGVAVAAMGALQAWAAFR</sequence>
</entry>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    <sequence length="647" mass="71955" checksum="3F2F25A11283632E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMP9</accession>
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        <submittedName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013730"/>
    <dbReference type="HOGENOM" id="CLU_083147_2_4_1"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="PhylomeDB" id="B0XMP9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="143" mass="16195" checksum="0C1D163B0757D68C" modified="2008-04-08" version="1">MDTKSPEQPAPAAPHAHEWSSSFWDCFSPTETCLIGWCAPCCLFGKTQSRLQDPALKEHQYVNGDCCLYALSSYCGLYWVLLMIKRGQLRERFGIQGSTFQDCWQSYLCPCCTLVQNEKEVEARFSNTTQVGYQPPSGMAYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMR9</accession>
    <name>B0XMR9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydroxyisocaproate dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_013940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013940"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="PhylomeDB" id="B0XMR9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="31"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="119"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="335" mass="36534" checksum="816400FEEC185882" modified="2008-04-08" version="1">MPSALLIGAITHARKEWKDLSSILTLKEFPEGTRDEFIRNCKDGQYDDVVVIYRSNASTKFTGPFDAELLSVLPKSLKYICHNGAGYDNIDIPACSEKGIAVSSTPVAVNHATADVGIFLMIGALRQAYIPLSALRAGQWQGKTTLGHDPQGKVLGILGMGGIGREMANRARAFGMKIQYHNRSRLSPELEGDAQYVSFDELLANADVLSLNLALNAKTRHIIGEKEFQKMKDGVVIVNTARGALIDEKALVAALDSGKVMSAGLDVYENEPEIEPGLVNNPRVMLLPHIGTATYETQKEMELLVLNNLRSAVEKGEMITLVPEQKDIFKGQNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN68</accession>
    <name>B0XN68_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_014770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014770"/>
    <dbReference type="HOGENOM" id="CLU_108992_0_0_1"/>
    <dbReference type="OrthoDB" id="5407417at2759"/>
    <dbReference type="PhylomeDB" id="B0XN68"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17017" checksum="3F130EBD51AEEE76" modified="2008-04-08" version="1">MTTAQPVAPQTELVTPAYKPQEISFPLPKALHTTAHVHLTILETCVTIFLATTTPGEPGGSLKPMGSFIYAMPDRHSPRSVISTVLYSSPSTEEYTSRVAKILARRMSLPVYVGCSIDPRALELAVEEEMEGLSKLVEVIMDRWEKTKSQSKITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNE2</accession>
    <name>B0XNE2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_004630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004630"/>
    <dbReference type="HOGENOM" id="CLU_059402_0_2_1"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="267" mass="29710" checksum="B007CE949A95C371" modified="2008-04-08" version="1">MSDQENNSRPSSPTPNPTQTEEGAPPTPKTDTQTPTKKPPKLGKKKQQQQQESKPQPEPEPAEPEQQEENEENPPDNTKEDPRPQRDTHDVSANGEATEEDQEPEQPQPQQEQPRPRRRKPQPQRYRPDSDTESIPRPEMDNNTAMEKPRRRRQRPQMQQQQQQQDGGPLGGLGGVNQVGDLVQNTAGNAVNGVTGSAGKAVGGLLGGNKGEKEDGGRDEQLRLRLDLNLDIEVQLKAKIHGDLTLGLLYVFFRLFPYPDGMIKCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNJ0</accession>
    <name>B0XNJ0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="4 15">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_015320</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="4 15"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNJ0"/>
    <dbReference type="HOGENOM" id="CLU_067602_0_1_1"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="PhylomeDB" id="B0XNJ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP56812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="255" mass="28274" checksum="DADED2CCEB74CBF1" modified="2008-04-08" version="1">MSARTRRQKAALAAQSEDSDVTTTSNGTTRKPPQKNSSPSPDAEARENVFLFIPNLIARYYNQSTTFGAVLDMVTDRCTTACLLVFLSSAWPRWAILFQSLISLDLASHYMHMYATLSMGGASQSHKNVEATRSWILYQYYHSKTVLFICCALNELFFIGLYLLSFSSPILSPSLLQAQDPSAPPALASPWSAGALELARANKIDSFWPWVITGISAPVMALKQFINVVQLVKASKWLAEGDRARRKAEREGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPH5</accession>
    <name>B0XPH5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_006500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006500"/>
    <dbReference type="HOGENOM" id="CLU_040831_0_0_1"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="472" mass="53572" checksum="0ECEFD2C1BF154A7" modified="2008-04-08" version="1">MEAIYGFDRMSIDEPAPEAPAEAPAEEPVVIRPCAYCSEDIEGEQVRPCKECGCYCCTECIRQIFLMACKDEAQMPPRCCQPIPLAVARRHLSDEEIALYKLKFEEWRTVNRCYCPVSTCSGFIPPSYIQQQWKNLVASSGFYRQLAASGATPSLPVSPLYISFPVLCPKCFAQVCWKCKKLYHHGSTCQASDIDPELAQTLQNLGIKRCPKCRAAVRRMLGCRHMQCRCGAQWCWYCCRAIEVCKANICDKGREAEIDVHEDNAEEIATQVDEGEAKEEEDEDEDAEGDSDDEAYWSRYGGWISDPDETDDEQNDQAAYEDDDNKNQAPEMPLARPVEHNHFAAEAGSDVDLDARSDWEEDSDIFGTEPDGSRLDPFDCNHDFAMIIDNSEVENSEYEYECENCWRRIFPRETLIPGSLWEQIQSEDTSPTAQLIASMTVVERSDAQMYLCRNCKFRLCGPCRAGYGNFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPN9</accession>
    <name>B0XPN9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SDS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein sds23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_007050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SDS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007050"/>
    <dbReference type="HOGENOM" id="CLU_024459_0_0_1"/>
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    <dbReference type="PhylomeDB" id="B0XPN9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="274"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="387"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="538" mass="57864" checksum="1F19FEDB22D7A1CA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ71</accession>
    <name>B0XQ71_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_008940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ71"/>
    <dbReference type="HOGENOM" id="CLU_012062_23_3_1"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ71"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="215" mass="23610" checksum="77526E705E7E7649" modified="2008-04-08" version="1">MATEEQEVKDERLETHEEGGDDEVSRAGAEAGDGALTPTSHFYATLHMEEIAAMKRRVAEMESEAAKLREMQATLDQQSESLREDKEEIDARSIFVGNVDYGASPEEIQAHFQSCGSINRVTILLDKFTGQPKGYAYVEFAEPSLVAQALVLNESVFRGRNLKVVPKRTNLPGMSSRGRGRGGFRGGRGFYRGGFPPRGGYRGGGRGRGRGYAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ95</accession>
    <name>B0XQ95_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAP2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_009180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009180"/>
    <dbReference type="HOGENOM" id="CLU_021458_2_0_1"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ95"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000042">
        <property type="entry name" value="PAP2 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="108"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="353" mass="39486" checksum="D08650AF4C5E5C3D" modified="2008-04-08" version="1">MRPALSRIPLRLVFSYILDWIFIVIVAVIGFGFHKVQPNHRPFSLTDPSISFPYTEHETVSTAVLMVVALIAPAVIIVITALLIPMSTKDQNVPRSSLWRYKLWEWNAGWMGLAVACAWAWMATEGLKDLYGRPRPDMLARCNPDLSNIATYAVGGLGENLAGAPTMVTWKICQNKSKVLANDGFASFPSGHSSFSFAGLTYLTLWLCSKLSIAFPYLGHSLLNQNPIGPINGSIRKRGAAPPVYMLVVAFVPIAVASFIGASRWFDYRHHAFDILFGSIMGAIFAWIGFRMYHLPITRGEGWSWAARSRRHAFFKSPRFPSEADERRPIDTHDTQKTTRQDIDVERAAENLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR02</accession>
    <name>B0XR02_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl CoA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_011770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011770"/>
    <dbReference type="HOGENOM" id="CLU_043304_1_1_1"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="PhylomeDB" id="B0XR02"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="401" mass="46045" checksum="A59EBC555332442B" modified="2008-04-08" version="1">MSDSVDRVFVHALNTVKRIPRTGTARPPAAERLKLYGLYKQSMEGDVEGVMDRPVGNTADVYAECEKWDAWYAQRGLSRTEAKRRYISTLIDTMHRYASQTPEARELVAELEFVWDQIKSNTSSSSSSSPMQNVGVPPLPQPNYASIGGRLARPIYEDIIATARDNHSRERNHGDSRLRVLSPVSQPDGLYERRGNKDMGDEEAQVLEDEDEEDEDEEEYEEAQDTIYEDDDDNDDDDDNNNNNSNSNSNSQSQENSHRFDDDPDEAQSRGRTRGLQPATAAGDKKHRVVSSGERDRRWRRRVEQALTKMTAEIAAVREQMEARALASRRRSALWTWLKWIVWVTLRQIIFDLAILGMVLIWMRIKGDRRLEEKLKVGWSEVKTRLAKLKSLRRFPGLDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRB9</accession>
    <name>B0XRB9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconate dehydrogenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_012810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012810"/>
    <dbReference type="HOGENOM" id="CLU_035117_5_0_1"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="PhylomeDB" id="B0XRB9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="4">
        <location>
            <begin position="238"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="40290" checksum="4D9445AB4F8CD237" modified="2008-04-08" version="1">MPSRDRGRPVIPRINKYIYPHPILFTSAQEPHSQFTAQNQDESDWLGKSSPDQTNLDSQHSNDLNQYGLGSMGLAMATNLQRHLATKGALNLVYSNRTMARGDTLKRLGAVPEPSFPNLVAQCGIIFTMTTQISNDTVLSNLITTAVESGHSLKDKIFVDCSTVHPQTVGLTVSKLKEKQASFLAAPVFGGNPIAVDGKLVFAIGGPRSAAEVVKPLIQDVMGRKIIDCGEDATKSSLLKIAGNIVTVNLMEAVGEAQVFAERTGLGTGPMEELIGEAFGAVAGGYSKRLTSGAYAPSLDSRPGFGVSLAIKDANHALAIANEQNVRLPGLQVARENMMAAREYAGECLDSSSMYGVLRQQAGLEFWNEKSRKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRT7</accession>
    <name>B0XRT7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_024790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRT7"/>
    <dbReference type="HOGENOM" id="CLU_117263_2_0_1"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="PhylomeDB" id="B0XRT7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP54423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14095" checksum="90D5742E2CDF94E0" modified="2008-04-08" version="1">MDSQPSSKALHNRINANISQLLQRFENIMATATVPVAQWLTSVSQVENTSHTATAVETYQLDVESTALVRAAEDILSLTRTMKEAWLFGKLDTLGEDEADVKRREQLESNAEAIQRAIAEGGLLKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRX2</accession>
    <name>B0XRX2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_025140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRX2"/>
    <dbReference type="HOGENOM" id="CLU_002786_0_0_1"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF4">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="970"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125108" checksum="38AAD60F3E8BFFE3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRY8</accession>
    <name>B0XRY8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl xylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_025300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025300"/>
    <dbReference type="HOGENOM" id="CLU_2704370_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="73" mass="8176" checksum="CF8B5115260ECCBD" modified="2008-04-08" version="1">MGRLCRSSISSQVMHPLQVLTPNGSAPPNCNETVETCMQWVGIFGYKYDALKSVVENTPDDKYENHLRVTSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSH2</accession>
    <name>B0XSH2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proteasome component Pup2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_027180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027180"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="PhylomeDB" id="B0XSH2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 7 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="250" mass="27329" checksum="5A50E93D3B653DC0" modified="2008-04-08" version="1">MFIARSEYALPIDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATSEGVILGVEKRVTSTLLEASSVEKIVEIDQHIGCAMSGLQADARSLIEHARVECQNHAFHYAEPLRVESTTQAICDLALRFGETGDDDESVMSRPFGVALLIAGYDEDGPQLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHRSLTLPEAETLVLKTLKQVMEEKLDAKNVQLASVTKEKGFHIYNDEEMGRAVAQLGGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSK4</accession>
    <name>B0XSK4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_027510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027510"/>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="PhylomeDB" id="B0XSK4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="5"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="769"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="859"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="914"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="930"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="976" mass="108269" checksum="8E3DF01D76CFD61D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSL6</accession>
    <name>B0XSL6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_027630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027630"/>
    <dbReference type="HOGENOM" id="CLU_2687343_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="74" mass="8496" checksum="78C8CF782C976D7A" modified="2008-04-08" version="1">MAQNENIANRKKQETIKKTVKPSRASWPNHLIYTMQTNTKFCQLPTTAALKKSQWVCFHADNRVVPDIPGTLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSL9</accession>
    <name>B0XSL9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_027660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027660"/>
    <dbReference type="HOGENOM" id="CLU_037139_0_0_1"/>
    <dbReference type="OrthoDB" id="5373426at2759"/>
    <dbReference type="PhylomeDB" id="B0XSL9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="438" mass="48726" checksum="B41263C279825801" modified="2008-04-08" version="1">MSRRRASNSESIASSSTMNEAVAYPFSGMQQNHLPQRRGPIEGPNGRRLIRRVTWRSSTYKLMASLWVLGVFYIVWLIRDLFWLPFAPSETESTAGKDFLAHYAGRQECGISSVSLYNPPEDQQYCQTRDSLLSAMSNGGRHGFDAAYASQGTSGIGWPYRLLINVSSQILLLTLGTVLLTYLGCVYRWYSSSQICDILQKFDGIAFIGDESLADAYAGFNILLRENLATGALKDWEMNDMYSEQCRCDSQFTNPSCWLKRISSSEDMFLPGDKSGPRSTYACSTHVPHVFVKVLGSPASRDSREKVQKLLARSDSQKKLVPVIHSVSLSTSFSLSAAESSMDEWLALPEVNKQYTPLLWVGPTAPGHEKLSTDTNIPANSAVWQYALDTTKAARSRGMEVLGMYNATLQAASWDGKHYGEKVAMMQAMMIINWLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSN8</accession>
    <name>B0XSN8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_027840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027840"/>
    <dbReference type="HOGENOM" id="CLU_000050_0_2_1"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="PhylomeDB" id="B0XSN8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001205">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001861">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002324">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002523">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="MDN1_4th"/>
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    </dbReference>
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        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4708"/>
            <end position="4913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="741"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4075"/>
            <end position="4457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4476"/>
            <end position="4496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4519"/>
            <end position="4556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4570"/>
            <end position="4602"/>
        </location>
    </feature>
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        <location>
            <begin position="4144"/>
            <end position="4184"/>
        </location>
    </feature>
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        <location>
            <begin position="4185"/>
            <end position="4205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4219"/>
            <end position="4232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4233"/>
            <end position="4252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4253"/>
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        </location>
    </feature>
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        <location>
            <begin position="4270"/>
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        </location>
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        <location>
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        </location>
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            <begin position="4365"/>
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        </location>
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            <begin position="4410"/>
            <end position="4421"/>
        </location>
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        </location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="4925" mass="550617" checksum="EF72711210A6C0BD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTK7</accession>
    <name>B0XTK7_ASPFC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
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        <text evidence="2">Belongs to the PhyH family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="320" mass="35400" checksum="8765EBD90DDEAAE5" modified="2008-04-08" version="1">MEGLTPSQLAFFRENGYLVIPGFLSPEDITSLLTETNKLLDDFPLESHPLTKFTTGDDETDENNTHVGDDYFLTSGDKIRFFFEPEAFSSTPDPATGKPTLLKPKQQAINKIGHALHSLSPPFEKVSLSARNAAIAKSLGFVDPRVLQSMVICKQPGIGGAVPPHRDSEFLYTRPPSAVGWWFALQDAGPGNATLGMWKGSHRQGIKRRFVRKVGENGKVLGTEFVENDGPKMPRGAEGDGQDPDQGPDVKDENFEILDIKAGSLVLIHGNVLHMSEKNTSPRSRFAYTFHVIEGADGWDYDERNWLQPPEGGEFSKLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV09</accession>
    <name>B0XV09_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_021250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021250"/>
    <dbReference type="HOGENOM" id="CLU_3142742_0_0_1"/>
    <dbReference type="OrthoDB" id="10300921at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="49" mass="5341" checksum="3031DABCC4FCB45C" modified="2008-04-08" version="1">MSKFCFDEFTVADDTNIIITYHQEPSTTFPCASALTACTGSTNLHVHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV67</accession>
    <name>B0XV67_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_021850</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021850"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="PhylomeDB" id="B0XV67"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="275"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="110"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP54133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="716" mass="77324" checksum="8DAEB57D9B3F0C1F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV77</accession>
    <name>B0XV77_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin conjugating enzyme (UbcF), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_032150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032150"/>
    <dbReference type="HOGENOM" id="CLU_041481_0_3_1"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="PhylomeDB" id="B0XV77"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000093">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcF), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="310" mass="33469" checksum="B27128FDF50B2185" modified="2008-04-08" version="1">MTSPSHRRLLKEAAELASHPSPHFTAHPVSDSNLYDWHFTLAGPPPPSPYAGGIYHGRIVLPPSYPLRPPSFRFLTPSGRFEVNREICLSISGHHEETWQPAWGIRTALLALRSFMDADAKGQVGGLDVDVAVRRRYAVESRGWVCEVCEGGRSNEEVLRAWREVCRAKGVEVEEDEVQGAGAGAGGTAERTPSGEAEPTPERDPEDTTDANANANAETETGTESSQKESEPRPSKHATPQQQVQVPVPSVPSAPAPTPAPTHTTPVPTTTATTSQPTTTDAPWLDRAILGVLVALAFMIVRRLAKSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVD7</accession>
    <name>B0XVD7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin 11C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_032760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVD7"/>
    <dbReference type="HOGENOM" id="CLU_052213_1_0_1"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="PhylomeDB" id="B0XVD7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35230" checksum="4A4D4F4C06110372" modified="2008-04-08" version="1">MTDSEKTLVSSEPPVAPEIEAPTVGKPVSPAGPPPPSSSASNDTQRKLLKALKATDYNIERLDRLLSTAYGQERVFAATGYLTHALHHLITSAPWIAVQTRLGLLARLKNRTKSTRNTTAPSSSPQSRLLALSSLMSETRYTIRLLGLVPLWTWGSATLKSPPSDPIIRNLTLAQVAVNMVYQFLENVGYLASKGVISKKWIDRWGGINKWYLWSIRAWFGHIIFQFFVLWRQVVLRRRKIASNPAEAQTKEGQEELRAEIRAWKKALVNNVCWAPLCLHWCFENGVGIPDSLSGVISFMAGAWGFYDLWAATAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVU2</accession>
    <name>B0XVU2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rho GTPase ModA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_022770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022770"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="B0XVU2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="192" mass="21426" checksum="0ABD966CF1836C10" modified="2008-04-08" version="1">MVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQTDLRDDPAVREKLARQKMQPIRKEDGDRMAKELGAVKYVECSALTQYKLKDVFDEAIVAALEPAPKKKSRCVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVU6</accession>
    <name>B0XVU6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 17">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 17">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 17">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AFUB_022810</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 17"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022810"/>
    <dbReference type="HOGENOM" id="CLU_021710_0_2_1"/>
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    <dbReference type="PhylomeDB" id="B0XVU6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:mRNA guanylyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="20">
        <location>
            <begin position="43"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="21">
        <location>
            <begin position="247"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="18">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP54229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="415" mass="48321" checksum="CCB9F4A5A2CAF708" modified="2008-04-08" version="1">MGNPSVPDLDAVGIKAEPELADQFRREVAALLGRNNLNFPGAQPVSFAKRHLLELQREDYYVCEKTDGIRCLMYFARGEEDSPVPEIHYLIDRKNDYRYVPGLHFPQPDDETFQSFHVDTLIDGELVNDTYEDGTQQLKFLVFDCLVLDGQKLMHRTLDKRLAYFKEKVLKPYNALYKKFPEEKKHRAFAVEDKSTQFSYGIEMMFREIIPKVKKIHGNDGLIFTCRSTPYRIGTDEHILKWKPPSENTIDFRLRLEFPVLEPDTDDEADGITEPYPDYDAIPICHLFVMLNANEYQHWGEMYVTESDWEALKALQVPLDDSIVECFKDEQGRWRFHRLRDDKADANHISTVEKVLESIEDRVTEEDLIRAAPAIKAAWKKRQAQAAAEEEDRRRRARQMPPSANGNGVKRKFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWH6</accession>
    <name>B0XWH6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-related protein RO7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_035950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035950"/>
    <dbReference type="HOGENOM" id="CLU_023246_0_0_1"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="PhylomeDB" id="B0XWH6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000215">
        <property type="entry name" value="Actin-related protein RO7, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000081">
        <property type="entry name" value="Actin-related protein RO7, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="561" mass="61715" checksum="FFCBF23D2216BCC7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWI6</accession>
    <name>B0XWI6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deacetylase complex subunit Sds3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_036050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036050"/>
    <dbReference type="HOGENOM" id="CLU_031130_0_0_1"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="PhylomeDB" id="B0XWI6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="506" mass="56047" checksum="D0B4732F1978E340" modified="2008-04-08" version="1">MAYSPAPASPATGTAGQTLSSSLHPRGRSPSPATNAPLSKRDKRRGALQERLHDLTATFSHNRDAQFRQQLHTLQCDMTLINNADPYSPGPLPDSAEEIAALVEKTIGGGAFAKEMANLSGMWYSRFVQEVNQAKEERDAELAALVHRHNNNLERFQREYAFRVHFAGEEYNNLSSTLRERLVQTISGKKARLMREKEQLDIADTNALLLHPNQFSITNPASPGGVHGNRKTRHTRHRVDLDELGNGIVSEFNKRKRKAPEEDTGSPVRDPNPAERAKSQLAEKQHAPTYSIHTLFTEKELSAHANQAHVATVHFFSTSKRADQPSGTTTNGNNTDVEESGTGDGTGQEDNGTPAADMVRTASQNYHATRSTRTHGNHALNALAELSDKPAVRPNLPYNVLANYHARPNSNAPPLPSLMNEEVEDDCARLDRLHNKSAGWVDRNLIELLVERVPAEVDGTPQNPHRFSLLHPDFPTDMGVHLYPLKTNGRDVELQSYERTKKARAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-11-27" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWK8</accession>
    <name>HASD_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nonribosomal peptide synthetase hasD</fullName>
            <ecNumber evidence="9">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hexadehydro-astechrome biosynthesis cluster protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hasD</name>
        <name type="ORF">AFUB_036270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="2064" last="2067">
            <title>A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Yin W.B."/>
                <person name="Baccile J.A."/>
                <person name="Bok J.W."/>
                <person name="Chen Y."/>
                <person name="Keller N.P."/>
                <person name="Schroeder F.C."/>
            </authorList>
            <dbReference type="PubMed" id="23360537"/>
            <dbReference type="DOI" id="10.1021/ja311145n"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2022" name="J. Fungi" volume="8" first="0" last="0">
            <title>Stress responses elicited by glucose withdrawal in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Emri T."/>
                <person name="Antal K."/>
                <person name="Gila B."/>
                <person name="Jonas A.P."/>
                <person name="Pocsi I."/>
            </authorList>
            <dbReference type="PubMed" id="36422047"/>
            <dbReference type="DOI" id="10.3390/jof8111226"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2025" name="MBio" volume="16" first="e0387424" last="e0387424">
            <title>Gene regulatory network resource aids in predicting trans-acting regulators of biosynthetic gene clusters in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Seo H."/>
                <person name="Bok J.W."/>
                <person name="Keller N.P."/>
            </authorList>
            <dbReference type="PubMed" id="39964163"/>
            <dbReference type="DOI" id="10.1128/mbio.03874-24"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hexadehydro-astechrome (HAS), a tryptophan-derived iron(III)-complex that acts as a virulence factor in infected mice (PubMed:23360537). Within the pathway, the NRPS condenses tryptophan and alanine to produce the Trp-Ala dipeptide (PubMed:23360537). The 7-dimethylallyltryptophan synthase hasE then catalyzes the prenylation of the hasD-tethered tryptophan or the resulting tethered Trp-Ala dipeptide at the C-7 position of the indole moiety. HAS biosynthesis continues via tethered intermediates with the succesive actions of the cytochrome P450 monooxygenase hasH, the O-methyltransferase hasC, and the FAD-linked oxidoreductase hasG. The resulting O-methylated diketopiperazine is then released from hasD. Finally, three O-methylated diketopiperazine molecules assemble in a trimeric complex with Fe(III) to produce hexadehydro-astechrome (PubMed:23360537).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="5 6">The expression of the hexadehydro-astechrome cluster is induced by glucose (PubMed:36422047). Expression is negatively regulated by the GATA-type transcription factor nsdD (PubMed:39964163).</text>
    </comment>
    <comment type="domain">
        <text evidence="9">NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. HasD has the following architecture: A-T-C-A-T-C-T.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Does not accumulate prenylated tryptophan derivatives.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="9"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0XWK8"/>
    <dbReference type="EnsemblFungi" id="EDP52461">
        <property type="protein sequence ID" value="EDP52461"/>
        <property type="gene ID" value="AFUB_036270"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036270"/>
    <dbReference type="HOGENOM" id="CLU_000022_0_5_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B0XWK8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17653">
        <property type="entry name" value="A_NRPS_GliP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19537">
        <property type="entry name" value="C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000031">
        <property type="entry name" value="Nonribosomal peptide synthase GliP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000062">
        <property type="entry name" value="Nonribosomal peptide synthetase gliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000461228" description="Nonribosomal peptide synthetase hasD">
        <location>
            <begin position="1"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 1" evidence="2">
        <location>
            <begin position="588"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 2" evidence="2">
        <location>
            <begin position="1634"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 3" evidence="2">
        <location>
            <begin position="2201"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 1" evidence="1">
        <location>
            <begin position="696"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylation 2" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Condensation 2" evidence="1">
        <location>
            <begin position="1735"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2174"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2186"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="1673"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="2235"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q4WYG2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23360537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="36422047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="39964163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="23360537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="23360537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2273" mass="249904" checksum="946DA115F90AE8EF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWX1</accession>
    <name>B0XWX1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_036710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036710"/>
    <dbReference type="HOGENOM" id="CLU_026929_4_0_1"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="PhylomeDB" id="B0XWX1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="493" mass="53330" checksum="5F4F0591A3BB8CE0" modified="2008-04-08" version="1">MLLTLKPSAPNRIKGPHEYAIVRQSIPTPRSSPPTVPDASTPKPSRRVLPPPSSISLQLDVGRSNMAPMSQLPPAPTGWSSSEDLRQWLQAKAEEDRRLQEEEKTRQESLRLEQRKIEQSMLRDSLQSGVPPQMIPLIFAGITGGSLPQSAIELIQQYASQNPGTHSNAPPPPSRPSAPLHQQQQSTLDILPPPPTLSQRHPSLAIPADIRRDSRGHPSTTYATLPPHQQPIPGPALSQPLTTHGRSPTIQSLGRPPLPSGAGKATASSLSRINGDTPSQHVPLTLSDSKYATGSSLPPSQPVGVKQEQTPRHSPPSLYFHHWVPPGQPPPAKNQHDSTVISIAQPQRRYEYQSSPGRKRKSQIPHQPAPLPSSRPSDAPSSPLPSSRLGSPIASNQPPDSQTHNRQRTDTSSSHDLRMQNHREANQGNDSLHQKAGVSITNQQSVDLSPTKDSNRGDVSSENAGVRYRASHTSDNVNNSSKAEDAAEASSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX36</accession>
    <name>B0XX36_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cholestenol delta-isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_047590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX36"/>
    <dbReference type="HOGENOM" id="CLU_072128_0_0_1"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="PhylomeDB" id="B0XX36"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="55"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP53577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="225" mass="26507" checksum="68472A6C12A7612A" modified="2008-04-08" version="1">MIPHYYYPPTIRLPHYSANETSVLSLITQFGFLWAAVLGIAFIVIRRTRPTVSRSDQLSFIWMCLTGFIHLFFEAYFVTHHESLAGAQQLFGQLWKEYSLSDSRYLTSDAFLVSMEAVTAFCWGPLAFFIAYCIAVQHPLRHALQLIMSTGQVYGDVLYYATSLFDLYFHGVIFCRPERYYFWFYYFFMNFIWIAIPSYHVYQSVVEITRAFRRLGELDQRQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXW8</accession>
    <name>B0XXW8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_038830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038830"/>
    <dbReference type="HOGENOM" id="CLU_026793_0_0_1"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="PhylomeDB" id="B0XXW8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="496" mass="54435" checksum="0CBC6FE21AFB3CC9" modified="2008-04-08" version="1">MASAPGYPATTSRARSSDATSVRDETTANTDRGSFTGDSPAESMEGNETVFLNKPVASSEDVSTAASDTATASKSPVPSSTATESVNEEPRKCWICYTDETEDSPLNSEWRSPCPCALTAHEACLLDWLADLENPRSRKRNGHGAKMVCPQCKSEIVVSRPRSYIVDVVRMFERLAGRLVLPGMVFTLAGTVWAGCCAHGVYSMYFVFGTEEARQILEETADGTWNSGLNLGLPLIPLVLIFSRTRYAEGLLPAIPVLFFATHNSAQELDLDLWPPSAAMTFAALPYVKSFYSAVYHRLFGKLERKWIAEVQPRQADINEFDDNAPPEHPEGRNDAENGQILMEIDLEFQVGMGNDVRQGILGLHAGENAQNNGQNQGGGQNENNLGLGRRDDLIHETSNLADIILGALAFPAISASMGGLLKYILPKSWTTAPSALERGRPGLLQTRWGRSVIGGCVFVLLKDALVLYCRWKLAQTHRKRKVLNYDRKKKKVVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY22</accession>
    <name>B0XY22_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_039370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY22"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_1_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="PhylomeDB" id="B0XY22"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="62"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="300" mass="32862" checksum="B4BA8C3CBBDC0639" modified="2008-04-08" version="1">MSTTTITESAKQTLVVTPDKITPAAADEKFQAIARGNREGTLKLQGIPTFSDPYEQRKWMKEHMAAAFRFFGKQGYGEGVSGHISMRDPVLKDHFWMNPFAKHFSTIKASDLVLVDSEGYVTEGGAQLPINEAGFMIHSEIHKARPDVVAAAHTHSIHGKTWSAFGRPVEMLTQGLCYRYTMKGCGWRTLTLPVDACNFYGKLSVYDDHGGIALAREEGEQIAKALGEKNIACILQNHGLLTVGHTVDEAAFLFFSLDNACRSQLMADAAAANGVPKKIINHEVAQYTADAVQNPVCFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY55</accession>
    <name>B0XY55_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase, putative</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_039700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY55"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039700"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="PhylomeDB" id="B0XY55"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="183"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="317" mass="34111" checksum="0B15BEEBF0245AD0" modified="2008-04-08" version="1">MDIKSLGSSYCKENLLKKLEDGARLHVYDVDDRALRNFEAEAPTKGRVCSNAREVAESSVRITTCKSREADQLTNAAPRRFLFTMVPEGRHVRSVYLDSHAGVLTTSVDDKILVDCSTIDTATSMDVGAAVCQNSKTAAFYDAPVSGGSLGAVAGTLTFMVGCVEDDPNLELLIFPCGGFLLGLTAKLCNNYCSGLIAIATAEAMNIGIKSGMKPSLLARVFATSTAQSTINDKWNPVPGCLSECPGEQGVQLMKKDLALAVEAADRVGAQLRLGVPALQVYQEAREDERCHDLDSRVVFRYIGGDEDWETKLSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY61</accession>
    <name>B0XY61_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Spindle-pole body protein (Pcp1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_039760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039760"/>
    <dbReference type="HOGENOM" id="CLU_002168_1_0_1"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="PhylomeDB" id="B0XY61"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="256"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1251"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="721"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="798"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="871"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="987"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1271" mass="147088" checksum="77A0294AA91E45B1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYG1</accession>
    <name>B0XYG1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_040800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040800"/>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="PhylomeDB" id="B0XYG1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000143">
        <property type="entry name" value="DNA replication factor C subunit Rfc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="394" mass="43366" checksum="6E23DC44003B177C" modified="2008-04-08" version="1">MAANFFNNKARAAAAAAAAASTSSKQKPTDGKEEQTRLQPWVEKYRPKTLDDVAAQDHTTKVLQRTLQASNLPHMLFYGPPGTGKTSTILALAKSLFGPALYRSRILELNASDERGIGIVREKVKGFARTQLSQPTGLDSSYFEQYPCPPFKIIILDEADSMTQDAQSALRRTMEQYSRITRFCLVCNYVTRIIEPLASRCSKFRFKPLDNSAAAERLAHIARLENLKLDEGVIDKLISCSEGDLRRAITYMQSAARLVGAGRPTSQKDGDEDSEMTDASSEPVTMQMIEEIAGVVPESVIDRLIQAMQPKKLGSSYEAISTVVTDIVADGWSAGQLVLQLYRRIVYNDAIPDIQKNKIVTAFSEMDKRLVDGADEHLSILDLALRISGILGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYI5</accession>
    <name>B0XYI5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_041040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041040"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="PhylomeDB" id="B0XYI5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062139" evidence="5">
        <location>
            <begin position="16"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="610"/>
            <end position="611"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="629" mass="67679" checksum="7DFEA50D95A1815C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ28</accession>
    <name>B0XZ28_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome regulatory particle subunit (RpnC), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_042940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042940"/>
    <dbReference type="HOGENOM" id="CLU_019858_1_1_1"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ28"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="384"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="638" mass="70759" checksum="37670A95ABB73488" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZG4</accession>
    <name>B0XZG4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044320"/>
    <dbReference type="HOGENOM" id="CLU_021768_0_0_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="PhylomeDB" id="B0XZG4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="339" mass="39675" checksum="FB9B038D878A133B" modified="2008-04-08" version="1">MTCEREPVRLTQWKIPNSLSFVVEDSSFFQKWDRLPSPNEVQARARTQHQHLAGGYPNQNKVHSMTTPYVRPPPVIFEEMGLFVKWGSSVQISEAQCLFAVHQFIKGDVPVPEVYGWRTEGNEAYIYMEYVNGQSLEQAWPSMGYEDKAGISRELRTIFQRLRQVEQDPEDPFVGANIPGTLWIRDCRQLTFLFVGNITKGPLYDRAFHVNYMHEAGPFATVRDFHDWFTFLHRRPMPDPYSVPVEPFRHDLPDDCAIKFTHGDLHRSNIIVTSTRPYRILAVVDWEQSGWLPEYWESRKAQYTADRADEWSLTYLPMIMEQFPSTWDPWDYYTSAMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZN8</accession>
    <name>B0XZN8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_044700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044700"/>
    <dbReference type="HOGENOM" id="CLU_073125_1_0_1"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="PhylomeDB" id="B0XZN8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF4">
        <property type="entry name" value="NITROREDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="196" mass="21670" checksum="B39476484227404E" modified="2008-04-08" version="1">MSSVTAEQWLEAAAYRRTVYGLAGTSKVSDKRVEEIVSKPVRVSLAFGAKHKELWSIIIKVAEPVLTSMNPDLWARFGPILEAHKAAYGSVLFWECGETIKESSEKHKHVAHKLGEWSDVSQGMHQILVWTALGLEGVGANLQHTNSIPPIEAAIKKFAGVPEHYTLKAHLNYGDKQADHPEKPAKLPMGEILMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZP6</accession>
    <name>B0XZP6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_044780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044780"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="PhylomeDB" id="B0XZP6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF42">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="224" mass="25005" checksum="ABF5E5CA7319E6AF" modified="2008-04-08" version="1">MGVPDSTNSDLFHNWAKLPISREQFARELREEVHRQFQTCTPLPGAEKLLSNLNSARSTCSGERIELALASSTKTHTFDLKMSRPETKKLLNIIPSERRVLGDDPRVGQGRGKPAPDIYLVLWQALNSTADSGKPILPSECLVFEDSVAGVEAGRRAGMRVIWVPHPDLAVEYEKRQREVLAGRTGMIEIGDEWQLGEIDDGWAESIPSLDFFDYEKYGIVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZP9</accession>
    <name>B0XZP9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MFS siderophore transporter MirB-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_044810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044810"/>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="PhylomeDB" id="B0XZP9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF55">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="82"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="598" mass="65957" checksum="2F389140617E74A4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0K0</accession>
    <name>B0Y0K0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_057590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0003995">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
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        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
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        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
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        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="647" mass="70934" checksum="34B0AAFA8641E670" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1Y8</accession>
    <name>B0Y1Y8_ASPFC</name>
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        <recommendedName>
            <fullName evidence="6">Cell-cycle control medial ring component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_050300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1Y8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050300"/>
    <dbReference type="HOGENOM" id="CLU_075131_0_0_1"/>
    <dbReference type="OrthoDB" id="5366541at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1Y8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.70:FF:000001">
        <property type="entry name" value="Uncharacterized protein B2O8.280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.70">
        <property type="entry name" value="Get5 dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049256">
        <property type="entry name" value="Get5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024737">
        <property type="entry name" value="Get5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF20">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17183">
        <property type="entry name" value="Get5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12754">
        <property type="entry name" value="Get5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Get5 N-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Get5 C-terminal" evidence="3">
        <location>
            <begin position="221"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29596" checksum="66F43F8FC2216EFE" modified="2008-04-08" version="1">MSTVDQSTVTTALSSSSSNRHQGNDTYSIPKHSGTTSTITITMNEVSFVKSYLSTLDSRPIKLRSDHVFDPEQVGLRVPYTLPRLHAPHPEMPKKTKQPLAPGSSKSITVHLKSARNPALEFSLPNTALTTTSVQDLKDAVRERVTDAQGNKISLDKIKILYKRKPVTGKTIAEVLADEPGMLSGGKEVEFGVMIIGGAQVAVSAGAGERAGAEQKESYEPPKPAVGPSGESVVATEAFWDDLQGFLEQRLKDYDEANKLRVLFKEAWRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y262</accession>
    <name>B0Y262_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_061400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y262"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061400"/>
    <dbReference type="HOGENOM" id="CLU_946563_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="294" mass="31552" checksum="CE2BEC6CBEF447CC" modified="2008-04-08" version="1">MRLNPRDKGQKAPKRVRVHHLEQPGQRNEVHDDCFQPRDPGSTELFYTTADVQALTTDNKLRAVTCKAVLVDGGSEGNLVARYVVSALKASIVPVDIRCRVATGHDFRLSAIVWLQLTIEGVSSIIAATVVDGDPGYSIIKVAAGAVCNNLTGSFNDLVLCSLQLSAVLLAGEDLLLILHTGHDEANAGCLGAALANSANLGKCLVFDTLQKIRLKKDSLEGTSIGIASPNDPSGGHEDAWTLNPHAIILCLSSGVKILKGIHIALVIFVKDQKKSDWEIYLPRPSKTLVDEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y277</accession>
    <name>B0Y277_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transulfuration enzyme family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_061550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y277"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061550"/>
    <dbReference type="HOGENOM" id="CLU_018986_3_0_1"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="PhylomeDB" id="B0Y277"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF84">
        <property type="entry name" value="ENZYME FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="395" mass="43451" checksum="41AF9DB2F983C361" modified="2008-04-08" version="1">MMPLSQDSHPSTKALHADGRLNLVTDVAPPIHLSTTFRYPNDPDQLIPSEDPIAEFDGKNYVYSREFAPNATRFEAILSTLLGSHAVSYATGLAALHAALVLLNPRRISVGEGYHGSHEVIGVLTRLTGLKKLPLDCPAEDLQEGDVILLETPVNPLGTAFSIEAYAQKAHSRGAYLIVDSTFAPPGLQDPFLWGADIVLHSGSKYFGGHSDMLCGVLGVKRAEWHRQLLEDRAALGHVMGNLESWLGVRSLRTLEVRVQRASQNSAKLISWLNDALTAASPTPGSEEEIVQKVLVKIYHASLQDEEWLKRQMPNGFGPVFAIVMKDERLAKTLPSKLSLFQHATSLGGVESLIEWRALSDSRVDRKLLRISVGLEDWQDLKMDLLSAFKSLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2C6</accession>
    <name>B0Y2C6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Farnesyl-pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_050980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050980"/>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2C6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="347" mass="39694" checksum="81E0E8610AC6184B" modified="2008-04-08" version="1">MATTTSRAAFEAVFPTLAEDLLAHAKKYNLPENAVKWFEQVLNVNVPGGKLNRGLSVPDTGIALLQKPLTDEQFKHLSILGWLTELLQAFFLVSDDMMDSSITRRGQPCWYRHPGVGLIAINDAFMLESGIYVILKKHFRSHPAYVDFLELFHETTWQTELGQLCDLITAPEDKVDLDNFSMEKYMFIVTYKTAYYSFYLPVALALLYLELATPENLQQTHDILIPLGQYFQVQDDYLDAYGDPAVIGKIGTDIQDNKCSWLINQALQRCNTEQRKLLDTAYGRKDSELEAKVKALYKELDLEKVYKEYEEKTVGEIRSKIAAIDESQGLKKEVFEAFLGKIYKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2R6</accession>
    <name>B0Y2R6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_051700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2R6"/>
    <dbReference type="HOGENOM" id="CLU_1045765_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="266" mass="29297" checksum="870F731E6C72475B" modified="2008-04-08" version="1">MKATRSQVSPKLGAKRFRHRFSPEDELEQCFTENAARERRFSTPSVKHEVLQSVEIQKPRRLDRSGSPSLHGHPTKERRGSESRESPDELQGAATVQPAQDFSREFHKKDVRGGFKAGKQVAQRKTSPADIRPTVFVPSSHQGKSKRKITKSGTRPSADRCFQATSIRFGTITGPSSGDKAVEVHVDPINETIKMAGPDPANSFQIPFNKVYKIFRGTSPSCKVRLALREGTGDQSVDIDLTSPEAKEDLYALLAGSGAKVVEKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3F4</accession>
    <name>B0Y3F4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_054010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054010"/>
    <dbReference type="HOGENOM" id="CLU_1570258_0_0_1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="170" mass="18828" checksum="7CCD65C9EFAE89DC" modified="2008-04-08" version="1">MIFILSVIQVSLSTSGGTTLKLAQNLQLLILLDNMPQGVHSIPKLEDLIQERLPALTLYYFLAIEKSHLQSQWYLPRPAVEDNWSACLQTFEGHSKPVNSVLFSHDSKLIASASFDQTVKIWDATSGHCLQMVNAGGVIRVKSFAHINSYVELDYGIIGLSFLGFTCNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3G7</accession>
    <name>B0Y3G7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SNF2 family helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_054140</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3G7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054140"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3G7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="405"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="733"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="805"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP51408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="975" mass="108768" checksum="460672DFABFF6939" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3J1</accession>
    <name>B0Y3J1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_054380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054380"/>
    <dbReference type="HOGENOM" id="CLU_849861_0_0_1"/>
    <dbReference type="OrthoDB" id="5511210at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="174"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="327" mass="37452" checksum="6C61B31661D58190" modified="2008-04-08" version="1">MQHSCHFSQHPLAWDISMLEEHPFFAHPPPPPPPYHDSFESSSGEPSKCKTKGTKERAKKGMNDEHPEEPEIRSGHSCGRGRREFHHRHPGLGHHLHPHVHEHDEEHGFSRWSEQEGLGFGHHHHHRYNPPWGMFRGLGRGRGRGRGRGRGFGPHFYHFHHAMHPGFHFFHHSHDPTRFTPPVDVFVTPTHTIIHVSLPGAQRSDLSVAYDASRAVLRMAGVVLRPGVDEEMRRALLIGERGRHLGVFEREMPISHSVAVEGIRARLVDGVLRVALPRVEGDVPQPDEEMDEVDRESASREFNSDGKEEEREVEDEVEREYVKVDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3J4</accession>
    <name>B0Y3J4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-keto-alpha-glucoside-1,2-lyase/3-keto-2-hydroxy-glucal hydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_054410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3J4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054410"/>
    <dbReference type="HOGENOM" id="CLU_446322_0_0_1"/>
    <dbReference type="OrthoDB" id="4526039at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="AL/BT2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="3keto-disac_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-keto-alpha-glucoside-1,2-lyase/3-keto-2-hydroxy-glucal hydratase" evidence="1">
        <location>
            <begin position="292"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="626" mass="65528" checksum="E6B5F9F5F88DD3FB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3Q8</accession>
    <name>B0Y3Q8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 pisatin demethylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_055070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3Q8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055070"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3Q8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF188">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="477" mass="54715" checksum="ABABCC8FD1F4F5E3" modified="2008-04-08" version="1">MFLIIVIPIVILLYPFLSTLYTTLRTRSLRRIPGPFLTRLTKLWYFYRVRAGHFETDNIALHRRYGPVVRIAPDHYSISGSAAIKTVYGTGSKFTKSAWYEGWKHPDPNQWTLFPDRNIKRHAETRKRFSSLYSMTSLVHYEAFVDRCADLFCMRLREFAARGEEFNLGHWFQCYAFDVIGDITYGQRFGFLDRGEDIEGTIAALQRLMTYSTLVGIYPEWHPRLFGPLSRFSWSGAAGRAYIVRFVQEKIRGLSVKADPGQVERGPLATQNFVEKMMLARDKDPEKVTDYHVFMMGLSNVIAGSDTTAISLSAIMYHLLRYPAVMEKLRREIDAFAADGKCSDSVTFRESQEMPYFQAVIKEALRMHSATGLPLWRVVPDGGVEINGYFFPAGTVVGINTWVAHYDEEVFPDATTFRPERWIEAESNPEKLRAMNEMYMPVGLTHFSRIQHTDDGSSALGLGRVLESTSPFWKCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y417</accession>
    <name>B0Y417_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear protein Qri2/Nse4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_056190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y417"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056190"/>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="PhylomeDB" id="B0Y417"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31602" checksum="D25DE3F4AD45EEB6" modified="2008-04-08" version="1">MPRLFPSNPEEVMVIRNVTSDVITLSLPFARFGRLKFGARGTLVKLPSGSLAVFSPVSLTPQVREMISQMGQVKYIAALDLEHHIHLTPWKEAYPDAEIIAPEGLWEKRQSNPEYKNTPFSHIFRKEDQHKGSRKISEEFDAEFESEYVYGHPSRELVFLHKRSRTLIEADLMFNLPAREQYSWTKEGATSGIFAKIINTVMSAEPPATWQKRFAWYILSSADRKAFTESMRRIDQWDFNRLIPCHGDTIESGAKGSFRTVMEWFLENNRRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4G0</accession>
    <name>B0Y4G0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallothionein-I gene transcription activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_068960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4G0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068960"/>
    <dbReference type="HOGENOM" id="CLU_179456_0_0_1"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4G0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="76" mass="8249" checksum="B02C6CEC58027A36" modified="2008-04-08" version="1">MSREAYQVPSLGAQNTFGTEGMAAGSMDGPVVAYLCGECNARVSLKRGDQIRCKDCGHRVLYKERTKSENLSVCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4Q6</accession>
    <name>B0Y4Q6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCCH zinc finger and SMR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_069920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4Q6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069920"/>
    <dbReference type="HOGENOM" id="CLU_015244_0_0_1"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4Q6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.110:FF:000002">
        <property type="entry name" value="CCCH zinc finger and SMR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="604"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="733" mass="79726" checksum="6454A4D95703F0B7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4X3</accession>
    <name>B0Y4X3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_070620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070620"/>
    <dbReference type="HOGENOM" id="CLU_024640_0_1_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4X3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54095" checksum="8DA90A3C0A4B4DC8" modified="2008-04-08" version="1">MQRLHSFSQLRHASPLKLFALAAAFILVSASLVFYSRPASPSDVDLLPSQPSTGNEIENKGTCYVDLDFLRSQGYNETAKYARLEIAVRRTANFTGFSDTLPTRFPAYQKIRLDTADHEAPLSPETCSPAVTIQAPLPVAPPNASHILFGVATTLRRLDDSLPAFAHWAAGTNARIYASVDSDTGSPIRRVEQRAKELDVRLTIIQSDEERLDQYFSLLRVLLKHRDASTQWAVLIDDDTFFPSMRNLVDRLATYDATKPQYVGAVTEDLAQVFSWSYMAFGGAGIFLSIPLLEQLDKVYDDCNSFKTTGDRRVARCIYSHTHTKLTWDRDLYQLDLRGDASGFYESGRPLPLSVHHWKSWFQADMVGLGQVAAVCGDDCQLHRWRLKDNWFLVNGFSMIKYTSARNVDLMEKTWEDSKYRGGDGFAFSLGPFRPKDEGKVSFRLRNATQQAGSVRQVYIHDSGPDEPPEVLEVVWKPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y595</accession>
    <name>B0Y595_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0075 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_071840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y595"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071840"/>
    <dbReference type="HOGENOM" id="CLU_038782_1_0_1"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="PhylomeDB" id="B0Y595"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24051">
        <property type="entry name" value="ASKHA_NBD_LGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="443" mass="48798" checksum="A4933F97B406F030" modified="2008-04-08" version="1">MTVTGATNGASSHPALDLTVLGLNSGTSMDGIDCALCHFRQETPESPMHFELLKYGEIPLEQTIKKRVMNMILHNKTSPSELSEVNVILGETFAAAVKEFCQEHHVDIETIDVIGSHGQTIWLLSMPEPGEVRSALTMAEGTFLASRTGITTVTDFRVSDQAAGRQGAPLIAFFDALLLHHPTKLRACQNIGGIANVCFIPPDSHGGIDACYDFDTGPGNVFIDAVVRHYTNGAQEYDKDGEMGARGTVDQELVDEFLQNHLYFRLDPPKTTGREVFRDTLAFELIRKAESKGLSPDDVVATITRITAQAIVDHYRRYAPKDLPIDEIFMCGGGAHNPNIVQYIQKHYPNTRILMLDAAGIPGGAKEAITFAWQGMEAIVGRSIPVPTRVETRQEYVLGKVSPGKNYRKVMRHGMLFGQGRDHLSPVSEMVNYVNGKVFDNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5C9</accession>
    <name>B0Y5C9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_062960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP49964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062960"/>
    <dbReference type="HOGENOM" id="CLU_010194_4_3_1"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5C9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="308" mass="33710" checksum="34B414B23B1C367F" modified="2008-04-08" version="1">MQEYTEKPASGAESQFQPGHRIPIQHQKKPGLQAELEDPKPASTRIPTDDYGYQTYKAAGKLAGKRAIITGGDSGIGRAVAILFAMEGASSLIVYLPEEEIDAQETKRRVQETGKECHCLAVDIRKRENCQKVVDVALRCLGGIDILVNNAAFQNMVQDISELDEDQWHRTFDTNIHPYYYLSKYSLPHMRSGATIINCSSVNHYIGRGDLLDYTSTKGAIIAFTRGLSNQQIGKGIRVNCVCPGPIWTPLIPSTMDTSAMEQFSSVPMGRPGQPSEVATCFVFLASHDSSYISGQSLHPNGGVMVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5R0</accession>
    <name>B0Y5R0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_064270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5R0"/>
    <dbReference type="HOGENOM" id="CLU_040208_1_0_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5R0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="407" mass="45097" checksum="C21D05467EA76A2C" modified="2008-04-08" version="1">MGLSFHLYSFYPLTQAPQGSASQSGSGFPSRRSYPSLNHVSLAPLTNRFPIDDDTEPEDYFSPRDERSADTSTRTSYLSSFSVPGTPGVLSYSRSGSRVRLHSRSKSSSRIHRSDSSLQSQDDARPLHHHQHAHGPKKKHTSSSRHQPSESAGRRDAEWMLRAGIALASSTREEKGQSWLVKRESSTSLVSETNVDSPVLARRSRSGRSTPAAHSRWGSRAASRRNSRHDLAMTSLDALPTRSGSNARDSTRPHEETRHFIPDFVDERIRAEMAFIQQFEDGYASASDEESDSEDEIDEQELQRLTRERGFGLGGWIDRMVEWTLFGVEDLPLSANVQSAELAKHPDSSPDNDSVRDDHSSAAELTDDNASVSADESIASTVVEKPGENGGWADVGWFLRVMKRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y610</accession>
    <name>B0Y610_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_065270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y610"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065270"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B0Y610"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="531" mass="57658" checksum="B6E885CEF1F69058" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6N0</accession>
    <name>B0Y6N0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_067530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6N0"/>
    <dbReference type="HOGENOM" id="CLU_073661_0_3_1"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6N0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="205" mass="22168" checksum="DE0F6669C6B61AA8" modified="2008-04-08" version="1">MAELDRVPPSTTAYVIATAILAGITGYFIGQGASLGLFSWAKEKEGWPNSYNVKIPQHSSDEEGENYEDDSEEEGDGGELANFDASNEEVKLVLVVRTDLGMTKGKIAAQCSHATLACYKYLIAHNPQSPILRRWEQQGQAKIALQTKSEEELQLLHAQAMSLGLCARVIQDAGRTQIASGSRTVLGVLGPKSVVDQVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6U8</accession>
    <name>B0Y6U8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_068200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6U8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068200"/>
    <dbReference type="HOGENOM" id="CLU_423329_0_0_1"/>
    <dbReference type="OrthoDB" id="4227365at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72040" checksum="62B3CED3D57C0B39" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y719</accession>
    <name>B0Y719_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_072260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y719"/>
    <dbReference type="HOGENOM" id="CLU_089358_2_0_1"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="PhylomeDB" id="B0Y719"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="177" mass="18603" checksum="B06BE892CAF23AFD" modified="2008-04-08" version="1">MAIIQPLVEGAKKSLLAAGVLEEDITLETVPGSYELPFAAQRIYTASQLQAAKGSSSAGGISATDLLSSSTADLSKTSPTSTAAKPFDAIIAIGVLIKGETMHFEYIADAVSHGLMRVQLDTGVPVIFGVLTVLTEEQGLERAGLGKKGMHNHGEDWGKAAVELGLKRRDWVEGKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y770</accession>
    <name>B0Y770_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein YMR-31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_072770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y770"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072770"/>
    <dbReference type="HOGENOM" id="CLU_129439_1_0_1"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="PhylomeDB" id="B0Y770"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12980" checksum="0DEC30AD12944C4F" modified="2008-04-08" version="1">MRATIALRNAARTPLIRFVGRRSVPQSIDHTPRPHPASPSGILPDSFAAYRSKAQQHGPLGRASFTQGSIGRLPGAALGPVQPKQGEFFDRAELPARFHRLPWTEAEIEAIETGGASLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7D3</accession>
    <name>B0Y7D3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_073410</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7D3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073410"/>
    <dbReference type="HOGENOM" id="CLU_015439_0_1_1"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7D3"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="33"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="394"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP49314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="527" mass="58385" checksum="1EDA2BF34C0C32A3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7P7</accession>
    <name>B0Y7P7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_074550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074550"/>
    <dbReference type="HOGENOM" id="CLU_000288_19_1_1"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7P7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21742">
        <property type="entry name" value="MobB_NDR_LATS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001962">
        <property type="entry name" value="Serine/threonine-protein kinase cbk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059233">
        <property type="entry name" value="MobB_NdrA/B/Cbk1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="398"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="816"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="825"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP49428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="973" mass="110105" checksum="6F56C4C56FD01945" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7T8</accession>
    <name>B0Y7T8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1 snRNP splicing complex subunit (Luc7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_074960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7T8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074960"/>
    <dbReference type="HOGENOM" id="CLU_030397_1_0_1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7T8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="279" mass="31211" checksum="80E382C01D4C26B3" modified="2008-04-08" version="1">MAAEQRKLLEQLMGADQLIGTGGGSRNAQLQITDPKVCRSYLVGTCPHDLFTNTKQDLGPCPKVHSEGLKTEYETASAAEKAKWGFEFDYMRDMQKYIDDCDRRIDSAQRRLEKTPDEIRQTNNLLKQISDLTKTINTGLLEVSVLGETGAVAQALNELHKIRTAKHQKETCERELKNLQDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFFGKMHMGYSDMRKTYKKLSEELKGRPPPVRHHDDDEGGWGGRSGGGRGPRYGGGGGGYRKRGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y850</accession>
    <name>B0Y850_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor (PRO1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_076110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y850"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076110"/>
    <dbReference type="HOGENOM" id="CLU_015493_4_0_1"/>
    <dbReference type="OrthoDB" id="5069333at2759"/>
    <dbReference type="PhylomeDB" id="B0Y850"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="573" mass="63201" checksum="4A93834FF899F52D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8L9</accession>
    <name>B0Y8L9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_077820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077820"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8L9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP49750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="288" mass="32798" checksum="FD0EA77CCF388BFD" modified="2008-04-08" version="1">MPDTGDSEEAFFAFYRYDPSMSAAVLFTLLFIGTTGYHAFQMFKTRTWFFIPFVIGGIFEIIGYIGRAMSSKETPDWTLGPYIVQTLFLLLAPALLAASVYMLLGRIILLLQAESHALLGRKWLTKIFVTGDVLSFLLQGAGGGIQSSGNLDNLKNGERIIVVGLFVQIFFFASHFYWKIKKYPIPRSCTPEIPWGKHLHVLYLTSFLIMIRSVFRLAEYLQGNNGYLLHHEIYLYIFDALLMFITMVTFNVVHPCEVGRLLRSTVNYELTHRPETCANKPYASSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8P9</accession>
    <name>B0Y8P9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_078120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8P9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078120"/>
    <dbReference type="HOGENOM" id="CLU_008599_1_1_1"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8P9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="704" mass="78438" checksum="E49A5480E0957FD1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-05-29" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8Y4</accession>
    <name>HAC2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine protein kinase AFUB_078980</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Subtelomeric hrmA-associated cluster protein AFUB_078980</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_078980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2019" name="Nat. Microbiol." volume="4" first="2430" last="2441">
            <title>Fungal biofilm morphology impacts hypoxia fitness and disease progression.</title>
            <authorList>
                <person name="Kowalski C.H."/>
                <person name="Kerkaert J.D."/>
                <person name="Liu K.W."/>
                <person name="Bond M.C."/>
                <person name="Hartmann R."/>
                <person name="Nadell C.D."/>
                <person name="Stajich J.E."/>
                <person name="Cramer R.A."/>
            </authorList>
            <dbReference type="PubMed" id="31548684"/>
            <dbReference type="DOI" id="10.1038/s41564-019-0558-7"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Serine/threonine protein kinase; part of the subtelomeric hrmA-associated cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting in a loss of vertically aligned polarized growing filaments (PubMed:31548684). Consequently, this hypoxia-typic morphotype (called H-MORPH) with altered biofilm architecture leads to increased hypoxia fitness, increased host inflammation, rapid disease progression, and mortality in a murine model of invasive aspergillosis (PubMed:31548684).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is regulated by the hypoxia responsive morphology factor A (hrmA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8Y4"/>
    <dbReference type="SMR" id="B0Y8Y4"/>
    <dbReference type="EnsemblFungi" id="EDP49865">
        <property type="protein sequence ID" value="EDP49865"/>
        <property type="gene ID" value="AFUB_078980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078980"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8Y4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000460410" description="Serine/threonine protein kinase AFUB_078980">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="67"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="31548684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="31548684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="31548684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP49865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="393" mass="45160" checksum="7DE39EA4F29C942D" modified="2008-04-08" version="1">MTPFHRLSRFFRQAPSPPRTPITSNFPILDSAVKIEEERMPAFDRGLFYPVKLGDVFRSRYQVLSKLGFGANSTVWFCRDLHQHRYIALKIYIRSSEVNREVQVLKHLSSVKTNHPGSSLVRKMIEEFEITGPSGSHQCIVYEPLLTSLLHFQATLKPQSLPEDLLKGALQQLLLALDYLHSEAHVIHTDDSIFREWDTSEEAEPSPRKVDSSHTIYKSRPFHRKKGWSGFGMPLLSDFGEARLGDVHDGSIQPDIYRAPEVILGMSWTSKVDIWNVGALIWDLFEDHHLFDGRGPNGDHSDAHLLAEMIAMLGPAPLNFLRKAPQSRKYWDSNGRWKGAIEVPQCSLEDSEEYLEGENKKMFMQFVRKMLRWDPEERQSAPELLTDPWLIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y951</accession>
    <name>B0Y951_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal specific transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_079660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y951"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079660"/>
    <dbReference type="HOGENOM" id="CLU_055334_2_0_1"/>
    <dbReference type="OrthoDB" id="3858188at2759"/>
    <dbReference type="PhylomeDB" id="B0Y951"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28507" checksum="E37722FF3FF06523" modified="2008-04-08" version="1">MSSLLQSRWAPKPNEHKTQGQVGPPAPASPSPGRRMLLSPAGELSRFMKIVARLKWKLPFLAEGYRLATLRTDSPEAVAHAEVMFKIDFHEYYALLERALVHLLGVFGIAVSAVGKGSGSNSVWSTHRYHANVLEALEDENCPLRSVFRKGNVFEQLRKAKELRNRWKTADLTEQEKKQESIWSSRREATMPLQNYDFDRMLADIFDGLEDGCRLAQEHVANLDKSNHTQAQADASNADWDFIVDAMDWEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9A9</accession>
    <name>B0Y9A9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_080370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080370"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_6_1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9A9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="573" mass="63461" checksum="FFCEEC947D7053CF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Z8</accession>
    <name>B0Y9Z8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Noc1p protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_082840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9Z8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082840"/>
    <dbReference type="HOGENOM" id="CLU_003115_0_0_1"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9Z8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="679" mass="74834" checksum="36848DA767FF8DEC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAC8</accession>
    <name>B0YAC8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_084220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAC8"/>
    <dbReference type="SMR" id="B0YAC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084220"/>
    <dbReference type="HOGENOM" id="CLU_009665_12_2_1"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="PhylomeDB" id="B0YAC8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="475" mass="53303" checksum="0BA90C21C106FB26" modified="2008-04-08" version="1">MTAKPPFKVIIVGGSIAGLTLAHCLSKAGIDYIVLEKRKHIAPQEGASIGILPHGGRILEQLGLFYLVEEQIEPLHTAHQYFPDGFAHTTKAPQVIYERFGLPLAFLERRRMLRALYDTLPDSSQVLVNKAVTSVEREVSDLMRVTTYDGSVYRGNLVVGADGVHSRVRAEMWRLATSQSPGVFPEHEMSAMAVEYACIFGISSSVPKLQPGEQVASFNNGRSYLTFPGKNGRVFWFLLLKLDRKYSYSNAPRFSSTDAEKRAERFADDHIWAGVNFRDLWKSKEVFSFVNLEEYLFQQWHWERIVCIGDSMHKMTPNTGQGANCAIEDAAALVNRLHRALKATPDGSSLSSGDIDDLLGEFNRARSRRVREIYQGSRMVVRLQARQNLFLKLLGRYYLPYRGEVAADAASKIIAPAEHLDFLPLATRSATGWHQFKPGQSKTLLIPFLYPVVAFSLCVLAWIGNDYLRNGVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAE1</accession>
    <name>B0YAE1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutral amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_084350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084350"/>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="PhylomeDB" id="B0YAE1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="44"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="463" mass="49747" checksum="1165D4FBEB70B1E7" modified="2008-04-08" version="1">MKAESQTQAQKPEDMDQKKEEPMPPVRQDAFGDEEFAEVKYKVLKWWQGGLLMVAETISLGILSLPAAVGTVGLAPGLAILISMGILASYNGYVIGQIKLRFPHITSMSDAGEVLLGPFGRELLNAAQILLLIFIMASHILTFTVAFNVMTGHATCSIVFGVVGAVISCLLSLPRTLEKVSWLSLVSFVSIFAAVMVTMVSIGIIKPTSTWAVAKHTDLVTAFGGVTNMVFAYASHNSFFTFIAELRDPREFPKALALLQSIDISLYVVAAVVIYYFAGDGVTSPALGSAGPLISKAAYGIALPTIVIAGVINGHIAAKAIYLRMFSGTDRIHKRDWIAVGSWIGIMAVLWTISWIIAEAIPVFNDLIGLIAALFLSWFTFGLPGVFWLYMNKGIWFLSRRKLFLTVVNVASVCIGLVVVSIYILGSPTVLGLIDQCALGLYASGVSINHNPAGSVFSCGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAF4</accession>
    <name>B0YAF4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_084480</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084480"/>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="PhylomeDB" id="B0YAF4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF9">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122546" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="379"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="537" mass="57505" checksum="F22C52082D8AD5A1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAY6</accession>
    <name>B0YAY6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_086270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086270"/>
    <dbReference type="HOGENOM" id="CLU_1937667_0_0_1"/>
    <dbReference type="OrthoDB" id="4511041at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="130" mass="14566" checksum="D61A56E31A6B1644" modified="2008-04-08" version="1">MTVDTMQKTREIPWADKERRICARYQRIWSVNNLLHAIPASKVGVVTYRYHDSRSRVSSILLISAEDFELDGPSIASYGLDSIIGAEMKNWSFKEVGLEFSFQNLLSPSLTFGGLAEVVSMHLGVILATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBW6</accession>
    <name>B0YBW6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_088070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088070"/>
    <dbReference type="HOGENOM" id="CLU_1396004_0_0_1"/>
    <dbReference type="OrthoDB" id="5292533at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="195" mass="21608" checksum="09B9C3A43D461ABA" modified="2008-04-08" version="1">MVSNNLQSSLTVCATIVTVPIGLATLALTQRGSNLLIPTSRKARTALRPSKGSCKWRLWVDLKDGPLYLHVDGERLPDVAYERPVVLGKILITSLSKWNEDSHAVGKLECLPLPKESLHVDLRVNLPFVFRAILLRGRGKQTTELSSRTFSINIVVLEVQIIKPDIVALHLGGTIQRTFTKDYVQRLLGGHPDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCB0</accession>
    <name>B0YCB0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_089550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCB0"/>
    <dbReference type="ESTHER" id="aspfu-q4wg73">
        <property type="family name" value="Canar_LipB"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089550"/>
    <dbReference type="HOGENOM" id="CLU_029537_0_1_1"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="PhylomeDB" id="B0YCB0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760600" evidence="1">
        <location>
            <begin position="24"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="463" mass="49259" checksum="31DBB983DB8B3ABD" modified="2008-04-08" version="1">MRWSSLLKAAVLYRAILSPLVSGAVIPRGAVPVASDLSLVSILSSAANDSSIESEARSIASLIASEIVSKIGKTEFSRSTKDAKSVQEAFDKIQSIFADGTPDFLKMTREILTVGLIPADILSFLNGYLNLDLNSIHNRNPSPKGQAIYPVKAPGDARYSVAENALRAAIHIPASFGYGKNGKKPVILVPGTATPAGTTYYFNFGKLGSAADADVVWLNIPQASLNDVQINSEYVAYAINYISAISESNVAVLSWSQGGLDTQWALKYWPSTRKVVDDFIAISPDFHGTVMRSLVCPWLAALACTPSLWQQGWNTEFIRTLRGGGGDSAYVPTTTIYSTFDEIVQPMSGSQASAILSDSRAVGVSNNHLQTICGGKPAGGVYTHEGVLYNPLAWALAVDALSHDGPGDPSRLDLDVVCGRVLPPQLGLDDLLGTEGLLLIALAEVLAYKPKTFGEPAIASYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCC8</accession>
    <name>B0YCC8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_089730</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089730"/>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="PhylomeDB" id="B0YCC8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP48259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="519" mass="58957" checksum="B01C38C1F5DE53F8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCD9</accession>
    <name>B0YCD9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RhoGAP and Fes/CIP4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_089840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCD9"/>
    <dbReference type="HOGENOM" id="CLU_008201_1_0_1"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="PhylomeDB" id="B0YCD9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000050">
        <property type="entry name" value="RhoGAP and Fes/CIP4 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000073">
        <property type="entry name" value="RhoGAP and Fes/CIP4 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="227"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="362"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="578"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="790" mass="87516" checksum="C9A8B1B21A75D226" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCN8</accession>
    <name>B0YCN8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COMPASS complex subunit Sdc1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_090850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCN8"/>
    <dbReference type="HOGENOM" id="CLU_160845_2_0_1"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="PhylomeDB" id="B0YCN8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="89" mass="9299" checksum="CB440C0443FB26BD" modified="2008-04-08" version="1">MGNGATPSSNTGAGNTPRAESDTPTAQVRPGGAPARAYMNEKIVPYLLEGMKSVVKEQPSDPLRVLGEFLIQKSNEVEGGAVSTKKSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCZ0</accession>
    <name>B0YCZ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase B14 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_093680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCZ0"/>
    <dbReference type="HOGENOM" id="CLU_153316_1_0_1"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="PhylomeDB" id="B0YCZ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="82" mass="9756" checksum="C28BB79CA664A59A" modified="2008-04-08" version="1">MYSLNLPVSAIRTKIRQEFEKHRYVQQLGVVDVLLFQSHAEYQETLNYWKQLSHVMKYFRPEEDPGARLPPNFISGFLEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDI1</accession>
    <name>B0YDI1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_095660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095660"/>
    <dbReference type="HOGENOM" id="CLU_096905_1_0_1"/>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="PhylomeDB" id="B0YDI1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="168" mass="18512" checksum="BDBB5E38991F64A7" modified="2008-04-08" version="1">MSVSASIPDTSLGLTSSEIQILRQQQQIALQNGHTGNGVSRGRGTGRTSNSSSRAASAASSHGRLLLDPMSLRALSHQLDGLQEQIRSRIGYLEEQMQLSIQNSYDRAGNVIRNVDAEIARTRSILASIDDLENELAKIGHIREIVKAYRGRIESLDQRIDQAARRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDJ2</accession>
    <name>B0YDJ2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_095780</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDJ2"/>
    <dbReference type="SMR" id="B0YDJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095780"/>
    <dbReference type="HOGENOM" id="CLU_025144_2_1_1"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="PhylomeDB" id="B0YDJ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="552"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP47726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="597" mass="65209" checksum="467E4F5D0A5C00AD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDT3</accession>
    <name>ABNC_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable arabinan endo-1,5-alpha-L-arabinosidase C</fullName>
            <ecNumber>3.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Endo-1,5-alpha-L-arabinanase C</fullName>
            <shortName>ABN C</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">abnC</name>
        <name type="ORF">AFUB_096700</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EDP47817" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47817.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDT3"/>
    <dbReference type="SMR" id="B0YDT3"/>
    <dbReference type="GlyCosmos" id="B0YDT3">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="PhylomeDB" id="B0YDT3"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF7">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394633" description="Probable arabinan endo-1,5-alpha-L-arabinosidase C">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P94522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="321" mass="35089" checksum="7D48094623F785F1" modified="2010-06-15" version="2" precursor="true">MYLYTLILLFLASANVNAYANPGACSGNCWTHDPGLYQRKSDGKYFRFATGGGIHIASADSLEGPWTDDGYVLPSGSIIDLDGKTNLWAPDLHYHDGTYYLYYAVSSLGSQNSAIGVATSKTMEAGSWTDHGTTGIESTPSSPYNTIDANWIAVGGNQYVNFGSYWNNLFQVEMENGLKVKSGATPHQIAYNASGIHRQEAAFMFERNNYFYLTFSGGIALGYNDTWPAPGEEYFIAVCRSTSATGGFVDKNGVSCLNSGGSLLLSSHDFVYGPGGQGILQDSSKGFVLYYHYADTRIGKAVEDYQFGWNQLKWENDWPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDZ4</accession>
    <name>B0YDZ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_097320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097320"/>
    <dbReference type="HOGENOM" id="CLU_007091_3_2_1"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="PhylomeDB" id="B0YDZ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="799" mass="89714" checksum="9358A151B5B7B3E8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE87</accession>
    <name>B0YE87_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_098310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098310"/>
    <dbReference type="HOGENOM" id="CLU_071095_0_0_1"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="PhylomeDB" id="B0YE87"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760959" description="ER membrane protein complex subunit 10" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22595" checksum="A6396E20E6A72D73" modified="2008-04-08" version="1">MHFSQVILPFLSLFSSRAFAASPSSAQAQSADILYWPVASSQPSVLARISYDPASLASDVVVYSPPRITDLEGGRNLEADAQDLVRVGLFTFTPNNPKHWVGSLTSLSLLAENEDQKPTLRLHLGPSGEVYHVSLAASPPSAATSSSKGLNIELLSSEVGPRPHLNRPVDVGPDGKSPEEVIEKTFFQKYWWVFLIITFLAMSGSAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEA9</accession>
    <name>B0YEA9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_098530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098530"/>
    <dbReference type="HOGENOM" id="CLU_062297_0_0_1"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="PhylomeDB" id="B0YEA9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="270" mass="30062" checksum="E3E4ECEF456A4B95" modified="2008-04-08" version="1">MECFSMHITQSILRCRIRPLIFGHSRATTKPSLPLGPISSLTRQYAFTAPSHRRTLHDDSLASLEDSTRSQAHPLSGYYYDILSSKSPYRSHAPTSHPAAEKPTPATTVKPQSPEEKMSIVFGSRLAGPGRASRYNPGTLPPESQWKTINGVAIPPRPEEPDNCCMSGCVHCVWDDYRDEMEEWASRVEKAKAKGTTQKATADMRQTPRAEVDSASRSMDDDGGGSETNWPVSYEADDLFANIPVGIREFMKTEKKLKEKHQHEKNKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEB0</accession>
    <name>B0YEB0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_098540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098540"/>
    <dbReference type="HOGENOM" id="CLU_029857_1_0_1"/>
    <dbReference type="OrthoDB" id="4160836at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="626" mass="69012" checksum="7F7591AA13D8D6AD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEN0</accession>
    <name>B0YEN0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_099750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099750"/>
    <dbReference type="HOGENOM" id="CLU_072339_0_0_1"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="265" mass="29432" checksum="590307D470F78477" modified="2008-04-08" version="1">MVNVIWSHVLLRRKRYLLPEARRNPPTAGLPTTDPPTSNSNSNNHPTTALPMTSHPRIHPRTTAPRTERPPYERPPPERSPSSFDPSRPRYEGPPYNSSSPAPSAQPPAIPPPPLPLGWVQEWEPNLRRAYFVETATGRSQWETPMQDSEHARGLSGPPPESASYYASPPPPPPPQDGGYYPPPGEYPPPEEKKKKSSGMGKIIAGGVAGVALGAAGMALWEHEKREDEEQEELKERVERLEEEQNHSSSSSDHERAHSPDVDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEV8</accession>
    <name>B0YEV8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_100640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100640"/>
    <dbReference type="HOGENOM" id="CLU_2885372_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="63" mass="7202" checksum="27A20325318B85AC" modified="2008-04-08" version="1">MQWLFSRQDLTQLTVRAYWTAPSPPCRVAVIDFTITKYPSDAIYTYMTTSSVIPSSLQALTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEY7</accession>
    <name>B0YEY7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_100950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100950"/>
    <dbReference type="HOGENOM" id="CLU_1712838_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16715" checksum="23946C249A02FC94" modified="2008-04-08" version="1">MAESLGAAASIVGIVSLAGQICSGVQQLYAFVDSVKQAPSDFQNIKNDMLLIERLVGRMAEDCTGLPEYLDNDILKSSLELCLSRITRLLTIIQSLDPSSQKNRPINFIKATVKKARVADCGHRNLFLLVLLTRPAQDITPSSSVTRAATRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF88</accession>
    <name>B0YF88_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_101940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101940"/>
    <dbReference type="HOGENOM" id="CLU_440132_0_0_1"/>
    <dbReference type="OrthoDB" id="5278911at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="722" mass="80709" checksum="612726408380025E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJN3</accession>
    <name>H9CJN3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase chain 4</fullName>
            <ecNumber evidence="7">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_m0060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="9"/>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353052.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJN3"/>
    <dbReference type="GeneID" id="11948043"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="8">
        <location>
            <begin position="132"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFE02833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="488" mass="54240" checksum="0B48293DA3102F75" modified="2013-02-06" version="1">MSLLLLLIPLIGIGLVTIEANYGLSLINNIRIKSIALITSIVNLVVSLIMFILFDFSSKQFQFIEEHYQISYFDIYLGVDGLSIYFVLLTTIIMPIAILSNWNSIQSQNVLSFVVIMLLLETLLLAVFLVLDVLLFYIFFESILPPLFLLIGLFGSSNKVRASFYLFLYTLLGSLFMLLSIIAMSSIMGTTDFDALSKANFSYVTQLFLFYGIFIAFAVKTPVIFLNTWLLKAHVESPLSGSIILAGIVLKLSLYGIFRLMLPLLPKASLNYTYIIYVIGVITIIYASFSTLRTIDIKELIAYSSVSHAAVYLIGAFSNTIQGIEGSILLGLAHGFVSSGLFICAGGVLYDRSSTRLITYYRGMAQVMPIFSVLFFILGLGNSGTPLTLNFLGEFMSLYGVFERMPILGVLASTSIVFSAAYTIFMYNRIVFGGSYSIYFVENIGDVTRREFIMLLVFVILTVLFGIYPAPILDGLHYSVSSLIYSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM05</accession>
    <name>B0XM05_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_001820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001820"/>
    <dbReference type="HOGENOM" id="CLU_117291_2_2_1"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="PhylomeDB" id="B0XM05"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="161" mass="18340" checksum="5149DC10183FA0C1" modified="2008-04-08" version="1">MGAVRKIKTKRRTRYDIQECTHRAIGALEGPIALTLLVSCRDYDQVRADIDSPKHLTQYKATKDAEDLPGLGKHYCVECSKWFESEYNLVAHTKGKNHKRRSVIMDSANVFLDRSRLTQGCLNRLRLLREEPHSQKIAEAAVGLSTDNGLRQQETVVDMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMN1</accession>
    <name>B0XMN1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_003330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003330"/>
    <dbReference type="HOGENOM" id="CLU_047018_0_0_1"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000391">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="271"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="425" mass="46688" checksum="A0ED4C3DC5BF19B5" modified="2008-04-08" version="1">MPSRDRGRARARASDEEFVLFLQGIPAHCRWQELKDMVRQTALHIRQAVVYDDQHGFPTGLGQIIVKNEDEAWRTYHRLSTNGWDGQSLVVTLARTSSPTRPVAGPTKSPSCVIPPAYVAGYSTPPRVAQNLAIPPSPISPDTPLVSMTPAAAPAPAYQGQGPEYAPVINPMAMPPPPPPYLQPFIPIFTDQLPSIPHSPSLAHSFCDTLAFAMLPTYPIPPLHLPHPDHSFTNTNGNNSNTNPRPRTTFHPRKPSSSDQTQQNPRFSPRRTIFIQNLSPTTTPHDLTLFLQDAGTIEQCEMPLNPDTGRCKGFARVTFRSADEAKRAIALYNTAFFLGAKIRVKIDRSGYFPSGQGQGYPARDGYYLPNRPNQPERKSVENDITPAPGTVDRKSSGPQRVTERDRCQPLVVNGSGLGNKTAVAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMV6</accession>
    <name>MPH1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase mph1</fullName>
            <ecNumber evidence="1">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA 3'-5' helicase mph1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">FANCM-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mph1</name>
        <name type="ORF">AFUB_003450</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="1"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMV6"/>
    <dbReference type="SMR" id="B0XMV6"/>
    <dbReference type="EnsemblFungi" id="EDP55648">
        <property type="protein sequence ID" value="EDP55648"/>
        <property type="gene ID" value="AFUB_003450"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003450"/>
    <dbReference type="HOGENOM" id="CLU_002513_0_0_1"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="PhylomeDB" id="B0XMV6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000333365" description="ATP-dependent DNA helicase mph1">
        <location>
            <begin position="1"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="296"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="634"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="824"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box" evidence="3">
        <location>
            <begin position="412"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="309"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9UT23"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1101" mass="123391" checksum="8B8CF03928335BA3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN21</accession>
    <name>B0XN21_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2 transcription factor (Sfp1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_014300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014300"/>
    <dbReference type="HOGENOM" id="CLU_013026_2_1_1"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="PhylomeDB" id="B0XN21"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000676">
        <property type="entry name" value="C2H2 transcription factor (Sfp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="546"/>
            <end position="576"/>
        </location>
    </feature>
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            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
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            <end position="402"/>
        </location>
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        </location>
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            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="306"/>
        </location>
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        </location>
    </feature>
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            <end position="374"/>
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            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56711.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="672" mass="72104" checksum="E9EC30F22A880318" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN26</accession>
    <name>B0XN26_ASPFC</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        <name evidence="13" type="ORF">AFUB_014350</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </reference>
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        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
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        </reaction>
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    <dbReference type="OrthoDB" id="193931at2759"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="309"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="598"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="834"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1080"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
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        <location>
            <begin position="742"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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            <end position="845"/>
        </location>
    </feature>
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        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
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        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
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        <location>
            <begin position="1095"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1135" mass="123675" checksum="D8E18D4E455A7098" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNH8</accession>
    <name>B0XNH8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase TilA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_015200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNH8"/>
    <dbReference type="SMR" id="B0XNH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015200"/>
    <dbReference type="HOGENOM" id="CLU_006504_5_0_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="B0XNH8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042440">
        <property type="term" value="P:pigment metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000061">
        <property type="entry name" value="Laccase TilA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760007" evidence="7">
        <location>
            <begin position="25"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="33"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="174"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="462"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="596" mass="65546" checksum="44AFEFFACEAC01FD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ53</accession>
    <name>B0XQ53_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF6 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_008730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008730"/>
    <dbReference type="HOGENOM" id="CLU_032828_4_3_1"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ53"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="74"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="426" mass="46164" checksum="889963E178B43115" modified="2008-04-08" version="1">MASSQRQYNTLPSSGSIAAPPLSENGSNVYEDDIRRPLLGSSSSTDLDGNGKKGSQSWLRAVYGEGKEIWLQGKGMILVTLAQFFGASMNVMTQILELDSGLHPFQILFARMSVTVVASYLYMWYTKVPHPFGTRPVLGLLIFRAMGGFFGVYSIYYAVQYLPLSEATVLTFLAPILCCYACSLFIPNETFTRRQQLAALVSMVGVVLIARPFSSSAMPPNPEKLEGRKPGTTDEFQHIVAILAMMVGVLGSTCAYTSIRIIGQRCHPLVSVTYFSLFTTVMSFLAMLLVPSVPFKLPETGLEWTLIVGLGVCGFLLQFLLTAGLSYVPPPPRRSQRVSGGAGSECKPARSSSGSRATSMIYTQMLFALFYDKVVWGNTLSPLSWAGSALIVGSALYVALVRDGKKNAAAAVAVDETAEEEREPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQA8</accession>
    <name>B0XQA8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_009300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQA8"/>
    <dbReference type="HOGENOM" id="CLU_072439_0_0_1"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="PhylomeDB" id="B0XQA8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000011">
        <property type="entry name" value="37S ribosomal protein S18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="205" mass="23033" checksum="86E718E1CBACFC8A" modified="2008-04-08" version="1">MRPFSTTMSPSSSAKEKTREIERQILNPNSEQTTDDNSPLSAITRMMQGEKARASQAVSRDYSRMAESLEAEMIKYPYADRSPPHHLHVYAHKHNTLLTLTQPNGNPMLSMSCGHLGFRKGGRSGYDPAYQLTSHVFGQIQERGFLMDIKRLEIVFQGFGQGREAFTKVLLGSEGKNIRGLVSRVTDSTRIKFGGTRSRKVRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQF1</accession>
    <name>B0XQF1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Formin binding protein (FNB3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_009730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009730"/>
    <dbReference type="HOGENOM" id="CLU_005825_1_0_1"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="PhylomeDB" id="B0XQF1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000027">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000032">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000033">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000034">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000078">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000090">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="373"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="510"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="345"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="745"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="790" mass="93728" checksum="862941B16E2A972A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQN1</accession>
    <name>B0XQN1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_010550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQN1"/>
    <dbReference type="HOGENOM" id="CLU_041798_4_0_1"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="PhylomeDB" id="B0XQN1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2020.20:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="325" mass="34722" checksum="F18F13F1754206FC" modified="2008-04-08" version="1">MVPSDGTFTPYQPAGKDAPTNGRIFVLKFSSSSQRYLFWLQSKSQHERGDPSWFSPRDLRLGEIVNELLQGEEVDVAHAIANLPRGGPSGSGDDDETMEDVEGVDHNPNHNHGGSGGAGPDATGGDIREEGEEAREGGADGGRAVAADSNPSSVVQSFLRSLQGNQNQSQDPDRPFTTLQDLLSPSSTIPFLDSADDRTVDNLLSYLPPTLLLLAQESEDVSLAETDPEIVEAAMLSLDLSQKKGILRKVLHSPQFSQSLASLTVAIRDGGLPSISEALKIPVENGGFMHRGGVPLGGGDAVEAFLRGVRDHVKESDQENLMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRK7</accession>
    <name>B0XRK7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_013020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013020"/>
    <dbReference type="HOGENOM" id="CLU_120062_1_0_1"/>
    <dbReference type="OrthoDB" id="3945172at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="154" mass="16781" checksum="E7A7A634248F6B35" modified="2008-04-08" version="1">MPSSPRLQTTTSKLQSMLIPRPPRVTLLPLQSVWQPARLPTPGNVRARFNSSLGQEWKGSSTDDHAVERSKGKRDITDPQTESSASGLKEKKESAGVADGSKQAAVTEREGLKQERQAKKEHPKAPEPIIGMNDERGEVSATCPFPLETVIKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRS3</accession>
    <name>B0XRS3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZIP metal ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_024650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024650"/>
    <dbReference type="HOGENOM" id="CLU_023518_1_0_1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="PhylomeDB" id="B0XRS3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="508" mass="54616" checksum="29E5B1849CFABDBE" modified="2008-04-08" version="1">MAANSDLRGWLMSGVSGTVRRFSRRKDFQIANSNGFLSASLCLSAGVMLFTSLYSMLPTSKEYLTRAGFSPRAAACTLIGLFLAGVIAIRLVSAFIHQRIPSHVVDCAHSHQPNTQDPERGEVGRQEQLASAPNQANGSTERTPLLLQSKPPSRKSMPGAVERPALEPLRSRLTRRINQLMGGVKTQCDENGPCYGFSQTCGLECTKILTNTQMASVVEEMPRPSLITHHSIGVQLDSERVGFGEGAGPGLLPQSHDSTEDVSGQSDASNSQKNQSSASSLRTGLEVYPHKSSEDQNDSTKEPRAASAQQQQHHHHVPQNAFLSIGLQTSLAIALHKLPEGFITYATNHASPTLGMTVFVALFIHNISEGFAMALPLYLALNSRWKAMFWSSLLGGISQPAGAALAALWIWGARKAGHHDETTGPSWGVYGGMFAATAGIMTSVGLQLFSEGLGLTHRRGFGVGFAIAGMGLMGLSFALTAAGIVYYRVFFDDCLSALRVMIVLFINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS87</accession>
    <name>B0XS87_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_026320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS87"/>
    <dbReference type="HOGENOM" id="CLU_001265_51_3_1"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="PhylomeDB" id="B0XS87"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="15"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="468" mass="51143" checksum="6EBA09EEA027A239" modified="2008-04-08" version="1">MFCSSNKGHKRPPWLLRIRSSTAFIIATDYFLYAMIVPVMPTALVDRAGVPYIEREYWVSVLLMCEAVVAFICCPIFGYLVDIAPTRQFPYLFGLILLGASMGMLAVAHTVWLFVVARLLQGGATAMVAVAGLALMTDSVSFDNLGQTIGYLGSSIALGFLLGPLLGGLVYNAAGYNAVFAMAFAIIGVDFVMRVAVIEKKVARAYLSDSPEENPREEYPQRPPQISETATGWRNIALLRIASQPRVVISSFALLVQGILYSAFDSTIPVFVEDRFGWSPFGAGIAFLPSAITALFEPYFGSISDRYGARLVTFTGFLLLSPPLITLRFVESNTTPHIILLLSLLTLIGLFINACVPALYVETQQVLEEMERARPGIFGKRGAVAQAFGIQTMSSFMGMFLGPLWGGFIEYQFGWNTMAWTLGLLAAVTAVPMLWLSNGAPGEVVEGMERERERLLAGERREVADGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSH9</accession>
    <name>B0XSH9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase, GNAT family family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_027250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSH9"/>
    <dbReference type="HOGENOM" id="CLU_061829_1_0_1"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="PhylomeDB" id="B0XSH9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000141">
        <property type="entry name" value="Acetyltransferase, GNAT family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="143"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="291" mass="32378" checksum="27E68957B361AA0E" modified="2008-04-08" version="1">MAEPTHQTEAKKTMTGFKPLSNAEDYSLPATASDLSPRAEAAVANGLSLETADEDHEEVDEDYVAVDPDEISDFSYWLRRPPVHHRTKLDELHPFVQTLTVSNVDDCVEVENAFPENERCSREKFIYRLTKCPELSLGLFTIPIVPKGQPKPRPTLIGHIVATRTSTQLVTDNAMKLPPNWRSARVVTENGETIGHDEYGSTIAIHSLAVLPEHQGKQVGSTLMKSYIQRIREAAIAERISIIAHDHLVPFYQSFGFENRGPSKCQFGGGGWTDLVSSFLTDYKVYGLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSR8</accession>
    <name>B0XSR8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_017360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017360"/>
    <dbReference type="HOGENOM" id="CLU_2249488_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="104" mass="11846" checksum="637799D57250B585" modified="2008-04-08" version="1">MEMQRAKVKSFHSTPGSNLMGSEYALFEAERTERVEERSTGIWDPGAQIAQPEHNCGRQFEGKLMDGEVIGLINASFFKVVHIPETFQYRSYMDIYITASTDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSW4</accession>
    <name>B0XSW4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_028020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    </organism>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
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        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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    </dbReference>
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    </dbReference>
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            <end position="44"/>
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            <end position="123"/>
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            <end position="157"/>
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            <end position="419"/>
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            <end position="825"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1051" mass="113940" checksum="0DC40B4F8F50F850" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSY8</accession>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
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                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    </feature>
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            <end position="345"/>
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        <location>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EDP54766.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT31</accession>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
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                <person name="Sundaram J.P."/>
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                <person name="Wortman J.R."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <location>
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            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="364" mass="41078" checksum="85B23DD80B7A7971" modified="2008-04-08" version="1">MADFSSIPIIDFGRLQDPSTKEETLVQLREAIFLVGFLYLTNHGMEEIIKKAHATLPDLFALPTEVKEKCNMINSPSFVGYTRLGAETTAKQTDWREQFDFGTPGMKQWTPEDPIWQRLEGNSQYPDYPGVRELVEEYIAESAQLSKKFMRHVAECLSLPPTTFEAFRGNMDRLKFIKYPQSPPGSQGVGPHKDSSGLFTFLSQDDTGGLQVLNKKGEWIDAPPIEGSLVVNIQQGFEAITGGVCTATTHRVIVSLCFTLYLGHRSDVEKAPTSKTRYSIPYFSAVRMDLTLAQLKESAAHIVQRIPASDDRKKRAVDVPSEFLSPLYSCFGEAYMRNRILSHPDVGQKWYPELYEKYSKQVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT52</accession>
    <name>B0XT52_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_018050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018050"/>
    <dbReference type="HOGENOM" id="CLU_096188_0_0_1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="PhylomeDB" id="B0XT52"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="90"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="188" mass="20510" checksum="3E97B4FB63BE66B0" modified="2008-04-08" version="1">MSTNPGQISPLAGITRYITTHNPSGQAIIHSEQPVIWGSYEGGALGMGVAYTTSEFPANLNNEVDIKTHEKLMEKNTLGLVNPGGTVCRFVDFKPGGEPFMHRTQSLDYGIVLQGEIEMILDSGEKRTLKAGDIAVQRGTKHAWRNPSEVEWSRMVFMLQDIQPIVIGGVVLEEDVSGSDEIKPSQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTC2</accession>
    <name>B0XTC2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_028910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028910"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="PhylomeDB" id="B0XTC2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="12"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="365" mass="39073" checksum="B333C93DE931A47B" modified="2008-04-08" version="1">MSKAIFMSQVDGKPGQVYYPLSVQTLPLPTPQGRELLVKMTAASLNHRDVFLRQHLYPGATFDVPLGADGVGVVVGTGPDVTNPERWQGKRVILNPGTGWNDSPDGPEDPKGYRIMGGTKIYNKGTLQEYLTIEESEVEEAPEHLSDAEAAALPLTGLTGWRALVVKAGERNSGKGAAVLITGIGGGVALIVLRFAVARGADVYVTSSSEEKIQKAVALGARGGVNYKEEGWEKKLLGMLPSGKQNFDAVIDGAGGDSVEKATKLLKAGGVLSVYGMTVSPKMPFLMQAVLKNIDVRGSTMGSRKEFKEMVDFVKANKIHPVISRVVQTDLGDIEGLDRLFQDMKEGKQFGKLVIEFGKSSGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTE7</accession>
    <name>B0XTE7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_029150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029150"/>
    <dbReference type="HOGENOM" id="CLU_012923_4_2_1"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="PhylomeDB" id="B0XTE7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="66451" checksum="B8D921C8C848A6A7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTJ2</accession>
    <name>B0XTJ2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_018770</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018770"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_3_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="PhylomeDB" id="B0XTJ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000022">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000024">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="73"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="414"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="498"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP53833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="793" mass="89257" checksum="1D4A4346C0A99138" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTL2</accession>
    <name>B0XTL2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase II transcription elongation factor Rtf1p, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_018990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018990"/>
    <dbReference type="HOGENOM" id="CLU_019525_0_0_1"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="PhylomeDB" id="B0XTL2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000005">
        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="265"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="607" mass="67792" checksum="49BA81323110D8E0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTN3</accession>
    <name>B0XTN3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase 49 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_029340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029340"/>
    <dbReference type="HOGENOM" id="CLU_015134_1_1_1"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="PhylomeDB" id="B0XTN3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="200"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="470" mass="52855" checksum="231CB8DB63F16402" modified="2008-04-08" version="1">MAASFARLAGSAPKKLCLRPSTFARNTRSISTTLPRRYAEPTSYQATRLVPTDSTFTHLANKATAESEAASNLESQAEGVDRKIRHYTVNFGPQHPAAHGVLRLILELNGEEIVRADPHVGLLHRGTEKLIEYKTYMQALPYFDRLDYVSMMTNEQCFSLAVEKLLNIEIPERAKWIRTMFGEITRILNHLMSVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVSQDLPLGLLDDIYQWATQFGDRIDETEELLTDNRIWKARTQGVGVVTAADAINMSFTGVMLRGSGVPWDIRKSQPYDAYDQVEFDVPVGVNGDCYDRYLCRMEEFRQSLRIIHQCLNKMPAGPVRVEDYKISPPPRAAMKENMEALIHHFLLFTKGYAVPPGETYSAIEAPKGEMGVYLVSDGSERPYRCKIRAPGFAHLSGFDQISRGHLLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU27</accession>
    <name>B0XU27_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase, FAD-binding, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_030100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030100"/>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="PhylomeDB" id="B0XU27"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758346" evidence="5">
        <location>
            <begin position="20"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="473" mass="50494" checksum="5FA45C36DE189F58" modified="2008-04-08" version="1">MNVGSILFAIAILPSFALATSTCVGRLSFLVSWLTDSCAVSGFDEHPRPQATSAEDVSKALRVLVPKACKFAVRSGGHGAIAGIANIQDGVTIDLSALNWVIPSADRSLVSVGPGQRWGRVYAALDRLGLSVPGGRDSPVGVGGTTLGGGFGYFATEAGFACDSVVEFQVVLANGRIVNATKDNEHDLWLALKGGANNFGIVTNFIFRTFPLGRVWGGHIYYPVSTLDQQLDAFYRFTSDPNYDVKAGLIHNFAFTPATGPLLTNLLAYASPEENPAPFRSFTSIQPQIMASTKVMTLEALAEEGGSLSPNSRQQLTFAVTFENNLDLLTQVFDIWNASTADVSAIPSIQWSLSIEPIVPAIAHQSAIKGGNVLGLDVPRQGLVLALLSATFNHSQEYPIVRAAAEKLSNNIISAAKAACAYNPYIDLNHAAPWQDPIASYGDRIQAFLRQTAGKYDPQGVFQRLCPGGFKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU79</accession>
    <name>B0XU79_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_030630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030630"/>
    <dbReference type="HOGENOM" id="CLU_015166_10_3_1"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="PhylomeDB" id="B0XU79"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="238"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP55002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="341" mass="37046" checksum="51B6F2A0FBDB3F3B" modified="2008-04-08" version="1">MSAGGEHLKDEVRLALKDPADSDIEHSIQIITREKGTRRQVVLSGGIAGLVSRFCVAPLDVVKIRLQLQIHSLSDPASHHDVVGPIYKGTLSTMRTIIKQEGITGLWKGNIPAELMYVCYGALQFTAYRTTTQILAQLDPHRLPPALESFVSGAVAGGLATASTYPLDLLRTRFAAQGTERIYTSLLASVRDIARSEGPAGFFRGCSAAVGQIVPYMGLFFATYESLRPVLSGLENMPFGSGDAAAGVIASVLAKSGVFPLDLVRKRLQVQGPTRTLYVHRNIPEYRGVFSTIAMIVRTQGVRGLYRGLTVSLIKAAPASAITMWTYERSLKLLRDFRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUI7</accession>
    <name>B0XUI7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_031030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031030"/>
    <dbReference type="HOGENOM" id="CLU_017518_1_0_1"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="PhylomeDB" id="B0XUI7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF3">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP55042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="613" mass="66577" checksum="F062F443EDD23C76" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV99</accession>
    <name>B0XV99_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 20">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">AFUB_032370</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 20">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17 20">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 20"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV99"/>
    <dbReference type="SMR" id="B0XV99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032370"/>
    <dbReference type="HOGENOM" id="CLU_028491_2_0_1"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="PhylomeDB" id="B0XV99"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 18 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="24">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP55174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="418" mass="46205" checksum="F9041F65FEFBF0DA" modified="2008-04-08" version="1">MEQTFDLPDSTDWLETPLSLVSPLESSLRCQVCKDFFDNPVITSCSHTFCSLCIRRCLSTEGKCPACRSSDQELKLRRNWAVQELVEAFQNARPSMLELARKAANSRLDGGYVTGQPAAKKRKVDQEDGPDASGSEGIRTRSQSRRGNSQAEPVVVDAIEDDQDKEYIPEDGLVACPICGRRMKNEAVFQHLDICTGDPAPLKQASFGSLQPMSPASRKSKDVTDKPPERLPTINYSLLKDNVLRKKLKDLGIPNWGPRPLLQRRHTEWMNLWNANCDSKAPKSKRELLHELAVWERTQGGHAAPSSESSNTVMRKDFDAAAWSNNHGDEFKRLIANARKRKDAVIRTTIPQAAPARDGTSTASAPEQSTEMSTPPEVAERLQTQTVPEGTSVATIAENETGTIQTPNITQVVSSPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVC6</accession>
    <name>B0XVC6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_032650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032650"/>
    <dbReference type="HOGENOM" id="CLU_040204_1_0_1"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="PhylomeDB" id="B0XVC6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="66"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="339" mass="38547" checksum="B328D0D50EF7426E" modified="2008-04-08" version="1">MSSGPNGARRIASVLRPSIVDSRVCRSCQETLVRRNYASTAAPSSASETVSTPASTFPVVKPTHIIKAGVALSRPPQITRDLTPFEKAYFFYQKRLNERLALPFTKYFYFKRGTPADEDWKRKIRERQTPARDIGKYNAYSKEAWNDELLVGAVESEPEHQIEMLVRDAESTANATSQDTSKKEEIPRPFPRVTEADQKNDQRSLNRALQRTLYLLVQTKEGYWKLPSSPVETGESLRVAAERTLEQSAGVNMNTWMVGYHPVGHHVYNFRHPKTDPATGQQWLGEKTFFIKGRIMAGQADLSANVQGLQDFKWLAKEEIAKFVLPQYYSNIKNMLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW17</accession>
    <name>B0XW17_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Neutral protease 2</fullName>
            <ecNumber evidence="16">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_033760</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="16"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033760"/>
    <dbReference type="HOGENOM" id="CLU_091045_0_0_1"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="PhylomeDB" id="B0XW17"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF7">
        <property type="entry name" value="NEUTRAL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122522" description="Neutral protease 2" evidence="16">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP55310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="222" mass="24155" checksum="E7DB48041E733735" modified="2008-04-08" version="1">MHFFQALVALPLIAGAVASPLDTRATLENCNDEGVRAINNALTQAAEMANSGASLIRSESDYSYSLFQSFFKTNDAQARNHVADVLDTIATEATNGNQGVVTYYCTPEGIECTNSHSFTMTAYGDTDGTYGRVRTCPAYFTDFPAWSNICSVLDQATSSLHELAHTKGIYGPETYGYDAVHSLSSASALENAESYAFFSKCMVSYYFQVKYALLILFSSSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW41</accession>
    <name>B0XW41_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_023490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023490"/>
    <dbReference type="HOGENOM" id="CLU_089876_12_0_1"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="PhylomeDB" id="B0XW41"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="145" mass="15809" checksum="F39D62A0A6B30D90" modified="2008-04-08" version="1">MNTELHQVLNVWDRIRVNSPIYAFLLNDVEIYGAQKGKINARVRVTSHHLNSKNTLHGAFSACVTDWAGGLAIASCGHDSTGVSTDIHVNYMSTATTGDWLEIEGCADKVGKTLAFTTVIISKKSEEGKMTIVAKGSHTKYLRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW90</accession>
    <name>B0XW90_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_023980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000504_2_0_1"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="PhylomeDB" id="B0XW90"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043008">
        <property type="term" value="F:ATP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170011">
        <property type="term" value="F:stalled ribosome sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904689">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990611">
        <property type="term" value="P:regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006448">
        <property type="term" value="P:regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:002031">
        <property type="entry name" value="Translational activator, putative (AFU_orthologue AFUA_2G07960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1538"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1681"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1998"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2669"/>
            <end position="2711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2711" mass="296218" checksum="651433D0C47C0DA6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWE7</accession>
    <name>B0XWE7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_035640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035640"/>
    <dbReference type="HOGENOM" id="CLU_1510246_0_0_1"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="PhylomeDB" id="B0XWE7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="178" mass="19457" checksum="0516ED40DCFBCA1A" modified="2008-04-08" version="1">MLTVYSAQLSLMHPGMETKQPVAVTLTTPKAQELFTFLRSSYIDERSGLPRGIPQHEMRTDDIDGFPFYRPEPPKILGRLPELKPAVLYIFGKSSDFSSPDARQEKLQTTGIGVGGSGGASRGWVQEVVLPCGHLVPMDCVTETAQASADLIGSELLFGNRKLRSSRKLGEVSHIVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWH2</accession>
    <name>B0XWH2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_035910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035910"/>
    <dbReference type="HOGENOM" id="CLU_097635_0_0_1"/>
    <dbReference type="OrthoDB" id="4510598at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="184" mass="19042" checksum="30033396E987DBBE" modified="2008-04-08" version="1">MCYYMPNKPPCTCTYLQLIQPCSQVRIFAVPGSPTPLIQVCPIRYIARGVGQRFCALCSRTADFGGSTSTAAVGLVGYPEQQGFGGSQLEPSSRQSQQQATPIDPCLVGGGISIGDLLLPMGEESRGELGTAGDAERRDEAGQSAQGSSSSELSIQSLVVQDEAGGGLVEDAVSGAQVAKVPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWW1</accession>
    <name>B0XWW1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_036610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036610"/>
    <dbReference type="HOGENOM" id="CLU_2249519_0_0_1"/>
    <dbReference type="OrthoDB" id="4522394at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="107" mass="12302" checksum="D00EE9E4616D34AF" modified="2008-04-08" version="1">MPSKGCHSNSLPEARGLKYDESDMALFHAKLSYHSTIEERMASKDTNLASISEHQARILKRWEMLKQVEKEMADKGKCLSPAEKKQLAQYEWRYKRLEELATKTTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX21</accession>
    <name>B0XX21_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1993 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_047440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047440"/>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="PhylomeDB" id="B0XX21"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19575" checksum="68E752F13BB9CA1D" modified="2008-04-08" version="1">MTSSIYTYTVPTYLKGLDTLTFMLKKAEEYAKENNIPLSEFAEARLYPDMLPLSFQVQCVSNTSKNSVARLSGTDIVPMEDNEKTFEEFYDRINRTIDVIKAVDPKLFEGREHTEFSVKLGSYESTFTGESYVNRFGLPNFFFHLNIAYAILRSKGVPLGKFDYLKYFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX33</accession>
    <name>B0XX33_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-dependent oxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_047560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047560"/>
    <dbReference type="HOGENOM" id="CLU_018354_0_1_1"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="PhylomeDB" id="B0XX33"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760538" evidence="6">
        <location>
            <begin position="22"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="72"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="507" mass="55026" checksum="D2F6BA5CFBF212DE" modified="2008-04-08" version="1">MRWLKIEAVAALAASAVPAFCLSVPVARDLRGICPRGDDDLKELGAKLSRTGKIYFPGSTEFEQASTRWSVLETPTVNVVVVPGTENDVVETVKYANKKNLPFLAYNGVHGAITTLGRMDHGIEIYLNQLSGVEISKDGKTAKIGGGTKSKLVTDQLWAAGKQTVTGTCECVSYLGPALGGGHGWLQGHHGLVADQFVSANIVLANGSLKTIDAKSDLWWALNGAGHNFGIVTSVTTKIYDIQHADWAIDTLIFSGDKVEAVYQAANEHLLKNGTQPVDLINWSYWLNIPTADPNNPVILFYIIQEGVKTVDPAYTKPFHDIGPLSAEAIGGSYTDLAGWTGIATTSPPCQKAGLVNPRFPIYLREYNVPAQKTAYDIFAAATRGSSAFNNSIFMFEGYSTQGVKAINSKSSAFAFRNENLLAAPLVTYAPAGPERDNDAKQLGNQLRQILFQASGLNEIGAYVNYAYGDETPQQWYGSEQWRQDRLRALKKKYDPAGKFSFYGPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXH8</accession>
    <name>B0XXH8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_048380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXH8"/>
    <dbReference type="HOGENOM" id="CLU_009030_2_0_1"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="PhylomeDB" id="B0XXH8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="721" mass="81109" checksum="E118316C6648107F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXT8</accession>
    <name>B0XXT8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial F1F0 ATP synthase subunit Atp14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_038530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038530"/>
    <dbReference type="HOGENOM" id="CLU_122989_0_1_1"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="123" mass="13574" checksum="7219EE071943CD71" modified="2008-04-08" version="1">MSQTLRASRSLLARVSRQQVSSVTRRSFLTSAVRQADPVQELYLRQLQAYKPTPIKPGDAEAHVQKFSAPAAPQSPEEANLANDLKAYESQDVEVEGQAAAGEAAPVEESWFEEEPEEETAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY68</accession>
    <name>B0XY68_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_039830</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039830"/>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="PhylomeDB" id="B0XY68"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <location>
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            <end position="506"/>
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            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
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        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
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        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00008819"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023211"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP52814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="520" mass="57454" checksum="3FD7DB475B72413E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYQ6</accession>
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        <recommendedName>
            <fullName evidence="5">Reticulocyte-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_041730</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_007593_1_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="503"/>
            <end position="566"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
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        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
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        <location>
            <begin position="666"/>
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        </location>
    </feature>
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        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="91315" checksum="1D442AD2323FB0D0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYR0</accession>
    <name>B0XYR0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_041770</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="544"/>
            <end position="563"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="584"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="620"/>
            <end position="641"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <end position="674"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="756"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1177"/>
            <end position="1200"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1212"/>
            <end position="1235"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1255"/>
            <end position="1282"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1294"/>
            <end position="1317"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1323"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1347"/>
            <end position="1365"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1447"/>
            <end position="1466"/>
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    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="146"/>
            <end position="396"/>
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    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="840"/>
            <end position="1082"/>
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        <location>
            <begin position="20"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="796"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="1129"/>
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        <location>
            <begin position="20"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="32"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP53006.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1484" mass="165622" checksum="EACBB2EDC6CC14A9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYV0</accession>
    <name>B0XYV0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_042170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP53046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:early endosome membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="142" mass="16755" checksum="4FD08197D77FD2EC" modified="2008-04-08" version="1">MQAVPESRQQTFEEIYGPPENFLEIEVRNPQTHGTSRNMYTSYEIVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESTRVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVAGHPLLQTGSKVLASFIQDPNWDRNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ21</accession>
    <name>B0XZ21_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_042870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042870"/>
    <dbReference type="HOGENOM" id="CLU_122515_0_0_1"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ21"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP53117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="136" mass="16091" checksum="CCD48452E9DD94B0" modified="2008-04-08" version="1">MFPQRNILRAAQQLRSAPARAAFQRRLNSTDNKLPWMVDNAFNRERAAVKHHAAATSDLWRKLSIYAVIPCLILGSINAYNLWNEHWEHWEHMPPLEERTEYPYQNVRVKNFPFGDGDKTLFWNDQVNYHNKDKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZB7</accession>
    <name>B0XZB7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_043830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043830"/>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="PhylomeDB" id="B0XZB7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="507" mass="54633" checksum="C23DC724DAA92DC3" modified="2008-04-08" version="1">MSLLREAEKCIANQRSHAALNAFITTVQHLGPLREQVRDAELRRESGRSKSEVDGRLIAFKDNICTRDFPTTCASGILAKFTSPFNATVVEQLSEAGAIVAGKTNLDEFGMGSHCLNSWFGPVKNQRQCQEGRILSAGGSSGGSAVSVATDQCYAALGTDTGGSVRLPAAYTGTVGFKPSYGLVSRWGVVAYANSLDTVGILAKNASTARDVFRIVNRHDPRDPTNLSPRSRSRIASHLQQPALLSRMTSSLRIGVPIEYNISELSPSVRRAWALSIAFLREQGHTIHPVSLPTTKLALSAYYVLAPAEASSNLAKYDGIRYGSRCNSPDSGGQPESYLYAKTRGDGFGLEVKRRILLGAFSLSADAINNYFIQAQRVRRLVQHDFNAVFRAEQPISPSRQKGDTELKSKQAEVDVLICPTAPSCPPQLADLVETDSIFSSLNAYTNDVFTVPASLAGLPAASVPVRVNCRDEGSSDADLAGIQIIGQYGDDELVLKVSESLEGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZI3</accession>
    <name>B0XZI3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS drug efflux transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_033970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033970"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B0XZI3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="566" mass="59969" checksum="767B697B3B735A1B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y031</accession>
    <name>B0Y031_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_045440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y031"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045440"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_1"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="PhylomeDB" id="B0Y031"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="227" mass="25134" checksum="357DA7F96C037A98" modified="2008-04-08" version="1">MIMGNRFCTLSGPLEFVREHDAICTTIEYRLAPKHPYPAPIEGCYAGLVWVHEHAEELGIDSTRIVINGLSAGGGLAAGVALLCRDRKGPPLIGQSLFSPMIDDCNDSVSAHEFTGTGIWDRNANMAGWNAYLGDRRGSYNVNVYAAPIRAKNLTGLPPAYIDVGSTETFRDEDVQYAQNMWRDGTQCELHVWPGAYHGFEGLCPRAQLSIMARKARLDWLRRSLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0H4</accession>
    <name>B0Y0H4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_046200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0H4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046200"/>
    <dbReference type="HOGENOM" id="CLU_057752_0_0_1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0H4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="279" mass="31715" checksum="02AE31A314350608" modified="2008-04-08" version="1">MARKGKGKKKTKPKISEISAGSAIASTETAVAKDEVTAKMKELVLRHYLNPKYSDLTIICNGEVFPAHRNIVCPQSMYFENACDGRFKESNGEVILEDRDPILVRKMLEFLYTGDYTFEAPNAKGSFESENTSGEVSHTDLDQDLQVSQGETSSAHPRTDQAFFHAQMYAQGAYFQIEGLKMKAKEYFRESFMRFTDRESYTSAVLEVYGSTEDHDRGLRDLVVQMTTDNLLLLRANNNPILDGTFLEAVPNFMLEICLSALDRCAKHQREYRGWSYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0I3</accession>
    <name>B0Y0I3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_046300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0I3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046300"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0I3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="330" mass="35626" checksum="5FD4CCF7C5C4111C" modified="2008-04-08" version="1">MTARYADVHKNPQGPGDARPTAMQIIHDEGLEGKLADSSILITGASSGIGVETAKALFTTGATLYLTARNLPKAKHALGDMASSPRVHLLELDLESLASVRACAAQLHSKTKTLNIFIANAGVMATPEGRTKDGFETQLGTNYLSHFLLFLLLRPALLAAATPQANSRVVLLSSIAHRYSEVEFDNLNLDGQYDRWKAYGQSKCALVWAANEIDRRYASRGLRAFSVQPGGIMTGLVQHLSEEEQSGFTEDPTLGLQFKSPQQGAATSVWAAVSRSLDGMGGKYLENVQIAEAYDASGGPWAPGYAPYAYSPEKERRLWDVSLKLVGVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0L9</accession>
    <name>B0Y0L9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_057780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057780"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0L9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF311">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="451" mass="50020" checksum="E0DC3B3BFE471D23" modified="2008-04-08" version="1">MSCCAVHEHKVLKNDRHSAQHSRRVRITQSKSMKVIIVGAGIGGLACAIACRRRNLDVLILEQSAEIVPVGAGIQVPPNGARIMQELGLLSRIEEQGMKLEVMDLRRYKDGRIITSMPCGESIVKEYGAPWIVIHRADYHRILLDKARDLGVAIRLGALVEKVLVDDTAVIVGSETIAGDVIIGADGLWSKIREAVLDEPHPPEETGDLAYRATFSRAQLLALNDPEVKALCEKQGVTAWLGPKKHAVFYPVRGGHEYNLVLLQPDDLPPGVRTTQGDVDEMRYGYREWDPTLAKMISCIPAVLKWKLCHLPELPRWTKGSVTLLGDACHPTLPYQAQGAAMAVEDGAVLGLLLHHVASSPDYRSKIPQALKLYEDLRKPRTARNVQGAIRNRRGFHLEDGLLQRLRDLVLSWSGLTRGTDWIGLMSSRQRAVLGFDVLQEVEQRMPELST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0M2</accession>
    <name>B0Y0M2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_057810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057810"/>
    <dbReference type="HOGENOM" id="CLU_080238_1_0_1"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="284" mass="32620" checksum="DEDB0A303AEFCE9C" modified="2008-04-08" version="1">MVMQYWPPKVYPDPTDSSMTHMLPGLTTPLTSSITSTRYGVASYHNHNITMSLLSLLVLSVILTSAYFYVSHRSLASPIHPVIHTGTLPRSVSSSILSIPPSVYTKEYFSLYNLASRSVPRQLLPSPDLPALFVLLLRRNLTVFSHFPKAWKQRSTCSRELSRTFRSSYIQSLDFNEGDIVCKVYRVLVRKPDRVEFEVDMEECDGRWVLRYWEEGEDVVFCSEAVSWRPTEAESPMPGENGLLRFIHETMTWWLLDSGVRYLMDLDADLGPEEEEAEDKERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0P0</accession>
    <name>B0Y0P0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_058000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0P0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058000"/>
    <dbReference type="HOGENOM" id="CLU_2157793_0_0_1"/>
    <dbReference type="OrthoDB" id="4427889at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="111" mass="12616" checksum="939CB2F7675D485C" modified="2008-04-08" version="1">MASLCCHCPSVFSGTVSILRQPKEQQISSSQLRELFCLYSTMAKESSNLLKHYLKLVNELRELKQANDSKEFSLKERVSSFKMKITPSKADEHSGYGLKRVPTPHPLMARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0V7</accession>
    <name>B0Y0V7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_058690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058690"/>
    <dbReference type="HOGENOM" id="CLU_103864_1_0_1"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0V7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="145" mass="15922" checksum="9EF714CC11EF5B3B" modified="2008-04-08" version="1">MSDPLLFDDTFTITAINSQKYDRVSRLSCTSSDSVTTFTLDINSELYPCAVGESVSMALASTLSLDGKEATGAKASWREVGAGEQTLANDYDYVCHGKVYRFEEAATQGNMAVFVSFGGLLLYLEGPYKKLAPLRIDYVYLLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y261</accession>
    <name>B0Y261_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_061390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y261"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061390"/>
    <dbReference type="HOGENOM" id="CLU_2096359_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="116" mass="13025" checksum="8F7A2A5B3839CAC0" modified="2008-04-08" version="1">MAPPPLPIIADDDSTRDDGLLAQVALAQLLVEFQQAQTAQPLGVKDRRVKQVELSLGYRMLQYRWNTSSEGPSTGVFPILSPFSRPYGNLPRCYDPTSRVQHFTGESQQQQCYLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2G4</accession>
    <name>B0Y2G4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_051360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051360"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2G4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000283">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="517" mass="57213" checksum="CAE3BFBEB2ED1311" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2J2</accession>
    <name>B0Y2J2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="1">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_062010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="1"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2J2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062010"/>
    <dbReference type="HOGENOM" id="CLU_002351_7_2_1"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2J2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000208">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF75">
        <property type="entry name" value="SYNTHASE SUBUNIT OF TREHALOSE-6-PHOSPHATE SYNTHASE_PHOSPHATASE COMPLEX (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="476" mass="53096" checksum="65991A2E3A991C9F" modified="2008-04-08" version="1">MASEEQNKRGLIIVSNRLPLSLKKVDGGFESSLSSGGLVTALSGLTNSTTFKWFGWPGINIPDPEEQKKAADALEEKGAKGIFLEEKLGHAHYNGFSNSILWPILHYQSGADFNEDYWKAYQCVNEIFADTVANQAQDGDLIWVHDYHLLLLPALLRERLKSQGKTCRIGFTLHTPFPAGDFWRSLPVEKELLKGVLACDVIGFHTEEYKRNFTEACEQCVGAQATDSNGITFDDHCAHVGVFVVGIDPQKFDDALRDDAVIKRIQELDEQYRDKIVIAGVDRLDYTKGLVQKLQGFEEFLQENPELAKKVVLIQVAVPSREDVKEYQELETEISTLVGKICGTYATPEGVPLIYIHRSVSFPELTALYCVAKACLITPRRDGMNLVASEYVACQENRYGVLVLSELAGAASFLGHGSVTFHPSSTRELANAIHQAVTMDDREKKRRHQELREFVTTHTSAKWGETFVDALAKHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2L2</accession>
    <name>B0Y2L2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_062220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2L2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062220"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2L2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="531" mass="58541" checksum="F2E9FB6943D27128" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2Z3</accession>
    <name>B0Y2Z3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_052380</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2Z3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052380"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2Z3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP51234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="522" mass="56152" checksum="B34325BD44D2D7C2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y328</accession>
    <name>B0Y328_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_052730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y328"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052730"/>
    <dbReference type="HOGENOM" id="CLU_009902_0_1_1"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="PhylomeDB" id="B0Y328"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000067">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase complex core protein 2 (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="13">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="14">
        <location>
            <begin position="198"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP51269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="48075" checksum="59D334351E05F8D0" modified="2008-04-08" version="1">MLSRSSLSRNAPRALSAASASSRRSMASAATPGLQYDVSESAGVKVANREVAGPTGTLALVAKAGSRYQPFPGFSDALEFFAFKSTLKRSALRITREVELLGGEVSSTHSRENVVLKAKFLSKDLPYFAELLAEVAFQTKFAGHELNELVLNLIKYRQQAFAADAENIAVDAAHALAFHRGLGENITPSASGPFEKYLSADAIAEFAKDAYAKSNIAIVGSGSSTAEVSRWVGEFFTEVPSAGGSSQFKVRPNTASKYYGGEQRISSKSGNAVVIAFPGSSTFGTSGYKPEASVLAALLGGESSIKWTPGFSLLAKATQGFSQVRVATKNNAYSDAGLFTITVSGKADQVAAASKNVVDVLKKTAAGEIAGDEIKKAIALAKFRALESAQTLETGLEATGAALINGSKPYQIGEIAQGFDSVTEAQIKDAAKSFLSGKASVAAVGDLFQLPYGEDLGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y370</accession>
    <name>B0Y370_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead transcription factor (Sep1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_053150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y370"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053150"/>
    <dbReference type="HOGENOM" id="CLU_012536_0_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="PhylomeDB" id="B0Y370"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="211"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="211"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="694"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="724" mass="79258" checksum="ADC6DA4BC19FC96D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3E3</accession>
    <name>B0Y3E3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_053900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3E3"/>
    <dbReference type="HOGENOM" id="CLU_023536_1_0_1"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3E3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="580" mass="64798" checksum="9422C4F746887822" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3I8</accession>
    <name>B0Y3I8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_054350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3I8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054350"/>
    <dbReference type="HOGENOM" id="CLU_1061852_0_0_1"/>
    <dbReference type="OrthoDB" id="10264449at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF6">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="289" mass="32811" checksum="1574D92683F70986" modified="2008-04-08" version="1">MMWSPCSRVSLSLSLSLSLSLASMVCFSYLLQALMAITLPAGILSWGLLPFQSSRHQLQPVPQSQTPLDAPGCDGSGIVEPGGRCNGDGLVDSPPDHRDREGFKFENPSTDCKYVSQMHIWDSFKDLEKDMNKLFTLIHKNVSFTVVGHHPIAGHYNDLLHFYVNALRRVSVLFLDHADKFEIHPQAIHGGCNERWSVQEVNFRGVMNSGDDFDIVNVWVTRWDRGQMVEIRTYIDSARIMEALHKNEIWWNGTTFRDNIHYMPGPAGMPDLKKLEDLMGYPDGRKYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4H3</accession>
    <name>B0Y4H3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RWD domain protein (Gir2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_069090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4H3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069090"/>
    <dbReference type="HOGENOM" id="CLU_084528_0_1_1"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4H3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000075">
        <property type="entry name" value="RWD domain-containing protein (Gir2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="236" mass="26984" checksum="1998AC6882E10C68" modified="2008-04-08" version="1">MGREEQVEEREVLDSIFPEEITDISDTAYRISINLETPENDARGEEETEQPALILQVSYPPEYPDVAPDLEISSPPNAPKHPLLDIQEDRERLLEALQPTIEENLGMAMVFTLVSTLKESAELLMAERANAVQAAKEMEAAKAEEEENRKFQGTAVTPETFLEWRERFRKEMEEKEQREREEKEADEKRAKKAPVKEEKKLTGKQLWERGLAGKADYDEDDEDAIPAAVEKIKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4T4</accession>
    <name>B0Y4T4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_070230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070230"/>
    <dbReference type="HOGENOM" id="CLU_047034_1_0_1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4T4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="311" mass="34574" checksum="001F80EC43ACB407" modified="2008-04-08" version="1">MAIIDAVRNGNAGYGDKRQPFGPQTCLPLWTSLCVPPAEYSMIPPPSPPVRSATIHANISLQQANQYHNDFAPDPDYPDSLITIHTSPKVGIGQRAFLCRTAYGNVLWDCLSYIDEDTTRQINELGGLAAIVISHPHFFGANVHWAEVFGCPVYIAAEDEEWVMRKSERQVFWEGRELRIPLPGKGDGDADLVAVKTGGHFPGSSVLWFKPLRKLLVADSIAVVPSGVYHKDRLPGTASYTFMWSYPNMIPLPPDAVLNIWKAIKHTEFDDAHGAFVGWDTHGDSKKRVLESAKIYVRAMGYLDHAIHQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y580</accession>
    <name>B0Y580_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-binding enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_071690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y580"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071690"/>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B0Y580"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="172"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="596" mass="65175" checksum="EB68C4C07EBF0B6A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5L6</accession>
    <name>B0Y5L6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_063820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063820"/>
    <dbReference type="HOGENOM" id="CLU_001872_1_1_1"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5L6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000176">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000212">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="659"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1257"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1367" mass="153004" checksum="D5984484605F428B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5M1</accession>
    <name>B0Y5M1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-3-methyladenine glycosylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_063870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5M1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063870"/>
    <dbReference type="HOGENOM" id="CLU_000445_72_0_1"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5M1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="197"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="382" mass="41827" checksum="11EDD0FDE15D0D16" modified="2008-04-08" version="1">MALRRSARLNTALNNKVLPPQPRSPPKKSSRPQSSNRVNKAKSRSRKDVNDLKISVEQLPLDVTLPDSGAIPVSNNNVETVNTLDLISTDPPSRLHATPPPLDRPVEPHRTNATLLTPHGSSLVAYPPGSESLSPSKTGRPRPTATTGTLLEKAVAHLIATDARLEPLIRRHPCPLFSPEGLAEEIDPFRSLVSSIIGQQVSGAAARSIKDKFVALFNKDNEGQDPAKPPRFPTPEEVVQCDLATLRTAGLSQRKAEYIHGLSQKFATGELSARMLLNASDEELVEKLTAVRGLGRWSVEMFACFALKRIDVFSTGDLGVQRGCAAFMGKDVSKLKAKGGGKFKYMAEKDMLELAAKFAPYRSLFMWYMWRVEDVDVTVMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5M3</accession>
    <name>B0Y5M3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GPI-anchored cell wall organization protein Ecm33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_063890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5M3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063890"/>
    <dbReference type="HOGENOM" id="CLU_035846_0_1_1"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5M3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760451" evidence="5">
        <location>
            <begin position="20"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="398" mass="41471" checksum="618D918DC2BEFEA6" modified="2008-04-08" version="1">MALLKYALPALAAAQAVLAANCGKTDETITISSQSDADGYSSCSTIKGTIEIDEHLSGAITFNNVKQIDGTLSCTGGANISSIAAPMLNSIADTFKLDGLTTLTTLSFPSLTSVGSIQWTALPQLQSLDFTKGVNEAGDVTITNTGLANLNGISLNTVGKFDITENTQLKSININNLKNATGLINFAGNLNSLEVELPNLSSGTNMTFRNVSAVSVPSLHNLTGQLGFWGDTFKSFSAPNLTETGDLVFNSNSKLTNISMPALETVNGGFLITRNDELSSIDLPSLKVVTGAVDFSGKFDEVSMPKLENVKGQFNLQSTGNFSCDTFDKAHNDKVIRGTYKCKAAEPNPTTKDGSSGTTTSSGSSASASKSNAADLNAANLPALGFAAVFGALVQYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6B2</accession>
    <name>B0Y6B2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_066300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6B2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066300"/>
    <dbReference type="HOGENOM" id="CLU_081029_0_0_1"/>
    <dbReference type="OrthoDB" id="4160190at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="261" mass="29249" checksum="7618F368D8119994" modified="2008-04-08" version="1">MSHHTVSVFDHDWPLPPLLPSRRESAFSTSTVHGTKLPVPHLEHPKLRDEPSLRISFLEEQTVQSACTVFTTKLSYTFEDWQDCVQFQELILAAKLVFIAGIAEAKSKGRGEECISQNLRIFRGYNGKQVMLFFANSQRKELKRYVSIPGMGPLQSSLAALYPIYATILTLCEVNCIETVNPGKKAGRPVVLDLQPNFDLLSQMKTLHIQFLDDQDTVSEQRISGTLLLGSTTRNRHRHRHGDSGLPIQGIAKAVHAVIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6I9</accession>
    <name>B0Y6I9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_067120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6I9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067120"/>
    <dbReference type="HOGENOM" id="CLU_033261_0_0_1"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6I9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="195"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="379"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="487" mass="54519" checksum="46E50F94F848D9B7" modified="2008-04-08" version="1">MVLDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQAQIHQQRHQRRMEIETLKYERIINDGLLSRIDKLLALLREHEGSSRDPEELVFQAVMESASNPAEDQAPVPPEGVHTHEKEQPKYSQMLSSLVDQVKKEIGESSPDNRYQAYIKGVEGHQDKVQGLQKELLARLAQLEKEESSKITSDMLHTGFDTSYISKSKDKGKAPATAKSETVELLNPRAVQDDAPKADDNEQVDPDDVKASDLAKKFARINRNDYRALLQFISEHPEIVAEKETDGLLVEAFNSQMEGKEEYARQCVHQGLLLQYCRSLGRDGISLFFKRITTKDHQAATLFRNDVNETYNKIKTRAAELAKDSSAANDPAGVEQIQLHAVDPNTKITINIPPADSNDPAVIEARKIFESFSEDMQKALASESLDEVNKVLGKMPVNEAEEVVEKLGAGGLLSLEEGIVDATTEEGRKKLEEIEAEGRKEKHVEEIGEPGGDVTELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Y2</accession>
    <name>B0Y6Y2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_068540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6Y2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068540"/>
    <dbReference type="HOGENOM" id="CLU_054588_0_0_1"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6Y2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40295" checksum="5866D595B0F14AFD" modified="2008-04-08" version="1">MSTKLIFLMGAPTPQSLCWDEDGLLDNPIFPFSGPNGEDQLNQPVSETHAVKWRLLQDLKVQEQERASVCSEPGRHAIFLNTQDLTPLDGVSSISPDDSSIPEFYDHSFAVHETSEISLPGAHLGDSMQESGLATDSTGTSVVSSSDREAPEVGSLAIQGGLNDLRDIPSATYLQSIGPQTMTVNLIVGIIAIHPPRRIVTRQWKRELDLVEMVVGDETRTGFGVTFWLPLGDETNATGRCDLETEKLRTSLSSLRPRDIVLLRMVGLSSFRERVYGQSVGRGATKVDLLHRQRIDATDAGGIYSTRRLQTFRDDETKPGDLPLLMKVCKVREWIRLFVDRAPDLVGGGPRTSTKHGQPLPPDTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Z5</accession>
    <name>B0Y6Z5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_068670</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6Z5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068670"/>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_1"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6Z5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="681"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP50530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118928" checksum="9861BC7A7873EF8E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y767</accession>
    <name>B0Y767_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_072740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y767"/>
    <dbReference type="HOGENOM" id="CLU_020684_0_0_1"/>
    <dbReference type="OrthoDB" id="3882058at2759"/>
    <dbReference type="PhylomeDB" id="B0Y767"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="56868" checksum="C663939BE8491946" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7C2</accession>
    <name>B0Y7C2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_073300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7C2"/>
    <dbReference type="MEROPS" id="M24.017"/>
    <dbReference type="HOGENOM" id="CLU_015857_2_1_1"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7C2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP49303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="422" mass="46916" checksum="64668801978C5D52" modified="2008-04-08" version="1">MGVEVATRKCMGVECANNAGSLQCPTCLKMGTDSFFCSQDCFKRSWSEHKAIHKSKSNILSNLFPPKVVSEPDPATGHFNPFPSFQFTGSLRPVYPLSPMRTVPKSIPHPDYAKDGIPRSEQKFVGRHNITILNKEQQEGMRKVCRLAREVLDIAAREVRPGVTTDYIDEVVHKACLERNVSGCLFVRKEQRKRSQSNMSQSYPSPLNYMHFPKSVCTSVNETICHGIPDQRPLEDGDIINIDVTLYHNGFHGDLNETYYVGDKARANPDAVRVVETSRECLEKAIELVKPGMLFREPGNVIEKLAKSRNCSVVKSYCGHGINQLFHCAPNVPHYAKNKAVGTAKPGMCFTIEPMINIGTHRDRTWPDDWTSTTADGSLSAQFEHTLLVTEDGVEVLTARLPDSPGGPIPMPVTEDAKTAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7F7</accession>
    <name>B0Y7F7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_073650</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3"/>
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        <property type="protein sequence ID" value="EDP49338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073650"/>
    <dbReference type="HOGENOM" id="CLU_020346_3_0_1"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="mRNA cap guanine-N7 methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="16">
        <location>
            <begin position="310"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP49338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="668" mass="74929" checksum="AF2AEA274B0F624B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7L3</accession>
    <name>B0Y7L3_ASPFC</name>
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        <submittedName>
            <fullName evidence="3">CwfJ domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AFUB_074210</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="353"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="1">
        <location>
            <begin position="551"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="607" mass="67233" checksum="A8AB582447A47EFC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7U9</accession>
    <name>B0Y7U9_ASPFC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AFUB_075090</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <lineage>
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            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7U9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075090"/>
    <dbReference type="HOGENOM" id="CLU_1562531_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="171" mass="16642" checksum="2FE4DE151F6C0001" modified="2008-04-08" version="1">MPGVPPDALQQLKKGLKAIFSRKKKKAQNNQNEPAPAADKPVEQAATAPAAGAGAAAAAAAVPATEAKPAEPAPATEPKPEQAAVADKSAEAATQSTETQPGSSTTTAPEAKTEAPAPEPTAAAPAVPETTTSATAPAETAPAAPAPAAEPTPAQPTAEKPAETAEPPKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8H4</accession>
    <name>B0Y8H4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_077350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8H4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077350"/>
    <dbReference type="HOGENOM" id="CLU_020880_3_0_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8H4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000053">
        <property type="entry name" value="Histidine acid phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF23">
        <property type="entry name" value="3-PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758742" description="3-phytase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="51"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="408"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="471" mass="52044" checksum="E47567FCB0D1EF0F" modified="2008-04-08" version="1">MRRTLQALWLLSLGYAPSVHALEPLEHLGANSPWFAGPNVNKISSDVPGLCSVDQAIYVVRHGSRYPDPGAYAQWQALYDSFQSAKFKASGSLSFISEWAPVLRYPDQQIAQVSLTGYKELYNLGVDLRFRYPSFYEDNTPFVLWANDYKRTIDSARLFARGYLGSNSTYGDIYVVNPDVAAATGNSLATSDMCPNFKDTSGGTYASTWDKIYLPPITKRLNKKISGNLTLTDDQVSIFPYLCGFETQITGSRSPWCDVFTPNEILQYEYRQDLRYYYGTGPGAGKNMTVMLPVLQGIVNLLEDGPSATANTTTGMSKLPPLIVAFTHDNQINELASLIGVFDEQEPLAADKMDKKRIYVSTRVNPMRGTIAFERLNCTSRGKNSVNVRIRLNDAVYLRLTSIAVPSCRSGPGHSCPLDQYTALVAKKREQYGSFASVCGLPEGNVTTATLDGAVTFFNDLTLPFLSVVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8M0</accession>
    <name>B0Y8M0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_077830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8M0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077830"/>
    <dbReference type="HOGENOM" id="CLU_020161_4_0_1"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8M0"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF88">
        <property type="entry name" value="BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758285" description="endo-1,4-beta-xylanase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="31"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP49751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="308" mass="34141" checksum="293D8DC4CD4AD159" modified="2008-04-08" version="1">MSHSRTMGAFCAATLITAFLAAAEGTNAFTNTGTSPLRKEAASKGILIGSGAINQTYLDNPQFATILAEQFQSLSPENEMKWPFIHPTPGHYNWDTIDRLVGFAENNDMVVKGHGLISSCCNPDYLLNITNPKLFRAAMVDHFRRSCTDTLASGLQTNGFYNVLGPDYIGEAFRIARTVCPGAKLFINENLVESRPGKRQELYDLVSRLVAKDIPIDVHSYKALVLEVSIAEMDVHTLNTTLHTDIYSAVITEALDARITDISFWGFTDKYAYTWLEGAKPLMFDEYYNPKGAFYATHTALTSLDNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8R4</accession>
    <name>B0Y8R4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_078270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8R4"/>
    <dbReference type="HOGENOM" id="CLU_003155_0_0_1"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8R4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02666">
        <property type="entry name" value="Peptidase_C19J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000122">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="560"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="686"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1204" mass="135242" checksum="88067CBA7652CEB5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8R9</accession>
    <name>B0Y8R9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_078320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078320"/>
    <dbReference type="HOGENOM" id="CLU_047842_0_0_1"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8R9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="246"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="484" mass="53911" checksum="69B091831CA2D11A" modified="2008-04-08" version="1">MPLRISRTCLAQAAINSPVPFLYQTRTLAAPLSYAKWSARDGRSFQSTSTTFTTPESSLHRGEESAHDGESSENATPPLESDSPSPAPSNDGRRSRRSYLKKRGAAVSQSRTPPSSQPPRRPLTMTESEKRAFGGLLEQMGVKEKEDLEAATEATDKPALSKDEMHKISNIFNSVLEDLRKKKEGSEVSTEGAGKRKSRRQVDEPASTSKPGPQEQAVDSNPPESRSDVPRSAELAIQFTVQRESAKIERALRAAIDEGKGDTGIWEVCKERVFSMLRYLGESRVPEDSGALPTSSEGEPTPHSPLEVPESVSVEAVVTELYPKMLLLAFRLLNSHFPGSPLIGQFRSTIRSHGRTSAVLGSSTGLYNELIYFYWRGCSDLPSVVSLLKEMETTGVEPDERTCGLLKAIAEQRERDLKNHRKRVRRENQDRSSPRDPWWDMAPNRTAVKELFGEDGWLPRLEKRVKEIRNLQSSTRLLADRLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y931</accession>
    <name>B0Y931_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_079450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y931"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079450"/>
    <dbReference type="HOGENOM" id="CLU_013866_5_1_1"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="PhylomeDB" id="B0Y931"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP49912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="499" mass="56697" checksum="DF6CE6B12B527F9E" modified="2008-04-08" version="1">MVFRGRPSKACERCRSRRLKCDYRPDSCTPCLRAAAVCYGYRDPQAIRIEDQTEDARRKALLKSKPARLAEASLSVSIDARARMVFFAHYVSVGSRGWDFLIRWERETEVAPRWLNVSIDAVSLALLAHHHASAPLLSLARQRYALALRVMKQALNFAPTEIDSLIAASLLLDLFEKITHTEASVIQFWPSHVNGTLALIRKIGVGHFQDHYALRIMARFLTNYIISCVASAHALSKDVLILRDHLERHLDLKDDPKWKISGLTIEYASFLHAVHTGRWSLQDRMARAQDLDRALLAVSQDMPPDWQPERRILQYPLPHVYGQEMDLYRDRHVTQTWNVVRQVRIQLNEYLLDCYETLNAVHGVNQLAASEAALSDIAALSLEVYASVPQYASYACRSKRSQGQADNTDLSVVSQKGCNKVHTPSELLDCYTLLFPMYVAARSKAATADQRRWVSYMFRYISDHFGIRNALLLAQLLDQNSDISPWCIYAMLGGYGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y948</accession>
    <name>B0Y948_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_079630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y948"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079630"/>
    <dbReference type="HOGENOM" id="CLU_1959095_0_0_1"/>
    <dbReference type="OrthoDB" id="20229at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="135" mass="15519" checksum="9F8F9E2A7EDDD315" modified="2008-04-08" version="1">MRTQGVRIILSEYHAILHRDKYAILYFCDSCDHCASLDPTYNDMASAVADADDMIDFYKINMSRHRDISDTAMVEKPTLLLVKDGRELERFCKPVPQQLEYMVSQALCGMTKISMIPYTEREGHGDLMYCIPAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y983</accession>
    <name>B0Y983_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_080110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y983"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080110"/>
    <dbReference type="HOGENOM" id="CLU_452119_0_0_1"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="PhylomeDB" id="B0Y983"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="620" mass="69063" checksum="DE2F5F50D19836EF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9P7</accession>
    <name>B0Y9P7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_081820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081820"/>
    <dbReference type="HOGENOM" id="CLU_780688_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0Y9P7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="355" mass="39062" checksum="5C272B85F6B4961C" modified="2008-04-08" version="1">MYLIPKALFIATVLGARTNHHNNPVESGKMLASLTEKASIVTGTVGFGELCLYDGPQGLHFADLRSVFPSELAAAAPWDRCYLDGDGERWEPSFVAKSLSRFPWAQPIGFGGGGKGNWEGFFPDPSLRRCHAGVYSQRAGCWYAGLCQTLYLATNNKPISQADVFLRKFSLLKKNMRDELDFQGYVMSDFFATHSGLFAINAGLDLNMPGYLSEAAFNHSYFQCGFLVFVMELFLNGAGRDVRGNHSLLIRKIGSAGTVLLKNKDKTLPIRPAWVIGVFGNDAPDINGDPSPGWNCWQSLEADWNLILVVNNVASICRRTVIITHSDGIMRTSLLFSQRITLGKSLEIPSPTTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9S9</accession>
    <name>B0Y9S9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SHE3</name>
        <name evidence="11" type="ORF">AFUB_082140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SHE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9S9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082140"/>
    <dbReference type="HOGENOM" id="CLU_050241_0_0_1"/>
    <dbReference type="OrthoDB" id="3918393at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9S9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031398">
        <property type="entry name" value="She3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17078">
        <property type="entry name" value="SHE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="112"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP48772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="348" mass="40039" checksum="1F04F1E5BF7FD1B7" modified="2008-04-08" version="1">MARLVRSKKNAARAESDNADPETLASPTLDSPRPPRVSLPHVETRLNMHQYNGLFDVNSPECQKATIAVETSPDSTSLSARTTSNPPNGDAATAEWSSAVGHATTGKSGRVIHNLQEEIARLTRECSVYRSRAEETQRMNDAFKMQVQNMTERLRNLEHANETNLQSIRRKDKKIEELRAEVQSEKERRRRAEGETDKFQQLMNEARDEFNRKCAELQEIANHSRTQYDVLAKAGQRERADQQRKLKAIRDDFLALKAEHEKRDVHLERLDTVISQKNREIEIGRERFDQLFEDYEAYKKAHDEEVRALIERNYQGAANIDSALASLKETEEKMKWAIQVKNEIKDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Z2</accession>
    <name>B0Y9Z2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_082780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9Z2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082780"/>
    <dbReference type="HOGENOM" id="CLU_008615_0_1_1"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9Z2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="490"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="728" mass="80026" checksum="B2A5E8A656057810" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA13</accession>
    <name>B0YA13_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_083000</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083000"/>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="PhylomeDB" id="B0YA13"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097586">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="329"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="399"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP48856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="780" mass="88809" checksum="3923015030913F1A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAG8</accession>
    <name>B0YAG8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_084620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084620"/>
    <dbReference type="HOGENOM" id="CLU_005767_3_1_1"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="PhylomeDB" id="B0YAG8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="805" mass="89540" checksum="DCE0430BBC4417A7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAL4</accession>
    <name>B0YAL4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_085070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085070"/>
    <dbReference type="HOGENOM" id="CLU_068498_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="385" mass="43420" checksum="A1A397E500A38BD0" modified="2008-04-08" version="1">MDGSRYQLVDSLYGPGTVGAWLLSLCAVLISWTLNTSSRRKDTISVDFITTLLLPFIAAGHAIFQITRLPAPVAEVITAQQVELQRYASALEAPLNICETFSVAALLLAVFCGPWWGSDPKWTRLGLVLIVGLLSWGTENIMFGLGTLKGVRAPEMTLTRPYLFFFTPIVASTWAFLALCLAVGAIVWIVSIGNNQATRRGLERRHLQRAPSRVFDESRPYKPSRITQETRDYALHELQALEPMSRSIQMVTFVSILFLPFSLIASTFGFMSVDMKSLSSTSQNQFILIPNSNGSLSHLDQLLALVGDVKWDMFQNFLSRDDVPYDKRKFQVDKQQPWLSTTLPWLGCERGIHVAMWDGSARRQRGASRVRGFKWRRYSYQMCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAM7</accession>
    <name>B0YAM7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endochitinase B1</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chitinase B1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_085200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a role in the morphogenesis and autolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAM7"/>
    <dbReference type="SMR" id="B0YAM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085200"/>
    <dbReference type="HOGENOM" id="CLU_002833_1_0_1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="PhylomeDB" id="B0YAM7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760812" description="Endochitinase B1" evidence="14">
        <location>
            <begin position="23"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="43"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP49070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="433" mass="47622" checksum="95AECA3DCE917D30" modified="2008-04-08" version="1">MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC25</accession>
    <name>B0YC25_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1711 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_088660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC25"/>
    <dbReference type="HOGENOM" id="CLU_058488_1_0_1"/>
    <dbReference type="OrthoDB" id="4093188at2759"/>
    <dbReference type="PhylomeDB" id="B0YC25"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="27191" checksum="DCD729A0BE904F4E" modified="2008-04-08" version="1">MAAATSTTNGRSNRSAAPKAIVILRLSPELLSRFASPDVKEKATKKNSTSASPPVKEKEPSSPASSSADLPVPPSSVDNASDAASTPAPGTSAADTPRRNGLPAPKSGTKRSAGQATESFSRPRGKPGPKKKPRLDDGTADSVKVTSSRLGPKANMGAINAGLRALDRSGTPCRKWERKALQLKSFTGVQWQLPSWRAPRPQKIETNDEVKEATLDTGDSDSKANQSASGAPSEKSNSGDTELTPVPPNITEASSPAIAMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC78</accession>
    <name>B0YC78_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein PXR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PinX1-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein pxr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_089220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC78"/>
    <dbReference type="SMR" id="B0YC78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089220"/>
    <dbReference type="HOGENOM" id="CLU_052839_0_0_1"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="PhylomeDB" id="B0YC78"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="11">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP48209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="304" mass="34011" checksum="030A8A315452999B" modified="2008-04-08" version="1">MGLAAPRKKTKISHDPNNTSWSRSTDGFGHRILKAQGWTPGDFLGARNATHSDLFTTASASHIRVVLKDDTLGLGARPKRDLLDGPTGLDAFKGLLGRLNGKSDTQLEAEQQKRDDAKLARYAATKWQTVRFISGGLLVQEKDNATASPASQDLRVDFPRETSSNEHENGMFKTEPMDSYSHQEGCATAREEEGKKKKKKNKKGKEMDMSPRKSREKKQEKIQKKRKIGDCDRLDTETADRTSTKVLVAVANDKGTSLLASNGPSTSRERQPMGRRIFRSRHIEQKKRALMDDKSLNEIFMIKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCZ3</accession>
    <name>RRP36_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>rRNA biogenesis protein rrp36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ribosomal RNA-processing protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rrp36</name>
        <name type="ORF">AFUB_093710</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCZ3"/>
    <dbReference type="SMR" id="B0YCZ3"/>
    <dbReference type="EnsemblFungi" id="EDP47527">
        <property type="protein sequence ID" value="EDP47527"/>
        <property type="gene ID" value="AFUB_093710"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093710"/>
    <dbReference type="HOGENOM" id="CLU_048802_0_0_1"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="PhylomeDB" id="B0YCZ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000397617" description="rRNA biogenesis protein rrp36">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="356" mass="40206" checksum="AC317648A438A233" modified="2008-04-08" version="1">MAVSDLLNRRVRALPDEDEELYSEASVSELESNDEEVEGSGSDISDDSSEGDYSSDSQDESDAMSHENEEEDDEDDENSDDGQDDVQASLSNISFGALAKAQASLGPTAKRKSKATQSKTDDGETPAASPLDDIRARIREAREQKREGSSKSKDLEKFSRSSKHAPMVQSSKHPVTRKRTIIEPPAALKSRDPRFDPAVRSQSGRSEASQSAYAFLDDYRAAELKEMKEKLAKTKDPRQKEALKRDIRSATDRLRTIENRRREKEVLAEHKKREKELIREGKKSTPYFLKKSELKKQALLKKYESMGSRQRVKALERRQKKLTAKERKEMPMERRGLGNDPTPYNDGGGGKRRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDC4</accession>
    <name>B0YDC4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Crh-like protein</fullName>
            <ecNumber evidence="18">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">AFUB_095070</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="18"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095070"/>
    <dbReference type="HOGENOM" id="CLU_027506_3_2_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="PhylomeDB" id="B0YDC4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760624" description="Crh-like protein" evidence="21">
        <location>
            <begin position="18"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="22">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="19">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EDP47658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="357" mass="37704" checksum="788AD261455823FB" modified="2008-04-08" version="1">MMLPLLAVSAFASLGAAQTYTSCNPTNSLKTWSLSTDFTQGSSDGWTAISGNVTYGSNGAEFTINKRYDAPTLETNFYIFFGEVEVVMRAANGTGIVSSIVMESDDLDEIDWECTGTDTTQIQTNYFGKGNTTTYDRAIWETVSSPQDEFHTYKVVWTAAAITWYIDGTAVRTLEYADAVDGKNYPQTPMVVKLGIWAGGDPSNSEGTIEWAGGETDYDEVPFTMYVKSVNIINYNPAASYNYTDKTGSYTSIVASNSTTGSGIHSSNSVSVFAPSSSTSTFTSSRALIATASTYPASVQTSSSGVVSLSSSSASSSSAAASSTSGSASAVFTGAAVTNLPSFFFTVFFALAIALAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDL4</accession>
    <name>B0YDL4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096000"/>
    <dbReference type="HOGENOM" id="CLU_036742_0_1_1"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="PhylomeDB" id="B0YDL4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="476" mass="53899" checksum="285986E59BF6FC26" modified="2008-04-08" version="1">MPRRSSRAVPAPAAAPAPIPKRRASDRTFAASETDLKRQKHNSTTAKKVVRSTARKSKYFEDEGNEESDPESSHASEVGEDSDPAYEDKNLSYPSTESDSEEPEVLSTGEERTKRSTRKTANPSGGRKIPARRGGGNEAEEHPNEDIAASLKDKELWREGVSTGLGPGKEVFIRKPKARDPGDIPYQDHTLHPNTMLFLQDLAKHNDRQWLKAHDADYRASKKDWETFVESLTEKIAEVDNTIPELPAKDIVFRIHRDIRFSKDPTPYKKRPLCRLLCASAARILLCSGLWQPEADKLALLREDIDHNSHRLKAVLQRPDMRREFFNGIPDDEKKAVQAFVSQNKESALKTKPKSFLRRLICFHGSASDYWRGYEADNENIELLRLRSFTIGKPLSDSEFMASNVQERITALIGVMEPFVSHASHPCCAASLGFLPPVHVSTYWILPSRIRYMALPCLVHVTLFLMRFPAIQWYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE05</accession>
    <name>B0YE05_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FluG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_097400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097400"/>
    <dbReference type="HOGENOM" id="CLU_019568_0_0_1"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="PhylomeDB" id="B0YE05"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="73291" checksum="CE5C89A0C3170892" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEL2</accession>
    <name>B0YEL2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_099570</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EDP47356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099570"/>
    <dbReference type="HOGENOM" id="CLU_3124691_0_0_1"/>
    <dbReference type="OrthoDB" id="4447675at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="50" mass="6059" checksum="1B8833C758BEF248" modified="2008-04-08" version="1">MDLLQKHGHLKHDRRKSSARKEEAELRHQQTQQRMRRSTGESLEKRELHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEZ1</accession>
    <name>B0YEZ1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_100990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100990"/>
    <dbReference type="HOGENOM" id="CLU_1133354_0_0_1"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="PhylomeDB" id="B0YEZ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="263" mass="29470" checksum="A8870A5C56434839" modified="2008-04-08" version="1">MASFNPNIPVRGNPFLDIPSDIDAHPFRLVWEDICSVSYLARLLPKGVILDLVECLIQRDLEYKTADIRQGRAQLRAALTASTTKKAVLIVHSQGGIVASSIIDWLYGELSQSQIQKLEIYTFGNAARQFRNPPLHELHHNDPAGTTPRRQIQGERAIRNIEHYANTKDFVANIGALQFTASAGAYSNASVFSGTVFIREGSGHLFNMHYLHPMFGEHSAFMESTVDVRPRNGPGKTVSMRMRELSRLYNYKNGRSPEDQDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF96</accession>
    <name>B0YF96_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_102020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_102020"/>
    <dbReference type="HOGENOM" id="CLU_2941305_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="60" mass="6249" checksum="018DCC5B6BE1BC15" modified="2008-04-08" version="1">MAGLCESDGRGQPSKTRSDKKDIQAHVARGLGDIGQGALQRLRKLEAITGVANTLTVSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XLY8</accession>
    <name>B0XLY8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exo-beta-1,3-glucanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_001500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XLY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001500"/>
    <dbReference type="HOGENOM" id="CLU_002540_2_2_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="PhylomeDB" id="B0XLY8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758162" evidence="5">
        <location>
            <begin position="19"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="441"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="804" mass="84184" checksum="51AE152EC318D6AF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM71</accession>
    <name>B0XM71_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_001150</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001150"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="PhylomeDB" id="B0XM71"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF4">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP55423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="39774" checksum="C1BFA37ABAF35FD1" modified="2008-04-08" version="1">MVTTYNILVLPGDGIGPEVMTEAVKVLKVFENEHRKFNLRQELIGGCSIDAHGKSVTEEVKKAALESDAVLFAAVGGPKWDHIRRGLDGPEGGLLQLRKAMDIYANLRPCSASSPSASIAKEFSPFRQEVIEGVDFVVVRENCGGAYFGKKIEEEDYAMDEWGYSEREIQRITRLSAEIALRHNPPWPVISLDKANVLASSRLWRRVVEKTMTTEYPQVKLVHQLADSASLILATNPRALNGVILADNTFGDMISDQAGSIVGTLGVLPSASLDGLPSETRKRTNGLYEPTHGSAPTIAGQNIANPVAMILCVALMFRYSLDMETEAQRIEKAVQGVLDAGIRTPDLGGKSGTNEVGDAIVAALQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN42</accession>
    <name>B0XN42_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="9">ALO</shortName>
            <ecNumber evidence="4 9">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_014510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="4 9"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014510"/>
    <dbReference type="HOGENOM" id="CLU_003896_4_1_1"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="PhylomeDB" id="B0XN42"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="49"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="595" mass="67456" checksum="7A81BB2097590B45" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNC2</accession>
    <name>B0XNC2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GARP complex subunit (Sac2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_004440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004440"/>
    <dbReference type="HOGENOM" id="CLU_010797_1_0_1"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="PhylomeDB" id="B0XNC2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="163"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="351"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="678" mass="74988" checksum="B5F76498A5F57A4E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNX8</accession>
    <name>B0XNX8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_016040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016040"/>
    <dbReference type="HOGENOM" id="CLU_016743_1_0_1"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="PhylomeDB" id="B0XNX8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="10">
        <location>
            <begin position="460"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="586" mass="63393" checksum="80BC900AB6D92FCD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPB8</accession>
    <name>BGLM_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-glucosidase M</fullName>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-D-glucoside glucohydrolase M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiase M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Gentiobiase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bglM</name>
        <name type="ORF">AFUB_016780</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPB8"/>
    <dbReference type="SMR" id="B0XPB8"/>
    <dbReference type="GlyCosmos" id="B0XPB8">
        <property type="glycosylation" value="10 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP56956">
        <property type="protein sequence ID" value="EDP56956"/>
        <property type="gene ID" value="AFUB_016780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016780"/>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="PhylomeDB" id="B0XPB8"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000008">
        <property type="entry name" value="Beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394904" description="Probable beta-glucosidase M">
        <location>
            <begin position="23"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="769" mass="82625" checksum="861DADD924B2CDE0" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-05-18" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPE1</accession>
    <name>BGLA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-glucosidase A</fullName>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-D-glucoside glucohydrolase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Gentiobiase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bglA</name>
        <name type="synonym">bgl1</name>
        <name type="ORF">AFUB_006160</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPE1"/>
    <dbReference type="SMR" id="B0XPE1"/>
    <dbReference type="Allergome" id="8995">
        <property type="allergen name" value="Asp f Glucosidase"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="B0XPE1">
        <property type="glycosylation" value="12 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP55914">
        <property type="protein sequence ID" value="EDP55914"/>
        <property type="gene ID" value="AFUB_006160"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="PhylomeDB" id="B0XPE1"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001391">
        <property type="entry name" value="Beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394093" description="Probable beta-glucosidase A">
        <location>
            <begin position="20"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="731"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="873" mass="94754" checksum="F94200468834535F" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ56</accession>
    <name>B0XQ56_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_008760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008760"/>
    <dbReference type="HOGENOM" id="CLU_1686140_0_0_1"/>
    <dbReference type="OrthoDB" id="4369670at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="156" mass="17756" checksum="DFC98AB8AA130203" modified="2008-04-08" version="1">MTSDNLDPNIRSWLKAKGLRNHEDIVRLESSAELLTVVLVMLTQILPRRIHGDTGKKSIMLPSINRRRGISDKDQLAIVRNLWKEIPTRSSPQDNSLQAYNVMDLMDDETLEAQHDLERESLSGAMITGDETTHNYFSRNSLALQSNLAEISMLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ94</accession>
    <name>B0XQ94_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_009170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009170"/>
    <dbReference type="HOGENOM" id="CLU_088665_0_0_1"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ94"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="165"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="256" mass="28820" checksum="9C1A572318F363F9" modified="2008-04-08" version="1">MDPALNSDTPPPPPPRPSSHETSRRGTPQLNQSIPGTPQHQFRGYHQAQEGENGENRYQSPLMAAEAFHANNINSLPKPPTVEEGWLPDVVKDKSTVDLQAILRDPNLISALASQHPACTAQQENLQSLLKYNQDLTKHLLELQARLDEQRASTETLLLKHQSLEVSWRKKQSEMDAALAPWSPKALYQRLSASISEQEAVCRAVEESFLEKEHHGRATEKEVADWVRRVRAEAAKLAARREAKARWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQE6</accession>
    <name>B0XQE6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase (AKR8), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_009680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009680"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="PhylomeDB" id="B0XQE6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="321" mass="34992" checksum="865547FC12AC5774" modified="2008-04-08" version="1">MPSLVGKEVGPTGYGMMRMTWAPQLPSEEKCFETLNTALALGANFWNGGELYGTPEYNSLHLLNKYFTKYPENADKVVLSIKGGLKPGELVPDGSEENICRSVDECLRVLDGKKTIDIFECARQDPNTTVEQTVTILAQLVKEGKIKGIGLSEVNAETIRRAHKVHPIAAVEIELSLWDTHTLNDGVAETCAELGIPLVAYSPLGRGVLAGAFTSVSEIPEGDFRKSLPKYQEDAMKHNIKLVNEVKDLASRKGVAPAQIALAWILTLSGKPGMPTIIPIPGGTTSDKVTQNLHGVPRLSDTEMGELDWILKKNEVRGARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQG7</accession>
    <name>B0XQG7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_009900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009900"/>
    <dbReference type="HOGENOM" id="CLU_005936_0_0_1"/>
    <dbReference type="OrthoDB" id="5417895at2759"/>
    <dbReference type="PhylomeDB" id="B0XQG7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="81996" checksum="78491477C873BC45" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQX0</accession>
    <name>B0XQX0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear and cytoplasmic polyadenylated RNA-binding protein pub1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_011450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQX0"/>
    <dbReference type="HOGENOM" id="CLU_025000_1_2_1"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="PhylomeDB" id="B0XQX0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="91"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="181"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="307"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="489" mass="54051" checksum="CD9A351DF4D5F3C1" modified="2008-04-08" version="1">MAENMSTSGSSTLPPPPPQASSASGQQYDSSQGNGQANPSHMPPPPRPPVVIPQNTNPIPTAITSPMSGNMMSPTSAGGYVRRAAPEPNKRALYVGGLDPRVTEDILKQIFETTGHVQSVKIIPDKNDTITALLNLMTLVRLRGLCKPSTAVESISRYAEIRVNWAYQSNSANKEDTSSHFHIFVGDLSNEVNDEILLQAFSAFGSVSEARVMWDMKTGRSRGYGFVAFRERADAEKALNAMDGEWLGSRAIRCNWANQKGQPSISQQQAMAAMGMTPTTPFGHHHFPTHGVQSYDMVVQQTPQWQTTCYVGNLTPYTTQNDLVPLFHNFGYVLETRLQADRGFAFIKMDTHENAAMAICQLNGYNVNGRPLKCSWGKDRPPTGQFDNFSGQQPNSPFNSNPATYFPQYGGPGAPITPQGTFHILSPSNSPHSCWARLGARGNDWPRIWPSPPECRLWPRTGYTQLWLEPAKQWQLWKWLWGLPSVACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR87</accession>
    <name>B0XR87_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2 family helicase/ATPase PasG, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_012490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012490"/>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="PhylomeDB" id="B0XR87"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="213"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="629"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP56538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="867" mass="98039" checksum="75EABC4E82C2DBB2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRI2</accession>
    <name>B0XRI2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_002560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002560"/>
    <dbReference type="HOGENOM" id="CLU_009138_0_0_1"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132352" checksum="8B4941946AEA7D9D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRI3</accession>
    <name>B0XRI3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras GTPase Rab11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_002570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002570"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="B0XRI3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="204" mass="22466" checksum="F6ACF2C4BE8E3FB9" modified="2008-04-08" version="1">MTVLTVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDSKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHQTYDNVNRWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEAKQFASENNLSFIETSALDASNVELAFQNILTEIYRIVSSKALDNGDSGQAPLSSGRTIEVSKAPDTESKQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRN5</accession>
    <name>B0XRN5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_013300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013300"/>
    <dbReference type="HOGENOM" id="CLU_1170427_0_0_1"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26696" checksum="21A77DF8230CFA4B" modified="2008-04-08" version="1">MEEAHAQVFFRQKSIERNATFRIPEVYHAFIVSEGGCTGRGCTYIVMEHIEIDFERTVSDEQRAQAISELISIPPPPGVFGSLSGGRYRHHFFRDSQPPVPFSSATELEYNINRCLAWYNSVAGTQDKVDFSNEPLLCYYADMHPSNFPIDKHGQLWVIDFDQTGVLPSSFMSYAIAAHPKKRLPVHIRKTIPLPKTSNLGPLGRATYLIKVVCNAFDPPPLPNNRTEADAESPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRV2</accession>
    <name>B0XRV2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_024940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024940"/>
    <dbReference type="HOGENOM" id="CLU_1777018_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="146" mass="16262" checksum="7E78EFE65165DF18" modified="2008-04-08" version="1">MTRELPLRLSVALKHEASPVTVHLPPLESDYWSGADENGLTAREKRLPCPWLGGPYGEKKLEKTCCVGPNIRNLLYSSTQTHGNDVTPHNKDSQSNVIARKENNESLPSLEATEPDQFRKCNKCNRCNKGKNNQSTLKNASGIYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS50</accession>
    <name>B0XS50_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adhesin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_025940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025940"/>
    <dbReference type="HOGENOM" id="CLU_161487_0_0_1"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758286" evidence="1">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="118" mass="12796" checksum="36977A09DB363FC6" modified="2008-04-08" version="1">MKNLSILTSLLLTSASLVFSSSIPPKCGTCNPLSGENHCDITTSCINTGTRFHCACRAGYKASKDNHDVSKQFRLNVPNYQFLVFTPESTECNTLCDNPYGASPDLCAEVPIQDKCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSA7</accession>
    <name>B0XSA7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamin biosynthesis protein (Thi-4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_026520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSA7"/>
    <dbReference type="HOGENOM" id="CLU_020520_2_1_1"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="PhylomeDB" id="B0XSA7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="299"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="524" mass="57340" checksum="873815931DF6BBF1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSZ9</accession>
    <name>B0XSZ9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RelA/SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_028370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="B0XSZ9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
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        <property type="entry name" value="GTP PYROPHOSPHATASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="RELA_SPOT DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04607">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="100"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="508" mass="57795" checksum="D2D228E2BF90D30B" modified="2008-04-08" version="1">MVTQHETCMSWSYLLFILSHSETVVKSIAAISNSPIVCRMDKQAKEDLSRSTTPSTSAVIEDFVASYEKHRDFYCHTAIAVRRLCEAALEDHHIPCLVSHRAKEAASLRKKLYARQLLRGHAYASREEIKNDISDLAGVRIALYYPRHGEEVKRILDDELTVVEEKTINRMGMDEALHGGYDRWFPGYCAQHYRVHLKSGPVNQEGVPTHNTKVEIQVVSVLRHVWAEVEHDVVYKGKRRASGDDHRILDGLSGAVFLGECFLDQLYQTQVSRATTDDRGFENVYALGSFLWNWTASLGHCQVEYPVEVEFLKDLLGILGLNHPRTLRDILSQIDLSTRDGSEWHAFRAAFHPARSSLTMFLMHRILTMPAGANRLATTPADDPGIDRAKHELGLISSSLIWLDRVYPLSSQLFGALFASDSWDRYLPGIEWLDSQKAQDYWRGKAVLTDEERQKINVVFQCFTRNRAQPIQLAFALARLGVLRRYAADWLALHRVISPLLIVIQARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT26</accession>
    <name>B0XT26_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_017780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017780"/>
    <dbReference type="HOGENOM" id="CLU_2372376_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="95" mass="10588" checksum="CBB2306E64516D0E" modified="2008-04-08" version="1">MRNRRYEASPQLRRPLLRLGMDTWMSDLSAVSASDWHSSSKLSKALDPALPNSIGAGVETRVITPDGSQGNGDIRQSTRWDDRQLNAQDWASVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT56</accession>
    <name>B0XT56_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_018090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018090"/>
    <dbReference type="HOGENOM" id="CLU_014492_3_0_1"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000119">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF14">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="586"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="650"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="715"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="737"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="801" mass="85686" checksum="1E35A2ED5631F1F4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU05</accession>
    <name>B0XU05_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_019730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019730"/>
    <dbReference type="HOGENOM" id="CLU_1239877_0_0_1"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="PhylomeDB" id="B0XU05"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="7">
        <location>
            <begin position="65"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="223" mass="24560" checksum="03656EA27E147D5E" modified="2008-04-08" version="1">MHGQTRLSRQTRNISRLGVRQNAKAHDIINGRCVDIARSKCTYFGSNEKPLHLSYSAGRLDIHYAVNSKAQQTFIGGVIAFRVLPRPQFSALQTSIFPVYFTLQSALPVVIALTSSKGGQLNGISGLLAPESRFGTLLPLATVAVSGLINQVILRPLTVRTMKERKHQETRDGKKSYDPAPHSKEMMALNKKFGRLHGLSSLINMVSLIATVYYGVVLSKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUA2</accession>
    <name>B0XUA2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_020020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020020"/>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="PhylomeDB" id="B0XUA2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP53956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="410" mass="44784" checksum="59FE10783A35CF70" modified="2008-04-08" version="1">MRLIKNKIEHGGSGTVTLCPEEPEDMWHAYNLIRPGDLLRASAIRRVTTTHDTGTTTSSRVHLTLEIRVKSLDFDPQSSQLHVGGTIVNETPHTKVGQHHTLDLELNRNFTLEKEIGANGEGVGWDSIAVQMLQDAVDESGKRRAEAVAVVMQEGLAHICFIGQFQTVLKQKVEMSVPRKRQGGGGGDHDKGMSKFYQVTLDTLLRQMEFNTSATSLTSNEPVKPVLLASPGFVAAGFQKYIQSVASTTTPALKRLLPSIVVVHSASGYLHSLAEVLQSPAVKTILADTKYARETKLMDDFLGHLRKETNKAIYGPREVEAAVDQGAVGRGGGVLIISNRLFRSQDVAERKRWVSLVDRVRDVEGGEVRVLSSDHESGRRLDGLGGVAALCTFPVVEEDFESDEEPAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW06</accession>
    <name>B0XW06_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH dehydrogenase Oye3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_033650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033650"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="PhylomeDB" id="B0XW06"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="376" mass="42200" checksum="5294519A5771FB5A" modified="2008-04-08" version="1">MREEPSSAQLFKPLKVGRCHLQHRMIMAPTTRFRADGQGVPLPFVQEYYGQRASVPGTLLITEATDITPKAMGYKHVPGIWSEPQREAWREIVSRVHSKKCFIFCQLWATGRAADPDVLADMKDLISSSAVPVEEKGPLPRALTEDEIQQCIADFAQAARNAINAGFDGVEIHGANGYLIDQFTQKSCNHRQDRWGGSIENRARFAVELTRAVIEAVGADRVGVKLSPYSQYLGMGTMDELVPQFEYLIAQMRRLDVAYLHLANSRWLDEEKPHPDPNHEVFVRVWGQSSPILLAGGYDAASAEKVTEQMAAATYTNVAIAFGRYFISTPDLPFRVMAGIQLQKYDRASFYSTLSREGYLDYPFSAEYMALHNFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWP7</accession>
    <name>B0XWP7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylglycerol specific phospholipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_046870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046870"/>
    <dbReference type="HOGENOM" id="CLU_029943_0_0_1"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="PhylomeDB" id="B0XWP7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000052">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000107">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="492" mass="54270" checksum="80E8D9BAC8891C9E" modified="2008-04-08" version="1">MQPKAVQDAHASFPAGKHAADETEHLLPHDPPAEINIWGSRRRPRSWWALVAISLLLLTMTVLSLAVFFTLGFGAGAAPHVPHGRLSSPIKNVVVLVQENLSFDNYAGGLTYSPSIDGLVNRKYCNPANISDPHSPMVCAQPTAKNIAPDDPDHSITGGNQQVYSTYHPDSDFDAPNMQGFVAEQIAAYGIDGNLSRAGEVINYYTPEHIPVFNAMAENFVLFDRWFAAVPGPTNPNRAYLTSGTSHGHGTNDPDFDRSALPQRSIFEQLSEHNISWINYSNTTGFLPDALFYRWTAVSGLGETNVRPIDQFYRDAKAGTLPQFTWINPECCSYMSFHPPSPINMGEGWIKSVYEALRSSPQWHETLFILTFDEHGGFADHVPPPENVPAGDDLTYTETARDGKPSTFAFDRLGIRVPTVLMSPWVGKGVVQNRPADGNGEFTHTSILKFVADLWGLEYLSPRVAWSASFAHLITDTFREDTPATLPEPADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX43</accession>
    <name>B0XX43_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_047670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047670"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="B0XX43"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="263" mass="27921" checksum="BE09D36D75865FBB" modified="2008-04-08" version="1">MHIDTTSHIGGLGSSIGKKLREQGAHLAILYAPFEAARREELLESGYGGGSDAIRTYECDITAPSSVESAFHALEREMIRASSSTQSDVVFPSILINTAGYVSLSDMEMTPPEETMKHLTTNIFGPMLCSQAFARLYFAASKTAEASANPSPPGRIVNIASQAAHVALPRHGAYCASKAAFMASEWGGQGITANSVSPTVVWTALGKKAWGEDSVREAFLKTIPSGRFVLPEEVADAVVFLCQDSSGMVNGADIRVDGGFTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXB8</accession>
    <name>B0XXB8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_037510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037510"/>
    <dbReference type="HOGENOM" id="CLU_009187_1_0_1"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="PhylomeDB" id="B0XXB8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="208"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="385"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="823"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="902"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP52585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="957" mass="108235" checksum="D7104FFA959F52B3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXP2</accession>
    <name>B0XXP2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SNARE-dependent exocytosis protein (Sro7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_038100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXP2"/>
    <dbReference type="HOGENOM" id="CLU_006030_0_0_1"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="PhylomeDB" id="B0XXP2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000848">
        <property type="entry name" value="SNARE-dependent exocytosis protein (Sro7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001351">
        <property type="entry name" value="SNARE-dependent exocytosis protein (Sro7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="7">
        <location>
            <begin position="515"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="938"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="938"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="949"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110967" checksum="56C96BA2EF1D14F0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXS3</accession>
    <name>B0XXS3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_038350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038350"/>
    <dbReference type="HOGENOM" id="CLU_042059_1_0_1"/>
    <dbReference type="OrthoDB" id="5394254at2759"/>
    <dbReference type="PhylomeDB" id="B0XXS3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="398" mass="43108" checksum="8FF8F136B6267D5A" modified="2008-04-08" version="1">MLTAQQQNIPVSSCTAAPPRISTPISIEPSLQIAGNLQHYLSKLGSFRQEKIMAPRRRSSVVKTTHVAHSTIDAAKAASKAEESQLRRVPSPVRFLLVVFNSLLLSSVLFTMTSSVTLGELGRVSKHLEAWWEVGGLMLWKAVEVGLAWVLGFDGRDVLSFTFLAHLPTYSLLWSFYGIRPTTILASYGITLISTAIPFILLRRPSSVHNLRQTASDAVPNRFILQDRPTALYTSVAATAIYSVALYLSYATWLPAYLVVHFENIPDIRLAHTGPAGLPILFLTLLPAGWAARDFLFVSSTGASSSDTSVKSKSANEGEYLVCGVYRRTWGTLSAKTRVLVSRTALLASMIVLNTVFQVAGTVRGVDVPGATMWAAIWGAATVAVGGVFGWIEAVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXX7</accession>
    <name>B0XXX7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_038920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038920"/>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="PhylomeDB" id="B0XXX7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000002">
        <property type="entry name" value="Ccr4-Not transcription complex subunit (NOT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="670"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="847"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="1061"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1345"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="14">
        <location>
            <begin position="1676"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1968"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP52723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2342" mass="260991" checksum="FB9665A2CB6F0267" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY35</accession>
    <name>B0XY35_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_039500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY35"/>
    <dbReference type="HOGENOM" id="CLU_021380_0_1_1"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="PhylomeDB" id="B0XY35"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="661" mass="74525" checksum="F92F05BA229798AC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYL5</accession>
    <name>B0XYL5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_041330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041330"/>
    <dbReference type="HOGENOM" id="CLU_2249489_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="104" mass="11153" checksum="5FDEA5C8FE5F9BDF" modified="2008-04-08" version="1">MAVAPQFEIDLVRLWMVIQCLHIGARIKTFHLAGERIGFGPNLKCPEGRRDHTPETAFANMNARADAAASSITIVVCLTISLRTSQGGVLLGHSSLFIGSPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYL7</accession>
    <name>B0XYL7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_041350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYL7"/>
    <dbReference type="HOGENOM" id="CLU_030809_0_0_1"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="290"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="384" mass="42182" checksum="BF9515339054D768" modified="2008-04-08" version="1">MTMTMTVGDQRLPSGFTQITIQDDPRALLPLLKSQLPHSIPLLRRLQHSLAFPSETARLLTTFPGVEPPSGPWLAAYVDLPRGRETQMTLYSSLERESVDEDKGDKDDKDPAVISTLHGRPENLALARAQLLALLSYTKSALLPGYLASRPARGVGPGPAHAPGQTPPPPPQAFLIGNLHTGLMALLMKSGIYTDPDPEPVPGVRVHRYDNPPYVKYLVRNVQWHSPARKPDPGSPLPPGYRFQDRQGRTGILPHHYALVRSRTHLPRSDETLSRIPGVAAYVDQPGDGEETPIAWVFLGLDGSLATLFVEPEHRGKGIAEALSREVMRRGMAEGGIWREVGEDGEVWVHANVLATNRASRRVLEKLGGEVGWTNTWTVVELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYU5</accession>
    <name>B0XYU5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 zinc finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_042120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042120"/>
    <dbReference type="HOGENOM" id="CLU_318838_0_0_1"/>
    <dbReference type="OrthoDB" id="4501248at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="912" mass="100059" checksum="3007EF707A6D888C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ44</accession>
    <name>B0XZ44_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">20S cyclosome subunit (APC1/BimE), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_043100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043100"/>
    <dbReference type="HOGENOM" id="CLU_000746_0_0_1"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ44"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000217">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="8">
        <location>
            <begin position="1793"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2080" mass="229545" checksum="4B09A77E5E5C2CCC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ85</accession>
    <name>B0XZ85_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_043510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043510"/>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ85"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000014">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3030:FF:000004">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="164"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="308"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="476"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="610"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="809"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="968"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP53181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1116" mass="125799" checksum="39A79132C38E78AD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZD8</accession>
    <name>B0XZD8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_044060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044060"/>
    <dbReference type="HOGENOM" id="CLU_031993_0_0_1"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="589" mass="64112" checksum="C8441877CDE1F40E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZJ3</accession>
    <name>B0XZJ3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_034070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034070"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_1_1"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="PhylomeDB" id="B0XZJ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38077" checksum="3671390042870A95" modified="2008-04-08" version="1">METISSGFHLADGNGFMLDKGYAARCRLNLQFYLWKNSLAFNLHPSIPIPHTHGSPPLRIADLACGTGIWLLDLPCELPEPAVLDGFDIDLSKAPPAQWLPNNVTVHNWDILSPVPEHLVGRYDIVHLRLLILVVQHSDPVPIIQNAYRMLKPGGYIQWDDLNYPDTHVSKANPGADTPAFDRLLQFVRSNGRHDWVLSLPGILERNGFTDARLDHFGDRTELAMAHGDQHLMTMEEFAGSLQQKGMLEEAQNIHQLIADCCQEASPAVALSMAQRPSFQCDPGQASNVVDSSELSDQNKAKDTSQAPAFGALEPGNSPRDLQASLAQDPKQTKSPVRQRHVGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZZ3</accession>
    <name>B0XZZ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitotic spindle checkpoint protein (Mad2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_034890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZZ3"/>
    <dbReference type="HOGENOM" id="CLU_072097_2_0_1"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="PhylomeDB" id="B0XZZ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905318">
        <property type="term" value="P:meiosis I spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000026">
        <property type="entry name" value="Mitotic spindle checkpoint protein (Mad2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP52325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="141" mass="15858" checksum="03D6E86A55A9EC2F" modified="2008-04-08" version="1">MYGSPLNGCVQRLIRIYYHQVQIFGKHAKSQTSRKSADKENATPGDTENQSSTAVEKTEKEIQEEIQAIFRQITASVTFLPVLDGDCTFNVLVYADADSDVPVEWGDSDAKEIKNAEKVQLRSFSTNNHRVETLVSYRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0M8</accession>
    <name>B0Y0M8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_057870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0M8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057870"/>
    <dbReference type="HOGENOM" id="CLU_040088_4_0_1"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0M8"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="284" mass="30960" checksum="B5F7854CDD043F5D" modified="2008-04-08" version="1">MASNRALAILDHAASNHYGVPAMCCYNLEGILATVRAAEAKRSPAMILLFPWAIHYADGLLVHAAAEAARKASVPIAVHMDHAQTPEIIRYAADLGGFDSIMVDMSHYDKEENLRLTRELVAYCHERGIATEAEPGRIEGGEDGVADTADLEGLLTTPEESREFADTGIDWLAPAFGNVHGEYGPRGIRLEYDRLKSIQEAVGDRVKLVLHGADPFTPEIFAQCIECGVSKVNLNKVLNNEYVRVQREKSGRAPLTAVLEEATNEMQKAVERCMDMLGSTGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0Z1</accession>
    <name>B0Y0Z1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_059020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0Z1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059020"/>
    <dbReference type="HOGENOM" id="CLU_042569_3_0_1"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0Z1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="480" mass="52237" checksum="284F1E8E834FBB37" modified="2008-04-08" version="1">MNKQSSARVEPAISAANHVVSKQAVVRTQDTTPYSPLERLYYPALSIQSLSAQYASCAYTGSHDWSNTFHYSDGVRCTTSGSFIAKPCTPQEVAFYESSAFHPAFRDFIPTYIGTLSSADQQGPLALTAAAQQSGAIVLPTADDSSSSATPTTAEAPQLGLQAGLGSNGTTENKPWVPSGGKKLETGLSIVLENIASGFKRPNVLDVKLGARLWADDAPPAKRAKLEAVAKETTSGSLGFRIAGMKIWTGAHGETDEGSKTNPYATKHEGSEGARGKIVEKDGYKRYDKWYGRSFNEKNVKEGFETFLAGAKAGPVDRSKLIAKRLADELRRVQSILESEESRMYSSSVLIVYEGDPEAMEQALEEEKKPRDRSPEEADEEDEDFDFALQGDGSFEVVNLRVGQEGIPQQAINMNLGPETAQFGEIDFEDEEEEDDPPKVHDLRLIDFAHASWTPGQGPDENVLMGVRSLIRLLDELAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y145</accession>
    <name>B0Y145_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_059570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y145"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059570"/>
    <dbReference type="HOGENOM" id="CLU_035382_3_0_1"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="PhylomeDB" id="B0Y145"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP51936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="419" mass="47317" checksum="9EC4C705154B90C2" modified="2008-04-08" version="1">MQLHRINTMDLKHSLRDLCMNPRHTSWAAPLLILGDAVLCALIIWRVPYTEIDWTTYMQQISLYISGERDYTLIKGSTGPLVYPAAHVYIYNILYHLTDEGRDIFLGQILFAILYLATLTVAMTCYRQAGAPPYLLVPLVLSKRLHSVFMLRLFNDGIAAFAMWVSIFLFMNKKLAAGVIVWSTGVAIKMTLLLLAPAIAMVLVLSLSFGPSIRLGFLAVLIQVLFGIPFLRNNPAGYVSRAFELTRQFMFKWTVNWRFVGEELFLSRKFSLALLALHLLLLGLFVATVWLEPSGSNLPSFLQRLIQRRYRTASLSKSFVMTAMLSSLAIGLLCARSLHYQFFAYLACATPFLLWQAGFHPILVYVVWAAQEWAWNAYPSTNASSLVVVLSLAAQVFGVLGNSFSRKHLDQSSQKEHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y155</accession>
    <name>B0Y155_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_048740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y155"/>
    <dbReference type="HOGENOM" id="CLU_006237_1_0_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="PhylomeDB" id="B0Y155"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="751" mass="84456" checksum="FE0B01B954592AA5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1J5</accession>
    <name>B0Y1J5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_049520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1J5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049520"/>
    <dbReference type="HOGENOM" id="CLU_1517528_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0Y1J5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="177" mass="20112" checksum="EF95234E2254E5C4" modified="2008-04-08" version="1">MTPSTSQKSIRLPPASRLRDLPPVPVYDVTKFPDPRTQKLRSLLEQGHVTVAPLRDPELILHSHLPHTYGYESRPLTFGLQLLGSAYALGADSDQLTRTYEHEITQLVPIARGFIRGEAISKENWRDFLTRKEYTMAYQDFFDNEVKEKQGDWGKVLEEYLYSGTEPLVNGCTGGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2W8</accession>
    <name>B0Y2W8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cdc48-dependent protein degradation adaptor protein (Shp1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_052130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2W8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052130"/>
    <dbReference type="HOGENOM" id="CLU_029402_4_1_1"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2W8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000020">
        <property type="entry name" value="NSFL1 (p97) cofactor (p47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000179">
        <property type="entry name" value="Plant UBX domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SEP" evidence="4">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="313"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="394" mass="42476" checksum="9C527B0420AB6A2A" modified="2008-04-08" version="1">MERNPAENDEVVSQFCAMTGTRPAEAQEYLAANGWDIEAAVTEFFAEQDEAMLGANTAGGRSLGGAESAASAGRSLGGSSSQSGTATPKQSSSSSRKPTSKKRFATLGDFASGGGDFSDEDDTENQDFFAGGEKSGLAVQNPDDLKRKIIEKARKTQLPSSDEPQTRRSYFTGTARTLGGDDTPSRVIESPSAPTLQRPQRVQRTLHFWADGFSVDDGDLFRSDDPRNAEILDGIRQGRAPLSIMNVQPGQEVDVEIKQHEEKYVKPKPKYKPFSGTGQRLGSPTPAVRSQAPSEAPAPSQPSAESVKPDVDESQPIVTLQIRLGDGTRLTSRFNTSHTIGDVYQFVSAASPSSQSRPWVLMTTFPNKDLTDKSAVLGDLPEFKRGGVVVQKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2Z1</accession>
    <name>B0Y2Z1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class III chitinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_052360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2Z1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052360"/>
    <dbReference type="HOGENOM" id="CLU_060983_2_0_1"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2Z1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06546">
        <property type="entry name" value="GH18_CTS3_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="11"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="383" mass="42827" checksum="3A7478D62B194F43" modified="2008-04-08" version="1">MPPVPGRPEHRRVICYHQTLCPNRGDYVSVLPLVKNNTGVTHIIIAAFHLNEDPGHITLNDDPPDHEMYNPLWAEVPVLKRSGVKVMGMLGGAAQGSYRCLDGDQEKFERYYQPLLAMVRRHQLDGLDLDVEEEMSLPGIIRLIDRLKLDLGDDFIITLAPVAAALLGIGNLSGFDYRQLEQQRGSKISWYNAQFYNGWGLAEDPRMYAAIVAQGWSPQRVVYGLLTNPGNGSQGYVPRERIGPVLAVLVEQFPNFGGVMGWEYFNSIPGEQQSPWQWAAEMSLSMHMKDVLAAARQMLTAGPMANSLMNVLRDMMHQPHFIAPTDSSVRRMIWSMAMETGIYQSIAAHVVIPPITHSPLSFDVRCTRSFVTVSPRFTPVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y353</accession>
    <name>B0Y353_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3b, subunit 2, 145kD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_052980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y353"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052980"/>
    <dbReference type="HOGENOM" id="CLU_014435_1_1_1"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="PhylomeDB" id="B0Y353"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="554" mass="63099" checksum="136FADFCDEB4610A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y369</accession>
    <name>B0Y369_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_053140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y369"/>
    <dbReference type="HOGENOM" id="CLU_009116_6_4_1"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="PhylomeDB" id="B0Y369"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04247">
        <property type="entry name" value="AAK_AK-Hom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04934">
        <property type="entry name" value="ACT_AK-Hom3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000033">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041747">
        <property type="entry name" value="AK-Hom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="56935" checksum="8AF9EC6C4A4DF3F0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y382</accession>
    <name>B0Y382_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_053270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y382"/>
    <dbReference type="HOGENOM" id="CLU_027445_2_0_1"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="PhylomeDB" id="B0Y382"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="12">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="13">
        <location>
            <begin position="341"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="341"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="414" mass="47267" checksum="7DEE86ED9F65E4A7" modified="2008-04-08" version="1">MAAELTSTKLNAENHLLLVNPTTAHDQPLLRLPHELARRNFKSVQRLVEREREYVIPALKEAANASLSNAQTPDQTLAALDSMLARMQNLKRKMESIQQEEKKVQNQSRKRIQHLEHLHQIPSLADVKYDQWSRIRLDRLVVDHMLRSGYTESAQQLAQEKGIEDLVDLDVFVQCQRIAQSLRRGETKDALQWCNENKAALKKSQFNLEFELRLQQYIEMLRTGDRGKLMDAMAHAKRYLTPYTETQSKEIHRAAGLLAFPQDTKAEPYKLTDLQSMYSFDRWNYLSDLFIRTHHELLSLPSSPLLHIALSAGLSALKTPSCHSAYTSSSSNSLSTTTSVCPICSTELNELARNMPYAHHAKSYVESDPIVLPNGRIYGQQRLLDMSKKLGCVETGKLWRYQNVEAAACFHILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3B0</accession>
    <name>B0Y3B0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">AFUB_053550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3B0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053550"/>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3B0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="247" mass="26587" checksum="9D1DEB37395DAC71" modified="2008-04-08" version="1">MAVRAQFENSNEVGVFARLTNSYAIVAIGASENFYSVFEAELQDVIPICHATIAGTRIVGRLTAGNRKGLLVPTTTTDQELQHLRNTLPDDVKIQRIEERLSALGNVICCNDHVALVHPDLERETEEIIADVLGVEVFRQTIADNVLTGSYMALSNQGGIVHPKTSIRDQDELSSLLQVPLVAGSVNRGSPVVGAGMVVNDWLAVTGLDTTATELSVVESVFRLGEMGPRGLGVGNANKESIVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3N0</accession>
    <name>B0Y3N0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_054790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_016396_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="647"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="647" mass="71087" checksum="92DC26E1FCFDD2D0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y442</accession>
    <name>B0Y442_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">3-methylcrotonyl-CoA carboxylase subunit alpha (MccA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_056440</name>
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    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
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        </cofactor>
    </comment>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
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    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PreATP-grasp domain"/>
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    </dbReference>
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        <property type="entry name" value="Rudiment single hybrid motif"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="32"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="756" mass="83067" checksum="D0DBC4A7EB97DCA5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y453</accession>
    <name>B0Y453_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved glutamic acid rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_056550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="485"/>
            <end position="539"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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            <end position="363"/>
        </location>
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            <end position="459"/>
        </location>
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            <end position="584"/>
        </location>
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            <end position="24"/>
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    </feature>
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        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
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        </location>
    </feature>
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        <location>
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            <end position="300"/>
        </location>
    </feature>
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            <end position="344"/>
        </location>
    </feature>
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            <end position="355"/>
        </location>
    </feature>
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            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP51644.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="609" mass="72457" checksum="1A158E81994DEA13" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4A9</accession>
    <name>B0Y4A9_ASPFC</name>
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        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
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        </recommendedName>
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        <name evidence="6" type="ORF">AFUB_057110</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="141"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="211"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP51700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="224" mass="23143" checksum="23C811A2BC993E3E" modified="2008-04-08" version="1">MSTSTPVKLSFEAIDDLIYDARAGDLEALKADLATQSKEHNCPEAWIIASAIDAEAEAEGGTGSCLLHFPAANGNAEILNYLLATLTAQSAAPLSAEQIAAVVNHRNHSGNTPLHWAALNTHLGCVKALVEAGADIGVKNDAGLDAIFLAERTAWSTEEEGKEVPAEEEGAGKMSKGRQVVEWLLSSDKAGDLEEGLSVSAGVGAEGSASGSGSGETMDVDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4J2</accession>
    <name>B0Y4J2_ASPFC</name>
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        <submittedName>
            <fullName evidence="3">Toxin biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AFUB_069280</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP50591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="445" mass="50394" checksum="1A0D37DB3B1BFF74" modified="2008-04-08" version="1">MSSSSSSISGPFRIVEHVVECQHIREYPAATANEQEDVLHLAVKQYIPLDNPDPQPGDVTILAAHANGFPKELYEPLWEEIYARSKANGFRIRSIWMADVAHQGQSSVLNEDLLGNDPSWFDHPRDLLHLVNVKRKEMPRPIVGIGHSMGGAHLTQLSLMHPRLIHTLVLLDPVIQRQTTQLEPRPLSKDQFIIAKTTQLSTYRRDKWPSRKAAAEAFKKNPFYQTWDPRVLDRWIKYGLRDLPTAVHPLDDGAASQGNDRPVTLTTTLHQEVFTFSRPNYDGPPGKNVPINRVTHPDLNPKHVGSFPFYRPEPSRIFAQLEHLRPSVLYIFAGKSDMCLPEMMADKMKNTGTGLGGSGGAAEGRVRDVYLKKYGHLLAQEAPSECGEAASRWLGKELERWRAEEQAFREQWSKKSKIEKATIDSRWKEHVPAPVRPKKDSEAKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4X4</accession>
    <name>MPKA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase mpkA</fullName>
            <shortName evidence="11">MAPK mpkA</shortName>
            <ecNumber evidence="12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mpkA</name>
        <name type="ORF">AFUB_070630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="618" last="627">
            <title>The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response.</title>
            <authorList>
                <person name="Valiante V."/>
                <person name="Heinekamp T."/>
                <person name="Jain R."/>
                <person name="Haertl A."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="17981060"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.09.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PHOSPHORYLATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="909" last="918">
            <title>The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Valiante V."/>
                <person name="Jain R."/>
                <person name="Heinekamp T."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="19715768"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2009.08.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="82" first="39" last="53">
            <title>The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Jain R."/>
                <person name="Valiante V."/>
                <person name="Remme N."/>
                <person name="Docimo T."/>
                <person name="Heinekamp T."/>
                <person name="Hertweck C."/>
                <person name="Gershenzon J."/>
                <person name="Haas H."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="21883519"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07778.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PHOSPHORYLATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Mol. Microbiol." volume="100" first="841" last="859">
            <title>Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence.</title>
            <authorList>
                <person name="Bruder Nascimento A.C."/>
                <person name="Dos Reis T.F."/>
                <person name="de Castro P.A."/>
                <person name="Hori J.I."/>
                <person name="Bom V.L."/>
                <person name="de Assis L.J."/>
                <person name="Ramalho L.N."/>
                <person name="Rocha M.C."/>
                <person name="Malavazi I."/>
                <person name="Brown N.A."/>
                <person name="Valiante V."/>
                <person name="Brakhage A.A."/>
                <person name="Hagiwara D."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="26878695"/>
            <dbReference type="DOI" id="10.1111/mmi.13354"/>
        </citation>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2019" name="MBio" volume="10" first="0" last="0">
            <title>Mitogen-activated protein kinase cross-talk interaction modulates the production of melanins in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Manfiolli A.O."/>
                <person name="Siqueira F.S."/>
                <person name="Dos Reis T.F."/>
                <person name="Van Dijck P."/>
                <person name="Schrevens S."/>
                <person name="Hoefgen S."/>
                <person name="Foege M."/>
                <person name="Strassburger M."/>
                <person name="de Assis L.J."/>
                <person name="Heinekamp T."/>
                <person name="Rocha M.C."/>
                <person name="Janevska S."/>
                <person name="Brakhage A.A."/>
                <person name="Malavazi I."/>
                <person name="Goldman G.H."/>
                <person name="Valiante V."/>
            </authorList>
            <dbReference type="PubMed" id="30914505"/>
            <dbReference type="DOI" id="10.1128/mbio.00215-19"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2021" name="Genetics" volume="0" first="0" last="0">
            <title>Transcriptional control of the production of Aspergillus fumigatus conidia-borne secondary metabolite fumiquinazoline C important for phagocytosis protection.</title>
            <authorList>
                <person name="Rocha M.C."/>
                <person name="Fabri J.H.T.M."/>
                <person name="da Silva L.P."/>
                <person name="Angolini C.F.F."/>
                <person name="Bertolini M.C."/>
                <person name="da Cunha A.F."/>
                <person name="Valiante V."/>
                <person name="Goldman G.H."/>
                <person name="Fill T.P."/>
                <person name="Malavazi I."/>
            </authorList>
            <dbReference type="PubMed" id="33705521"/>
            <dbReference type="DOI" id="10.1093/genetics/iyab036"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH FMQA AND FMQC</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7 9 10">Mitogen-activated kinase (MAPK), part of the cell wall integrity (CWI) signaling pathway composed by three protein kinases bck1, mkk2 and mpkA and responsible for the maintaining of cell-wall integrity balance (PubMed:17981060, PubMed:19715768). The CWI pathway also regulates the oxidative stress response, as well as the production of some secondary metabolites including gliotoxin, pyomelanin, pseurotin A, fumiquinazoline C or dihydroxynaphthalene (DHN)-melanin (PubMed:19715768, PubMed:21883519, PubMed:30914505, PubMed:33705521). MpkA directly phosphorylates the fumiquinazoline C biosynthesis cluster nonribosomal peptide synthetase fmqC during conidiation (PubMed:33705521). Mpka is also required for adaptation to iron starvation and regulates the expression of genes involved in siderophore biosynthesis in a hapX/sreA-independent manner (PubMed:21883519).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with the fumiquinazoline C biosynthesis cluster nonribosomal peptide synthetases fmqA and fmqC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <text evidence="7">Accumulates in the nucleus under iron depletion conditions.</text>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is induced by cell wall integrity inhibitors such as glucanex, SDS, congo red and caffeine.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5 7 8">Phosphorylated during cell wall stress by the upstream MAPKK mkk2 (PubMed:17981060). Iron starvation triggers phosphorylation and thus activation of mpkA (PubMed:21883519). Phosphorylation increases upon osmotic stress and cell wall damage and depends on mpkC and sakA (PubMed:26878695).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6 7 10">Leads to the formation of thicker hyphae, which appear less elongated and form more branched hyphae (PubMed:17981060, PubMed:19715768). Increases sensitivity to diamide and menadione but shows increased tolerance against H(2)O(2) (PubMed:17981060). Results also in increased sensitivity to cell wall integrity inhibitors such as glucanex, SDS, congo red and calcofluor white (PubMed:19715768). Affects the expression of genes involved in cell wall remodeling, protection against ROS, secondary metabolism such as gliotoxin, pyomelanin and pseurotin A, as well as genes involved in siderophore biosynthesis (PubMed:21883519). Also affects the expression of fumiquinazoline C biosynthesis cluster genes (PubMed:33705521). Does not affect the formation of conidiophores and conidia, nor the germination of aconidia (PubMed:17981060). Does not affect the virulence in a low dose murine infection model (PubMed:17981060).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="12"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4X4"/>
    <dbReference type="SMR" id="B0Y4X4"/>
    <dbReference type="EnsemblFungi" id="EDP50723">
        <property type="protein sequence ID" value="EDP50723"/>
        <property type="gene ID" value="AFUB_070630"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070630"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4X4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902413">
        <property type="term" value="P:negative regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905665">
        <property type="term" value="P:positive regulation of calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032995">
        <property type="term" value="P:regulation of fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000454881" description="Mitogen-activated protein kinase mpkA">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17981060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="19715768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="21883519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="26878695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="30914505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="33705521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="17981060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="17981060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP50723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="424" mass="48466" checksum="06E39C8E15D5A6CB" modified="2008-04-08" version="1">MSDLQGRKVFKVFNQDFIVDERYNVTKELGQGAYGIVCAATNVHTGEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSIDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHYLGTPNEETLSRIGSPRAQEYVRNLPFMPKIPFQRLFPNANPDALDLLDRMLAFDPASRISVEEALEHPYLHIWHDASDEPTCPTTFDFHFEVVDDVQEMRKMIYDEVVRFRNLVRQQSQAQAAAAAQQQQQQIAQQTNVPIPDHQQGGWKQEEPKPQEVHAAGGHVNDLESSLQRGMDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y504</accession>
    <name>B0Y504_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_070940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y504"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070940"/>
    <dbReference type="HOGENOM" id="CLU_431448_0_0_1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B0Y504"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="634" mass="70120" checksum="D840157A1EA6B1B6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5D8</accession>
    <name>B0Y5D8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monothiol glutaredoxin-5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_063050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP49973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5D8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063050"/>
    <dbReference type="HOGENOM" id="CLU_026126_2_0_1"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5D8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="153" mass="17080" checksum="F9AE608F57621D36" modified="2008-04-08" version="1">MMFQRQAFAPAFRPFSRSPLVLTPRFTAFQLPHALHARFLSEQTRSAIDKAIASAPVVLFMKGTPETPQCGFSRASIQILGLQGVDPKKFVAFNVLEDPELRQGIKEYSDWPTIPQLYLDKEFIGGCDILMSMHQNGELAKLLEEKGVLVAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5K4</accession>
    <name>B0Y5K4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_063700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063700"/>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_1"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5K4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="190"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="9">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="458" mass="49368" checksum="D462BF2942CBAE35" modified="2008-04-08" version="1">MSNLPHEPEFEQAYKELASTLENSTLFEKNPEYRKALAVVSVPERVVQFRVVWEDDNHQVQINRGYRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDNEIRRFCVAFMTELCKHIGADTDVPAGDIGVTGREIGFLFGQYRKIRNQWEGVLTGKGGSWGGSLIRPEATGYGLVYYVDHMIKYVTKGAESFAGKRVAISGSGNVAQFAALKVIELGGSVVSLSDSKGSLVVNGEGSFTPAEIDIIAQLKVDRKQLSEVATTEAFATKFKYIEGARPWVHVGKVDVALPSATQNEVSGEEAQALIDAGCKFIAEGSNMGCTQAAIDIFEAHRQANPGAAAIWYAPGKAANAGGVAVSGLEMAQNSARISWTAEEVDSRLKDIMESCFRNGLDTAVKYATPAEGVLPSLVTGSNIAGFTKVAEAMKEQGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5L8</accession>
    <name>B0Y5L8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron-sulfur cofactor synthesis protein (Isu1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_063840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5L8"/>
    <dbReference type="HOGENOM" id="CLU_079283_1_2_1"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5L8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="8">
        <location>
            <begin position="119"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="255" mass="27505" checksum="987394D01980CFE3" modified="2008-04-08" version="1">MFRRLATVAPRSVGAVASPRIAPAISGIQSQPINRASPTPQRRNYHEKDKYIDQSGMTSQMLTFFALLDHYNNPRNEDCYDQSTSICLLCARGESRVSAFFKLLTNHVHASETDISIVGSLPKDAPDVGLGLVGAPACGDVMKLQIRVDKDTSKITDVKFKTFGCGSAIASSSYLTELVRGMTLDEAAKIRNTDIAKELCLPPVKLHCSMLAEDAIKSAINDYYTKNPKAAKTDLSGTAASISNVEKTDGSTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Z9</accession>
    <name>B0Y6Z9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine Rich Repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_068710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6Z9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068710"/>
    <dbReference type="HOGENOM" id="CLU_025206_1_0_1"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6Z9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="647" mass="71035" checksum="AA1EA92CED3B4049" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y771</accession>
    <name>B0Y771_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF647 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_072780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y771"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072780"/>
    <dbReference type="HOGENOM" id="CLU_015325_5_1_1"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="PhylomeDB" id="B0Y771"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="90"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="542" mass="59143" checksum="D52282BD65F2DB57" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7F4</accession>
    <name>B0Y7F4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_073620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073620"/>
    <dbReference type="HOGENOM" id="CLU_1119943_0_0_1"/>
    <dbReference type="OrthoDB" id="4755622at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="248" mass="27343" checksum="92415BADE6E544DB" modified="2008-04-08" version="1">MGRTSSVRRRRDPPPLHSRAPPSSPPPSTASEQSVETEWKEIACHTAKCDMCNTRNGTGMSRCEGCGWQACYKCILANGPSRTHRGNGRVHTGAIDQVLVARMRRGRVTVKREEDDAGQLKRRKSSNLKRMKKEESSSKIPSAADDEVLIAARNVFAFSIEAIGLAIQEDGLVREHSPGGATHRDQDVANFTSMTSRELHDYAQQQASHALQTYLERRARKTDAPEIGTFSVTQANVDETILAENSKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7I1</accession>
    <name>CRED_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable HECT-type ubiquitin ligase-interacting protein creD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Carbon catabolite repressor D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">creD</name>
        <name type="ORF">AFUB_073890</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the arrestin family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP49362" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49362.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7I1"/>
    <dbReference type="SMR" id="B0Y7I1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073890"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7I1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031396">
        <property type="term" value="P:regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000018">
        <property type="entry name" value="HECT-type ubiquitin ligase-interacting protein creD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000395696" description="Probable HECT-type ubiquitin ligase-interacting protein creD">
        <location>
            <begin position="1"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="601" mass="66388" checksum="75694E26A6B84798" modified="2010-07-13" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7J5</accession>
    <name>B0Y7J5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_074030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7J5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074030"/>
    <dbReference type="HOGENOM" id="CLU_012062_29_0_1"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7J5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000542">
        <property type="entry name" value="Putative rnp domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="370" mass="38352" checksum="6C7BA8B9D2B1630F" modified="2008-04-08" version="1">MSFPPPPGLKQTSSSLPARPPPSASTAAASYQPAYSAAPSYTAPAASSGYGGAGSGTGYNAFTAFQPRAVASSQPYRTSSPAVSTPPAAATGYSAPAAANYGSYYSQTPQTYQGGPTYYGSSQYSDATYGPSVPHIQNPFTATGTGKNYGRNDSGLDPETEAQIAQWQSAYANKEEAPGGKVAGRRDGATGMPGATVGTNTPTSATATSTPTPASHPEQNAKTVVRSGGGQTWTDPTLLEWDPAHFRLFVGNLAGEVTDDSLLKAFSRYSSVQKARVIRDKRTQKSKGYGFVSFSNGDDYFAAAREMQGKYIGSHPILLRRATTEIRPTTNPKAGKKNAGGHSGGQAGGKVKHDGVKKPSKTRGGLKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7U5</accession>
    <name>B0Y7U5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_075030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7U5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075030"/>
    <dbReference type="HOGENOM" id="CLU_036827_0_0_1"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7U5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760858" evidence="3">
        <location>
            <begin position="18"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="42"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="436" mass="48716" checksum="5A3B67A9EEE76624" modified="2008-04-08" version="1">MFHSAVSALLSLIRAFAGSLIVQRKSSESKPYSAVTVQIEVLTSEQYEIEDSSGIVDLIEAIRIQSSGPTEASRALRKKLKYGNLHRQLRALTILDFLIQNAGDRFLREFADEPLLERLRIAATDPVSDPLVKQKCKQLFGQWAVSYKDTPGMEGVTALYRQLPKRKQPATQAKAKVLRDTGDSTNEPQLGHTVSISVGNGPTTVLSSPKHKHTSSKSSFKRDKKEKEKKIHNRSFSLEREKPEMLQTLASSSVASTNLLNALKRVNRETHRVSEDAECLNRFETCKLLRRQILRYIQHVESEEYLGSLIHANEELVTALMAFEVLDKSIDYDSDSDQDVLESGWTPDRDDINESFAGLVINPPKPPRPPRPLSISVPSSSQQKYVSASESETDEDDDDENNPFGDRNAIRTPGLEKAEPTWYVLFADLPGAHSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7X0</accession>
    <name>B0Y7X0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_075300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7X0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075300"/>
    <dbReference type="HOGENOM" id="CLU_019189_9_1_1"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7X0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="538" mass="61357" checksum="796D921DBF9040BC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y885</accession>
    <name>B0Y885_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_076460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y885"/>
    <dbReference type="HOGENOM" id="CLU_001287_0_0_1"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="PhylomeDB" id="B0Y885"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000639">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="12">
        <location>
            <begin position="402"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="866"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP49616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="958" mass="107608" checksum="7BCBA498B8DAF672" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8S1</accession>
    <name>B0Y8S1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase activating protein (BUD2/CLA2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_078340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8S1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078340"/>
    <dbReference type="HOGENOM" id="CLU_003244_0_1_1"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8S1"/>
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    <proteinExistence type="predicted"/>
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            <begin position="1136"/>
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        <location>
            <begin position="133"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="201"/>
            <end position="210"/>
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        <location>
            <begin position="539"/>
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        <location>
            <begin position="1249"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50018"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP49802.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1266" mass="142114" checksum="BF4EB05F834039F7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-05-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8Y9</accession>
    <name>HAC5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Subtelomeric hrmA-associated cluster protein AFUB_079030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AFUB_079030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2019" name="Nat. Microbiol." volume="4" first="2430" last="2441">
            <title>Fungal biofilm morphology impacts hypoxia fitness and disease progression.</title>
            <authorList>
                <person name="Kowalski C.H."/>
                <person name="Kerkaert J.D."/>
                <person name="Liu K.W."/>
                <person name="Bond M.C."/>
                <person name="Hartmann R."/>
                <person name="Nadell C.D."/>
                <person name="Stajich J.E."/>
                <person name="Cramer R.A."/>
            </authorList>
            <dbReference type="PubMed" id="31548684"/>
            <dbReference type="DOI" id="10.1038/s41564-019-0558-7"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the subtelomeric hrmA-associated cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting in a loss of vertically aligned polarized growing filaments (PubMed:31548684). Consequently, this hypoxia-typic morphotype (called H-MORPH) with altered biofilm architecture leads to increased hypoxia fitness, increased host inflammation, rapid disease progression, and mortality in a murine model of invasive aspergillosis (PubMed:31548684).</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is regulated by the hypoxia responsive morphology factor A (hrmA).</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblFungi" id="EDP49870">
        <property type="protein sequence ID" value="EDP49870"/>
        <property type="gene ID" value="AFUB_079030"/>
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    <dbReference type="HOGENOM" id="CLU_035142_2_0_1"/>
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    <dbReference type="PhylomeDB" id="B0Y8Y9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF5">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
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    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000460424" description="Subtelomeric hrmA-associated cluster protein AFUB_079030">
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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            <begin position="525"/>
            <end position="559"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <begin position="300"/>
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    </feature>
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        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="31548684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="31548684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP49870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="559" mass="63492" checksum="72B3985E64130AC4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y921</accession>
    <name>B0Y921_ASPFC</name>
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        <submittedName>
            <fullName evidence="4">AMP-binding enzyme, putative</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">AFUB_079350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_002220_3_3_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="544" mass="60621" checksum="DB0E8DE2A6582545" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9C3</accession>
    <name>B0Y9C3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080520"/>
    <dbReference type="HOGENOM" id="CLU_092535_0_0_1"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9C3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="202" mass="22303" checksum="DF1475024A0A68AF" modified="2008-04-08" version="1">MPLIVKFPKFHPLSIYTLIIIIIIIIIIIVIIIIIIIIMASGLIFDPLQLLRVAPLATSTGSLVHALVELFSNSAFLQPSIRKPSDAVLPKWYSYVFNRQIVSVLALNLTTISTGISNILLSRSRSALPLSRTTFYWAGVAGAVAHLFFVPFVAPRIQRIVEDSNANGPTVDMEDWLGFHRIRMLVADLPAWLAFAGAVMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9H8</accession>
    <name>B0Y9H8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 alkane hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_081090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9H8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081090"/>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="PhylomeDB" id="B0Y9H8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP48671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="580" mass="65903" checksum="ACC75E78C743EBF1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9I4</accession>
    <name>B0Y9I4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_081160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9I4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081160"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9I4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="404" mass="44172" checksum="8DF55E1495EE0677" modified="2008-04-08" version="1">MASQVDGKYAWIVVAAVFWNNAHHWGILSSYGVFLAYFISHSTFSGSRTLDYAFIGGLSASQALIISPLVTILHRRFGLRATMAIGILLETAAFLGASWSNKIWQLYLSQGVCFGWGLGLQYLSTTYLIPQWFSRKRSLAAGIATGGSGTGGLIYSLATHAMLARFSIGWSYRILAICQLVVNSFCLLVIRDRSAQDHSSSRTLKINFSLCARYEMWLYIGWSFLSVMGFMVIWFSLATYGRSVGLTSTQGAVVTAVMNIGQMFGRPAVGLLSDAVGRINVAAFATFVSGLLCLLLWTFARTYSALICFALFAGAFFGTFWTVVGPLAAEVVGLADLQSCLTIMWFICAIPATCRSPHILECVCYLLTEQSGKQSALDFGLPDLMSSSERNFSLDLCISELLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9X9</accession>
    <name>B0Y9X9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_082640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9X9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082640"/>
    <dbReference type="HOGENOM" id="CLU_033727_0_0_1"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9X9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="547" mass="57907" checksum="0AF3399E2E85D4B8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA44</accession>
    <name>B0YA44_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_083360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083360"/>
    <dbReference type="HOGENOM" id="CLU_980406_0_0_1"/>
    <dbReference type="OrthoDB" id="5425130at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="270" mass="29706" checksum="B06D44F9FE1DB5AC" modified="2008-04-08" version="1">MAILQKENRPRGLRVPSLSAFKSKKAIDHEPAPAATPVSTAPSAAAPAPPAPVAPPQYPVRTDSAPIRPARPQNDKELPPNPLPAFPPTSASLGPEDIHPAFRNEPSAARNHNYAPPTRARDEPPVQIPTQQTSSSESSVPPDAGDPLEDFIPDPEPEPEHEPELDAASGRLDSVSSDEHNGPFTPPEIEPVTVPLNRLHYACFQEHRSMMPANNVWYSLPCMTCQKFDREMRYRCVFCCLRICADCYQSLQKVPNRSLARLMETMPANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA64</accession>
    <name>B0YA64_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZIP family zinc transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_083560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA64"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083560"/>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="PhylomeDB" id="B0YA64"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="444"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="223"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="462" mass="50141" checksum="2B4787EE2DA2EA3E" modified="2008-04-08" version="1">MGQLTQWLQPNMAASALNRGMPLVSDFPDSILRAELSRRNEIRGSTSDRVACGSKEKGAYNTQIHVLALFLILVLSTLACSFPVLARRFPRLPIPRHFLFISRHFGTGVLIATAFVHLLPTAFVSLTDPCLPRFWSETYRAMAGFVAMISVFLVVVVEMFFATKGAGHVHGSEYDHLIGSVGRGSSESVRDDANYLRLGRHHSTENLRLNLIQANIYADGAQEQSSSLSRMSTDGVEQSRSKKMEPYGETGDAEFGGIDSLDNHSHSPVSDSHPRYLPSQQRDLHPKSSPVLPMQSPQRQLLQCLLLEAGILFHSIFIGMALSVATGTSFVVLLVAICFHQTFEGFALGSRIASLIPDLFSPSSPKPWLMSLAYGTTTPVGQAIGLVLHNLYDPASTTGLLMVGITNAVSSGLLLFAGLVELLAEDFLSESSYATLRGRRRIEACIAVASGALLMAFVGAFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA65</accession>
    <name>ER10B_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acetyl-CoA acetyltransferase erg10B, cytosolic</fullName>
            <ecNumber evidence="8">2.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acetoacetyl-CoA thiolase erg10B</fullName>
            <shortName evidence="11">ACAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cytosolic thiolase erg10B</fullName>
            <shortName evidence="11">CT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ergosterol biosynthesis protein 10B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">erg10B</name>
        <name type="ORF">AFUB_083570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Med. Mycol." volume="43" first="S313" last="S319">
            <title>The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Ferreira M.E."/>
                <person name="Colombo A.L."/>
                <person name="Paulsen I."/>
                <person name="Ren Q."/>
                <person name="Wortman J."/>
                <person name="Huang J."/>
                <person name="Goldman M.H."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="16110826"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="PLoS Pathog." volume="3" first="e24" last="e24">
            <title>Essential gene identification and drug target prioritization in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Hu W."/>
                <person name="Sillaots S."/>
                <person name="Lemieux S."/>
                <person name="Davison J."/>
                <person name="Kauffman S."/>
                <person name="Breton A."/>
                <person name="Linteau A."/>
                <person name="Xin C."/>
                <person name="Bowman J."/>
                <person name="Becker J."/>
                <person name="Jiang B."/>
                <person name="Roemer T."/>
            </authorList>
            <dbReference type="PubMed" id="17352532"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.0030024"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="E497" last="E504">
            <title>Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.</title>
            <authorList>
                <person name="Yasmin S."/>
                <person name="Alcazar-Fuoli L."/>
                <person name="Gruendlinger M."/>
                <person name="Puempel T."/>
                <person name="Cairns T."/>
                <person name="Blatzer M."/>
                <person name="Lopez J.F."/>
                <person name="Grimalt J.O."/>
                <person name="Bignell E."/>
                <person name="Haas H."/>
            </authorList>
            <dbReference type="PubMed" id="22106303"/>
            <dbReference type="DOI" id="10.1073/pnas.1106399108"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2018" name="ACS Catal." volume="8" first="1973" last="1989">
            <title>Structure of Aspergillus fumigatus cytosolic thiolase: trapped tetrahedral reaction intermediates and activation by monovalent cations.</title>
            <authorList>
                <person name="Marshall A.C."/>
                <person name="Bond C.S."/>
                <person name="Bruning J.B."/>
            </authorList>
            <dbReference type="DOI" id="10.1021/acscatal.7b02873"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2019" name="MBio" volume="10" first="0" last="0">
            <title>Mutations in hmg1, challenging the paradigm of clinical triazole resistance in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Rybak J.M."/>
                <person name="Ge W."/>
                <person name="Wiederhold N.P."/>
                <person name="Parker J.E."/>
                <person name="Kelly S.L."/>
                <person name="Rogers P.D."/>
                <person name="Fortwendel J.R."/>
            </authorList>
            <dbReference type="PubMed" id="30940706"/>
            <dbReference type="DOI" id="10.1128/mbio.00437-19"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2020" name="Appl. Environ. Microbiol." volume="86" first="0" last="0">
            <title>Characterization of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase as an antifungal target.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Wei W."/>
                <person name="Fan J."/>
                <person name="Jin C."/>
                <person name="Lu L."/>
                <person name="Fang W."/>
            </authorList>
            <dbReference type="PubMed" id="32005728"/>
            <dbReference type="DOI" id="10.1128/AEM.02986-19"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7 13">Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (Probable) (PubMed:32005728). In this module, the cytosolic acetyl-CoA acetyltransferase erg10B catalyzes the formation of acetoacetyl-CoA (PubMed:32005728). The hydroxymethylglutaryl-CoA synthases AFUA_8G07210 and AFUA_3G10660 then condense acetyl-CoA with acetoacetyl-CoA to form HMG-CoA (Probable). The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases hmg1 and hmg2 (PubMed:22106303, PubMed:30940706). Mevalonate is also a precursor for the extracellular siderophore triacetylfusarinine C (TAFC) (PubMed:22106303).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8">
            <text>2 acetyl-CoA = acetoacetyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21036"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:21037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activity is increased by monovalent cations such as K(+), Rb(+) or Cs(+).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="8">42 uM for acetoacetyl-CoA (in law salt conditions)</KM>
            <KM evidence="8">8 uM for acetoacetyl-CoA (in the presence of 100 mM NaCl)</KM>
            <KM evidence="8">8 uM for acetoacetyl-CoA (in the presence of 100 mM KCl)</KM>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
            <location evidence="14">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 7">Leads to lethality.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Even though it is not involved in catalysis directly, the Cl(-) anion stabilizes the catalytic site via both direct and water-mediated hydrogen bonds to catalytic residues and residues adjacent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="8"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA65"/>
    <dbReference type="SMR" id="B0YA65"/>
    <dbReference type="EnsemblFungi" id="EDP48908">
        <property type="protein sequence ID" value="EDP48908"/>
        <property type="gene ID" value="AFUB_083570"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083570"/>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="PhylomeDB" id="B0YA65"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Thiolase"/>
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    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
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    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
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    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0756">Sterol biosynthesis</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000454147" description="Acetyl-CoA acetyltransferase erg10B, cytosolic">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P24752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q4WCL5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17352532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22106303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="30940706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="32005728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source ref="5"/>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="17352532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="32005728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source ref="5"/>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="16110826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="32005728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="398" mass="40909" checksum="648C2196D8C00BC8" modified="2008-04-08" version="1">MSSLPAVYIVSSARTPVGSFLGSLSSLTAPQLGAHAIKAALAKVDGLKPSDVQEVFFGNVISANVGQNPARQCALGAGLEESTICTTVNKVCASGLKAIILGAQTIMTGNADVVVAGGTESMSNAPHYLPNLRTGAKYGHQSLVDGIMKDGLTDAGKQELMGLQAEECAQDHGFSREQQDEYAIRTYEKAQAAQKAGLFDEEIAPIQLPGFRGKPDVTVTQDEEPKNLNPEKLRAIKPAFIPGSGTVTAPNSSPLNDGAAAVVLVSEAKLKELNLKPVAKILGWGDAAQQPSKFTTAPALAIPKALKHAGVGQDAIDAFEINEAFSVVALANMKLLGIPEEKVNLHGGAVAIGHPIGASGARILTTLLGVLKAKKGKLGCAGICNGGGGASALVVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA93</accession>
    <name>B0YA93_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_083850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA93"/>
    <dbReference type="HOGENOM" id="CLU_043821_1_0_1"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="335" mass="37810" checksum="7FD028F061B82913" modified="2008-04-08" version="1">MNHPVAPADAKGSLPTWTGVQGSDEADHKLLKPTTRETARSRWGSDFTVDWVSGNGKGTILDERHNNQRTNFLMANDVRSLSDLELVKSRRQPGEDKWLRHLRSALSTVGTLATDITRRLDYTYYSLLEKVAALTSTFASFQELSDSASTIFDDIERETSVLDGDIRRQIADLKDFQPQMRKIERLEERMRSGKKKADALGKRLEAIRNRIDLWEEKEVEWQTRVGRRLRVFWVIVALSVLVFLVVLISQKSSAICIPLFESSVPVEMGDRRASALAIRLPEPASGEVWSRDDSCSETRPGCNRKSHSAPTPSSPTFNAMTTHVSSDPLRKIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAI5</accession>
    <name>B0YAI5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_084790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAI5"/>
    <dbReference type="ESTHER" id="aspfu-q4wbc5">
        <property type="family name" value="Bacterial_esterase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084790"/>
    <dbReference type="HOGENOM" id="CLU_038297_1_0_1"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="PhylomeDB" id="B0YAI5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="75"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="378" mass="41763" checksum="A23C35FD20262582" modified="2008-04-08" version="1">MKYFALSSTLMMANLYLLAIVFSLVAVAVETPHRRTYFYVGGNYTLNNDGEHIITNQMYVERLTPVDGPRRQYPIVFIHGADQTATNWLNKPDGDEGWASYSLSQGYECYLLDHTSRGRSPWDSRNGQLRKYSAEHLQKYFTDTAKYNLWPQASLHTQWPGTGVMGDPIFDSYYASTVPSLAENAAQEASMQPAGAALLDAIGKPVILVAHSQGGAMAWVTADRKPDLVHSIVSIEPSGPPFQNAIFGSGPARPYGLTDIPITYSPPATDPDADFVKQTITSNSSAISDCVIQADDPPPRQLANLSKIRTLVVTAEASYHATHDWCTARFLKQAGVPTKHLQLREVGIHGNGHMMFLEKNSDQVVRAIHNWIEDSTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAL3</accession>
    <name>B0YAL3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_085060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085060"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="PhylomeDB" id="B0YAL3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="250" mass="26025" checksum="AB03AAB0F77CFB8D" modified="2008-04-08" version="1">MVRKVVVVTGSASGMGLATATSLASSGAHLALWDINSSKLKEIAKSFKAQYSGKILAQTVDVSDRSAVKAALIEAQHHLGPINAIANFAGTGGHQLGVEPIWETSNEEFEFITNLNIRGLFNILGEALTPGFLGELQSIVHIASMFGTRGYKNGAVFAASKHAAVGMVKSAALEVGSRGIRVNCILPGPIDTPMFHQVRENAGLSSSASDTPIPRPGQPEEVASIAVFLLGDQSSYVTGAVWNVDGGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB94</accession>
    <name>B0YB94_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_092010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092010"/>
    <dbReference type="HOGENOM" id="CLU_1156141_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="240" mass="25914" checksum="9AEB539778B3CAF3" modified="2008-04-08" version="1">MNYVRINFHGKLISPRAGQLRNRNIRAREVNLTRLERIPLERQQSMIGHIVRNLHFLGHGIPTRNGGIARVQRRIIHTLTLWSLRCLEPIAGEPVIAPAGLTLDTVRTVPTLLPIDIRARQEAGFEAVLRGLLLRLSWQVRRVQQFVNDALVLTDAIAEHAAVVTVVVDAPLHFDLLAGGVGGDWFGAPVTARLVVVDAIAGIVPAGTAATDSGGVEVGPGRDGFQDGAFRTGVHAGLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBG1</accession>
    <name>B0YBG1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_092690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092690"/>
    <dbReference type="HOGENOM" id="CLU_2120564_0_0_1"/>
    <dbReference type="OrthoDB" id="4446818at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="114" mass="12896" checksum="E8027ECA1E83462A" modified="2008-04-08" version="1">MTWCQTDNQSAILKKHALRGLNQLVAAKLRSWKGAKKTFSKSSKSQELQAMHRLPSTSTIDLAVTNCATKLIKCHLYHENYGSDHRAAYSEWSLQPSNYNGKEGSGNFFYTVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBJ2</accession>
    <name>B0YBJ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_086790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086790"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="PhylomeDB" id="B0YBJ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF153">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="191"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="627" mass="68446" checksum="10C9E4F3AAB749BD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBP8</accession>
    <name>B0YBP8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_087400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087400"/>
    <dbReference type="HOGENOM" id="CLU_663882_0_0_1"/>
    <dbReference type="OrthoDB" id="5068061at2759"/>
    <dbReference type="PhylomeDB" id="B0YBP8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="414" mass="46866" checksum="2EE5A365797E75BA" modified="2008-04-08" version="1">MRRSIIKTPHYHSISSHAYPESTTQMCNMSTAIWNPDIILQISDPSGRGMLCVGLARPHSPSGLRGRCRCDVPSARYRQILSILDTMSRTPPQYVTNRELRSIARLGLCDWHTHQVDEVVANWEDILGCVESINGTYEGQREEMNQDLKELQEDVDECRRLLLVKEDCKDALSVLLRRHLNRNARLKKELVESQATCARLQKDLARAKDQVEKNRGLSAENSRLSNLLKRAGEEQERYKNQATNLIAECEKLRMQSAELQADVNSGKDKYKDLQDKEESATRELIAASTELHEARSVNQGLENDKKALQSEIDVLKREVIELNDNNTSISSQLASTAASLQTVTKELSAAHQTNTELRIRIDRLSTPIWYRLIQWIKHKVAGVMNLRNAGKEVSDEEEEMALAPTGSRRDAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBS7</accession>
    <name>B0YBS7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_087690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087690"/>
    <dbReference type="HOGENOM" id="CLU_2249495_0_0_1"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="PhylomeDB" id="B0YBS7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF33">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="104" mass="10910" checksum="52DA901AFAF2ADF5" modified="2008-04-08" version="1">MEGGCACGLIRYRLETQPLIVHCCHCTSCQRETGTAFALNAVIESSMVTLLPSSTPVVPANDPHAIGIRQRTEHRSLSSVPCSGLVALRWSGAVLSVCEGGDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBW5</accession>
    <name>B0YBW5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS peptide transporter Ptr2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_088060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088060"/>
    <dbReference type="HOGENOM" id="CLU_004790_4_1_1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="B0YBW5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17350">
        <property type="entry name" value="MFS_PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="578" mass="63779" checksum="FCEDCDC710B7E712" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCC5</accession>
    <name>B0YCC5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_089700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089700"/>
    <dbReference type="HOGENOM" id="CLU_016397_1_0_1"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="PhylomeDB" id="B0YCC5"/>
    <dbReference type="Proteomes" id="UP000001699">
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    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="69"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="372"/>
            <end position="440"/>
        </location>
    </feature>
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        <location>
            <begin position="513"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="638"/>
        </location>
    </feature>
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        <location>
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            <end position="540"/>
        </location>
    </feature>
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        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="675" mass="74605" checksum="A3B9523DA92BEF56" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCQ2</accession>
    <name>B0YCQ2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AFUB_091000</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
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            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial intermembrane space import and assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="21">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="208"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
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            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP48383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="297" mass="31948" checksum="FBB18050886981D5" modified="2008-04-08" version="1">MFRPATRILLRAPGVAARGPVSRRLISTAPPDAKSRSWKSTIVRLGLAAGAVYYYNTSSVFAEQPSLSFLSKQSTPDSSDETQLPTIDSIKPRIREERQAESKAVSQPDAQPTQHEALSASEAALKSPQELEDEAGQEAAFNPETGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSTEEPKGMDCIDKFKGMQECFRRYPDVYGAELEDDDEADAAAATAAGVSEPSEQPASPTVSAPTAEIDASSDSEGKEGRAKDVHAQVKSEVAEKAEQAESDDLVPKAWHDTEGTKAQQTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD08</accession>
    <name>B0YD08_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">AFUB_093860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093860"/>
    <dbReference type="HOGENOM" id="CLU_090154_0_0_1"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="PhylomeDB" id="B0YD08"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP47542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="228" mass="26319" checksum="DCBBF3DDBF22A0F7" modified="2008-04-08" version="1">MSEGGGRADALRNANKQILPLICAITSLLTCCLLSERKTYSVGGPAEKKHPTMKAYWYDNKPGDQREPHDSGRPVTVDYLASIGVQYYHFPSLESVNELAKERGYKNRDEIVVSPQAMGDVYEEKVKMFFNEHLHEDEEIRYIRDGEGYFDVRGQEDEWVRIKLAKDDLIILPAGIYHRFTTDDKNYVKAMRLFQEEPKWTPLNRGADVDENSHRQSYLRTIQNKTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDC5</accession>
    <name>B0YDC5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_095080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095080"/>
    <dbReference type="HOGENOM" id="CLU_2412836_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="92" mass="10321" checksum="E95ED719F5B58A53" modified="2008-04-08" version="1">MPSQPAYFQLDQFSIMPFDGFSFKLQLAAHRCLAVCRDKETAKHVITRYGLAAWGAVVSLWLPEAIIWAVFGEEGKLKSPSDRLLLGLSSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDX3</accession>
    <name>B0YDX3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_097110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097110"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="PhylomeDB" id="B0YDX3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF2">
        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="445" mass="47543" checksum="33774C613F01625B" modified="2008-04-08" version="1">MLVKIKSVVNTTAHEDGMSTKMGTAQDRKDMRRVGRQQELNRNFRFLSVLGFTAVLMCTWEAVLFGASNGLINGGKGGMIYTYLGGVAGFTFVILSMAEMASMAPTSGGQYHWVSEFAPPSCQCILSYITGWFCVLGWHTGIAGCCYTVANMMVGVVAINYPDTYVYKPWHVTLLVIAVALVALLFNTLLAQKLPLIEGIILVIHCFGFFGILIPLWVLSPRPTASEVFGPIQDRGGWGNNGLACLVGLVGSIYALIGPDSAVHMSEEIRDASRVLPLGMIWTLILNGSTGFVMIITLAFCVGDIDHVLESQTGFAFIQVFLNSTGSVRAATGMTVVIMAMQFCAAISNVATTSRQVYAFARDKGLPFSNFLSTVNPTFIVPLNALCMSLAIVSLLSLINIGSSVAFNAIMSLARQLSIPHTSSPSPAFACVDGAISLCLPPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE04</accession>
    <name>B0YE04_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_097390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097390"/>
    <dbReference type="HOGENOM" id="CLU_049343_4_1_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="PhylomeDB" id="B0YE04"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF38">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="40568" checksum="706F9407FA5008EE" modified="2008-04-08" version="1">MLCACPTYFRESESNSTFCKHVRRYSTEIKRQLPQECNAQKYHTSSQHSLEVRTFLVNMVGFDMCGLTPAPVTPFTQDGAVDYEAIQRLGSWLGSIDGVKGLVVLGHAGEGTFLTAEEQVSVIKAFVKSVDGKVPIIAGITGEGTEVAALEAKRAKEAGAAAGLLYPSHGWLRFGYQRGAPQHRYRRVYEVSGLPLILFQYPDNTKATYDLQTMLDIAAQPGCFAMKNGVRNMRRWDTEIPIIRAQRPDLQILSCHDEYLLHTAFDVDGFLVGYGNIAPEPLIELIKAGKAKDYKKAREIHDRLLPVTKSVYHRGSHMEGTVALKHGLVARGILEHATVRSPLLPLEPGAEQEIHAAINAASLSKVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE41</accession>
    <name>B0YE41_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT and Ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_097760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097760"/>
    <dbReference type="HOGENOM" id="CLU_1266614_0_0_1"/>
    <dbReference type="OrthoDB" id="4807664at2759"/>
    <dbReference type="PhylomeDB" id="B0YE41"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="218" mass="25001" checksum="03A5AD14CFA0AA8C" modified="2008-04-08" version="1">MQLVLTQDWTARKLAGRINERLYGWDLKECVESMMNMDWMHEEGYEQQRSDSGTIKIRISPESMAIINGELLRLKEFNEVRLDADIRDYLEDAHSSFKSKSTLNPRESKFKKSLVHYAAMGDCSELLRFLLANGVARDDRDQNSRTPLSWAAEYVALDSVRILLDDGAEINSMDDMLLTPLSWLVHAGVTTLKLAATEAYMRERGAMLNPEEDQNCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE56</accession>
    <name>B0YE56_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_097910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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                <person name="Amedeo P."/>
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                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Bussey H."/>
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                <person name="Dyer P.S."/>
                <person name="Egan A."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
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                <person name="Nierman W.C."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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</entry>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Galens K."/>
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                <person name="Inman J.M."/>
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</entry>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
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                <person name="Silva J.C."/>
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                <person name="Bussey H."/>
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                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
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            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </evidence>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101300"/>
    <dbReference type="HOGENOM" id="CLU_1019731_0_0_1"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760886" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31638" checksum="1FE2EFBE12D6A6F0" modified="2008-04-08" version="1">MRFLNLLLALSPLAQVSSAIPQEWGNSTGPLGGNLITDPARLSELHEVHNEVIRMLNTGETLPVERSRSLTVHGQHDKRVYQAFGLLGVFVASMFGLKTVEKITDQLLELFTSDDTIWTRKENCRAYFSTQGGGNEEFRTYARDHGNPTSEVHKNVGWIDPEHTAPPIHFFEGDQGDSAIGVYSVQYTATDRVAWSGIPDTEKCPFEGLCNPQYIFYHNGYQIVLNTWQSQGRISACQYSQGEDCLGLCSSGVKNQFSRGGVRWGGDCAIPCIDDAGDGYDVVPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YFB2</accession>
    <name>B0YFB2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_102760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499613">
        <property type="protein sequence ID" value="EDP47059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YFB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_102760"/>
    <dbReference type="HOGENOM" id="CLU_452119_0_0_1"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="PhylomeDB" id="B0YFB2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="67141" checksum="6AC5A4674D1C6FD9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMB3</accession>
    <name>B0XMB3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-oxo-L-prolinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_000420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000420"/>
    <dbReference type="HOGENOM" id="CLU_002157_0_0_1"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="PhylomeDB" id="B0XMB3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="235"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="545"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="742"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1281" mass="138627" checksum="11EF652DE6872C4B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMG2</accession>
    <name>B0XMG2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloalkanoic acid dehalogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_000140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000140"/>
    <dbReference type="HOGENOM" id="CLU_045011_3_2_1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="PhylomeDB" id="B0XMG2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="237" mass="27129" checksum="607A43270767A9C5" modified="2008-04-08" version="1">MSNLLDYRLLSFDVYGTLIDWESGVWNAFQPTLARNGNPPITKDQYLHVYHELEKQQQSQTPDMPYSRLLTTIHPLLTQRLGLNSPTSEESHIFGESVGHWPAFPDTVEALKRLRKHYKLVVLSNVDRESFAKTNAGSLQGFPFDLVITAQDVGSYKPNLENFRYMLKSIREAFGVEPEQVLQTAQSQFHDHHPAKMMGLKSVWIERPGATMGNLSETVYDWRFDTLGEMADAIEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNA5</accession>
    <name>B0XNA5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cut9 interacting protein Scn1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_004270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004270"/>
    <dbReference type="HOGENOM" id="CLU_031506_3_0_1"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="PhylomeDB" id="B0XNA5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="461" mass="52357" checksum="8C9AF463493DDE83" modified="2008-04-08" version="1">MLIQLIHEWSMLVTEAPGITVITVMVSVFPVSFRYYYITAFSCHPQGPKTISIILPRDQHIWDGRNMPEYDHDKVPDFPWELGVYDAHCHPTDAMSSISDIPGMKAATLTVMATRAEDQDLVFQIAKDLNNAKLTVQDAETDRVLPSFGWHPWFSHQIIDDQKSSSDITQGASDLESKKTHYHKVLTPAPEDEDFVSSLPDPKPLSQFISETRERLLSFPNALVGEVGLDRAFRLPKAWTQQEAENRNAHITPGSREGRKLSPYRVHMEHQKAILKAQLRLAGELRRPVSVHSVQAHGAVFDVFKELWSGHERRVPSRRERRRRLSVEGAHAESDAEDEQVQKSLKREGSPLPYPPRICMHSYSGPVEQLKQFLNPSNPSDVYFSFSNVINFSGPSSQKVIAVVKALPEDRVLIESDLHTAGQQMDDLLEEVARQICELRGWSLQEGVQRLADNWKRFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNL3</accession>
    <name>B0XNL3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_015560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNL3"/>
    <dbReference type="HOGENOM" id="CLU_007003_4_1_1"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="PhylomeDB" id="B0XNL3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="267"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="715" mass="79709" checksum="02C79DD1D17F1E7A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNN5</accession>
    <name>B0XNN5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_004910</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004910"/>
    <dbReference type="HOGENOM" id="CLU_013294_0_0_1"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="PhylomeDB" id="B0XNN5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="15">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP55795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="549" mass="62357" checksum="D5D994A96C79F34F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPH8</accession>
    <name>B0XPH8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_006530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006530"/>
    <dbReference type="HOGENOM" id="CLU_021152_3_1_1"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="PhylomeDB" id="B0XPH8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000066">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="110"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="445" mass="48109" checksum="EF33D52141D73BBD" modified="2008-04-08" version="1">MGLLRILWCHPKGARCGRTKRSSRKTTYIRTTQLLDSKSRHRQSTAIDLLKSSFFSLFAYIIVSFQLVNGPYDNAAAVDRNASDRVCSTIQGSWMVRASYFLSIQTLIECSRIFLKLELLQPSGSFKSRGIGNLIRSALLDPQNKDEQLHFYSSSGGNAGLAAVIAARDLGYPCTVVVPFSTKPMMINKLWAAGAADVIQHGASWSDADTYLRKNYIYNQDTQHSSRRNIYLCPYDHPEIWKGAATMVSEMVDQLPPRDPSSTCNFPADAIVCSVGGGGLFNGIVEGVDSYLQSQAMNGKGNARRNVKILAAETHGADSLALSLQHGSLQSLPGITSLATSLGAVCVAEKTFQYASSPPAGIDVASVVGSDAEAARGVLRLADDLRLQVELACGISVEVAVGGRLRNLIPDLTPNSRVVIVVCGGSNITAEMIAEYRHQLESGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPV2</accession>
    <name>B0XPV2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroxy-acid dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_007680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007680"/>
    <dbReference type="HOGENOM" id="CLU_014271_3_0_1"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="PhylomeDB" id="B0XPV2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="7">
        <location>
            <begin position="387"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="606" mass="64388" checksum="A5B16887C70E14D8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ17</accession>
    <name>B0XQ17_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF431 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_008370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ17"/>
    <dbReference type="HOGENOM" id="CLU_080487_0_0_1"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ17"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="208" mass="23152" checksum="94060D01B0951D4F" modified="2008-04-08" version="1">MSHQNNVPSARQLTFVVEHLDPELGPWSALEYGCIARESYAAGARFLLSSVPTSLQLPNDLAATQGLEVEHRSVEEIFADRKSKVCLLDPAAQVELSPEDGDIFDVFLFGGILDRTSELRKKGYVGRRLGPKQMTTDTAVRVTRIVAQGKVPLEKIEYVDDPEIIVNKHERIEMPFRYVKGDDGQPIMPAGMVDLIKKDADKAVDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ97</accession>
    <name>B0XQ97_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF636 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_009199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009199"/>
    <dbReference type="HOGENOM" id="CLU_2722882_0_0_1"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8407" checksum="0F586B2B702E8041" modified="2008-04-08" version="1">MLWLWDHHWPELIHPFASAIDTDLPAPDEMVCVLGNSKPSWVRWPEGKKSVHDVYGDDSIEGWHKKHGLFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQC8</accession>
    <name>B0XQC8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_009500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009500"/>
    <dbReference type="HOGENOM" id="CLU_075090_1_0_1"/>
    <dbReference type="OrthoDB" id="273230at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21630" checksum="A5C02C6C545D4BD6" modified="2008-04-08" version="1">MTSLRLNPSTLRLTPQLTKPLPSRILRASITSSLALRPLSAHPLRRSPLAPVPSFKRIPPSASPFSTGKSQADLLVEELQELYETAKDEFEIATDSTASSTIYAASDRESARDALNQLLAVYSLYTTDIAATAESHAPQELQQGDDAADERGQLVNTDFDPSEIPAPVRDEVRRRVGQRVRELSNAVEALEERAHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQE4</accession>
    <name>B0XQE4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_009660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EDP56258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="70" mass="8179" checksum="887F162665662EAC" modified="2008-04-08" version="1">MSITPEDRGQTSNNEPRWDDGEDLGREYEQPSSCKVVPYRQHPDGEEAALLRSNTERFQMFFRAHSAIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR20</accession>
    <name>B0XR20_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_011950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR20"/>
    <dbReference type="HOGENOM" id="CLU_023000_0_0_1"/>
    <dbReference type="OrthoDB" id="5226996at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="617"/>
        </location>
    </feature>
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            <end position="661"/>
        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="661" mass="74138" checksum="22E182BBBCD31DA0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRM6</accession>
    <name>B0XRM6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intracellular protein transport protein (UsoA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_013210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRM6"/>
    <dbReference type="HOGENOM" id="CLU_006318_4_0_1"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="PhylomeDB" id="B0XRM6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.130:FF:000001">
        <property type="entry name" value="Intracellular protein transport protein (UsoA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="341"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="7">
        <location>
            <begin position="935"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1040"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="679"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1046"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119187" checksum="0AA58FE0E28386E8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRZ8</accession>
    <name>B0XRZ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_025410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025410"/>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0XRZ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="517" mass="58716" checksum="EFC58BB4E384328D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS09</accession>
    <name>B0XS09_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNARE protein (Ufe1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_025520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025520"/>
    <dbReference type="HOGENOM" id="CLU_047847_0_0_1"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="PhylomeDB" id="B0XS09"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SNARE-complex protein Syntaxin-18 N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="385" mass="42836" checksum="33CFB745DA3BB917" modified="2008-04-08" version="1">MTDITSDFNKVLKDKNASTTIPTGEPRPPSTTTADEFLKEAYRINSHIHSLLLYLQSIRHSYLSTTPTVHPRTTSLRTSPTPSTPASTSTPSSKPLTDSERDSIDSSTALLLRDLSTSIANLSTAETLRQETESGLLRKKHRASSALLRWAAGASALANTPTENKSPEQIHDEERARTLRTVRESILWFLRRGLERAAEAQRDMVEKRIERVREKEKSVLYKSEAGGARPVPASVPVSGPGPATADPHLRGSTLSETETAAIEAELSPEQLQLFAEENDLLLRQYEDALSKVQYVTFYSSLTLWRRNAEKSLLEISSLQQTLVSHLSTQEEYIEQLVMDASTTTTNIGQGNKELKRATQRRSTAQAVFWGTVGLCTWLVVWDLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS63</accession>
    <name>B0XS63_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_026080</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026080"/>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="PhylomeDB" id="B0XS63"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000381">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000487">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000978">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001079">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="14">
        <location>
            <begin position="1241"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="1991"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="15">
        <location>
            <begin position="2352"/>
            <end position="2384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2384" mass="269583" checksum="D62AE34718F5E08D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS79</accession>
    <name>B0XS79_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_026240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026240"/>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="PhylomeDB" id="B0XS79"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP54565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="150" mass="15832" checksum="CA6114FD4EEE6F1D" modified="2008-04-08" version="1">MPPKKTTTAAKENVSLGPLAGDGKLVFGVARIFASFNDTFVHVTDLSGRETICRVTGGMKVKADRDESSPYAAMLAAQDVAARCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARSGMRIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSE7</accession>
    <name>B0XSE7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_026929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026929"/>
    <dbReference type="HOGENOM" id="CLU_089876_1_1_1"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="PhylomeDB" id="B0XSE7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000075">
        <property type="entry name" value="Thioesterase family protein, putaive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="170" mass="18843" checksum="066B3560888F2AF7" modified="2008-04-08" version="1">MSSSSIRRPSRRLEQFEELVYEYSARMGQHDQEHWDFDPRACNLRFESATRGPPAQVSYLLTVAPKLCNFMGNLHGGCAATIIDILSTAILLGVSKPGFFSLGGVSRNLKVTYLRPVPANTEIRLVCQVIHTGRRLALLRAEILRADNGDLCVLGEHEKANTDPESSGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSJ4</accession>
    <name>B0XSJ4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_027410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027410"/>
    <dbReference type="HOGENOM" id="CLU_1383848_0_0_1"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="PhylomeDB" id="B0XSJ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="2">
        <location>
            <begin position="72"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="197" mass="21626" checksum="68F0367D13BFD67C" modified="2008-04-08" version="1">MTIRSLGLQIIAHIYLEILRTKPQSPLHQCLVLSPTRNLHGRRQTILLFPALCGCWSQQRCEQVRLQEILIVLAWYHQHSLPVTPLNPRAPQIDLPSKSYQTVPSPGALPSPSQTSLSVVTPPAVTLPLLQEAHSVGIPAVWLQPGTFDDAVLEYAREHFEAAIAGDGGRGHEGWCVLVDGEEGLDAAGVQWTSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSR7</accession>
    <name>B0XSR7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_017350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017350"/>
    <dbReference type="HOGENOM" id="CLU_330120_0_0_1"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758305" evidence="1">
        <location>
            <begin position="20"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="2">
        <location>
            <begin position="80"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="3">
        <location>
            <begin position="210"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="830" mass="91795" checksum="F1AD8DB948036107" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT07</accession>
    <name>B0XT07_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_028450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028450"/>
    <dbReference type="HOGENOM" id="CLU_000022_38_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B0XT07"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="272"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="360" mass="39418" checksum="36F2CC517A9DB27A" modified="2008-04-08" version="1">MASRGAKNLILLSRSGATRDSAKELLRDLEDLGVRVATPRCDVSDRTSLRHALNECSAAGMPPVKGCIQGAMVLRDSTFANMTIEDYYTALKPKLDGSWNLHSELPKDLDFFILLSSISTIVGNRGQSNYNMGNSFQDALARYRVLNGLKATALDLGMVLSVGYVAENDSDLINHLRDVGVEPMREEEFLSILDELCNPNQPATIPLTKSQISLGLQMPETRVATGAEEPGWMRDPLFRHLYRIRTLEGAAESDERSVNYALLLAGADNFEEASGIVYEAMVSKLVKALNISQGDVDPSKPLHALGVDSLVAVELRTWMLKQLDADVAVFDLMEVASLRALASLIATRSGYVKKDNGKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT81</accession>
    <name>B0XT81_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HLH transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_018340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT81"/>
    <dbReference type="SMR" id="B0XT81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018340"/>
    <dbReference type="HOGENOM" id="CLU_008057_0_0_1"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="PhylomeDB" id="B0XT81"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000116">
        <property type="entry name" value="Putative HLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="165"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="866"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="988" mass="108254" checksum="E5E44920FB4F17F4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU67</accession>
    <name>B0XU67_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_030510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030510"/>
    <dbReference type="HOGENOM" id="CLU_1348662_0_0_1"/>
    <dbReference type="OrthoDB" id="4509376at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="218" mass="24180" checksum="C8ACD954F2F8AC38" modified="2008-04-08" version="1">MNEAIYCTITGRRSHCIAPSIDLFFLSLSCRNPPSKPHTTNPQNPVTQTPQEQRVQPHQRQRGDPVSSITRRTVDSKPSNDEELARLKQRREQEQKNLQAASDVDLEYGVEEQPAEGDIARAVRQKSERAQAGAHAGPVGSAQGPGHPGFGEERDLAADMERKREEHDRILGDRVDQSPDDPRGEAAEREALRQRKLKEEENLDVKGAVRAGTGDPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU70</accession>
    <name>B0XU70_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_030540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030540"/>
    <dbReference type="HOGENOM" id="CLU_023703_0_0_1"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="PhylomeDB" id="B0XU70"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000005">
        <property type="entry name" value="pH-response regulator protein palC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="509" mass="54737" checksum="41C776BB1E289D1C" modified="2008-04-08" version="1">MVYAFALPTTTHLSFQTFLSSSTHPSLPQAASTARHALRLALKAHKRLPHSPQRDSHLITILDALNGYLPYLAAISHGLSGRPVESGSSTGGEEIEVTLHSELETEWRATLSSTPLSLKSRPINGRVRGQGIDFEIAFVLTTLGYVLSGLARSGILRALYAPTTPTPEQRTAAVQTATKYLLQASSVHSLLASSPSFIGAARQTSTAAAVPDLDPAAQAALSSLALAEATLLAVLKDDSYVAACIQARNPNDKDWMVRAPEIPKVRALLFARLCVRAAEYAEQAAAGMGTVGAHGKTGIDEEVVGYARVLGRVARARACRFFGVDAELAGKIGEGIAWLRAAKGALGLRSASQGEKEASGKSKGGLSRLKKEWAERREERRLEKESGGKDRVAKGELDPGDDAGREEECRVIEMLETKWERMNDTINTQIIPPSTDLLANLPSGRDIHSPPGPYKLPSLDEEQLVRMRAPPAEDDYEPRMNMDDSDDELTSPAGVAPGALPERSDSTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUE5</accession>
    <name>B0XUE5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkaline serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_020450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020450"/>
    <dbReference type="HOGENOM" id="CLU_095071_3_1_1"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="PhylomeDB" id="B0XUE5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="127" mass="13438" checksum="0D72E2BA50DA8312" modified="2008-04-08" version="1">MTLGLPCGAVMNCCDNSGARNLYIISVKGVGARLNRLPAAGVGDMVMATVKKGKPELRKKVMPAVVVRQSKPWRRPDGIYLYFEDNAGVIVNAKGEMKGSAITGPVGKEAAELWPVSSLLFSNTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUM4</accession>
    <name>B0XUM4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_020550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020550"/>
    <dbReference type="HOGENOM" id="CLU_326237_0_0_1"/>
    <dbReference type="OrthoDB" id="3870679at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="870" mass="96772" checksum="2BB7373449AD8A1B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUN6</accession>
    <name>B0XUN6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_020710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020710"/>
    <dbReference type="HOGENOM" id="CLU_129452_2_0_1"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="PhylomeDB" id="B0XUN6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15317" checksum="C11AD5CDBF20AFD5" modified="2008-04-08" version="1">MTQSLPFYLYKLVPSTSPVREPLPERLPVSELDQESGFIHLSTALQVPNTLKYFFKDEPLVYVLRIESERVIDDIRWESPDAKICGPRPDEGLFPHLYNGLRLGKNEVESIAVWTNEAGWDKAISQAKPWLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV12</accession>
    <name>B0XV12_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_021280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021280"/>
    <dbReference type="HOGENOM" id="CLU_074601_0_0_1"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="PhylomeDB" id="B0XV12"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27644" checksum="1F11CC0EB2944A23" modified="2008-04-08" version="1">MASGTTIQPSRPSLTSNDSAVLQALFDAESSPSSAVAIDPSLSPFPEYLHISASDHESLKARELSIIRSLQSDDVSMDTITSAIRDLDALITEHPTYPSAYVNRAQALRLHIEKTAEASTDPEEAIFTPGNTESASRLFSDLGQAISLCTPRSPADPVSTVQARILADSHTHRGYLLLKAARLKKNANGNEMVGGPDKLRDMGPDQLEEMASRDFFFGGRYGNKVAQQLAVQTNPYAKMCGAIVKEALRKEVEGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV54</accession>
    <name>B0XV54_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_021700</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV54"/>
    <dbReference type="SMR" id="B0XV54"/>
    <dbReference type="HOGENOM" id="CLU_010104_1_1_1"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="PhylomeDB" id="B0XV54"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="196"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="354"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="584" mass="64447" checksum="A5A606A6A324C5A1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV86</accession>
    <name>B0XV86_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_032240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV86"/>
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    <dbReference type="HOGENOM" id="CLU_891309_0_0_1"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="PhylomeDB" id="B0XV86"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="312" mass="35677" checksum="E49CE544DA975F21" modified="2008-04-08" version="1">MDLIVDTASTPSKLTTPALLGLRKRVVPVEPHSETSIFAPPASVSSSTASTWDRSLREVYSISATAEVQDKFACANAPPHALQFRQWFESAAYQSYLTGSPQRDHLISLCRLNVHRAINENITMIGMTPEWMRSDDAVSIFNLQQPSFALERIPPSLRPTPIQLQVPHHPWLDFFPFPRMRDLLILAGDAFDDDELCHDLMAFWDTRNSAATLLVWGDSWDPKNWEVTEKFAHKWTWMIRDSPELLASTNFWRRSRGEKPLDWKPPPVSKRPCRREPNGSNLRLTNAKLQFSKPTYTCHIVHFIHETTTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVG8</accession>
    <name>B0XVG8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI-anchored cell wall organization protein Ecm33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_022200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022200"/>
    <dbReference type="HOGENOM" id="CLU_1170428_0_0_1"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25995" checksum="0A7AE27978A6245A" modified="2008-04-08" version="1">MSRPQPPGHLLLPRLFLSSPHLNLMLNDDIFPSLLSLSTDSFCITIRDPSLQNSPAAFQFASSDDLNWFSTHNCTTIDDDITLLESFNGSFSLPNVTSIRGIITYTGPTETFKLTSISLPDVLYLGGMNVDLPDSQKIINVSAPKVTAIDSINLASVPAMSSRHRTNQLSVRLDSLEQVNGNLSIRGFDTIATNFLDDEAYGQLPLSFPALKYATFIQFSGVITECVISICIYISRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVN8</accession>
    <name>B0XVN8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase 2-nitropropane dioxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_033100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033100"/>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="PhylomeDB" id="B0XVN8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="359" mass="38192" checksum="5CAD084305E3A0A0" modified="2008-04-08" version="1">MSPLITTISRSYPWMKTPLIVSAPMRVTSGPTLAVAVSRAGGLGFIGPGVKTQDISSDLQTASSLIESLSASQSQPSALQNQPILPVGIGFQLWSDDLEVAISTISKYKPCAAWLFAPRHGQKDLDTWSRRIRHASPSTRIWIQIGTLAEARELAQGSEEPDVIVVQGAEAGGHGRANDGLGVMALLPEMMDCLPAHIPVFAAGGIADGRGAAAALCLGATGVVMGTRFLAATEARISPGYQREIVRASNGAVSTTRTLLYNRLRGTVGWPEEYSPRTIINKSFIEHQAGRPFEELKALHDEALKAGDAGWGPEGRLATYAGAAIGLIHDVKDAETIVRDVQEEVLQRLSNVQKANSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVQ9</accession>
    <name>B0XVQ9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell wall mannoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_033320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Constitutive protein of the cell wall. Antigen target of host humoral immune response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cell wall mannoprotein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVQ9"/>
    <dbReference type="SMR" id="B0XVQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033320"/>
    <dbReference type="HOGENOM" id="CLU_099165_1_1_1"/>
    <dbReference type="OrthoDB" id="3485059at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.140:FF:000001">
        <property type="entry name" value="Cell wall serine-threonine-rich galactomannoprotein Mp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="194" mass="19953" checksum="362E8892AAF18FCD" modified="2008-04-08" version="1">MPNIKSLHKLTDKQTDSKMHFKLSTAVLATLVGVALSGPLVARDAATILSDLSTIKTDINTLTQHFNEFTGDLLQALAAQAVEQQLESDIDQATADAKATSALSAADSTSVTNALLGLKPDIVTSLDAIVAKKPQVDSAGVGSLVLSDLNALQSKTDALSGALQDIATATDKDTIASGTQDIDAAFSSAIAVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVT6</accession>
    <name>B0XVT6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_022710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022710"/>
    <dbReference type="HOGENOM" id="CLU_042180_0_0_1"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="4">
        <location>
            <begin position="383"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="548" mass="60515" checksum="FAF9E34B0E930A19" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVY4</accession>
    <name>B0XVY4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_023230</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023230"/>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="PhylomeDB" id="B0XVY4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122519" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="342"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP54267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="517" mass="56187" checksum="E8DD14102E033835" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW28</accession>
    <name>B0XW28_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligosaccharyl transferase subunit (Gamma), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_023360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023360"/>
    <dbReference type="HOGENOM" id="CLU_052855_1_1_1"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="PhylomeDB" id="B0XW28"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000302">
        <property type="entry name" value="Oligosaccharyl transferase subunit (Gamma), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757959" evidence="10">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="325" mass="35939" checksum="DC8DACB8DD998447" modified="2008-04-08" version="1">MKLNSLISFLCIAASALCTSSDPNKYEKYKSVSPVAPIGLTDVTYHDLTSKPRDFHVAVLLTATDARYGCALCREFQSEWDLIARSWNKGSKSDDLKLLLATLDFSNGKETFQKLMLQTAPVLLLFPPTVGPFAKVDNAPVRFDFTGPLSADQLYTWISRHLPEGAKPPLIRPINYMRIISAITLLMGVITLFTVLSPYALPIIRNRNLWAGFSLIAILLFTSGHMFNHIRKVPYVVGDGKGGISYFAGGFSNQFGMETQIVAAIYAVLSFAAIALSMKVPRMGDKKAQQLAVVIWAGVLLCMYSFLLNVFKTKNGGYPFYLPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW45</accession>
    <name>B0XW45_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_023530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023530"/>
    <dbReference type="HOGENOM" id="CLU_004835_4_0_1"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="PhylomeDB" id="B0XW45"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000049">
        <property type="entry name" value="C6 finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="633" mass="70701" checksum="E66331BEA4E8A6E9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW86</accession>
    <name>B0XW86_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_023940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW86"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023940"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="PhylomeDB" id="B0XW86"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000107">
        <property type="entry name" value="Benzoate 4-monooxygenase cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="525" mass="60025" checksum="2B90DDD343EB5E9C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXB7</accession>
    <name>B0XXB7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_037500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037500"/>
    <dbReference type="HOGENOM" id="CLU_036923_1_0_1"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="PhylomeDB" id="B0XXB7"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904408">
        <property type="term" value="F:melatonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP52584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="360" mass="39791" checksum="A021F253B55BBA02" modified="2008-04-08" version="1">MGILDKLSRKSGVIVGDDVLRLFEYAQEKNFAIPAVNVTSSSTVVACLEAARDQNCPIILQVSQGGAAYFAGKGVSNDGQKASIAGSIAAAHYIRSIAPSYGIPVVLHTDHCAKKLLPWLDGMLDEDERYFKQHGEPLFSSHMIDLSEEPVDYNIETTAKYLKRAAPMKQWLEMEIGITGGEEDGVNNEDVDNNSLYTQPEDILAIYNALAPISPYFSIAAGFGNVHGVYKPGNVRLHPELLSKHQAYVKEKIGSNKDKPVYFVFHGGSGSTKEEYKQAISYGVVKVNLDTDMQYAYMSGVRDYILNKKDYLMSAVGNPDGEDKPNKKYFDPRVWVREGEKTMSKRVQVALEDFNTAGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXY1</accession>
    <name>B0XXY1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA helicase HEL117</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_038960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038960"/>
    <dbReference type="HOGENOM" id="CLU_053559_0_0_1"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="PhylomeDB" id="B0XXY1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="43406" checksum="706F776EB40FED8E" modified="2008-04-08" version="1">MSTRDYRHRERSHRDHDSRSRSRSPDRSGRHKRHHHHRRRHSHHRHRDYSHDRDRHSQSASSAPAVLPFKARELSKRDLTYYAPMFAMYLDIQKGLIMEDLSEEEIKGRWKSFIRKWNRGELPEGWYDPNTLEKARRNATEQPPVSGTGRRRDSPDYEQDDHGKDADTGAASEAPPRQNEREFNSEDEEEYGPILPHHEVTAKGRGGPFAGPAIPTIQDLELRKESALEDAIAARQDARKQHRAEARLHKSEMRQIEDEIAPRAEPGTRERRMEKRREAALANRAFAESRRGGSPIEAAPDDELMGSGENDLDAIKKAQAREQRKKNEREIRREEILRARAAEREERLQQYRKKEEETIGWLKTLAKQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY70</accession>
    <name>B0XY70_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_039850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039850"/>
    <dbReference type="HOGENOM" id="CLU_1635006_0_0_1"/>
    <dbReference type="OrthoDB" id="5426836at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760707" evidence="1">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="162" mass="17570" checksum="D13F53B35637584D" modified="2008-04-08" version="1">MSQIVRLLVSQPLHWLLALAATASASSSIDYTQYVNALMGLERPFSCKGYGGGDIFVGGARPFGMVKLGTDTTAANRSIAVLNGGWTPGGNVTAINAVEQWNKEVLSKTQVPLDRTANMAHVRLLYSSLYFMYPMPSNRTGDNPLWRKVSEWVSGVADTLES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYK8</accession>
    <name>DAPB_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable dipeptidyl-aminopeptidase B</fullName>
            <shortName>DPAP B</shortName>
            <ecNumber>3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dapB</name>
        <name type="ORF">AFUB_041260</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Lysosome-like vacuoles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYK8"/>
    <dbReference type="SMR" id="B0XYK8"/>
    <dbReference type="ESTHER" id="aspfu-q4wx13">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.006"/>
    <dbReference type="GlyCosmos" id="B0XYK8">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP52954">
        <property type="protein sequence ID" value="EDP52954"/>
        <property type="gene ID" value="AFUB_041260"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041260"/>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="PhylomeDB" id="B0XYK8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000412133" description="Probable dipeptidyl-aminopeptidase B">
        <location>
            <begin position="1"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="2">
        <location>
            <begin position="114"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="834"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="867"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="919" mass="103089" checksum="FF38600F2230B801" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYR7</accession>
    <name>B0XYR7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_041840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041840"/>
    <dbReference type="HOGENOM" id="CLU_022549_3_1_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="PhylomeDB" id="B0XYR7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="179"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP53013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="443" mass="50972" checksum="57809A1C7BE87163" modified="2008-04-08" version="1">MLIPLRYRRRITLISAVLGLFLIYHFISIRPNLPRPLSTVRSNLQQQRQQPKQKPDIHSDCPLLPGIEDVLVIMKTGVTEALDKVPVHFETTLRCIPNYVIFSDFEEEIAGVRIHDALRNMDPEVKRTVPDFDLYNRLQKLGRKGLGTQDFADEANSAIGKPNNPGWKLDKWKFLPMVQETLRHKNDAKWYVFMEADTYFAWPTLLEWLSNYDPQKPLYIGTETQIADVIFAHGGSGFIISRPALQLAADEYAARRVELDMFTDEHWAGDCVLGKVLLDAGVPLTYSWPILQNSNIRELDPFTAGFYRQPWCFPTVAFHHLSSQDIRNLWEFEQRRWKSHKRLLLHSDVFKELIYPELSNVRDGWDNLSGDEHVSVNTFQECQSICLNDSTCVQFALRAGSCFTSKTPRLGVESTAVRSGWVMKRIERMMESAPSCPKPDFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZU4</accession>
    <name>B0XZU4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pentafunctional AROM polypeptide, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_034400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034400"/>
    <dbReference type="HOGENOM" id="CLU_008871_0_1_1"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="PhylomeDB" id="B0XZU4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000463">
        <property type="entry name" value="Pentafunctional AROM polypeptide, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001167">
        <property type="entry name" value="Pentafunctional AROM polypeptide, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="4">
        <location>
            <begin position="527"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="3">
        <location>
            <begin position="649"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="5">
        <location>
            <begin position="787"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="828" mass="92348" checksum="63073FCC1192FCE2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y078</accession>
    <name>B0Y078_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_035060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y078"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035060"/>
    <dbReference type="HOGENOM" id="CLU_2739563_0_0_1"/>
    <dbReference type="OrthoDB" id="4384751at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="71" mass="7991" checksum="DFD1414B9A3F4FEB" modified="2008-04-08" version="1">MASTTSSITINVNSHCETPSPRFNHPRPIQLYRMQGYAVRMVPLDTDGLENADEYVMQLVVSIISLSMICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0D8</accession>
    <name>B0Y0D8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_045830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0D8"/>
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    </dbReference>
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        <property type="entry name" value="AMIDASE FAMILY PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Amidase signature (AS) enzymes"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="692" mass="75464" checksum="567CF9AEC5BA8CE3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1N3</accession>
    <name>B0Y1N3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_049910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EDP50989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36495" checksum="F303D80592A96BCF" modified="2008-04-08" version="1">MFISQSWALDINSRFRVEQGQGPVTRSGSGTYGGTCYGTDADLSAIYTEAIDLAQVALDSLNSYATSATVRATVETFFGIKADSSSPTTVSAIDSAQFAYVKWLTYLLLDIFGQIIAFSTGTEDAKISQPGFFCDDSWRWRTEMDYGSDGQMNGRTISQVTGFTTISDTQKVYTITMCPYSFTRAKRKDSLSAWRSKEKIIADGTPLRAALSTPGTLMHELAHLVTKQVVTDETLPNGQKAYFPPNVATLAAESKAKAVKNADTYTWFAIAMYLDQCDWSRQICAQSTSTSTVAKRSNNQTSTDMALMRRSNRRTFLPRVLTGLKGDSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y201</accession>
    <name>B0Y201_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock transcription factor Hsf1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_050430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP51041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050430"/>
    <dbReference type="HOGENOM" id="CLU_013966_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="B0Y201"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="146"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="799" mass="86796" checksum="A83AD71B722518C2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y239</accession>
    <name>B0Y239_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_061150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y239"/>
    <dbReference type="SMR" id="B0Y239"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061150"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_0_1"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="PhylomeDB" id="B0Y239"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP52081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="256" mass="28068" checksum="851F6F48825E134C" modified="2008-04-08" version="1">MPRQFFVGGNFKMNGVTDTITSIVKNLNEAKLDPSVEVVISPSALYLLLARQAADPKIGVAAQNVFDKPNGAFTGEISVEQLKDAKIDWVIIGHSERRVILKETDEFIARKTKAAIDGGLNVILCIGETLEEREAGKTIDVVRRQLTAVAKDLSKEQWQKVVIAYEPVWAIGTGKVATTEQAQEVHAAIRKWLSDDVSAEASENVRIIYGGSVSEKNCRDLAKQPDVDGFLVGGASLKPACKDFSLFECRSYRLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2C4</accession>
    <name>B0Y2C4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP dependent DNA ligase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_050960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2C4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050960"/>
    <dbReference type="HOGENOM" id="CLU_004299_1_0_1"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2C4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08039">
        <property type="entry name" value="Adenylation_DNA_ligase_Fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="353"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="912" mass="102531" checksum="89A42D01999C0BC7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2H3</accession>
    <name>B0Y2H3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Toxin biosynthesis ketoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_061810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2H3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061810"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2H3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="247" mass="26555" checksum="3F73559D4D5B06D9" modified="2008-04-08" version="1">MNRVVLITGVNRGIGRGLAAHYLAQPGTTVIGTVRDNSSEKAKDLSKLPKGRGCDLIIVPLSVDNPSRVAEAASEIQTRHHIEHIDVVIANAGICNHWGPIQEMTDLDVLSHFAVNTLGPLRLFTAMAPLLQRASTPKFVYISTLLASIHAIEQMPSLTAAYGMSKVAGNYLVKKIDAENKHSITLSIDPGLVQTDMGSRAAQLNGLEKAPVTVEDTVPGITRQIEAASKSTTSGQFVNYNGDWVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2P1</accession>
    <name>B0Y2P1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_051450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2P1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051450"/>
    <dbReference type="HOGENOM" id="CLU_019134_3_1_1"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2P1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000284">
        <property type="entry name" value="Lysophospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="9">
        <location>
            <begin position="262"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="560" mass="61082" checksum="6FF0DA9957F57E5C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y371</accession>
    <name>B0Y371_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell cycle control protein Cwf14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_053160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y371"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053160"/>
    <dbReference type="HOGENOM" id="CLU_087132_1_1_1"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="PhylomeDB" id="B0Y371"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="148" mass="17315" checksum="81150F3F1EF28025" modified="2008-04-08" version="1">MPPIRTSRNRKPPPAGFDDIEDTLLEFSNKMKDAENAPHDGKKKHEMLWPIFQISHQRSRYIYDLYYEKEAISRQLYEWLLKNNYADANLIAKWKKQGYEKLCCLRCIQTKETNFNATCICRVPKAQLKEDQMIQCVSCGCRGCASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y379</accession>
    <name>B0Y379_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_053240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="214" mass="24572" checksum="83FD89AD329639B1" modified="2008-04-08" version="1">MRTCSTFFGSLRRELIARQLPLVYDYLHPQPSHLLNLTLVDIIPHLQQTGHKHTILPSIKRPPPLKPGHHLVYFPPQVTLSQILPDGTDTLHFPGPPFIRRLWAGGRVRFPLMHSPLLDGSRAVCIETIRDVIVKGHQGEEKVLVDIERRIGAVMEDEEEESIRGRLWSDDANENMESSVIENRSLVFMRQKTTQQIEADKGEFDKVRRRIQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3C9</accession>
    <name>B0Y3C9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_053760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053760"/>
    <dbReference type="HOGENOM" id="CLU_005912_5_2_1"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3C9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="51"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="700" mass="76621" checksum="D73D89413E8B1E0C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3F5</accession>
    <name>B0Y3F5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_054020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3F5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054020"/>
    <dbReference type="HOGENOM" id="CLU_000288_172_1_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3F5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="646" mass="71811" checksum="0800AE77A7DE20E0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3I4</accession>
    <name>B0Y3I4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_054310</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054310"/>
    <dbReference type="HOGENOM" id="CLU_001222_2_0_1"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3I4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000379">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000821">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000822">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000074">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="48"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="225"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="581"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1441"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="794"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="587"/>
            <end position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP51425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1592" mass="179751" checksum="75EF18F438868A6F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3V0</accession>
    <name>B0Y3V0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_055510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3V0"/>
    <dbReference type="HOGENOM" id="CLU_035142_2_0_1"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3V0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF5">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="123"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="544" mass="61693" checksum="C4C7BE7DE4FE147D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y445</accession>
    <name>B0Y445_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_056470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y445"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056470"/>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_1"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="PhylomeDB" id="B0Y445"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="75"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="331"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="578" mass="61775" checksum="ED9A5B1951C8FD34" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y483</accession>
    <name>B0Y483_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bax Inhibitor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_056850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y483"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056850"/>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="PhylomeDB" id="B0Y483"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="281" mass="31771" checksum="51A58EE432274403" modified="2008-04-08" version="1">MAANARYEPAPQRDSFEDQPYPQAPPSYQATASTDAPRSEDDNVPDDFKFGGTVAEGTLPIRMQFIRKVYAILTIQLLLTTIMSSISFFSESYRLWIQSNFWLMMVSVFGALGFMLVTYWKRKSYPANLLFLSAFTLLEAYSISVVTSFYDARIVIQALILALGIFVALTLFACQTKYDFTNWMPYLFGALWFLILFGFMSAFFPYNSTAELIYGGLAALIFSAYILVDTQLVMRHYHVEEEIAAAISLYLDILNLFLAILRILNNQNNHTIGGLICNVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y494</accession>
    <name>B0Y494_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clock controled protein (Ccg-8), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_056960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y494"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056960"/>
    <dbReference type="HOGENOM" id="CLU_015714_2_0_1"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="PhylomeDB" id="B0Y494"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="510" mass="55001" checksum="1D89041F6CF3B555" modified="2008-04-08" version="1">MEARLVSSGRDAATTTTTSQTPSSHSSSSASSPLSAPATAFSSLQHVPSSMMDVDNHSVADERSRRATSVLSMDDIEAAQALEGLRAGNISPPLGCQWQADKIIDCVADYGHSSPRTSTQNNPSNVPSDSKPQPEPLLSLLTSTHPLISSAINGSMSAYTSSKSYSPRFKSGAEFIERNIGSPVANTVGTVGRKTGVESGLRWALQRRESNSSDPANKRRKVSGEKQQPQDVDVEKGLAGDNDAMDSQRTRSSSDLSHSEPLPPYDDNKSPNYEEIGRPSSRQSPATWQSRLMISTSGLGVAMSEESLRSLQYCLTWLRWANGRLGKAIIALQGALKEWDSAKRENGEGDASLLSQRIQAVKEDVLSTLKQVVDVVSKYAGGALPENARNLVRRHLTSLPHRFQVASTSKPPPDSSASSSDATLGAHRILVLAQEGLDMMAQVSGVVNDTLVSAELWCQRLGKKRPERDSKQPDGMQPPDSHREQYPVDVKQPIREGSQDVTMGGTEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4G7</accession>
    <name>B0Y4G7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_069030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4G7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069030"/>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4G7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="105"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="376"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="715" mass="81933" checksum="3413518D3A42F6DB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4I0</accession>
    <name>B0Y4I0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor Prf, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_069160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4I0"/>
    <dbReference type="HOGENOM" id="CLU_011017_0_2_1"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4I0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="847" mass="93670" checksum="EE278A5C3851976E" modified="2008-04-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5D1</accession>
    <name>B0Y5D1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">AFUB_062980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP49966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062980"/>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5D1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="256" mass="28497" checksum="2B737D9FD10220A7" modified="2008-04-08" version="1">MGAKILPMEATIPDKPSSPNLVAAFDVSEHLVPVRELKPAGNTLVSFDGLLEEPLILKEDLKEGCGGQLWPAGIVLAKYLLRQHRNNLSNKTIVELGAGGGLVGLAVARGCDVGPCPIYITDQEPMLHLMKTNIELNNLSTAVAATVLNWGERLPDCIPTHPEIVLAADCVYFEPAFPLLISTLQDLLGPESVCYFCFKRRRRADLRFMKAAKRVFDIKEVRDDPEADTYRRENIFLYSLRLRFRPENGSLRAIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6W9</accession>
    <name>B0Y6W9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_068410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6W9"/>
    <dbReference type="HOGENOM" id="CLU_2412834_0_0_1"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="92" mass="10000" checksum="7AFEAB4C90673841" modified="2008-04-08" version="1">MQQALELSQEDGRRSGNVDLSTIHLEELPAYTGPQGDMAGVHSHGQGLSPDPYSRQDGAGTETEPLDPPPGYEEVQQQSVANELEERLRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6X4</accession>
    <name>B0Y6X4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_068460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6X4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068460"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_0_1"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6X4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="370"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="503"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="543"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="704"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="879" mass="97824" checksum="9E2EBC2CF695B7DE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7A8</accession>
    <name>B0Y7A8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sreptomyces cyclase/dehydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_073160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073160"/>
    <dbReference type="HOGENOM" id="CLU_079653_1_0_1"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7A8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000048">
        <property type="entry name" value="Sreptomyces cyclase/dehydrase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="86"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="246" mass="27233" checksum="7CE71E7290CD4E8F" modified="2008-04-08" version="1">MKPSLPLRRICRGTNITIRPPTSPALVPRILHEQRTPPAPSTRSTPLTATTRRSFNLSSLSSFFPPSNGNGNDNNKSRVLTATRTLPYQPSALFKVISSVESYSQFLPFLTASTVTHRDPETGYPTRAFLTVGYGPLSETFTSRVDCNRDKWTVEARSGAKFGVDSKDGQEGGIFPGANEGIFEYLSTKWELVPVPGGSVQTRVQLEIQFEFRNQFHAAMMSAVEGQMAGVMIEAFEKRIREVEGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7U1</accession>
    <name>FAEB2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable feruloyl esterase B-2</fullName>
            <ecNumber evidence="3">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ferulic acid esterase B-2</fullName>
            <shortName>FAEB-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">faeB-2</name>
        <name type="ORF">AFUB_074990</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="3"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7U1"/>
    <dbReference type="SMR" id="B0Y7U1"/>
    <dbReference type="ESTHER" id="aspfu-q4wmr0">
        <property type="family name" value="Tannase"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="B0Y7U1">
        <property type="glycosylation" value="5 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP49472">
        <property type="protein sequence ID" value="EDP49472"/>
        <property type="gene ID" value="AFUB_074990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074990"/>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7U1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394927" description="Probable feruloyl esterase B-2">
        <location>
            <begin position="19"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="186"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q2UP89"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q8WZI8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="526" mass="57852" checksum="740A0F5765FC0713" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7Z2</accession>
    <name>B0Y7Z2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GYF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_075530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7Z2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075530"/>
    <dbReference type="HOGENOM" id="CLU_003433_3_0_1"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7Z2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="61"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="453" mass="50465" checksum="86252F3F02007C49" modified="2008-04-08" version="1">MKGATPFGHSMRPHFLIDPNFVNLNHGSFGTYPTAVREALRGFQDAAEARPDPFIRYTTPKALDASREAIAKMLNVPRHECVFVKNATTGVNTILQNIPFQSGDVIIYFETIYGALEKGIIALMESTPLQARKVQYQCPISHGDLVEQFLEVVRNTRAEGLNVKIALFDVVSSLPAMRFPFERLTDVCREEGILSLIDGAHGIGQIPLDLGRLQPDFFTSNCHKWLFVPRSCCVLYVPERHQHLIRTTIPTSWGYIPSPDAPETTPSIMKSDDPSKTPFESLFEFVATNDDAPYFCVPAALKFRNEICGGEERIYTYLETLANEAADLLAAVLGTEVLQEPNRKSGVPSQLRRCGMSTVQLPIAIQGRPGPIKPSYLVLQADKVASTINWFQTTLAHKYGTFVPVFAHGNCLWTRLSAQVYLEISDFAWLAGVLKEMCGELRSKQGGVDQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y814</accession>
    <name>B0Y814_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_075750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y814"/>
    <dbReference type="SMR" id="B0Y814"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075750"/>
    <dbReference type="HOGENOM" id="CLU_030506_0_0_1"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="PhylomeDB" id="B0Y814"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000023">
        <property type="entry name" value="Gliotoxin biosynthesis protein GliK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="273" mass="30501" checksum="61A9C0A798094BA1" modified="2008-04-08" version="1">MGKAALQDPHGGIWYFAYGSNLRLSVLENRGIKALDIKAVIVPSHYLTFDIFGIPYAEPSFASVAPFAREKKTTLRLGDSPASRDVPPVQGLAYLLNPRDYRQLVISEGGGVAYDEVEVHASILDKDGKPDPGATLIARTLQAKYPWRPNGAPSARYLGLISTGCKQNEPLTAYSDYIDSLPAYEPPTSLHAKVGGLLFLMFWRPPLRLLIRLIRVNTDQDGHCPQWLGWIILTLYGLMWSYHDNIHSKIWGRGDGRKLHFEETPAKEVPVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y898</accession>
    <name>B0Y898_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA splicing endonuclease subunit (Sen54), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_076590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y898"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076590"/>
    <dbReference type="HOGENOM" id="CLU_028449_2_0_1"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="PhylomeDB" id="B0Y898"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="76"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="50860" checksum="F26BD32012E8EA9C" modified="2008-04-08" version="1">MADMDEDIARLPSNGTSTHIETDLSDETQDFRMLNHLSFLADPSQSSLPKRGEKDFEPNPTEFQADVLAASRRAMHNALSYPRLHHPKHRIVGVYAPDGPAAPSIAPVTEGETQNTELKSGKARGTKLGVHQDACVYVANPKGQFFKTMGQGDRWNRVWLLPEEALYMLERGSLEIRWPVSATGCGDAGNAGDSGIPMSLQAAYACFIGRGGLTIDRFTVYTGLKRLGYTLTRAPAWYDDTEESSVGSETQEPVRVGAGLVGVYEQFMKWLQTPSPRTATLPLVGIGIHRSYSEFVPEAMIYKPANIPGDIYRKLSIIPWHDPTLPQSKAPRTEAPFRVVFHVYKPSTPFRKSAPPAPDFRIAVIDSRTHSMPTLSQLGALLESTPLDPPQGEKMDRQLYMRLRQGYRNVILAVIDQGVVSYLRVADAAFGKEKLYENRGTTQGNKVGGFSKSKKKPKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8C2</accession>
    <name>B0Y8C2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS amine transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_076830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8C2"/>
    <dbReference type="HOGENOM" id="CLU_001265_51_4_1"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8C2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="429" mass="45805" checksum="FC6984B4956CEADC" modified="2008-04-08" version="1">MDLDLTSIVRRCTFGSIPRWPLLIGLVALGASTALLCVGTTLGLWIAGRLFQGVAAAVVWTVGLALLVDTIEKEALGEAMGYAAMGITLGTLTGPLLGGVLYENGGYYAVFGLAFGIIGLDIFLRLVLIEKKDALKWLHIGKLSTEPVDNPTQKQPTDGRVSLSGTTDERDSNGRKEHVATSSSTPRGDTIGDANQQMPRKRRFGAVATLLASDRMLVTLWAYFIVAVALTSLDSVLPLFVQDTFGWKQTAQGLIFIPVSVPHVLDPFFGYINDKFPQARRFVVGGALLITIPLFVLLRLVTMNSMSQKVVLCVLLALIGLCLAFLIPPLFVEASYVVQEKEAESPGVFGKGGAMALAYGILNSAFAAGSMVGPFLAGFIRESAGWSTMSWVIGLLMGVSAIPILLFLGGPIWKPMERHAESQSAEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8I1</accession>
    <name>B0Y8I1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Meiotic recombination protein Mre11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AFUB_077420</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8I1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077420"/>
    <dbReference type="HOGENOM" id="CLU_009535_1_1_1"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8I1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010791">
        <property type="term" value="P:DNA double-strand break processing involved in repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010780">
        <property type="term" value="P:meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.110:FF:000003">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="21">
        <location>
            <begin position="290"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="525"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="699"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP49712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="784" mass="88102" checksum="56CE50290402A82F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8M4</accession>
    <name>B0Y8M4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_077870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8M4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077870"/>
    <dbReference type="HOGENOM" id="CLU_013452_2_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41968" checksum="E73EB707B3CE1571" modified="2008-04-08" version="1">MGPQRSKRAGRPRLDASRNAILSADRRSQVRRAQRTYRLKKEAAFRDATARAEQLQARMRTVIEEMTRLSEVAAEAQLHLSHPDIYASLERLQRIVADAYSPIEAGAPVEPSPDSSGQVQLISAQVQAPRQYPPTPPLPTRQHTYAFQEVRFARRLQRYCLEHAFRLYVDFRSDPREIHRVFRLVPCVRDRGKTQPRFRQLLMGGRADPLEVPSLPFYTVGGAGTHFPDVDEEGNAIYPANSRMPRRVLGVLPWPELGTKGGEEALEAYGLGGEWFDSRDVEGYLKLHGVDVNGGLFPTLHVAGGAAETDRSRSFVLDVEGFFSRKSRPPYCAIVPVLIAPGLLSGLVILGRAPGFRKTDVRRAFKASVKTVDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Q0</accession>
    <name>B0Y9Q0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_081850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9Q0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081850"/>
    <dbReference type="HOGENOM" id="CLU_084236_0_0_1"/>
    <dbReference type="OrthoDB" id="4472872at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="109"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="288" mass="31772" checksum="9205B67B4D30D872" modified="2008-04-08" version="1">MAERPRPTVLRRVLTAIIDPVDREEQGYHQYPTMRGLHDPENEGLSMGSANNPQLARRLTVATTHASTLIPPSDKLLVFRALTGIDTVPALAIPHHHPRSAPNVGIYTRVVRAEQAAAQQFRFFSILMNTCLGIQIVVAAALTALGAARGPHNAVTAFGAINTIMAGILTYLKGSGLPDRLKHYQNEWRNIREYIEQREREFCLDGCQLDVQAEVVFIESMYEGVKREIEATKSGENRSSAGPGQMPRSFLPQARAPELQKQPGKPVAGSPVSVPEPVLEKNQPYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA27</accession>
    <name>B0YA27_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCCH zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_083180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083180"/>
    <dbReference type="HOGENOM" id="CLU_030447_0_0_1"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="690" mass="75126" checksum="98698933EC629F3B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAG4</accession>
    <name>B0YAG4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_084580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084580"/>
    <dbReference type="HOGENOM" id="CLU_051696_0_0_1"/>
    <dbReference type="OrthoDB" id="4869700at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760550" description="GPI anchored protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38105" checksum="F7BBF4AFFA4631F1" modified="2008-04-08" version="1">MHLPKLFASGLVLLVVPSAVTARRGGGGGGIDTDTSSDGDGGSSSAPGGTSTIGGGSTSCGPTTEILYKSDLVPMNSYNWTSKGASNSGTNPTTYDGSYFQGEAFLHWQFTAGRPCQNSSGTVRMLGYAWVGPQPPYPTGPTNPIIIGFKAWQTNDALENITFSYDFLHDGLYCPTAPDLVKIQTSNGWTDYQASTDIPRADRARAHDVFDLDLALDAERPDSVRFNGSMVPGLKPPPTYTVEVLLPASACNRQSRLSLGYGEELNMSGSLTNTTLELSLAGVGKGSYASGSGIMLRAMFNITFSGTFDSGNSTRAVAIKPDTQPMVFWVDNGAMMHGCLSWMLKLMFIGWVAWFVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAP7</accession>
    <name>B0YAP7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_085400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085400"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="PhylomeDB" id="B0YAP7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF166">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G01210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="267" mass="29146" checksum="06EE6F6604B0275E" modified="2008-04-08" version="1">MRIVMDYSTQTERFILARTCQSSTRILTLDRPNKRNALCQTLIDELLQQLKIASADPHIRAIVIAGSGAIFSAGADIKEIAQLDGESARQKRYLEDLCHGMKQVRKPIIAAVEGRALGGGFELALMADFIVATPEVEFRLPEISIGLIPGAGGTQRVTAAVGKYRAMNLILLNEPLSGSEAYQVGLVSKLVEPGMALSGALEIAEKLASWSAPTLMVAKEAICRADELQHDHEFERSLYYATFGTRDMAEGVTAFLEKRAPVWRTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB31</accession>
    <name>B0YB31_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_091380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091380"/>
    <dbReference type="HOGENOM" id="CLU_006383_1_1_1"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="PhylomeDB" id="B0YB31"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="453" mass="51516" checksum="0055676804611F3D" modified="2008-04-08" version="1">MTSGSSNRRGSGQKSFFASSDETKICVVMVGLPARGKSLIAGKAMRYLAWVGIPAKVFNVGTYRRQGTPQPTATFFDPHNTEGERMRRAAAEAAMSDMLNWFKAGKGVVAILDATNSTKSRRQWIYETCRDADIETLFVESICDDEDLIMNNILEVKTTSPDYKGQDPEVAAMDFRNRIRNYEKVYETIDDNEKHFTYVKLINVGSTVIINQIKDYLSSRLVYYIQNLHIKPRSIWLSRHGESEYNLMGKIGGDSNISARGEAYARALPGLLRKSGVPSNAKVVIWTSTLKRTIQTARHLAAETGYEKLEWKALDELDSGVCDGLTYEEIAERYPDDFAARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSENVIIVTHQAVLRCIYAYFLNIPQEQSPWMEVPLHTLIKLTPRAYGTEEQRFKADIPAVSTWRAKGTSAKHQEFPTEVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB81</accession>
    <name>B0YB81_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_091880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB81"/>
    <dbReference type="HOGENOM" id="CLU_2126860_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="114" mass="12061" checksum="42303A82D37D7B6B" modified="2008-04-08" version="1" fragment="single">DQFNWRSFVLFDKFTIQSFNIYTLTMCFGLCEYDDERYSPPRRSNYPGYNYSGPNNCNYNYGYDNVRHRNGRRHHGLFATMPAEVGGSAAGCGGGGGGCGGGGGGGGGGGGGGC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB89</accession>
    <name>PLYD_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable pectate lyase D</fullName>
            <ecNumber>4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">plyD</name>
        <name type="ORF">AFUB_091960</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB89"/>
    <dbReference type="SMR" id="B0YB89"/>
    <dbReference type="GlyCosmos" id="B0YB89">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP48479">
        <property type="protein sequence ID" value="EDP48479"/>
        <property type="gene ID" value="AFUB_091960"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091960"/>
    <dbReference type="HOGENOM" id="CLU_044863_3_0_1"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="PhylomeDB" id="B0YB89"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF11">
        <property type="entry name" value="PECTATE LYASE H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394575" description="Probable pectate lyase D">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="242" mass="25397" checksum="61D7094F2D80D740" modified="2008-04-08" version="1" precursor="true">MYQKSLLFSLLASSALAAQFPIPDSKGSVTFDEPYEIAAGETYDGGYKTYGRGVSCTGQSEGGQDDTVFIVQEGGTLKNAIIGSDQIEGVYCLGACTIENVWWEAVCEDALSLKGGSGPYNIIGGGAQGADDKVIQHNSGGQVNIDGFTVYDFGKLYRSCGNCDEQYARTVTIKNVVANSGKTLVGINSNLGDTASIDSSTCATDVKKICVEYKGNDTGAEPEEISEGPSDACQYSEPLSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBD6</accession>
    <name>B0YBD6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoserine phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_092430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092430"/>
    <dbReference type="HOGENOM" id="CLU_058495_1_0_1"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="PhylomeDB" id="B0YBD6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="267" mass="30074" checksum="A8B496C86C0C6F82" modified="2008-04-08" version="1">MEGRHQYLNGNPKAIFFTDFDGTVTLQDCKQYILALFTSSYFSKPLLRSLSGNDYLVDNFGFGAEKRRMLELKVLNGTLAFRDAFQAMLDSVRLPFNECLRIVQENIQLDPSFVNFYLWAKEKSIPIVILSSGMTPVIEALLVSLFAGKPSNIFIVANNVAPHNGKHINMVGGWQIKYRDDSIFGHDKSLEIKHCVALPVGERPVVAFAGDGVSDLSAASQTNILFAKEGLDLMKYCKQKRIPFVAFNDWDSILDTMQDIYERTVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBP5</accession>
    <name>B0YBP5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_087370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087370"/>
    <dbReference type="HOGENOM" id="CLU_013387_2_2_1"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="PhylomeDB" id="B0YBP5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122531" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="177"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="414"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="489" mass="53601" checksum="AEECD8F65E2C8D0D" modified="2008-04-08" version="1">MVRNTPVIMALSIFATGALAAVDYPPIPSDLTTPFQQRLAVYGPNAISIGWNTFEKLDQSCVEYGISSNALTSRACSSISTTYATSRTYSNVVVLTGLTPATTYYYKIVSGNSTVNHFLSPRTPGDTTPFSMDVVIDLGVYGKDGYTVASKKIKKSDVPYIQPELNHTTIGRLARTIDDYELVIHPGDTAYADDWYLRVDNLLTGKDSYQSILEQFYNQLAPIAGRKPYMASPGNHEADCTEIPFTSGLCPEGQRNFTDFMHRFANTMPRAFASSSSSSTAQSLAAKAKSLSNPPFWYSFEYGMAHIVMIDTETDFPRRPRRGPFGSANQQLDFLAADLASVDRTVTPWVIVAGHRPWYTTGLSRCAPCQAAFEGLLYKHGVDLGVFGHVHNSQRFLPVVNGTADPKGMNDPAAPMYIVAGGAGNIEGLSRVGLKPAYTAFAYDEDYSYATVRFLNRTALQVDFIRSSTGEVLDSSTLYKSHTTQFTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBR4</accession>
    <name>B0YBR4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored serine-threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_087560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087560"/>
    <dbReference type="HOGENOM" id="CLU_1409146_0_0_1"/>
    <dbReference type="OrthoDB" id="5152093at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760832" evidence="2">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="198" mass="19448" checksum="A7ACB6B570FCA4B1" modified="2008-04-08" version="1">MYKLLTASLLATVALAAGHNGLIARQVSSCESHPGYKTCKSSCIPVTYSCCAIGEGGCEPGTYCTDDGCCPIGEICTGPGGTLTGTLTDTITNTLTNTVTNTLTNTHTETAAPTTTTTTEETTSTSTSTSTSTSASTPATTSKPVIPTQPTVTSPSGTPSPSGSSTASPSSPLFTGAASRLNAGVGAVAGLIAGAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC20</accession>
    <name>B0YC20_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_088610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088610"/>
    <dbReference type="HOGENOM" id="CLU_016622_2_0_1"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="PhylomeDB" id="B0YC20"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="603" mass="66839" checksum="49A8D71AEB6C5C5C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCA0</accession>
    <name>B0YCA0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_089450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089450"/>
    <dbReference type="HOGENOM" id="CLU_045430_0_0_1"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="PhylomeDB" id="B0YCA0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08864">
        <property type="entry name" value="SRPBCC_DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="102"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="323" mass="35193" checksum="823B7D01E6EA6A94" modified="2008-04-08" version="1">MKSSNLTSTVSTPLIRLSPHPFSSLPAHPSLSTSPSSSRPPLHSFLETALSEAHSLLTDTIPNTFKVDPKPRSSPPTTAKVQLLKGTIRHRKGSVRGEEEFWACRKSVHQDTAVDGSASWEEFRRGLRENHSENEMAYTPSVTSVERLLEWPTEGEIEGGWRQVGMHVNIITHTFHPTTLIAPRTFISLVISADLPNFVRQGFMTVQIPLAAKPTDAIPDEIREKVASAAPRNAVFASSASVEQVVSLATPAVTCNPGAARDGNGDTNQLEWTMATTSDAGGAIPRWIQRSWMMGGVPKAIVADVGYFISWTGQQRNNISYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCA7</accession>
    <name>B0YCA7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_089520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089520"/>
    <dbReference type="HOGENOM" id="CLU_032354_0_2_1"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="PhylomeDB" id="B0YCA7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:UMP kinase activity"/>
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        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
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        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
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        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP48238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="235" mass="25560" checksum="6C5BDB57230FFF04" modified="2008-04-08" version="1">MANTQNPPAVPPTQPAPPQASTNTTPRFSPQDVTVVFLLGGPGSGKGTQSANLVRDYGFIHLSAGDLLRAEQVREGSQYGDLIRTYIKEGKIVPMEITVALLSNAMAEALAAGAGATAEGGKKKARFLIDGFPRKLDQAVFFEDTVCPSEMTLFLDCPEEVMEKRLLKRGETSGRDDDNAESIRKRFRVFVETSMPVVRAFEEQQKVLSVSATGTVDEVYARIREGLEKKGVQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCR6</accession>
    <name>B0YCR6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_092940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092940"/>
    <dbReference type="HOGENOM" id="CLU_029244_1_3_1"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="PhylomeDB" id="B0YCR6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP47450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="391" mass="43790" checksum="EEA47170364FB648" modified="2008-04-08" version="1">MQRSNCHSSQVVRILRGARRPRIRAGKPVTSREVFRRWSSSETAKSSSAANQTIFSGIQPTGVPHLGNYLGALREWVRLQNAAKEGTRLFFSIVDLHALTVPQDASQLRNWRKETFATLIAVGLDPNRSTIFYQSAVHAHAELFWILCTIASMGYLSRMTQWKSKLQLPDNANLEDSTARSRLRLGLFSYPVLQAADILVHRATHVPVGDDQRQHLEFSRNTANSFNHVYGPIFPSPEAIISPAKRVMSLKEPTLKMSKSHADRRSRIILTDSPAEISKKINAALTDSELTITYDPVRRPGVANLIEILSHFDGRTCDEIAMEYHSASLRALKEHLARTLSNHLEPIREKYLSLVGDQTDYLDSIAEQGSEAARANAELTMEQVKVAMGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCS2</accession>
    <name>B0YCS2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Meiosis protein MEI2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_093000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093000"/>
    <dbReference type="HOGENOM" id="CLU_019467_1_0_1"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="PhylomeDB" id="B0YCS2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12528">
        <property type="entry name" value="RRM2_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034863">
        <property type="entry name" value="Fungal_Mei2-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="3">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="3">
        <location>
            <begin position="505"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="692" mass="76741" checksum="B064524375B75BD6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCS5</accession>
    <name>B0YCS5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_093030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCS5"/>
    <dbReference type="HOGENOM" id="CLU_149452_0_0_1"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="PhylomeDB" id="B0YCS5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="125" mass="13974" checksum="EB12D42DBBCA6522" modified="2008-04-08" version="1">MAKSVRASVTKRNRAKLRATVFGPAADARTERLSAKLKELASQPIIREHKSSSMELDSTGTEIKSPRNHIADIGVLLDMDVDTMSVKHTQSRSKKPGRVQKRKKARSSIVFQTHPLKTKKGSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCY0</accession>
    <name>B0YCY0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_093580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093580"/>
    <dbReference type="HOGENOM" id="CLU_003789_0_0_1"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="B0YCY0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF41">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="153"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1330" mass="146263" checksum="F7EECC4BC1C7D9CF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDD7</accession>
    <name>B0YDD7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_095200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095200"/>
    <dbReference type="HOGENOM" id="CLU_2132977_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="113" mass="12870" checksum="5E64DBC6683F8B19" modified="2008-04-08" version="1">MHLILHPKTLILLLAVLVTIVCISIRRFLARRQFARQHGCQPVARSLNKDPFLGLDTIPETLRAASQHRILERKPENIKTILSLNFKDYGLSHRLQPFKPLLGEGIFDTDGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE58</accession>
    <name>B0YE58_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMN dependent dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_097930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097930"/>
    <dbReference type="HOGENOM" id="CLU_020639_0_1_1"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="PhylomeDB" id="B0YE58"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03332">
        <property type="entry name" value="LMO_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="329"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="404" mass="44817" checksum="8B0AE922B92E7B89" modified="2008-04-08" version="1">MSTNQHNPLPYTYETKVYTEGLNDKKPAITFDPFKWEGLAKERLSADSFGYVWGSAGTRETDDNNRKAFRKWGIVPSRLVKSDFPNLKTTLFGEDYEYPIAIAPVGVQRIFHRDGEVAVASTAQNEGITYILSSASSTSIEDVAEANGDGSRWFQLYWPSNEHNDITASLLKRAKAANYKVLVVTLDTYILGWRPSDLENGYNPFLRKDNIGVEIGFSDPVFQKKFAEKHGKSIQEDMATAAAEWAHMIFPGMSHGWEDLQFLRQHWDGPIVLKGIQTVEDAKLAVEYGMQGIVVSNHGGRQQDGGVGSLDMLPDIVDAVGKDLEVIFDSGVRCGADVAKALALGAKMVLIGRPYVYGLAIAGREGVRHVLQSTLGDLQLTLHLSGIRSVQPEHLNRSRLRRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEJ1</accession>
    <name>B0YEJ1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_099360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEJ1"/>
    <dbReference type="HOGENOM" id="CLU_027977_2_0_1"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="PhylomeDB" id="B0YEJ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000043">
        <property type="entry name" value="Acid phosphatase PHOa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF23">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760647" description="Acid phosphatase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="414" mass="46132" checksum="CF97EF0C13ECD7B5" modified="2008-04-08" version="1">MFTKKSLVTLLGGLSVALAQTSSEQYPSLSEIEAAQATVLPHSPVSNVKGLAFDRFVNIWLENTDFDKAAADAHMSALAKKGLLLTNFWAVTHPSEPNYCAAAGGDTFGMDNDNFNQVPANVSTIADLFDTKNIAWGEYQEHLPYPGYQGFRYPESGPNDYVRKHNPAILFDSVTQDATRLRQIKNFTSFYDDLKNHRLPQHMFITPNMTNDAHDTNITFAATWSWNFLSELLENDYFTKDTLILLTFDENGTYKLGNKIYSILLGGAVPKHLIGKEDNTYYNHYSVIASLSANWGLPSLGRWDCGANLLSFIAEKTGYVNWEVDTSNLYLNHSYPGPLSTSSHTPNWPVPLTKGSCSAGHGILKAVRKTYKDMAPTYNYTSPVPYDAASKTNVGVKYTRKLVSLLDQSLTHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEU7</accession>
    <name>B0YEU7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_100430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3 8"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100430"/>
    <dbReference type="HOGENOM" id="CLU_025694_1_1_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="PhylomeDB" id="B0YEU7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF35">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="403" mass="45116" checksum="1F5BF86E8D4724C1" modified="2008-04-08" version="1">MFIRHSDTLKSAAKMVAAPMMEFYNKNQTEGIPGKLTDTWYVAGAMFMILIQYWYASSDDTYNTVVSHDLMFQSGENYDFFSKNYSHWLGNDDQMFWGLASITASETGFPEIPDKPTWTSLARAVFNMQVARWDTTNCGGGMRWQIPLYLPGYTMKNAISNGGLFELSARLARFTMNDTYAQWAEKIWDWSANTPLLQTDHCLLIIYGDKKTNGSEQWLERVNGLLNSLLRTFCPNDKGGNVLSEVACEPIMTCDRNQIGFKGYTAMWLAHTAILVPSTATRIYPVLQGSALAISKQCSKQPDNTCGIRWWQSTWDGFTPGLESQMAALGGITANLMYFKSTAPKTIDTNPDGKEHQITATHEDETTLDTPPPVDAANRAGAWILTVIFVLTAGGLVWWLVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEV5</accession>
    <name>B0YEV5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rhamnogalacturonase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_100610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100610"/>
    <dbReference type="HOGENOM" id="CLU_016031_7_1_1"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="PhylomeDB" id="B0YEV5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF18">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="466" mass="50264" checksum="FCE910F67BC51183" modified="2008-04-08" version="1">MPQRIQLDILASICEHHACTFSSLYPLGSGSGPAHRPFDCNILSYGAVADNTTDISTSLESAFNWCVRPNPGSRLVVPEGQYLISRGVVLSNATNWAFQLDGLITVAYGGNWTIDRALILEGLAGTDVLNTTINGEGDQKFLLDVLVIVNAVDFEFYSSNGLGAFQGQGYLYRNLNNTDRPRLVRLISPINASVHDLILVDSPKFHIVLDFAINVEAYHLTIRGANLGSYDGIDVIGTNYHIHDNEVTNRDECVSVKSPSHHALIENLVCNQAGSGISIGSLNVSAEISNILAQNISIIQGNNIAFIKTYPGGSGYVTNVTFSNFRSKASLYGLNINQYWQNTFEPDTGSVTLSNLVFRNFSGSVANGVQRPPLYLIANDLTYATNVTVEDFTVWTESGSSIVNKISNVFGHGDDSYGPNNGLVSLGAAEQPHTYTSTNIITASPTGWVPPKSPTWAAPSTGYGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF36</accession>
    <name>B0YF36_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_101440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101440"/>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="B0YF36"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="264" mass="27601" checksum="30DC9A1AE81F123F" modified="2008-04-08" version="1">MDFISTQHHDTYPFIAQATHHNHKVLITGASRGIGLATAHSFARAGAPSIAIAARGPLDTVETALLSTAKEAGHPPPTILKLTLDVADDASVAAAAEEVAAKFGHLDILINNAGTSEPWVPIAEKRPGGLVGMLGSQCQGRVPGHAGVHPAAAEGDAKDDCECQLGRGAVGSAGGVGVSDGEGMLAYAIHPGGVPTELAMGIKALQGLLTDTAELAGNAMSWLTQERREWLGGRYVSVTWDMEELLQKREEIVREDKLKMRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF50</accession>
    <name>B0YF50_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_101570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101570"/>
    <dbReference type="HOGENOM" id="CLU_045192_0_1_1"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="PhylomeDB" id="B0YF50"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012226429" evidence="5">
        <location>
            <begin position="16"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="293" mass="30459" checksum="18E9C56E1F97BF3E" modified="2008-04-08" version="1">MRLLPLVLLPLTAQAINIVSSNDDGWAEINIRQFYKALTAAGHSVVVSAPAENQSGKGSSDKTPTTRTKPCEFNSCPSGSPATGFNASDPRLNYVNSYPVTSMKYGISTAAPPFFNDAPPALAVSGPNVGSNLGLAVYFSGTVGAAHYAAEAGIPAIAFSGSSGSPTAWNAAVPAYSRVYAQLATKITNQIVASGTPYLPDQVWLNVNFPEVSSECAAADDFKFVLSRIFTGIFSADDVETCGSSRLPTESTVVGTDGCYVSISVGWSDKTDAAADVQAIVLDKLGDLLVCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF69</accession>
    <name>B0YF69_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitochondrial chaperone ATPase (Bcs1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_101750</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF69"/>
    <dbReference type="HOGENOM" id="CLU_010189_4_2_1"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="PhylomeDB" id="B0YF69"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="248"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="466"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP47182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="513" mass="57434" checksum="B7D0EC80C4CAE079" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJP4</accession>
    <name>H9CJP4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_m0450</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="17"/>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion membrane</location>
            <topology evidence="2 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353063.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJP4"/>
    <dbReference type="GeneID" id="11948061"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000009">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="16">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFE02844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="74" mass="7491" checksum="14A48B5A62B8FA50" modified="2013-02-06" version="1">MLQAAKIIGTGLATTGLIGAGVGIGVVFGALILGVARNPSLRGQLFSYAILGFAFAEATGLFALMMAFLLLYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM01</accession>
    <name>B0XM01_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_001780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001780"/>
    <dbReference type="HOGENOM" id="CLU_097257_0_0_1"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="PhylomeDB" id="B0XM01"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24795" checksum="DFD4FEA5D8DCBE25" modified="2008-04-08" version="1">MPPSNIIRAMQPLRACIPRSTITNSSIQASSLQSTRSSNFVRRTASTTAPVAKQPQQTAPELTPSSTIAPPSLRKYPYTLKIGTVVSVGRMERTVRVSHRHTTWDPYLRKSYPKITHYLVADPRNSLREGDVIEFSSGFPKSRNVRHVVERIVAPFGSAIEDRPPVMTREERDALRAEKRAAKWQRREARRSQNGEAQGVKEHVGRIRALIYERVGDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM33</accession>
    <name>B0XM33_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_000810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM33"/>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="PhylomeDB" id="B0XM33"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF10">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="57875" checksum="3D86C98F74FBCD0C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMA5</accession>
    <name>B0XMA5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_000390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMA5"/>
    <dbReference type="HOGENOM" id="CLU_055302_0_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="PhylomeDB" id="B0XMA5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="413" mass="47413" checksum="9F66E3C2FC3E2270" modified="2008-04-08" version="1">MSLTNGCFCGFAIDSLRIRRYPVELYPAKHTPRPVACGSGRRRSASLTPPSSSGWMPPALKGRSDHRIYLDEQTDDGPQHHDEIKNLVLNFLRAIRRQHTMKLTVFRNFATDIVGRMFVGDLGDDRAAPIGTRSNHIDRCRFTTSLDHIMFKSPVAKLKRKRNKGLRWISCAGTYSRWNDASIVDVLPETGRKTILQAETREYDGPYDSLIVNGADCMAAAFVSMFRHLFKCPTAMFQLQDEVDNAFRNLTISDVLHQETELHALPFLDAVMKESMRLAMKFDYRRAVPAGGLAVLGHYVPERTVVQFHSEALRNNRTTFGEDVSDFRPQRWLQADLDQWQRTRMEEALLFLRPNIPNSAEARAAWLELKRAAALIIWKFDLHPLNYEEVFIQDAVSPEQEYEIMVNFTPRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMS2</accession>
    <name>B0XMS2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chitin binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_013970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMS2"/>
    <dbReference type="SMR" id="B0XMS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013970"/>
    <dbReference type="HOGENOM" id="CLU_053021_1_0_1"/>
    <dbReference type="OrthoDB" id="120613at2759"/>
    <dbReference type="PhylomeDB" id="B0XMS2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757682" evidence="8">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="9">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="290" mass="29815" checksum="10F03358C66A004F" modified="2008-04-08" version="1">MKQTGTLVALAGLVSMVHGHGFVTSPKPRMPGPAMKAACGNQVEINQQSDNYGNIQGELQVAKGQSDYNADECNIWLCKGYKFDDNKDNVYSYTAGQTVDFVVDIRAPHTGVANVSVVDTATNTVIGNTLKSWTDYASTATGVSQDETNFSITIPDNLGSKCSEPGACVLQWYWFAESIDQTYESCIDFTVGGSGSGSGSGSGAGSSSSAGSGSSIPTATPSVAVTTPSTGNNVISTPTTMVTSVRPTATSAAGTGNGAGSSTSFPTSGTAEEQLSYIASVLKSLLQYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN32</accession>
    <name>B0XN32_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_014410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN32"/>
    <dbReference type="SMR" id="B0XN32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014410"/>
    <dbReference type="HOGENOM" id="CLU_020802_2_2_1"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="PhylomeDB" id="B0XN32"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="501" mass="54677" checksum="819B70CB2DB1585D" modified="2008-04-08" version="1">MDPDYKARKEAFVSGLAGGSILEINAVTLVASVSVFLWSILQSRLSFFTPYSAAALLVDFLLNVLAILFATTLYSSAPLLLNLLLISPALLILLSTKRPRTPVKAKPPRQSARAGKDDSKHATALPESLPIHPFLTTYRAAMMVITCIAILAVDFRIFPRRFAKVENWGTSLMDLGVGSFVFSGGVVSARSLLKSRINGSKRLPLAKRLIASTRHSIPLLVLGLIRLYSVKGLDYAEHVTEYGVHWNFFFTLGLLPPFVEVFDALATIIPSYEVLSVGIAVLYQVALESTDLKSYILVSPRGPSLLSKNREGVFSFSGYLAIFLAGRAIGIRIIPRGTSFSRSPEQARRRVLISLGVQALVWTTLFVLNSTYAMGYGANIPVSRRLANMPYVLWVSAFNTAQLFVFCLIETLCFPAVHRTTTQESESERVDFATSRIMSAFNKNSLAIFLLANLLTGAVNLSISTIDANTAQAIAVLIGYSSIITGVALALHHANIKVLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNS1</accession>
    <name>B0XNS1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_005300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
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                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
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            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Joardar V.S."/>
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                <person name="Anderson M.J."/>
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                <person name="Silva J.C."/>
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                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
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                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="257" mass="28051" checksum="6005BFA86EFA4ABC" modified="2008-04-08" version="1">MSRRAQVEEVYDSDPEEVAPSDPSASILSPAAIPPPGASNIPMRPAPEPRREIPKHFQCLYPVYFDKTRSRAEGRKVGIELATENPLARDIVDAVQMLGLNVGFEPEKLHPKDWANPGRVRVMLKDEDGNLINPKIKNKHHLYILVAQYLKAHPTTEESPYRLRIRGLPMPEKLPGAPPAPRGWKIGKILPIHSPAYSGGGVSDNPLKDAMAEMQSMGGMPGMPQIPGMPNLAGLMGEPSAASGSEKKKKDKKKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPD1</accession>
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                <person name="Dyer P.S."/>
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                <person name="Fraser-Liggett C.M."/>
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                <person name="Orvis J."/>
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                <person name="Sundaram J.P."/>
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                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="EDP56969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="57" mass="6657" checksum="FCE923FF36926B5A" modified="2008-04-08" version="1">MKYPFEVTTSTYDHRVWKTGLPVRSAILKLHAGQLVVGWVTTSESWLLYCGPIRHYY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPP3</accession>
    <name>MCA1A_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Metacaspase-1A</fullName>
            <ecNumber>3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">casA</name>
        <name type="ORF">AFUB_007090</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell death (apoptosis) (By similarity). Required for the apoptotic-like loss of membrane phospholipid asymmetry at stationary phase and facilitates growth under conditions of endoplasmic reticulum stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP56007" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.22.-"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56007.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPP3"/>
    <dbReference type="SMR" id="B0XPP3"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="PhylomeDB" id="B0XPP3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0053">Apoptosis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0788">Thiol protease</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_0000333616" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000333617" description="Metacaspase-1A">
        <location>
            <begin status="unknown"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="413" mass="45199" checksum="571774D794E201D5" modified="2008-05-20" version="2" precursor="true">MQNHHHQQSSYGGGYPGQAYREQHPPPNPYGYGQPSPQPGYGAPPPHNGYGQPPSGYGQPPPPTGNAVYGGRQPGMNQYQNTYSHGHQGGPPPPPTDPVAFGHGAPQGYSFQYSRCTGKRKALLIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVLLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEEDGYDEVIYPVDFRQAGHIVDDEMHRIMVRPLRPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMSGMVSTAVGFLKRATKGDEAYTRSKQTKTSPADVIMWSGSKDSQTSQDAQIGGQATGAMSWAFITALRKNPQQSYVQLLNSIRDELATKYSQKPQLSCSHPLDTNLLYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPP8</accession>
    <name>B0XPP8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich Repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_007140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007140"/>
    <dbReference type="HOGENOM" id="CLU_016204_0_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="920" mass="100785" checksum="0D0589BF4777063E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQE7</accession>
    <name>B0XQE7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain protein (Gli3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_009690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009690"/>
    <dbReference type="HOGENOM" id="CLU_046889_1_0_1"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="PhylomeDB" id="B0XQE7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="384" mass="42678" checksum="974D472F039B255E" modified="2008-04-08" version="1">MTESPGSPLSSIASDEMSDREDLKHPFSPSASTLPPSKRRRTGVASWDRNTPLSTTFQEDLPPTSPSTSISSDTSGDIPNSPTLLALIGGSQDDDYSGQGNDQVTVCRWEGCNVGDLGNMDDLVQHIHNDHVGNRQKRYSCEWSDCPRKGQTHASGYALRAHMRSHTREKPFYCALPECDRSFTRSDALAKHMRTVHETEALRPSDPVPKGHNVPASAVGTPTGTPVSKLQRIRLKLSQPKDETDRLSEIANDDAVVAEDLDELELPEFGPEIGFDEHELQLRPYDLYRLLRRQIHWAEKEGQELKEEWEKIRPKRKQAWLEKESIFDDVIDAELRLFSAIVATEGLPTESGNAPNGVQKVQQGHLAVAEAEASLSRDSMSIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQH3</accession>
    <name>B0XQH3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SIR2 family histone deacetylase (Hst4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_009960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009960"/>
    <dbReference type="HOGENOM" id="CLU_021544_2_1_1"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="PhylomeDB" id="B0XQH3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1600.10:FF:000006">
        <property type="entry name" value="SIR2 family histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="116"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="614" mass="67136" checksum="69AA7B70985CA672" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQJ1</accession>
    <name>B0XQJ1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_010140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQJ1"/>
    <dbReference type="HOGENOM" id="CLU_012774_1_1_1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="PhylomeDB" id="B0XQJ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21312">
        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="99"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="590"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="789" mass="87355" checksum="1311A09C6C5A4958" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQX4</accession>
    <name>B0XQX4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_011490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011490"/>
    <dbReference type="HOGENOM" id="CLU_020826_1_0_1"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="PhylomeDB" id="B0XQX4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="49439" checksum="3D6753D5EA3022AF" modified="2008-04-08" version="1">MRKTLLLVFIHGFKGDDNTFANFPDRLRAVVARALPAIKVTTVVYPKYETRGGLKECVGKFREWLQNRVIDLEVANRTTSPTVDPSVHVFLVGHSMGGIVAAETLLLLASEQPISTDAYSDVPSNHASVGCEANSKTAASSRLVEPGTFMFPHIQGVLAFDTPFLGIAPGVVSYGAEGHYKNVTTAYNALSEVAGLFGFGGANNASREGTNATQQTQARLLPSTPAGTPASAPDAAATPSWQRWGRYAMFAGAAGAVAAGGAAAMYTQRQRLTEGWDWVSSHLIFVGCLARPSELRQRLALLSTVYNERGIRCTNFYTCLGKGAPSLVESSTKQGKTSFSQRIIRSKHRTFCTLPAEVETGQGTPEFSESGLSWLKAINDTAADEVSAHISMFLPNQNPAYLELVADACRSVVESIDKGWYSTATGPPEEVGDTPPQTGKSNTPPNAESKFMDDDDVVFVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQZ0</accession>
    <name>SEY1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein sey1</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sey1</name>
        <name type="ORF">AFUB_011650</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQZ0"/>
    <dbReference type="SMR" id="B0XQZ0"/>
    <dbReference type="EnsemblFungi" id="EDP56454">
        <property type="protein sequence ID" value="EDP56454"/>
        <property type="gene ID" value="AFUB_011650"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011650"/>
    <dbReference type="HOGENOM" id="CLU_011270_0_0_1"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="PhylomeDB" id="B0XQZ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000384971" description="Protein sey1">
        <location>
            <begin position="1"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="769"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="793"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="2">
        <location>
            <begin position="49"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="830"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="864" mass="97451" checksum="B38052CCE8228D25" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR50</accession>
    <name>B0XR50_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-threonine rich protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_001930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001930"/>
    <dbReference type="HOGENOM" id="CLU_780687_0_0_1"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF16">
        <property type="entry name" value="RICH PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="355" mass="36322" checksum="0D29526833930734" modified="2008-04-08" version="1">MFSFDNKVTVELGEAENQVVHHVSVGSNDAPMFLPNRLNANIGDQVKFRFHNVNHTLTQSSLAEPCSSIGEFDTGFNQFNPEDKNNLVITLTVNSLDPQWFFCKQSQPSPHCHAGMVFALNPGDRMDAFLQNARRSTSDPISSPVSSLVPGRVAGSSSPFLAASSSLNPSSGAFFPTSTTASTSVTASASTTASTTASTTASTTASTTASTTASTTASTTASTTASTTASTTASTTASTTASTTASTTASTAASTTASTTASATVSTSSAASVSSSVPHPRSEDIFASSSTHLPLIVSPVRVITVTETVSCTGTADPSSIRRSISTSDSTSEGNWSITAPLGASLFTVFAMMVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS73</accession>
    <name>B0XS73_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly accessory protein Isa2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_026180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026180"/>
    <dbReference type="HOGENOM" id="CLU_1041982_0_0_1"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000014">
        <property type="entry name" value="Iron-sulfur cluster assembly accessory protein Isa2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="151"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="267" mass="29683" checksum="6981085E6A743220" modified="2008-04-08" version="1">MSLVRAFLLLQHQYSSVYFELSGFIYYRCFVSNPFHKTFSVLPPTLCLLCINCSTGRQSRTESEGRRGREGVDDQYLLSGSRGYHLPWLPRDLHISTLLGGGELRHQGISLVEHNPSTYDHRVWKTGLPVRSAVLKPHAGRLVVGWRLREITDPSSSQLATKEENPYHHLRITVTSGGCHGFQYLMSLEAASKIDPEEDTVFEAEPEQGTTSGAGEAKVVMDEPSLELLSGSTVDYTMELIGSQFKIVDNPRATSNCGCGTSFDVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS92</accession>
    <name>B0XS92_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Disulfide isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_026370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026370"/>
    <dbReference type="HOGENOM" id="CLU_021868_0_0_1"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="PhylomeDB" id="B0XS92"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760435" evidence="7">
        <location>
            <begin position="21"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="243"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="737" mass="82847" checksum="50861441937F5CF1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSH0</accession>
    <name>B0XSH0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_027160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027160"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="B0XSH0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001558">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757840" evidence="6">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="414" mass="45132" checksum="5AF4C8A543E9E3B6" modified="2008-04-08" version="1">MVFIPMSLFNLLSSMSSATVAPALEAIADDLKIRSQTLLIMSLSVYLLGSAIVPLVSSPLSEMYGRVIILSASNILIAYRFLAGLGGAGPFGIGSGMNSDLFPPQDRWKAMAVFTLAPLIGTAIGPITGGFLVQYESWPWCFYVVSIAAAVVQLAAFLLLRETYGPVLLRRKCARMRKTTGNPDLYTEYDGMSSTALLHKNLIRPFRLLATQPIIQVLSLYLAYLNGILYLMVATFPDVWTTIYHESESIGSLNYLSLTVGMTIAMQLGTRIAGRVYQRLCANNGGVARPEFRLPILCAGACIVPIGLFWYGWSARQSIHWIMPNIGAAIYAGSTVVQLICLFAASAMAAVMVLRSLLGFALPLVAPSLYTTLGFAWGNSLLAFIAIFIGIPSPLFLWFYGERLREKSTFARDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSR5</accession>
    <name>B0XSR5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_017330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017330"/>
    <dbReference type="HOGENOM" id="CLU_059206_3_1_1"/>
    <dbReference type="OrthoDB" id="5131368at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151">
        <property type="entry name" value="BLR2777 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151:SF3">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="39"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="33842" checksum="DF9BD7B6DD5DB6D8" modified="2008-04-08" version="1">MAFDQEGTAQLTETTTSYEPPPIYDTIADPIILRTLLVEDIYLLGGQFAILCQFAHPALAKGSYNHSNFATRIPNRLQNTARFLNAAVFGTQQDKAAIFSIIHRYHARVRAEDYDANDPELHKWTAATLFVAVVIVHETFFGELPRDKMEALYRESAVFGTSLRMPPEMWPTTLAEFWEYWNHNIETLEVTDMARKLSRDLLYPVHLPMWMRVLAPLSRLLTIYFLPERLAKEYDLQPTMLSRIQFQATVRVMRIAYPSMPQHLRQTLHRQYMEDLGKAVDRIRKTGHWAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTF1</accession>
    <name>B0XTF1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase (Glo1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_029190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029190"/>
    <dbReference type="HOGENOM" id="CLU_046006_1_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B0XTF1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="44"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="228" mass="24988" checksum="35EA145BC16443F3" modified="2008-04-08" version="1">MNADQGSNSSASTSSSLFDPGVFLPGGHNNDPPLPENSPTVGYKLNHFMLRIREPQRSLHFYINLMGMRTVFTMNAGPFTLYYLGYPPTSEDRADLPSWSARVAKPPVLTQTPGLLELYHVHGTEKADAEGGFNMSTGNTAPHLGFGHLGFTVPDVAGTLERLRKQGVPIIKELGSSPRESVPLSSWEEERGVGVGEIHPNYQKLFDQIAYVADPDGYLVELIPQDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTF5</accession>
    <name>B0XTF5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_029230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTF5"/>
    <dbReference type="HOGENOM" id="CLU_2573467_0_0_1"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="81" mass="9340" checksum="C89CE3C5F54CA7DA" modified="2008-04-08" version="1">MLNPRSWRSESPFNDRLPAAYAYVYLLPSRAKKSAQEQGGTIKHEFTLIKAFTVEFPEEQVGVLENNPHVHVEKDQEVKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTJ1</accession>
    <name>B0XTJ1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_018760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018760"/>
    <dbReference type="HOGENOM" id="CLU_033093_2_1_1"/>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="PhylomeDB" id="B0XTJ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="50261" checksum="1FDB1431A44F5509" modified="2008-04-08" version="1">MSSEQLAQSQKPTGEYRQYLPDLSLKRFQVMRGQDAHEYAHDFKTLRQPPWLHALYMHWLDLLQEPFKGVTTDGNVRPGLFTLQDEGVPIDKIVAATQSLLSILDDKQRQSLSYHIDSPEWRTWSNPEFLLSHKGLRLDEVTPPIRDAIMHILETTLSPEGYDKAVKAMRINHFLGELVDSPRVMNEFSYNFVLFGRPSPDRPWGWSFYGHHLCLNIFLYKSQIVASPWFTGAEPNEIDSGPYAGTRIMQVEERLGLQLMQSLAPELQAQARIFAQMHDPAMPPGRWNKDDQRHLCGAYRDNRVVPYEGIPAISLTEPQKQLLYGILEQYLLYLPARARQLKLAQVRQYEPETYFCWIGGFGDQDPFYYRIQSPVILVEFDHHSGVFLNNEEPKKFHIHTLLRTPNGGDYGMALRPLIPAVEGLNGKEITWEKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTP8</accession>
    <name>B0XTP8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_029490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029490"/>
    <dbReference type="HOGENOM" id="CLU_109117_1_0_1"/>
    <dbReference type="PhylomeDB" id="B0XTP8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="13">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP54890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="142" mass="15772" checksum="C0667C9B1E324380" modified="2008-04-08" version="1">MGWMHVTPCYCLKANASSVQYPVSIHLDTDSHYAIFVSFEVNSGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKSFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV78</accession>
    <name>B0XV78_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_032160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV78"/>
    <dbReference type="SMR" id="B0XV78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032160"/>
    <dbReference type="HOGENOM" id="CLU_024136_0_1_1"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="PhylomeDB" id="B0XV78"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="128"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP55153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="548" mass="61863" checksum="9BEB71770C02CB13" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVR8</accession>
    <name>B0XVR8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_033410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033410"/>
    <dbReference type="HOGENOM" id="CLU_026278_0_0_1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="PhylomeDB" id="B0XVR8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000450">
        <property type="entry name" value="PAF acetylhydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758403" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="384" mass="41719" checksum="127B2856CD7E1B68" modified="2008-04-08" version="1">MLNLSAKHLMFAALFARLLRNSNAVPFPGTVGPYHTSIATTQLIDHHRLDPYAPTPQPRTLMISLFHPVRPAACCPSRTSYMDPVTATFEDEQYAQAGIPAGAFGSLSLQNCKPCPNATSRRRVKGPEFPLVVFSPGLGNTRLLHSVMAQQLSSTGYIVVTIDHPYDAGIVTFPDNTTILAANITTDDQIVDDLDVRVRDVSFVLDELHRPSVISKLIPGQTCGLDTSKVGIYGHFLGGATAAEAMLSDSRLKGGINLDGSFFGSVMGLDRPFMIMAHEGKNLTTDATWGALWPKLKGTRRRFMIKGSTHGTFTDLAQAADILGLREEFPTQAAVFLGSIEGGRALQVIASYTSRFFDFVLKGKKVELLEMSSKEFPEVIAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVU4</accession>
    <name>B0XVU4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_022790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVU4"/>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="PhylomeDB" id="B0XVU4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="12">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="466" mass="49283" checksum="B0DA3A3C16185C3D" modified="2008-04-08" version="1">MRRVVVTGLGAVTPLGVDHLDSGAEGEGLLHATKTRNFAPDGFADHGTLFLFRCIGVRRTWKRLLDGHCGIVNVKHCDARFADLPCQIAAVVPVGPRQEGGWTASEWLSRDDERKMARFAQYAMAASEEALEDAGWKPTSFEEREATGICLGSGIGNFDEIYDTVVAYDKGGYRKVSPLFVPKLLINLGAGHLSMRYGFMGPNHAVTTACTTGAHSIGDAARFITCGDADVMLAGGAESCIHPLAIGGFARARSLATDFNDAPEKASRPFDADRKGFVVGEGAAMLVLEELEHAKARGARIYAELKGYGCSGDAHHMTAPKENGEGAWMAMKKALKNASLPPSAVDYVNAHATSTVVGDAAENAAIKSLLLGPEGKQNAAEINVSSTKGAVGHLLGGAGALESLFTVLAINENVMPPTINLDRLAEGFDCNYAPNQAQERQITVALTNSFGFGGTNSSLCFSKHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVZ6</accession>
    <name>B0XVZ6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_033550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033550"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="PhylomeDB" id="B0XVZ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="270" mass="29256" checksum="68CB4AC886D2311C" modified="2008-04-08" version="1">MATFQTILIIGATSGIGEELARQYHSSGKKVIISGRRTERLEALTAELPGLGSIQMDVKNLAALPSKMDQAFAKYPDIDAVIINAGIQRLLDFNTTDVSAAQYPTTDAITDEVTTNLTGPTVLARCIIEHFKASRPNQPCLLALVTSGLALVPATMFPVYCATKSALHSFTALLRNQLKHTSISVVEIVPPYVETELDKDHVDEVARRMGGTRPQAMPVKQYVDQVMQGLEVTDANGKIQKYVADGLPRAAVDAWVTALSPMAKLLHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW18</accession>
    <name>B0XW18_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_023260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023260"/>
    <dbReference type="HOGENOM" id="CLU_003573_1_1_1"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="PhylomeDB" id="B0XW18"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="13">
        <location>
            <begin position="75"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1034"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP54270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121221" checksum="B10E71770D74A619" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWE9</accession>
    <name>B0XWE9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS drug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_035660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035660"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_2_1"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="PhylomeDB" id="B0XWE9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="399" mass="43284" checksum="987D78D3F5DA9A9A" modified="2008-04-08" version="1">MQLHVTTLQCMGSALAYKGCLVKEVSHSPRRLDICIAFNSALGSSLPSGASSEIVSAFDLDKDHVPIVLLNSVYLAGFAVGPLVFGPLSEYLGRQPVLIGTYIGYTIFTTACALAPTYASLPAFRSLCGIHAAAPKAVLGGLYSDIYDEHGERGTAMGFFMLMRTLGPQLSPIISGYAALLSWRRVFRVALVIAGVSMARIFGRPFAIVVQEPILLFTSLYLALVYDVLYLFFQALTRSFSKVTSSHLFIFMCYSSYHNKALAAGQTWATVEEFRRLPLACLGGPAMVVSLFWLGWASLSVVNPIVPMVAGFFFAIGFLFFIAMLNYLTDAYQQNSASAQAAASTIRSITACSLPLTTKSMYGNLGIHWANFAVGICCLGDGGDSVHFRQIWRIVKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWP9</accession>
    <name>B0XWP9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_046890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046890"/>
    <dbReference type="HOGENOM" id="CLU_004083_5_3_1"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="PhylomeDB" id="B0XWP9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="740" mass="83592" checksum="42ADC056393031C8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWQ7</accession>
    <name>B0XWQ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benzodiazepine receptor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_046970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWQ7"/>
    <dbReference type="HOGENOM" id="CLU_091805_0_1_1"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="PhylomeDB" id="B0XWQ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="177" mass="19880" checksum="0148A7CD9EC75DED" modified="2008-04-08" version="1">MPWSFTLPQEFFTSPVLAVATPIGVGSLVGYLVNSHTKELYSRLRQPPLRPPAWVFGPVWTVLYGMMGYAAHHATASTTLLTPATAVASFQTLYTTQLVLNYLWMPLFFGARKPGWALADIVALGGTVGKLMAMWWDFDRTAFWMMLPYAGWLCFAAYLNVSVGWLNNWDFDSRDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX39</accession>
    <name>B0XX39_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">cAMP receptor (Car4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_047630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047630"/>
    <dbReference type="HOGENOM" id="CLU_024810_3_0_1"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="PhylomeDB" id="B0XX39"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="8"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="355" mass="39990" checksum="BB701600FE43028A" modified="2008-04-08" version="1">MDLTAAQLRTLTTVERVASTLSILGVITIIGTFALSRHFRNPMHRLIFINAFYNLFDFIATMIATSGPAAGNHSRLCQFQGFCLQMFPMADVLWTLAMACDVFLVVYYQFDVRALRKLEIWYIAIITSLVSIPAIVFLFIHTPEKGPMYGGVTLWCSISPEWVVFRVVFYYGPIWFLILIVLLFYILVGIKVVKLRHQFNISHTDHIALSSNISNNNPAFDQPRNTVAVTVQINIQSQPAAHDSSSPSEPKPQPSRNDPSSHNVNPGQKRSKHTNVSFRQYILMPMVFFLVLLATWVAPTINRLSALVDPSHVSYPLLLAVGAMGSLRGFWNGVVFITLGMKGWKREMQLKLIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX69</accession>
    <name>B0XX69_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_037020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with MCM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037020"/>
    <dbReference type="HOGENOM" id="CLU_033452_0_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="PhylomeDB" id="B0XX69"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000286">
        <property type="entry name" value="Homeobox transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP52536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="590" mass="64558" checksum="394502AF955769E0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXD2</accession>
    <name>B0XXD2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS peptide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_047900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXD2"/>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="B0XXD2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="563" mass="61409" checksum="CEE0E5AF4CE82B9D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXL3</accession>
    <name>EIF3E_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="1">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">int6</name>
        <name type="ORF">AFUB_037810</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXL3"/>
    <dbReference type="SMR" id="B0XXL3"/>
    <dbReference type="EnsemblFungi" id="EDP52615">
        <property type="protein sequence ID" value="EDP52615"/>
        <property type="gene ID" value="AFUB_037810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037810"/>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="PhylomeDB" id="B0XXL3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000365980" description="Eukaryotic translation initiation factor 3 subunit E">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="256"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <sequence length="451" mass="51739" checksum="F1BAC2B790A25433" modified="2008-04-08" version="1">MAANVSPSAETLSSGAAAHPSNTAEEIANQYNLLPKLIPYLDRHLVFPLLEFSSGQDDEKEIVRAKYELLKHTNMTDYVANLWKEINNSDDIPDEFVKKREEVLAKLQQYEEESAKITQLLQDESVVANLRSDKVANLKFLEEQHGVTVEMVNSLYDYGRFQYSCGSYGNAAELLYQFRVLSTDNDKVASATWGKFASEILTTSWEAAMEEVQKVKDSIETRLFNNPLGQLQNRSWLIHWSLFPFFNHDPARDVLTDLFFSPAYINTIQTNCPWILRYLAAAVITNRNRAHKNSSVYQKQLKDLIRVVRQEGYEYNDPITDFIKALYVDFDFEEAQKKLGEAEEVLRSDFFLVSTTDAFVEAARHLISESYCKIHQRIDIKDLSTRLGLNQDEGEKWIVNLIRDTRVDAKIDYKEGTVIMNHPPQSVYQQVIEKTKGAFFRTQVLSAAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXY2</accession>
    <name>B0XXY2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_038970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038970"/>
    <dbReference type="HOGENOM" id="CLU_045718_0_0_1"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="PhylomeDB" id="B0XXY2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000489">
        <property type="entry name" value="Putative peroxisomal membrane anchor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="12">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP52728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="416" mass="44046" checksum="888F75BE4B97B688" modified="2008-04-08" version="1">MQQAVSLSGTTVLPALAITRSGEPSAGGCIIGGNYRKQGKFRGPAEQWRSRPVPMSICHFLQDPSVASSPIEKRVAFLQSKNLTQEEIDLALSRAGEDTSAAASAVASTQGYQRPTQNSVYRPPPPPPGYGYPPYGQWQAPPEPPKRDWRDWFIMATVVGGVGYGLYTVTKRYIAPLIAPPTPPQLEQDKQSIDEQFSRAFALIEQLSTDTAALKSAEEARTERLDTALREVETLVADLKTASRRRDDETRRISDEVKSLKDAIPKALEGAREGNETRLKELGTELKSLKTLLGNRLSGSGASSTPVAGRTMSASTLPSVARSAEEASPAATSATTNGVTATPTTQESQLSPAQPGAGSTTGAAASSPLAQFGRGASIPAWQMAATNRSKTANQSTTAPAAESSSDDKEQQSATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY39</accession>
    <name>B0XY39_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparaginyl-tRNA synthetase Slm5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_039540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039540"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_1"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="PhylomeDB" id="B0XY39"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070145">
        <property type="term" value="P:mitochondrial asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="196"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="572" mass="63948" checksum="AA3DCD3FECE85B81" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY93</accession>
    <name>B0XY93_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein SUAPRGA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_040100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY93"/>
    <dbReference type="HOGENOM" id="CLU_072692_0_0_1"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="PhylomeDB" id="B0XY93"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="354" mass="40095" checksum="4DEF81A1007003A9" modified="2008-04-08" version="1">MLSLRTFARSVPRTLSRSIATASRSSFLSVPKNGFLQASLKQATRPSYAAFSTSSAFRQSPAEGKVLYKFKFSLSGLHLLIGHEFRWFHKAGFIQQNIKLTPIFFVQGDIELVAKLEDELKHEKASGLEDLETSVQNIQYVLQNNSWEVKDVPGEQEVVLSKKFGNEEIRLTFTVADLQNLSEQEDFDDSAFADEMDFQGHQPVNQGRGAPGTVAQHPEDRIAPADREIDDLDRDMEPSFPARVNITIEKPGNGSLLIQTVAQDGLFQIEEVSYFSKPDLAHAQTAEQDWTRQSLYAGPPFENLDEDLQTFLERYLEERGINAELANMIPDYIQVKEQKEYVRWLENVKNFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYR2</accession>
    <name>B0XYR2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cenp-O kinetochore centromere component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_041790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041790"/>
    <dbReference type="HOGENOM" id="CLU_042556_0_0_1"/>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="PhylomeDB" id="B0XYR2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37850" checksum="3B985A1B33EF3513" modified="2008-04-08" version="1">MRIIACIPQSTVMESPDRLKQVEEQLDSEISSIRRESNAKHIPVRNLQRRRRLLTSSLLSSDNFQKRLKARQAALAPTPISSLSDEVSPLVQAADKHAELNHHRVAFSTTTFPFKDPSPHSDHPNLLGVRIDICCRNGRFTKPYYVLLRRAGTGDEKRLRVHRHTIPAFIPIEKLERVYLPLPPTQDSTEEDAPLKPGKERVRKQDLRGLVRELRRQLVAWHLRVDAVNMLKEDLGGVQDGSVGGVMVESRLEPNDLGIVSVSPTTLEATYVRLEWEDGRVGRFKLSDTGVIERAVIIGDRGRDKRLETVFIGGDGRVETLLDRLRQHIISASGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZJ9</accession>
    <name>B0XZJ9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_034130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034130"/>
    <dbReference type="HOGENOM" id="CLU_027887_0_0_1"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="PhylomeDB" id="B0XZJ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58286" checksum="0C7521515FD7586B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZM3</accession>
    <name>B0XZM3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044540"/>
    <dbReference type="HOGENOM" id="CLU_1045764_0_0_1"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="266" mass="30043" checksum="E6A3EBF6A597CD5C" modified="2008-04-08" version="1">MDFWEAVVKPRTIPAYKANKSEYITEQISGSSLAQHYDTVIESGTAHAWFTNGLALVMLHVPKHEPDNLYYLCGPNLDVDWEHEQAFHQEQTAIARALCLCLMSFSSAHPLRRKYAPADGFLGNSALALLHIPYDDPITLCYYLCEPNMDVNAEDDQSFHQPTTAIARVFCLCFMSFSLPVRDQEWRNSARPGSQIWKTSFDHTRAQIPEEELQRTPPNSGYTGSQATSSEYAGSDYQPSSPLDLIRSLVVESPLRPGQCVRRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZU5</accession>
    <name>B0XZU5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxyphenylpyruvate dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_034410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034410"/>
    <dbReference type="HOGENOM" id="CLU_035063_0_0_1"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="PhylomeDB" id="B0XZU5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF57">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="339" mass="38381" checksum="66EF1AFBDBD9BE76" modified="2008-04-08" version="1">MSYQPAIMSASLGRAWLHDLAYKIDQAAEAGFKGLEIFYEDLEYEARKLSGTDNPTATHLLAAAAHIHGMCSTHGITIIGLQPFLFYEGLKDRTQHAQLLEKMKLWLQLAKSLHTNTIQIPANFLPAEQLIDDRDLIASDLRLLADLGAAETPAIRFAYEPLCWSTHIDTIEKAWDVVRRVDRPNFGVCLDTFNIAGRVWGDPAAPTGRTENADQQLQITLEWMVKEVDVEKVFYIQVVDAERMRTPLVAGHPFHVDGQPARMSWSRNARTFMYEEERGGYLPCEEVARAIIQGIGYQGFVSMELFSRTMSLEGSHVPVEHARRGIKAWEMLKERLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZW6</accession>
    <name>B0XZW6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_034620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034620"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0XZW6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="485" mass="54484" checksum="C7A3A164A84772DB" modified="2008-04-08" version="1">MEAVIVSWLIRVLWSNKLNQGIREQHQKHGKPSMPFPSTSFTRSDKLTEHKGDVVRLGPSELSFCSLSAHDTIYNTNSTSFITYGSFQSAVEGLCPPGVTFVSHHSPAEQKELRRVFQPAIRLAVAGGMEAHHKRRFSELVAGLNIKPGVPICVNLTGLLERLEWDLIGDLGLGYSVPDRLKDNWNSQKTHQNLIGVAFALGSFLLSRRGLKMLVDSFGPFWIPKYLDPAHLIDVALKQRAEGKSTFVSQAIPYKNEKYPHLTKQMSSNVTGLIYAAFETSESSTRAILCALMRDPVRYRNLQQEIRSKFSASKPITDSQLVGLPYLTACINEGLRLWPGLNGQFTSRVSTGAVVDGVYVPPGCLVSADLYTLQRHPRYWHDPDTFKPERWLDPKNPDEMRAFRPFSAGPRSCPGRQIALQKLRLTLAKFMFLFDMQFVNPQFEWDRDVPSGLLWSSVEVMVRMTLLEPPVEPVEAVETAEAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZX8</accession>
    <name>B0XZX8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_034740</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="6"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034740"/>
    <dbReference type="HOGENOM" id="CLU_033821_1_2_1"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="PhylomeDB" id="B0XZX8"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="169"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="359"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP52310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="508" mass="56353" checksum="09C99AB04D9D92EC" modified="2008-04-08" version="1">MLPVDGAQISLWGLKKSRQFILHSDGGGPVSQSYRVLSDIGRGAQHQLRSRAYHSSTVVLDNELISLTTSVLKETSLSSFIIFLQSIKSLTNLLSSSFLDSLFLHPHILRITMASRGLPRALRLARVAAPRTVISAALPRPALAKAATRVAASTAPVRGVKTIAFADSKETVYERADWPREKLQEYFKNDTLALIGYGSQGHGQGLNLRDQGLNVIVGVRKDGASWKEAIQDGWIPGKNLFDLTEAVQKGTIVMNLLSDAAQSETWPTLKPLITKGKTLYFSHGFSPVFKELTKVDVPKDVDVILVAPKGSGRTVRTLFREGRGINSSIAVYQDVTGKAKEKAIAMGVAVGSGYLYETTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGANGMDWMYAACSTTARRGAIDWSSRFKDTLKPIFNELYDSVRDGTETKRSLEYNSQKDYREKYEKEMQDIRDLEIWRAGKAVRSLRPENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y003</accession>
    <name>B0Y003_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MYND domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_045150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y003"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045150"/>
    <dbReference type="HOGENOM" id="CLU_069858_3_0_1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="233" mass="26720" checksum="407D8ACF13664550" modified="2008-04-08" version="1">MSDSNPDETHKCQSCKKAESKSVPLRNCFRCKSAIYCSRDCQKADRKTHKKVCASNAQANTGSNNQSASDTNATQSTKALEVDDFLKPFYRLHAKTWLHDHTEKETYKLLIDTYRLRLDDDYTFSGDIHEDNIYGGATDDGRAGFRRFLKSVERKPHLLPRWWTPAKAEECIRYGTNSANWSYLGYAVEKHDVVEHYANNLMRIQLRIFGDQVLGTRPSGQKRASMMRIANGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y010</accession>
    <name>B0Y010_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_045230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y010"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045230"/>
    <dbReference type="HOGENOM" id="CLU_2427559_0_0_1"/>
    <dbReference type="OrthoDB" id="4289261at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="105" mass="11258" checksum="8DB8702EB466F238" modified="2008-04-08" version="1">MSPSPPSTYSSTATRPPPRFIELRPKGEGVLITFPEGASGQVDSRRKRHAISQKNQRDRLKAALEQMARVLHAGGVGSGPRRSSGTRGLLSTEAGEYGGEGWLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y079</accession>
    <name>B0Y079_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_035070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y079"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035070"/>
    <dbReference type="HOGENOM" id="CLU_110768_0_0_1"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="217" mass="23154" checksum="8966E585D237E695" modified="2008-04-08" version="1">MCLDERMEPQTAATSKMSAYQTACAICRGLIQMPSRVEARTSIEKAATRSSILGYDTKTPKYCCGSVVDNQCKDGDPFTIGNGAVIPEVAALAGYVKASAITDTTCSNSLSITTSSNSASTAITACPTSTGDNTSPSSHDLAIGVGVGVPLGVIALASIVWALWERRRRLLVNISINIWRTAYINHILRSSRLDKQGRHRSWTATGVQNELDIGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0C3</accession>
    <name>B0Y0C3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyoverdine/dityrosine biosynthesis family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_035500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035500"/>
    <dbReference type="HOGENOM" id="CLU_542876_0_0_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0C3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="502" mass="55677" checksum="81EFCD2FAA942109" modified="2008-04-08" version="1">MFHKEAGISHLILDIILEHALNKFDPAPDRLQGAAKNFLPIIERFVAAGTRIEACLPAFPFKSANKVYKVLGSLPDKAEELALDRLNTMCARVREVYPPGLQVAIISDGITYNDTWAYGEALRQMAAQKQFMYIVFSRIKDLLDIPLPEQMSEIVYVANCTTFRRLLLNKYERADLDIDHEIASNPDTKLTYLGYRRFLESDLKYIFPRGAHRSAHSYKRDCKYLAKQMLIRGDAFAQAIKTSYPNHLRLSIHESVAGTKLSISLLNTKTGFTTPWHCSVAQLANGEWISAPMGEFRKDDRLELVYADGRPSHFREKPREGDAFGISESTASYLQRPKRLRASEYLGATLPSVPVSPGMSSPSAASTSSSGASVQGSAATTPETHSPPTFTWSGLGIVAEDNSNNASVPYGRRLIPQIMDSLAATEPERIVFSLATFSGDSLEFRPISARTFANAIDKTAWWLHNQVGRPDSIQPVGYIGPHDLRHVLLTYACVKAGYAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0I2</accession>
    <name>B0Y0I2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_046290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0I2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046290"/>
    <dbReference type="HOGENOM" id="CLU_044729_0_0_1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0I2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF12">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="63"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="350" mass="38399" checksum="6E480E9521C6E8AD" modified="2008-04-08" version="1">MLLPVTFQSFVRSVPLDLFAVGVVVDRLYIPFTMYFFSLVAAAGLAHAYTVVVAEQFMLKNVDPIVLPGQYKSHMHSFFGSDAVTINTNTSAELQAGCSTNENPNDLSVYWIPTLYLTEGGKHTPITPMRFSAYYVNIGDAEIPFPQDFKAVAGNAQGASQADVESVYGIQWMCEGVSNTDGGKDVAAFPTKTCPTHLQSILLFPDCVNPDTLDYAYSGTQNWSGSFRPANRCPAGMKRIPQLRFSVRYDLRKLLPNGWSGTPPLELACGSSYCWHGDFINGWVPEAAQNMLKATDKREFMQIDGPLGGGKDGSKCGAKNAHDQDPNHGTSDYEESVKMMSSKRSIGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y101</accession>
    <name>B0Y101_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_059120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y101"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059120"/>
    <dbReference type="HOGENOM" id="CLU_014689_3_1_1"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="PhylomeDB" id="B0Y101"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000104">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="578" mass="64251" checksum="7C2638A4C2946819" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1C9</accession>
    <name>B0Y1C9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein complex beta subunit SfaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_059800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1C9"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1C9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="387" mass="42909" checksum="C8289510B5245A22" modified="2008-04-08" version="1">MAADMSGEQMQAKITAARREAEGLKDKIKRRKDELADTTLRQVAQNQTDALPRIGMKPRRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLSSREGPTRVARELSGHSGYLSCCRFINDRRIITSSGDMTCMLWDIESGSKVTEFADHLGDVMSISINPTNQNIFVSGACDAFAKLWDIRTGKAVQTFAGHESDINAIQFFPDGNAFGTGSDDTSCRLFDIRADRELNIYQSDQILCGITSVAFSVSGRLLFAGYDDFECKVWDVLRGDKVGSLSGHENRVSCLGVSNDGISLCTGSWDSLVSALKAIKYSPLLFRFIVFLVFISQSLIFLFVVKLKVWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1J9</accession>
    <name>B0Y1J9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_049560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049560"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1J9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000819">
        <property type="entry name" value="General substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF62">
        <property type="entry name" value="HEXOSE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="498" mass="54183" checksum="8C090D13F8AE7A78" modified="2008-04-08" version="1">MFQVKISSSVSIMAIFPLTRYTAHMGASGLTLNFLVAGIATCAFWLFGYDMSVMGGLITEESFTSVFPEMKDANIQGIVIASFELGALAGALACLDLGDRLGRRLTVWFGMLFMLVGGTLQTSAWALSQLTVGRVLSGIGLGLQVATIPSWQSECAKAHSRGRWVMIEGGLQTFGVACGQLVGYGFFFVKGQAQWRAPVGIQLIPALIVFVFINFLPESPRWLIKHGLVEEGAYNLSKLRNLPLDHPELMFERDAIIASFEAQSELAPFSYREMLRNGKTKMFHRVAIGFFMQSAQQLSGINLVSTYANKILQESFGLAASTSHLIAAMGGLEYAVCSLLSVFLIEGLGRRRAFLWTTVGMSSCFAVIAGLQSTDSRTCQLTAAGFLFLFNTFFGLAWVGGPFLYSAEIAPLRCRAQANAFASAGNWLFCFVVVMIIPPAFQNIGWKTDVIFAAGGDPVEKEKTMPYNIPIEEARRILGLAESPSIAEVLNHDAKPSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1M7</accession>
    <name>PLB2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Lysophospholipase 2</fullName>
            <ecNumber>3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phospholipase B 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">plb2</name>
        <name type="ORF">AFUB_049850</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1M7"/>
    <dbReference type="SMR" id="B0Y1M7"/>
    <dbReference type="GlyCosmos" id="B0Y1M7">
        <property type="glycosylation" value="23 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP50983">
        <property type="protein sequence ID" value="EDP50983"/>
        <property type="gene ID" value="AFUB_049850"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049850"/>
    <dbReference type="HOGENOM" id="CLU_014602_0_0_1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1M7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF62">
        <property type="entry name" value="LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000373997" description="Lysophospholipase 2">
        <location>
            <begin position="1"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="2">
        <location>
            <begin position="31"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="588" mass="63239" checksum="D268F56BC6EABDD5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y203</accession>
    <name>B0Y203_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_050450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y203"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050450"/>
    <dbReference type="HOGENOM" id="CLU_113407_0_0_1"/>
    <dbReference type="OrthoDB" id="4843554at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760765" evidence="2">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="205" mass="21535" checksum="A6311105FCB2EB5A" modified="2008-04-08" version="1">MRALQFLALSGLMLASNIALAAELDRDDVPDRCWDVCSPVVGIAQQCDNTHRDDDRAEMNCICNSNRAPTLVPLCEACISQFRNDTRNGTHHDDDDDDDHDHDDHRRPHDNDAYDILTSCSFSTTTYNAAAATSILSTATGSITPTATNNASGSTGSGGNTGNSQPENTNNGSNAQPNNNAAAGSTVSKAASVAAVVGLIGLAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y259</accession>
    <name>B0Y259_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OefB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_061360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y259"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061360"/>
    <dbReference type="HOGENOM" id="CLU_085102_0_0_1"/>
    <dbReference type="OrthoDB" id="5294241at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23555" checksum="5BCA5A8079308275" modified="2008-04-08" version="1">MYPCLAFSHNRSSIRSTPSEASPTLINHVSTITDSFMGDGYFNSFDSEVPRAPPPSLDNDTLLDIHPRKTSFSDVLGMSSACAFPSWPKRPSLLSSDSEGSTASAYLSDEDLLFSSGPVSSSESAIEEESAAQEPAIGAHSLTTEQQIQMLRAAAEEEAHRARFLAQVQAHARAQQALRVAQMAATEKENTKSKKRRTFSDRKKRATFVRAIASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2F7</accession>
    <name>B0Y2F7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_051290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051290"/>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2F7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="344" mass="39390" checksum="BA750791D14EC999" modified="2008-04-08" version="1">MALEFLQNLPRPTIDRPFGIHLWPIFDKAFETVVGYPASEFKFVEGVTPMSTFKETAIALVAYYIIIFGGRELMKNRPAFKLNTLFMIHNFYLTAISATLLALFIEQLLPTLYRHGLFFTICDHQGGWTQPLIVLYYLNYLTKYLELLDTVFLFLKKKPLTFLHTYHHGATALLCYTQLIGLTAVQWVVIDINLLVHVVMYWYYFQSARGIRIWWKEWITRLQIIQFVIDLGFVYFASYTYFSSTYFPWAPNMGKCAGEEFAAFSGIAIISSYLFLFISFYIATYKKTAKTGRPRRNTGKQSLVDMKNFEVPSVTPAANSKATSNGAAVASGRANGPVTRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2H0</accession>
    <name>B0Y2H0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_051420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2H0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051420"/>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2H0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="159"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP51140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="251" mass="28047" checksum="C8D36938BCEA2CA9" modified="2008-04-08" version="1">MDSTDPFLQVQADVLSTLQSSRPLFSSYLRIRSLAKSPSNPELQQARAELEATLTDLTADLDDLVESVRAIEQDPYRYGLEIDEVARRRKLVDEVGDEVEKMREELQRVVTTADTAGGTKAHTGSTSGLPNPSDFDNVLSPSDDRGDDYYTALEQQRQMELMHEQDEQLDGVFRTVGNLRQQADDMGRELEEQAVMIDEVDTLADRVGGKLSNGMSRIKHIVRKNEDTMSSFCIAALIFVLVLLLILVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2P2</accession>
    <name>B0Y2P2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Choline transport protein Ctr, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_051460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2P2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051460"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2P2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="491" mass="53655" checksum="66A6D832D044E483" modified="2008-04-08" version="1">MSSLDLEKKPSVKPGSSDTSSGSDDADAIRLAEMGYSQDLQRNFVLIVYGLLWITFISICVASSLSELASAMPNAGGQYFWANELAPQKYARFASYVTGWFGYAGAIFACASVALSLGSAGVGMWQLGHPEFTVKPWHVVVAYEIINFFCYLFNCFGKSLPLVAKATLYISLISFLVILVTVPACAKTHPSASYVFGHFVNSTGWKQDGIAFIVGLINPNWIFACLDSATHLAEEVPQPEKNIPIAIMATVVIGFVTSWTYCIAMFFGLNDLNKLLSTATGVPILELYYQALQNKAGAIVLETLLLVTGMGCLIACHTWQSRLAWAFARDRGLPGHKLLAQVNKTLDVPLMAHTVSCFIVAALGLLYLGSSTAFNSMVTACITLLYLSYSCPILCLWYRGRNNIKRGPFWLGKWGLAANIVTIAWTVFCLVMYSFPATMPVTTGNMNYVSAVYGVVVVIVLIDWFVRGRRSFRGSQSCLEDAVASETETEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2Z0</accession>
    <name>B0Y2Z0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_052350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2Z0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052350"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2Z0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF10">
        <property type="entry name" value="CHAIN DEHYDROGENASE_OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="283" mass="30546" checksum="850DD8494457F4B9" modified="2008-04-08" version="1">MASRRLLKSLPSSIARPGRLFTVTTPVTVYRTFSSSTLCLDSETQKNGKPVATSTENAYPNFSLRKKAYVVTGGGRGLGLTIAEAMVQAGAQVHCFDRLDTPHPDFALSQEASKNLEGSIHYHHVDVRDREHLNQTIRTITKEHGQIDGLVAAAGIQRVKDAVDHTPQEVADLMDVNFTGVFMSANAVAEQMMQTKRPGSIVLVASMSGMIANKGLTCPAYNASKAANFEEVPGLKETWEKENMLGRLAAPEEFTGATIFMLSPASSFMTGSCLVVDGGHTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y326</accession>
    <name>B0Y326_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HLH transcription factor (PalcA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_052710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y326"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052710"/>
    <dbReference type="HOGENOM" id="CLU_015973_0_0_1"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="PhylomeDB" id="B0Y326"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="598"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="742" mass="80146" checksum="33B2703722F0977B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3D1</accession>
    <name>B0Y3D1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_053780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053780"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3D1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="350" mass="37222" checksum="CFE88DAD1AAA29D9" modified="2008-04-08" version="1">MTIPDKQWAQVVLEKGSPPVYKEIPVPKPGPDDILVKLRYSGVCHTDLHAMKGDWPLALKLPLVGGHEGVGVVVAKGELVTGFEIGDHAGIKWLNGSCMECEFCKQSEEPLCPRATMSGYTVDGTFQQYCVAKATHALKIPNGVPLDAAAPILCAGLTVYKGLKESGARPGQTVAIVGAGGGLGSLAQQYAKAMGLRVVAIDGGDEKREMCEKLGAEAYIDFTKSTNVVEDVKASTPGGLGAHAVLLLAVSEKPFQQATDYVRSRGTIVAIGMPAGAYLKAPVFNTVVKMITIKGSYVGNRQDGVEAIDFFARGLINAPFKKAPLKDLPRIFELMEQGKVAGRYVLEIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3E0</accession>
    <name>B0Y3E0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_053870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3E0"/>
    <dbReference type="HOGENOM" id="CLU_034817_1_0_1"/>
    <dbReference type="OrthoDB" id="14167at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3E0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="458" mass="52014" checksum="86B4D20DDA7DEBA6" modified="2008-04-08" version="1">MNVNKKLDRFKQWAGERMGGEVKTNLSDDFKALETEMNVKHEGGQDLRPMRWFSHSISKRSEGDDKEKTLPIAHLGSSMVSHGEDFDANSEYGRCLTSKRPCHSCCFTSDWLSDVVFYQIVFGRAEERIARVQETYISQATATYLESLERSLAQLKEYQAARKKLDSRRLAYDTSLSKMQKAKKEDFRVEEELRTQKVKYEEANEDVYRRMYDIKDAEVENIADLAAFLEAQLNYHERCREVLLQIKNDWPADQFQSQTPNGRRTAGRARSNTAHSHHERYEPLHEELTNGVSPRPIIRSDRHASSVPPTLPAREAYPAETPYQRPVLNRTSTFEGPSQLRHLQPSGLSSWQSRAASENLVSRRDSSQPRPVSMMPDNPYTDAYEESTAHVNSHSDVFYQGRSSPPSHGEIISRRASSGTLNGSALNKKGPPPPPPSRAKKPPPPPPMKRPMLSVGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3R3</accession>
    <name>B0Y3R3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyruvate carboxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_055120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3R3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055120"/>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_1"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3R3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="119"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="555"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="646" mass="69881" checksum="016D63A6394A5C51" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y432</accession>
    <name>B0Y432_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_056340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y432"/>
    <dbReference type="ESTHER" id="aspfu-q4wuk8">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056340"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_4_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="B0Y432"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="396" mass="44119" checksum="B5175C50830EE034" modified="2008-04-08" version="1">MASLPLPPNVSSRFISTAALNFHILEAGYSPDRNRPLILLLHGFPELAFSWRKVLPRLAEAGYYAVAPDQRGFGRTTGWDTRSYNEVDLSTFSLTSLARDMVILVHALGYRSVRCVVGHDCGAVTAAMCALIRPDFFESVLLLSHPFNGTPSLPFNTATNPDHVHGTPGSGSGMESAASNSIHAELAQRNRKHYKWYYSTASASNEMNLPPGRLHEFLRGYFHLKSGSCARNCPRPLKTWTADELLQLPFYYIMPLDATMPEAIALDMENEPENAQQLSQAWLPDSDLEVYVAEYGRTGFQGGLNWYRVRTAADGRFTQDFDTFAGKKIEVPCAFVSGEMDWGIYQEPGALERMVNGEVCSDFKFLRLIEGVGHWAPQESPEEVSNAILRLVRSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4P9</accession>
    <name>B0Y4P9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_069850</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4P9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069850"/>
    <dbReference type="HOGENOM" id="CLU_027221_2_0_1"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4P9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="72"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP50648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="497" mass="56886" checksum="604BEF4CEB63BC97" modified="2008-04-08" version="1">MDQHDDFDSVSWRQDPESDISRPTTSGTDADESLEYNRDTNGKRRMSSVHEDPPQAGPLADAVDLAGIGDGVLECRVDSPLKENDGTKDAYISYLVTTHTDFKSFQKPDFAVRRRFTDFYFLYKTLYREYPACAVPPLPEKHKMEYVTGDRFGPEFTSRRAWSLHRFLKRLTLHPVLRRAPLLAIFLESPDWNAHMRLHSTRTSTGNSDGSGTGIFDNFTDTFVNAFTKVHKPDRRFIEVKEKADKLDEDLNHVEKIVARVARRESDLEADYNDLATQFRKLVPLEPDVEVPLQIFAASVEETARGFKMLKDHTDQNYLGSLRDMEAYIVSVKALLKTREQKQLDFEALVDYRNKAVAERDSLAANPSSYYASNPLTSSPASFIRSKMEDMRGVDHEQSRRERVRKLELRIDELTREVESAKTTSEMFDEEVVREVADFERIKAVEFRDTLGALAEKHIDFFQGVINTWERFVAEMEGDLDNDPEMSEHGRGGGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4R2</accession>
    <name>B0Y4R2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_069980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4R2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069980"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4R2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="548" mass="61297" checksum="18C1D0A3228C9D69" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Y0</accession>
    <name>B0Y5Y0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_064970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Y0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064970"/>
    <dbReference type="HOGENOM" id="CLU_1777032_0_0_1"/>
    <dbReference type="OrthoDB" id="4343623at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="146" mass="15936" checksum="C77BF8CE55F23A3A" modified="2008-04-08" version="1">MDPDSDSTRDTQQPPEMTSRMQQAEGQGRDGTQATGSSTNTADMYSTTTSSLADLGNHISNMAGTTMAEIRNKASAVSAKDVVREVRDTAYSITMGNKQAEESTGTGVEDCDPQEARRIDELPKERIVEFLQERHKSNAVHPSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y619</accession>
    <name>B0Y619_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_065360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y619"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065360"/>
    <dbReference type="HOGENOM" id="CLU_040687_0_0_1"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="131"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="443" mass="50264" checksum="56E11A1BE037AC6E" modified="2008-04-08" version="1">MKRSLNGEHKQLQSSSTSHQVLEDGKPLLSTLDAPVSPPRRKGRNKKVSDDQPAPSFSSVTADSKLPSSEPSLAAIEAGLVEVTDHLKIFSSRLARCARPVSPQVPRLPIRDWVELYERNLHPNGRHFVIHQHDHPIAGPHYDLRLQFSETSSVSWSIMYGLPGDPNSRRLNRNATETRNHLIETASANTGSMIIWDTGEYEILPSQSAREIVETDDSRSEVSDSSLHSHVYKKTESEKLREAFRNNKIRLRLHGTRLPENYTIILWLDKNFDFAKPSTRIPRKRRRRTIRSSTTRPEPSTSSDSEIPDREPQDQSVDADADTMASHSEPESAIDRQIRMNNAYPGSTNTIGSIHQRRWFATLDRVNSGFVPEHESAESGSGKKRWVRKRNLRTGQELGFEPFYVRGPEVERSVVTGRLGKDVLEDEGVKHFVPRRGWRAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6C2</accession>
    <name>B0Y6C2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_066420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6C2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066420"/>
    <dbReference type="HOGENOM" id="CLU_1970030_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="127" mass="14015" checksum="BA659F65987A721F" modified="2008-04-08" version="1">MNCRSQVNWGQLKKMLEYPLGHAYIRSINDGSLRGRHSGGICATIIQPAPPTPIFQSSKAFKSTISFYLLNRELVIERSSSPRDAESDWYTTLPYTHGDASHLFSLALKCKETAGPNVEASAGDDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6J4</accession>
    <name>B0Y6J4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="6" type="ORF">AFUB_067170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6J4"/>
    <dbReference type="HOGENOM" id="CLU_075636_0_0_1"/>
    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="286" mass="30950" checksum="94CA1A20C22AF240" modified="2008-04-08" version="1">MRDTPSCVPGSGPQRHAHPRYMQFLSLSYYPNHGFIYTSQPPEKTAQSPAPNAATPQTGLTPALGSATPSNAAAAGGSGMVMITVPLPSSGALFKHFVYACQPFWCHRHTVAVPGGMVYDVGDFRVRIGDVRQTQPAARVRGTVVEIEYRGPSLVTSIAAQYVQSKRAVNLGGATDVSESDHDSGIDLPLFGGIEDADIDAEYSATAALIREFWSKLGIEGAREAILVPDVGREVKEQLKRLKLQEKTGQTAPRNEGHALQQDDDPDPDAGTDLARQFMEIFRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7B8</accession>
    <name>B0Y7B8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endosomal cargo receptor (Erv14), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_073260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073260"/>
    <dbReference type="HOGENOM" id="CLU_112942_0_0_1"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7B8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="138" mass="16104" checksum="7DB04F28507C713C" modified="2008-04-08" version="1">MSGEAWLYLLAVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNAYIIPEAAVHAFLTILFLINGYWLALILNLPLLAFNAKKILDNQHLLDATEIFRKLNVHKKESFIKLGFHLLMFFFYLYSMIVALIRDESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7D2</accession>
    <name>B0Y7D2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_073400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7D2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073400"/>
    <dbReference type="HOGENOM" id="CLU_1712833_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="153" mass="16799" checksum="2A60093F6CB65A86" modified="2008-04-08" version="1">MQTGRSENHSKLWTASRPSHRTPAILSPPHQSHIGPASPLAFEITRGRQHSHRLVHDPLANAEIVIDPFLEVFVIGDLVSVETRAVRTPRGPDQDAGKQISFSPSTPSPPTVERLMPARKAETIKSIHQLSVIPLRITTKPADKYLQSTASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7Y1</accession>
    <name>B0Y7Y1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_075410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075410"/>
    <dbReference type="HOGENOM" id="CLU_1488683_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="181" mass="20732" checksum="AA4BF1239E7A308F" modified="2008-04-08" version="1">MQNLAVWLQECIYFRAFQRPLQGSKAKYLHRFLCRSRLHNLLQVRKGGNASFQIVEERPGHSKFRAIWAFKELLERAFTLLTYSPLHDAPSQLDNTDNTGCTGKRVHNQRGCRVQDLHATLSPPILLSVVYYIDRLSAFFPVLTLSSLTVHRYLITSALLPARVLAILSEQTEFTSVYHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8L6</accession>
    <name>B0Y8L6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_077790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8L6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077790"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8L6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="351" mass="40882" checksum="63B2D650427A5B88" modified="2008-04-08" version="1">MKWATKALRRAPSPPMCFPTSGFETIRPSEVLDEARFEHFKKGQYYPANIGYVLSTKYRIIGKLGFGTTSTVWLARDLEEEFQIYKQLNQGSRQHPGRPHIRQALDIFTIPRPGGDHQCLVQKPMWESFRDLLYCNPNHRFSEDLLKAGLMQIFLALDYLHTECKLVHTDIKSDNLLQEIQDNSILDMLSDFGSAVRGDQRRNHDAQPNVYRSPEVMLKVDWSYPVDIWNVGVMVWDLFEGKHLFYGNDSDGKGYSTRAHFAEVMSILGPPPLDLLQRGKRSHEFFTDEGKWKQDIEIPTGVSLEMSEEYLEGRNKEMFIAFMRGMLQWRPEDRKTAKDLLQDPWLNDRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y932</accession>
    <name>B0Y932_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_079460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y932"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079460"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="PhylomeDB" id="B0Y932"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF15">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="261" mass="28542" checksum="2D0718C69DAFA4D5" modified="2008-04-08" version="1">MSFPYKHVLLIGATSGIGCAMADRLVEAGIKVTAVGRRKDRLDEFVRKHGEQLASAVQFDITVHEDISKFAAKIIDSYPDVDCLFLNAGIQLPFKLDDRGQFDLEPFSKQMNVNYFSLVALTHAFLPFLVGKQSPTSIIFTGSNVAIVPAASLPAYSASKAALNVFTLSLRDQLRNSNVAVIEISPPPVQTEIHDYMGKEVGSKLGMPLDAFADLAFQRLVAGQDQIVIGSIGPAERFNAIIDQRRAAFEDLAEVMRAQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y963</accession>
    <name>B0Y963_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_079780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y963"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079780"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="PhylomeDB" id="B0Y963"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="588" mass="62231" checksum="3FC8EBCB9A87753A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9C1</accession>
    <name>B0Y9C1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pectinesterase</fullName>
            <ecNumber evidence="4">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_080500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9C1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080500"/>
    <dbReference type="HOGENOM" id="CLU_012243_2_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9C1"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000045">
        <property type="entry name" value="Pectin methylesterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011119501" description="pectinesterase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="10">
        <location>
            <begin position="174"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP48614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="408" mass="44473" checksum="A848128A4B997E01" modified="2008-04-08" version="1">MRPSSALLALGLLPEALCKSVHPAETYKSCQRITPDPLQGCPHGTLFVSQTDHRAHFKSIQAAIHSLPNDTSSHVILIGAGTYVEQLNVTRSGPLTLLGQSNRPWQRESYGDINPNTTVQNDVQIYWNAANHNAAFPDNVYTGVLTVGPTYNATITGAGPTGYPVPADTPFGCSDFRAYNIDFRNEYVPYSDGPAHAVGLGYANAGFYSCGLYSYQDTLYVGKLANAYFYDTVIAGETDFLYGFGTAFIEKTTLSLRGCGGGITAWKGTNTTFENKYGVYIADSQVLAANASIENDIKERCSLGRPWNNLHRSIFIDTYFDSSILPAGYTVWKGAPNNNFNNETLMAVYGVYGPGYNPAAEKNGNVTRILHRKEVMPYARPVDVFMTPDGHQPNIAWLDPIAASSGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA58</accession>
    <name>B0YA58_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-N-acetylglucosaminidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_083500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA58"/>
    <dbReference type="SMR" id="B0YA58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083500"/>
    <dbReference type="HOGENOM" id="CLU_008392_3_0_1"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="PhylomeDB" id="B0YA58"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="638"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="931" mass="101446" checksum="73B53650E1C2ACBC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAK5</accession>
    <name>B0YAK5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridine nucleotide-disulphide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_084980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084980"/>
    <dbReference type="HOGENOM" id="CLU_021377_8_0_1"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="PhylomeDB" id="B0YAK5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF45">
        <property type="entry name" value="NADH DEHYDROGENASE-LIKE PROTEIN RV1812C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="410" mass="43658" checksum="6D20C2B3636416E5" modified="2008-04-08" version="1">MSSKIVIIGAGFAGVWSALSAKRLITCRSKESEVEIIVIAPEPVLVMRPRLYESKASSLIHPLETLFEEAGIRFVPGVVKTIHTERRAVEVQCASGFESTIDYDRLILAAGSSVVRPQGVAGIRQHAFDIDSLNSAVKLESHLNGLASLPASPGRDTVVVCGAGFTGIELAAELPRRLGHIANARVILIGNADEVGPDFGSSPRSTITQALKDLGVEVRLGSGVKAVDPDGVTLASGERIQTKTAIWTAGVRATPLTQQIPGPKDALARLYVDQYLRVSSVDGVFATGDAACALADGKNQYSLMCCQHALQLGRVSGYNAAAELLGERLMGYTQAAYNCCLDLGSWGALVTAGWERENIKISGDIAKRVKCYINQQLIYPPTDAHQALAFADPVGPDSDQLFEHLVRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAM0</accession>
    <name>B0YAM0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_085130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085130"/>
    <dbReference type="HOGENOM" id="CLU_013394_0_0_1"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="PhylomeDB" id="B0YAM0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000198">
        <property type="entry name" value="TOK2 potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000544">
        <property type="entry name" value="TOK2 potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
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            <end position="350"/>
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        </location>
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            <end position="231"/>
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            <end position="384"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP49063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="566" mass="63074" checksum="E708D83861774C58" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAR4</accession>
    <name>B0YAR4_ASPFC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">AFUB_085560</name>
    </gene>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
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        <location>
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            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="56780" checksum="8AFF85F244031C77" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBA2</accession>
    <name>B0YBA2_ASPFC</name>
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            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
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        <lineage>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
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        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
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            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="164" mass="17803" checksum="F50AAD9E8964AD16" modified="2008-04-08" version="1">MAFVHVVVATGVAMVGTGASGLAGKNPEASDQTNLDVGMALLEACWATLTVWALWTLKDCSEKTVLGVMEGNMVHFNLTQEILQLLRGVLLATAFIGIRVTYGLIAESTQKRNLNPVTGSLAIRTVLGLLPELITTLILMFVGFRTRHIDGISYNRRMVQQDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBH8</accession>
    <name>B0YBH8_ASPFC</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">AFUB_086640</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086640"/>
    <dbReference type="HOGENOM" id="CLU_778654_0_0_1"/>
    <dbReference type="OrthoDB" id="5273847at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="193"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="320" mass="36186" checksum="2875E80CF5B60620" modified="2008-04-08" version="1">MGKITFYCNICGGPLSCYDLRKASTAQQGEDLSLCYDDDCDCDAGTRPEAEGDEDGEDDENLTTVCEHDSYCASLRGYSGHLISEEDILWLEKVRMLRPRDSLSDKHDEMQDDDDAYYITENSRAGCISLCRLDYGMTWRNPSIGRTVESMVWLVADPLKPVDISELVAVAKNLKRGSTNAIVNGGALELSGVDPFSSLPWDVRYRILQMLPSPSIINMVIASAAFRGATCDLPDSFWRLRLDYDCPWIDQGSLRQKIAQTGGQVNYKALIRLIKEAAARPEDRMNKDQDSWLNFRNRHRIWTCCEVILRKLEKEVNLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBK3</accession>
    <name>B0YBK3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_086910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBK3"/>
    <dbReference type="HOGENOM" id="CLU_030571_6_1_1"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="PhylomeDB" id="B0YBK3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="298" mass="33610" checksum="CDE7D656B906C28D" modified="2008-04-08" version="1">MEPGEPTIHDVFESKTGTWQYVVADPTTSTAVIIDPVLDYDPATQGITTESADALLSLVKEKGYKVDRILETHAHADHLTAASYLQKRLAEEQGHRPRIGIGKRIGQVQKLFGQRYGIPEQEYKDVFDKLFEDDETFKIGNLMAQAIHLPGHTPDHLGYRIGDNVFCGDLIFHSDIGTARCDFPGGSANNLYRSGRKVLGLPDHVKVWTGHDYPPEGRKEPVPSLSVHEHRQQNKHLRDGVTEEEFVTLRKERDSKLAEPRLLHQSLQMNIRAGRLPKPTESGQRLLHLPLKLKGLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBU3</accession>
    <name>B0YBU3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_087840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087840"/>
    <dbReference type="HOGENOM" id="CLU_012103_1_0_1"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="PhylomeDB" id="B0YBU3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="593" mass="63856" checksum="EC818851226B4756" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC13</accession>
    <name>B0YC13_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_088540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088540"/>
    <dbReference type="HOGENOM" id="CLU_033465_5_0_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="PhylomeDB" id="B0YC13"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="203" mass="22331" checksum="74FABF302348BC0B" modified="2008-04-08" version="1">MQSTLLLVAPALFAASIYMELGRIILLVKGEKFAIIRVTWMTKIFVAGDVLSFLMQASGAGILVTDNQSTGENVIVGGLFVQIIFFGFFVISAFVFQRRITAHATPESVAEYIPWKKHMGALYASSILILVRSVFRVAEYLQGWDGSLLQSEVFIYVLDGLLMWFVMATFLVVHPSEINCLLGRGKMMTAKGGLQVCEAAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCM6</accession>
    <name>B0YCM6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_090730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090730"/>
    <dbReference type="HOGENOM" id="CLU_924668_0_0_1"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="304" mass="34891" checksum="F5FD60B6D2E922AA" modified="2008-04-08" version="1">MPSSAEQTFSIYELVEHILLQLDHPVEITRAQRVCRHWRDVIQTSPALQEACWYQVITKDAESRPIATEPTWKLNPAFNRIGVSLSSDAAKGGGQGLGEFSLEEDIYDEPGSWTTMLVTQPPSQRILVKCHSYYSDDQILFYLIASRAGPLLMGDIMAVLAECRNRQDCGIDRWGGLRHYTGELVRWEEEKWEPYHWAALDRMPDDVSINVAIEMPWGYGGCPAFSLRRVYGTERFLHEMILHEMIMDQGREYQWAETSSGPQYRPVNKSKYRANLLAVKEHRGRYLSTCSTVFRLLSEVNQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCW7</accession>
    <name>B0YCW7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypercellular protein HypA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_093450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093450"/>
    <dbReference type="HOGENOM" id="CLU_002231_0_0_1"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="PhylomeDB" id="B0YCW7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="367"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="699"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="861"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1423" mass="157513" checksum="C629F1388121E14F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD48</accession>
    <name>B0YD48_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidyl-tRNA hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_094260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094260"/>
    <dbReference type="HOGENOM" id="CLU_089470_1_1_1"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="PhylomeDB" id="B0YD48"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="51"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="208" mass="22746" checksum="8F06794D9B5FCDCB" modified="2008-04-08" version="1">MPHPATPTTLQQSLSILRTSLLPKAIHPPPSLRRSFTLASSLSAKQLPPRLKIDDADLTVSYLKGTGPGGQKINKTNSAVQLIHKPTGIVVKSQATRSRSQNEKIARQILADKVEELLKGDASRNAIRAERARKKKASKMKKTRRKYRELGKGAQNEKHEDGDEVDVEDDTGDGSEVQGAPHVSRCDAEDSTTQKTCDNHAAEQKQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD70</accession>
    <name>B0YD70_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_094500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094500"/>
    <dbReference type="HOGENOM" id="CLU_808848_0_0_1"/>
    <dbReference type="OrthoDB" id="4167490at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="358" mass="41616" checksum="9B62678047925236" modified="2008-04-08" version="1">MSERIIQPHEIRQGHDSEQLNQVSSPGQAQSRLECLPVELLQKIFLYSLEFSLPRASIYLARALSNPTLYTWLIRLSFSSSNESSKNGFFTTEFLPPPLDFFALSTEERSDLQSAILACRWCTLELMRKCQREYIEHAVRLKCHGLVFAPEDRDSIAKIGEHFHDLSRYDQGHRGRLGKGDLVFRAQDPETNAEYRIAVWFNFGAFQIRRPNPFHTELDLFRLPCCAGDTPARMPSKLLCSPWTEAKLEFLKLLCTEVYIDDDEEFERSGRLLRQVIRSRDYGTFKVLVELFIRIRIYKYPRRWPIQRSHFKAALKYADSPNDPFLNFLIRERWDDLPSSDTKLKVEVLAKGGLCSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDE4</accession>
    <name>B0YDE4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_095270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095270"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B0YDE4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="268"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="707"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="98700" checksum="FAA81973FC123BD3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDJ4</accession>
    <name>B0YDJ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_095800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095800"/>
    <dbReference type="HOGENOM" id="CLU_2869191_0_0_1"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="69" mass="7623" checksum="56E9D64DC91B7197" modified="2008-04-08" version="1">MPVIPSDTSNFPTAQGSNNPEDNSSKGSEREQKKATAFDHISKGPQIPDSMPPKASRDEIEQRKKELNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDW7</accession>
    <name>B0YDW7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plasma membrane zinc ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_097050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097050"/>
    <dbReference type="HOGENOM" id="CLU_027089_1_1_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="PhylomeDB" id="B0YDW7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF55">
        <property type="entry name" value="MEMBRANE ZINC ION TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="532" mass="57875" checksum="6ABD7B18AFCF0179" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDY5</accession>
    <name>B0YDY5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_097230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDY5"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B0YDY5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="5"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="349" mass="38222" checksum="21787256A4502190" modified="2008-04-08" version="1">MNYGPSFTGLETLRMNIAALYGSESEAVISPSNIITTPGASLANFIVFFALVGPGDHVIVQNPTYPQLYSLPSGLGAEVSLWQASESNHWQLDLDELERLIQPNTKMIVLNNPQNPTGAIITKSALGKIVDLARRHSITIFSDEIYRALFHSIPPTDPEYPPSLLAFGYEKTVVTCSLSKTFSLAGIRVGWIASHSSSIIDLCLNARSYTVITVSQIDEQVAAMALEPVRLRELTKRNLGLATHNIEIVQSFIDRHAAVCEWVRPAAGPVGFVKFSRNGVPVDDLELCVLLLEKKGVLLVPGQKCFGEEFKGYVRLGFGQSTQALEAALEALTTFISEDYEMVPLAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEA2</accession>
    <name>B0YEA2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xanthine-guanine phosphoribosyl transferase Xpt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_098460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEA2"/>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="PhylomeDB" id="B0YEA2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19505" checksum="5D1D231C00D611A6" modified="2008-04-08" version="1">MIAIGGGGYVPARILRSFLKRPGEPNIPIQAIGLSLYEDLGRGDPEEVPGTKVTRTQWLDLSSLEMANLIGKNILIVDEVDDTRTTLEYAVRELQKDVEMAQKQLGREAEKTNFFVFVLHNKNKLKKGELPADMMESGRYLAAVTTEDVWICYPWEATDIEEHDRLAMETPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEV7</accession>
    <name>B0YEV7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_100630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100630"/>
    <dbReference type="HOGENOM" id="CLU_001265_2_2_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="PhylomeDB" id="B0YEV7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="94"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="553" mass="63589" checksum="A74E75C8E6DE9086" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF42</accession>
    <name>B0YF42_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_101500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101500"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="PhylomeDB" id="B0YF42"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="504" mass="55944" checksum="3C167B125B55A31E" modified="2008-04-08" version="1">MEEEKGISELKTTLAHETAHEAASRGHVATDQYGRALVEFDRAAESRLRLKIDLYIVPTVSLLYLFCFIDRANIGNAKLAGFEKDLGLKGYDYNALLSIFYISYIVFEIPCNIACKWIGPGWFLPAITLGFGICSLGTAFVHNIHAASGVRFLLGIFEAGMMPGIAYYLSRWYRRSELAFRLSLYIVMAPLAGAFGGLLASGILSLDHFGGLRTWRMIFAIEGIITIGLALISFFTLTDRPATARWLTQEEKDLAIARVKSERVGTTEVLDKIDKAKTLRGIFNPVTLATSFIFLLNNITVQGLAFFAPTIVRTIYPHNSVVSQQLHTVPPYVVGAFFTVLFPFLSWRFDRRMVFFVIGPPLMMAGYIMFLASTDAMIRYGATFLIASGAFAFGALCNANASNNVVSDTARSSAIGTTVMMGNIGGLISTWSFLPFDAPNYHIGNGLNLATSSMTMLLGALLWGWMRWDNKRREKVDVDQALAGLSLLQIQDLDWRNPAFRWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF45</accession>
    <name>B0YF45_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase/response regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_101530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101530"/>
    <dbReference type="HOGENOM" id="CLU_002763_0_1_1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="PhylomeDB" id="B0YF45"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="207"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="673"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP47158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="809" mass="88377" checksum="14A82C04C445D291" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XLZ0</accession>
    <name>B0XLZ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L31e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_001520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XLZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001520"/>
    <dbReference type="HOGENOM" id="CLU_112570_1_2_1"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="PhylomeDB" id="B0XLZ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="123" mass="14007" checksum="D66548F5ACA92349" modified="2008-04-08" version="1">MSSTVKTTGKKTRSAIADVVTREYTINLHKRMHGVTFKKRAPRAIKEIRAFAERAMGTKDVRLDPQLNKKVWEAGVKGVPFRLRVRISRKRNDEEGAKERLYSYVQAVNVKDAKGLHTAVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM08</accession>
    <name>B0XM08_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuole-associated enzyme activator complex component (Vac14), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_001850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001850"/>
    <dbReference type="HOGENOM" id="CLU_007740_0_0_1"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="PhylomeDB" id="B0XM08"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000670">
        <property type="entry name" value="Vacuole-associated enzyme activator complex component (Vac14), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="7">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="9">
        <location>
            <begin position="595"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="824"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="835"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="927" mass="103234" checksum="4788BEFD41DAE7B6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM38</accession>
    <name>B0XM38_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_000790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000790"/>
    <dbReference type="HOGENOM" id="CLU_087059_3_0_1"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="PhylomeDB" id="B0XM38"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="241" mass="27440" checksum="5A0BBAA914803709" modified="2008-04-08" version="1">MDGWSDLSSAPPQYREVAGIADWALLAQGLGWSINYLAMIYHSYKDRTYGMAILPLCCNFAWEFVYSVIYPSHNSAERAVLTTWMILNLFVMYTAIKFAPNEWQHAPLVRQCLPWIFPVAIAAFTAGHLALAATVGVSKAANWGAFLCFELLTSGAVCQLMSRGSSRGASYTIWLSRFLGSYIGGIFLHVRETHWPQEFGWISHPFVTWHGLMCFSLDIAYVTFLWRIRRQEHRSQRKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM77</accession>
    <name>B0XM77_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_001260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001260"/>
    <dbReference type="HOGENOM" id="CLU_019582_2_2_1"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="PhylomeDB" id="B0XM77"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="515" mass="58918" checksum="D22C81062758BDC8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMF5</accession>
    <name>B0XMF5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-amino acid oxidase, putative</fullName>
            <ecNumber evidence="8">1.4.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_000070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="8"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000070"/>
    <dbReference type="HOGENOM" id="CLU_034311_3_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="PhylomeDB" id="B0XMF5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="331" mass="36677" checksum="8E25C4E2BFF22F60" modified="2008-04-08" version="1">MEIGIIGAGVVGLTSALALVEASYSVTVVARELPGDNSQNWASPWAGAGILPHPDSEGHELQAESFKYYWALAHRDPTSGVQVVDVIEYYDDRVDDSTIWYKRLVPKYRRLPATDLPAGAKIGFTYQSMTVNPAAFLPWIKRLLDSKGVQFVRAEVKSLIEAQRMLGIKIIVNASGMGALDLAGDKEVVAVRGQTMLVPSDSLEMIMFQGSHYTYQIPRMYSGGVIIGGVSQEGNYDRTATPELREDILRRVNLVTKDRFQSVDVDRDIIQDLVGFRPGRRGGYRLEREGNVIHAYGFNTLGYTYSYGVAMKVLEIVQRMGNGRSSFKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNH4</accession>
    <name>B0XNH4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_015160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015160"/>
    <dbReference type="HOGENOM" id="CLU_2637620_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="77" mass="8190" checksum="36202D3E2F068B70" modified="2008-04-08" version="1">MLLGSGGGWLACLNAWILQNQNHLSQSQSGLSPSLDNDLDLYNPQAFNPVTSLILSLIICGSDCLLITPLAESTQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNP6</accession>
    <name>B0XNP6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NifU-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_005020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005020"/>
    <dbReference type="HOGENOM" id="CLU_060555_0_0_1"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="PhylomeDB" id="B0XNP6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="87"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="326" mass="35803" checksum="CBB6B68C4CBDFAD2" modified="2008-04-08" version="1">MSVSRTSTTLLRRALLDSRFSPQSATIQSQGIRPALGSYNSIHNSARLPAITASGTRRRPTLRPHQRPAAQARVNGPLPVTRRTIFIQTENTPNPDALKFIPNHRVLPEGFPTSFLEYLSPRSTLAPPHPSPLAANLFNVDGVTSVFYGPDFITVNKSSDANWAHIKPEVFSLITQAVTSGEAIVNTVEKTGEHAQESGEQESLSFSEEDDEVVSMIKELLETRIRPAIQEDGGDIELRGFENGIVKLKLRGACRTCDSSTVTLKNGIESMLMHYIEEVQGVEQVLDEEEEISMHEFAKFEEKLRQQKGPQATASTGGKGTLDTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNV3</accession>
    <name>B0XNV3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_015780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015780"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="PhylomeDB" id="B0XNV3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003119">
        <property type="entry name" value="ABC ATPase, putative (AFU_orthologue AFUA_1G16440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="59"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="526"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="779" mass="87325" checksum="1D3FD3AF86DF26DA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP46</accession>
    <name>B0XP46_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_005890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005890"/>
    <dbReference type="HOGENOM" id="CLU_021861_1_0_1"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="PhylomeDB" id="B0XP46"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758209" description="HTH CENPB-type domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="403" mass="43932" checksum="AABC133D66CA7999" modified="2008-04-08" version="1">MWVTSILTLAFTFQSTVSKVLRQKEKYLNPDEGSRSPIKRAKGRVPDIEKALSNWVRNYQKQGYPLSDEMIREKALFFASTCGSPDGKEKVLTQSWLEKFKLKNNLMGAKSRKGSFAKSDSESPTRLTIDSALASAVQSPSVLSPTSPTGFASPSPLSPIMNPEHMRKELAKSLDELAEEYQHKHAKSTTSLDTNCSLSASVTSPTSTLVSDSPFTPVSQSRGSLADSQSNRPRSQTLPTGTLDPSLISTEESSDHSLSKAALQQSLSITTLESPLEDEHNSKKGPGLDTSSNTIKRNRSNPEIKAKPMYPPSFSKSTTVSPISSPGSPTQDEARRALELVVSYFEHQPTGLGAQEFVTIGKLMERLELARAQQTALPGGLARIDELEDAPQLTKKRSIHNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPC6</accession>
    <name>B0XPC6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-lactate dehydrogenase (Cytochrome), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_016870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016870"/>
    <dbReference type="HOGENOM" id="CLU_017779_3_2_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="PhylomeDB" id="B0XPC6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF83">
        <property type="entry name" value="DEHYDROGENASE (CYTOCHROME), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="574" mass="62315" checksum="846350E73788E9AB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ44</accession>
    <name>B0XQ44_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SNF7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_008640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008640"/>
    <dbReference type="HOGENOM" id="CLU_086201_0_1_1"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ44"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760380" evidence="9">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="217" mass="24680" checksum="5425CC1F5D7E1862" modified="2008-04-08" version="1">MPRKWGTQAVLIKSLLRIELLVLRAILDLKNQRDKLRQYQKRITVLTDRETAIARECLARDDRRRALLALRRKKYQETLLSKTDAQLEQLEHLTSQVEFSLVQKDVLFGLQQGTKVLQAINKEMGGIEAVEKLMGETEEARAYQEEISQMLAGQLSNQDEDEVENELERLRQETEAITLPNVPTAPPVMAVGEEEADTEEVEISAARTKTRTAVPAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ55</accession>
    <name>EIF3F_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="1">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AFUB_008750</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ55"/>
    <dbReference type="SMR" id="B0XQ55"/>
    <dbReference type="EnsemblFungi" id="EDP56169">
        <property type="protein sequence ID" value="EDP56169"/>
        <property type="gene ID" value="AFUB_008750"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008750"/>
    <dbReference type="HOGENOM" id="CLU_027018_0_0_1"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ55"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000364322" description="Eukaryotic translation initiation factor 3 subunit F">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="345" mass="37199" checksum="92250506F85EFA6D" modified="2008-04-08" version="1">MAETDSFLHLARPLGPVAVGSAPTTAPLNVVIQPQAIFSILDHSLRRNADQERVIGTLLGTRSEDGTEVEIRSTFAVGHTETTDQVEVDMEYQKQMLALHLKANPKEVLVGWYATSSELNTFSALIQNFYSGQGDGTWPHPAVHLTVSTEPGKDIETRAYISAPVGVTAERAADSAAFIPVPYEIRYGEAEKSGLEAIASAKDAESRATNIFTDIEALERAIEEVLGMIDRVSRYVESVIDEEAPASTALGQFLLNALALAPKVEPADIERDFNNHIQDVLVVSYLANTIRTQMELSNRLATAQLTLGGEGASAEAGAQRGQRGGKGGRGGQQRTQERASEEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQD0</accession>
    <name>B0XQD0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM-barrel enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_009520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009520"/>
    <dbReference type="HOGENOM" id="CLU_058589_0_0_1"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="PhylomeDB" id="B0XQD0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="9"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="279" mass="30053" checksum="4EE21F2AB81C8B65" modified="2008-04-08" version="1">MPRPTTRQEVLARLRQTIAEGSIIVGAGAGIGLSAKFIEKGGADLILVYNSGRFRMAGRGSLAGMMPYSDANQVVVEMANEVLPVVEHTPVLAGVCGTDPFREMRSFLAQLRGLGFIGVQNFPTVGLIDGKFRQNLEETGMGYDREVEMIRLAHEMDLVTTPYVFTVDEGERMARAGADVIVVHVGLTTSGTIGAQTALSLDECVGVVQAIRDAVVRVNPEVIVLCHGGPLAGPEDAEYVLSRTRGVHGFFGASSMERLPVELAIQENAQAFKRLKIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQJ0</accession>
    <name>B0XQJ0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_010130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 9">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQJ0"/>
    <dbReference type="SMR" id="B0XQJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010130"/>
    <dbReference type="HOGENOM" id="CLU_000288_72_2_1"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="PhylomeDB" id="B0XQJ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="453" mass="49448" checksum="464FEAE5FCCE007B" modified="2008-04-08" version="1">MDVFPSTTPDEAVRKSAKRTAELFGSEYLLVTPSVADGSIGLSYRKKAEYSDVKELPPALAEKQAKAAAAGRAKRPKIQPQTKPQADGSGASMSLVKRAAGPAAGGVGGEGQPKSLIQRPSATRQQRPDWHPPWKLMRVISGHLGWVRSLAVEPNNEWFASGAGDRTIKIWNLATGALRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLALHPRLDLLVTGGRDGVARVWDMRTRSNIHVLSGHKGTVADLKCQEADPQIITGSLDATVRLWDLAAGKTMGVLTHHKKGVRNLAIHPREFTFASASTGSIKQWKCPEGDFMQNFEGHNAVINSLAVNEDNVLFSGGDNGSMCFWDWKTGYKFQSIDTMAQPGSLDAEAGIMSATFDRTGLRLITGEADKTIKVWKPDDEATPESHPVTWAPTLGRQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQP6</accession>
    <name>B0XQP6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_010700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010700"/>
    <dbReference type="HOGENOM" id="CLU_020986_0_0_1"/>
    <dbReference type="OrthoDB" id="3590765at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758244" evidence="1">
        <location>
            <begin position="27"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="535" mass="57560" checksum="E6640ED4220718D2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQR0</accession>
    <name>B0XQR0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin conjugating enzyme E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_010840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010840"/>
    <dbReference type="HOGENOM" id="CLU_030988_0_0_1"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000077">
        <property type="entry name" value="Ubiquitin conjugating enzyme E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="391" mass="42266" checksum="E0695EA57839DE46" modified="2008-04-08" version="1" fragment="single">RSSFRRLAADHAALHEELPPNYLFPTEESSDDLTQLTTLLAGPQGTPYSQGLWRLHLKMPEDYPKSPPKATFKTRIWHPNVEESTGAVCVDTLKRDWKSTLTLKDVLVTISCLLIYPNPDSALNSTAGALLQEDYDAFARQAKLMTSIHAPVPPDLRNAVVEAKSRGEEPGTLIPEHEGARSTQNQTMTATPPGPPPPKKNDPSLSPSPVKLAPPSPRKNSHGKRPLSDLTTSLDPEPDSLIDPDLASSRTLDKVTMTMTASEKNVAANHPTHRGSSPQPPPQRKSPKLSLLDKGINTSARIRDDVIIIFEDASDPSDLQSNDSKENHAALHASKGMGPSARKSPHYPTSLLAPSTAVTCPSGSKSRAVSGSRKASSSSMKAKPRIGIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQR4</accession>
    <name>B0XQR4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin class II heavy chain (MHC), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_010880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010880"/>
    <dbReference type="HOGENOM" id="CLU_001004_0_0_1"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="PhylomeDB" id="B0XQR4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="643"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="786"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1787"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1956"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1471"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1828"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="889"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="915"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1958"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1983"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2009"/>
            <end position="2028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2089" mass="230989" checksum="5F298DD284E14452" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQU1</accession>
    <name>B0XQU1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_011150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011150"/>
    <dbReference type="HOGENOM" id="CLU_823806_0_0_1"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="290" mass="31598" checksum="4DD98D071D5816F0" modified="2008-04-08" version="1">MPTWSGIVQIPGVMGGTMTHAITFTVQQETEKPLASFRLLIGLSILTCNRTMRTMITSMGRCNAHTIAYMVMLMPLKQCLTRDVHQDSSSSEKILQPTAIDIALKLVRGARQLRDSMLPLHANLYSAPSTIFNTAVSPCSAIIRDQGRCLMQRDEAIEAISATLGTLEQISHSTKTAATCYLVLSKLVNKLSLASEEELILRSESSDSPLRGRGVKAPCDSQLTLDAHLQLVDGHSSEMYISTMPGCPSLEPLTPPSSDPQELFNVDLGELGQIWDLKNLGLDFPQALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR05</accession>
    <name>B0XR05_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_011800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001442_1_3_1"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="PhylomeDB" id="B0XR05"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000024">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000047">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="DUF7072"/>
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        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23258">
        <property type="entry name" value="DUF7072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="345"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="588"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="957"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1433" mass="159104" checksum="2F9AC8696A85127B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR34</accession>
    <name>B0XR34_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS toxin efflux pump (AflT), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_012090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
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    <dbReference type="EMBL" id="DS499594">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012090"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B0XR34"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="551" mass="58789" checksum="B9907044AD2DDD91" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR98</accession>
    <name>B0XR98_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_012600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012600"/>
    <dbReference type="HOGENOM" id="CLU_1805727_0_0_1"/>
    <dbReference type="OrthoDB" id="4526693at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="143" mass="16842" checksum="69C3A7100D692AF1" modified="2008-04-08" version="1">MTCIVGLARLIRRRRQGQCGLPMSKMDTHFTRQEKYDREQQTKELQQRSYLRGTSPIAMNIAQRRRIEMLAWSTHSLRPVLEKKVRINTGTMFQYLLHGLLRLTDRKSMSCQAPKNFIHRRDEIKQSTFLRLWMQKAPVPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRR2</accession>
    <name>B0XRR2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">20S cyclosome subunit (BimA/Nuc2/Cdc27), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_024540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024540"/>
    <dbReference type="HOGENOM" id="CLU_008850_0_1_1"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="PhylomeDB" id="B0XRR2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051728">
        <property type="term" value="P:cell cycle switching, mitotic to meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="618"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="652"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="754"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="809" mass="89673" checksum="972779844F6B97E7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRV7</accession>
    <name>B0XRV7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_024990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024990"/>
    <dbReference type="HOGENOM" id="CLU_014801_3_1_1"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="PhylomeDB" id="B0XRV7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="727" mass="78921" checksum="CCD27030A57E61C8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSC3</accession>
    <name>B0XSC3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS9 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_026680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026680"/>
    <dbReference type="HOGENOM" id="CLU_017705_0_0_1"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="PhylomeDB" id="B0XSC3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="244"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="739" mass="80045" checksum="9B205A555037F538" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSQ5</accession>
    <name>B0XSQ5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_017230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017230"/>
    <dbReference type="HOGENOM" id="CLU_050461_0_0_1"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="PhylomeDB" id="B0XSQ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF6">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="279" mass="30424" checksum="CD063C4FF88F7C7C" modified="2008-04-08" version="1">MAALATNTSISQGFYKPEENVFCNDGREDQLLHFITTHPQLSAIRNSPEAVLAAVDEFARTKDFLMNVGPYKGGIITDIIATEQPSSILEIGGYIGYSAIMFGSAMRNTGVLAPRYVSLEMNPKFASVSRTLVEVAGLSDVVEIQEGPCRKSLHRLAAGTSNKGPSSKKWDILFLDHSKISYLNDLKLAEELGIVAPGSIVIADDMKRPGNPMYSDYVMADTATKTEAYMPFVGCLSDGGISLGNPYLMYQTVLLEGLEPTGHMVSFYYPRLLRFAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSV4</accession>
    <name>B0XSV4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_017740</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSV4"/>
    <dbReference type="SMR" id="B0XSV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017740"/>
    <dbReference type="HOGENOM" id="CLU_003731_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="B0XSV4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="560"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="948"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="916"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP53731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118156" checksum="B4251B05055AEAEE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT06</accession>
    <name>B0XT06_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_028440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028440"/>
    <dbReference type="HOGENOM" id="CLU_1434142_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="189" mass="21583" checksum="4C80E6DEC2095B94" modified="2008-04-08" version="1">MTWAYPLPSHVSKESLPLRRRLFHLVALTAQEKSRINLLDVVREVEWSMREDNIAEQQELKRHGSDVLGHPQSPRPGQCPCCAFRRYYVFYLALLWHPTNVRRDNLLVRVCGNGHGRPADIGYLFLDKPYPVVMVIPLTEIDRDDKIYHQSAYPFTIPLHAAASARGITKLCQNLDTSLRGEAPAARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT66</accession>
    <name>B0XT66_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_018190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT66"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018190"/>
    <dbReference type="HOGENOM" id="CLU_026784_0_0_1"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="491" mass="56815" checksum="D4974B1E3BDC9385" modified="2008-04-08" version="1">MSGSKKGGKSLCQLPENAKLRILEYLGLVRPCLIDITGEAHRVKQAADHTCDTRNLFHTRGNWSTRAGQVCDHPRLPTEVLMVSRKFREDLGALFWSHNRFSFILTNLNDWDCFFNAVDWAAEDVRYLYIEMRTWDNRFIKPGGQRNLLRLWSRFCRYAALEMVNLRYFSLKCRVKDMAVAVKIMSAMDPFPVLSECAFHFSHTPEEAIRPVVKSNALRLTGNLSEDCTIPFPYFDLPKEVQLIILEFLLGNQLDPYLPPEGRLPGVISFMDRKSLRINESRPLTCCGTCSSLKAACFCRARQTAYSTTCSCFSSPVSYFLVCRAFYEDARRIFFTINRFAFVEEDPDFMMGFMNSIPTSSFMLICHLVFKFPAMHRHPAKPSHKPHEDSAMVSWSVLRRFIREHFELSRLSLTIVDLGTKESSWQNAATHRNKYVRKLLEAFQDLRGLREFRVFLEDDQSYELTAEQLVMGRAVASRPLDFQFPFVENGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTH7</accession>
    <name>B0XTH7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_018620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018620"/>
    <dbReference type="HOGENOM" id="CLU_016578_0_0_1"/>
    <dbReference type="OrthoDB" id="5413982at2759"/>
    <dbReference type="PhylomeDB" id="B0XTH7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="74565" checksum="A2FC99D574422021" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTL0</accession>
    <name>B0XTL0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low molecular weight phosphotyrosine protein phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_018970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018970"/>
    <dbReference type="HOGENOM" id="CLU_668977_0_0_1"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000317">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="5">
        <location>
            <begin position="224"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="411" mass="45548" checksum="E19A3BF2986E31C2" modified="2008-04-08" version="1">MYYAAAEHCFACNIPHLDNRKNELQFINQAVDIGALVHGLQWRDLGVVLGYWANGKPICLSLPQCHTPNMSALWLSPLKITLRRKGTNITSCIEEFYLLRLRFGKIPYLFQHNHIFFLSSVLGISIFHGYIRDNLIAPYQQKSSSYHAVAGALFVELVDVPEECLVAEGGATWQNSYRCGGVCNILIGDAYMHLSQCLFNHQAASQQTTIAMTASESPSAEHKVNVLFVCLGNICRSTMAEGVFRNMASTHPLINEIDSAGTGAYHTLEPPDSRTMSTLRRHGITNYNHAARKITKDDFLHFDYLLAMDKYNLRDLLDVRESVVASLRKSGGAKGPRASSGGAGAKVAEVRLFGDFGPGGVLHDRVGGGEVVQDPYYGGVNGFEEVYQQVVRFSKSFLEYLEKKQGSEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTP6</accession>
    <name>B0XTP6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_029470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTP6"/>
    <dbReference type="HOGENOM" id="CLU_2196342_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="108" mass="12170" checksum="67F7166B1013E438" modified="2008-04-08" version="1">MPKIKERASYLWQLTGLISMIASAHLDLKNFDPGSICYCNVFFSSLLLLSLGILVGRGFDKRSTAPEERQFWKSTYSGVPLAQAQMSEIGDTSSVTCTWKIYSVVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUA8</accession>
    <name>B0XUA8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYB DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_020080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020080"/>
    <dbReference type="HOGENOM" id="CLU_039317_1_1_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="241"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="298"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="341" mass="38040" checksum="2EE0DBAB12D97735" modified="2008-04-08" version="1">MSVTLADPYRDYALDYAQHAKPEGHENALAYQTQHSHLQRHKEANPPFPQGSPHNTAYEQHHASTTVLPAANPDISQSVVLTAAHMLPRQLPMQYTPTTFEIPPVQRGKKRPHSEAEGEGDYGDHGVRPRLSALPTQASTETAQSPGMLFSVQGDSSQQQAHHQQQQRPPQQHHHHQPMPSHGFGPPESMALPQQHHHHRLPPQASLHSAERHGMNAETSPIPSGLPSVVGQPGMPDPAPRPRGPKLKFTQEEDALLVELKENKNLTWKQIADFFPGRTSGTLQVRYCTKLKAKDVTWTDEMVQRLQRAIQEYENDRWRIVAGKVGNGFTPAACREKASQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUS0</accession>
    <name>B0XUS0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,3-glucanase/mutanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_021050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021050"/>
    <dbReference type="HOGENOM" id="CLU_019141_0_1_1"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="PhylomeDB" id="B0XUS0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758364" evidence="1">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="496" mass="53977" checksum="A3FBA1E8A9250A94" modified="2008-04-08" version="1">MILLKSLSFALAGLSALATAIPMPKPFSADVSTEVSSTDRLVFCHFMIGITSNRQSAADYDDDMQRAKALGIDAFALNIGVDPYTDTQLNFAYESAARNDMKVFISFDFNWYNTGQATAVGQKIRQYASLPAQLKVDGKVFASSFAGDGLDIPALNSAAGTEVFFAPNFHPGVGDFNAIQGALNWMAWPNNDNNKAPTPDHNVSVAEGDSKYIAALNGKPYIAPVSGWFSTHFGGEVPYSKNWVFPSDLLWYDRWQEILNLGPRFIEIVTWNDYGESHYIGPLSSPHTDDGASKWVMDMPHNGWLEMSKPFIAAYKAGEKSANNYITEDKLIYWYRPTPKDINCDSTDTTMQGNPNNSSGNFFRGRPNGYESMTDEVFVVSLLKSPATVQVTSGSSSKTFQAQAGASAFSAPMGVGKQQFSLLRNGQTVMSDTSLKDIVDSCICGIYNFNAYVGTVPPEKTIDKLQPAGLSMLYQGLTVPCPTNTLGLSSPTATAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUW2</accession>
    <name>B0XUW2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleotide binding protein Nbp35, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="11" type="ORF">AFUB_031640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUW2"/>
    <dbReference type="SMR" id="B0XUW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031640"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="PhylomeDB" id="B0XUW2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="345" mass="36712" checksum="5D7A2E08C98220E8" modified="2008-04-08" version="1">MAPSVMEPVAAFDVPTKAAPNLVAPEPEHCPGPESEQAGKGDACAGCPNQAICASAPKGPDPDIPIITERLSQIRHKILVLSGKGGVGKSTFSSLLAHAFASNPESTVGLCDTDICGPSIPKMMGVESETIHVSNAGWSPVWVTDNLSVMSIQFMLPNRDDAIIWRGPKKNGMIKQFLKDVDWGDLDYLIVDTPPGTSDEHLSVNSLLKESGVDGAVIVTTPQEVSLLDVRKEIDFCRKAGIRILGLVENMRGFVCPGCSNTSEIFRATTGGGKRLAKKMGIPFLGSVPLDPRVGMACDYGESFVDNFPDSPASKAIKQVVRSVGEMLGEDPNTVLPPDENDMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV18</accession>
    <name>B0XV18_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparaginase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_021340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021340"/>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_1"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="PhylomeDB" id="B0XV18"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000008">
        <property type="entry name" value="N-terminal nucleophile aminohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="461" mass="49984" checksum="56AD42DC49EA2083" modified="2008-04-08" version="1">MTDSIPATFKPALIIHGGAGNIQRSRLPPDLYAQYHASLLSYLRSTKDLLNSGASALDAAVHAVSLLEDDEFFNCGRGSVFTSAGTIEMEASVMVTTVNKPTDETPSPIKRGAAVMELRNVQHPIQLARECLLRTGHDANGNPNGDGGNMHSQLGAPYVEELARAWGLEFKPDEWFWTKRRWEEHQRGLKGETEPVSLSQGTVGCVCLDRWGELAVATSTGGLTNKLPGRIGDTPTLGAGFWAEAWEEGLREAGGKRMVYRSSMSDPNDAEDTSWGTAAIKRMVAECMPPVVNRLLWPATDTRLPSQEHSSEKQALLEQEGLPRRIKRRAVALSGTGNGDSFLRVAAARTACAMLRYSQASVPRSLAEAVSAVAGPDGELQRSAGRRWGKTGEGEAGIIGIEAETVLDATGAGLRAAQKKTLSRGKVVFDFNCGGMWRAWVEEDATGKDVERVMVFREEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVB3</accession>
    <name>B0XVB3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SWI-SNF complex subunit (Snf5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_032510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032510"/>
    <dbReference type="HOGENOM" id="CLU_018784_0_0_1"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="PhylomeDB" id="B0XVB3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="803" mass="88907" checksum="B998C44842968838" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVI9</accession>
    <name>B0XVI9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_022410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022410"/>
    <dbReference type="HOGENOM" id="CLU_011910_0_0_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="B0XVI9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="763" mass="86036" checksum="368A898961E88CEF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVP2</accession>
    <name>B0XVP2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-PSP endoribonuclease family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_033140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033140"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="PhylomeDB" id="B0XVP2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF48">
        <property type="entry name" value="2-AMINOMUCONATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="150" mass="16303" checksum="57ABA00501FDA9ED" modified="2008-04-08" version="1">MSNGTPYFLPAEKAQGLANYPHARFAPTTAHRTLYVSGTSSRRGDGTWDGVTEHADGTWTLDIRAQTAAVLRNIEGIIHGATHGRGGLQNIVDATVFLIDLPQNYAGMNEEWNKVWPDRANAPARTTIGVKELPNPRLLVEIKCTAVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVS5</accession>
    <name>B0XVS5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">mRNA decapping hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_022600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022600"/>
    <dbReference type="HOGENOM" id="CLU_041045_0_0_1"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="PhylomeDB" id="B0XVS5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.40:FF:000004">
        <property type="entry name" value="mRNA decapping hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000016">
        <property type="entry name" value="Scavenger mRNA decapping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="328" mass="37691" checksum="3F374808A433CB57" modified="2008-04-08" version="1">MQILDSGEKITPEALIPKFEVNRLLKQDQNGRRIAILGYIDGKQGILIAERAAFATESLEVLKAFHAAISSVDNLGDNDIYRWYLANTGAGQGGQQFHDLKLNLIWPCTEKHIKKYSDQQLRMVTETPEIYRDYVRPYMSAQREEGRLNWVFNILEGRTEQEDVILRDAGEGPDDGFLMLPDLNWDRKTMSSLHLLALVQRRDIWSLRDLKKKHIPWLRYLRQRLLEGTVKMYPELEQDQLKLYVHYQPTYYHFHIHVVNVMLEAGATQATGKAFGLENLISQLETLAGDQDASMADVSLTYYLGEASDLWMNIFYPLKSGSKPAIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWN0</accession>
    <name>B0XWN0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_046680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046680"/>
    <dbReference type="HOGENOM" id="CLU_3068215_0_0_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="53" mass="6201" checksum="3FAC3C6B34C8956E" modified="2008-04-08" version="1">MEHLNCRGPQRPAYGILAIGRRVMQPVVREEFASKTMITVAHRLRTILVVIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWP1</accession>
    <name>B0XWP1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_046790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046790"/>
    <dbReference type="HOGENOM" id="CLU_912080_0_0_1"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34068" checksum="A7115922F05A4706" modified="2008-04-08" version="1">MYFVIVADCRCRLNAAAVSCSQAMALETDGAMSKTMEGEPYKNFRSVKMAGFASAPYNSISPHKSVQRSLYRNLEMASKLYKISPASLKYLETPELWKIIESDGELAPHANHIVQQRFMDNNIYTVPSAEAFKNLTDHSSDPIDDIIRYDRVKTLKCLVDAGLNLQHYSRSGWMLLGLALATKTDRISRYLIDASFPKDICGRIGALNDCEDGTFLSVAATWDAFVHGASGETAWHAAAECATDLEFPRWIGVQAPETINERTVHGTTPLMKAAACNRFPRLLSFFSRMVLVQRLSMMRVILRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX37</accession>
    <name>B0XX37_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, 2OG-Fe(II) oxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_047610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047610"/>
    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="PhylomeDB" id="B0XX37"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000093">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="337" mass="39301" checksum="E9F83D10B3AD0977" modified="2008-04-08" version="1">MATQTTQLNFPLAASTEPLEQYVHPPETKQDSFFYVTNFGLTQEQVDRQFAIAKEFFSLPEEERRSFRAPLEEGIYNGYRPLGSIEILPGLRDNIEFYNIMKFLPQYERTHPDVIRRHWAEIEKFHRHVHEHIAYRLFRLLAIVLEIPEDELEKGHLYDSNCDSGLRYMCYRARSAEENEKYKSLYSRGHTDNGTITFVFQQPVAGLQVKKHDDSEWEYLRIPSGTIAVNIADLLSILSNGYLKSGVHRVITPPKDQQHLDRLGVLYFVRPSDRLTLRTVDSPLLRRLGYYKEGITEINIPAPEWTRARIKKNWTRSPTDPNEGTSMAGFSVKHFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYC1</accession>
    <name>B0XYC1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_040380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYC1"/>
    <dbReference type="HOGENOM" id="CLU_030043_0_0_1"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="521" mass="58374" checksum="08ECF1983017281F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYU6</accession>
    <name>B0XYU6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_042130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042130"/>
    <dbReference type="HOGENOM" id="CLU_002305_2_0_1"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="PhylomeDB" id="B0XYU6"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
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        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="752"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1185"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1164"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1703"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1164"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1796" mass="205660" checksum="030029371924A159" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ07</accession>
    <name>B0XZ07_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_042740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042740"/>
    <dbReference type="HOGENOM" id="CLU_057568_0_0_1"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ07"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34853" checksum="AD104809A24B0B29" modified="2008-04-08" version="1">MSDTLPNPSGLSAKVNKKRKRQAEEAPKEDKAASAKSANNNTLEAAEGPLKKKKKRNFKNKQKQQKKKDLEDDPKQQERKGGIDESIGKMDGRLLADYFVQKAKRHNKELTAVELGDLSVPDSAFLDTSSFESPRSLDQLPAFLKAFSPDKGSGLSKASEQKGTPHTLVVCPAALRAADVVRWVDQTYIAVLGWRLIRCSRALRAFQSKDSTVGKLFAKHIKLEEAKQFLQRARISLGVGTPARILDLIDAGSLKLDELERIVIDGSYIDQKQRGIFDMKETHIPLLQLLTRSEFRERYGAKQKRIQVLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0K3</accession>
    <name>B0Y0K3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor histidine kinase/response regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_057620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0K3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057620"/>
    <dbReference type="HOGENOM" id="CLU_1517537_0_0_1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="177" mass="20580" checksum="4891C42ECAFCF176" modified="2008-04-08" version="1">MLPTGVAIRNHRDEAIFANHRFRNLMTKRDLRSFDCWPQSVHPDEYDRLATAYHDASRAQQPLCIQYRTRDDDSRPLRPHQRRRRHLHYRRHHPGKDRRAFPAANRRGSSAAQDPAGAVHRHDQPRSTEPALRHPALHRGHSQRGAPDPERGRARRRRRMRRLSVGGCVISTGARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0S1</accession>
    <name>B0Y0S1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_058330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0S1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058330"/>
    <dbReference type="HOGENOM" id="CLU_055856_0_0_1"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="166"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="267" mass="28762" checksum="9BAC74DDA821189E" modified="2008-04-08" version="1">MSSNDPHPPPSDIASPGIKDEAASVTLGSPQEPQQQSQTPAGSFSEPVENAAVPATQSGAVNTQKYDNADSTQAAGVHDSSTPIVAAEQSIRDTFATNDKPQDTTGLESTDTPVPEPLPDASDAAAKEVEGSAPSLTITLLLTTGSRHPFEIDGKYLQKRGINVESNDPFAMSVYTLKELIWKEWRQDWESQPTSPSSIRLISFGKLLDDKSPLSDCKFNKDAPNVVHMTVKPQEIVDEEDAKAAKAPYSREREASERSPGCRCIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0V8</accession>
    <name>B0Y0V8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_058700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0V8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058700"/>
    <dbReference type="HOGENOM" id="CLU_040685_0_0_1"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0V8"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001872">
        <property type="entry name" value="PAXNEB protein superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="393" mass="42500" checksum="E982D746241A024A" modified="2008-04-08" version="1">MSFRKRNIGLSGTVDRTPIANTSAQAPQATTTTESHPGIRPSPDDGRPTTSTGTRSLDNLLAGHGGLPIGKILLIEENGTTDFAGALLRYYAAEGVVQDQKVHVIGMPEQWGRSLPGLIGPADMLDEKSDKKKSERMKIAWRYERLGEFGAGVAGSRAPAVSGEQSPTAADMNKQEAFCHAFDLTKRLTHPSISNLTYIPLTPSNEPLFISIYKRLQTAIASSHPSTVHRVVIPSLLNPTIYPSEVSQPDHVLPFLHALRALMNTQGHRITAMITVPLSLFPRSSGLVRWMEIISDGVIELCPFPHSADALATSGAATSQEEPPQGMLKTHKLPVLHERGGGSDQNVGQDWAFTLSRRRFEIKPFSLPPAEGDKEAQDAAGPGGMPKKADLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y138</accession>
    <name>B0Y138_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">U1 small nuclear ribonucleoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_059490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y138"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059490"/>
    <dbReference type="HOGENOM" id="CLU_041869_0_1_1"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="PhylomeDB" id="B0Y138"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="180"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="255" mass="28249" checksum="BBA9FBC875930106" modified="2008-04-08" version="1">MCVSSSACYNERTAHLTSLTKQVRNLEERIKVDQLKVALEEIFSEYGNIVEIVAKTNLKAKGQAFIVFDNVESATRAIEEVNGFELFDKPMVLDYAKTKSDATVLREGGTEELEVHKRRRLAEKERKQAHEALEAQKKLKRPPGPADTARPAKTVKGAGLKPTSGAAAAVIPDEYLPPNKILFLRDLPDTADQESLTAIFGRFEGFQEVRLVPGRKGIAFVEYENESGAISAKEATANMPMGDNGKPIRVTYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y170</accession>
    <name>B0Y170_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_048890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y170"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048890"/>
    <dbReference type="HOGENOM" id="CLU_038300_0_0_1"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF44">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="58604" checksum="A38197ECC8882B32" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1H2</accession>
    <name>B0Y1H2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">AFUB_060320</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_8_2_1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1H2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000025">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="24">
        <location>
            <begin position="1740"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="23">
        <location>
            <begin position="2441"/>
            <end position="2772"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="25">
        <location>
            <begin position="2783"/>
            <end position="2815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="2743"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="2176"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EDP52002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2815" mass="317343" checksum="B52D15BFF3C33AFA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y212</accession>
    <name>B0Y212_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde reductase (GliO), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_050540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y212"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050540"/>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B0Y212"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="320" mass="35507" checksum="F1F24431D1F20EA2" modified="2008-04-08" version="1">MANSHAQIIFGGAIFGTLPEWSTPEKVEEFLQVLERNNVKTIDTAQIYSASEENLGQVKAAKRFIIDTKLGGGFAPGSATKDQAIKTGDESLAKLGTDSVNVYYIHSPDRQIPLEETLAGINELHKAGKFKHFGLSNFRPEEVQEVVRIAKEKGYVLPSVYQGNYNAVARRIEAELLPVLRENNIRFYAYSPIAGGFLTKTKEQLLAGGEGRWDPNSAIGQIYHRLYNKPAMLEVLDDWAEIAKAEGVTKAELAYRWIFFHSHIREDLGDAVIVGATKISQFEETIAAIQRGPLSADAVKRIDAVWEKIKDVATLDNFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y221</accession>
    <name>B0Y221_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_050630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y221"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050630"/>
    <dbReference type="HOGENOM" id="CLU_050894_0_0_1"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="265" mass="29461" checksum="0A4BE6B6C7FEAC75" modified="2008-04-08" version="1">MSKLLSQGGVELADRYAPLWFFGQAQKQPPCYPTWAFGGSPTSSDIYDDAHKTPPAPQCEYPNVGCRCRNPGVGIGNRGPPFPIYFTYKRCSDTEVRVVYNLFYEKDGADVIGIETGHDYDWERVIIIHSRDANNMWAPTRALLSAHSGYHDLAWGDIQNTLTTDEINAGDAKNPNGVQNNDHPKVYVAWSKHAHFDDRNTGWNDPISQSTDNAFRSDDWWYYVDKSYYILSDDTTAAGKALGSANWGDATSNPPSVHASVCSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y295</accession>
    <name>B0Y295_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho GTPase Rho4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_061740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y295"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061740"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_1_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="B0Y295"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="286" mass="31429" checksum="AE084F766A0CD7B4" modified="2008-04-08" version="1">MSGHMYEDSGYAASRRRSIATPPPSMTPRHNRTRSQSVRVSNGTVSTNTSVSSGRMSEATNITQPPAYSKKFVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYITQTTHRASGKTVELALWDTAGQEEYDRLRPLSYPETDLLFVCFAIDCPASLENVMDKWYPEVLHFCPTTPIILVGLKSDLRTKRTCIELLKTQGLTPVTPEQGETVARRMNASYIECSSKEMRGVDEVFALAVDTVVSAEEQDWMGNSQSNGTSSKFGGGGSGLRSGSKKVKKRTCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y313</accession>
    <name>B0Y313_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_052580</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y313"/>
    <dbReference type="HOGENOM" id="CLU_037229_0_0_1"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="PhylomeDB" id="B0Y313"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000781">
        <property type="entry name" value="Meiotic recombination protein spo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="14">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="15">
        <location>
            <begin position="202"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP51254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="381" mass="42760" checksum="FCF8511FFB50A93D" modified="2008-04-08" version="1">MYRHIVVDNEQNREAMENAPDNAGSSPARFFTNQEQSQKERVQTFIDNILIEILDELRTPDGRPTLTLKRRSRGVPRSINPENLALESEEKEILSSYSWPGTNAYEAWKFTAIIRGLSVIAEAIQAGLVVSKRDIYYSDPACFGSQQIVDTIIDDIAHTIGVDRAALNVEAVAKGLVAGYYRLMTKTGEMVDARLSTKVVKWVLILEKEAVYRRLSRSSYHTRAAAGKGVLGKGYPDLSTRAFVRRLLDETRHLPAEESPRFYALVDSDPDGMAIMSTYKYGSMAHAHDNEKLNVSKLCWLGLRTSDVIGGADSFGDEAFIRLSLRDRKKAVAMLSNNPVWAEDGPEQEWRAELQQMLMLNLGLRFSTIGRKDLKGGSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y386</accession>
    <name>B0Y386_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_053310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y386"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053310"/>
    <dbReference type="HOGENOM" id="CLU_072378_0_0_1"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="PhylomeDB" id="B0Y386"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="243" mass="27196" checksum="74EAF22A37C526FA" modified="2008-04-08" version="1">MNQDSEQKHQPARDLDDDNDDDSLFEALENEDDSAYRAHRIEQLNAEFSAAKNNRSSLHDLATTVIEEGIYPTLKDDQAVLDFTTQTHRCVIHFAHPDFARCGVMDEHIRALATRHHEVRFARVDVRNTPFVVNKLNIRVLPCVIGFKDGIVVERVVGFEGLGAGGRDGADSFDIATLEKRLLWKGILTQTKFKNNEDDSDISEGGSGDEGSNRRRPGTGRRTIRSGNGRHHGGDDDDDDDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3B6</accession>
    <name>B0Y3B6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter Mdr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_053630</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0Y3B6"/>
    <dbReference type="TCDB" id="3.A.1.201.10">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053630"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3B6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="821"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="112"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="437"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="780"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1104"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP51357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1349" mass="147724" checksum="B90A86F9D62C4165" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3C6</accession>
    <name>B0Y3C6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_053730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3C6"/>
    <dbReference type="HOGENOM" id="CLU_054969_0_0_1"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3C6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32884" checksum="BF9E7F1D9CBE6711" modified="2008-04-08" version="1">MIGKRKRDTAVVSRSSKTEDEDQTPTVPDTSLAHDLFRKFFEAQFEPLELPGGQISREQESQEDGQGYSDGSEPESEWDGVSEEEGNRVEVVEYQDKITKEKEILDKKARKAFMTAKPPTLSTESTTTKPASKKAKNKKEEDDDDDMDAEHLKNDLALQRLLKESHLLDSASELAPTGKNRLKALDLRMQSLGAKTSLYQQNMPSSLRRGIKAKALMKEEKRRREAKENGIILERPTPKSKVTKGRRERGIAGPGIGKLSGGTLNLSKRDIAVVQSARRSRRGGRGKSKTRGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3K0</accession>
    <name>B0Y3K0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_054470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3K0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054470"/>
    <dbReference type="HOGENOM" id="CLU_599875_0_0_1"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="456" mass="52769" checksum="18F4063AB562EB10" modified="2008-04-08" version="1">MEDEKKPTVAECQVLESSNNHQSALQGISTRLSEGSAKCFIQNEERSTGSQYLFVPSQVLDNRLKCPPGGSMVEEFLTCYSPDFIPPRRYELLRRFLERTGARSFPEAIRSFPADKRILAMIDDRCDPCVSVSLPSGARFLPLRQWESDSYMQRPPEGLHIHVYGADAETLHVNLQKDFHLPYYALRPDQPDLRDSRGLRKHRYFRPPGEEKQDRIYEAQVSLVVFGVDDFFWAAYFCEDTYFSDQDLVATCLQDEVDGPSLGRRMHKFPIWDPRYYFLSILATRTGQITLEWTVLVQSLENVLDRHGEIDQENLNTFLEHDPTLKKTKEYTWILCILRRLRNGLAQAIAALIAFDNNNTVYFDLDADGHLQDKFRECFSHVRQHTAELEALRMILEQRIEIMEKMSGVVSSTSRQFDEQFMTHTHGSWSMPPHSQRVSRPLVKATISDFSRISPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3W9</accession>
    <name>B0Y3W9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_055700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Also interacts with the ATG12-ATG5 conjugate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3W9"/>
    <dbReference type="SMR" id="B0Y3W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055700"/>
    <dbReference type="HOGENOM" id="CLU_027518_2_0_1"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3W9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="353" mass="39769" checksum="FC265B0F402A96E8" modified="2008-04-08" version="1">MNILHSTLSTWRDRLAPVSRTSTFRTTGQITPEEFVLAGDYLVYKFPTWSWADASSPAKRVSYLPPGKQFLVTRGVPCHRRLNENFAGDAGHEDEIVRDMLSGADADDDDGWLRTGGGRDLAEKQAERIKDVRTVDESGNMGEQEDDEEDIPDMEDDDDDEEAIIREPAGKSTTQPTRTYNLYITYSNFYRTPRLYLSGYLSPSEPLPPHLMMEDIVGDYKDKTVTLEDFPWFDGGVKMASVHPCRHASVMKTLLDRADAALKIRRDKLKQAHSADQANRINSERGLEGLVDETRGLSLNEQQGHAAGGDEWEVLQHDEEDQVAIRVDQYLVVFLKFIASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y423</accession>
    <name>B0Y423_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_056250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039278">
        <property type="entry name" value="Red1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563:SF3">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1213"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="169"/>
        </location>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="929"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="840"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
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            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
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            <end position="410"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
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            <end position="510"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="982"/>
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        </location>
    </feature>
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        <location>
            <begin position="1038"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1305" mass="140606" checksum="8D5F61B1752527DC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y458</accession>
    <name>B0Y458_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_056600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y458"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056600"/>
    <dbReference type="HOGENOM" id="CLU_039466_0_0_1"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="PhylomeDB" id="B0Y458"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="260" mass="29445" checksum="A0F43E89B2278424" modified="2008-04-08" version="1">MGNPEVDFSILLNMSSHRADASTLLDNRGYSGPLVRGVNPATLFEKAVRDRITDSYYWKEQCFGLNAATLCDRAVELTSIGGTYGVAEKPTPFLCLAFKLLQLNPEREIILEYLNYTDPGSDEETEATAEEQARNGVLGQRGDFKYLRALAAFYVRLTFDPVDVYKTLEPLLLDYRKLKRRVRDTFVLTYMDQFVDDLLTKDRVCGTSLWKLPARQQLEDLDLLEERISPLADELEEMDRESDQGSDKSGSRSNEAAGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4L7</accession>
    <name>B0Y4L7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_069530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069530"/>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4L7"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000030">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000016">
        <property type="entry name" value="phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="108"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP50616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="572" mass="62145" checksum="8F03FA380089CCC9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Z4</accession>
    <name>B0Y5Z4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_065110</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Z4"/>
    <dbReference type="SMR" id="B0Y5Z4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065110"/>
    <dbReference type="HOGENOM" id="CLU_026444_1_2_1"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Z4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="17">
        <location>
            <begin position="76"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="18">
        <location>
            <begin position="82"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP50179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="453" mass="50169" checksum="235C48971BC1ADF6" modified="2008-04-08" version="1">MVMAPTACVPAEVCMTKHCHDINDYNFNYHSQLSNHGGDDLSQSRLAAKNLVLDVLKKRAAEVDVDRCGPGEEDAFYVADMGEIYRQHLRWKMNLGRVKPFYAVKCNPDPEILRLMAKLGNGFDCASKAEIDLALETGIDPSRIIYAQPCKTKSYLRYAAKVGVKQMTFDNADELYKIKACYPDAELYLRILTDDSTSLCRLSMKFGASLDIARQLLELAHELELKVVGVSFHVGSGAEDPRAFLKAVQDARLVFDQAAEVGHELHTLDVGGGFCQDTFEKFAGILSEALDTYFPPHIRVIAEPGRYYVASAFTLAANVIARRDVRDPKDPANDTYMLYLNDGVYGNFSNIIFDHQHPVAKILTCSGETQPSALNAATSEGIAYSIWGPTCDGIDVITQRIVLPGLLDVGDWLYFEEMGAYTKCSATRFNGFSDNHEVIYISSEAGATALLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y699</accession>
    <name>B0Y699_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_066170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y699"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066170"/>
    <dbReference type="HOGENOM" id="CLU_010289_2_0_1"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="PhylomeDB" id="B0Y699"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000444">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000028">
        <property type="entry name" value="ATP binding L-PSP endoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000004">
        <property type="entry name" value="ATP binding L-PSP endoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="7">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="805" mass="88207" checksum="7D62848D9CD03A1E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6L9</accession>
    <name>B0Y6L9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_067420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067420"/>
    <dbReference type="HOGENOM" id="CLU_099958_1_0_1"/>
    <dbReference type="OrthoDB" id="5274873at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6L9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16303" checksum="D645A220FE333F3E" modified="2008-04-08" version="1">MYYILYLASLCRRRRWPEPQYESYAGTGGYSCIVRVNNREYQTDSVCESETLARENAAMRAYLICRNFSINDGMYPAGHDHGGIVQGIPVAIGTGRKSRYLDDADTSTSGESRSGGSSPDSHEGSRLSLDRQTLDSARTLAFSSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6W3</accession>
    <name>B0Y6W3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_068350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6W3"/>
    <dbReference type="HOGENOM" id="CLU_002370_0_0_1"/>
    <dbReference type="OrthoDB" id="5367052at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6W3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1237" mass="136755" checksum="7E2F42E29192BCD1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7J3</accession>
    <name>B0Y7J3_ASPFC</name>
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        <submittedName>
            <fullName evidence="15">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="15" type="ORF">AFUB_074010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140359">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
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    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC2_TM"/>
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    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
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    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
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        <property type="entry name" value="ABCG_PDR_2"/>
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        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1224"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1289"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1335"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1360"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1393"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1486"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="148"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="883"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="814"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP49374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1526" mass="171811" checksum="6C9EBDD2D9A45F7D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7N4</accession>
    <name>B0Y7N4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 alkane hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_074420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7N4"/>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7N4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="544" mass="61653" checksum="FEB419812D79D0CC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y877</accession>
    <name>B0Y877_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP binding protein (SPG1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_076380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y877"/>
    <dbReference type="HOGENOM" id="CLU_041217_0_0_1"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="PhylomeDB" id="B0Y877"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="388" mass="43664" checksum="988966A6B9A8B380" modified="2008-04-08" version="1">MYRSLCLVSRMSQKPVANRILRSLVPNWRATGESMGPPEFHNGYSSDSRAHYTSHNGGFDSPSTHVSRNQENDQSRVTESPTLTQQPRPPSSSRPGSGLSSGPEQRQGISQTSQDVSQRPPSQPTKNSVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLVGTKYDHFVNFPREDQEEISIQKMTRHVLMISQAKRFAKAMKASLIFSSTSHSINVQKIFKIVLAKAFDLKCTIPEIENIGEPLLLYKNKWYDSLGSIKLALLLLWTPQAPAAKALWGQDPEVGGNTCDSPMGARNQLRWFFDQMQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y899</accession>
    <name>B0Y899_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arrestin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_076600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y899"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076600"/>
    <dbReference type="HOGENOM" id="CLU_057565_0_0_1"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="PhylomeDB" id="B0Y899"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="185"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="401" mass="44363" checksum="A8BF43B4D2803E2E" modified="2008-04-08" version="1">MAAFVRVSGPPNGNFLIGYPGISATMPRIEGKVEIRPSVGITAPVNISLVTVSLHRRETIHPSADSVTKKHLAPPRKELTDIVGKEMLLFRCPAGREYEEVISMDLPFVLFIPFGRGGSDSSRRVPPASLQLPSRTAETYYEIVVTVQQGQSEQRKYAFPVPISRYDTLSTFGMYNRPESAERVTDHLVTLGISLPRWSYGPLDPVSVYVKLSPNPDWMTKARKVTINKITIGIDEEIIYNHEGDEPQRKVKTLVKRTEQIGVKLPPTGFLTNLGLVFPAKDLRDAEGILPRGKAAFPTYAVSGFTTTASLYKIEYYLTVKAHLTSARDITIRQPIVVCPLDHAGCKEEMEAIEQAARDAVHVNPDNPMLPLPSIVRPNDPNALRHLGVAIVGNQKKPLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8C7</accession>
    <name>B0Y8C7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome inhibitor PI31 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_076880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8C7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076880"/>
    <dbReference type="HOGENOM" id="CLU_044125_2_0_1"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8C7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="170"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP49658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="27652" checksum="0C0AAD4A3927AB89" modified="2008-04-08" version="1">MQFLLKIGRLGNNAVVLALALGDDKTSSFDLLVKDYISDSAFPITSADDLARTLRDVFISEARLNDLIGLFKVNVILKLAPGLYKEGYEDTTQALRERQQERPPQHDPLRDDTLPQPARPYPFDDPLAAGPRRPAPPGDFAPPGFEDEYEIYRPPRGYPQGNGGRNPLSIGDRDLYPAGLGPNDPIRGGVGPGLGGGGGGGMHPTFDDPLFGGRRDDGYNPQAPPGSRYDPVGPGGAPSGRGRGPFGGGSGGGFGGFGGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8F7</accession>
    <name>B0Y8F7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_077180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8F7"/>
    <dbReference type="SMR" id="B0Y8F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077180"/>
    <dbReference type="HOGENOM" id="CLU_060552_0_2_1"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8F7"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="91"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP49688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="279" mass="31591" checksum="E69F91B02929A6E5" modified="2008-04-08" version="1">MTSTATVTVPPRITAENVATLFPEVDTSLAREVFPSTVEGSAKDSEELAGYDEEQVRLMDEVCIVLDDDDKPIGSASKKACHLMTNIDRGLLHRAFSVFLFDSNNRLLLQQRASEKITFPDMWTNTCCSHPLGIPGETGAELDAAVLGVKRAAQRKLDQELGIKAEQVPLEKFEFFTRIHYKAPSDGKWGEHETVTDTQILVDYILFIQADVDLNVNPNEVRDTKYVSAQELKQMFTQPGLKFTPWFKLICNSMLFEWWSYLGTADLDKYKGEKEIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8X7</accession>
    <name>B0Y8X7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_078910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8X7"/>
    <dbReference type="HOGENOM" id="CLU_1635007_0_0_1"/>
    <dbReference type="OrthoDB" id="4378821at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="162" mass="19006" checksum="CCD8D5858BD9358B" modified="2008-04-08" version="1">MSPHRHSTSWREKRQVQGRFLDPKKQAKADRERFRRGKWACLKRLNDLYLDGLDVGRERRIYVVVSSKTKSRDGSTHYTTYNTHPDEDWVPPFDEVAEHWPQTDQWKPTDFEKKQGKRQNIRNSQEPTVAQHQLTIPAPPSLQLPLTPILAHFSSQLSVLPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-05-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8Z0</accession>
    <name>HAC6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Subtelomeric hrmA-associated cluster protein AFUB_079040</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AFUB_079040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2019" name="Nat. Microbiol." volume="4" first="2430" last="2441">
            <title>Fungal biofilm morphology impacts hypoxia fitness and disease progression.</title>
            <authorList>
                <person name="Kowalski C.H."/>
                <person name="Kerkaert J.D."/>
                <person name="Liu K.W."/>
                <person name="Bond M.C."/>
                <person name="Hartmann R."/>
                <person name="Nadell C.D."/>
                <person name="Stajich J.E."/>
                <person name="Cramer R.A."/>
            </authorList>
            <dbReference type="PubMed" id="31548684"/>
            <dbReference type="DOI" id="10.1038/s41564-019-0558-7"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the subtelomeric hrmA-associated cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting in a loss of vertically aligned polarized growing filaments (PubMed:31548684). Consequently, this hypoxia-typic morphotype (called H-MORPH) with altered biofilm architecture leads to increased hypoxia fitness, increased host inflammation, rapid disease progression, and mortality in a murine model of invasive aspergillosis (PubMed:31548684).</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is regulated by the hypoxia responsive morphology factor A (hrmA).</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8Z0"/>
    <dbReference type="EnsemblFungi" id="EDP49871">
        <property type="protein sequence ID" value="EDP49871"/>
        <property type="gene ID" value="AFUB_079040"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079040"/>
    <dbReference type="HOGENOM" id="CLU_049464_0_0_1"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8Z0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000460426" description="Subtelomeric hrmA-associated cluster protein AFUB_079040">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="31548684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="31548684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="396" mass="43709" checksum="C7456F87C00D3550" modified="2008-04-08" version="1">MANKKKPSIKKSVNEPNPHLKQSHASGSQQSLGDSLIEYNQPESSIPVCYIQNYPQFSDSYLYEPPFILSKVNEEVGHTVVHFLCTGNYETLRTASEPGASKIGIEFRRSMLVYQAAKEYDLYDLETYAKKYIEVFGESMSIFDIMEAAREIYSKLPKDEIWLTGYIYKQLEIAFSLDRNIFQRVDFYDGVGKDPNFDKDVMRMVVNIYSEVLSRQLDETTPEGSIAEDGAAEDCAAEDGAVEDGVVEEGAVEEGAVEEGAVEDGAVKDGAVEDGAVENGVAEECGAAEDVADDGALKEAVNLGIPSQPSGTALSFEWDHWTSGSKMGASFSGNSQWKYEKDTNSLYPENKAEESGGFNAAYEGIKSKKKKDKKKKKSNKDKKVEELAEPVPECGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9F3</accession>
    <name>B0Y9F3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9F3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080830"/>
    <dbReference type="HOGENOM" id="CLU_020416_0_0_1"/>
    <dbReference type="OrthoDB" id="3437405at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="519" mass="58929" checksum="8B2D1E52E98FB97B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9K0</accession>
    <name>B0Y9K0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_081310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9K0"/>
    <dbReference type="HOGENOM" id="CLU_015161_1_1_1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9K0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="93"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="471" mass="53955" checksum="983EFAA4F0AF50A7" modified="2008-04-08" version="1">MYAFPHLASTNCSRGCRPTRGRESVLEDAKDLAETRFTQGSQPRDRRDSSYSDPSPPNLAFDDASPQPSSLAVARAVDSYMKYCHRQPVWCFNFEEHGDLESIPEELLCSIIALTARFSHEGEHGQHHADTAKSLIMLRIANGTVELSTIEALCLLAYSSFIDGDMHLGRFHLGLAFQLCRSALLDTESAYTPGDPNTERKKRLFWSLQLLEQSYGRQTGLLSIPLETWRPADYFSGNSKEPQRDAEKPPPLPRDTIGCAAPDDTGIWSMTVHFGWVWSKVRTYVSDCANNRLREPWRHESMYSMVLSDLTEIENQTPLCHRYDHVRFYDRQPDELIVNRAYWIPWLKLQFMYHAILIVLNHPFLYIMASRHNPNLAIPNSFWRRSSELVLLHATWIVRMIDMLSDKDVRLTDPFFAHVAAIAATVQLYYCCAGDPRLKYKSRADLARCRVFLRSFVPFSRACASLPAPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9K6</accession>
    <name>B0Y9K6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_081370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081370"/>
    <dbReference type="HOGENOM" id="CLU_044876_3_3_1"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9K6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="301" mass="33095" checksum="DB1BB97394C06F66" modified="2008-04-08" version="1">MSSSIKKVIVAGAGGHLGPHIVSAFDSDPNFEISILSRRSSKSTFPPHIPVHRVSDDYDETELVEVFTGQDAVICTIAMQAIHQQKAMINAAVKAGVKHFVPSEFGHDTRNDQAAAMLPQFYAAKRQIVEYLKSKEGDGLRWTAFVTGPFFELAVGNFLGFDMERRHATMLDHGTNRWSATTRSTVGLAAKNAMLGPESVSNQYLFIESFNVSQRDVLAALEDVTGTRWDVTYHDAEEEKRLALEKLAKGNYSGIPALMRYITCAKGYGGNYMDSEESANKLLSLPAESLHAVLAGLTRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA09</accession>
    <name>B0YA09_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_082950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082950"/>
    <dbReference type="HOGENOM" id="CLU_010170_0_1_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="B0YA09"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="875" mass="97473" checksum="192C35EB2B8ED391" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA40</accession>
    <name>B0YA40_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_083320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083320"/>
    <dbReference type="HOGENOM" id="CLU_052832_0_0_1"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="340" mass="38322" checksum="C2B089CF6991CD7D" modified="2008-04-08" version="1">MSFENLHCHSNMASHLSDRFLWLCLGVSLFFAIRGIAADLRRVSDLTEIKHVEKEDKIISEGTEDALKLDTLLKLSDSTSYDLRAAALRIIAERSTKGPTRDLLLKDLASKNKERRGRALTALYFLLSNRALSRTSVCSRLKDLSTYNALVDCLCNFLEEHVEETSTTDSPILPKTRPLGEKKALNILNLILRENIPAALEAGVISRWLSKYPFPCALTEPSRRQDVVILMKTWWSDDTIMSEIFSTLSSHPDGTKQLRKYGLMGSMMEENDHDDDDEDSDVWMIDGEDTAGSSHLSGRRLRGGTAAEQAVRRRRREAMVLSDGVHPLNNDDIFQIPITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAE8</accession>
    <name>B0YAE8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_084420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084420"/>
    <dbReference type="HOGENOM" id="CLU_129944_0_0_1"/>
    <dbReference type="OrthoDB" id="4502040at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="177" mass="19181" checksum="018BFF8383453468" modified="2008-04-08" version="1">MSFIPTTLYYASAAIHAVSIPGHVLFGIREVDPAIATIPPSEKHALGKATATTAWDMVNALLAASALLNIQWSRVGVRTLEEKAIIWTTVLAGTFTGWRYFKVRSYAGLGCLWVAPWLTAGAMVYEKLGSAPLSRGHSGHLPIGSVVFHRFRAPSAICVLRWKSKYHTGFASEISGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAV6</accession>
    <name>B0YAV6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ham1 family pyrophosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_085979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085979"/>
    <dbReference type="HOGENOM" id="CLU_1721919_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0YAV6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="152" mass="16885" checksum="C0D6B65C74734B5A" modified="2008-04-08" version="1">MPLTYKNTIPCAMIKAEQMKGPVLTEDSALEFLAINGLPGPYVYVTETLGLYAVQEFYSALEITDCVSFWLCAFSSRPGVEPVLFQGRVDSQTVTPRGSNGFAFDPIFEVQGRIRRDAQTKACQARGKNKVIYRWTTRISCQNCSARAQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB12</accession>
    <name>B0YB12_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_091190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091190"/>
    <dbReference type="HOGENOM" id="CLU_031875_1_1_1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="PhylomeDB" id="B0YB12"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="68"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="470" mass="55087" checksum="8A44F6CD05CA4497" modified="2008-04-08" version="1">MAVGILKVKGNKVVDNDGNEVLLRGAAIGGWMNMENFITGYPGHESQHRAAMRRVLGPEKYEFFFDRWLEYFFTEADAKFFAGLGLNCIRIPFNYRHFEDDMNPRVLKESGFKHLDRVIELCAKEKIYTILDMHTAPGGQNGDWHSDNPTSYAAFWDFKDHQDRTVWLWEQIAARYKDNPWVAGYNPLNEPCDPEHVRLPAFYERVEKAIRAIDPDHILWLDGNTFAMEWKGFDKVLPNCVYAMHDYSSMGFPTGERYKGTPEQKEHLERQYLRKAEFMNKNGTVIWNGEFGPVYANPRTEAEAETINQERYSLLGEQLRIYDKYKIHWSIWLYKDIGLQGMIHTSPDSKWNRTIQPLLEKKKKFWLDAWGREPFAEPEAALKPLVDWIDKVSPTAKETYPTPWNTERHLLRNVFQTFLAASFVNEFAELFRGMDEKELDELAHSFHFDECEQRGGLNEILREHARATKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB28</accession>
    <name>B0YB28_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HbrB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_091350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091350"/>
    <dbReference type="HOGENOM" id="CLU_005193_1_0_1"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="PhylomeDB" id="B0YB28"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="826" mass="88645" checksum="CA0D101211F128D1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB57</accession>
    <name>B0YB57_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_091640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091640"/>
    <dbReference type="HOGENOM" id="CLU_1777019_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="146" mass="16568" checksum="22EA91BA1B7BB2FE" modified="2008-04-08" version="1">MARSKPQDIALSNFYINESYSRRMADDKSGAPSSSSTLARNDMPQASQRSQPTASVRPDTRPPPLLCNRDRYWEDDGRCRWVVNRDFLVPPGMVGIDISDFARGLLISGTARTWRQHSNQESFMETSAVYKKTFLKFSLSAWLATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBF4</accession>
    <name>B0YBF4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_092620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092620"/>
    <dbReference type="HOGENOM" id="CLU_888631_0_0_1"/>
    <dbReference type="OrthoDB" id="4504449at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="40767" checksum="754ABECF44C2C2F7" modified="2008-04-08" version="1">MFQAQCRQVFEFTEIDEIYPALLNLRRPTLPFNAKVTHDHLRPLQKLAQDLKAGAQALENAYKLGTGYDDLAVVLLEPSDKADTHCFDDMLNASMALKAVDSSIRHAFNGHRSIQNTIILDIRAFRSDSIRRTQGASDKLEADELAYTAFEQILCNLKPDVILVCQCQTNTNEVGSRFARQACSSIDEATDITVLRLPRTQHESVMVKSFHPMYLEYMREAPNDSATKAVLREYLFDAGFIIASNALAGRSITGFGLHNLKACARDGPAFIATPQGVRISYLWTSGSDIASTELVEALKTLGISSKDENTARLDRIFSGLRIRSDRGSGFGNDNAVEREAFRKDDILERIGPIPKLPQGIIPLCGALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBH0</accession>
    <name>B0YBH0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_092780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBH0"/>
    <dbReference type="HOGENOM" id="CLU_1102559_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="PhylomeDB" id="B0YBH0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="252" mass="26618" checksum="7B12D189BB508E8B" modified="2008-04-08" version="1">MDNGTYCLPEPCDVAKIWVDGGIWGTELIKPDGPYSNISYIQFMRWNAAALHEPVFPGDTICIGPPGGAYAPPAAPIPVSPNATFTTTAVPAMGTPPGTVSNCGLYYDTVTGDDCNMIAMKYSITFSQLRLMNPQINADCTNLWANTSYCVALVSGTTVTTTASSSATPTRSSSSGSTSPSPTSSTVAPPAPTQPGATSSCYEWYVAVPGDDCSKIDTQYGITFAQLRAWNPYLDSTCSNLWSDYAYCVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBL2</accession>
    <name>B0YBL2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_087020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087020"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_2_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="PhylomeDB" id="B0YBL2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="515" mass="56223" checksum="10E185B085415F62" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBW3</accession>
    <name>B0YBW3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein, Mpv17/PMP22 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_088040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBW3"/>
    <dbReference type="HOGENOM" id="CLU_049109_8_1_1"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="PhylomeDB" id="B0YBW3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="178" mass="19753" checksum="E514EB93FC4A6107" modified="2008-04-08" version="1">MLRWYISSRYQTKLAKQPILTASVTSAVLFGCGDILAQQAVDRKGFDKHDLARTGRMALYGGAIFGPAATTWFAFLQRNVVLKSHKATIIARVVADQGLFTPTHLTCFLTSMAIMEGTDPIEKWRTSFLPSYKANLTIWPLVQGVNFSIVPLEYRVLVVNVVSLGWNCILSLINSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCD2</accession>
    <name>B0YCD2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_089770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089770"/>
    <dbReference type="HOGENOM" id="CLU_062461_0_0_1"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="PhylomeDB" id="B0YCD2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760840" description="Protein BIG1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="12">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP48263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="290" mass="31674" checksum="22376F2CDCCC57B5" modified="2008-04-08" version="1">MRLGRLSLLALGAASANAFRDTSPFFLASTSDILATSSNIKAATSVLEDLSSQLSTCPSDYYVIASQPGVHSSDFATRKSAPRLGAKLTGNDKAIRSSMIVKEVAGVLEAKQIQSIIEKECGARSTLIDASASSYPSEFGAEPRIIYVDFPMLSLGADRAQQLSDNDGLLANIIDRIPSSKKYTLLYVTSPREFEGSEGVVYKAEDSYQDPLRMELKRDYSAHESQSTPASNKSLFREYQYLTPGLFMGFLAAFFFLMILYVGIRALTSLEVPYAAFEKDTSASVQKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCF7</accession>
    <name>B0YCF7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_090030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090030"/>
    <dbReference type="HOGENOM" id="CLU_178987_1_1_1"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="PhylomeDB" id="B0YCF7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="56" mass="6191" checksum="66FCCB8A85E3C4F0" modified="2008-04-08" version="1">MDSAKQPVKLVKVTRVLGRTGSRGGVTQVRVEFMDDTSRSIIRNVKGPGMRFPLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCJ4</accession>
    <name>B0YCJ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo-keto reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_090400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090400"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B0YCJ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="355" mass="40248" checksum="34EEAE06CF563722" modified="2008-04-08" version="1">MAAELPPLLKASLEQTKVSYRQLGKSGLRVSVPILGGMSIGSPEWGSWILDEEKALPLLKAAYDRGLTTWDTANNYSNGKSEEIIGKAIKHYNLPRHKILILTKCWSPVSEHDNHYVVPFADNMRQDKEYVNQFGLSRQAIFNAVNASLKRLGTDYIDLLQIHRFDPLTPIEETMEVLNDLVRSGKVRYIGASSMRTYQFIMMQHCAEKHGWTKFVSMQNQYSLLYREEEREMNRFCNETGVGLIPWGPLDGGKLARPLSQVRGTTRSENTDPNAVTKADEMTISRVEELAKNKGWTMGQVALAWVKKRVASPIVGFSSVERMDEMIQVADRILTTDEERFLEEPYVPKPIGGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCT3</accession>
    <name>B0YCT3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial folate carrier protein Flx1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_093110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093110"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="PhylomeDB" id="B0YCT3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000102">
        <property type="entry name" value="Folate carrier protein Flx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="224"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP47467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="308" mass="33716" checksum="51B95AF64A85F2BC" modified="2008-04-08" version="1">MTIKDGLSSSFVETIAGFTAGIVSTLCLHPLDLLKTRLQVDRSSPSQLGGSLRVIREISRREGGITAFYRGLTPNIIGNSTSWALYFLCYGKTKDLMRRLRGSRVLELTSADYFVASGLAGLATSFLTNPIWVIKTRMLSTGSNAPGAYASFTTGVTQIYRSEGISGFYRGLLPALFGVSHGALQFMAYEKLKAYRTRMSSASRTSGDSIGLGATPARQLGNIDFFLTSSLSKIFAGCVTYPYQVLRSRLQTYDAHLVYRGVRDAMAQIWAQEGFGGFYKGLGPNLLRVLPSTWVTFLVYENTKSCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD78</accession>
    <name>B0YD78_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS allantoate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_094580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094580"/>
    <dbReference type="HOGENOM" id="CLU_655483_0_0_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B0YD78"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001164">
        <property type="entry name" value="MFS allantoate transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="419" mass="47965" checksum="0225EFD800E88F96" modified="2008-04-08" version="1">MGNMSSEKTLQNNKHADDLGEGAMQQIQECSAFSSTAEKRLVRKIDIMILPIMTFAYMMAFLDKQALSYTAIMGLRTDLNLKGSEYSWSGSIFYFGYLFFSYPASILMVKFPLGKYLACNLFVILPKRLGLILTMNSMLWAIVLACHAATTNFAGLMVARFFLGCTEASVSSGFSLITSLWYRTSEQPLRHGIWFCGNSISMIIGNLVAMGIWQIKTGLQPWKWLFIIFGIVTFLWGILMFFRLPDTPNTASFLTEAEKLLATERLKANKAGYKRNKIDTSQIIEAFIDPKTWLLAPHSLRLRLLNLQDLAAGYARWRCNPRLRLTLLHHILQNPQLPLHRHRRSRLYQHPRQRPCLRHRVHRRAVRRPPSHGGVLGQHAPEPGNGCFEYRRVQQAGDCQRDLFRHVLHGEYCWAAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDN4</accession>
    <name>B0YDN4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_096200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDN4"/>
    <dbReference type="SMR" id="B0YDN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096200"/>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="PhylomeDB" id="B0YDN4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="161" mass="17724" checksum="6207441CA6BED8CB" modified="2008-04-08" version="1">MATDVVFDTSMGSFTVELYNEHAPKTCRNFATLAQRGYYNNVIFHRIIPNFMVQTGDPTGTGRGGSSIYGEKFEDEIHPGLKHTGAGVLSMANSGPNTNGSQFFITLAPTPWLDGKHTIFGRVKSGMRVIQRMGLVKTNSEDRPVDEVKIIRAKVVEEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEI1</accession>
    <name>B0YEI1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_099260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099260"/>
    <dbReference type="HOGENOM" id="CLU_785196_0_0_1"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="PhylomeDB" id="B0YEI1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000199">
        <property type="entry name" value="Glycine dehydrogenase [decarboxylating], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="4">
        <location>
            <begin position="83"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP47325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="353" mass="39110" checksum="33086B67262F7A80" modified="2008-04-08" version="1">MAASLCALRGTRQLVIRTRLRASPASISLRKAAPSPVLATRRYLNTATQAPPASRRAVYTSSVADHGDPHPRDLFQPLDTFPRRHIGPSPEAAQEMLAALDPPVATLDEFVKQVLPADILSKKDLTVTPPSADINLPRSSVHGGLGETDMLKLLETYRKQIDISGKSYLGTGYYPTIVPPVILRNILENPAWYTSYTPYQPEISQGRLESLLNFQTLTADLTGLPFANASVLDEATAAAEAMTMSLATLPMAKQKKPGKAYVVSHLCHPQTIAVMQSRAEGFGINLVVGDIMANDFELVKKQGDNLHWCSRAIPRYRGWCVRFPGSERQHPRRWWHLQRCYRSPRIDPPQGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEX4</accession>
    <name>B0YEX4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Succinyl-CoA synthetase beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_100820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100820"/>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_1"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="PhylomeDB" id="B0YEX4"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="10">
        <location>
            <begin position="45"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="9">
        <location>
            <begin position="268"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP47087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="394" mass="43309" checksum="7294F6884996B77F" modified="2008-04-08" version="1">MNASLTVTSEPPRASFPQTSRAVFNPSTTRLCGHKSGGCGGGRAPSVLKSQILAGGRGKGKMSSDGKGGIRIVATPEQAFQNASRMLGHYLATQQTPPHGLLVKKLYIYKAVDVEQEFYLALTFDRERYSPVILISDQGGVNIESNQDKLHRFWFNLSRGITGETMAGIQKQSCFTDKEMPTIESIIRQMIKLFEERDAILLELNPLVRTPEGSFVCLDAKFEFDNAAQFRQPEVFSKEERMPGFEDEYEAQMHGLVYIRLNGHIGNIVNGAGLAMATNDLINLHGGKCANFLDIGGKATTETLLKAFEILSRDQQVRGIFVNIFGGIVRCDMIAESIIQAAHTLGGFRVPVVVRLQGTNCDAAMKRLSTSELDISTETDLEKAAKRIIGLTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF26</accession>
    <name>B0YF26_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_101340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF26"/>
    <dbReference type="SMR" id="B0YF26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101340"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="PhylomeDB" id="B0YF26"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP47139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="486" mass="53280" checksum="E6807313929BDA0A" modified="2008-04-08" version="1">MPYWQELFSTGYRDPTGHPNITSSQSAAIVSILSAGTFFGALGAAPMGDRIGRRWGLIASAQVFNLGVILQTAATGIPLFLAGRFFAGLGVGLISALIPLYQSETAPKWIRGTIVGAYQLSITIGLLLASIVNNSTQNRMDTGCYRIPIAVQFAWSIILVGGMLILPDTPRYLIKRGNIDGAARALGRLRRLPADDPAVREELAEIQANHEYELSLGKSTYLDCFKGNLLKRLLTGCGLQALQQLTGINFIFYYGTQFFKNSGFKNSFTISLITNCVNVGSTLPGLYAIEKWGRRPVLFWGAVGMCVSQFVVAIIGTTTTGQDAHGVIIVHNEPAQKAAIAFICFYIFFFASTWGPSAWVVTGEIFPLKIRAKSLSMTTATNWLLNWAIAYSTPYLVDYGPGNANLQSKIFFVWGGCCFLCISFVYFLIYETKGLTLEQVDELYGEVSSARLSKHWTPTITFREMQQEKARDVHLETAEAAVPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF43</accession>
    <name>B0YF43_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_101510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101510"/>
    <dbReference type="HOGENOM" id="CLU_010839_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="658" mass="73534" checksum="A7780AA8585F28A0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YFA3</accession>
    <name>B0YFA3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_102100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YFA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_102100"/>
    <dbReference type="HOGENOM" id="CLU_703946_0_0_1"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="PhylomeDB" id="B0YFA3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="120"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="392" mass="45339" checksum="369C24D53E4F43DA" modified="2008-04-08" version="1">MRADENAERCEDYLRDLLMWRETKTRSYLLQIPTSGNARKNIFSSQKMDRPPLFQSQTTGSNLPGSISKTSCGDYCTSAIRNQGPRFPTINGRRAVIMTRPWSIWSASGKIGIRSRPPRITPPPHKYYTIQLQDKFREHGLQIIVKMENIELTPDSGSYKGTDWRMEGQLNEHLVAAAVFAYDVANITEPRIAFRQNTKLDERFYRCSEDREQRRKVHPRHDVPAQQCGKYGSTEFAAVAEILGFSTADLDPCCNHAVKTWQDKGTVRVLQGRLVTFPNLLEHRYEPFALADPSRPGCFRFIVLYLVDPHYRVCSTRNVPPQQHHWWAESVSHNLAAAGLPQEIVDEIMQGTGSWPMGLPEARRHRREFLKEHRWNNLVRIYCMRRPSFDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM53</accession>
    <name>B0XM53_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_000960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000960"/>
    <dbReference type="HOGENOM" id="CLU_013869_2_0_1"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="PhylomeDB" id="B0XM53"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="712" mass="78357" checksum="A0A7CF7CCA0596F0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM61</accession>
    <name>B0XM61_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_001010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001010"/>
    <dbReference type="HOGENOM" id="CLU_3031934_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="55" mass="5972" checksum="2A41A4E65B05072E" modified="2008-04-08" version="1">MHRRQGHASLNLESCLRGRGGYSIWLSVISFRGGNPDQLCRLAGGCQAVQEGQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMJ9</accession>
    <name>B0XMJ9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_002990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002990"/>
    <dbReference type="HOGENOM" id="CLU_053567_1_0_1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="PhylomeDB" id="B0XMJ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000062">
        <property type="entry name" value="rRNA processing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="3">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="325" mass="36297" checksum="9E6C60C7AFA2928F" modified="2008-04-08" version="1">MRAKRSKKYRKLMHQYEMAFGFREPYQVLVDSNFLRAVHTFKMELIPALERTLQGKVKPLLTKCSLAAIMASQPINPKTNNPYRPTHLPPPTILPLRHCSHNEDSTPIDEVECLLSLLSPSKEVKRNKEHYTLATADPPAPAKADSGDGKKRKRGADEGRDALRRAQKLRIGARSIPGVPIVYVKRSVMILEPMSTPSEEVRDGVENRKFRVGLNDEAVLGKRKRTEDGEEKKKKRGPKKPKGPNPLSVKKPKKKPAETASGPKQEKRKEQKLDEAPDRTNDDGESGAPKPKRRRRHHKSSKGDGNDDHAGEPSNGADAATASNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMK2</accession>
    <name>B0XMK2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_003040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003040"/>
    <dbReference type="HOGENOM" id="CLU_029404_1_0_1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="PhylomeDB" id="B0XMK2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="376" mass="42131" checksum="6C5FEE47251CB8CF" modified="2008-04-08" version="1">MVTQDTVTTILLMIRSPQWTAARTTSSRRLIRPRTPVRQYRAAVLPSYGITTPVPDRHPHSKSPFCFQTGYALCAKRPSRPFPPPFLSPPSSSFSDPLTTHYQSQDKRLSVGGELVRGLNNGDDAVLVADNFIGVNDGVGAWATKERGHAALWSRLLLHFWALEAEREVDRTSKLDPIEYLQRAYEETIRATTSPNEWLGTTTTVTALLHFTGDNAENAKPLLYVTNLGDCKVLVIRPSEEKVLFRTTEQWHWFDCPMQLGTNSVDTPRKDAVLSEVQLEVDDLVLAVSDGVLDNLWEHEVVTITLDSLKKWDGGHLEEKDIDWATPAHLADRRMVFVARELLKAALAIAQDPFAESPYMEKAIEEGLAIEGGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMU1</accession>
    <name>B0XMU1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_014160</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMU1"/>
    <dbReference type="HOGENOM" id="CLU_044271_1_0_1"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="PhylomeDB" id="B0XMU1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757684" description="tRNA(His) guanylyltransferase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="15">
        <location>
            <begin position="72"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="16">
        <location>
            <begin position="207"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP56698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="374" mass="43899" checksum="CFCFB6BB75EE5BE8" modified="2008-04-08" version="1">MLRMFSVIVVWVFKCLGLIWQQSWLNSCSPHSFPHSREISFDQPAKTERDSLRHPRNEGYTRHFAEMANSKYEYVKSFEQPDVLLPNTWIVVRIDGRGFHKLSDRYGFIKPNDRRALDLMNAAAVEVMKELPDLCIAYGVSDEYSFVFHPSCQLFERRSAKLVTTIVSTFTAHYIYHWGTYFPSTPLHPPYLPSFDGRAVLYPTTRILRDYMSWRQVDCHINNLYNTTFWTMVQKGGMSNTDAERELQGTVSSDKNEILFKRFGINYNNEDEMFKKGSVVYRQVGQQGCLYDRRLTWILQYQLEDPKPESKSRHGDDDEAPMDESKISRAQQDKLRKLRRKAQVVVDHVDIIKDEFWERRPWILSGKPGKLPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN46</accession>
    <name>B0XN46_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_014550</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="341"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="542"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="295"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="757"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="691"/>
            <end position="731"/>
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    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="310"/>
            <end position="338"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="74"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="87"/>
            <end position="112"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="168"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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            <begin position="180"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP56736.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="830" mass="91618" checksum="30CC22B70EDF7FCC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN47</accession>
    <name>B0XN47_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_014560</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
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        <property type="protein sequence ID" value="EDP56737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PHI-base" id="PHI:9565"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:2-isopropylmalate synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
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    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="IPM_Synthase"/>
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        <property type="entry name" value="LeuA-like_post-cat"/>
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        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
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        <property type="entry name" value="LeuA_N_DRE-TIM"/>
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        <property type="entry name" value="PYR_CT"/>
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        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
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    </dbReference>
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        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
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        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
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    </dbReference>
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        <property type="entry name" value="PYR_CT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP56737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="643" mass="71195" checksum="9E11B2CBAA8220D6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNR5</accession>
    <name>B0XNR5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Urea transporter (Dur3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_005210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005210"/>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="PhylomeDB" id="B0XNR5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="677" mass="73124" checksum="B24D9FED05593A7C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNU9</accession>
    <name>B0XNU9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_015740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015740"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="B0XNU9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="497" mass="56787" checksum="7F7DD3DD0ADED692" modified="2008-04-08" version="1">MPSPAPLPPHFTWGFATAAYQIEGAVDEDGRGKSIWDTFCHLEPSRTKGANGDVACDHYHRYEEDFDLLARYGAKEYRFSISWSRIIPLGGREDPVNEAGVAFYNKLIDSLLARGITPWVTLYHWDLPQTLHDRYGGWLNVEESQRDFERYARVCYERFGDRVKNWITLNEPWIVSIFGYATGGNAPGRSSINPQATEGDTATEPWIVGKALIMSHARAAALYNREFRSVQQGKIGISLNGDYYEPWNAEDERDHAAAERRMEFHIGWFANPVFLARDYPACMREQLGARLPKFSPSDFALLREAESDFYGMNYYTSQFARHRDQPASETDYIGNVDELQENSKGTSVGEPSGIHWLRSCPDKFRKHLTRVYRLYGKPIFITENGCPCPGEDRMTCEESVNDMYRIRYFEDHLEAVGLSVNQDGADIRGYFAWSLLDNLEWSDGYGPRFGVTFTDYQTLKRTPKKSALLLRRIFEERIGISTKGQAPSAPGVFRAEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPE4</accession>
    <name>MKK2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitogen-activated protein kinase kinae mkk2</fullName>
            <shortName evidence="5">MAPKK mkk2</shortName>
            <ecNumber evidence="7">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mkk2</name>
        <name type="ORF">AFUB_006190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="909" last="918">
            <title>The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Valiante V."/>
                <person name="Jain R."/>
                <person name="Heinekamp T."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="19715768"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2009.08.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Mitogen-activated kinase kinase (MAPKK), part of the cell wall integrity (CWI) signaling pathway composed by three protein kinases bck1, mkk2 and mpkA and responsible for the maintaining of cell-wall integrity balance (PubMed:19715768). The CWI pathway also regulates the oxidative stress response, as well as the production of some secondary metabolites including pyomelanin (PubMed:19715768).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to the formation of thicker hyphae, which appear less elongated and form more branched hyphae (PubMed:19715768). Results in increased sensitivity to cell wall integrity inhibitors such as glucanex, SDS, congo red and calcofluor white (PubMed:19715768). Impairs phosphorylation of the MAPK mpkA (PubMed:19715768).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="7"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPE4"/>
    <dbReference type="SMR" id="B0XPE4"/>
    <dbReference type="EnsemblFungi" id="EDP55917">
        <property type="protein sequence ID" value="EDP55917"/>
        <property type="gene ID" value="AFUB_006190"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006190"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="PhylomeDB" id="B0XPE4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06621">
        <property type="entry name" value="PKc_Pek1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000454885" description="Mitogen-activated protein kinase kinae mkk2">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="211"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="217"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="19715768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="19715768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="19715768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="503" mass="54781" checksum="A763A873AA99F4BA" modified="2008-04-08" version="1">MSSSPVPLLRPPVPGNRGNGPRPPKLTLGIPPSPNSRPVDGNGVGPAAAAPEAPQPQRPSTRPAPPQLRLATPMGSSSDVPQEVPRLANGRPAPPPLATTGLNESTGHSRSSSFTYLDGKASGPASASSSNYSALSFAMGLRQPHGSTPDPSSAISSVYSDREGGVQMERDNSVNGLLPDLDKLSLEKGRPLDVDDLDDEGWLAASEQKKIIELGSLGEGAGGAVTRCKLKDGKTVFALKIITTDPNPDVKKQIVRELNFNKDCASEHICRYYGAFMDKSTGTISIAMEFCEGGSLDSIYKEVKKLGGRTGEKVLGKIAEGVLNGLTYLHSRKIIHRDIKPSNILLCRNGQVKLCDFGVSGEFGTKGDANTFIGTSYYMAPERITGQSYTITSDVWSLGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVRQPIPKLKDEPENRIRWSDNFKYFIECCLEKEPPRRATPWRMLEHPWMLDMKNKKVNMANFVRQVWGWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPE8</accession>
    <name>B0XPE8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_006230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006230"/>
    <dbReference type="HOGENOM" id="CLU_015328_0_0_1"/>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="PhylomeDB" id="B0XPE8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="73198" checksum="859390EAB688967C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPF5</accession>
    <name>B0XPF5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_006300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006300"/>
    <dbReference type="HOGENOM" id="CLU_582628_0_0_1"/>
    <dbReference type="OrthoDB" id="3539644at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="469" mass="50739" checksum="FD1732BB05987D1B" modified="2008-04-08" version="1">MMSEIGLSDNHHDSASTCQLSMPDEDQSHSAAPLLPKPEDYETAPADGMKELEMGDIKNPSLSPSPRPGSIFTVDDDEWTPRFKRSHTRARRARRACLLFLLKAVLAVWFSAVLYNVIRYCAKQSPKTGDLPDTSTNTSDGGSPASTPTSNDRRMKIDSNAGNIHGVYPLYDSLTLTTTTGNITVAIAPQPAHPDHPFEPARLHIRSLSGTVTISFTAPEAAVLPDLELAMELELELHQDGNDSLPHDEIMKTCDLPARPYELDIQTDSGPIAGRMVFSRSARLVSGSGDITAMLIPVIGGVGEDCSREMWRNVSIVTGTGTGAQRVHVTEPYILRSKAGLRSKAGDDAVANYFVAGCHVGGDGSMEVAYPAAWAGNVHVRTEGGSVRLGGEGVEVVESGEGMVDATVGTRRINGDEEDDDDDDDEESDDDEDEDDDDIEEDDNDKRRLGGWMDVSFRSKEGSILFYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPH2</accession>
    <name>B0XPH2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_006470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPH2"/>
    <dbReference type="HOGENOM" id="CLU_023414_1_1_1"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="PhylomeDB" id="B0XPH2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="60977" checksum="ED0C71C67FB9909D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPT5</accession>
    <name>B0XPT5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_007510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007510"/>
    <dbReference type="HOGENOM" id="CLU_008279_3_0_1"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="PhylomeDB" id="B0XPT5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="406"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="789"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="818"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="872" mass="95465" checksum="4AC3A1D0E4764588" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPU4</accession>
    <name>B0XPU4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_007600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPU4"/>
    <dbReference type="HOGENOM" id="CLU_018876_0_0_1"/>
    <dbReference type="OrthoDB" id="2364732at2759"/>
    <dbReference type="PhylomeDB" id="B0XPU4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="536" mass="61775" checksum="7CDFDABD54C018B6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPU7</accession>
    <name>B0XPU7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_007630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007630"/>
    <dbReference type="HOGENOM" id="CLU_159428_1_1_1"/>
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    <dbReference type="PhylomeDB" id="B0XPU7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000075">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8921" checksum="62FA8EE88623CD97" modified="2008-04-08" version="1">MAGTQKLYPRGTVKGIVKAHSNRSLSKNADILIFLDYMLFMQELMREASIRSRKAGEKYVSPNSVRKVTEKTLRKFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQD5</accession>
    <name>B0XQD5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Digeranylgeranylglyceryl phosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_009570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009570"/>
    <dbReference type="HOGENOM" id="CLU_063928_0_0_1"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="PhylomeDB" id="B0XQD5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35291" checksum="A6CD48A72B5B2336" modified="2008-04-08" version="1">MSIGGPSFHVCRFPSAVASGGYTIWLFIASDIQTILLPSTIFGITNALATRDFRDVQSQFSAYLNTVYRIPLVIGWVGINLLPLTMNNQRSPSSIAEDSLNKPWRPLPSKRLSGPQAKRLMFGFYALAVVYSCFYSGGLRQCLGLIILGTCYNSFGAGDHNPVIRNIINALGYFCFNSGAVEVALGSGSAVFTERPEARQYSLRLWIMVITAIILTTMHVQDMCDQEGDAKRGRRTLPLVIGDAAARWSIALPMPVWGVICPLLADSGPLATGLSFMLAFAVAIRMLMWRDTASDRMTFRVWNLWISVVYMLPLLGSVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQQ3</accession>
    <name>B0XQQ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 88, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_010770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010770"/>
    <dbReference type="HOGENOM" id="CLU_038720_0_0_1"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="PhylomeDB" id="B0XQQ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF11">
        <property type="entry name" value="WALL GLYCOSYL HYDROLASE YTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="516" mass="56732" checksum="EA0E3A556C4D97C1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQS0</accession>
    <name>B0XQS0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_010940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010940"/>
    <dbReference type="HOGENOM" id="CLU_871464_0_0_1"/>
    <dbReference type="OrthoDB" id="4344543at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760081" evidence="2">
        <location>
            <begin position="30"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="319" mass="34289" checksum="12E493B4130051A8" modified="2008-04-08" version="1">MRSGIQKPGAIPFFALILFSILSLVPSLAKEWGFYNLQIGYRAYSRSEDWHLPRVKDGAIEVRPRTSSAGTLCKSWLAGGSFQSCPNRKGRPRRGALDAPSLSAFEAASVFDSEPLTQTATRSSSLTRGVHAFKAFFIKQLDDCQILQPFLPGSAPSVPKSTSRPVPPSVNSSVAPVPLLSEEPQRWSRITNQTTSATKHILESSRIRFLSGCHDAWQQACLVAMDFLKSFPSALGTQPFPSNSTESGFPLQLPGQEPGRKSAPQPLPADALAAPTKPITQAAPAAGQSEVAAVDDSPKKMRGSCMAIVIGLVVGVIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRA7</accession>
    <name>B0XRA7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_012690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012690"/>
    <dbReference type="HOGENOM" id="CLU_005258_0_0_1"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="PhylomeDB" id="B0XRA7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1492" mass="166790" checksum="BC13B7BD782FE092" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRF3</accession>
    <name>B0XRF3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002270"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="PhylomeDB" id="B0XRF3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="315" mass="34303" checksum="5BF39919809BE229" modified="2008-04-08" version="1">MYPNPPPVAIPTSYESLQTTHIKVSHHPAGSPTVTPVVIVTLNRPDKHNAFTLAMAEDLERVFGMFDLDERVKVVVLTGAGKTFCAGADLEIGFGGGRERERTADHRDSGGRVALAIHRCRKPTIAAVQGSAVGVGMTMILPAAIRIAHESSKYGFVFARRGITMESCSSYFLPRLIGYSRAMFLVSTGGVYPPNSKHFDGLFAETLPEGTQVLPRALELAAEIAENVSPMASALNRALMWRGPESPEEAHLLESGILYHMFGARDQREGVSAFFEKRKPNFKATLEHDGPANYPWWSEASIDPPAKAAKESSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRV4</accession>
    <name>B0XRV4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_024960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024960"/>
    <dbReference type="HOGENOM" id="CLU_033831_0_0_1"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="PhylomeDB" id="B0XRV4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000394">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000135">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="10">
        <location>
            <begin position="205"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="424" mass="46984" checksum="7EB932C49AEFC067" modified="2008-04-08" version="1">MADPLADFGSNVDLTVQEILLAASQHDVPKLRRLIRSNDKDGNPANVKDPETGFSPLHAAIAACEPDEAQTETNGVNGETSSASTEQKSLVQSAAETVKYLLQEGAIWNDLDLNDETPGCIARRLGLTELYEMIVDAGVRAELLLNRLDGYEPLSDDEDDQETGQGEDAANEPAAEEDQDEAPELVETTAADASAAEASTEGPGPDVTSSRYLDSNLTFTNDRLLDQDQNGVMMAWETEIMSRSAKKLLPTTGLRVMNIGHGMGIVDGFIQEQSPAAHHIVEAHPDVVAEMKRKGWHEKPGVVIHEGRWQDILPALVAQGETFDAIYYDTFAESYADFREFFSEQVIGLLEQDGKWGFFNGMGADRQISYDVYQKVVEMDLFEAGFDVEWEEIKVPKLEGEWTGVRRPYWVVDNYRLPLCKFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRX5</accession>
    <name>B0XRX5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_025170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025170"/>
    <dbReference type="HOGENOM" id="CLU_187039_0_0_1"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="PhylomeDB" id="B0XRX5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="71" mass="7862" checksum="83874EA772BF4644" modified="2008-04-08" version="1">MAAAWKAAGLTYNRYLAVAARAVRRSLKDGPRLAAERRGQSELRFAKWENGKQGEVKSIAETNQQAAQESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRZ0</accession>
    <name>B0XRZ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_025330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025330"/>
    <dbReference type="HOGENOM" id="CLU_2454283_0_0_1"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="89" mass="10380" checksum="6C1755673254D88A" modified="2008-04-08" version="1">MMYISSDFPTAITMRKTNVYEERSVGVYEHDSVSEAESRNGKHVGLAVHIQRQLGFDLCCMEDIVDSNTHWIMQFCCNVNRMEMTRRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS54</accession>
    <name>B0XS54_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_025980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025980"/>
    <dbReference type="HOGENOM" id="CLU_025711_1_0_1"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="PhylomeDB" id="B0XS54"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="269" mass="29249" checksum="E6B0F60A1110EF9D" modified="2008-04-08" version="1">MQVLLLGGHGKVAQKLTPLLLARSWNVTSVIRNPEHENAILALGKGARGKLSVLLSSLEDVKSDDDAKKIIDAVSPDYVVWSAGAGGKGGPERTFAIDERAAKHFLAASFASSCVTKFLLVSWLGSRRVHPSWMSDEDWASIRKVFNNVLPVYAKAKLEADEYMAALAARRKQSGGPKLQAICLRPGTLTDEPATGRVALGKTRGVGNVTREDVARVADQLLAREDTEGWYDLLNGEEPIEEAVERVAREKVDAVDGEDVDGMVKRFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSH5</accession>
    <name>B0XSH5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_027210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027210"/>
    <dbReference type="HOGENOM" id="CLU_053162_0_0_1"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="192"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="419" mass="50353" checksum="15A703C5C87D028F" modified="2008-04-08" version="1">MSRYDDYRSSSERMERTRERRYSRPPVIDRPRRSEEERFESRLHELDRYGPPARRSDRFYEDDHLLHNSGPLVTYERSRGDSPPPRPRLLRRQSSLDTFDRIPSRKLGEYYIRGHLPREPRAPSIPRRRPSRRHRETEYYEDIRIAEPDYYGDEEFRILQERDRYAAHPRRSTGRVREEVVEEVEYEKPYPRKGKTRMPRRLVHSLAIKKLGYPYEEEDDRITIQLALSKEQIDEVISLSREIRRQTETRTIYTRRSPSPIRARPRERTVERLTMETYSPRATQDTLIIERSPSRHRSPSRHYELSEKRVTRAVSRTRSISVHGRRHGLSSPVRMVERYDDQVDFDKRDTGPLAIVVRPRDSDDDLRELRRLEISERDEKIRNTQLALPSGEMEEITEVRKDRRGPNPRILRAMMATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT62</accession>
    <name>B0XT62_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GPI-anchor biosynthesis protein (Pig-F), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_018150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
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                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
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            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018150"/>
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    <dbReference type="OrthoDB" id="17366at2759"/>
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    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="297" mass="31827" checksum="2EB838826FDED716" modified="2008-04-08" version="1">MTSASPSPLRAANAASSAPVPPPAMKPSAPPVNILPTQLARTYSFVHPAALLAILATRFQALVADPVAEMLNTLPFLALLQVTYVMVCLPPAGSVLPSPPASPVSDGDEKEKEKEKEKEKEKEKRKLPLRAGKLPRKKNQTHAAGLSAKLTPALLSLILTFLLATPVLSLLLVLFGAPLTTHNAETVLCAAHMALLASTALIYVHGVDGAVWREVWAFARPADAVWGGALGTALGAWFGAVPIPLDWDRPWQAFPITILTGAYFGFAVGSVVCRSSWLFGKWLEFTPEQDDRDKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT63</accession>
    <name>B0XT63_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_018160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018160"/>
    <dbReference type="HOGENOM" id="CLU_032648_0_0_1"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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            <end position="102"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
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            <end position="304"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP53772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="554" mass="61658" checksum="19ED9F34F8CF46E3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU44</accession>
    <name>B0XU44_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_030280</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030280"/>
    <dbReference type="HOGENOM" id="CLU_069163_0_0_1"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="PhylomeDB" id="B0XU44"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="345" mass="39283" checksum="914429A773253477" modified="2008-04-08" version="1">MAESQRLVLSTPELLENILLYLDVQSLLTSAQRVCRSWTRLIQTSLRLQQALFFQPIPPEKCREKLLNPLLAKHFWNFFPPARDPSGVRECTYLLLSGPEASERRQKLLRCEASWRRMLVQQPPASLAYVQATHTRGGWIFKHYYLPCDAAPTTHWVHGQVQMDLIGLRMNMLYDLVFESLLGGLRRHWICWEAHMPPQFGPLVYLEEFMPLVEQAIQEADVVVIDHWRTIGAVAMPFTSSSSSTSSYFADRGPEAEQGHPVGSGTGLTPNLPIETLERAGSDVSRVYDGRSNLLSAFRSLQYPFLDWGVEANSTRVSGLACLELREEKFIPREQSSDEMSDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUI8</accession>
    <name>B0XUI8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_031040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031040"/>
    <dbReference type="HOGENOM" id="CLU_1204533_0_0_1"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="PhylomeDB" id="B0XUI8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25713" checksum="418703614A0A3936" modified="2008-04-08" version="1">MPSSLPLVDRALAIFVVSAVMMVISAVAVVLRSFVRLYLVQAFNWDDALMTRMLTIFHQSLFVVLGICCMIGTLSGVGHRMVEFVGLGALDSTYQIAIWSVMETGLGIIAGSLVTLRPLFRWFLDSNLSERHRRGTKRSDRQYPLSSLPDDPPKESRDPSYWRPDLPEEVPSVVTTISSPMVRSHLDDDHSSQEGLSVPEDSWARYQVNIHKTFQITTAPSCCQLSLILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV01</accession>
    <name>B0XV01_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRAP deaminase (Rib2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_032030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV01"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032030"/>
    <dbReference type="HOGENOM" id="CLU_016902_12_4_1"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="PhylomeDB" id="B0XV01"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="133"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="59097" checksum="265D5C07CA4D6190" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV28</accession>
    <name>B0XV28_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pheromone-regulated membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_021440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021440"/>
    <dbReference type="HOGENOM" id="CLU_007968_0_0_1"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="PhylomeDB" id="B0XV28"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="71785" checksum="239572D012EA983A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV30</accession>
    <name>B0XV30_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF21 and CBS domain protein (Mam3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_021460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
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                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
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                <person name="Whitty B.R."/>
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                <person name="Wortman J.R."/>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
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                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
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                <person name="Sundaram J.P."/>
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                <person name="Whitty B.R."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
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                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
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                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
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    <comment type="function">
        <text evidence="5">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
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            <location evidence="5">Endosome</location>
            <location evidence="5">Multivesicular body membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 5">Prevacuolar compartment membrane</location>
            <topology evidence="1 5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVF1"/>
    <dbReference type="HOGENOM" id="CLU_014574_4_0_1"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="PhylomeDB" id="B0XVF1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="126"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="225" mass="25122" checksum="5843B6BD0B35AD1E" modified="2008-04-08" version="1">MIFEAEGIKAGGGESWIPVCLPGFNSSGYLYMYVSFLDLRENSGTSASETTTEQSVAIILISPNKEGFFEMQEMRNSLVENPGCLGQTNSIRRWQQLEKNNSINIIKEAIDGGRPTTTDIVPGTVLHHFLYKSRANVQFTMSSYEPEFTSISRRRSIHAKHAHVKVHHCISQSASSFAWVTPIFELYCVASPNANRNALAQSASKVVQWVQREEERLFIIGGAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWB3</accession>
    <name>B0XWB3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_024210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024210"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="B0XWB3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000436">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="553" mass="59679" checksum="862B810B2A09D86A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWD1</accession>
    <name>B0XWD1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin C-terminal hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_024390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024390"/>
    <dbReference type="HOGENOM" id="CLU_228178_0_0_1"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="PhylomeDB" id="B0XWD1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="1616"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2508"/>
            <end position="2531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2087"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2531" mass="285845" checksum="83620844686DC986" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWG2</accession>
    <name>B0XWG2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_035810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWG2"/>
    <dbReference type="SMR" id="B0XWG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035810"/>
    <dbReference type="HOGENOM" id="CLU_015495_5_0_1"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="PhylomeDB" id="B0XWG2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="591" mass="64563" checksum="3A8BA0F2C6AD57A2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWH0</accession>
    <name>B0XWH0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_035890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035890"/>
    <dbReference type="HOGENOM" id="CLU_078264_0_0_1"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="PhylomeDB" id="B0XWH0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="term" value="P:translation"/>
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        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
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    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS15"/>
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        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
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        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
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        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
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    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
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        <property type="entry name" value="Ribosomal_S15"/>
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        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
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        <property type="entry name" value="RIBOSOMAL_S15"/>
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        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33920" checksum="65485784C8E7D463" modified="2008-04-08" version="1">MPPRFLSQPIFKAFTGSSHVHSPLAAFSLTPSKTSVRAGSAETRERRRHDPFLMAQSRQRKAANLSRQQALAREREESLGDPVESKPTPFIEELKGLKAPTSEDAALNHFISPEGLQEALEYSKSLTSPLENPDRETADPQLEKEAAERHLQEHRNAQEAIRRIININNGNTKDRTRLLIQKCIDTFGRHNTDKILPPKPTAVAQDSSTVHPKKTPRIGPDTGSPEVQVAILTAKIINLSRHLQSTNKDKHNKRNLRLLVHKRQKLLRYLRRKERGGPRWQHLIETLGLSDAAWKGEISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXA6</accession>
    <name>B0XXA6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_037390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037390"/>
    <dbReference type="HOGENOM" id="CLU_1277932_0_0_1"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
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        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_ZZ"/>
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    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="4">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="216" mass="24292" checksum="0BA6E6CCB90BAC98" modified="2008-04-08" version="1">MVELGKSPHTDWTNVSIAQLRSANFPIYVTFQEPGDLIVYPSATSHQVWNIGPMVTRVVWNVMHTSSMASFFDYIQPAYQRQCHTDTGRVPLIPLHALRDPAGLSAKELKLLLEIFERLVDDDDAGPNVPVKLVDTQGAVVECNYCGLTIWNRHLHCEQCGDFDLCLPCFVSGRSCKHITDYTWAELIPREDCQALIDATRKNADFLSSSNPRIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXU0</accession>
    <name>B0XXU0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_038550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038550"/>
    <dbReference type="HOGENOM" id="CLU_009400_0_0_1"/>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="PhylomeDB" id="B0XXU0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="101545" checksum="81A26087DDA64692" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY37</accession>
    <name>B0XY37_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_039520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039520"/>
    <dbReference type="HOGENOM" id="CLU_033097_0_0_1"/>
    <dbReference type="OrthoDB" id="5308502at2759"/>
    <dbReference type="PhylomeDB" id="B0XY37"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018830">
        <property type="entry name" value="DUF2434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10361">
        <property type="entry name" value="DUF2434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="483" mass="53657" checksum="F69E14097102EFEA" modified="2008-04-08" version="1">MTILHIRAATPYEPGDNATDVIVNEVHLNRTTLDLYNYTLYSNGTLSNGTDCYLAFQEFQPRMDENGTFVNGISCYAPIHGIGRHASIGMAFTAFFAVSMFLTMFNLQKHGRKYLPGRTMGRRLKWLWLLFVAACGLVSCIMTVDVDRSHIQGPSLILQSVFYTLMTPGLMAAVWEAVRHWASWQERQILDRDPYAFTKRSSRRRQESLLPILFYVFALANFFLTIPRSWTGIELQRSPELTALRAQPLATDLRFKIAGFMSLAGMLVICYSLEHSIYRYRAAPTSPLAQATFYLSASPPEFLLALILLGLKTGYAIAAAFDWSVSPLRVAVSQGLLYGLGVAPALLIIVLFNAVGFCELNEDKALIVQRGELDSALATDADLLGRKRWWESRWLHGGDRNRNRDRDRDRSSSREQLDRYVEMGILAPHGKGDGEDKDGSAGAAGAEAAPRVTTRTASDASSSSESGFVTVTVASPGQQRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYA0</accession>
    <name>B0XYA0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory particle subunit (RpnL), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_040170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040170"/>
    <dbReference type="HOGENOM" id="CLU_046003_1_1_1"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="PhylomeDB" id="B0XYA0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="72"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="280" mass="31162" checksum="0BAB40FD854DA8D2" modified="2008-04-08" version="1">MAHSVDLRSLVSELHNALNRKQLDAANNLLSQAKRTLLLQNALIPTPSTPSDLIALAREVLELGALASIRQTDAQGFTRYYQQLQPFYDLERDGAGSVKVDTKSSQRSKITGLYLMLLLSMGDSTSFHTVLEGLVEEASLQGKRVEDDLYIKYPVDLERSLMEGSYDKVWRETNSERVPSEDFALFSNVLVGTIRSEIADCSEKAYPSLPISNAKNLLFLDSEGAVIEFAQQRGWVLRDGRIYFPVEPEAAARSEKDILVASSTVIENTIGYARELETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYA4</accession>
    <name>B0XYA4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_040210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040210"/>
    <dbReference type="HOGENOM" id="CLU_102251_0_0_1"/>
    <dbReference type="OrthoDB" id="4186058at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="186" mass="20712" checksum="AE8D38255A9075F2" modified="2008-04-08" version="1">MPANEQRSPESHEEFSHTSSTTTTRSSNSAASEDVYVEDVSSRDSGYDGDIEVVKPYAIEEPEDEAPRHVPRLAISPAPNDAESWQGELVNSMQDLHCDSDYPDLRCRPSHRRGRKRKTPTVGAGNSVPGGRRQVYEAALDIQYEGPRASPKRLRRRSLRLKEDQRTPLSPRSPTETDSPASPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYS2</accession>
    <name>B0XYS2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_041890</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041890"/>
    <dbReference type="HOGENOM" id="CLU_405947_0_0_1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="PhylomeDB" id="B0XYS2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.10:FF:000007">
        <property type="entry name" value="Class V chitinase, putative (AFU_orthologue AFUA_3G07160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
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        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
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        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF337">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3 10" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760569" description="chitinase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="18"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="301"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="513"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP53018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="677" mass="75257" checksum="F51558BA175A706F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYU1</accession>
    <name>B0XYU1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_042080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYU1"/>
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    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="PhylomeDB" id="B0XYU1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="3">
        <location>
            <begin position="75"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="304" mass="33860" checksum="3137875FD4A1E7A7" modified="2008-04-08" version="1">MTNQNPAETLEQLRQLEQENGDLKTCLAIIRISEPISSSDAEKSNSSPSKRTSDVSAIDNPTPASLEADLTHYKELFAKLRFSYVEQVTKEKFLRAIVGDPPLVVGHNENVELEGQLAEVKAELKSRKEEVRIMIEDMEKMGRDLASRECLCPLWHEEALSIATGYKKVQLQMTQLSTLPESIENLESTIAGLRAKQVATMGTTSSQSLPLPVTLSLLAEREAELAALNRQLAAVQNVLPRKTREAEAMERELSVLERRRSEATAQAREAQRMKQEGKSDGLEELGRWYKSAEETLKSLVGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYY8</accession>
    <name>B0XYY8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_042550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042550"/>
    <dbReference type="HOGENOM" id="CLU_1128824_0_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="246" mass="28193" checksum="9B0FDDCEC45A9627" modified="2008-04-08" version="1">MTELPTPPASRQSSESPELQLKQSHEAESSAKALEMLDHSLERYLLLLDQHQKLQADLAKKLSSGFFSLAHANYTCPPGRRYGADYYDERMKAIRKMAIRSPPCAENKKSRSSRWMRRRTTSESRSQKQAKTRKRPTRKSTIRDRLTRVQHQNPTPQKSDLAFLTLSIGMVSWFPLLFAAPKGLSQKLWSNICPSWPVWLWRCRLWRERSSDCEVNYDEPTLPESHDSDSSAAVTLAPGCALTPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ32</accession>
    <name>B0XZ32_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_042980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Could act as an H1-type linker histone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042980"/>
    <dbReference type="HOGENOM" id="CLU_052897_0_0_1"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000383">
        <property type="entry name" value="Histone H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="10">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP53128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="206" mass="21427" checksum="B98BE9D944369AC0" modified="2008-04-08" version="1">MPPKKASTGATKKATSSHASYRDMIKDAILNLKERNGSSRQSIKKYVLANNKIAFASQAAFDSQFNKAIKAGVEKGEFTQPKGPSGPVKLAKKEPAAKPAAKKATTATKAAAPKKAAAKKTEKAEKPAAKATTKKAGTTTKKAAGRPKANTAKPRKASTAAPAVVDQPKVLSTTKSGRVTKTTAKPAEKAAKKKATTTKKAEKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZC1</accession>
    <name>B0XZC1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNF7 family protein (Fti1/Did2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_043870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043870"/>
    <dbReference type="HOGENOM" id="CLU_1315099_0_0_1"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="PhylomeDB" id="B0XZC1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="209" mass="22903" checksum="72A1C1B0CB7E1772" modified="2008-04-08" version="1">MVRKDPIFEARTNVKLHSNRLKKEAARAEATFKSEKAKADKAMKNREFQIARIHAASAVREKRRQVTLRAEAARADVIINELKAAQSTRDTSRTLALASRGLDAASKSVNLENLVSHANNFLARSEDFKIASSAIEDVAQGVSMQEYGAEGEAEVDRLMEQLADEAGVDMRLALDADAAPKEDVKEQKQADSELEDGLGARLRALRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZI2</accession>
    <name>B0XZI2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_033960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033960"/>
    <dbReference type="HOGENOM" id="CLU_1570257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="170" mass="18708" checksum="766F29E5FE62A8B9" modified="2008-04-08" version="1">MRHEGVKGFPHGGLVSGGRTNHRALRAAWGRQQRAPFWQESPACSCRPGVTETPAAEEGTRIPKVLQVLTRRLAPACLQELDTVCFLPGSCHMQIGVDIQVECSVGSVSAGRVPAIDGCSRCKWDNHMPPHRHQWAPRIRDMTVRGQCASSNSPFTDIQRFTVVTWSPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZK4</accession>
    <name>B0XZK4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-binding monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_034180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034180"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="PhylomeDB" id="B0XZK4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="605" mass="68691" checksum="383F645B6F3ACF25" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y093</accession>
    <name>B0Y093_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_035200</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y093"/>
    <dbReference type="SMR" id="B0Y093"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035200"/>
    <dbReference type="HOGENOM" id="CLU_000995_0_1_1"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="PhylomeDB" id="B0Y093"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="486"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="699"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="868"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP52357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="896" mass="101008" checksum="A9CAF45A457EAFCB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0X4</accession>
    <name>B0Y0X4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_058860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0X4"/>
    <dbReference type="SMR" id="B0Y0X4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058860"/>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0X4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP51865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="364" mass="39574" checksum="A9F77BFE6B7BA1A1" modified="2008-04-08" version="1">MATNTIVILGAGVSGLTTAYLLSQNASNSITVVAKHMPGDYDIEYCSPWAGANYLPVGKAGSPHERWERETWLALKELTEKHPEAGIHFQNTIVYNRVKDQGSPTGQWFSELVQPNPWYKDVVPDFKSIPADQLAPGIDNAQKFTSVCINTAVYLPWLVGQCRKNGVVFKRAVFKHVTEAASAHHSGKKADVVVNCTGLSSKKLGGVCDEKLYPARGQIVVVRNDPGAMFSISGCDDGEDELVYMMTRAAGGGTIIGGSYQKNQWDPLPDPNLAVRIMKRAVDLCPQLVKEGQGIEGLDIIRHGVGLRPLREGGTRIEAEKIDGVSVVHNYGHGGFGYQASYGCAAEAVRLVDDVLQRKRKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y131</accession>
    <name>B0Y131_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_059420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y131"/>
    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="PhylomeDB" id="B0Y131"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1003"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1051" mass="114222" checksum="B01071112E269076" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2T0</accession>
    <name>B0Y2T0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HypA-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_051860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2T0"/>
    <dbReference type="HOGENOM" id="CLU_019145_2_1_1"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2T0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="515" mass="58430" checksum="27F66F5213BF8524" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y325</accession>
    <name>B0Y325_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_052700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y325"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052700"/>
    <dbReference type="HOGENOM" id="CLU_018628_0_1_1"/>
    <dbReference type="OrthoDB" id="4150765at2759"/>
    <dbReference type="PhylomeDB" id="B0Y325"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002000">
        <property type="entry name" value="Putative heat shock protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046707">
        <property type="entry name" value="DUF6780"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20571">
        <property type="entry name" value="DUF6780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="235"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="739" mass="81088" checksum="A337EEC474E1EAB4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y345</accession>
    <name>B0Y345_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_052900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y345"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052900"/>
    <dbReference type="HOGENOM" id="CLU_1209560_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF4">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25049" checksum="D761B3CE8F33CC0F" modified="2008-04-08" version="1">MNEPLDLLGYQTRPLVFRIYLGDSSQKELSAEILYKIHRGNDEIVQSLPLRLRLTEKLVSQAQKLTYYYAGIVSYAILRPPPVTCAPAFPEGDGALPVIVGLHGAGVKADSVQVREMLDAAYGTCAWIISPSGVTPWSGDDWHTWGAGDVEAAVDAIARWIDSTGWDKVRVSQKEWIVVGHSNGGQGAWFLATHYPDKVIAAAPVSGYSSIERFRASALIRALEVKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y380</accession>
    <name>B0Y380_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_053250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y380"/>
    <dbReference type="HOGENOM" id="CLU_2003388_0_0_1"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758180" description="Derlin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13418" checksum="9C80FEBDDC83A0E3" modified="2008-04-08" version="1">MLVLTLVMAGWPAALSEGMGIIAAHLYDFLTRLYPTFGGGRNYLTTPAFVRRFFAAYAPRGEYRAYGTAYRPAGQNPPPSSSGWVSSFQSSWGGRGPGRRLGGPRVRGSTVYFLSVFADAVDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y438</accession>
    <name>B0Y438_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_056400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y438"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056400"/>
    <dbReference type="HOGENOM" id="CLU_096567_2_0_1"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="PhylomeDB" id="B0Y438"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="62"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="219" mass="24721" checksum="AE470E6F80418AB1" modified="2008-04-08" version="1">MWFLVLKLLRIGVKEAKKHKAKKNAANTSTIDPENISLDRNTNMPFPADSTPARNPLITLLETILRFIQFVFGLTVIGLYGRDLHDGDKAAAPAKWVYAVVTAFLAVMTATVYLILPFVMKGRTPVARRARVQLPLFIWESVLCILWLTLFGIFGKMYIGNYSEGDMVTRMRHAVWVDLVNLGLWIVTMGWVGLRWWRGVKGGQEGGEREMEDVEKAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4B8</accession>
    <name>B0Y4B8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_057200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057200"/>
    <dbReference type="HOGENOM" id="CLU_044099_0_0_1"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4B8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000003">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="336" mass="37704" checksum="3E676DB37BF5E227" modified="2008-04-08" version="1">MDQRKKKRKVLLMGKSGSGKSSMRSIIFSNYVAKDVRRLGATIDVEHSHVKFMGNLTLNLWDCGGQDAFMETYLASQRGNIFSDVAVLIYVFDIESREVERDLDTYNAIISALKEYSPNAHVFCLVHKMDLIQAEHRQRIYEERSALIRSRSEQFAIDTFGSSIWDQSLYKAWAGIVHKLIPNLTVIERFLTAFAKRIDAEEVILFERSTFLTVTSVSSEIGDMNPIYDRHERLSNIMKAFKHCAARNTHTTPATAGFLVMHTKTPQFNVFLGRFTDNTYIFMVVPPGEAAYNCAVLNTMLAREGFSKAAAAGYGDGFPLPASDPPEANMANGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4E6</accession>
    <name>B0Y4E6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter of unkown specificity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_057540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4E6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057540"/>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4E6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000285">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000294">
        <property type="entry name" value="MFS transporter of unkown specificity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="514" mass="55924" checksum="412F32BA1E4EC654" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y534</accession>
    <name>B0Y534_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_071240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y534"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071240"/>
    <dbReference type="HOGENOM" id="CLU_060605_0_0_1"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="PhylomeDB" id="B0Y534"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF8">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14085)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28509" checksum="EB9B5D5C83C81D68" modified="2008-04-08" version="1">MAPKSGVLVPLYIYPLSTTTWAPLYDAITAHPDLDFLVVVNPNSGPGDLPSPNKDYAREVPKLNAFPNVYTVGYIRIHYCDKPLENVYQEIDRYASWSACDGLGLGGILLDETPNHYSEAREEYLRACTGFIKGNQGILRDRMVVHNPGTPPDAGLANTCPDLILTCEEPYERYRSDEVQHRLAELPYDRVRCGYMINAVPVGELTGLVRELRDRATYVFATEVEGDFYERFGPTSWKQLMHALKRDSDSETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y559</accession>
    <name>B0Y559_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_071490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y559"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071490"/>
    <dbReference type="HOGENOM" id="CLU_022048_7_6_1"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="PhylomeDB" id="B0Y559"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000051">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="170"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="495" mass="56418" checksum="759916D169F8D9F1" modified="2008-04-08" version="1">MAFVLSPEIDQPTADLLIQLQLQDAGLYFESSKGKSRDPTDEELAFQLQNEELEIISQLLADRRMATSFAAAVQADGCIVAVNQVEEDNACKDRDIARQWTENGCLESSANFESNPATLDDETLAKLQILYVSGMEGYHNIGVMGGGDSETEQAESSAWAARRTGQSLSPVRRCVACREQTEFVNVARVPCQHEYCRPCLEDLFKASLTDESLFPPRCCRQPINMTIARIFLKSDLIEQYEEKKIEFETPNRTYCYYSECGAFINTSHINGEVATCPCCGHTTCTNCKGRAHMGDCPNDTAMQQLLATAQENGWQRCYSCWRMVELDHGCNHMTCRCGAQFCYNCGAQWKNCRCEQWDERRLLARAYQLIDREEDRPLAANPPPDIDEPQLEGHLAPETDETHLESQEAQPEQADEESHAAPEASASPCFQTPRDILVARTIQELRENHECVHDRWKYIRGPHRCEECSYYLREYIFECRQCRIQACNRCRRNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y561</accession>
    <name>B0Y561_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_071510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y561"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052518">
        <property type="entry name" value="CHR_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43663">
        <property type="entry name" value="CHROMATE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43663:SF1">
        <property type="entry name" value="CHROMATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="382" mass="41162" checksum="2EB284516FFFE62C" modified="2008-04-08" version="1">MVSVSEPSQSTATNNGNNRIGTEQSDSMDIEAQSASAKVPPGEIKKSVGSEEPADPGLQDNTNVPRLPLLRLFWFFYNFGLFAWGGPVAQIALIKDRLVIQDKWITLTRFQRVFSVYQILPGPEAAELCMFFGCLSAGRIGGIVAGLAFILPGFLLMLLASYLYSLAGLENPYFNASFRAVQPIVSAMSLRSSYPEKNRINADSSFRFISLGLYGIIYSFIARRKWVIAGSLFVLQYVAYAIYVVYRGVPSPVSLALGVAETPSLPNLLALGLVAGCLSFGGAYTAIPFIQVEAVLKGSWLPAHIFLDCIAIGNMLPAPLVIFATFVGFQGGLVHGGLGTAFAGAVIITLGMFAPCFIFTIAGHDLLEKLVRNKVRPSLNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y579</accession>
    <name>B0Y579_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N,O-diacetylmuramidase</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lysozyme CH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_071680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y579"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071680"/>
    <dbReference type="HOGENOM" id="CLU_044973_4_0_1"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="PhylomeDB" id="B0Y579"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF4">
        <property type="entry name" value="GLYCOSYL HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758216" description="N,O-diacetylmuramidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP50828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="234" mass="25194" checksum="413E3AFF43311E0B" modified="2008-04-08" version="1">MQFCIPWGVLLGLLSLASAAATQNGTEGIDLFEVHLPVNWKGAVANGVKFAFVKATEGINYRNLRFPFQNAGARAAGITHGAVHFAAAAESSGADQADFFIEHGGNWTADGQTLPGVLEMEGNLAGKLCHGMTPTEITDWMLDFSHRYKFRTGRTPILFLSAGWWAKCAGNNATFGAEHALWLANWAEEMGPLPVGWQAAKFWQYAGWSENGGEANVFLGSSKDLVKLAMGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5I0</accession>
    <name>B0Y5I0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal biogenesis protein Gar2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_063470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5I0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063470"/>
    <dbReference type="HOGENOM" id="CLU_025741_5_1_1"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="262"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="509" mass="56636" checksum="C8F063F5D01D614A" modified="2008-04-08" version="1">MGDQKKSFPHLVFGKGLIAVLQPSIQHTTTRNMAPDKKDKKRKAATTVTADSPAKKTKKVEAKPSEAPKETPKSILKKNKKDGPATEQNSTSKVKVNGEPTRQVKPRKRAADFLSDDESEPEVVASEPKADTEEKKQPSKKKSKKEDGTPAPATKAKTSATAAKPKATKAKKPEPVVEESDDEDNQQVPVVSDDSSEDEEDDTLDDQTAALIKGFESSGDEDESGDEGFDPDQPVPKIPDSKKAKRKILKKQKKHDEPEVPGTVYVGRIPHGFYEHQMRAYFSQFGDITRLRLSRNRITGRSKHYAFVEFASSTVAKIVAETMDNYLMYGHILKCKYVPSDQLHPEVWKGANRRFKRTPWNRIEKKRLEKGKTREQWSERIEREQKRRLAKAEKLKALGYEYELPQLKSVDEVPVQEETKAIEAADTTADEPKKAIEAPSAQESKEETTVDETPKKLKKEKKASQSTPKQGTPKQDGEKASTKKGVNGAAASPATKAGTKDKKAKKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5K1</accession>
    <name>B0Y5K1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_063670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5K1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063670"/>
    <dbReference type="HOGENOM" id="CLU_174153_0_0_1"/>
    <dbReference type="OrthoDB" id="4510053at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758651" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="99" mass="10858" checksum="D1934D5E99081BEB" modified="2008-04-08" version="1">MGPKAYLSLLLLLTVAIACAAPIRRPISALHTRRDPGPDAAAESLDSLLPSPLDLPLPKPEPLDVDSMLAHSPLSDFYKIIKEEVKVDMPNMRHKNRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y607</accession>
    <name>B0Y607_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_065240</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y607"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065240"/>
    <dbReference type="HOGENOM" id="CLU_021152_6_0_1"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="PhylomeDB" id="B0Y607"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="13">
        <location>
            <begin position="390"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="13">
        <location>
            <begin position="486"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP50192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="567" mass="61841" checksum="3F1C1B672F25B74C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y681</accession>
    <name>B0Y681_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_065980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y681"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065980"/>
    <dbReference type="HOGENOM" id="CLU_048345_2_0_1"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="PhylomeDB" id="B0Y681"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="318" mass="35230" checksum="436AD9DCD5C32390" modified="2008-04-08" version="1">MERPNKPSAIGVAASLPQPTITFRQNKIEATLPTGESVTVHLYGATVTSWKLANGREQLFMSETAHLDGSKPIRGGIPVVFPVFGPPPPNHATSSLPQHGFARNSNWEFLGKSSSESLGKKDSDDSVKLDFGLSHTMLSEEFRKAWPYEFGLLYSVTLSKEGLETSLQVQNKGNQNFDFQVLMHTYLSIDDISQIRVKNLESKTYIDKTQNATTHTENSPALEIDKETDRVYRALDPKVPIIVASAADDKPIFSVTREGLNDVVVWNPWIEKAKGMADFSPDDAYKKMICIEAGSVASWQTLEAGESWEGSQSIRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y685</accession>
    <name>B0Y685_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_066030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y685"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066030"/>
    <dbReference type="HOGENOM" id="CLU_010228_0_1_1"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="PhylomeDB" id="B0Y685"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="144"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="556"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP50270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="690" mass="77129" checksum="A5CB4CEE08EBF496" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y691</accession>
    <name>MOCOS_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="1">MCS</shortName>
            <shortName evidence="1">MOS</shortName>
            <shortName evidence="1">MoCo sulfurase</shortName>
            <ecNumber evidence="1">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hxB</name>
        <name type="ORF">AFUB_066090</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="1"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y691"/>
    <dbReference type="SMR" id="B0Y691"/>
    <dbReference type="EnsemblFungi" id="EDP50276">
        <property type="protein sequence ID" value="EDP50276"/>
        <property type="gene ID" value="AFUB_066090"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066090"/>
    <dbReference type="HOGENOM" id="CLU_010913_0_0_1"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="PhylomeDB" id="B0Y691"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000369379" description="Molybdenum cofactor sulfurase">
        <location>
            <begin position="1"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="657"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <sequence length="843" mass="94161" checksum="1109FA5E1C1715BC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6C1</accession>
    <name>B0Y6C1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_066410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6C1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066410"/>
    <dbReference type="HOGENOM" id="CLU_100997_3_1_1"/>
    <dbReference type="OrthoDB" id="2820488at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758232" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="167" mass="18549" checksum="500FAA0F55A1D6F4" modified="2008-04-08" version="1">MRLTSIVLFSLVSLGFARDPSDITHSPNRSKAKGAQLESYCPGQDADEDLQREIFNQFIQTLYENKNVPEAFETYVDPDLTEHGPYEQSRDEVVESLSQIIPTSTFTVVHSSYGGDIGFVHVRIGDEGAPPAAALADIYRMDGTCIVEHWDVLQNLPENSTNPNALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6H8</accession>
    <name>B0Y6H8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall biogenesis protein Ecm15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_067010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6H8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067010"/>
    <dbReference type="HOGENOM" id="CLU_137479_0_0_1"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6H8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="115" mass="12643" checksum="599A2E8C3748A45E" modified="2008-04-08" version="1">MTPADIASIPTPPHCTADFCLIPIGTSSPSVSSQIADVQRLIEKSGLKYVMHSAGTTLEGPWDKVHQVIGQAHMLLHQQGIVRIQTDIRVGSRTDKEQSFEDKVNKVRQLLAQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Z6</accession>
    <name>B0Y6Z6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_068680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD finger protein ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ING_fam"/>
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        <property type="entry name" value="ING_N_histone-binding"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="588"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="332"/>
            <end position="344"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="571"/>
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        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="615"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="601"/>
        </location>
    </feature>
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        <location>
            <position position="605"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP50531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="647" mass="69120" checksum="9D00F920695C1A04" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7F5</accession>
    <name>B0Y7F5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c oxidase assembly protein cox15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_073630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_017627_4_2_1"/>
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    <dbReference type="PhylomeDB" id="B0Y7F5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP49336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="522" mass="57815" checksum="7631CA8C06F8861C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7G9</accession>
    <name>B0Y7G9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromatin remodeling complex subunit (Rsc9), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_073770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7G9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073770"/>
    <dbReference type="HOGENOM" id="CLU_008152_0_0_1"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7G9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="402"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="685" mass="78528" checksum="CAA4F005B490A075" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y833</accession>
    <name>B0Y833_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_075940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y833"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075940"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B0Y833"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="39"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="408" mass="43468" checksum="4D8F1ACE37C3F253" modified="2008-04-08" version="1">MATQAQSSSQNGMIAAESKLEANANPAAKPSFPEGGVRAWSVVFGASIALGCAFGYLSAFGNYEAYYSEHQLAQKTASEIAWIGSIQIFLQYITSLISGSLFDLHGAKILLILGSISFVFSIMMTSLCRKYYQAILAQGILGGLSTGFIFTPSLAAIGHYFQKKRGLAIGICAAGSSLGGLLFPIALKHALYSRRLGFGWGVRVVGFVVLGLLAIACTLVRERLPPRKGRFFLLRAFLQPSYSFLVAAVFLSFWGMWVPCFFIVSQRRLAAREDHTGIFGGRFGRLNMLVCVYAANSIMLLGWIRITTAAGLIAWAAVFGFVSGAIISLYPVSIAQLAPRPQEIGTYMGQASAVVSVAGLTGTPIAGALIRSYGYEAAALFAGLSMVVCTCLAAVSRGFYAGKLLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y905</accession>
    <name>B0Y905_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_079190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y905"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079190"/>
    <dbReference type="HOGENOM" id="CLU_1992110_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="125" mass="14250" checksum="D05B98917125C4DD" modified="2008-04-08" version="1">MVRWVRHGHLPIDILFSDMFENRLWRVSVQWPSRSVLNLERTTSEAGRVTATITTMATSRVSGSSVQFSPESLLHTNQHQESLLSPRLCYTEKTREIALAPKISPSLIGFCPTSSELREPHLYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9L2</accession>
    <name>B0Y9L2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_081430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9L2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081430"/>
    <dbReference type="HOGENOM" id="CLU_031561_1_0_1"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9L2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="317" mass="35422" checksum="FB5DD664A453BDC9" modified="2008-04-08" version="1">MVLVDRLIPPVHANGLQRIRDSWKMPSDSITALFPWPKDFSQGITPVQCHSHNDYWRNVPLFDALAAGCVGVEADVWLDKTSNNLLVGHRASSLSADRTLQSAYIEPLTTILTQINQGVNATVPRSGVFETFPNASLTLLIDVKTDGHTSWPVVMNQLAPLRAGGWLSHWNSTGDGLAWRSIIVVGTGKTPFELINADAEYRDVFFDAPLDQLADDASFTANNSYYASASLKEVVGTIWPWGPSRHQKDIMKRMIDTAAARGLVPRFWNIPGWPVRLQMKLWRFLMESGIGILNVDELFEATQWIRDWCTGEGKMQC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA89</accession>
    <name>VPS10_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Carboxypeptidase Y receptor</fullName>
            <shortName>CPY receptor</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Sortilin vps10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Vacuolar carboxypeptidase sorting receptor vps10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">vps10</name>
        <name type="ORF">AFUB_083810</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Cycles between the Golgi apparatus and the prevacuolar compartment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA89"/>
    <dbReference type="SMR" id="B0YA89"/>
    <dbReference type="GlyCosmos" id="B0YA89">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP48932">
        <property type="protein sequence ID" value="EDP48932"/>
        <property type="gene ID" value="AFUB_083810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083810"/>
    <dbReference type="HOGENOM" id="CLU_000700_0_0_1"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="PhylomeDB" id="B0YA89"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000006">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000676">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52072">
        <property type="entry name" value="VPS10P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-0675">Receptor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407504" description="Vacuolar protein sorting/targeting protein 10">
        <location>
            <begin position="23"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1357"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1378"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1410"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Vps10p 1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 3">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 4">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Vps10p 2" evidence="3">
        <location>
            <begin position="678"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 5">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 6">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 7">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 8">
        <location>
            <begin position="1145"/>
            <end position="1155"/>
        </location>
    </feature>
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            <begin position="27"/>
            <end position="533"/>
        </location>
    </feature>
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        <location>
            <begin position="541"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="10CCb cysteine-knot 1" evidence="3">
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            <end position="668"/>
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        <location>
            <begin position="678"/>
            <end position="1199"/>
        </location>
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        <location>
            <begin position="1207"/>
            <end position="1266"/>
        </location>
    </feature>
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        <location>
            <begin position="1268"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="967"/>
        </location>
    </feature>
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            <position position="1265"/>
        </location>
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        <location>
            <begin position="541"/>
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        <location>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1207"/>
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        </location>
    </feature>
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        <location>
            <begin position="1233"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1268"/>
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        </location>
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    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1275"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1487" mass="166459" checksum="B89476E2092F5D29" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBI9</accession>
    <name>B0YBI9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1857 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_086760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBI9"/>
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    <dbReference type="HOGENOM" id="CLU_1124300_0_0_1"/>
    <dbReference type="OrthoDB" id="2320332at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27192" checksum="D3486EFE62E6918B" modified="2008-04-08" version="1">MAIPSNNIAFTAPINPPGADPILTRSQIWNGLLFKIRSAETFVPAGIQSTTVLSESVDEAGNPVTLREVVFRADQRRVKETVTAHKDSRVDFVQPDGSTISNIVSEGAAGELYMTYAFEWRHPGASEEELAALREREKMMSKGAVEEMEEHLTYSFDGHADSPHKIGSIEKAIPTSVPFYSIHLYYPPRSMIGNTGSCHASECRALTDRMKPSTLLVTFPREQRCLAPKRVVSDFGACTMENASSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBJ9</accession>
    <name>B0YBJ9_ASPFC</name>
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        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_086860</name>
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    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_087059_0_1_1"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="PhylomeDB" id="B0YBJ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27208" checksum="33F1DB121A892A1A" modified="2008-04-08" version="1">MGLIEGLQAALDYLENPTALTATSVSMCLCWLATYAGMVRKSFQDRSYSMPLMPLCCDIAFEFVFSVLYPPTEAPILQYVFGSWMAGSVMVVFATIRFMPNEWKHAPLVQQNILSILAVTILGWMTAHLALVAQFGADDGSAWGGCLCQLLLGAGSLCQLIVRGSSRGASFFIWLSRFLGTNLGVLYFTLRFRHGHVIWHSPLAWWSSVIAFLIDSCYGILLWHIRQAEGRDQQQRKAGSEIGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBS2</accession>
    <name>B0YBS2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine-rich secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_087640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087640"/>
    <dbReference type="HOGENOM" id="CLU_045407_0_0_1"/>
    <dbReference type="OrthoDB" id="4662630at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758390" evidence="1">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="343" mass="36861" checksum="7C0A4BC7C184D217" modified="2008-04-08" version="1">MKTLALTLAALLLQAPPLQAKMYRQNILTFEVSNDARINGQKIEYNDPDCDQGMQCVVTKTCAAQGTGPTLSADKKHFACCLAGQRLLGSPETAFDCCADGHDLAGSAQTGYHCCPTGYSFDGQQCKQVCKNGRLMVNGQCVCPEGTAEANDGSCQAKTQTMCTSGLESGKCYTFTAENGNRLGLRNDGVYYAAPDSMVQRYGKFQLCSDEKCTPGRAINPSDKTYIKDVYGDVATGAHAGQWLNNAQNGAHIGRTPTFANAGQFVLSKWPCGKYCLGGFAAGIGPACPAEIPAMTFYSQDPQMCVPFELTEVPCDIKANVNNCIWKNGDQCCNKVDCTWRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCK1</accession>
    <name>B0YCK1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_090480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090480"/>
    <dbReference type="HOGENOM" id="CLU_124520_0_0_1"/>
    <dbReference type="OrthoDB" id="4449122at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="152" mass="16692" checksum="9D429638B770F8E7" modified="2008-04-08" version="1">MVKFGPTVGGNGGAEFKSFRERPVEQLDVWYGNGTGDNVNKYTILRGLRIRWAGGEQSRPIGYCPDEEEARVLHTSFDSERNGDDLLESMDIYGSASRVDSLRLVTKDEMDHFEAGGVGGDKCAQPANGRKLYGLYGRAGDDIDKLGAVFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCP9</accession>
    <name>B0YCP9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_090970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCP9"/>
    <dbReference type="HOGENOM" id="CLU_015166_3_2_1"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="PhylomeDB" id="B0YCP9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990616">
        <property type="term" value="P:magnesium ion export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="225"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP48380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="378" mass="41623" checksum="F6EA025226C7054E" modified="2008-04-08" version="1">MRRENGAVRRDALMDEEEEPRPPYLHAMLAGGTGGTCGDMLMHSLDTVKTRQQGDPSFPPKYTSMTSSYATIYRQEGFFRGLYGGVTPALLGSFPGTVIFFGTYEFTKRWLLDAGINANVAYLSGGFIADLAASVVYVPSEVLKTRLQLQGRYNNPYFNSGYNYRSTSDALRTIIRQEGFSALFYGYKATIFRDLPFSALQFAFYEQEHRLAKEWVGSRDIGLGLEILTAVTAGGMAGVITCPMDVVKTRIQTQQNPDAVKPSSASSKGPVEHASTKETLRQHTSNQTTSSLRTRSRPISTGGASTSVRPPGTPRLDTSSFFTGLKVIYQTEGFSGWFRGVGPRGVWTSIQSGTMLVMYQYLLKQLEAWQTTGETGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCQ0</accession>
    <name>B0YCQ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_090980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090980"/>
    <dbReference type="HOGENOM" id="CLU_041452_0_0_1"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="PhylomeDB" id="B0YCQ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="362" mass="39960" checksum="B6CBCB1750418BF8" modified="2008-04-08" version="1">MSNGLNWLKKLRRAEVNDLAHAAGLEDYADYSNKDALAIALNKYLQDNQTILINVPELKEYWTRASSTSPARTSPVKKAVGVDVTPAPKKVAPAGRKATPGTTRRRQTQPKKEEVEVTDDSEASEASEASTPDQATSPVTKTPARSQIAAESPLSPALVTDAIDRQTAEWREHINDAWVRSGVQESSNWVRSKMSSVRAVETIVMAVEGAFLMKDLIPIRYLTTIPAVPAINSPEFALRVPDLFMLVDGAFWAPFSLWLLTGYLLPLLFAYFFNISLQASGSSVPETRKGHKTRPEFDPLSFNIAKAVIAYVVYAQHFNFMGLYSNFSIERVNVSVPFHWPGMLTTAAIGTVGTLYEAILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD10</accession>
    <name>B0YD10_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_093880</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093880"/>
    <dbReference type="HOGENOM" id="CLU_046802_1_0_1"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="PhylomeDB" id="B0YD10"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758884" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="23"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="272"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP47544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="325" mass="36034" checksum="D55E3B23C89E203C" modified="2008-04-08" version="1">MYYPGINSLLLWLLCFAPPGLAYGRSSESPPGPNAILLSRVQSLTLRANRLTSSRRVSPIPQLKCVGPSKTICDKYKIETMRCTNAGYDYDEEDVQWTCTAQLPEEFMLGATDVICEGYRNADDKWVLKGSCGVEYRLLLTERGESRFGRIQEDDMRSIPLATKGWRRGMDALVDLIFLGFWAAVLVMIFWPMVRSCFGLRGRRGRTNVGRGWGGFWGGGGGGGGDGGGNDYGPYPGPPPPYSSFPDNSSCSSQPGWRPGFWTGAAAGGMAGYEMGRRSNRHDRPSSSRWFDDREPWRESNTQPRSPPRFSATTESTGFGSTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDA8</accession>
    <name>B0YDA8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_094900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094900"/>
    <dbReference type="HOGENOM" id="CLU_015092_1_0_1"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="608" mass="65560" checksum="AA2B2C8E7DD2FCFA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDK1</accession>
    <name>B0YDK1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_095870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDK1"/>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_1"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="PhylomeDB" id="B0YDK1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="127"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="524"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="582" mass="63159" checksum="7BCB26CCB7F00348" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDU3</accession>
    <name>B0YDU3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_096800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096800"/>
    <dbReference type="HOGENOM" id="CLU_043835_2_0_1"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="PhylomeDB" id="B0YDU3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760634" evidence="3">
        <location>
            <begin position="23"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="329" mass="34984" checksum="7AFF2E7B2E2AA7F3" modified="2008-04-08" version="1">MLKLSIMSMTVLLFFQSRTTHATGAVPTAMTPSSTAPHATHTVKVGPKENPHQYSPHNITAAVGDVIVFEFYPRNHSVVKADFMAPCVPAAGEIFYSGQFNTFKENNHGQLEGEPPTWSLVVNDTEPTFFYCTAVDSCLVNGMVGVINPNETMTWEAQYAQAQQYPYMLVPGQSPPAEGTGYLSSGSNAHKKSSFGGGAIAGTVVGGVAFVAILVVVAITLCRNRERQGSSSQVGRMERTAHWARFGGHGEEKSEQGFAASSSVGGHGTLSLSSGASPPAVSPPLQNVGSSNWESAMKQQPPQEIRQPSELEATNVVGGTPGGMYYGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDX0</accession>
    <name>B0YDX0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation diffusion facilitator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_097080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDX0"/>
    <dbReference type="HOGENOM" id="CLU_013430_10_1_1"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="PhylomeDB" id="B0YDX0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="235"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="538" mass="61076" checksum="8E92787C7F65801B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDX7</accession>
    <name>B0YDX7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_097150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097150"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B0YDX7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000088">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="28"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="438" mass="48827" checksum="897B1267E4F2C51B" modified="2008-04-08" version="1">MSSTPCINLLKGSPATALLPVQRLSDAAVSALSKPEVTVTGLDYGPDEGHFPLRTHLAEWLTAYYKPSQPIQADRICVTGGASQNLSNLLQVFTDPSQTRCIWMPQATYHLAFRIFEDAGFHGRLRAVPEDEEGMDVKFLEHALANDEAIADRVQRAKYKRDERYRKIFNHVIYCVPNFSNPTGVTMSLRRREALVRLARRLNGLVICDDVYDFLHWPAPHSSNNESTWSSMLPRVLDLDRTLDGGPRDSFGNVVSNGTFSKIVAPGCRVGWAEGEPQLVYGLSQVGSTVSGGPPSQLMSTFIDEMLQDGSVTKHIREVLIPAYSRRHSIMVSAVKERLSPLGVEIHADPSDPLHAGGVFVWVRLPWPLTAHNVTERALREENLIVGNGDIFVVPGGQYSSQHECLRLCFAWEDETDLTEGVRRLERVLIRMVNEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE42</accession>
    <name>B0YE42_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_097770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097770"/>
    <dbReference type="HOGENOM" id="CLU_1395998_0_0_1"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="PhylomeDB" id="B0YE42"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="195" mass="22312" checksum="8ADC70A72352F7E0" modified="2008-04-08" version="1">MDSVKQHADKTPLPPDSTELGLARSDTSLTIETEYVRMLLELQDIHWLYNFMASLAAWMLLAGYLVIPGTFTSLQKSDTITNKVAQNEAEKAVLKTIQNPPLVAIAWVLLSIGVATMSFLFYRWRRNYLWLISRLFMGKQSNAPQYGSRPVDNAHQYLHSEEQMLVDHGSPYSRSQRTTCRFICWANGRLQILET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEB6</accession>
    <name>B0YEB6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_098600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098600"/>
    <dbReference type="HOGENOM" id="CLU_022048_5_0_1"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="PhylomeDB" id="B0YEB6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP47260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="333" mass="36658" checksum="8FB7345FE652E553" modified="2008-04-08" version="1">MPSITLSSFISGLIHSRAEEERLHASDVEKIAPLGAASDKKAISTGARRAASRRNMDVRPAPGKSDLHLQAHIAGLKNLCVFPRLGVIDNMARLYQGIRKKERCTVCFNSESIKNVEILPCQHIYCDYCFSRLALTAMANEQLFPPRCCSQMIPTEQVLSKLTEKEKALFKLKAREYATSARERRYCPAMKCGKWIPLEKLEGQSTTQLCPYCGTAICPGCKDKAHAPGKCSFDPGLTEFLELARTQGWQRCFHCGAMVELNEGCPRITCRCGADLCYNCGGPWLICHHNALGNVIAECQTGAPLGDGMGTHDAVELAAIVAAMKFAERELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0YED2</accession>
    <name>B0YED2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-guanosine(34) queuine transglycosylase</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_098770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YED2"/>
    <dbReference type="HOGENOM" id="CLU_022060_1_0_1"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="PhylomeDB" id="B0YED2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002099">
        <property type="term" value="P:tRNA wobble guanine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="236"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="385" mass="42442" checksum="0AC0F01FDA5AAFFB" modified="2008-04-08" version="1">MPVATQASLKGLTYDQLKQTGCMLCLNNTYHLGLKPGQEVLDQVGGAHKLQGWDRNILTDSGGFQMVSLLKLAKVTEEGVRFLSPHDGTPMLLTPEHSISLQNSIGSDIIMQLDDVIATTSPDHARIHEAMERSVRWLDRCIDAHKYPERQNLFCIIQGGLDLELRKQCCAEMVARDTPGIAIGGLSGGEAKEEFCKVVDTCTGLLPEHKPRYVMGVVSTRWPIRLAVSFIDAAQGYPEDLVVAVALGADMFDCVWPTRTARFGNAVVPSGNLNLRHKSFAEDFRPIQEGCSCSCCRPRDQGGLGITRAYLHHLAAKETVGAHLLTIHNVHYLLNLMGSARQAILEDRYPAFLREFFDNLYGDKAKFPEWAVTALRGVGVDLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEU1</accession>
    <name>B0YEU1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Toxin biosynthesis peroxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_100370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100370"/>
    <dbReference type="HOGENOM" id="CLU_852609_0_0_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="PhylomeDB" id="B0YEU1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760653" evidence="8">
        <location>
            <begin position="17"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="67"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="324" mass="36980" checksum="4D21A668C62F6993" modified="2008-04-08" version="1">MRTLILVFLWLTAVSSYPRGIDWDYAIAYHQQVLQGENDRGFGLNEPFIPTPSHILPEKKPFYIDETVHYYERHFNGSGENGEYRRSSCPAVNALANRGYINRSGRNITYAELAHAVRKVWNFGDDNVILPPEESLVLHSTNSFPQSMLVLAPTFAMHGWPETIDLDYFNARYCSRFLEEYELTLAQDDLVQYVINCPAAPTRNDRAVGDNINLNMTLFESLLSFSKDGETLSLEDLAEHHHLRHNQSKAENPNFVFGNQGAICSLAQYTNMVGVLGKFGKHGRTTLFIDDVKTFYLDEDIPRNYERREAPVCCPSPRWTPSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEV6</accession>
    <name>B0YEV6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TfdA family taurine dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_100620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100620"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="PhylomeDB" id="B0YEV6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000007">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF29">
        <property type="entry name" value="FAMILY TAURINE DIOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="84"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="350" mass="39240" checksum="5E459CF728B1DEA6" modified="2008-04-08" version="1">MPDNSITKMTAKEVQLPSKPANLPHLNYHTPRGVSPLESVRAAGLEYPNYTPFKLPNLTLHPFTDRGHYADPSKSRLLSAATEIIHLTPDIGTEIAGLQLTALTPAQKDDLALLVAERGVVFFRDQDMDVHEQIAFAAYFGELHIHQMAGIIPDLPWVHPIYKDRTAVNGRSHQIWHSDVSYELQPPGLTMLRMDTLPAAGPGGSLAGGDTVWASGYALYESLSPKLRAFLETLEAKHSGLEQAEKALKTNGCLRRDPIETIHPVVRTHPVTKWKTLYVNENFTKEIIGIEKRVSDALLDTLYRTIAEAYEYQVRWKWTPNAVAIWDNRVTFHTGIFDYCMSTPLFYGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF00</accession>
    <name>B0YF00_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_101080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101080"/>
    <dbReference type="HOGENOM" id="CLU_000211_1_0_1"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="PhylomeDB" id="B0YF00"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="9">
        <location>
            <begin position="17"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="1993"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="8">
        <location>
            <begin position="2339"/>
            <end position="2374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="3086" mass="350432" checksum="90813DE06DBDDDD0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF82</accession>
    <name>B0YF82_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_101880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101880"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="PhylomeDB" id="B0YF82"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="250" mass="27578" checksum="C3EDF441C82AF95E" modified="2008-04-08" version="1">MPTQHRILALVYNEFEALDLFGPLGAIVPRSDYYTLALVSLHNLDSPHGVETSMKNGIGVIPTLSLAEALREDQQFDTLFIPGGFGMMPLVWDPILLQRIGQLVDRAPNVFSVCTGSILLAATGRLDGRKATTNKRLYDELTPKHPGVQWQKRARWVQDGKFLTSSGVTAGIDAGFAFLASTYVAPEDRQAHPEAQKASLQGDETPIPGFNKEKALRHAHFIAFGLEYRWHSDPADDPFVDLPEQTAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF92</accession>
    <name>B0YF92_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lignostilbene dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_101980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF92"/>
    <dbReference type="SMR" id="B0YF92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101980"/>
    <dbReference type="HOGENOM" id="CLU_016472_6_2_1"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="PhylomeDB" id="B0YF92"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="498" mass="57007" checksum="FD1B0C48AEAD9C37" modified="2008-04-08" version="1">MSEMRTHFPDRPQFSGFMKPCRVEGDISQLEVYGEIPKEIDGVFYRVMPDPQLPPFIENDPWFNGDGNVTAFRIQDGRASFRQRYVRTEKFMRERKAQRALLGKYRNKFTDAVEFRVRSTANTNVVFFNGQLLALKEDSPPYAMDPITLETKGLYDFEGQLPALTFTAHPKFDPVTGEMVCFGYEARGDGTPDVCYYRVSPTGQFKEVVWLVAPVVAMIHDFAVTDNWVVFPIIPQVCDIERMKQGGEHWQWSPETPLYLGVIPRRGAKGEDVKWFQYKNSFPGHTANAYEDKEGHLVIDLGLSEKNVFFWWPDAQGNAPEPSSIHSQLVRFTLNPHAEDLALPEPKILHQGNSEFYRIDDRFATHSYRHCYFDLMDPQLGTDFERIRPNLGGGYPLYNSLAHFDNATGQTEVYFPGNTHLVQEPVFIPRKDSTTEGDGWVLALVNNYATMASELHLLDTRDFTHAQAKILLPIRLRHGLHGSWVDGRDIGSQTEQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMJ4</accession>
    <name>B0XMJ4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_002940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002940"/>
    <dbReference type="HOGENOM" id="CLU_062870_0_0_1"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="PhylomeDB" id="B0XMJ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758179" description="GPI anchored protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27720" checksum="0AE4E9D76B960EBC" modified="2008-04-08" version="1">MKNFNPLVLLSLIPLVVANVEKTIFVAPQPSHIPSTDSTLDDLGLERLSPSYPTLRTFINASFPTPDSPGTDSWFFLENLTPGQRYEVRICYLATQPTSFTLDTFTLSSTMEDPSLLSSISLYSSARLAALDSSTSSSNPLVRNGKHHPPPSSRDPAPTSDSVLFLRIRAAADYFSLDRALMEHVPPVLVDVILDPFLWNVFPRSLVPTAGYLCVVGMVAVLLARWVMGAFGAMVEREVGESTTVDGDEKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN49</accession>
    <name>B0XN49_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_014580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN49"/>
    <dbReference type="SMR" id="B0XN49"/>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_1"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="PhylomeDB" id="B0XN49"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="72"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="231" mass="25729" checksum="8919AE95AB328A0E" modified="2008-04-08" version="1">MSDHGEVEVENPSGAFQALPKDALAEMGTIKLFNKWSYEDVEIRDISLTIGLTDANLLTRIYKYSDYIQIRNPVYIPHTAGRYAAKRFRKAQCPIIERLTNSLMMNGRNNGKKLMAVRIVAHAFEIIHIMTDQNPLQVAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQAIALLTIGAREASFRNIKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN62</accession>
    <name>B0XN62_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_014710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014710"/>
    <dbReference type="HOGENOM" id="CLU_097253_0_0_1"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="237" mass="26826" checksum="53D123528D7A10D6" modified="2008-04-08" version="1">MSSSRYQELWVSQEPVQPATRETDTVRSAWQLPAAMASTLSLLGYMMIPLALEKPENNPQINKTVLTIAAMVLIGVAYALSFVIVCAQIDQRAYLLHSVFLYVWPREAPCLTSSLFGLFNLVFSILCRNILPMNNLSTIVVSLCCAFVFLYALGALWIYGRTFADRTRIQYGSASPTLLTEEEMQRQQLLRLLQQNGKKKRSSAKAVQKTFKVDVPEVVSPGKGWDRYMPPREEYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN67</accession>
    <name>B0XN67_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_014760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN67"/>
    <dbReference type="SMR" id="B0XN67"/>
    <dbReference type="HOGENOM" id="CLU_030612_1_2_1"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="PhylomeDB" id="B0XN67"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="370" mass="41723" checksum="2E481FC67922687E" modified="2008-04-08" version="1">MNTTHRRRQAFYALPSSHWQMLAEPPFSLLDNFNRVDDAIDVNADIADSILAAGLASFGLPADPDPNDPRQNWHGTATSSDVNKAHSTIRQFYRDWSAEGRAEREICYEPVLRDLRDEFDTRHSDRNEIRVLVPGAGLGRLVFEICQAGFAAEGNEISYHQLLASSWVLNHTRGPQQHALYPFALHFSNLLSREQQLQKIMIPDKHPATVMMEAQAEDSSAFGTMSMSAADFVVLYNNPSNKEAFDAVATVFFIDTAPNLIRYIETIRHCLKPNGLWINLGPLLWHFEDGSNKGHGSGSDHSQGIGEPGNVELTEEEVFCLVERMGFSIEKRLSAENRPLCGYIQDPESMLQNLYRPSHWVARKKTEIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPN3</accession>
    <name>B0XPN3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-quinone oxidoreductase, 23 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_006990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006990"/>
    <dbReference type="HOGENOM" id="CLU_067218_0_1_1"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="PhylomeDB" id="B0XPN3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="228" mass="25752" checksum="498C32B66D4F79A8" modified="2008-04-08" version="1">MASSTSVARLVAYRRPTPYLWASSLRLSPLGSIATFSSSVSRAATPAGPPQPGFRLPAPRKWDQDPESSLDKASKYFLMAELFRGMYVVLEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPTGEERCIACKLCEAICPAQAITIEAEEREDGSRRTTRYDIDMTKCIYCGYCQESCPVDAIVETSNAEYATETREELLYNKEKLLANGDKWEPEIAAAARADAPYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ42</accession>
    <name>ERB1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome biogenesis protein erb1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">erb1</name>
        <name type="ORF">AFUB_008620</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NOP7 complex, composed of erb1, nop7 and ytm1. The complex is held together by erb1, which interacts with nop7 via its N-terminal domain and with ytm1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ42"/>
    <dbReference type="SMR" id="B0XQ42"/>
    <dbReference type="EnsemblFungi" id="EDP56156">
        <property type="protein sequence ID" value="EDP56156"/>
        <property type="gene ID" value="AFUB_008620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008620"/>
    <dbReference type="HOGENOM" id="CLU_011390_0_1_1"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ42"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000370417" description="Ribosome biogenesis protein erb1">
        <location>
            <begin position="1"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="619"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="660"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="709"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="766"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="796" mass="88988" checksum="BC75A6A0BD5F0E11" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQF8</accession>
    <name>B0XQF8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonribosomal peptide synthase Pes1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_009800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_6_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B0XQF8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000024">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000026">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000017">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000031">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000037">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000009">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000010">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000051">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000100">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="803"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3392"/>
            <end position="3468"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="4487"/>
            <end position="4563"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="5552"/>
            <end position="5628"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="6139"/>
            <end position="6220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2364"/>
            <end position="2386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="5515"/>
            <end position="5550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="5628"/>
            <end position="5658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2367"/>
            <end position="2376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2377"/>
            <end position="2386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="5642"/>
            <end position="5657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="6269" mass="697401" checksum="F85BAF61993CA50F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQN2</accession>
    <name>B0XQN2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_010560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010560"/>
    <dbReference type="HOGENOM" id="CLU_066767_2_0_1"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="PhylomeDB" id="B0XQN2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="200" mass="22453" checksum="D814EC577B1CF972" modified="2008-04-08" version="1">MSDSTVGQTKQFGKGQRTVPAQKAQKWYPVDDEPQPKKVRKAIRPTKLRESLQPGTILILLAGRFRGKRVILLKHLDQGVLLVTGPFKINGVPLRRVNARYVIATSKRVDISNVDQSVLEKVSASDYFTKEKKAEKKTEEAFFKQGEKPEKKKVASARASDQKAVDQSILASIKKEAFLGSYLASSFSLRNGDKPHEMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR26</accession>
    <name>B0XR26_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TMEM1 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_012010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012010"/>
    <dbReference type="HOGENOM" id="CLU_001428_1_1_1"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="PhylomeDB" id="B0XR26"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24965">
        <property type="entry name" value="TRS130_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="8">
        <location>
            <begin position="639"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="927"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1252"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1443" mass="160173" checksum="34C4355986993B58" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRB7</accession>
    <name>B0XRB7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_012790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRB7"/>
    <dbReference type="HOGENOM" id="CLU_020273_2_4_1"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="PhylomeDB" id="B0XRB7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="225"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="438" mass="47249" checksum="561B3B56494EC4C2" modified="2008-04-08" version="1">MSNLPSHASPSFGAQTPTTPQPVDELSLKSNITSAPALHSRLDELRDETSSQISSIDTDRGDMTPAVPASLLSPSFTPPATPGGSINTAELLQQTQLAGARQGSTHTKPPRLLSRLPNVECIVRARIPTTTGAEMFLHLYHNDLDNKEHLAIVFGNTIRSRSLDKIRPGETEMDRMIRGAYVGKLRPGRVSSWYDEEKAEEAASPEAGGAVSSPHTLPRSSLKEAPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSLPMETLAEAASPPDGAVPSNAAGGVIVYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAILVDLGLGIDSNPHGIRLLTNNPDKIRAVEGPNREVVVKERVPMVPLAWRSGGKMGIKSSEVEGYLRTKVCRQSISCKLAYFLIILEQCLTLSSQISKMGHLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS67</accession>
    <name>B0XS67_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_026120</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026120"/>
    <dbReference type="HOGENOM" id="CLU_049331_2_0_1"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="PhylomeDB" id="B0XS67"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.820:FF:000004">
        <property type="entry name" value="Putative RNA polymerase II subunit B1 CTD phosphatase rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="109"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="326" mass="35716" checksum="5B31BD19E4F9F956" modified="2008-04-08" version="1">MPANKPILKTSLPTAHAASSTAALQKPNNARRAPPKSKALEQQKGQPTNRPNVDPRHLAIAMHHAHQIQAQKDTEALILDRILELVNFPSSLTVDPAAPSAEDARAFKAALVPFQPADYDNLILERNIEGLCGYGLCPHEHRKEDTKGKFRITWGAKGSGPGGRGREMNIVPKEKLEMWCSDECAERAMYIRVQLAEEPAWERRDGRHAKELVLLEEDRARARKGKSKMSSSATLKEVTGQLEGLNMEGTEGPNDLANAISGISLDAARFRELAMERGDANPALQAGRVDIAIRENEGLSQHVTPPQMRPGDDKGGSIEGYVPKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS70</accession>
    <name>B0XS70_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_026150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS70"/>
    <dbReference type="HOGENOM" id="CLU_006320_4_4_1"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="PhylomeDB" id="B0XS70"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="606"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="718" mass="79540" checksum="BE2B254473BEA7F1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSG8</accession>
    <name>B0XSG8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_027140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027140"/>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="PhylomeDB" id="B0XSG8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP54654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="358" mass="41549" checksum="FB49C431F7B88880" modified="2008-04-08" version="1">MPSTYKRDKPWDTDDIDKWKIEEFKPEDNVAGSFAEESSFATLFPKYREQYLKEAWPVVTRALEKHGIACTLDLVEGSMTVKTTRKTFDPAAILKARDLIKLLSRSVPVQQALKILEDGVACDIIKIRNQVRNKERFVKRRQRLLGPSGSTLKALELLTSTYILVQGNTVAAMGPYKGLKEVRRVVNDCMANIHPIYHIKELMIKRELAKDPTLANESWDRFLPNFKKRTLSKRRVPYKVTDKSKKVYTPFPPAPEKSKVDLQIESGEYFLSKEAKERAQKEEVMERQRQKREEKMKERAKSFIPPEELEAEEKKKEKKEKKKRKREAEAEPEDSSEKKEKKKKKKSKSKDASSDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSI1</accession>
    <name>B0XSI1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_027270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027270"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="PhylomeDB" id="B0XSI1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF92">
        <property type="entry name" value="LOW AFFINITY GLUCOSE TRANSPORTER MSTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="55"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="560" mass="62118" checksum="ED7443D062C751F2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSP2</accession>
    <name>B0XSP2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_027880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSP2"/>
    <dbReference type="SMR" id="B0XSP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027880"/>
    <dbReference type="HOGENOM" id="CLU_141397_0_1_1"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="PhylomeDB" id="B0XSP2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="113" mass="12089" checksum="A88257F585C86AC4" modified="2008-04-08" version="1">MAIWGSSSSNTASSGEADIKTHLMNQVRQEAAVTNARNLIGKVNEHCFEACIPNPGTSLSSAEHTCLSQCMEKYISFWNAVSRGYIARLANERKAYGGGALDASFVQSGESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSV5</accession>
    <name>B0XSV5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_017750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017750"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="B0XSV5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760446" evidence="4">
        <location>
            <begin position="27"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="365" mass="41259" checksum="1A3673D816DF5E57" modified="2008-04-08" version="1">MALILLYGYVMRRGVLWLFLFEMMTSTNLDLASEQKYVAVKVLASNHQEQALSGELGIYKHLSRLKSSHIGSAYIRGLDRRFSESLFKETLLCILQALDFLHREGNVVHTGMSPATADRREYLLEMTDGVTDIKATNIMLRIDDESILEDFEKAEQQSPSPEKVVGKNRTIYTSRRLRLPHDDLWGQPVLCDLGQARIGRAHTGLIQPEIYRAPEVLFDMGWGHSADIWNLGVMAWDIFEGRPLFSALDEDQEYSPSHHVADGDGGCSWAATVVLHPAKPGNSQCIFRERSFSLSSLADQANDFIGEWLGEGGVTIPNTSLERLEEKLNGNGQQSFLQFTRSMLQWTPETRKTAKELLKDPWRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT11</accession>
    <name>B0XT11_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicular-fusion protein sec17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_028490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028490"/>
    <dbReference type="HOGENOM" id="CLU_046329_1_0_1"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="PhylomeDB" id="B0XT11"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="32841" checksum="844215D4D2F1134A" modified="2008-04-08" version="1">MAQDPRVLLQKADKALQGASSGLSFFGGRTEKYENAADLYTQAANAFRVQKLNKEAGLAFEKAAAIQKQNLNEPDDAANTLQEAFKVYRKSDPEDAARVLSAAIQHYVLKGNLRRAATQQQHLAEVYEVELGDMKKALEAYEKAAEWFDGDNAEALANKHYLKVADLAALEGDYYKAIENYERIGRSSITNNLMKWSVKDYFLKAGICHLASKDIVAANRALESYRDTDHTFASTREHQLLVDLVQAIEAGDQEAFSDKLFQYDQLSKLDKWKTTLLLRIKSNIEEAEEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT67</accession>
    <name>B0XT67_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease III homolog</fullName>
            <ecNumber evidence="15">3.2.2.-</ecNumber>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="15">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NTH1</name>
        <name evidence="18" type="ORF">AFUB_018200</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018200"/>
    <dbReference type="HOGENOM" id="CLU_012862_4_1_1"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="PhylomeDB" id="B0XT67"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000027">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="17">
        <location>
            <begin position="193"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
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            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP53776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="432" mass="47714" checksum="69C7CFA83B6B3D13" modified="2008-04-08" version="1">MRTSRTSKETASFLQALSPPTRRQTRSSSRTNVLQRFAFNASANGQAETAPTTTGAQFQQSDGDDTSSLSSVDTVDIEDILEPPLKKRKSSPGSPSTKRTTRAPGRTITKREAVKVEPAKPKSRRVPARKIKGENGSIKIEPPSNWETIYSMVKKMRENNPTAPVDTMGCAELYWRSSSPRDKRFQTLIALMLSSQTKDTVTAVAMQRLHTELGNGRALAEDPIVKKEEQEDIDLKSSQPLKDSTLNLENILAVSPEKLNELIRTVGFHNNKTKYIKAAAEILRDQYNSDIPSTAEELMKLPGVGPKMAYLCMSAAWGKDEGIGVDVHVHRITNLWGWHKTKTPEETRMALESWLPRDKWHEINKLLVGLGQTVCLPVGRRCGECDLAGTKLCKSEVRGLLSKKNAGVKPKDEVLKDDGLASGGAKVKVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT90</accession>
    <name>B0XT90_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD+ kinase Utr1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_018430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018430"/>
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    <dbReference type="OrthoDB" id="24581at2759"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="601"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="657" mass="71577" checksum="5312D753DC2D6C6C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTA2</accession>
    <name>B0XTA2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nudix/MutT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_028710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTA2"/>
    <dbReference type="HOGENOM" id="CLU_037162_5_3_1"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="PhylomeDB" id="B0XTA2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052846">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052847">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071545">
        <property type="term" value="P:inositol phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000046">
        <property type="entry name" value="Nudix/MutT family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP54811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="161" mass="17746" checksum="B2845DA77D48EBA8" modified="2008-04-08" version="1">MSSSTTSTPDKKLIYPESLGYGSKGERLVAGVVPLSHDKTRVLMIQSVGSGGWVLPKGGWETDEALAQQAACREAWEEAGVICTVHKDLGLIPDMRPSSVLTSSAPKASYQFFEVTVDREEDQWPEMHKRKRQWVTYAQAAAALASRPELLEALNRSSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU61</accession>
    <name>B0XU61_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_030450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU61"/>
    <dbReference type="HOGENOM" id="CLU_017005_0_0_1"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="PhylomeDB" id="B0XU61"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019826">
        <property type="term" value="F:oxygen sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.20:FF:000001">
        <property type="entry name" value="Putative oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="95"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="572" mass="64321" checksum="EEFAA587BAA21F46" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUM5</accession>
    <name>B0XUM5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium/calmodulin-dependent protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_020560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative calcium/calmodulin-dependent protein kinase"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aur-like"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="113"/>
            <end position="418"/>
        </location>
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        <location>
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            <end position="87"/>
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        <location>
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            <end position="454"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="540"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="601"/>
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    </feature>
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        <location>
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            <end position="79"/>
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        <location>
            <begin position="430"/>
            <end position="454"/>
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            <begin position="518"/>
            <end position="528"/>
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        <location>
            <begin position="581"/>
            <end position="597"/>
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        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
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        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="7">
        <location>
            <begin position="258"/>
            <end position="259"/>
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            <position position="305"/>
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        <ligand>
            <name>ATP</name>
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            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP54010.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="645" mass="72127" checksum="FC0C79CD517B118D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUX0</accession>
    <name>B0XUX0_ASPFC</name>
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        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
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        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
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        <name evidence="12" type="ORF">AFUB_031720</name>
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    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
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        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="rRNA biogenesis protein RRP5, putative"/>
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        <property type="entry name" value="rRNA biogenesis protein RRP5, putative"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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        <property type="match status" value="12"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
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    <dbReference type="PROSITE" id="PS50126">
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    </dbReference>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="157"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="276"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="465"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="557"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="651"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="835"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="944"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1320"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="906"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1394"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1399"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1426"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1487"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1512"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1822" mass="200070" checksum="2010CC7E646FE5AC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV93</accession>
    <name>B0XV93_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_032310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032310"/>
    <dbReference type="HOGENOM" id="CLU_018204_4_1_1"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="PhylomeDB" id="B0XV93"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF17">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G16630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="157"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="262"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="437" mass="48315" checksum="DDE947ED4C91527D" modified="2008-04-08" version="1">MTRKDPPPTAPYSEPLLPQLDIKNPYYTDLHHELRAYVRNYVETSIVPYAQDWETAGQVPEEVRRRHCDLGFGIVHPLTSEEDAAGISLPGNVPREKWDTWCNLIVTDELTRVGYVGVIWGLGGGNSIGCPPIARFGTPEQRRRWLPKVARGDIRFCLGITEPDAGSDVANIQTTARLDGDHYVVNGAKKWITNGIWADYCTAAVRTGGPGRNGISLLVIPLTAPGVTRRRMHNSGVNASGSTFLQFEDVRVPADNLIGKENKGFPIIMSNFNPERLTLACAALRLARVCAEDAFHYAVQRETFGAPLIQRQAIQSKIFRFGLMIEPAYAFMEQLVNIIELTKDRPADDVKIGGMTALLKVMSTRALEKSVREAQQILGGAGYNKSGRGARIEQISRDVRVHVVGGGSEEIMMGLALQEETKALKTRRQALEKQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVT0</accession>
    <name>B0XVT0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_022650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022650"/>
    <dbReference type="HOGENOM" id="CLU_074872_0_0_1"/>
    <dbReference type="OrthoDB" id="3599883at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="35876" checksum="6ADAA354CA9C898F" modified="2008-04-08" version="1">MTQSNSHLHHGRTPSSNGSKVRTSRPTLHRKGTYSVNHPISKLGSGQVRRPEPESDRQPDMAASFLNFCAMCERQITVPDNSLLYCSESCRRKDSHKPLSASFPSSGSIPYLRSPPTSPLVSSRMIVAPMTPTKAPLKSTPTTGISTDVHDSKVDQDPSEWKPVIPAAYGSTGSLASTEAWHYLSQFHGSEPLFPRRRDGAGHRSSASLSTLMSATAPVPSLTHTPSTTASSFSSTASDYIGYIPESSHRPLPPRHNPYFSNGAGVTKSVELVVPHVETPSMHANAVDMSDSGSIFPASSSLWNESLAGKTPTETVTKAPSALDLPIMLKQETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVX8</accession>
    <name>B0XVX8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein HRP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_023170</name>
    </gene>
    <organism evidence="6 7">
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
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                <person name="Anderson M.J."/>
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                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Bussey H."/>
                <person name="Bowyer P."/>
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                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
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                <person name="Orvis J."/>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Bussey H."/>
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                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
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                <person name="Orvis J."/>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024120"/>
    <dbReference type="HOGENOM" id="CLU_014393_4_0_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="PhylomeDB" id="B0XWA4"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="249"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="580" mass="64066" checksum="5D60F07FFAD9D9BD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWN2</accession>
    <name>B0XWN2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS alpha-glucoside transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_046700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046700"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B0XWN2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="550" mass="61278" checksum="ADB58C0BEDF12078" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX80</accession>
    <name>B0XX80_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_037130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX80"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037130"/>
    <dbReference type="HOGENOM" id="CLU_029371_0_0_1"/>
    <dbReference type="OrthoDB" id="5296720at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="361" mass="40664" checksum="6FCDBF9B5E88D6C0" modified="2008-04-08" version="1">MSAATSPFESLPNELIDQILSNLATDPPSWSRFDQAPCVRIVKSATRDLKNLSRTSSRLREVTRPRLFAHVCFDISEGESFLQFIQKWNLCRNVTSILARGNTGSDPQDDPSWWRRILHYLDPLRITLLAPPSFIGATLGTQIMDGHNWAFQISLQELQLERTQRQAAPPPVSHVEDCSGLLAAREWSSLQFNESSSLKAYNHYEYFLFQVPSVFNRWGSLSRTHPESVSLSLSLNRLTAFHYTAVFPFYNHVKLVLDSAKLMTSLRSLSVRLAPCLNDKATELEQRGSMDPSDPWMELATGYTLVAHAVRDLGNKSLVHFCACDYESDALRPELSAILTDVLGDSEWAHDGHGNWVKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXD7</accession>
    <name>B0XXD7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_047970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047970"/>
    <dbReference type="HOGENOM" id="CLU_021916_1_0_1"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="PhylomeDB" id="B0XXD7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF48">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="400" mass="44949" checksum="084E19915D30F0A8" modified="2008-04-08" version="1">MEDRQRHCWECLRRSLVCDFIRPQCKRCSTSGIVCPGYEDKAPFRLKWLPPGRSKSLAVTFYRYRGLVIRSLRNDINQGHKRASDVVLAGIITLLLVDVSLKCSMRNHPPILNHILLRKAQQGASPHWRYHMEGLQKLILLRGGIRSLARSARLAPLLHCFVCIAVIGDTVSPTSHLATSRLRLEESDFILENLGNGVFDFQMCPKPLFAEIIRINHLRVQAWKQSPTRPGPLAQEAYGVLNRINTFSSERWADSKPSSKEDWRIVGESYQAAVSLYCILSLQSLSVLPLNPSLRASCASCGRLLQDLLNEALSSPRIKRSVLWPLVVLGVLAVNGGAGMRAFVREHLPEMSRHIGSYVPLMAKALLEKFWASGETSWDACFDKPYTVVTQIAVDLSQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXR2</accession>
    <name>B0XXR2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase GstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_038300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038300"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="PhylomeDB" id="B0XXR2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000052">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="97"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="254" mass="29085" checksum="F0033ADDBBE995C9" modified="2008-04-08" version="1">MANRPDITLYTTQTPNGIKISIALEELGLPYKVEKIDISKNTQKEPWFLEINPNGRIPALTDTFTDGQKIRLFESGSILTYLAEQYDKDYKISYPRGTREYYETISWLYFQNAGVGPMQGQANHFVRYASEHIQYGVDRYVNETRRLYGVLDKHLSTSKSGYLVGDHVTIADISHWGWVAAAGWAGVNIDEFPHLKAWEERMAARPGVEKGRHVPAPHTIKDLLKDKERMEQEAAKTRQWVQQGMKSDANKAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXU7</accession>
    <name>B0XXU7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-(Acyl-carrier-protein) reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_038620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038620"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="PhylomeDB" id="B0XXU7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="321" mass="33425" checksum="1C5B631B80E86D80" modified="2008-04-08" version="1">MAARLAQVNAHLNYPAGLLAGKVAIITGSGQGIGAEAARLFANEGAKVIVADIDAVTNTTGPTEKATAVANAINAAGAGRALAVVGDILDDAYIKDLVSKAAEFGNGKIHILVNNAGFTWDGVIHKITDKQWDTMLAVHNTAPFKLIRAAAPYFRVKDGEDRVIINISSTSGIHGNAYVYISPSAVDISCADGCWVTRGQANYALAKAGLVGLTKTITKEWGPAYGVRANTIAFGFVKTRLTAAKEEGAFITTPDGTKVALGIPGKQLAGRKGDEKQAYPDIPLGRPASPEEAARAILGVCSPYFSYVSGETIRVTGGRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY29</accession>
    <name>B0XY29_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_039440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY29"/>
    <dbReference type="HOGENOM" id="CLU_496924_0_0_1"/>
    <dbReference type="OrthoDB" id="4506111at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="548" mass="61101" checksum="707E99F327B65BC4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY83</accession>
    <name>B0XY83_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_040000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040000"/>
    <dbReference type="HOGENOM" id="CLU_007091_2_0_1"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="PhylomeDB" id="B0XY83"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP52829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="777" mass="88069" checksum="351D9ED721BFA044" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYN4</accession>
    <name>B0XYN4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ER-Golgi SNARE complex subunit (Sed5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_041520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041520"/>
    <dbReference type="HOGENOM" id="CLU_044998_0_1_1"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="PhylomeDB" id="B0XYN4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090083">
        <property type="term" value="P:regulation of inclusion body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="254"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="346" mass="38266" checksum="535B139B61C1FA8F" modified="2008-04-08" version="1">MVGPSIQDRTGEFQAILGQAQKRLATSKVGSQRQALLSDSQRRQAHAGTDGQGPSKRRSEFARRAAEIGRGITATTAKLQRLAELAKRKTLFDDRPVEISELTYVIKQDLASLNQQIASLQALTLSQHPKTNRSKADQEGEHNDNVVVMLQGKLADVGANFKEVLEVRTKNIQASRSRTENFVSSVSSKSQVLDPQRSDSPLYIPSGRRTPQPGFQGGSSDLLTLDPSNPSPLGRPSFQTDQQLLVMEEAQTNNTYIQARGEAIDAIERTISELGGIFGQLAQMVSEQSEMIQRIDANTEDVVDNVEGAQRELMKYWNRVSGNRWLIAKMFGVLMIFFLLWVLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZQ2</accession>
    <name>B0XZQ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_044840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZQ2"/>
    <dbReference type="SMR" id="B0XZQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044840"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="PhylomeDB" id="B0XZQ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF152">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03410)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="270" mass="29345" checksum="8C276534BAFECAB2" modified="2008-04-08" version="1">MSTEAHPTVQGCLVSFPTPHILLLTLNRPEKRNCISLATSAEIQRLWTWFDTQPALYVAIITGTGESFCAGADLKEWNDLNARGITNEMTAPGLAGLPRRRGSKPIIAAVNGYCLGGGFEMVANCDIVVASENATFGLPEVQRGIAAVAGSLPRLVRVLGKQRAAEIALSGLSFSASQLERWGLVNRVVEHDQLLATAVEIATAISRNSPDSVRVTMEGLHYGWEMASVEEASSALVDQWYAKLMAGENFHEGVRAFVEKRKPQWRPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZR5</accession>
    <name>B0XZR5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044980"/>
    <dbReference type="HOGENOM" id="CLU_066901_1_1_1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="PhylomeDB" id="B0XZR5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760587" evidence="1">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="238" mass="26106" checksum="F99BBE91CF37E43F" modified="2008-04-08" version="1">MRFITVLQTIALLAASMTVKAWNQLDKENAAVLIIDYHVGLAQLDRDFNTNDFRNNMLAHAALGNLFDLSVVMTTSSDAGPNGLTIKEVVDLNPNVTIVHRQGEVNAWDNAEFRAAIQATGKKQLIVSGIVTEVYRHRLLGPLAHRRRIRGLANTEASGTFDDKLAADANHRMEKAGVTLMGTFGVVTDLMRDWRNTPGLDQVLPYLDKYQYACGLVARHHAGALENGTLAAVESTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZX0</accession>
    <name>B0XZX0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_034660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034660"/>
    <dbReference type="HOGENOM" id="CLU_030126_1_0_1"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="PhylomeDB" id="B0XZX0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760739" evidence="2">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="462" mass="51296" checksum="2239D66B3C3BF728" modified="2008-04-08" version="1">MLSLGLALLFSGTAALASRDTFYPPLNHTTFITNASYGTYGGIYTAPADSAGSPSADDVYNYCSMPHPRGETYSLPPPVANHSIKAKLVYLEYLQRHQRRTPYNILPGGEDQEYNCDSVDPHVYVAPASQHPSPVAVYGQTYSDPSNPYLATYANGTCQYPQLTLGGFLDGYQHGRDLRAVYGRRLGLIPPVPDQKRVWFRSSSSALTQGSAGAVLRGLWPEYHKPIPVHQQASAVDTVNRGFPCSARSALLSAIQSTAEWNEHLNVTQALRDELAAMFDAQDESAWTSNFDHFADNFQARLCNGYRLPCRVQDQTQCVTAAQANEVFRAGDWEYNYMWRRNANATRYIQVIEGLFIGEIVRKFEAVAEGASKLAYSHNFVHDGDISPILGALGITAMRWPGMGSNIAFEIWKTSTSEYFARVLYSGHAIETIHGRLDWIPLSRLLDILRPFIPEDIKSMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0B1</accession>
    <name>B0Y0B1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_035380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0B1"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0B1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF140">
        <property type="entry name" value="ATPASE, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP52375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="350" mass="39091" checksum="5D6251617C50BEFB" modified="2008-04-08" version="1">MHVSMLCKNFRLIPSQALNILFALCGITGSLYGMGRKLEHVEQFSTALFWWWLGQTSYVVTCVVAKISIAVALLRLTVTKMHTMLLWTVIGVTIVVGLVFWFVLTLQCKPVSYFWNRLSPGAKGTCLDVDTIIGIAYLYSVTATLCDFVLGLLPISLVWKLQMTRKTKIALAVILSLGCIASAAVIVRIPYLHYYKDDEFLCKSPRRMLSSRANINRLHTDATTDISIWSNVEASLGIMAGSLVTLRPLFRWFRGTSYGRSKTTKRTFGSMPLSSMNGNGNGTHQSKLDRDATQYWRPDVYPHESRAVVTTIQTSPRGSKSSSQEDLNPKQEPLHGVNVHKSFLVSSDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0Q4</accession>
    <name>B0Y0Q4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_058160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0Q4"/>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0Q4"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="201"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="747" mass="85711" checksum="1807E05BF49F4CA2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0Q6</accession>
    <name>B0Y0Q6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_058180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0Q6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058180"/>
    <dbReference type="HOGENOM" id="CLU_070101_1_0_1"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0Q6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="196" mass="22218" checksum="7C61BA14B4E1B3BC" modified="2008-04-08" version="1">MFLRSVSRAAARSSVMPTTATRSYRTVPSPIACLNARPQPQQKSIASQQTRASSEHAISNPTLAGIEKRWEAMPPQEQAELWMQLRDRMKVDWHQMTLQEKKAAYWIAFGPHGPRAVPPKGESMRIFFKVAQLTLVSLALFYVIHLFAKPKPKTMTKEWQEATNEYAKREKINPLYGVSSEGYEGKGFIQSPPAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0X0</accession>
    <name>B0Y0X0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Scramblase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_058820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0X0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058820"/>
    <dbReference type="HOGENOM" id="CLU_038823_3_0_1"/>
    <dbReference type="OrthoDB" id="189619at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052169">
        <property type="entry name" value="CW_Biosynth-Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33393">
        <property type="entry name" value="POLYGLUTAMINE SYNTHESIS ACCESSORY PROTEIN RV0574C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33393:SF11">
        <property type="entry name" value="POLYGLUTAMINE SYNTHESIS ACCESSORY PROTEIN RV0574C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Capsule synthesis protein CapA" evidence="3">
        <location>
            <begin position="94"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="474" mass="53995" checksum="27CABE0E38072A06" modified="2008-04-08" version="1">MILARIKLQQKNDQPSEAQSSHNALNHAITNSDSKDTTSVCSSNGNSRCHDDPTTFYKHNGHQHTHMHSGSNSLSTVPAQGESIDMPSALRTFTLNFVGDVMLGRLVDQLWPQHVDNAHERRVVSYFIERYPYLSKYTHRDPWGSALPLFHNSDLNLINLETSATTTNDPWPSKAFNYRMHPANAAALREARIDYATLANNHTLDFGTDGLVETVWTMKESKIAFAGAGETTDESRRPAVLRLPRCAEAHAQDSHEQSSKSYSVHVYAASDHPRDWAVVPTFHLIDYSARTREHLRTLLTSPPASTDTPEKPALKIFSVHWGPNYTWQPAEKIRSLAHFLIDECGVDIVHGHSSHHVQGVERYRRKLIIYGCGDFVDDYALNEEYRNDLGAVWRVCVREEQDEEEADPESCRLVLDRLEIFPTRCDRFQVTLLDPDDDDHLWVKRKITQLSEDMGTKVRRDLGREHQVVVDLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1D3</accession>
    <name>B0Y1D3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XPG I-region protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_059880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1D3"/>
    <dbReference type="HOGENOM" id="CLU_378548_0_0_1"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1D3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="333"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="470"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="82713" checksum="225624761DEB1875" modified="2008-04-08" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1M2</accession>
    <name>B0Y1M2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_049800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049800"/>
    <dbReference type="HOGENOM" id="CLU_497887_0_0_1"/>
    <dbReference type="OrthoDB" id="2958197at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760631" evidence="2">
        <location>
            <begin position="21"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="597" mass="65800" checksum="8B8C28F692FDE36C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1P4</accession>
    <name>B0Y1P4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_050020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050020"/>
    <dbReference type="HOGENOM" id="CLU_009942_5_0_1"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1P4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF19">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G01480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="533" mass="58240" checksum="7A1A6115C2F3BACB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1P7</accession>
    <name>B0Y1P7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_050050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050050"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1P7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF21">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="66"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="566" mass="60914" checksum="40D03EFB246D5B7A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1Q8</accession>
    <name>B0Y1Q8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_060470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1Q8"/>
    <dbReference type="HOGENOM" id="CLU_041575_4_0_1"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1Q8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="252" mass="28646" checksum="2148682364777DB2" modified="2008-04-08" version="1">MTTEAQHTTDFLTRESVTGPRPVWDTPAKATTYSFPSMEPLRVVEYPRNHLLMPLRKDILHRAVVYEGDMTRQGTASTKWRDDVHGSGKKLYAQKGTGRARVGDKKSPIRRGGGVAFGPHPRDFATSLPRKIYDQAWRIALSYRYKRGQLIIIDNEISIPEGATPHLIKEIFKVNCWGREFGRSTLITDQLNEGLFETVREVGEHAKILNRKDVDVKDLLETGRLVIEKQALDRILSQHSRDLVNKPATAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y231</accession>
    <name>B0Y231_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_061070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y231"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061070"/>
    <dbReference type="HOGENOM" id="CLU_024328_0_0_1"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="PhylomeDB" id="B0Y231"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000007">
        <property type="entry name" value="YjeF N-terminal domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="450"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="702" mass="76080" checksum="84B3D450E989400E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y232</accession>
    <name>B0Y232_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="15">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PIF1</name>
        <name evidence="18" type="ORF">AFUB_061080</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y232"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061080"/>
    <dbReference type="HOGENOM" id="CLU_001613_0_1_1"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="PhylomeDB" id="B0Y232"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="297"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="15">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="305"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP52074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="788" mass="87865" checksum="F6CEAA062708AE01" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y252</accession>
    <name>B0Y252_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_061280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y252"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061280"/>
    <dbReference type="HOGENOM" id="CLU_022946_0_0_1"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="PhylomeDB" id="B0Y252"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="KsdD_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009472">
        <property type="entry name" value="PRK12834.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="3-KETOSTEROID-DELTA-1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260:SF1">
        <property type="entry name" value="KSDD-LIKE STEROID DEHYDROGENASE RV0785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="405" mass="44330" checksum="552B919F78EF707C" modified="2008-04-08" version="1">MATNDQPVVIVGAGLAGLVAAYELSNRNIRSIIVDQESEANLGGQAFWSLGGIFCVNSSNQRRLGIRDSRELAMEDWFSSAAFDRETDHWPRKWAEAFVNFATDHMESYLGALGVRFVSVGWAERGSGQAGGHGNSVPRFHLTWGTGPAIVEAFAGPVKEAAKKGLVEFRFRHQVDEIIVDGETGAAVGVRGQVLEPTDVERGVASSRKSVGYFELRGAAVLVASGGIGGNLDLVKKYWPVDRLGPKVPQSFVLGVPAHVDGRMIDISRKAGASVVNSDRMWHYTEGLTNWNPIWPKHGIRVIPGPSSLWLDATGKRLPPFLYPGCDTLATLRHICSTGYDYTWFVLNKSIIAREFALSGSEQNPDITGKSILLLLQRIFGSNGTGPVQVFMKKWRRFHRGDVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y284</accession>
    <name>B0Y284_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp90 binding co-chaperone (Sba1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_061630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y284"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061630"/>
    <dbReference type="HOGENOM" id="CLU_078883_0_0_1"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="PhylomeDB" id="B0Y284"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000043">
        <property type="entry name" value="Hsp90 binding co-chaperone (Sba1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="201" mass="22212" checksum="7CC52BDC947986B7" modified="2008-04-08" version="1">MSQLTPEVTWAQRSSSSDPERNYLYVNIKTPDVAKSAADLKITPTNVSFTGETNKGVKYHVSLDLYAEIDPENSKVNHTDREVELVLRKKELKEEYWPRLVKDTQKLHFLKTDFDKWVDEDEQDEAGDDDYANNFGGFEGLDQGGLGNIDFSKLGANLGGGAEGEGAEGDESDEEMPELEGDSKAEGAEGEAKSSKIQEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y294</accession>
    <name>B0Y294_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PAP2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_061730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y294"/>
    <dbReference type="HOGENOM" id="CLU_019266_0_1_1"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="PhylomeDB" id="B0Y294"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="430" mass="47506" checksum="3C9F561E5BB380FB" modified="2008-04-08" version="1">MSGSAALEYGFPSTHSTNAVSVAVYVLTLLNSPDSTVSSHINLIFQCMTYLYVSSIVLGRLYCGMHGFLDVIVGCLLGASITFVQNLFGPLLDDYVFSASGKQIALVVLVIIILVRIHPEPADDCPCFDDSVAFAGVIIGVQLGCWHFAKSSIAWSDPSPATIPFRYKDLGLVKTVLRFVLGVFLIFTWREVMKPLLLRTLPPIFRALEKLGLLLPRRFFTRASQYKTVPAHLKDHEVLPSFAEIPSILTNIRHPRRRAISIGPQSEADAYETLAYREKRRRESLSNNAHNYSVAEDGGDTGNVSMSGTQPSKLTRKQSKLDEYEHMMGTGISRHSPDAIAVMDREPSTEPFPAYDEGKEPDLTEVFSQVKKPRVRYDVEVVTKLVVYSGKSCRQGAAMIIFLTICPMLGIAWVTIEGAPIVFDKVGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2A4</accession>
    <name>B0Y2A4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_050760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2A4"/>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_1"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2A4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="113"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="571" mass="63124" checksum="0EE0C209C4E4542E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2P4</accession>
    <name>B0Y2P4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_051480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051480"/>
    <dbReference type="HOGENOM" id="CLU_2385737_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="94" mass="10347" checksum="98DB5CC0CCEE5C1B" modified="2008-04-08" version="1">MQCQGCDGSSSRLSKPHTFDAVIGPVGCAGLIDGRNCPTQGCGWLIERMHMTLSSLLPQGQSGRLQKCTERVKKIDNRKNDEKGDILKIKMRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y321</accession>
    <name>B0Y321_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_052660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y321"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052660"/>
    <dbReference type="HOGENOM" id="CLU_026017_0_0_1"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="PhylomeDB" id="B0Y321"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55108" checksum="67665AF3E0F18916" modified="2008-04-08" version="1">MPKRKAFLKEAKSKKAAQRAPETADEFLAAGVEQEEGGEKWRAGDAAKSFRFFMRAIAIYDEGLQKHPQAFDLAYNKARLQYEITQHPKLAAQLPTPLLDALQIALQSHREALNLEQDNADALFNTAQVLTSLAEAATDTKHPSDEQLSGAIKLLQEAIELFQRCLMLQELRYTEMQEQLKQMESGDMGPPEEEMKQAQDAMDIAGQPDPSEPQEQWAAVIEPVTKNTLVDTAVAQLDTLTTLSNLLTFNPGVGLAWVEEYSSDLLQRIPVYLEGSERQYEASLARARFVCALNELVYRSGRIEVETYHREITGAFGPDLDISTDPDGLCSKADALTSFNTALTDLPPSHDAEAFAKSLHMRWQSLSTALDALTKASKLPDANNLPKIHMARGDVEMHRWRLGLAPWEYAVAGQNASTLLGNAQTYYRGAAALARRDGAMEETRDGTCKEAIAAALGGQKDKLEQLKAAAPKELTAVAQDMVEDGLLTPVEMEALLSYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y346</accession>
    <name>B0Y346_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_052910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y346"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052910"/>
    <dbReference type="HOGENOM" id="CLU_1467844_0_0_1"/>
    <dbReference type="OrthoDB" id="449091at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="184" mass="19807" checksum="DFE364E31685A71C" modified="2008-04-08" version="1">MAATWPFPLWYQSALAVNGSVKWKTARALSHNFAPGKTRTELHAWARGSLNTGHWAPQSVAIFTSGLLEIVIDGKRHFGGDFYNYGTVPIIIDLSTGDHAVELRLVRDVRASGAIGEPTIVVSLAAEIRNEPLSADNESLLLPDMCLGKLGTPWASINLHNNIADRITILAISSIGVSANSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3F2</accession>
    <name>B0Y3F2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar protein sorting protein DigA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_053990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3F2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053990"/>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3F2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="619"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="856"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="811"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="961" mass="107865" checksum="99E4ED5C835151E9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3F9</accession>
    <name>B0Y3F9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome biogenesis GTPase Lsg1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_054060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3F9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054060"/>
    <dbReference type="HOGENOM" id="CLU_011072_2_0_1"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3F9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001558">
        <property type="entry name" value="Ribosome biogenesis GTPase Lsg1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="177"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="676" mass="75565" checksum="8E0FD682F7FC8B7D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3T4</accession>
    <name>B0Y3T4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF914 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_055340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055340"/>
    <dbReference type="HOGENOM" id="CLU_039639_4_1_1"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3T4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="435" mass="48593" checksum="17BF08FA23A1530D" modified="2008-04-08" version="1">MSDTKQPVGVQTSSAVPDAVTSPYFEPPKYNDPVTVNKNTGEDDSGSEAVADRIDTQKKGFWAYFTTKEFYITLILGQVLAITNTATSTFSTLLSQEGTSIPAFQSFFNYVLLNLIFTPYTIYRYGFKGWLRLMWRDGWKYIILAFCDVEGNYFIVLAYRYTTMLSAQLINFWAIAVVVFISFLFLRVRYHITQILGILICIGGMGVLIASDHITGSNGGDVSSGNQIKGDLFALLGASFYGLTNTGEEYFVSSRPVYEVLGQMAFFGMIINGVQAGIFDRHSFQIAVWNSRVGGYFTGYTLCLAFFYCMAPLLFRLSSAAFFNISLLTMNFWGVCIGIEVFHYKIHWMYPIAFVLIIVGQLIYFLGKRVLGEARKPWLGKNQERGFAGLFTAKAKIDSVRAKLASNNNHNVNAGGAHHDDRTAATIDERHSNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y408</accession>
    <name>B0Y408_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_056100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y408"/>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="PhylomeDB" id="B0Y408"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="156" mass="16166" checksum="AD3AE8BD598F4103" modified="2008-04-08" version="1">MAESELAPKFAPFFSFLRILPLRSMGAAYGTAKSGIGISGVGTFRPDLIMKSLIPVVMSGIIAVYGLVIAVLIAGDMAPPPTQNMSLGFMHLASGLSVGLAGVAAGYTIGIVGDAGVRAYMQQSRVYVGMILILIFGEVLGLYGLIVGLILNSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4H0</accession>
    <name>B0Y4H0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endosomal peripheral membrane protein (Mon2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_069060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069060"/>
    <dbReference type="HOGENOM" id="CLU_001169_1_0_1"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4H0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="174"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="958"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="720"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1688" mass="186565" checksum="3B66D019D4787279" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4M5</accession>
    <name>B0Y4M5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GATA transcription factor LreB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_069610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_024414_1_1_1"/>
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    <dbReference type="Proteomes" id="UP000001699">
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    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="391" mass="43795" checksum="FD7EBD060574513B" modified="2008-04-08" version="1">MEIAPPESDTVRLNKTYALQHERDTQDTMDVQTAPRSIPSTESSNNYSNAILQDAEPQPSLDATTEQVWVQRALAEMTDMLLLLRRDGTVLYASPSCKWITGYESKQIERDALSRFIHDDDKSVFTRQLEECIATARPLRCQFRFYKPNNTFCVIDAHGHPHIKNENNTCNGVFLVCRPYPTKSSALLDSFLEHKIENIRLNQRISQLRAEEEEDTNASRQAYLKQISGPSAQRQNLPPFGSYDATGSGEENESSDTVNTDDGEPGSLLESTMRQAQDMTHIDGIEMMTGLRYREGERSHGLSTGMRQGCLVNCDIDTATIEQQVQSAQEIDRRKRLKGEYLCTDCGTSDSPEWRKGPDGPKTLCNACGCNAVGQEREETSGIKLSINPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y527</accession>
    <name>B0Y527_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hsp70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_071170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y527"/>
    <dbReference type="HOGENOM" id="CLU_009958_6_5_1"/>
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    <dbReference type="PhylomeDB" id="B0Y527"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Actin, Chain A, domain 4"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="624" mass="69501" checksum="5F8784C842A56CC0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y531</accession>
    <name>B0Y531_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein NO VEIN C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_071210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y531"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071210"/>
    <dbReference type="HOGENOM" id="CLU_927413_0_0_1"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33547" checksum="2D340A55554F412C" modified="2008-04-08" version="1">MSFAVVFLTPEDFIDECLDRHGIVRVPPDIAILPESEATDMTISPSRIEEQDVVSASDEGRESGDDFLYTPRDSSRSSPGDSIDVPRTIVAHNRISAPPPRLLTVPSPDWPSPDEAPRPFSERHSYIQLLDKIIRLARPLTLAEALQRPMTTVRSSIDTSHDGAFGIRSENQLAHDIKIGAAGELFVFELLSSDLPGFSRDNWRSTIRRHISVHPDYYDLTPWSGVETADVVYRDISSALTTTLIDAGCLSHARWHGSNPTYYIEVKTTTGECGSAFFMSKSQYRRVRLRTPTLHRALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5M0</accession>
    <name>B0Y5M0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_063860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5M0"/>
    <dbReference type="SMR" id="B0Y5M0"/>
    <dbReference type="HOGENOM" id="CLU_115154_1_1_1"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5M0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099617">
        <property type="term" value="C:matrix side of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="93" mass="11022" checksum="F8110962488CCDE1" modified="2008-04-08" version="1">MQAVKLIILRFDDLIPEESDVVQTALKRLPPKEAYDRVFRIRRAFQCSVSHTLLPAHEHTKPEEDVEYLSPIIREIERENKERVDLDTLVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5M8</accession>
    <name>B0Y5M8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-glycosyl-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_063940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5M8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063940"/>
    <dbReference type="HOGENOM" id="CLU_017872_4_2_1"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5M8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="411" mass="47157" checksum="730343BA8F4A5A8A" modified="2008-04-08" version="1">MLLPKGGVTWKSAKARLPPWRAVVVLLTRPRFLISLALTGILILLWRGISKSASGMQNFYCYGPPKSPMEMTINEMNAWMAHTQTPVIFNHHEPYVVNDSSIINVDLNGIQSTRAAKENKERVLILTPLRDAAPHLEKYFDLLYNITYPHELIDLAFLVGDSQDDTLAVLARELKRIQDQVEDKIAFRSATIIQKEFGAETGMNVEDRHSFAAQGPRRKAIARARNYLLYSALKPDHSWVYWRDVDIVDSPPTILEDFISHNRDILVPNIWFHRYKDGRDIEGRFDYNSWIESDKGRRLRQTLDPDTILAEGYKEYDTGREYLVGMGDWRKNKDEEVELDGIGGVNILVKADVHRSGINFPPYAFENQAETEGFARMAKRAGYEVYGLPNYIVWHIDTEEKPGNLGDRKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y613</accession>
    <name>B0Y613_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GPI transamidase component PIG-U, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_065300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y613"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065300"/>
    <dbReference type="HOGENOM" id="CLU_030193_0_0_1"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="PhylomeDB" id="B0Y613"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="423" mass="47198" checksum="B452C80B71A2E076" modified="2008-04-08" version="1">MPVDRRKVAVFGGAFVLRLLLLLLFPSLPDLLTGRVEVSTPVNSFKRLQEGLFLYTHNVSPYDGGVFHQAPLLLPIFALLPNARDYPLATAVFYALLDLVNANALVTISDSNQGISGRLYTTLRKDIKWGGVDVAAWYLFNPFTIAACLGRSTSAFTSTAILYALSNAVTGNSFNAMLALGCASYLSIYPALLFIPLVLLCYDRRAQVAKPSSGVAIFAIQHFGILLLGVGGLLSLSYLVVPDFQQFISATYGFQLLVPDLTPNIGLWWYFFIEIFDSFREFFLGVFWLHLTGYVGGLTVRLRKQPLFVLTSLVGIFTIFKPYPSISDASLYFALLPLYRHLFPLMRYTFFAISALLYATLLGPAFYYLWIYAGSGNANFFYAITLVWSLGLSILLADTIFAALRDEWEQENPEMRGKDIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y680</accession>
    <name>B0Y680_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_065970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y680"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065970"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B0Y680"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF15">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="530" mass="58074" checksum="681D661A0A0CC460" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y692</accession>
    <name>B0Y692_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">60S ribosomal protein L25, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_066100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y692"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066100"/>
    <dbReference type="HOGENOM" id="CLU_076154_0_0_1"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="PhylomeDB" id="B0Y692"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="199" mass="22840" checksum="A65F333C3CCFC87E" modified="2008-04-08" version="1">MSATTAATDLVSKLPLRLRNFFARYPPQIYSAAVRPPITEPETAAEESLPSPYTPNRDAKGFKKPDPKAFSPSKALLYSNPEHPNPFLPRKNFRNGKWIGPPIGLRRQAELVKLAIKYNVEALLPPGRKSTEYKETRRAERGLAIKGTGVGQKVKGHKWERTMEARLEDRRKAMMEMPEMIRLWKQRGHGRGWKQWPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y694</accession>
    <name>B0Y694_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-splicing ATP-dependent RNA helicase PRP28</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing ATP-dependent RNA helicase prp28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AFUB_066120</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y694"/>
    <dbReference type="SMR" id="B0Y694"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066120"/>
    <dbReference type="HOGENOM" id="CLU_003041_11_3_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="PhylomeDB" id="B0Y694"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="395"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="606"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="113"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="760"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP50279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="796" mass="88337" checksum="1E30167E3EC71A33" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6B5</accession>
    <name>B0Y6B5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_066350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6B5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066350"/>
    <dbReference type="HOGENOM" id="CLU_070380_0_0_1"/>
    <dbReference type="OrthoDB" id="4475042at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="303" mass="33527" checksum="FC3E230EC5B631A6" modified="2008-04-08" version="1">MSSTIHNGVKSENRVLIRGNEHSIPPRQKSPKRLKEQSVFPLAHPPPKPTQCLRLTPKLLLQIQHLSPKSTRPLPVLEVWQPSRFAARPCATLPKLHAGDMYITQSEAYASLSGENHHPNSGLEAEAEASSLEAVVGVIYHPPAQKTKARKEGPGPAQAEAEVHFPLTRRAWSASVTAEGWYRFQGRGEAGEYVLEWKRRGEKERSRSFSSSSTDRAPRAAADSRFVLGIVDMRTRRAARVASLTKKGFEVGCWERLPLEGLQECVGSSTDESDPSDGQFRTAVYTMVLTTGVWVAAQEDWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6N3</accession>
    <name>B0Y6N3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_067560</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6N3"/>
    <dbReference type="SMR" id="B0Y6N3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067560"/>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6N3"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="59"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP50418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="463" mass="50572" checksum="970321DDDEB25B48" modified="2008-04-08" version="1">MCPGADNEPNGHTNGANGTVPHPGFTAVETRQNPHPSASRNPYGHNVGVTDFLSNVSRFKIIESTLREGEQFANAFFDTEKKIEIAKALDDFGVDYIELTSPCASEQSRKDCEAICKLGLKAKILTHIRCHMDDARVAVETGVDGVDVVIGTSSYLREHSHGKDMTYIKNTAIEVIEFVKSKGIEIRFSSEDSFRSDLVDLLSIYSAVDKVGVNRVGIADTVGCASPRQVYELVRVLRGVVSCDIETHFHNDTGCAIANAYCALEAGATHIDTSVLGIGERNGITPLGGLMARMMVADPEYVKSKYKLEKLKDIEDLVAAAVEVNIPFNNYITGFCAFTHKAGIHAKAILNNPSTYEIINPADFGMTRYVHFASRLTGWNAIKSRAQQLNIEMTDAQYKECTAKIKALADIRPIAVDDADSIIRAYYRNLKSGENKPLLDLTAEEQAQFAAKEKELAGSGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6R1</accession>
    <name>B0Y6R1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_067840</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6R1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067840"/>
    <dbReference type="HOGENOM" id="CLU_059260_0_1_1"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6R1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="159"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP50446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="311" mass="35299" checksum="84F19CF16E179D40" modified="2008-04-08" version="1">MASTITLVVQPRGKPIRKLPKELQIDPNAPTQEIYTSLAEASGFSIHRLRITKGSDRTVVPNSKGMTANDIGLRDQSVVHVKDLGPQIAWRTVFIIEYLGPLLIHPLFLFPLRPYIYYNFDKPLPEPSGLQLLVCGLLTVHFVKRELETLFVHRFSNATMPVRHIFRNSAHYWVLAGFNIAYWVFRPDAGAATNEPNPALLYSGLTLFVFGELANLNTHLVLRDLRRPGTTERGIPTGFGFNLVTCPNYLFEIIAWIGVYLVSGMSWSVLFFITIGGSTMASWAAKKERRYRKEFGDKYKRKRFVIIPGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7F6</accession>
    <name>B0Y7F6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3HC zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_073640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7F6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073640"/>
    <dbReference type="HOGENOM" id="CLU_031412_0_0_1"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7F6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="275"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48621" checksum="C9AFB90C0904AA41" modified="2008-04-08" version="1">MSYAVETKKRKFHRMLESLTKPSTVEPAAKKIPASPSPARERLPADLSIKKVRLSDKDESNFAAVGRSILKARASSKGSTISSATRPSFVPWDRERFLERLETFRRVDRWSPKPAVISEVEWAKRGWICTDVSRVSCVGGCGGSVVVKLPDELDELDGYALDKVQERKEVPTIHRLPLTNTDTAIASLQKRYSNISKIADKLPAEDIIRTPESFNLDDVLKIWPRESFETGDGLRSTESQREQQDQSQDQESSEEIRGESSQVAPAPSKPIDRAAFALAFFGWDAVSNETAGLVGCSACFRRLGLWMYKPKDNGDATVYDALDVANEHMEYCPWISGKAQSGTGRATEKQAELRSGWELLVQALKVKHRRQVRSSTSMDTLRAVSETPSGDFPVVDEVSEEQKKASDREWWAKLRRMRQVLNVKSPHAKKSVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7G5</accession>
    <name>B0Y7G5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_073730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7G5"/>
    <dbReference type="HOGENOM" id="CLU_014254_3_0_1"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7G5"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="114"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="501" mass="55135" checksum="D2EE57AA456F839D" modified="2008-04-08" version="1">MITEPTMTVPYTTKRTASDLGPRRLRADNINPNVKAAKYAVRGELAVKAEEYRVRLAKGDKSLPFDSVIFANIGNPQQLDQKPITFFRQVLSLLENTALLEKPEVLRSSFGYNQDVIDRAKKLLADIQSVGAYSHSQGAPVIRESVAKFIEERDGFPANPQDLYLCAGASSGVSTLLNVICNGPTAGVLVPIPQYPLYTATLSLLNAQCVPYHLEEDKAWGTDVEAIRQSLVRAKAEGTEVRAIVVINPGNPTGASLSPEDIKSVLDIAAEEKLVVIADEVYQTNVFVGEFTSFKKRLRQLQQEVPGKYDNVELASLHSVSKGMVGECGHRGGYFELVGFDPLVAAEIYKFVSIMLCPPVIGQCLVELMVNPPKKGEPSYELYQKEYNSISDGLHKRALALYEAFKQMEGVECQEPQGAMYLFPSITLPPKAVEAAAAEGRNADEFYCLRLLDATGVCVVPGSGFGQKENTLHFRTTFLAPGTDWVERIVKFHAEFMAKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y849</accession>
    <name>B0Y849_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small oligopeptide transporter, OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_076100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y849"/>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="498"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="542"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
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        <location>
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            <end position="646"/>
        </location>
    </feature>
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        <location>
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            <end position="712"/>
        </location>
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            <end position="25"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="751" mass="84102" checksum="C7BEF25C59170CC2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y862</accession>
    <name>B0Y862_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spherulin 4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_076230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Spherulin4"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="137" mass="14972" checksum="1F3CD169A946D34B" modified="2008-04-08" version="1">MPQCFEHSADTLMTFEQSYDTYMNKYIPNPGWTPKDPRKFWHIIYGVPEADAGKVAALALKRGAGLIHITNDVLPNPYDTLPDEAYMKAITDTIKGGGPDVADPTPYPADGQATFPLGPLSVTASGLFLREPQVGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8J2</accession>
    <name>B0Y8J2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_077530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_043564_0_0_1"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="436" mass="48157" checksum="5DD7C07DDBAE52FA" modified="2008-04-08" version="1">MGLSLLRKTASPHDTLFYTVCVNSMAYKFINCLLMDEDDGQLSQMLRERAAKYKRTAQNALRRIPLLTSPSLALLQATLCGIFLCQGSGETQLCCDLTRVACRVCVDLRLHAAANSQGVTEEEYFCVMWCYMLDRNYAWKLGRFDCFLSVVPGIDDTPVSELFSIYMELAHVQSVLIPFLNDESFSERETAGQSFSHVSPPSPQWKGLDVRCEVAALDFGFHSIMTTILHLTQVKSGEIHGAGELNLQSARQELSALVSLCRPSDHQRTAAFLHWTLLYYPLTACFVLFCNAVATSHLGDFHLLKTVANCLIQSGTVSQPIATLQRLFHEFVLLSQTFISGPGSMAPVDDGVLEKRSNLTQEPTPPCSSLSLYGIDSAPGQETTLSGADDYFYSSSSSVFDQMLSPGELAFLNGSHSEGNLASEMYGYQQCNLWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8Q0</accession>
    <name>B0Y8Q0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_078130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8Q0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078130"/>
    <dbReference type="HOGENOM" id="CLU_055859_4_1_1"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760774" evidence="3">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="288" mass="29803" checksum="706FD12BBCB5268F" modified="2008-04-08" version="1">MSLSAICLMLLVTLTPVTATCYWPNGDTDNNYTPCPNSKSCCLKGEACLSNGLCYGAKLNIAYRGACSDKSWPAKDCPHVCLDSIPDHWANLYSCPNSSTNVFTCGYAGWATDVCSANLGQWLWVSGDVEVAKNGNTSPSASASASTVLDIVTTTSSGSGLSTGTPRGTITGEIVTTTESATATASGTGTETSSPRPSDTSISAVTLGAGLGVGLGVPLLVVSGLLIFFMRMRRRAPAAPAPPVSEKVYPGAVYDPGAAEIATQRHNMVTELEGSGRNLPDRPELYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8Y0</accession>
    <name>B0Y8Y0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Patatin-like serine hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_078940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8Y0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078940"/>
    <dbReference type="HOGENOM" id="CLU_003059_0_1_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8Y0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="233"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="5">
        <location>
            <begin position="237"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="5">
        <location>
            <begin position="400"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="682" mass="77198" checksum="BAFE314A11FE9EC8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9E9</accession>
    <name>B0Y9E9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_080790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080790"/>
    <dbReference type="HOGENOM" id="CLU_007091_3_0_1"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9E9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="755" mass="83925" checksum="45F4C1EABB14E636" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA11</accession>
    <name>B0YA11_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">High osmolarity signaling protein SHO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Osmosensor SHO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AFUB_082970</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA11"/>
    <dbReference type="HOGENOM" id="CLU_003674_0_0_1"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="PhylomeDB" id="B0YA11"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11774">
        <property type="entry name" value="SH3_Sla1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000256">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 19" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="400"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="190"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="522"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="720"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="989"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1023"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP48854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1168" mass="126557" checksum="C5977ABD5B5CE4C9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA56</accession>
    <name>B0YA56_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_083480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083480"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B0YA56"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-18647"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07090">
        <property type="entry name" value="ALDH_F9_TMBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000014">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="499" mass="53970" checksum="AFE80E5D2F25065F" modified="2008-04-08" version="1">MADLPFAPRHPYYDGKVQLASSGRTFRTINPADNTPLAEIHVASNSDTDAAIAAADRAFPLWSQTPHIARARILQKAAALLRERNDELARLETLDSGKAYSETSTVDIVTGADVLEYYANLVGGGGLNGETTHLREDAWVFTKKAPLGVCVGIGAWNYPLQIALWKSAPCLAAGNTMVYKPSEYTPLHAQMLAEIYREAGLPPGVFNVVYGAGDVGAYLTAHPLVAKVSFTGQVSTGMKVAGSAAGQMKYVTMELGGKSPLLILPDADLENAVNGAMMANFFSTGQVCTNGTRVFVPRGMKSAFEKALLDKMQYIRPGPLFDNATNFGPLSSALHLEKVTSYIRHGIETDKATLLYGGLGKPSLPKDLENGFWVRPTVFTDCTDSMRIVQEEIFGPVMSILYYDTVEEAVRRANNTELGLAAGVFTRDLNMAHRIIDQLQAGITWINSWGESPAEMAVGGWKKSGVGVENGRRGIEAWVRNKSTLVDMNGRVATVFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAX9</accession>
    <name>B0YAX9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_086200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086200"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B0YAX9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="14"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="988"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2382"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1157"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1020"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2462" mass="266597" checksum="340137E65C8BEBFF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBC4</accession>
    <name>B0YBC4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_092310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092310"/>
    <dbReference type="HOGENOM" id="CLU_1360127_0_0_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B0YBC4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="3">
        <location>
            <begin position="62"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="201" mass="22339" checksum="F0A79FE8CE72853C" modified="2008-04-08" version="1">MSVANKILILDTHESEQRPVAEEPMKMDSVLVHAYEQEANDADGVDQVRDEYSGSMAGVKSTYAPNMRVASNEKSGNRALAKNIAVGMRLPSFPVVNQADGSTIPLLNLMSSGGCWRLIVFSGDLRRPRVCERLTSFAESFTQHSHLAHQQQTESPQRRGPPLQTLLVHANPRMSISLLNLPIIFHPSDGELGRDYWKTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBK6</accession>
    <name>B0YBK6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_086950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086950"/>
    <dbReference type="HOGENOM" id="CLU_106778_0_0_1"/>
    <dbReference type="OrthoDB" id="5308323at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758841" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21384" checksum="27D5CF91DE24E08B" modified="2008-04-08" version="1">MFKSAALVSLLLAAATASPTPSEDLEARACAGLGPSVIDVLRVSTPDNASPGQQFTLSRAGYPPYNTQISAITFNYIPPNATGCMLEIDIPALSQPNQIAEGATQVDIWTTDPWNYLSLPTYNNPPKRREMVGTYIFPTQPTTEASKTIIASNTCSDTMSFLVELSNWQQQSGSVTFYNTLGGKQGIEPTGFKMIYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBR2</accession>
    <name>B0YBR2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_087540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087540"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="PhylomeDB" id="B0YBR2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="51"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP48043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="545" mass="60249" checksum="8560604ABBC3F929" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC52</accession>
    <name>B0YC52_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable feruloyl esterase C</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_088950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088950"/>
    <dbReference type="HOGENOM" id="CLU_1184785_0_0_1"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="PhylomeDB" id="B0YC52"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF2">
        <property type="entry name" value="FERULOYL ESTERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032993765" description="Probable feruloyl esterase C" evidence="11">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP48183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="234" mass="25681" checksum="9898825BA76FE81A" modified="2008-04-08" version="1">MKVHFDILLSIASLATATASAGCGKPLPNDQGAEGIYPTDFTTSDDTLRPYIIHIPSNYDENRAVPLTFSFHGRSKTAESQEQLSQFSNEAWNPDAIAVYPQGLDNQWQGDPDSSGVDDVAFTMEMLDNFEKRYCIDSSRVYAAGKSNGGGFTNLLACDPTAFKSIDYCGICPRFGCLLPGRTRGRLQSRKARPTRQSLTMEVVDAESVYPLCHISSGSEQRGTDSSCRNKLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC74</accession>
    <name>B0YC74_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_089180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC74"/>
    <dbReference type="HOGENOM" id="CLU_052388_0_0_1"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="PhylomeDB" id="B0YC74"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001208">
        <property type="entry name" value="Tetratricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="4">
        <location>
            <begin position="102"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="319" mass="35602" checksum="550738E1E133427D" modified="2008-04-08" version="1">MSRTAPELHAIHGSDLFSSLHLSQQAPLILNRRLTSETNLKSTLLLSPEKFEEYREIEQLLLACLQTGDDRSALSCLNQLEQRFGASNERVLGLRGIYEEAVAEDQSSLESCLRKYDTLLLENPANMPVLKRRVALLRALSRPTDAIHSLIDLLKAAPTDAEAWCELSDLYKSQGLGLQAIFCLEEALLIAPNAWNIHARLGELQHLVAGSSDPEQSYHLLRGSIRSFSRSIELCDDYLRGFYGLASVSEGYRTYLQDSSLSQADDSLSVVLLERLSAFAKTRIEGIVKERSKGRIHSEYSQGELIAAKELLDRLNVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCE5</accession>
    <name>B0YCE5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_089900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089900"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="PhylomeDB" id="B0YCE5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="367" mass="38565" checksum="C67C00CE7AD8949A" modified="2008-04-08" version="1">MPLPQLLVGKVAAITGGLTGIGRAIALEYLRHGARVAVNHLGRPDEEPLLEAMLKDVGEITGSEGGRFITIAGDVSQPETGRDFVAKTVEAFGRLDIFVSNAGVCKFEEFLEVDPPLLGHTVNTNLCGAFYATQAAARQMALAQSPPGGSIIGISSISALVGGGQQTHYTPTKAGVLSLMQSTAVALGKYGIRCNALLPGTIRTQLNDEDMSDPVKRTYMEGRIPLGRLGQPPDLAGPAVFLACDELSGYVTGAQLLVDGGLLHIHILILYALAATSPQNPFFCSSVNPRLSRTFSTTLFQRFQESSLPPPPILQTGQSDPNMTRSGPNTSKTTSVHGCSLSTRDAMSGSGVEASGGNSEKPPESFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCF5</accession>
    <name>B0YCF5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_090010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090010"/>
    <dbReference type="HOGENOM" id="CLU_032488_0_0_1"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="PhylomeDB" id="B0YCF5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="672" mass="74765" checksum="AC228A12B3DD390D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDR6</accession>
    <name>B0YDR6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_096520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096520"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="PhylomeDB" id="B0YDR6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000425">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000540">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="510" mass="56302" checksum="B2C6C758E31A42C2" modified="2008-04-08" version="1">MIQVPSATGDPERLRADGELFDKDAALAVVSDVAMEIDPEVEKRVLRKIDLFFMPAMLVGYGLVYWDKAILGSATLFGMTNDLHLVVIDSSTTPPSKDTSRLSWATSIFYFGMLAGLYPMTFFLQRFKIQHVFGPIVMLWAVTCAATAGVTTWQGLFAQRFFLGFVESVVPTGFMTIVSGYYTQKEQSLRQAWWFSGTGWFTIIGGAMNYGFGQITSGSLKRWQYIYIFAGVLTFLFGIWCCVMPNSPVSASFLTPEERVVAVERLRRGQTGVRCQKIKLSQIKEAALDIKLYLIAIMMAAAYTINGAISGFGPLIVSTFGYDTLDSILFQFPVGGICVIFIPLCGYVASRVPHTRIPMLIACCLPVIAGCALIWKSPWGYQPAAPVVGYALTGFFGPVVSLIITLGASNVAGATKKTVMAATVFVAYTVGNIIGPQLVKTQTVRQHYPELWTGLIICYGVTIAAAGVLYGILRRENRRREAMELDESQRDKMAFNDLTDKENPFFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDV3</accession>
    <name>B0YDV3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide mating pheromone Bbp2-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096900"/>
    <dbReference type="HOGENOM" id="CLU_2482959_0_0_1"/>
    <dbReference type="OrthoDB" id="4509625at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760854" evidence="1">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="87" mass="8830" checksum="9144CEC110174E87" modified="2008-04-08" version="1">MKFSIIALTFIGSALAAPGASIPTPSTPAAPSCAASSSHIASSTASPSATPIFQPGCDIEHVGNNGKHLGWCKKARHYGMYNNGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDX6</accession>
    <name>B0YDX6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_097140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097140"/>
    <dbReference type="HOGENOM" id="CLU_2996155_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="57" mass="6625" checksum="C4B1A03626E321F0" modified="2008-04-08" version="1">MEPTEGTKTRGFSICPWDHYIESSSYFSSTFFFIQSQLEPKILNKTATQWDTSKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE10</accession>
    <name>B0YE10_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_097450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097450"/>
    <dbReference type="HOGENOM" id="CLU_594427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="50776" checksum="88FF7250F9FEAC2D" modified="2008-04-08" version="1">MDISLALQTLLSAPEGSLESHRSQALSLAETIWRSLRATSTDATASGLTSSYNSEDESDSTETSGPRGPSSVSSADIVPSLNDGLRPVRRTQIRDLRPQRLLTTMEERISDMKKISEKGARMVVEEVLISFVDEDGRLSDVTRVVGKKNAGDEERLIQCLAQRALALEYTQWELQVRRLKKTRVQELAERLSNTNSQSGHIAQSIRCGIKQLLQEKLLSDKLSEGAECEARILNFLMEQSRWISECQAVYNGSASTNERSAKRQRQDEDASSISGSLRELYPNQSFRPIQKKPRAAYSQLPSCSTVQRLLSPTVESHQNLFDSAEATHSQTVTGACGPAFVSDNSGPSRTPIEQRNLPNEQQVLSFDNSVVTPNEDSEAIQHGTGVTSQESSAFGQYQNSSILPEQLNPGFNSLGYYHNTAYPPVPFNNPPLVGFSDWGLVNWDLQGFQDVCFQPISDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEP7</accession>
    <name>B0YEP7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_099930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099930"/>
    <dbReference type="HOGENOM" id="CLU_031217_0_0_1"/>
    <dbReference type="OrthoDB" id="2099887at2759"/>
    <dbReference type="PhylomeDB" id="B0YEP7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF1">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758938" description="Regulatory P domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49470" checksum="B755556C6FD40A8A" modified="2008-04-08" version="1">MKFTAFSLLSLACAAVASREGEAAMDRLMSVKVEERERFRAEGLFDANQYPDLGSQKCVNGKAGEYSCENVDLLGFLSHQAMGSKTREGNDIWGWTSPDGREFGIIGQTDGTAFVEVHADGSLDYVGRLPTQTQSSVWRDMKVIGDHVYIGSEAPGHGLQVFDLKKLLRTDPSKPTTFSISRDLTAWYNAFGSSHNIVAHEETNMIYAVGTTRSHSCAGGLWMVDVSNPAKPISPGCVNQDGYVHDAQCVIYKGPDKKYNGREICFNYNEDSLTIVDVSNKKSPVQISKTPYAGSSYTHQGWVTDMEDMSYLLLDDELDEKDGTGVAANGHTTTYVFDIRNLAKPKHTGTYQSPVKSIDHNQYVLNGLSYMSNYSSGLRIVDVRSVTQDPTGAKFKQVGFFDCHPDDDAEGGKVQFVGSWSVYPYFKSGNILLNSIERGVFSLKYTGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEW0</accession>
    <name>B0YEW0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS maltose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_100670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100670"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_3_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B0YEW0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="537" mass="59700" checksum="CF32F4D540580DDA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEX1</accession>
    <name>B0YEX1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_100790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100790"/>
    <dbReference type="HOGENOM" id="CLU_010931_0_0_1"/>
    <dbReference type="OrthoDB" id="5321461at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055525">
        <property type="entry name" value="DUF7099"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055526">
        <property type="entry name" value="DUF7100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055527">
        <property type="entry name" value="DUF7101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23388">
        <property type="entry name" value="DUF7099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23391">
        <property type="entry name" value="DUF7100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23392">
        <property type="entry name" value="DUF7101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7100" evidence="3">
        <location>
            <begin position="13"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7101" evidence="4">
        <location>
            <begin position="347"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7099" evidence="2">
        <location>
            <begin position="601"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP47084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1046" mass="115406" checksum="5727ABE852A9513C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF17</accession>
    <name>B0YF17_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding oxidoreductase CipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_101250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101250"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="PhylomeDB" id="B0YF17"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="56"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="382" mass="40887" checksum="71DC46924BF74041" modified="2008-04-08" version="1">MALHSVVPYSLISRNSIISIYTLKTASSVSQSTGLFPKLVKMAPTNAAAWLSEEKKHPFEIKESPLGKPEANEILIRNHALAINPIDGLIQTKAFFPLHYPIILGQDVAGEVISIGDKVTRFKPGDRVLGHAVGLMAGRNEACGFQTYTILQDNLACEIPENISYEQAVVVPLCLSTAASGMFQEDFLHLNLPTEPRTASTGQTLLVWGGASSVGSNAIQLAVAAGYEVITTASPKNFDYVRRLGASLPFDYGSPTVTEDIAEATKNKVLAGAIDCIGTTTTATCVDIVRRSQGKKFVATVKGGFAPPTDGIQVKHIFGTTLKDNFVGKTVYKEFLPRALQSGAFLPSPEPLVVGTGLEKVQEAVDLYWKGGISAKKLVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM15</accession>
    <name>B0XM15_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_001670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001670"/>
    <dbReference type="HOGENOM" id="CLU_018351_0_0_1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72489" checksum="73AA089BBD801BA5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM59</accession>
    <name>B0XM59_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">APSES transcription factor Xbp1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_001060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM59"/>
    <dbReference type="HOGENOM" id="CLU_027582_1_1_1"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="122"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="497" mass="55409" checksum="2EBC03FA26B823C1" modified="2008-04-08" version="1">MASIASLLNPLPGPSQLSSPTRTLASSAASMASNTPRPKRPKVAKDAAIFTKAKPRGEVRYPPCEERDEELARMHREFRIHPMGDISEYARHIPYNSDKKSFQERTGRESFEGESHSEQHTTYPRGVYAYKISIVFQYTFKLPGDEKEWIVMWDYNIGLVRTTHLFKCNDYSKMLNANPGLREICHSITGGALAAQGYWMPYEAAKAVAATFCWKIRHALTPLFGLDFPSMCIHPQDRGRFGRMVIDPAIVRKATETANYYRILELQSPSYSSLHLTRTGGKFRPNSTGSSGFVKRLIPRSHEHRYSESRTGYGSSSPECHGDVYCVSPVSPFRNSFTPVNTPRSSEVICSKLPSSRAIAATTAPMPDREHTAGSEEDSGSDETGSSTMYTESTSTTTEVLSVDLDADDDDDDEDYREKSDRSDRSSVNSSIPDHNRKIETRSRGKHSSALFAREVKAAHALLSLHMQEAMGSDGDEEPLLTASRGLNSRKRRRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM88</accession>
    <name>B0XM88_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xylosidase/arabinosidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_000220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000220"/>
    <dbReference type="HOGENOM" id="CLU_016508_0_0_1"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="PhylomeDB" id="B0XM88"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="327"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="513" mass="57346" checksum="B96DD7C15307BF14" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMV0</accession>
    <name>B0XMV0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_014260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014260"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="PhylomeDB" id="B0XMV0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="483" mass="54496" checksum="56A1C99F482F6BF3" modified="2008-04-08" version="1">MGSTTTSTLPPDFLWGFATASYQIEGAVDEDGRGPSIWDTFCKIPGKIAGGASGEVACDSYHRTHEDIALLKECGAKAYRFSISWSRVIPLGGRNDPVNEKGLQHYVKFVDDLLAAGITPLVTLFHWDLPDALDKRYGGLLNKEEFVADFANYARVMFNAFGSKVKYWITFNEPWCSSVLGYNVGQFAPGRTSDRTKSPVGDGSREPWIVGHNILVAHGAAVKIYREEFKPRDGGEIGITLNGDWAEPWDPENPADVEACDRKIEFAISWFADPIYHGKYPDSMVKQLGDRLPTWTPEDIALVHGSNDFYGMNHYCANYIKAKTGEPDPNDVAGNLEILLQNKNGEWIGPETQSPWLRPHPIGFRKLLKWLSDRYNQPKIYVTENGTSLKGESDLPVDQIVNDDFRVQYFREYIAAMADAYTLDGVNVRAYMAWSLMDNFEWAEGYETRFGVTFVDYANNQRRIPKKSAKVLREIFDQYIEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNB7</accession>
    <name>B0XNB7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_004390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004390"/>
    <dbReference type="HOGENOM" id="CLU_039465_0_1_1"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="PhylomeDB" id="B0XNB7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000060">
        <property type="entry name" value="TBC domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="67"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="418" mass="48005" checksum="8EA493971D09E913" modified="2008-04-08" version="1">MDDSSTTQPEGNLDEKQEVPRSDPIGKLLDSDSENIARPKKEEAIRKACDLRDLDALVSYATSEGGLLNDDLRRLAWPIFLRSDRDVQDSNFASWEDLPSHGDEDQVQLDVNRSFVYYPQCPEDELLLKKDELSILIRRVLREYPMLSYFQGYHDIAQVLLLVLGEKEAAPAVTNISLFRIRDYMLPSLSPALKHLQLIPAIIEKADPALREHLGGIKPFFALAATLTLYAHDIQEYSDIARLFDFLLATEPVVSIYLFAAIILSRKKELLEIPADEPEMLHFTLSKLPQPLDLDSLISSAMRLFNDYPPESLPFRAWKRISQHSVLKSSRAPFNKQTRDEAIRLLEKQVRQLHNEELRDKALAFLWHHRTTVGSVTVAIFIGVMSIWIRKKGFDTPLWSYFAELKTSFRKWLPMISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNE7</accession>
    <name>B0XNE7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SH3 and Ded_cyto domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_004680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004680"/>
    <dbReference type="HOGENOM" id="CLU_000595_0_1_1"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="PhylomeDB" id="B0XNE7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="624"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1448"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1853"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1923"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1855"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1932"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1972"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2014"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2034"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2064"/>
            <end position="2079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2079" mass="230565" checksum="8CA363FF22F0E5C1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNI2</accession>
    <name>B0XNI2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_015240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNI2"/>
    <dbReference type="HOGENOM" id="CLU_011501_0_0_1"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="PhylomeDB" id="B0XNI2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Anaphase-promoting complex component Cut20/Apc4, putative"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
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            <end position="132"/>
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        <location>
            <begin position="285"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="735" mass="81438" checksum="0B9041DC42801F88" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNK5</accession>
    <name>B0XNK5_ASPFC</name>
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        <submittedName>
            <fullName evidence="7">Auxin Efflux Carrier superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_015470</name>
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    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_026460_1_0_1"/>
    <dbReference type="OrthoDB" id="2499604at2759"/>
    <dbReference type="PhylomeDB" id="B0XNK5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="567" mass="63009" checksum="F58CD6EF373B91D5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNS0</accession>
    <name>B0XNS0_ASPFC</name>
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        <submittedName>
            <fullName evidence="5">Calmodulin-binding protein Sha1, putative</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_005290</name>
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    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNS0"/>
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    <dbReference type="HOGENOM" id="CLU_005445_0_0_1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21223">
        <property type="entry name" value="CH_ASPM_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1015" mass="114158" checksum="5A3E24E8566612EE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNZ7</accession>
    <name>B0XNZ7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_016230</name>
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    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNZ7"/>
    <dbReference type="SMR" id="B0XNZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016230"/>
    <dbReference type="HOGENOM" id="CLU_095877_0_0_1"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="PhylomeDB" id="B0XNZ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000009">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="179" mass="20247" checksum="346421DFDDD08B7E" modified="2008-04-08" version="1">MIIYKDIISGDEVLSDNFKIKEVDGVLYECDCRKYLKRKNEDIQLEGANPSAEEGDDDAGGDGEEVMVHDIEDQFRLVWLKTEEGMKPSKDAFKSHLKTYMKKVLAKLQEKGVPEAEIDAFKKGAPAAVKKILANYDNYDVLMGHSMDGDAMHVLIDFREDGVTPYATLWKHGLEEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP99</accession>
    <name>B0XP99_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nonribosomal peptide synthetase sidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Siderophore peptide synthetase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_016590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016590"/>
    <dbReference type="HOGENOM" id="CLU_000092_1_0_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B0XP99"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000051">
        <property type="entry name" value="Nonribosomal peptide synthetase sidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000055">
        <property type="entry name" value="Nonribosomal peptide synthetase sidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000018">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000027">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000049">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000038">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000057">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000038">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000011">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000014">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000015">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000018">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000019">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000056">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF2">
        <property type="entry name" value="FERRICROCIN SYNTHETASE (NONRIBOSOMAL PEPTIDE SIDEROPHORE SYNTHASE ) (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="853"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="1979"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3099"/>
            <end position="3175"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3647"/>
            <end position="3720"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="4204"/>
            <end position="4277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP56937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="4763" mass="522415" checksum="FB4C4005BCA66CB2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPF0</accession>
    <name>B0XPF0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_006250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006250"/>
    <dbReference type="HOGENOM" id="CLU_039096_0_0_1"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="404" mass="45124" checksum="F6E9B73E46763E40" modified="2008-04-08" version="1">MNNLRGILPRFKSPSLSSARVLTRTTTNRSLTMATPLSSPSPRLERFQQAVESLYGSFSSIADPSAWTPPPSSGGHRGRYLWTDAFGVLTLITMHREYEKALAKAAQAPDDRYLVLARRVVATVHEVLGSTRDGKARLPGATAANPLGGGLRIGKMDEHGPDADGQYHHYLTVWMFALNRLSLATGDPAYNEQAVALAKAIHPRFFVHRESTRPRMVWKMAMDLSAPLVASEGNLDPIDGYVVFRLLQGAAKQVGRGAVLAEEIADYKRVMERKGQHFVSSDPLDLGMTLWTAHWFSEKEDWAARLAGRCFEQIYDLFEINRYLERNIKYRLAFREFGTCMGIQCQEEQTTEKDRSVDLKVYADAIIAAWDPYMELSLASDVTPDDLRPITRIMYAAALIPGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ58</accession>
    <name>B0XQ58_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_008810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ58"/>
    <dbReference type="HOGENOM" id="CLU_152663_1_0_1"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ58"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="81" mass="9237" checksum="D7DD000A251F8FDA" modified="2008-04-08" version="1">MSQSALFNFQSLLLVFLLIICTSTYAHSIMPGIMDRNQRGFFGIFWKCARIGERLSPYVSICCILMAVSTPRFYVILSNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQR8</accession>
    <name>B0XQR8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_010920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010920"/>
    <dbReference type="HOGENOM" id="CLU_013424_1_1_1"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="PhylomeDB" id="B0XQR8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000082">
        <property type="entry name" value="Endopolyphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760532" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="52"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="478"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP56382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="668" mass="76207" checksum="209A05AC684D7BC1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQW7</accession>
    <name>B0XQW7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_011420</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011420"/>
    <dbReference type="HOGENOM" id="CLU_008640_0_0_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="PhylomeDB" id="B0XQW7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030061">
        <property type="term" value="C:mitochondrial crista"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901612">
        <property type="term" value="F:cardiolipin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140523">
        <property type="term" value="F:GTPase-dependent fusogenic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180020">
        <property type="term" value="F:membrane bending activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097749">
        <property type="term" value="P:membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990627">
        <property type="term" value="P:mitochondrial inner membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990626">
        <property type="term" value="P:mitochondrial outer membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="236"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="801"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="895"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP56431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="918" mass="101404" checksum="DFF4EFE54F70C256" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR95</accession>
    <name>B0XR95_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_012570</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR95"/>
    <dbReference type="MEROPS" id="C26.959"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012570"/>
    <dbReference type="HOGENOM" id="CLU_007713_2_0_1"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="PhylomeDB" id="B0XR95"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="28"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="250"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="567"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP56546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="764" mass="82221" checksum="173D1E4F90704D12" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRC0</accession>
    <name>B0XRC0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arp2/3 complex subunit (Arp2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_012820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRC0"/>
    <dbReference type="SMR" id="B0XRC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012820"/>
    <dbReference type="HOGENOM" id="CLU_027965_0_0_1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="PhylomeDB" id="B0XRC0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="388" mass="43674" checksum="17896F4225B8B75C" modified="2008-04-08" version="1">MADMPIVLDGGTGFLKVGYAAQNFPEHQFPSIVGRPILRTEEQAGDIVVKDIMCGDEAAAARSMLQISYPMENGIVKKWDDMQHLWNYTFYEKMKIDPTGRKILLTEPPMNPLKNREKMCEVMLEQYNFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIIPVYESTVLKHHIRRLDVAGRDVTRNLIALLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDKKLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVDQPGMAELLFNTIQGADVDVRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWLTRVLQGDPERLGKFKVRIEDPPRRRHMVFLGGAVLANLIADKEDMWVSKQEWEEQGVRALAKLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSG1</accession>
    <name>B0XSG1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NTP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_027070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027070"/>
    <dbReference type="HOGENOM" id="CLU_315909_0_0_1"/>
    <dbReference type="OrthoDB" id="5415055at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="908" mass="100186" checksum="24C92901279FC59E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSX2</accession>
    <name>B0XSX2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 13">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_028100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 13"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSX2"/>
    <dbReference type="SMR" id="B0XSX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028100"/>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="PhylomeDB" id="B0XSX2"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120513">
        <property type="term" value="C:2-(3-amino-3-carboxypropyl)histidine synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="445" mass="49244" checksum="03287B6637F3BF28" modified="2008-04-08" version="1">MTEPLLSSAAPEMKMEETSSSSNLRQPKKRFVGRRTADAHAQKDASISSKDVESTSVQRVAPRRNPRTLNQVPPEILDDPEIQAAIELLPKNYSFEIPKTIHRIRTSGAKRVALQFPEGLLIFATTISDILTQFCPGTETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTQIKTLYIFVDISIDTSHLIATLERNFQPGKTIATVGTIQFNATLHGLKPVLERAGFKVVIPQIAPLSKGEILGCTSPQLSPTEIDILLYLGDGRFHLESAMIHNPTIPAYRYDPYSRTLSRETYSHDEMHALRRDAINTAKSAKKWGIILGSLGRQGNPNTMAMIENHLNERGIPFVNLLLSEIFPGKLASMSDVECWVQIACPRLSIDWGYAFPRPLLTPYEALIALGVREHWDSANSGVYPMDFYAKEGLGRTKPQQALQGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT12</accession>
    <name>B0XT12_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-rRNA processing protein Tsr1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_028500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028500"/>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="PhylomeDB" id="B0XT12"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000461">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="85"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="803" mass="90286" checksum="882905D5BBD025E6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT27</accession>
    <name>B0XT27_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_017790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT27"/>
    <dbReference type="SMR" id="B0XT27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017790"/>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="PhylomeDB" id="B0XT27"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000037">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF231">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758319" description="alpha-amylase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="15">
        <location>
            <begin position="523"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP53736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="630" mass="68512" checksum="C6283D8110DB880E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT82</accession>
    <name>B0XT82_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_018350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018350"/>
    <dbReference type="HOGENOM" id="CLU_010365_3_2_1"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="PhylomeDB" id="B0XT82"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000088">
        <property type="entry name" value="Ferric-chelate reductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF27">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="292"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP53791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="599" mass="66748" checksum="801C2FBABAC3EAEE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTD3</accession>
    <name>B0XTD3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_029010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTD3"/>
    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="PhylomeDB" id="B0XTD3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="171"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="766" mass="87341" checksum="C1408506098D5D53" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTM4</accession>
    <name>B0XTM4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fructosyl amine:oxygen oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_019110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019110"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="PhylomeDB" id="B0XTM4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000016">
        <property type="entry name" value="Fructosyl amine:oxygen oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF24">
        <property type="entry name" value="HYPOTHETICAL FRUCTOSYL AMINE:OXYGEN OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="445" mass="49379" checksum="6307CD78CE6C75E2" modified="2008-04-08" version="1">MAPSILSTESSIIIIGAGTWGCSTALHLARRGYKDVTVLDPHPVPSPIAAGNDINKIMEHSELKDGSSDPRSAAFSTFTRAALKAWKTDPVFQPYFHETGFIISGHTPALIDHIRKDEVEPSETNFVKLETAEDFRRTMPPGVLTGDFPGWKGWLHKSGAGWIHAKKAMISAFNEAKRLGVRFVTGSPEGNVVSLVYEDGDVVGARTADGRVHKAHRTILSAGAGSDSLLDFKKQLRPTAWTLCHIQMGPEEVKQYRNLPVLFNIAKGFFMEPDEDKHELKICDEHPGYCNFLPDPNRPGQEKSVPFAKHQIPLEAEARARDFLHDTMPHLADRPLSFARICWDADTPDRAFLIDRHPEHPSLLVAVGGSGNGAMQMPTIGGFIADALESKLQKEVKDIVRWRPETAVDRDWRATQNRFGGPDRIMDFQQVGEDQWTKIGESRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTX2</accession>
    <name>B0XTX2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cortical patch protein SUR7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_019400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTX2"/>
    <dbReference type="HOGENOM" id="CLU_059603_2_0_1"/>
    <dbReference type="OrthoDB" id="5419460at2759"/>
    <dbReference type="PhylomeDB" id="B0XTX2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000058">
        <property type="entry name" value="Actin cortical patch protein Sur7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758340" evidence="2">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="239" mass="26610" checksum="DF37D9A257C34A3C" modified="2008-04-08" version="1">MALSSLFFTASALLLMFLAFLGGARNSNPLDRIYWLEAATGNIPGAPALSRWTYWNLCAVNSEGHNECGKSYPDYPFDPPSHRNFNTHVNIPAAFIGTRHYFLTSRFMFPFHIIALFFATCSLLTGFLAMCTRIGNWVSAFSAYFALTFQTITTCLMTAVYVQGRDKFNNNGQSSHLGVKAFAFMWTSVALLFLSCVIYCMGGAVGRKDGGYSGREQRRRGFFNSHRSGSLRSNKETAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUH7</accession>
    <name>B0XUH7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C6 transcription factor (Leu3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_030930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUH7"/>
    <dbReference type="SMR" id="B0XUH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030930"/>
    <dbReference type="HOGENOM" id="CLU_702030_0_0_1"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="PhylomeDB" id="B0XUH7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="393" mass="43900" checksum="1A1D5656C93069FF" modified="2008-04-08" version="1">MALSPRAQTSSTRSSSRQSNRHREVYQGESSFILSVQEQNAESLLRCSRYMRMIADEMDPQSSLKRAKKACTECRQQKHKCDAYLNPEQPCTRCRKSQIKCVISDPFRREHKRQRRAELEHEANELRRQLQAAQAPAQAPNHHASPIAMLTAAAEMGVHSASSEVALRLPAPSAPALPTPPTPGPSPCAAALPVPSYAQQLLSSAGLEEPLAKVDIEPDDHRLEPTVPRTLNNVTIKAAEIDDLFQVFFREYSQFLPILDIGLTPNAYYSQSPFLFWAVIGVACRSYPKNPTLLTALSRGIVEMALLSALSTTPWHTVQGLLLLLTWPFAKDKTRSDVMFTLSGMMLHIAMQNGTHIPMSSHEFSRFKTPAPSETDMVRRSELWAHCVIAYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUN0</accession>
    <name>B0XUN0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_020650</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020650"/>
    <dbReference type="HOGENOM" id="CLU_000445_3_1_1"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="PhylomeDB" id="B0XUN0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000007">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000015">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000207">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="326"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="510"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="602"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="694"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="768"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="1146"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="194"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1318"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1337" mass="147465" checksum="567B6C0143B405FF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUU9</accession>
    <name>B0XUU9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_031510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031510"/>
    <dbReference type="HOGENOM" id="CLU_056749_0_0_1"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="PhylomeDB" id="B0XUU9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="306" mass="33724" checksum="FE725CCA69EAD0FE" modified="2008-04-08" version="1">MRFSGMASSSSPRSSPQKEVEHFRAIATEATTLARTGQWPHFRTVPKQFPPWPKTAPPASEGGIWGVQHLLHPQMPNRTEFARFYFSEKVLAVAEELLGVKGTSTEATEPLVMELFNLLVAPETKDFELRWHRDDIPETVSPEEEMRLLQAKSPQGRQSHAQYNLALCPDSSLIVVPGSHRRVRTETERSAGPYEPELPGQLVVELRPGDAVFYDSNILHRGVYKAKSQEGEETRLTLHGSIGLKVSASGSDADEKVRATAVLQHGVGSWVHHEDAAFGIGERAEKMRANLIALGTGEGVGYSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUX6</accession>
    <name>B0XUX6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_031780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUX6"/>
    <dbReference type="HOGENOM" id="CLU_016663_1_0_1"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="PhylomeDB" id="B0XUX6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04497">
        <property type="entry name" value="hPOT1_OB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000303">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000426">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="635" mass="72098" checksum="F3F619A3366027F6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUZ1</accession>
    <name>B0XUZ1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_031930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031930"/>
    <dbReference type="HOGENOM" id="CLU_053034_0_2_1"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="PhylomeDB" id="B0XUZ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="334" mass="37415" checksum="6D0D83D18313AD4D" modified="2008-04-08" version="1">MQAAQQSWELENTISLIDPQRDALYRYDEETHKALSAARPWAKDPHYFKSIRISAVALIKMTMHARSGGSLEVMGLMQGYILPETFVVTDAFRLPVEGTETRVNAQEEANEYMVSYLQSCRDAGRMENAVGWYHSHPGYGCWLSGIDVTTQDMQQLGGPFVAVVIDPERTISAGKVDIGAFRTFPKDYTRPKEGNEDEDYQTIPLSKAEDFGAYAHQYYSLEVSFFKSSLDTELLSQLWNKYWVATLSQSPLFTTRDYGSRQMMDLSQKVRRAARGIESSGSRGGATTPKDQQLEKIVRDGQRIVSEEVKGLLAAEVKMKLFQGIGEGTQTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVC1</accession>
    <name>B0XVC1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin monomer binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_032600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVC1"/>
    <dbReference type="HOGENOM" id="CLU_031995_0_0_1"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="PhylomeDB" id="B0XVC1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="199"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="311" mass="33864" checksum="4EBA1CD3687671B2" modified="2008-04-08" version="1">MQSGIAVSSELHDAFNNFSSDSSIFCLPVTITAESLTPLSPIRFSSPGAFYPSLSQLSSVLQPKTPLYLLFRRPESGSSSLCALTYIPSNAPVRAKTLFASTRATLVRELGSEKFATTIFATEEEEITSEEAWRERDAEKKGSGSKGDFRREDLMGDKERELEAVRRAEEEARSGTPGRDIGIGGSFARGGFGSGVQSGMRMTVDDDVKSALEGLQDGGLVQLAIDIPSETFKLAAAESGIDANSVQTHISSSSPRYTFYHYPETDTVFFIYTCPSGSSIKERMLYASSRMYALRVADEQGLKISKKVCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVE6</accession>
    <name>B0XVE6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_021980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021980"/>
    <dbReference type="HOGENOM" id="CLU_048926_0_0_1"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="PhylomeDB" id="B0XVE6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="133"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="39587" checksum="BD0729290A5A5082" modified="2008-04-08" version="1">MDISQETVDKIRRFAQKRQKAEEFYEEHSVNPANFDAYNRKLDETLAELQAQVKRHEDELRKLRMTTTIEFAQIGADPWARISEVRRAKKAYDSLLQSETRLPSPGSPLPSLLAVDEASRLVKESKTSISLTAEKLSADRQRLKAEEANLRDAQLIKDGLEKRIERLNAEKSSQVQKTPAQLAYDLVKEQQEKIERLDTTTEELKSSLYKFVEDTLAPMLAAENLGGPTVGDALEISDTTLKAGYTSHGKPKKPKTPAVGTSDSGQQRIDELVRRQTAQEGNEQATLLNKREAAAAEMRALLTALLDADYSYVDLPHESAASRFLVRAKVAQFHPRDARKLRLIDFGRSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVL5</accession>
    <name>B0XVL5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2 transcription factor (AmdX), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_032870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032870"/>
    <dbReference type="HOGENOM" id="CLU_008344_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="PhylomeDB" id="B0XVL5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="815"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP55223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1195" mass="130080" checksum="8599626BDB9BD31D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVL8</accession>
    <name>B0XVL8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_032900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032900"/>
    <dbReference type="HOGENOM" id="CLU_065859_1_0_1"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="PhylomeDB" id="B0XVL8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012790873" evidence="1">
        <location>
            <begin position="16"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="265" mass="28827" checksum="8D94E08A125439C2" modified="2008-04-08" version="1">MRLPLLSFFILPLYALPTPSHSPKPPFFLLAGDSTTAKQSSNGGGWGDGFLNTTLFHGASGLNYGHNGATTVSFRAGGDWETVLSKVAEYKDRYAPFVTIQFGHNDQKPAANISLAEYTRNLEQFVSEARNAGATPILVTPLSRRNYETSNVTGEPTIILSLADQRAATIAAAKNSRAAYIDLNGASTRYLNRIGPDKAYMYNLNPEDRTHLNAEGSIVFGGMVAELIDGVFAGLKKAGYVRVDPRLKRALDQGVYYWPDSVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW13</accession>
    <name>B0XW13_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_033720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW13"/>
    <dbReference type="SMR" id="B0XW13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033720"/>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="PhylomeDB" id="B0XW13"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000019">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="13">
        <location>
            <begin position="26"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP55306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="520" mass="59342" checksum="2AABE8F13C451EC2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWG3</accession>
    <name>B0XWG3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_035820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035820"/>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="PhylomeDB" id="B0XWG3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="363" mass="40937" checksum="DE93196EDBEB416B" modified="2008-04-08" version="1">MEGLFFNVNNGYIEGIVRGYRNSLLTSQNYSNLTQCENIDDVKLQLAPAYGDFLAALPPNPSTSALAGKMTDKLVAEFRYLLAQATGSTAKFLQYLTYGYMIDNIALLITGTLHERDTRELLERCHPLGWFETLPVLCVATNIEELYNSVLIETPLADYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFHNFVNTHPDFKGTPTQEVMSELLQFEADRRAINITLNSFGTELSKQERRKLYPEFGKLYPEGSLMLSRADDLEGVSLAVSVNADYKAFFDAVGLSQGGGGGFGMGGGSDGKSLEDLFYQKEMELCKIVFTRQFTPAVVYAWMRLKEQEIRNVTWIAECIAQNQKERIGNFISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXI2</accession>
    <name>B0XXI2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_048420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048420"/>
    <dbReference type="HOGENOM" id="CLU_2263148_0_0_1"/>
    <dbReference type="OrthoDB" id="5428321at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="103" mass="11056" checksum="5DA5745E48705EE6" modified="2008-04-08" version="1">MRNALSGANNAGKPWQTISAVRLQPAPEDGYTWSVTDSKAHLMKTSLSSGTVGLYDAICREIGRSIEAVRPSREADGVLDSDRLTQGGNSCRRTSVKGTHLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXJ6</accession>
    <name>B0XXJ6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_048570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048570"/>
    <dbReference type="HOGENOM" id="CLU_1022987_0_0_1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="PhylomeDB" id="B0XXJ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="81"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="272" mass="30913" checksum="F52712B6B03DE1BF" modified="2008-04-08" version="1">MTSLYLFGYEIKHLIDREAPTLNNPNRETHEMCRNILRRLLACCTFFGFIAERSFVYIAHRFAIPLDLTAVPVIEDFLGRQDELDKLWQYLLPKRSQSRKVVILHGLGGIGKTQLAIRFARDHKHDFTAVFWLNGNDRSTLLHSLSSIFLRLPGQSQNIEAVNDEEVEQRGRYVSRWLTLRGNSWWLIIFDNINQYTPFSGAAGDANDIGEFFPGADHGSILITSRLQKLIELGRSFPVNKLGSDDAIELLLQSSHLSAGNTIRGTEKNPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXK9</accession>
    <name>B0XXK9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">saccharopepsin</fullName>
            <ecNumber evidence="12">3.4.23.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartic endopeptidase PEP2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Aspartic protease PEP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_037770</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar aspartic endopeptidase which is probably also secreted and contributes to virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.</text>
            <dbReference type="EC" id="3.4.23.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.25" evidence="12"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXK9"/>
    <dbReference type="SMR" id="B0XXK9"/>
    <dbReference type="MEROPS" id="A01.018"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037770"/>
    <dbReference type="HOGENOM" id="CLU_013253_3_4_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PhylomeDB" id="B0XXK9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760693" description="saccharopepsin" evidence="18">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="19">
        <location>
            <begin position="85"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="116"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP52611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="398" mass="43355" checksum="52741DFEDBEEAF3B" modified="2008-04-08" version="1">MKSTSLLTASVLLGSASAAVHKLKLNKVPLDEQLYTHNIDAHVRALGQKYMGIRPNVHQELLEENSLNDMSRHDVLVDNFLNAQYFSEISLGTPPQKFKVVLDTGSSNLWVPGSDCSSIACFLHNKYDSSASSTYKANGTEFAIKYGSGELSGFVSQDTLQIGDLKVVKQDFAEATNEPGLAFAFGRFDGILGLGYDTISVNKIVPPFYNMLDQGLLDEPVFAFYLGDTNKEGDNSEASFGGVDKNHYTGELTKIPLRRKAYWEVDFDAIALGDNVAELENTGIILDTGTSLIALPSTLADLLNKEIGAKKGFTGQYSIECDKRDSLPDLTFTLAGHNFTIGPYDYTLEVQGSCISSFMGMDFPEPVGPLAILGDAFLRKWYSVYDLGNNAVGLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXR1</accession>
    <name>B0XXR1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_038290</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXR1"/>
    <dbReference type="SMR" id="B0XXR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038290"/>
    <dbReference type="HOGENOM" id="CLU_016864_3_0_1"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="PhylomeDB" id="B0XXR1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="382"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="252"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP52663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="566" mass="61069" checksum="A506A6D018D15F25" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXS8</accession>
    <name>B0XXS8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_038430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038430"/>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="PhylomeDB" id="B0XXS8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="201" mass="22844" checksum="0DD9BA0FCE803FBA" modified="2008-04-08" version="1">MAAINKIAHNSPSRQNPSELETAIAGALYDLESNTQDLKATLRPLQFVSAREVEVGHGKKAVIIFVPVPLLQGFHKIQQRLTRELEKKFSDRHVLFVAQRRILPRPKRSVNSRTNQKQKRPRSRTLTAVHDAILNDLVYPVEIVGKRIRTKEDGSKTLKVILDEKERGGVDHRLDAYGEVYRRLTGRSVVFEFPQSGAAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXT1</accession>
    <name>B0XXT1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_038460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038460"/>
    <dbReference type="HOGENOM" id="CLU_101888_0_0_1"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="PhylomeDB" id="B0XXT1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="193" mass="20567" checksum="D7AEAF7F6485D460" modified="2008-04-08" version="1">MAQLNYRTINIDVLDPESSVNFPMETLLPATLPPPQTSSDAANVASQVRQLLRGGDPEGALRYVLDTAPLGGDDRAKEVHMATVVDVLQGIRQGEMTRVLEGVCSGEGGSERADCLMKYLYKGMAAPAPGGGAQSPRKSVSPQNTGFSQIQARNLGEGGSAQQMSVLLSWHEKLVELTGTGSIVRVMTDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXW4</accession>
    <name>B0XXW4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_038790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038790"/>
    <dbReference type="HOGENOM" id="CLU_005836_0_0_1"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="PhylomeDB" id="B0XXW4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="878" mass="99726" checksum="526CCFFB354AFAE7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY15</accession>
    <name>B0XY15_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_039300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039300"/>
    <dbReference type="HOGENOM" id="CLU_2589292_0_0_1"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="80" mass="8904" checksum="96C76C99ED7AB42A" modified="2008-04-08" version="1">MHQPEKKSPTAYHDWSSRGASTIVSNYKFSTPSILDPVDNLIDSETLNAKALKEKGIDTMVEEARKSTASESDADYLRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY18</accession>
    <name>B0XY18_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_039330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039330"/>
    <dbReference type="HOGENOM" id="CLU_031309_3_0_1"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="PhylomeDB" id="B0XY18"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="326"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="462" mass="51142" checksum="65B5570F1C88D114" modified="2008-04-08" version="1">MPRTSRQTRLPRGQVGIQSFARATKPSCSTLQDTKKPAAAQLPVSPSKKRKLNELENVDCATGEPRQTTIPEEAGTPSKTLRFSQLCVSTPRSGHYACSKTEASPAPAPPSSPSKRGGARVKRSNSLIVVERPACVEEFLSLHSAFLKALAIHSAHNGATTAADLREFLQAVERMWKKRKVVVKDLQRLIWAWEQGDEGNGPRYRLANYGLGKVCLERAPVNRERLDRFDEKELQDRFERVVDLLWEKAVDAADGDESQVDFFETLGVSPVHESLTPFTTFRKGQQRLQDLKGGVIKLKTEKLRADSQPETPAKPLDATTTRRKGLLERIKSKELLQSKLPPPPSKETLLRRAAAERAEEVVAVLALLRPVGYVGSGPKAVLAAQKKPFQLEMIVQNVQDSLRNPISSREVEMCVELLARPDIAGQWIEVVAVNQIKSVVLKSCASVYPKEIGAKVSKLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYC2</accession>
    <name>B0XYC2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_040390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040390"/>
    <dbReference type="HOGENOM" id="CLU_054787_0_0_1"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF33">
        <property type="entry name" value="SERINE_THREONINE KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="413" mass="43860" checksum="7C29535E216DD2F6" modified="2008-04-08" version="1">MAAPNMPIRLSVHTGTQDGKHPQLPKGSQPTPPITPTISHGRSSPGVDTPSRSISPVPFSGGQLHDAVPSDHQNVTAPHKFSDELEFHYDSKGRKLEFGRGVWSVVYMASSRAPSIPAALSPPSSPASGSRVVAVKMPGRRDAPPVLDAEALALTRLSMVAGCADHIVPFHGYIADSHAIVMGAVPLALSAYIEEKASAAKKHMSTSTMFDPVQGMAEWHGLAKKLVAGLDWLHNGARMVHGDIKPNNFLLRPRPIANDLDSDEFPFEPLFADFSSAHPIGDCTSATEGTALTALTPPFTAPELLSISALKSPDVVPTPASDVFSLAVTLLAAATGDLLLYPGTSSMQRLAMAREGHQVIDFARSSQSGTRIPRKGIVEQIVKPAIAKDPSQRIDPADWLGLVVNTSFPSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYJ9</accession>
    <name>B0XYJ9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_041179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041179"/>
    <dbReference type="HOGENOM" id="CLU_158082_0_0_1"/>
    <dbReference type="OrthoDB" id="5270965at2759"/>
    <dbReference type="PhylomeDB" id="B0XYJ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434:SF1">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434">
        <property type="entry name" value="CUPIN_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11827" checksum="75168FDDBE8BB2C5" modified="2008-04-08" version="1">MTQTYPIKSRRDDERLVREWGFKHVFTWTDGSNAYCPPHSHSGLTTHLIRRGTLTITYPDDNSKLHNGEVKKETFGVGARIDVPAGKLHEVWIGEDGCEYVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYL8</accession>
    <name>B0XYL8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_041360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYL8"/>
    <dbReference type="HOGENOM" id="CLU_079969_2_1_1"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="PhylomeDB" id="B0XYL8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="210" mass="23470" checksum="D3C172E30FB3D978" modified="2008-04-08" version="1">MDMETECTPGSRTNHSTISVTEQPSTFPSAWAALAPGHAPEPETVTDPVTDTPPDFPLDLNDWYQRYLSCMRFFLTESQHSPSVQALATFLNIRLPGDAADAATVSARVYIRRLVATGQDTPANLRLFFGEDWGAGVGAIRQQERLNYLFAAKSGGWAATKSAYDVLPDQQVPFLQPLREPEEAELRVADARWSEWLAMEDWMVGPRRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYS1</accession>
    <name>B0XYS1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol:UDP-GlcNAc transferase PIG-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_041880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041880"/>
    <dbReference type="HOGENOM" id="CLU_024002_1_0_1"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="PhylomeDB" id="B0XYS1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="508" mass="55263" checksum="AF5D5307A54ECCEC" modified="2008-04-08" version="1">MPPPPGSPPPIPPPVPVETHPNRTSSLKPPPEHRALPDPTRLAPEDAYFTSAHLRGRTANANYDDSLRALNGNTAALRPQPTYPGADSRKERKVRGPSRRRRRKGAWKKLLWVKQSYPDNYTDTETFLDHLQRNPRVRPYDFWPLVADSTVIVQHVCSVAIFVCCFVGIVQERVSPVSVVCWGSVGTAMGWILWDSWVWREHHAEQAPNAGRIADGDDGSSSSSAVSSVNPSSGATSRPVGPKDGQNEVHGLGLTISSGEPDGLLRRRSTGFSGEAYGPCEPGSPSHQASGGLSNMHLHHGSQETDETSLLSSRNRQRLSTVKSAFLIYFSLLGLSPILKSLTKSTASDSIWAMSCWLLIMNIFSFDYGSGEGAGATKFPASLSTNAAVMASTVLASRLPSTTHVFSLMLFSIEVFGLFPIFRRQLRHTSWTGHVLLTLALVIVAGGAVGMTLRGGWTAAVVGSFLGSIMTAFAMGGCSWWLISLQKYKNVVTGPWDPARPIIRRQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYY9</accession>
    <name>B0XYY9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_042560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042560"/>
    <dbReference type="HOGENOM" id="CLU_012317_0_0_1"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="901"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="949"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1087" mass="116002" checksum="9399EDB60DB91FBC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ57</accession>
    <name>B0XZ57_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serum paraoxonase/arylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_043230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043230"/>
    <dbReference type="HOGENOM" id="CLU_033924_0_0_1"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ57"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="305" mass="33711" checksum="1970855925A9138F" modified="2008-04-08" version="1">MKSTRLSFENFSGPFVTHGIDIIEDPENPNAVYIFAVNHLPNPEFTQDGKDVPQARSQVELFHHVLETATVKHVRSIQHPLIATPNDIYAESPNSFYVTNDHYYREGYGRLIEDLIPAAKWSSIVHVLIQDLKSKDADKGIDATVALTGLHNNNGLGHGRSKDEMLVVSCMSGTLYRARSNSDNRTISVFDEIHPGGQIDNPTYYADPYRTAADDASGYILAGMARPIDLSKHYNDPNAKDGAISGDQFTEWESSVLFEDDGTLIRTASTGLLVPSETKPGERKKAWLFVTGFVSESVIAVEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZH6</accession>
    <name>B0XZH6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_033900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033900"/>
    <dbReference type="HOGENOM" id="CLU_2060961_0_0_1"/>
    <dbReference type="OrthoDB" id="4233263at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="119" mass="14213" checksum="B0B9BB8B4D8D60C8" modified="2008-04-08" version="1">MSTPRIEHYTTDVHAHWEGIHPQDWAEVDLIGYENAMDKMYRTLCENPDAALVQVGHRSKLLNDHGSDYRFNGKFTSEQTKPERSHHDYNHFGKLMKWEGDRWYKYDFEVEVTDHTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZR6</accession>
    <name>B0XZR6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_044990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZR6"/>
    <dbReference type="HOGENOM" id="CLU_103863_1_0_1"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="97" mass="10817" checksum="C821A33C2464B9AC" modified="2008-04-08" version="1">MFHVVGNILQGMTYQKRDTKDPLLSASYVAHTKKKIGTTAAKDLNRFETECCNAVAPPGSQVTLSGKRKDLSKPLYRCNNWLDDVISLAFQKGIFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZZ8</accession>
    <name>B0XZZ8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_045100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045100"/>
    <dbReference type="HOGENOM" id="CLU_1351748_0_0_1"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="PhylomeDB" id="B0XZZ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23836" checksum="9C916B7211991151" modified="2008-04-08" version="1">MLKCIPGLAEFPNIQDPTHQENIMAAAVILRQYEEMEEETGEGRGRMEAEYDDDERVNFLAVTQRIIDSVIASPLDHSLATAAYWIVIRQEIYYALTRETVPHLRFDSDRWPNASIANNMIMFVGKVAQWRWGQKSLDEWTRLKLDEQKLIRESLGKMEPILELKADRAKGQIFPTVWYSFDVHATAAQHFQLAQMILTAENPQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0J1</accession>
    <name>B0Y0J1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_046390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046390"/>
    <dbReference type="HOGENOM" id="CLU_020492_2_0_1"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0J1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000279">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF222">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="569" mass="64271" checksum="999984D565C9F92A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y187</accession>
    <name>B0Y187_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_049060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y187"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049060"/>
    <dbReference type="HOGENOM" id="CLU_033907_2_0_1"/>
    <dbReference type="OrthoDB" id="3650366at2759"/>
    <dbReference type="PhylomeDB" id="B0Y187"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39546" checksum="24055F05BCF7A3FD" modified="2008-04-08" version="1">MADGNIAPSRSRLLLISVPRTASNLMLKLLNVPCQKLVTSERGGYFFFNAFLKVSGDGHRCVPIGERNEAEKREIRDAFQEAVDALEDCSERAEREAKIAFAKEHAFWFTNPAVLGNVTEDAASFRPRIPDKYGPSHTFSSLNHTVLPDEYLRTWRLTFIIRHPALAFPSLCRAMEKFRQSGFMQSVDTIGTQETNLTLKWTRMLYDWCLEQPDLPGKPLVLDAQDIIHNPQVMVRYCEETGLNPNALQFEWDNKPPSEAVETEAVRVKCPIPEKTDLDFDKAEAIMLSTLSASTGIIKDKTPTAVDVDAEVKQWKEEFGEEVATKLEMMVHDAMPDYEYLRSRRITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1B5</accession>
    <name>B0Y1B5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_059660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1B5"/>
    <dbReference type="SMR" id="B0Y1B5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059660"/>
    <dbReference type="HOGENOM" id="CLU_014603_1_0_1"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="412"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="513" mass="56750" checksum="32E0CDD75F6B7EA2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1F0</accession>
    <name>B0Y1F0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_060100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1F0"/>
    <dbReference type="SMR" id="B0Y1F0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060100"/>
    <dbReference type="HOGENOM" id="CLU_007884_7_0_1"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1F0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000028">
        <property type="entry name" value="Putative transferase caf17, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="7">
        <location>
            <begin position="291"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="447" mass="49111" checksum="807C0F6EFCA2492A" modified="2008-04-08" version="1">MRSITSSKRVCAHCLSRSRLFSTTVQHRAQPSSNAVPSSPPRSGYARLTNRGLISITGVDSTTFLQGLITQNMLIANDPRRATRRTGTYTAFLNSQGRVLNDAFIYPMPKGDSETDTTGDPAWLVEVDKNEVSSLLKHLKKHKLRSKLKLRALEDGERTVWSSWKDHAEPRWAAYNLESESSSPFAPSSSVAGCIDTRAPGFGSRLVTPGEEDLRVHLPDEAQVAGSQVDLGTYTVRRMLHGIAEGQAEIIRESALPLECNMDMMRGVDFRKGCYVGQELTIRTHHTGVVRKRIVPVQLYANSAPQSGDTPVYDPSAAVALPPSGSNISKVDGRKGRSAGKFLGGVGNIGLALCRLEIMTDIVLTGEGSHYSPEQEFKISWSAPEEGSSSATEPGEVKVKALVPPWLRDYISSGARNLARKVDNQEGHRAKELLYQLEEEEEQRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1Q9</accession>
    <name>B0Y1Q9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_060480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1Q9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060480"/>
    <dbReference type="HOGENOM" id="CLU_035836_0_0_1"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1Q9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1180:FF:000001">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="419" mass="47967" checksum="E62E0AC58C739A28" modified="2008-04-08" version="1">MAACERASRPLIQCIQKTCTRGLPGLQLQSTRTFQSTALAREEVQTETQSQPFYKNPDPALVTSPRLERKLLKQGVAPIGSRRRRAALQSSANIPFEQLPYQCFQEARKVLLADREEKIKKITAMREKIARLQAIPTEEAGGEQVQKSKLRAMELELERLKILADINDPIVKKKFEDGQGDMTKPIYRFLADRKWREYRRKILVQRITQMKVIPDVLPHCDPVVDTKLYFGRHTIQPGEFVNSRVSSTPPKLNIQLFEAGEKLVTIAVVDPDVPNVEKDGFDYKMHYLAVNVPISATSTKVDLANLSADSQVVLPWLPPVAQKGSPYHRLSIFIMEQKDSAPLNFSLVKGMETSRDVLLRTLQARYHLKAIGAHLFRTQWDENMLEVMREIGFPDADVELRRKRVEPLPYKRRNPSTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1X7</accession>
    <name>B0Y1X7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BZIP transcription factor JlbA/IDI-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_050190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1X7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050190"/>
    <dbReference type="HOGENOM" id="CLU_1214493_0_0_1"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF38">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="228" mass="24968" checksum="03467877AAB86F21" modified="2008-04-08" version="1">MSVTAISVQVARQTGPVFFQPQQRAYPTPAFCSPHFVFPDTTLDLASFAPDPSVSDTDPSAFVPLPPDLASFGDLDYASLPTGTSSSPYAPDSFDVTAISTPAVDVKDSLPCLDIDSSGTDSDTQINPGQIHTLTPPLLMPASRPQRVSISAASTAKDNPPKETPNRVLKRQLNTLAARRYRQRRVDRMNELEAELEKVKRERDELKMRVSKLEGETEALRGLLKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1Y4</accession>
    <name>B0Y1Y4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MYB DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_050260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2I2</accession>
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        <submittedName>
            <fullName evidence="2">Glucose repressible protein Grg1, putative</fullName>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="EDP52153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2J3</accession>
    <name>B0Y2J3_ASPFC</name>
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        <submittedName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
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                <person name="Venter J.C."/>
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                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
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                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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            <dbReference type="PubMed" id="18404212"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14310)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0521">NADP</keyword>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="335" mass="36956" checksum="7F688F9196F5B516" modified="2008-04-08" version="1">MQSVLQPVIGPRKEIHDLTGRVALVTGGALGIGYEISRAFVLNGARVIMVNRKEEQGQSAIDKIKEEAGADAKIEWIPCDMGDLNEIKEVFSGMRERESRLDLLILSAGINVNQYGETADGLDRHFEVNFLGQFYVVNQLWPLLRKTAKMPGTPPPRVVFESSEQHRNAPKVVHFGSVDEINNPEIGTTEVYGRTKLAIILGVRYGLLERVIKPNKDNIYVLSVHPGALTARQVNTAMQQQWKDAYPGLLGKLLTTAMLAVGRNVEQGSFSALYAATSPEIEEKGWNGYYFSDVAQPGKESAQASDPMLGAALWDLSHRLLKEKVGEDGLVDWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2N2</accession>
    <name>B0Y2N2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1115 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_062420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062420"/>
    <dbReference type="HOGENOM" id="CLU_064566_0_0_1"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2N2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="165"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="290" mass="32025" checksum="2724F462C281816D" modified="2008-04-08" version="1">MAQKELTLLPPDLMESQLSVIDLLTAMFPSPGEIDIPASTNECIEKLRNWCGKPSAVPSGIPSTLHLAVCLPIAGGEKSIQVNISIPVRWGAPDTAQPPPLSYSLRQPDWMSKAELATLAAAMPLDDVFEAFGYVQDEALRFLEAQRASESETTKTSSGPIVRVWFYFPSLSTREKRNDLVNHAPDYSLTGFVLAGKPGVLCLEGASTDIDAYMSFIKTHSWSDIPSHQKKVSERYRETNDVQRVFSGMEEITDSLGERSGHRANRGDMQALETWLQARGLHEAFAKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2U2</accession>
    <name>B0Y2U2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_051980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2U2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051980"/>
    <dbReference type="HOGENOM" id="CLU_037350_1_0_1"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2U2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.105:FF:000007">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase accessory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="30"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="484" mass="53043" checksum="A31D565DC673CB78" modified="2008-04-08" version="1">MSLLEASSQSPDEMVNFTLLSPATAPILAPRLGNLAIAGRKAIPTPNYIPLTSRGAVPHIAHDVMRDQTAIGSLFIGLEDFIERQAHTGPLRNGRPPIYNVPTAPHESALRKFISVPEDFLLILGPRRVPSIACPPNNTPNSISILTSVGFRQLEAGEYVEAVRKLRPDIVVGLADLAQGQTPGTKRRVKMADRTHAFTSHALEQLYGQTVPEGSRSKSAYFAPVLPLENTQQSLYLADLEHELRPHISGLALHESASLSILPEKLGNLPRLLFSDPATPHDILRQVSLGADIFTIPFLGATSDAGIALDFTFPAPSTVETIVSEPRPLAFDLWSTSFKVDTAPLNTSCECYTCKNHHRAYIHHLLSAKEMLAWTLLQIHNHHIMDKFFSAIRTSIERGTFLTDADMFHRFYAPELPEKTGEGPRLRGHQLPAAGPHQPRRFPRVYGRLDDAAEKFAESESSIATPDTGADGLEAHGFAQKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2W7</accession>
    <name>B0Y2W7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotide binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_052120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2W7"/>
    <dbReference type="SMR" id="B0Y2W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052120"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2W7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001300">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="316" mass="33579" checksum="0F1F929535AB903A" modified="2008-04-08" version="1">MPLDGVKNIVLVLSGKGGVGKSSVTLQLALALSLQGKSVGILDIDLTGPSIPRIVGLEDAKITQTPRGWLPVSVHPPENTAQDGAPPRGALRCMSLGFLLRDRGDAVIWRGPKKTAMIRQFLSDVSWGPTDYLLVDTPPGTSDEHIALAEQLLTLASTDPAVASSMGRPRLAGAVLVTTPQAVATSDVRKEANFCVKTQIPALGVIENMSGYTCPCCGEVSNLFSSGGGKVMAEELGIRFLGTVPVDVKFGELVEGKMVVDSDSDEEDGPTQAQQPEEPVDNRPLVERYKDCWSYSRFEEFAKTLISQIESGSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3C7</accession>
    <name>B0Y3C7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sexual development transcription factor SteA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_053740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3C7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053740"/>
    <dbReference type="HOGENOM" id="CLU_025505_0_0_1"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3C7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="688" mass="76669" checksum="4969209DC4FCB63F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3E9</accession>
    <name>B0Y3E9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_053960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3E9"/>
    <dbReference type="HOGENOM" id="CLU_003051_1_0_1"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3E9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000075">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="638"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="550"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="973" mass="107850" checksum="D2A865A3A46F9F22" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3M3</accession>
    <name>B0Y3M3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_054720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3M3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054720"/>
    <dbReference type="HOGENOM" id="CLU_055491_4_0_1"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3M3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="74"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="221" mass="24949" checksum="2052855E488B8045" modified="2008-04-08" version="1">MIQGCQNTLYNTRITPHDVVHHSNQFDKSNILQVNPIESYLHGSNVDNPYFYHQPRVQHRTTLQASHEMASDLITGSCACRHISYTASQPPSDVTNCHCTTCRKQAGAPYQSWATFAPGSLTWDKDKLPSVRRSSAFATRGFCPKCGSSVSMKYDYEPELLSVTTGTIDSAHQGKIPKPSCYLFLQEKVAWFDMPDDGVERWDRFSPDMAESLEKWQTMSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3V7</accession>
    <name>AMPP1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable Xaa-Pro aminopeptidase P</fullName>
            <shortName>AMPP</shortName>
            <shortName>Aminopeptidase P</shortName>
            <ecNumber>3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ampp</name>
        <name type="ORF">AFUB_055580</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3V7"/>
    <dbReference type="SMR" id="B0Y3V7"/>
    <dbReference type="MEROPS" id="M24.009"/>
    <dbReference type="EnsemblFungi" id="EDP51548">
        <property type="protein sequence ID" value="EDP51548"/>
        <property type="gene ID" value="AFUB_055580"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055580"/>
    <dbReference type="HOGENOM" id="CLU_011781_2_2_1"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3V7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000411779" description="Probable Xaa-Pro aminopeptidase P">
        <location>
            <begin position="1"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="654" mass="72680" checksum="8884D6BCE899397C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3X3</accession>
    <name>B0Y3X3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_055740</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3X3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055740"/>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3X3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="230"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP51564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="421" mass="46384" checksum="1CE303F1967871DC" modified="2008-04-08" version="1">MAGESWIGTCVHCTKLLASVPLSVLLAAISATLLGSFVLFYVVLYLVAPEPRKPLPEEKRYRTLSEDGAVTQPEQLPCWQDALDRQKRPGRIFDHSHMEKAELFMSLVVPAYNEEDRLAGMLEEAVNYLERMYGTLAASSASNEKAGDAVRQRKPTNGYANGHATTMVTPSGKVPPEKGWEIIIVSDGSKDKTEEVAFAFARDHQLSLHPKGYAGPWTPTPHEGVHIPPGTIRVVTLAENRGKGGAVTHGMRHVRGQYVVFADADGASNFEDLGKLVTACRDIEDSDGRGVAVGSRAHMVGSEAVVKRSKLRNFLMHSFHLILWLMTPPKTATIKDTQCGFKLFSRASLPYIIPYMHSEGWIFDVEMLMLAEFSNIPVAEVPVGWREVKGSKLNVVRDSIGMAWGLAVLRAAWTLGVYKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y412</accession>
    <name>B0Y412_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_056140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y412"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056140"/>
    <dbReference type="HOGENOM" id="CLU_028760_7_0_1"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="PhylomeDB" id="B0Y412"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000099">
        <property type="entry name" value="Homoserine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="144"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="532" mass="58492" checksum="A5BCFAAB6D264763" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y429</accession>
    <name>BTGC_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable glucan endo-1,3-beta-glucosidase btgC</fullName>
            <ecNumber>3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">btgC</name>
        <name type="ORF">AFUB_056310</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y429"/>
    <dbReference type="SMR" id="B0Y429"/>
    <dbReference type="GlyCosmos" id="B0Y429">
        <property type="glycosylation" value="5 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP51620">
        <property type="protein sequence ID" value="EDP51620"/>
        <property type="gene ID" value="AFUB_056310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056310"/>
    <dbReference type="HOGENOM" id="CLU_011476_0_1_1"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000395122" description="Probable glucan endo-1,3-beta-glucosidase btgC">
        <location>
            <begin position="1"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="3">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="3">
        <location>
            <begin position="329"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O22317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="688" mass="72692" checksum="D7B4BE06E954BF51" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4D9</accession>
    <name>B0Y4D9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_057450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057450"/>
    <dbReference type="HOGENOM" id="CLU_731539_0_0_1"/>
    <dbReference type="OrthoDB" id="4476058at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41283" checksum="7070EB309C910C40" modified="2008-04-08" version="1">MDKDLSVRISLRSGEFTPFPPQSLWALHCPPQRAQTGSILLCIRMQSTIVAALDVDADVFVDIWRRLKGLLGSSPENERTPQRESDHVDSVTERWRLLAQYQADIPRCSYDCSYTDFACICTRLEVISQDVSFMSCYNQCPLSPDQRWTPGRLLDFCDLVGVQPALPDYMSQYTELHRRQPVAERAFSWESGATGQVSALTVSDTATAIYASASDVEDFSTMTVGAIQTVFITKTATGFATSQTSSVSTYLPTATSEPVDPGLQSTSLSTGAKAGIGVAIPLAVIFIASILLWYIRRRKRNGGDSEEHGGAQLPTTVSPTSPVVNNLPFGKDGNAISELDGQQKLEADSNTKTPIFELDANMASPEKDSGEQKQVVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4S8</accession>
    <name>B0Y4S8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calponin homology domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_070160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4S8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070160"/>
    <dbReference type="HOGENOM" id="CLU_024074_0_0_1"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="621" mass="70408" checksum="B40D36C762E6E658" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y573</accession>
    <name>B0Y573_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_071620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y573"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071620"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="B0Y573"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="387" mass="44237" checksum="9493F14C0603AD9A" modified="2008-04-08" version="1">MPFPGLPLPPGILVDEEISPVYDSKHVEEPKSVVALKIVNNNASSADHEREVEEHISTADASHRGRSVVRTLLDSFEVKGPEGSHPCLVYPPMRESLSMYQRRFHDRQMPLPLIKTYIRALLTGLDYLHKICRTVHTDLKLENIMVSFEDPTVLADFMESQLAKPTAFKIDSAGRPVYQSRNDFGPLKSLRSIPQLVDFGLATRLEEDDDWGVWPIQPDHYRAPEVILGNGWQMPADIWNLGVLLWDMIEGKELFRHIHDQEGRYDARRHIAEMIALLGPPPPEVIQRYQYMREYSWPKPVRREDGRVCETAEEYFCGPFFDEKGRFLYKNLIPDRKLSDTASFLGGEEKETFLDLAKGMLVWHPDARKTAGELAGHPFLQPKPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y596</accession>
    <name>B0Y596_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_071850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y596"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071850"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="PhylomeDB" id="B0Y596"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="538" mass="57925" checksum="82ED0C0704036C60" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5A1</accession>
    <name>B0Y5A1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_071900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5A1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071900"/>
    <dbReference type="HOGENOM" id="CLU_008719_6_1_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5A1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="64623" checksum="EF7250F5F2ACF9BE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5R1</accession>
    <name>B0Y5R1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ornithine carbamoyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_064280</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5R1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064280"/>
    <dbReference type="HOGENOM" id="CLU_043846_3_0_1"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5R1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903269">
        <property type="term" value="C:ornithine carbamoyltransferase inhibitor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000017">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="16">
        <location>
            <begin position="46"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="15">
        <location>
            <begin position="205"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP50096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="371" mass="40143" checksum="F45AFD34554798A8" modified="2008-04-08" version="1">MACGLKLAAARFGALNGQHLRQRVSLNGLRQYSSQTTPPISPFAPRHFLSIADLTPTEFATLVRNASSYKRSIKSGSVPQNLLGALNGKTVAMMFSKRSTRTRISTEGAVVRMGGHPMFLGKDDIQLGVNESLYDTAVVVSSMVSCIVARVGQHAEVADLAKHSTVPVINALCDSFHPLQAIADFQTMHEMFTPKAHGLSSLGLEGLKIAWVGDANNVLFDMAIAAAKMGIDLAVATPKGYEIPAHMLEIIEKAGEGVSSPGKLIQTNVPEEAVKGADVLVTDTWVSMGQEAESIKRLKDFEGFQITADLAKRGGAKEGWKFMHCLPRHPEEVNDEVFYSQRSLVFPEAENRLWAAISAIEAFVVNKGKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Y9</accession>
    <name>B0Y5Y9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_065060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Y9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065060"/>
    <dbReference type="HOGENOM" id="CLU_061428_0_0_1"/>
    <dbReference type="OrthoDB" id="4779287at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF7">
        <property type="entry name" value="MEMBRANE ANCHOR OPY2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="243" mass="25377" checksum="87019CC941167D3F" modified="2008-04-08" version="1">MSGVLDGPAGFALRKNGTCLDTEVDCGATMPPFRACCPAGSQCPSQYNVNCCPSAANCTQLLLETPKCANETWNLYNYYGYFCCENGTTAFGTSSNSDGCAVPGYQFDSSETLLPVVSLGKASFGTSTASVTSTLSTSSTSAASPTQTSTQPPDTSSKTNTGAIAGGVVGGVAGVALIAFLVWWLVSRRTKRQPAVSGPQVVPITDYKDNSQMVSELDGHSTVHELEGQENPHELPADSAFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y651</accession>
    <name>B0Y651_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_065680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y651"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065680"/>
    <dbReference type="HOGENOM" id="CLU_041799_0_0_1"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="PhylomeDB" id="B0Y651"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EVE" evidence="8">
        <location>
            <begin position="116"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="277" mass="31186" checksum="F6DB57DAB506D48D" modified="2008-04-08" version="1">MGRKRKSEGAADSNPPKRPAIDPYTGEPRKRGRPRKYPPGQEPPPPPGPKRGRGRPRKDGTIRSPNSAPETPQGPKRPVGRPRKNPVQNGTETPSRPILSESEEPKIDDEESDRSYWLMKAEPESRMEKGVDVKFSIDDLQAAEKPEPWDARNHIRAMKKGDYAFFYHSNCKVPGVVGMMEIVQEHTPDESAFDPAHPYYDPKSKRDNPKWEVVHVEFRRKFKKMVTLNDLKAHATPGGPLEDLQVLKQTRLSVSSVTPAQWKFILGLAGESSESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6R9</accession>
    <name>B0Y6R9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide riboside kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_067920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067920"/>
    <dbReference type="HOGENOM" id="CLU_058668_1_0_1"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6R9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37749" checksum="515F356223F8B1A9" modified="2008-04-08" version="1">MTMAEAEAETTTGSKNPITIVGISGPSSSGKTTLARLLQRIFAHANENMQTFIMHEDDFYLPDDRIPYTTTASGKTVQDWDTVEAIDVPFMVAALSYIRQHGRLPPRLKSKEDLNEASDSGVSDETITQLQRQVSDKLRQFGPALAGDGGEGKRTVVFFEGFLLFSPPEAEVREHVLRPVHEQLDVRLFLPSPYESVKERRERRSGYVTIGPAPVPPLPHRDSAASKDAKQQVDLEAEDNAPPQNFWTDPPGYVDDIVWPRYVRDHAWLLLPESGLDNDRYQSTRNSDTDELIRIVGQGTNVRTDAGVAVAPGKGTLPMVDVLKWAIQEVMKPLEMAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Y6</accession>
    <name>B0Y6Y6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 69</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_068580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068580"/>
    <dbReference type="HOGENOM" id="CLU_045137_0_0_1"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6Y6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34016" checksum="ED9D0F0B8FE8FD1F" modified="2008-04-08" version="1">MLYRNSVARSVLRAISSSNASVARSTLSNNVFKAHLTSSARFPARASSLALTTRKPVTTALVRYASSVPGSTNVPKEAKVAEEDHDMMAGIKTEAKVIKDTFSLEGTPKEALYLGMAGVIPYLATSLETVYLSYEINRATATGDGLIFSGQTAELMLHMLEPIQVGYGAVILSFLGAIHWGLEWAGYGGKHGYKRYAAGVIAPAVAWPTLLLPVEYALISQFLAFTFLYYNDARAAAHGRAPHWYGMYRFVLTFVVGASIVASLIGREQIANTISTEHTITDKINALLFLQKKEKEEADARRRAELGEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y710</accession>
    <name>B0Y710_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_068820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y710"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068820"/>
    <dbReference type="HOGENOM" id="CLU_037460_1_2_1"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="PhylomeDB" id="B0Y710"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="407" mass="44787" checksum="679277C1CED1C5C4" modified="2008-04-08" version="1">MATTPVSVVCVGMAGSGKTTFMQRINAYLHSKKKIPYVLNLDPAVYSVPFESNIDIRDSINYKEVMKQYNLGPNGGILTSLNLFATKVDQIISLLEKRTAPNPENPSAKPIEHILVDTPGQIEVFVWSASGSILLETLASSFPTVIAYVIDTPRTTSTSTFMSNMLYACSILYKTKLPMILVFNKTDVQDAEFAKEWMTDFDAFQQALRDEEESGAFGGEGSTAGFGAGSGYMGSLLNSMSLMLEEFYRHLSVVGVSSMTGDGIDEFFQAVEEKRQEFERDYKPELERKKKEREETKAAQRELELGKLMKDMSVSGSSRKPRPANEAETVSEAEEEEEEAAAAASKGDLEFSENDDDTDDDEGGVPPAGDEAGLSQRYKEALSESQGGPNDADLSFARYLRSSNINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7S1</accession>
    <name>B0Y7S1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_074790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7S1"/>
    <dbReference type="SMR" id="B0Y7S1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074790"/>
    <dbReference type="HOGENOM" id="CLU_029393_1_2_1"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7S1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="11">
        <location>
            <begin position="95"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP49452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="446" mass="50474" checksum="A4FD8B290F39C55E" modified="2008-04-08" version="1">MSLKFMARLPRPARSQRTLLPSVKRWGSSISQRPGSDRVRFPGAVNSKFTTEMSFINPAETSSIPTYRVMNSDGVMLEKDRKSLDVSNEEILTWYKNMLTVSVMDVIMFEAQRQGRLSFYMVSAGEEGISVGSAAALTPDDVVFAQYREAGVFQQRGFTLRDFMSQLFANRNDNGRGRNMPVHYGSNYPRTHTISSPLATQIPQASGAAYALKLQALQNPDTPPRIVACYFGEGAASEGDFHAGLNIAATRSCPVVFICRNNGYAISTPTLEQYRGDGIASRGVGYGIDTIRVDGNDIFAVYEAMREARRIALTDGGRPVLIEAMSYRVSHHSTSDDSFAYRARVEVEDWKRRDNPIIRLRKWLENEGLWNEDMEQETRDQLRKAVLKEFGDAEREKKPPIRAAFEDVYDELTEEAQEQMKELKRILETYPEEYDLRQYEDGIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8V8</accession>
    <name>B0Y8V8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">40S ribosomal protein S29, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_078720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8V8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078720"/>
    <dbReference type="HOGENOM" id="CLU_177289_1_0_1"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8V8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_uS14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_uS14_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="78" mass="9154" checksum="39A0180D0E9F53F2" modified="2008-04-08" version="1">MTHESVWYSRPRKFGKGSRECRVCAHRAGLIRKYGMDICRQCFREKAQDIGFYKVVPLNLFSRSISCFTTNRYVLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8W3</accession>
    <name>B0Y8W3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory particle subunit (RpnI), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_078770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8W3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078770"/>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8W3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="199"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="405" mass="46040" checksum="551920D79EA32758" modified="2008-04-08" version="1">MSSLHYGGAETPPKLLPSLLHFSTMENQKISDFLADQLQQAPEQSQAFFLSFEDFWERKLWHQLTNALVEFFQLPESAPQRLPIFKTFVLSFADKINQLKFVSLGLMASTECADDQERLSFLTSLADKVNKPDTQEAYVYALAEVANVKQRLQDLDGAQKDLEVCQKVLDSFDSVETVVHASFYKVNADYYHAKQEFAAYYKNALLYLACINLDDLSESERVSRAYSLSVAALVSDTIYNFGELLLHPILDSLTETPHSWLRDLLFAFNRGDLTAYDVLAGNISKNKLLEQHRIFLYQKISLSALTEMVFRRPPHDRNLTFASISSETKVKPEEIEHLVMKALSLGLLKGAIDQVAQVAQIHWVQPKVLDMKQIEGMRNRLKDWDAGVNQLGHWIEGVGKDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9R5</accession>
    <name>B0Y9R5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_082010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9R5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082010"/>
    <dbReference type="HOGENOM" id="CLU_041579_1_0_1"/>
    <dbReference type="OrthoDB" id="5337545at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="367" mass="39064" checksum="2BC30F5C496A7EFC" modified="2008-04-08" version="1">MSNNSAKRGTGEKSPNDPRKQADSRKSDPESQNSPSLANRIQNSAAGLAWSAFNAAGSSADAAQVLGSGSKAGPSSSASSSALAAAEQYRETATPTSSNRVLANHPAASFRSSSAGQQGAFELPPLTEDEFQCTYDESQVHDRIDFPPSTETETDTEKGKGKASEALSAFSNIEPSSSSSGLNTTWQNTLPTTATPLPSDGEAVVSLLSDASFDPEFPSTAEEPFEPVETELLPPQLTPSEIQMIESFRRHAALETSTPTPATEPLSLTHRLTSLSLVPDIQSVLDSVPAAQATDATALRDAVLKGLPGVAEWIAVEERYHDEVWGYLRPTLEAAAKEMEERKEQGAPVEDGPAVRRLKMILRHMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAZ1</accession>
    <name>B0YAZ1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Fumitremorgin C synthase</fullName>
            <ecNumber evidence="15">1.14.19.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Fumitremorgin biosynthesis protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_086320</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tryprostatin A + reduced [NADPH--hemoprotein reductase] + O2 = fumitremorgin C + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35963"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:72761"/>
            <dbReference type="ChEBI" id="CHEBI:72763"/>
            <dbReference type="EC" id="1.14.19.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.71" evidence="15"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAZ1"/>
    <dbReference type="SMR" id="B0YAZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086320"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0YAZ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000160">
        <property type="entry name" value="Fumitremorgin C synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0349">Heme</keyword>
    <keyword evidence="10 18" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP49184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="58983" checksum="A9D616753BDA4B46" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB04</accession>
    <name>B0YB04_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080030"/>
    <dbReference type="HOGENOM" id="CLU_062854_0_0_1"/>
    <dbReference type="OrthoDB" id="4367202at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="261" mass="28926" checksum="51270995D77FB32D" modified="2008-04-08" version="1">MKVTATRELFYRKQTIANLRAVFRKDVEVLTCQFGSRTVALACTLEADGGRTEVMQSSSLELTNALRDLHNLSSNCVRTYFADHDYQISKDELAACSIDLPRTPGLSIKPNQSTNLKDESLPNGEAVTEGSADMSAEASPHGCMTEVNSLPVRSQEQSHADKKGFPSLVQILWPPFYNTPIAETRDIAVASRQAILQVATTILAENGLSDTNFPMESLCVGHGDSWYDMLNYEDDDIRDLLDGILLSEKVLRIKCVYAMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBH2</accession>
    <name>B0YBH2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_092800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBH2"/>
    <dbReference type="SMR" id="B0YBH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092800"/>
    <dbReference type="HOGENOM" id="CLU_437407_0_0_1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="PhylomeDB" id="B0YBH2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF402">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="101"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP48562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="625" mass="69149" checksum="728BF47C65B215A0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBZ5</accession>
    <name>B0YBZ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_088360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088360"/>
    <dbReference type="HOGENOM" id="CLU_1864676_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="137" mass="14462" checksum="C93D07A7892BAE49" modified="2008-04-08" version="1">MEYTAVMLKFGLGIGDRSKNARHRCEGPQLNSVKNATSFLTVHEVNQNQYTNQKEPSSIVTILLPLSSNACQSILRAIAHAVCRLSQSLSGTRDSVSKSLGGSADGVSESFGRATNSLSKATNSVTDSVCEATNGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC46</accession>
    <name>B0YC46_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_088870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088870"/>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="PhylomeDB" id="B0YC46"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="81"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP48177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="217" mass="23621" checksum="357F4627D368C55D" modified="2008-04-08" version="1">MSQSNLSQSTQTPDAAATQVAGHPSSHPSRTTELSGLKVRLRAALRQFPDFPSPGILFEDILPIFADPTLHEALLRCLELHILETHGNQKPDVIVGLEARGFLFGPSLALRLGASFVPVRKKGKLPGPCETQGYEKEYGQDFFQMQADAIKPGQKVIVVDDIIATGGSAYAAGELIRKMGGELMGFIFILELEFLNGRDKLPAPVYTLLSGQESKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC85</accession>
    <name>B0YC85_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_089290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000893_1_0_1"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="PhylomeDB" id="B0YC85"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="1489"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1475"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1804" mass="201383" checksum="2338F01EA4E15DEB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC88</accession>
    <name>B0YC88_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_089330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089330"/>
    <dbReference type="HOGENOM" id="CLU_002728_0_0_1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="PhylomeDB" id="B0YC88"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="629"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="810"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="739"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1054"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122236" checksum="3424D26C59FAF8B9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCK9</accession>
    <name>B0YCK9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_090560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090560"/>
    <dbReference type="HOGENOM" id="CLU_022341_1_0_1"/>
    <dbReference type="OrthoDB" id="3759773at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="645" mass="73165" checksum="F138B15E6E7172F0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCS3</accession>
    <name>B0YCS3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_093010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCS3"/>
    <dbReference type="HOGENOM" id="CLU_031977_1_1_1"/>
    <dbReference type="OrthoDB" id="5414547at2759"/>
    <dbReference type="PhylomeDB" id="B0YCS3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="195" mass="21919" checksum="319D6C1C1281B25E" modified="2008-04-08" version="1">MDVKEIIALHSLLHLVFHRNKNQHGNTKWWKWLSILKRITLKLAKSLETDAFHTVRLYKEHLALHVIPNCYLAFSRVIADGQFSTIGIVLIAALARLTKATGIDKEMNSLHGKKMAFRPSTCLKNLQQEDVGEVVSRLSESFIPLPSFQSGKQAGSEEPNSHQREAKETATVAVKPSGQKKRKKNAIDDLFNGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEC8</accession>
    <name>B0YEC8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_098730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098730"/>
    <dbReference type="HOGENOM" id="CLU_059988_2_0_1"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="PhylomeDB" id="B0YEC8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="56"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="286" mass="31285" checksum="F69A96A133507A9D" modified="2008-04-08" version="1">MTPTEQQEQEQPSPTSTTIMPASPSRTGTLLANLSSVTSRISTAALNANRPATKPIRLIAVSKLKPAADILALHNPPTNHLHFGENYLQELLEKSKLLPPSIRWHFIGGLQSNKCVTLARDVRGLWAVESVDSEKKASLLDRGWGERSEEVRGVALEDRLRVFVQVNTSGEENKAGVDPVAGAVPLARFIREKCPRLKLQGVMTIGAIARSKATTPETENEDFVCLRETRDRIVRELGLQGDDAELELSMGMSEDFEGAIKLGSDEVRVGTTIFGERPPKSEAKVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEH1</accession>
    <name>EIF3C_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="1">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="1">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nip1</name>
        <name type="ORF">AFUB_099160</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEH1"/>
    <dbReference type="SMR" id="B0YEH1"/>
    <dbReference type="EnsemblFungi" id="EDP47315">
        <property type="protein sequence ID" value="EDP47315"/>
        <property type="gene ID" value="AFUB_099160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099160"/>
    <dbReference type="HOGENOM" id="CLU_004304_0_2_1"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="PhylomeDB" id="B0YEH1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000364274" description="Eukaryotic translation initiation factor 3 subunit C">
        <location>
            <begin position="1"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="600"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="813"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="818"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="862" mass="97509" checksum="C8C9160DD0D026ED" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF05</accession>
    <name>B0YF05_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_101130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101130"/>
    <dbReference type="HOGENOM" id="CLU_038077_0_0_1"/>
    <dbReference type="OrthoDB" id="3021074at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760971" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40154" checksum="5A708360F8ACECFE" modified="2008-04-08" version="1">MLTSAILVPWLLTAVPASSASSLLRYDATLDKGRIECVYPISGQYALLHRVLYYSLLLFSIVSGKTPWLVAGALGAAMTYAGSAAVHATILAGISRDSLLDLDCLGIFAIVSVGSLVVTVFFHGGLLMVVGTICAIVAMLRDYPSEDQCTSIPSDATNSTEPILLTSAAQSGLVPFNCTYACFSTRQAFRDPGDIRVVPAGTVSTQRFRLLEVSIWLSRFLGAVVSLYRLLRRHAKQMRSMAQKKLAHEQKRGRPGLMTDLLLIACVVVIVLNEVFIHLSDGIPTSEPPNAVGQWGPWVAVIMALAGSAIVEYHRPAWEEWQRVLREEGVLVEAEKNPSLVPSLWMRLSNMGGKSPATESGPSRSSLAKGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMA4</accession>
    <name>B0XMA4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-like ligand binding domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_000380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000380"/>
    <dbReference type="HOGENOM" id="CLU_090569_0_0_1"/>
    <dbReference type="OrthoDB" id="1161823at2759"/>
    <dbReference type="PhylomeDB" id="B0XMA4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="98"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="213" mass="23709" checksum="3850D2DEEDD6837F" modified="2008-04-08" version="1">MHRGLSLLWRHFGIIRATRSGLNPVPIASTIYCKKYPHQAFHHNVGKMSSFDKFNGNTADEPPKNEMVYLPGVMSPNRKFGVFRKVLHTGLYSQLVAMEVPVKGEIGDEIHTVDQTLIFTHGRGKAIVAGKEQEIKEGDVVIVPAGTQHQFLNIGDVPLEVVTIYAPAEHYPSTMHQTKAEGDAQEERGEDEAPEWSQRSKAENEKLGLVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMA6</accession>
    <name>B0XMA6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_000450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000450"/>
    <dbReference type="HOGENOM" id="CLU_025883_0_0_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="PhylomeDB" id="B0XMA6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="508" mass="58054" checksum="3A5E8FB8DFE86171" modified="2008-04-08" version="1">MDDHNKAVATIAGQVRKFHSRRQPFRIYHGSTNSTRQSQHHHNNTVNTAHLNHVIRTDCEAQTVLVEPNVPMDHLVRATLAAGLVPLVVMEFPGITAGGGFSGTSGESSSFRHGFFDATVNWIEIVLPNGEVRIASKSSDPDLFWGAASAFGTLGVVTLLEVQCQQAKPYVELKYESASCMTHAMDIFRAAAADPQIDYLDGIVFARDHIVVCTGRLIDSLPANVRPQRFTGARDPWFYLHAQKRANTSSRKPDYIPLTDYLFRYDRGGFWVARYAYSYFLVPFNRITRYILDYFMHTRVMYHALHESGHSKRYIIQDVAVPYAATTEFLDWLDQKQNFGAYPIWLCPLRRSEGLMSSADSKNPVPPSTDPEDDGYLMNFGLWAPSPFHSNPDQFIAQNRRLEGKVRELGGKKWLYAHAYYTEDEFWSLYDKRKYDQLRERYHASYLPDLYQKVRVRLAAPEDGNGCKGWGYIRDIVWNLWPVSGLYGVYKAWRGGEYLLKAKEESTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMP2</accession>
    <name>B0XMP2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear segregation protein (Bfr1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_013660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013660"/>
    <dbReference type="HOGENOM" id="CLU_023943_1_0_1"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="PhylomeDB" id="B0XMP2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="510" mass="57453" checksum="B780514B48764029" modified="2008-04-08" version="1">MAAAANAAPAMEQKARPTKPNEEAFKADLAQAEKEHAAVQEKLNQIKAKIESAKPNNQDSPSAKRQQELRAELSSIRQKQQGFKASRTSTQEKINALELTLKARITEQNNSRTRMPFKNVEDIDREIARLEKQVDSGTLRLVDERKALSDISTLRKQRKNFAGLDEQQKVINDLKAQIATLKKTLDNPEAKALSDKYTEIQKELDAIKAEHDSAFKNLNALRDERTKLHAEQQKKWNAIREIKDNYYKARKAYKEYEDEAWRIRREKQKAQREAFEREKKKKIADKKLEEASRPAYTDEILIAQGLIRHFNPSYDFSTLGLDDKKDQSSAFRAQVGRTVDDSNIKGMKVLKKEDREEDYFVGTGGKKSKKGKKGTANGSPAPGTPAEPTKFNLNVGVIEDFAKVKIDPPMNQSDVPAVIEKLAAKITEWKANQAAKTQENIKKAQEEIKRLEEEEANSDSQRATDHAKKVAIENSGVNGKVSAEAELKQENDAAADVSEELQKASIEDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMV4</accession>
    <name>B0XMV4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD superfamily hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_003430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003430"/>
    <dbReference type="HOGENOM" id="CLU_036524_0_1_1"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="PhylomeDB" id="B0XMV4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="243" mass="27229" checksum="CC98A67AAA8A5861" modified="2008-04-08" version="1">MAPPTELHHLYTTMAAFVTSCMSAHDPSHNPAHVHRVVTLARTILEKEQLLHPDITYDEDVVKLAALLHDIGDRKYLTQVAAATSAAGEQQQQQAAVDPGRMVEQALLAHGADVALAARVQTIVTHVSYSKEVKDPATVRRLIDEEGYVELAVVQDADRLDALGAVGIGRCFTFLGAQGRKYLSPEEPWDMNNAIAHFQDKLERLEGMMKTQTGREMARVRTQRLIEFRKWWEEEMEEATHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMZ7</accession>
    <name>B0XMZ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain-like protease PalBory</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_003860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMZ7"/>
    <dbReference type="MEROPS" id="C02.008"/>
    <dbReference type="HOGENOM" id="CLU_006770_1_0_1"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="PhylomeDB" id="B0XMZ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="75"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="805" mass="89870" checksum="83518B5624807421" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNI1</accession>
    <name>B0XNI1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_015230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNI1"/>
    <dbReference type="HOGENOM" id="CLU_016094_0_0_1"/>
    <dbReference type="OrthoDB" id="5422351at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF1">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE GLYCOGEN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="596" mass="65403" checksum="1792884376F75C1D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNI3</accession>
    <name>B0XNI3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_015250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015250"/>
    <dbReference type="HOGENOM" id="CLU_008296_1_0_1"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="PhylomeDB" id="B0XNI3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061676">
        <property type="term" value="F:importin-alpha family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046822">
        <property type="term" value="P:regulation of nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="872" mass="96310" checksum="F8FA64DB9C2DEF49" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNP8</accession>
    <name>B0XNP8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanyl-nucleotide exchange factor RasGEF, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_005040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNP8"/>
    <dbReference type="HOGENOM" id="CLU_005431_1_0_1"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="PhylomeDB" id="B0XNP8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="379"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="629"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="882" mass="98908" checksum="54F200900F6022BB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP51</accession>
    <name>B0XP51_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_005940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005940"/>
    <dbReference type="HOGENOM" id="CLU_005027_4_1_1"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="PhylomeDB" id="B0XP51"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF104">
        <property type="entry name" value="PROTEIN CAP1, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05595)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="309"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="607" mass="70015" checksum="EC30D5105B36DFD7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPS5</accession>
    <name>B0XPS5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_007410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007410"/>
    <dbReference type="HOGENOM" id="CLU_036517_0_3_1"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="PhylomeDB" id="B0XPS5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="38596" checksum="BBA16108ED7411D6" modified="2008-04-08" version="1">MAPVPATILRALSLPAASKANLSTANLGSGFTSTGVIRATVPTADGTGEEERQYFVKTSANGQAAEEMFRGEYESLNAIADSVPGFCPRALAWGPLDAQDSKDKSKSFFLATEFLELGAGAGGRNRRTGESLAQRLGKLHSTPAPADPETGRRRFGFPVPTFCGDTKQPNRWRDSWAEFYAQERLLTVLETSEKRNGKDVGLREMVERTVRSVVPALLRDGHLGYDREGKGEGITPVVVHGDLWSGNADLGRIVSSGRKEDEEVGAVVYDPSACYAHSEYELGIMKMFGGFGPAFFEAYHRIVPKTEPVEEYEDRVRLYELYHHLNHHAIFGAGYRSGAVSIMQKLLKKYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPS9</accession>
    <name>B0XPS9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_007450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007450"/>
    <dbReference type="HOGENOM" id="CLU_003635_0_0_1"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="PhylomeDB" id="B0XPS9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000817">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="7">
        <location>
            <begin position="515"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1363"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1001"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1370"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1526" mass="164400" checksum="27C786C574BD776B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ01</accession>
    <name>B0XQ01_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 phenylacetate hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_008160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008160"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ01"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="516" mass="58124" checksum="7DD9E7AA4B5FC6D5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQB5</accession>
    <name>B0XQB5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_009370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQB5"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="B0XQB5"/>
    <dbReference type="Proteomes" id="UP000001699">
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:aldose reductase (NADPH) activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:alcohol metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:arabinose catabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:ketone metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="11">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="298" mass="33493" checksum="777023DA7215B6CB" modified="2008-04-08" version="1">MSTLQHTKKTYTLNTGDKIPAIGLGTWQSKPNEVREAVKAALLKGYRHIDTALAYGNEAEVGQGIRDSGIPREEIWITTKLDNTWHHRVQEGIDSSLKSLGVEYVDLYLMHWPCSTDPNDKSKHLPDWDFIKTWQEMQKLPATGKVRNIGVSNFGIRNLEKLLNDPSTKIVPAVNQIELHPNNPSPKLVAYNTSKGIHSTGYSCLGSTNSPLYKDQTLLQIAEKKGKTPQQVLLQWGLQKGWSVIPKSVSEERIGKNFELDGWDLTADEVNQLDNLKGRFKVCGDSWLPVKVFFGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQI8</accession>
    <name>B0XQI8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_010110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010110"/>
    <dbReference type="HOGENOM" id="CLU_013114_0_0_1"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="PhylomeDB" id="B0XQI8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="763"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="338"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="775"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="878" mass="97441" checksum="96075F9720F0C6C8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR68</accession>
    <name>B0XR68_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Nitrate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">AFUB_012300</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="19">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012300"/>
    <dbReference type="HOGENOM" id="CLU_003827_4_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="PhylomeDB" id="B0XR68"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000001">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000016">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000049">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 19" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="14 18" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="515"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="617"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EDP56519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="869" mass="97614" checksum="194FE0AFD976755E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS08</accession>
    <name>B0XS08_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_025510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025510"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="PhylomeDB" id="B0XS08"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="88"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="468" mass="51082" checksum="59E8CF3FD6043F7E" modified="2008-04-08" version="1">MSSPRLPTPTTTTTTTTTTTTASTSSSSFSSFSSSSSSSVARNRLASISSQIMGSSSPSVFSTAVVPAAPEDPLFGLAQAFRQDPSDKKVDLVIGAYRDNNAKPWILPVVKKADEAIRNDPNLNHEYLPIKGLPDFTSAAQKLIVGADSAAIREKRVCTLQAISGTGALHLGALFLAKFHPVPPKVYLSSPTWANHHQIFTNVGLKLANYPYFSAKTKGLDFDGMLGALREAPPGSIIVLHACAHNPTGVDLTQDQWKQVAVVLRERQHFPFFDTAYQGFASGDLSRDSWAIRYFVDQGFELCIAQSFAKNFGLYGQRTGAFHFVSAPGPDASTANANIASQLAILQRSEISNPPAYGARIASRILNDPQLFAEWEEDLRTMSGRIAEMRKGLRERLEAKGTPGNWEHITSQIGMFSFTGLTEEQVKILREKWHVYMTKNGRISMAGLNTHNLDYFAEAVDSVVRETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSA6</accession>
    <name>B0XSA6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_026510</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026510"/>
    <dbReference type="HOGENOM" id="CLU_001718_1_0_1"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="PhylomeDB" id="B0XSA6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3200.20:FF:000002">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="472"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="783"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1267"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="172"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP54592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1462" mass="166057" checksum="7006827C5F49D30E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSH6</accession>
    <name>B0XSH6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_027220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027220"/>
    <dbReference type="HOGENOM" id="CLU_059017_0_0_1"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="PhylomeDB" id="B0XSH6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="305" mass="33563" checksum="DED01CE92FAFC26C" modified="2008-04-08" version="1">MDKFQAFGKNLSASFTPFAARTQQLIKEQLGQAEDKTQLPDEYIELEKRVDALKLVHQKLLQVTSQYSNEAYDYPPNIRESFNDLGRTISEKVQLLSQASSPAEAQAALVAPPSAKPQPKTFNHAIARASLAGSQTLAQVHPGEDPLATALEKYALASEKVGEARLAQDAQIQSRFLAGWNTTLNTNLMFAAKARKNVENARLMLDSIKARRKAAAGGDLDNLSEEARAEIEQAEDEFVGQTEEAVSVMKNVLDTPEPLRNLADLIAAQLEFHKRAYEILSELAPVVDGLQVEQEASYRKSREGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSH8</accession>
    <name>NAGS_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber>2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Arginine-requiring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>N-acetylglutamate synthase</fullName>
            <shortName>AGS</shortName>
            <shortName>NAGS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">arg2</name>
        <name type="ORF">AFUB_027240</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSH8"/>
    <dbReference type="SMR" id="B0XSH8"/>
    <dbReference type="EnsemblFungi" id="EDP54664">
        <property type="protein sequence ID" value="EDP54664"/>
        <property type="gene ID" value="AFUB_027240"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027240"/>
    <dbReference type="HOGENOM" id="CLU_013088_0_0_1"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="PhylomeDB" id="B0XSH8"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000049">
        <property type="entry name" value="Amino-acid acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000372550" description="Amino-acid acetyltransferase, mitochondrial">
        <location>
            <begin position="45"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="537"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="716" mass="78710" checksum="BAA6D761975755A0" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSL5</accession>
    <name>B0XSL5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_027620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027620"/>
    <dbReference type="HOGENOM" id="CLU_101842_0_0_1"/>
    <dbReference type="OrthoDB" id="4171340at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="241" mass="26797" checksum="A97EEEF9142B75D3" modified="2008-04-08" version="1">MFNPNIPNTGYRGRPIVIEDDNEDNGGMQVDYAPAQHPQHSFMAYGHNASSARMPSPGYPAWHTTHEQEKKVRSRLREERHAALCVLLDRELLTLQALATQETLPQARRRFLSKLLAPGDPEEAAKIRADRFIIQHPSTTASSSSSSSVPLTVSRGLVDVHETDDGGWRRPDAGSGPGSAVSSPASGSKKRGKETPDRARSKVKVSVSRQQQQQRERERRRRWSGAERDEPGSPSMQRFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSN1</accession>
    <name>B0XSN1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_027770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSN1"/>
    <dbReference type="HOGENOM" id="CLU_013866_6_2_1"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="PhylomeDB" id="B0XSN1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="492" mass="54265" checksum="2E4A8F0644FBB5E5" modified="2008-04-08" version="1">MEEDRAQVAIFALNEKCGDETQKVQRMVKKHQSDKSTSSGAGKIQATKLRTVDDSGQKCSSLLTRQVADSTWEERAICFFFDQYTCSSETGECISHLGFLPSLYALCRDASEKECPASSSSLRLAVDATALVTLSNEIREPSLIVKARYLYGMALQRLRQALQSRTQAVRDETLASVVLLSIFEDITGERNGLASSHTVGLEMLMKLRGMSQFGHAQGRDLFNFAYTHTHTEFLALGDKPRFKTDWIAGLLDSADPVHRLMLLASKVSQIFLESSSLQASAGAEEVGRLVSCIEDAKSVDLEFAAWSQGLPDNWLPLIIYTQTHESLMTYQQITIAAIWNYYRAVRIILLKVILRLRDQLASAVGAFGVCSERLQGEPMILESIQEMITDVCRSIPFAFGHVDAMGNAIPTSSEGKLHIRAFQGYSMVWPLWYISSCGLATPEQSHQVRTVLARVGSTLGIKLALILAGEGEVDYMAPTAQGDTIVRKATVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSS0</accession>
    <name>B0XSS0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sterol delta 5,6-desaturase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_017380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017380"/>
    <dbReference type="HOGENOM" id="CLU_047036_3_0_1"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="PhylomeDB" id="B0XSS0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="8">
        <location>
            <begin position="160"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="335" mass="39325" checksum="609AB6F5482D4443" modified="2008-04-08" version="1">MDVVLDVLDTFVFDKLYALLLPAKSFDLLDQDSVVDYNSHINRYVTLTPSQYAVESSLARDNILRQFLSLFITIWAFGLLLYLTTASLSFALVFDKRAMQHPKFLRHQIRLEIGQALRAMPVMAALTAPLFLAEVRGYSKLYDFPTGSPFPLYIYLQYPLFIAFTDFAIYWIHRGLHHPAIYKRLHKPHHRWIISTPYASYAFHPVDGWCQSLPYHVYPFLFPLQKAAYLGLFVFVTIWTVMIHDGEYALDSPVINGSACHTIHHYYFNYNYGQFTTFWDRIGGSFRRPNRELFDKQQRLQQTEIQRQVEEMERLVKEVEGSDDRCYEQDTKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSS8</accession>
    <name>B0XSS8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_017460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017460"/>
    <dbReference type="HOGENOM" id="CLU_020129_1_0_1"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="PhylomeDB" id="B0XSS8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757847" evidence="1">
        <location>
            <begin position="21"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="230"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="684" mass="74434" checksum="0897954F86F15E71" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT02</accession>
    <name>B0XT02_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="9">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_028400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="9"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028400"/>
    <dbReference type="HOGENOM" id="CLU_041805_0_0_1"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="PhylomeDB" id="B0XT02"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760139" description="Alpha-L-arabinofuranosidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="332" mass="36429" checksum="50CBECA505EB212B" modified="2008-04-08" version="1">MKLFLLLLISALAAAAALPSSFKWSSSGPLVEPKKDGRNIAAIKDPSIVKVDGTYHVFASTATKSGYNLVYFNFKDFSQANQATFHYLDQTPIGSGYRAAPQVFFFKPHNLWYLVFQNGNAAYSTNPNIANPAGWSKPKNFFSSMPSIIAQNKGNGNWVDMWTICDSSNCYLFSSDDNGHLYRSQTSLANFPNGMGNTVIALSDSNKNALFEASNVYHTGNGEYLLLVEAIGSDGQRYFRSWTSNSLTGSWKGLANTEANPFARSNNVAFSGTPWTKSISHGELIRTQTDQTMTISPCKLQYLYQGLSPSAGGDYDLLPWKLGLITQTNSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT47</accession>
    <name>B0XT47_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pfs, NB-ARC and TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_017990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT47"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017990"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_3_1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="PhylomeDB" id="B0XT47"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="4">
        <location>
            <begin position="577"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="822" mass="92044" checksum="87087AB12509F7A7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT48</accession>
    <name>B0XT48_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="9">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_018000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="9"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018000"/>
    <dbReference type="HOGENOM" id="CLU_041805_0_1_1"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="PhylomeDB" id="B0XT48"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760141" description="Alpha-L-arabinofuranosidase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP53757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="396" mass="42961" checksum="025EAF898CBE97F7" modified="2008-04-08" version="1">MKAIGATLLGLALVVQAQQPFYAQCGGNGWTGSTQCVAGACCSSINDWYYQCLSGNCMPSTTMTTTTATHTTSTSTSGATGSLPTSFRWSSTNALVGPKNDGRNLAGIKDPSIIEVDGTYHVFASTAQASGYNLVYFNFTDFNQAGNAPFFYLDQSGIGTGYRAAPQVFYFQPHQLWYLIFQNGNAAYSTNKDISNPAGWSAPKNFFSSVPSIITENIGKGYWVDMWVICDSSNCYLFSSDDNGHLYRSQTTLSNFPNGMGNTVIALSDSNPNNLFEASNVYRVGNEYLLLVEAIGSDGNRYFRSWTAPSLTGTWTGLANTEANPFARSNNVVFSGTAWTKSISHGEMVRSQVDQTMTISPCKLRYLYQGLSPTATGDYNSLPWRLALLTQTNSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT92</accession>
    <name>B0XT92_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_018450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018450"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_2_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="PhylomeDB" id="B0XT92"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF8">
        <property type="entry name" value="PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="524" mass="56535" checksum="1ACADCA31AA34950" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTD1</accession>
    <name>B0XTD1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_028990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTD1"/>
    <dbReference type="SMR" id="B0XTD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028990"/>
    <dbReference type="HOGENOM" id="CLU_094271_0_1_1"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="PhylomeDB" id="B0XTD1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="207" mass="22153" checksum="649BC238E3FD1443" modified="2008-04-08" version="1">MADILTQLQTCLDQLATQFYATIGYLSTYHDNSPAIPPPDVPDAAPALAKIPKNSTAPPVPAGAPVPALSQASPPAQNPAHGAAGAGTSVGEGAQTPGPAAGAGADPNLPAPDSPRTFASRQRELARDLIIKEQQIEYLISVLPGIDSSEAEQEKRIRELEGELRQVEEERELKMRELKRLRRTLENVLTAVETGLYGDRELLEKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTH1</accession>
    <name>B0XTH1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_018560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTH1"/>
    <dbReference type="SMR" id="B0XTH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018560"/>
    <dbReference type="HOGENOM" id="CLU_078857_0_0_1"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="PhylomeDB" id="B0XTH1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="241" mass="27492" checksum="1931F95C5A474B71" modified="2008-04-08" version="1">MGRVLQKKKNRSSTPKQRPKRTGQLKSGKKKINVLGNAIIAQNWDRKLTLTQNYRRLGLVHKLNAPTGGSEKKPTKDGRIEELPEDPLHIRSSAKASAKQAAMGETRVERDPETGKIIRVIRDEEEIEIAGRKVKPSNPLNDPLNELSEDEAARQPASQRTNAKSAVVQQLERQADQEGKAVKAKKPRHQSKREEEWIMRLIERHGENYSAMARDRKLNPMQQSEGDLKRRIRKWKANHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTI0</accession>
    <name>B0XTI0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_018650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018650"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B0XTI0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="457"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="689" mass="77740" checksum="B22CFEC08BD678EE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU17</accession>
    <name>B0XU17_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="8" type="ORF">AFUB_019850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019850"/>
    <dbReference type="HOGENOM" id="CLU_044783_1_1_1"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="PhylomeDB" id="B0XU17"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="355" mass="39376" checksum="940A7FC4959814C7" modified="2008-04-08" version="1">MADENHPAHLSPSELGTKNYWETYYARTLAHLSSKHQPNARPTPTADADADSAESESETESVDDDDDPGTSWFSEHNAPEKVLRFLTDESFPLAPCNTLPATSTAKTAAKKPQSDEERGRQPSILDLGTGNGSMLALLRKRGGFRGVMVGVDYSARSVELARELQRLKIHSAYLSGSESEGEEQEEGEEEDVVVSNGAETAEAIPVPEEDKDMMIRFEEWDILNSEGQLEGEGRLDWFPYAQGGFDIVLDKGTFDAVSLSEEVVVEGKSEGKVIQRRVCERYPSIARRLVRKGGFLVVTSCNWTEEELVRWFTGEEAKGPGADRLEVWGRVEYPKFRFGGQEGQGVCTVCFQRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU98</accession>
    <name>B0XU98_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catechol dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_019980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019980"/>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="PhylomeDB" id="B0XU98"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="106"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="287" mass="32533" checksum="7F97F1540975DE08" modified="2008-04-08" version="1">MATHRFDPNFTDNVINAMGPKTNPRFRKVMASLIRHVHDFARENELTVDEWMAGVKLLNWAGQMSDDKRNEGQLVCDVIGLESLVDEITFKLADEAADAPTATAILGPFFRADTPYRNNGDNIVKDVPDGEMVFMHGRVIDFQTKKPLVGATVEVWQASTNGLYEQQDPNQEEFNLRGKFKTDADGRYYFYCLRPTPYPVPNDGPAGKLLELMDRHPFRPAHIHIIATHDGYKPLTTQIFDRQDKYLTNDSVFAVKDSLIVDFVPRKDDPQAGLELEYDVKLVADQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUR8</accession>
    <name>B0XUR8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_021030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021030"/>
    <dbReference type="HOGENOM" id="CLU_1342959_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0XUR8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF145">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="204" mass="22531" checksum="F850E3A0C13BD681" modified="2008-04-08" version="1">MQLRLAYGGPHGMTVSWNTYSQLPHPTVCFGRSPKLLNRCVSSSASIIYTTSMINSNHVSIAELEADTLYYYLPQHSNATSPYTFKTSRQAGDQTPHTVATAIMMAPLIGSTTSRTMLASACLARPTLPASETTSACPALSLVNCREVWEPLFWKYNVDLVLSGHANYYERNAPIANFNVHPNELNNRMPHGPLPTELQVIIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUV7</accession>
    <name>B0XUV7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_031590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031590"/>
    <dbReference type="HOGENOM" id="CLU_834198_0_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B0XUV7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF199">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15915)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37018" checksum="AE33027105161858" modified="2008-04-08" version="1">MSKPLQGTAIITGGNGTLGSEIAIAIAKTQPYVHLLLLARDIRSDSVKDLLQKIRLIGPRSVEVAKVNLASFNSVVSFCQNTVERVRTKEIPPVMLLINSAVMASYVTDPVTPDGYDPVYQVNCIAPFLLTVSLLEAFRAGNGTPDGGARVINIGCSAISCGSLDYFDDSPDNPPKPPGTPLSAKEGNARLGSSKLIMSAAMYALRRSLVLTGNMSLNIYTLDPGGLEGKRHLTTDAPLSVRMAQSTRSSLGPFLRVFSKSAINKASVPAKVIAKVAFQRETVELWGRERYYILDSDYEAGSVILALRDPPLMDSLLKKMLRHVEIGVKGMGSPDSRISRVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV41</accession>
    <name>B0XV41_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bys1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_021570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021570"/>
    <dbReference type="HOGENOM" id="CLU_083650_1_0_1"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="PhylomeDB" id="B0XV41"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF5">
        <property type="entry name" value="BYS1 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G04533)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760487" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="177" mass="19006" checksum="7661E89B83D9D022" modified="2008-04-08" version="1">MHLNLISLTLCLSPLALALPPHSLLRKPPMTPNTNQTVGHALVHNTCTSPIYLWSVGSTIGPQSAVSPNTTYTEVYRRDPASGGIALKITRVADGLYTAAPQMVFAYNLVGEQVWYDLSDVFGDPFLGSRVRVEYRGLAGEAEDEAKKSIEWADGMSPGGSMVRVAGAEGDLILMVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVD2</accession>
    <name>B0XVD2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_032710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032710"/>
    <dbReference type="HOGENOM" id="CLU_012441_3_0_1"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="PhylomeDB" id="B0XVD2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="8">
        <location>
            <begin position="128"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="488"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="692" mass="78416" checksum="5669FD7856E0920C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVL7</accession>
    <name>B0XVL7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_032890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032890"/>
    <dbReference type="HOGENOM" id="CLU_1678397_0_0_1"/>
    <dbReference type="OrthoDB" id="4427478at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="177" mass="20093" checksum="20C7A68ECE7B8A4D" modified="2008-04-08" version="1">MSRNQSTPPAKDKEPKKLEDLEDNTVLEIITHSLQRDNLAPGGLVLRENFSALDRRHLPYPKWRCNECHFEFATAKLRDRHEASHWHTSGGESLGMSLMGYQSLLDRAWPSCHVPDSAQANEKDIGIPEPSRQLVFEEFINSPREYKHDGLPPAPHIYPVPYVGTEEASILKAAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVV4</accession>
    <name>B0XVV4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_022890</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022890"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_1_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="PhylomeDB" id="B0XVV4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase_N"/>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
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        <property type="entry name" value="HAD-like"/>
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        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="908"/>
            <end position="929"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="39"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1061" mass="114133" checksum="747FC895198C8747" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVW5</accession>
    <name>B0XVW5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">AFUB_023010</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
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        <property type="protein sequence ID" value="EDP54248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_002979_0_1_1"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="JHD"/>
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        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
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        <property type="entry name" value="JmjC_dom"/>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
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        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="331"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="22">
        <location>
            <begin position="588"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
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        <location>
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        <location>
            <begin position="891"/>
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        <location>
            <begin position="1090"/>
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            <begin position="1130"/>
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        <location>
            <begin position="1250"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="44"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="61"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="127"/>
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            <begin position="143"/>
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            <begin position="308"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="907"/>
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        <location>
            <begin position="1130"/>
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            <begin position="1186"/>
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    </feature>
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            <begin position="1251"/>
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            <begin position="1341"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EDP54248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1418" mass="157314" checksum="45C31D12EC07C26A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW95</accession>
    <name>B0XW95_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_024030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024030"/>
    <dbReference type="HOGENOM" id="CLU_2557855_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="82" mass="9142" checksum="88F054B0DDF5281F" modified="2008-04-08" version="1">MQGKKGEAPTIIAFALVGNDIRFDHIGLLVNHEDETSAKQRKEWYGLRGHRRSVGADSRTHGADQGLESMHSSRTLYPALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX51</accession>
    <name>B0XX51_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1275 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_047760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047760"/>
    <dbReference type="HOGENOM" id="CLU_061825_1_2_1"/>
    <dbReference type="OrthoDB" id="5223589at2759"/>
    <dbReference type="PhylomeDB" id="B0XX51"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="239" mass="25605" checksum="DBA35AF8691D21A5" modified="2008-04-08" version="1">MAPLSSIWAYLNEDISEDLLLECQLLLLSFATGIQDAATWPDYSCFASNQTGNTLFLAIGVAGLANNAYSFPNIGMSLGMFIAGGLLVGQLGNLFGVRRRLWLLLSSVIQTVLVVVGLIVQYTLPVKQEGPAALGVIACLAFSSGAQVAMSRSLKITEITTAMATAAYVDVVVDPGLLRVHNRPRTRRVLFLVMLTAGCFVGAFAQRAVNSSFALLWCAVGKAVVTVSLLWNKRLEKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXZ7</accession>
    <name>B0XXZ7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_039120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039120"/>
    <dbReference type="HOGENOM" id="CLU_025395_1_0_1"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="PhylomeDB" id="B0XXZ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="478" mass="52511" checksum="AC96935767ABFB40" modified="2008-04-08" version="1">MTDYLYDLLAPHFSPADATSTPLAPDHDTTTAQYLNRLSTLSLEALETSEPQSLAQSSHSTLLSLQALSNRSHKAFITSAGNLSQLRISIPQLTCNTQNLRDAIPKLDEEAVQFSTKYSRAAENPSLERRKKVMQLARNVDRLADILELPSLLSTAVSSAATSSVAAGGTSFSTTYSSALDLYAHIKRLQTLYADSPLVKEVASQAEDAMKEMTTNLIAGLRTQNLRLAAAMRMVGWLRRVAPELEGFHSDGGTGTGEGALGALFLVCRLANLVSTLEALDPLRELADQETQRRTQNTDQKEGTSNSSWSHGHQTEKFLKRYIEIFREQSFAIVSLYKNIFTPDQAESESVIAGLRGIDSRVKTNLSQPTRPDDPLQCLPPALATFPMHLVQLLTDTLRTYLPNVQDKSSRESLLTQVLYCAASLGRLGGDFSMILTEMSAAYEWEEVTRKHRALAGRLEQLTGTASRVTPRVTSPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY44</accession>
    <name>B0XY44_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_039590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039590"/>
    <dbReference type="HOGENOM" id="CLU_042177_1_0_1"/>
    <dbReference type="OrthoDB" id="5391950at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="274" mass="30066" checksum="CEEFD74B8C13A3A5" modified="2008-04-08" version="1">MPPSRPTMLIGSPYRKRESSDSGCDSPPASYFSPASIASHQEARLLEEEDLGRHSPRAAVAGRLGALAIHSENNSSLSNSDASLHKDPFVDSLRTKCWVDSYTGLHDMAENTSTEPSDFGSNGFSEENDHLHNANSAASASTSASIVKEKSLSSPRKRKATSGDTPRMCHKQGSPSPDSTMEDNSLTWNDSEITGHDPNDPNDDGYGINGIGFKPTAAIAWARAQKRQRQVAEWKSREAREAREKRREKRDGHGFDKLRSIQSGTIQKRVKFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYN5</accession>
    <name>B0XYN5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_041530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041530"/>
    <dbReference type="HOGENOM" id="CLU_1094053_0_0_1"/>
    <dbReference type="OrthoDB" id="4467576at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="254" mass="29457" checksum="695A3F1AA32305AA" modified="2008-04-08" version="1">MLYRNTDICVRQEEDPLVGCCTCEFTKKKGQYLQSSDCSPGDDLTFISELSPPQPSQYTASRSHDENPRISFAYLANLTHCWMTCLRLSYYLADYTVQHHLQYDPEAKPLWSSCKTEKEVVYSRAVGVLQSRLLCPLETRKHHHLHHLLEEQQSILQWPPFTTTEVFLSTHHCMTPEFPPSRPKAGVNFSSRLRTINLQKPSAHNRNVSSTWTKRREFVLRMRKDCCGGGYQCPWVVTKRPLPPRSRRCSLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ27</accession>
    <name>B0XZ27_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hexaprenyl pyrophosphate synthetase Coq1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_042930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042930"/>
    <dbReference type="HOGENOM" id="CLU_014015_1_0_1"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ27"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="450" mass="48870" checksum="41A3E55ABE71A8A9" modified="2008-04-08" version="1">MRARTVSASGLVLSSRRTPSTSICWQCLRDDLSKQLQTHARNYHPTRRKDASPFGAAVSAAQTIFKGLPKAPPGISVDPLRIVGKELKFLTKNIRQLLGSGHPTLDKVAKYYTRSEGKHMRPLLVLLMSQATALTPGKSRPNDVAPISVNDPISSPSILADTNPDTNSLVSESAEAQYDFVGDENILPSQRRLAEITELIHTASLLHDDVIDNAVSRRSSNSANLQFGNKMAVLAGDFLLGRASVALARLRDPEVTELLATVIANLVEGEFMQLKNTVADEKNPVFTDETISYYLQKTYLKTASLISKSCRAAALLGGSAPEVVEAAYSYGRNLGLAFQLVDDLLDYTVSGVELGKPAGADLELGLATAPLLFAWKQNPELGPLVGRKFSQEGDVQRAREIVYNSDGIEQTRALAQEYADKAVAAIADFPDSEAKSGLIQMCEKTMNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZJ1</accession>
    <name>B0XZJ1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">molybdopterin adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_034050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.75" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034050"/>
    <dbReference type="HOGENOM" id="CLU_010186_0_0_1"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="PhylomeDB" id="B0XZJ1"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000006">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000015">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF30">
        <property type="entry name" value="MOLYBDOPTERIN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5 6" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="202"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="447" mass="48517" checksum="A3C390D38E1EACEF" modified="2008-04-08" version="1">MAILYSEALRLIQAEAQRHRNAFLADGEHVPIGQARDRISRETVTSTISTPKFDTSAMDGYALSSSATQDATIDHPVTFEVKGMIAAGDEPLWIAADEQSGTPVCVEIMTGAPFPTGVGGNELDCCVRNEDVAVTVDETSNRRYIRVVKPAKTQQNRRFAGSDFKKSDILVDAGEVIHPGHILSMASVGMTQIAVTRKPRVAVVSTGSELLPPGLDQSPLHRISDANGPYLTATLESWGATVDFLGIIQDHAEDLEQALRLTLGQKAYDVIITSGAVSAGRCDLIRRLNARVVFHKVAMRPGHPVLFAQIPDSSNTDGHLRRETAFFGLPGNPVASAACLRFLVLPYLKYLQLQRPDDPSSASLLLPDDAETATTKEHPVVSTFCGDMDVFRPALVRGSSGHVQVKLIQDHSPGKIRPFLHSNCWIHIHRGVSELKAGDIVDIYPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZP2</accession>
    <name>B0XZP2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044740"/>
    <dbReference type="HOGENOM" id="CLU_1927107_0_0_1"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="131" mass="13568" checksum="DC018EE1731A58E4" modified="2008-04-08" version="1">MLWDAALSLIGESSLTAEVKGGLTMCESTFEALGTPFADRAAELIGVFMTQSTALVGDAYSKLRNRGNTANDENPAQQCGIGPVMEADGGDMTGDEPGLEQMMLGQTSNNLRLGFQLDSLADAASSSASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZY2</accession>
    <name>B0XZY2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_034780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034780"/>
    <dbReference type="HOGENOM" id="CLU_026584_0_0_1"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="PhylomeDB" id="B0XZY2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="349" mass="39620" checksum="7AFA5E66A7DABE7A" modified="2008-04-08" version="1">MVSSENSLKHSSSTPSEQQGPDRKRLKRSYHHHHRLRNPVIPALPEPAINDDAHVAHLMNRSIGLCLRESGFDLADPAALESFRYATEEYLLKLASFVQQSMLSSRRNHPIPQDFELAFKRHHLHVDDLLPHLKPLPNIEPVPTLLPSPPPEEVAWLDLPFLGSELSGESDRVRSAYIPKHFPQFPSKHTYRHTPVFTQREQDPRKIRERATEEGRHGEEALRKLARASFKDNQLGWAGREKRLWGRRMESLDSMFEKTVKGIAKKMHKDVTAPGTVAAMDIDSGVAVDPELKATRPKLPFSLELPPVINCERGLWRRTAAPSNRKAEEKPAGTKDPTSVSRVESWMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZY9</accession>
    <name>B0XZY9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endosomal sorting complex protein TSG101, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_034850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZY9"/>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="PhylomeDB" id="B0XZY9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="512"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="579" mass="62556" checksum="E98CB534F8942839" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y051</accession>
    <name>B0Y051_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_045640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045640"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B0Y051"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="903"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="903"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="935"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2463" mass="272022" checksum="1072DC18EA32BA6D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0F1</accession>
    <name>B0Y0F1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_045960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0F1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045960"/>
    <dbReference type="HOGENOM" id="CLU_007884_14_1_1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0F1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="438" mass="46829" checksum="1770D0272AECA97B" modified="2008-04-08" version="1">MSTVILGGGIIGSSIAYYLSENGSSDEIHIVEASSQLFSAASGYAAGFLAKDWFTPALASLGELSFNLHQSLADKNGGRQEWGYMKSTALSLDFSKNNNKRGASGDDWLSTGASRAEAATSSSSPVHVEVPAWLTKQKKGIIEKISDDDTVAQVDPLRLARFLMESSLSRGVKLHNPAKATSVITDQVSGYITGVKVMNLDAQTECTLPCANIIICAGPWTPQVYHELFPLSRLPIPITPLAGYSLVVRSPRHTLQDERVTYANRSHAVFTTHPDSCGFCPEIFSRQGGEIYIAGLNDTHIPLPAQAGDSCKLMDQNEMRRLKKVAVHLMGAQEEGNVESTDGIANRNDLEILREGLCFRPVSAHGVPFVARIDDHLLGGPKTGSINRCENGITRGGVFVASGHGPWGISLSLGTGKVISQMVEGVEPDVDVGGLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0U0</accession>
    <name>B0Y0U0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_058520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0U0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058520"/>
    <dbReference type="HOGENOM" id="CLU_009650_2_1_1"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0U0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="73509" checksum="3C1B2A8C81521849" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y141</accession>
    <name>B0Y141_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_059530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y141"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059530"/>
    <dbReference type="HOGENOM" id="CLU_020681_0_0_1"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="599" mass="66525" checksum="3BF4E2FA70E0824B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y166</accession>
    <name>B0Y166_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase, classes I and II family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_048850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y166"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048850"/>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B0Y166"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="55"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="443" mass="49907" checksum="BE6CA09C19B7A2E3" modified="2008-04-08" version="1">MGSITPPFSSLPRSSESYFSTRGQSALDQGRKRITWDVISDMWHPQRNPSGILSIGMAENTLLHDTLLEYIHANIRLSAEHLTYNNGSMGSHALRKAVSHFLNRQFKPFRPIEPSHVLVTNGCSSAIEHLSWTFLNPGDAVLLAMPYYSTFIADLSLRPEAVVVPVHLAGFQDPLDPKTIDKYEEAAVEFEACTGKKVRAVMLCNPHNPLGRARGMHLISDEIYALSVWNNRVDNPDNAPFTSFESVLSRDTTNLIDPSLVHVLWGMSKDFGANGLRVGAVISQSSPDFHIAQKCLSLYSFVSSLSDQITTSILMDDTFTNNYIKMNREKLSECHEFLALLLDKHRIEYMHGCNAGFFLWVNLGKRYLEAHPDEQKVGQREGQDEWGTKLTDVIFQKLLDNKVYVAHGTAYGSEKPGWFRLVFSHPLPWLEEAMARIIRAITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1H3</accession>
    <name>B0Y1H3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear pore complex subunit Nup192, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_060330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1H3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1614" mass="179725" checksum="2F7AAADB26F9FD43" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1N8</accession>
    <name>B0Y1N8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_049960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1N8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049960"/>
    <dbReference type="HOGENOM" id="CLU_043034_3_1_1"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1N8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760759" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="96"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="205" mass="22045" checksum="AABBA7A649465B01" modified="2008-04-08" version="1">MTRLLLSVLLGIPLVAALPVALPTPPGIPSAATAESELAALTVAAAGSNDGYSRDLFPHWISQGGSCNTREVVLARDGTDIVKDSSCYPTSGSWYSPYDGATWTQASDVDIDHVVPLANAWRSGASKWTTAQRRAFANDLTNPQLIAVTDNVNQAKGDDGPEAWKPPLTSYYCTYAKMWVRVKYVYDLTITSAEKNALVSMLDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1R1</accession>
    <name>B0Y1R1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1264 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_060500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1R1"/>
    <dbReference type="HOGENOM" id="CLU_071931_3_0_1"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1R1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="202" mass="22614" checksum="8D81AA8DF2515CFB" modified="2008-04-08" version="1">MQTCIAQQCLVINTFPETKMGSLARLSAPKAVSWKAAPAWFKISHLRQCLIYDSTKPNARLIGVEYMISPRLFETLPSEERKLWHTHEFEVKSGMLIMPAPAGVPKPAWEAAETSEMREVILLYGKTYHFWQADRGDPLPLGAPQLMASFTSEDKVKLVQPKGLDGLLAGRDEAFGVDYKVKAEKRKDIEPPNLSPDADTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y225</accession>
    <name>B0Y225_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol polyphosphate phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_050670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y225"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050670"/>
    <dbReference type="HOGENOM" id="CLU_002027_1_1_1"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="PhylomeDB" id="B0Y225"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001686">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="807"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1197" mass="133373" checksum="D20B5ED74E112FA3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2L3</accession>
    <name>B0Y2L3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lactase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_062230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2L3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062230"/>
    <dbReference type="HOGENOM" id="CLU_002346_0_0_1"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2L3"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000680">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000026">
        <property type="entry name" value="Beta-galactosidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000125">
        <property type="entry name" value="Intracellular beta-galactosidase BgaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF1">
        <property type="entry name" value="LACTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="10">
        <location>
            <begin position="762"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118272" checksum="FC3DBAA7E3A99768" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2M7</accession>
    <name>B0Y2M7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_062370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062370"/>
    <dbReference type="HOGENOM" id="CLU_3368357_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="35" mass="3848" checksum="D2ABFA6D42A2A374" modified="2008-04-08" version="1">MGWLSPILLNGLATPHTDEARHWAGALELGRDYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2P9</accession>
    <name>B0Y2P9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_051530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2P9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051530"/>
    <dbReference type="HOGENOM" id="CLU_026535_0_1_1"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2P9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="280"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="373" mass="40504" checksum="F65E43674B66AFB4" modified="2008-04-08" version="1">MASRPTVTIATADGKPSGATLPLPAVFTAPIRPDIVQQVHTGMAKNKRQPYAVSEKAGEQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNQCRSGRMFAPTKVWRKWHQKVNLGQKRFATASALAASSVPSLLFARGHRIANVPEVPLVVESKTFENAAITKTKAAIALLKALGAGADLVKVQKSKKMRAGKGKLRNRRFRQRRGPLVVYNPEVDGKELVRAFRNIPGVETSSVFSLNLLQLAPGGHLGRFIVWTSAAFEALDQVYGSTTTPAALKKDYVLPQNLVANADLARLINSSEIQSVLRAPKGEARTKRAVVQKKNPLRNKQVMLRLNPYAAAFSKEKLGQKPVESKEKPARPAQEFINTLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2U7</accession>
    <name>B0Y2U7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_052030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2U7"/>
    <dbReference type="HOGENOM" id="CLU_049047_3_1_1"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2U7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="194" mass="22281" checksum="D8D744A3C215C3BC" modified="2008-04-08" version="1">MHDDVNIPVIRVFYWFGHYYSLSLLVQAVIMIGVQIVLLKVALDNRPSPGVKNSVEHVPFSNLDEKGFARPYEFWQWKSAKPYWMFLAYFVGALSFVQILLPPIARSDFYVSLLGYAGLAVEAILPLPQIVANHRTRSCKGFRVSVLAAWILGDVMKMSYFFCSKEVIPWAFRLCGMFQCACDLYLGVQFWIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y300</accession>
    <name>B0Y300_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_052450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y300"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052450"/>
    <dbReference type="HOGENOM" id="CLU_015090_0_0_1"/>
    <dbReference type="OrthoDB" id="1278353at2759"/>
    <dbReference type="PhylomeDB" id="B0Y300"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="170"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="740"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="875" mass="97243" checksum="922880473B7B8187" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3A2</accession>
    <name>B0Y3A2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA processing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_053470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053470"/>
    <dbReference type="HOGENOM" id="CLU_040063_3_2_1"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3A2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="196"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="425" mass="48693" checksum="BD59430E29A53BCC" modified="2008-04-08" version="1">MGSKKSQSKPPPSAALDYKPANKLRRQMLHVKRKRAKDSERRAERFGRKKEEAKNPKLKEERLKRNIPLTLDRKRVWDEADSDVEEALGLSVDVERIKRQKKEEEDELNRPLDDKDSGSDESEDDVDSMLATSDEEEDGDEKAKKDDNRGRKKSSLPSATERATSPSQSTRSTNLNLAPEALAAKFPTLFPSEPHPTPKILITTSLNSTLHNEARSLTDLFPNSVYIRRTAHRYSHKFSIREIAAFASNRNYTSVVVLQEDQKRPSGLTIVHLPQGPTFHFTISRWIEGKKLPGHGNATEHRPELILNNFRTPLGLLTAHLFRSMFPPQPDLEGRQVVTIHNQRDYLFLRRHRYVFREKRETEKSVVGTDGKEIKGVEGIRAGLQELGPAINFKLRRVDKGIQRASGQEWEWKGGMEKQRTKFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3E1</accession>
    <name>B0Y3E1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair and transcription factor Ada, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_053880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3E1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053880"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_3_1"/>
    <dbReference type="OrthoDB" id="2447880at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3E1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00165">
        <property type="entry name" value="HTH_AraC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="228" mass="25090" checksum="C41007C5F230C425" modified="2008-04-08" version="1">MHVVDDSNDAPKILPLPRAAPSTSAAARWQAVVNRDAAANTFVYAVLTTKIYCRPSCPARLARRANVRFYDTPSQAESAGFRPCKRCKPEMHWAANPQVQLIQKACETINLEVLNGCKPTLQKLASEANLTPSHFHRVFKKVMGVTPGQYSAAAQDCRNRNASVDSGLGEDWSLNRPLCDDGVCYDPDLLGGLDDSHAPTTTDAVVWNDFDAMIAAENEYILWPDEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3P4</accession>
    <name>B0Y3P4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B12 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_054930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054930"/>
    <dbReference type="HOGENOM" id="CLU_145518_1_1_1"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3P4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="82" mass="9552" checksum="5C8411A9D6E847FC" modified="2008-04-08" version="1">MANPTGFDINEFKAAASPRSVYAKRDPWARYEAWRYTGPFSRFNRFKHIFPGFGIASVAFAGYCVYEHFFLKDEHHHGEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3V2</accession>
    <name>B0Y3V2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine permease transcriptional regulator (SAC3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_055530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SAC3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP51543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_001529_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000008">
        <property type="entry name" value="Nuclear mRNA export protein SAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="6">
        <location>
            <begin position="222"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="636"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="965"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="1175"/>
        </location>
    </feature>
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            <end position="55"/>
        </location>
    </feature>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1104"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1149"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1230" mass="134377" checksum="800896412D8F3267" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y401</accession>
    <name>B0Y401_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_056030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056030"/>
    <dbReference type="HOGENOM" id="CLU_076914_0_0_1"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="PhylomeDB" id="B0Y401"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="216" mass="24625" checksum="F87503ACC756EC47" modified="2008-04-08" version="1">MTAETQGICPPAAFRSAFLGITRTDMPHFPKGTGFEMDSDGAERNIKSSSVQPSPAMRVKNRRKRYLDMHPEYFSADLEVAEREAEGRAKGFSGILQADLQRSEARLDALHNPNPNAMSSYSRGPSGEIIAEDADEIPTNKEEAEKLWRWEMTMRFLKGEDCDFDYTQVDENDEYDDQTEEQERYFDDEEPEWMVEGADDGDIKSRLQGETGIQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4B7</accession>
    <name>B0Y4B7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_057190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057190"/>
    <dbReference type="HOGENOM" id="CLU_026445_0_0_1"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4B7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="501" mass="55094" checksum="9BD06FB17FF93E2B" modified="2008-04-08" version="1">MGLFKRKDSKNSIQSDKDEQDSFASVNSARTSNASLRSPGYKGSGLPTSIPELPIARPPDPALDPAAYLRSIHAVRERSRIIFDKAKKNRLNHFDVDMTKFKATASYIVSIIKRDYAPDYSSIPPHGRWQHFDVGGRPRVNQLLQSWPSTIDAQERTRRLIDLFVVSVLLDAGAGTKWSYKSKESGKIYSRSEGLAVATLEMFKSGLFSSDPTEPCQVDGAGLKKITVEVLARGMQHSEHNPLAGLEGRAGLLMRLSEALNNQEFFGVDARPGNMLDYLLSHPSTLASSVPIVPITTLWTVLMDGFASIWPPSRTQVDGVSIGDAWVCSSMPQSPPAQPWESIVPFHKLTQWLCYSIMVPMAKLLNIHIAGSDLLTGLPEYRNGGLLIDMGLLALKDADLQRGIAAYKQNAQIKGQPNVEVVPLFAADDDVVVEWRAVTVGFLDDLLMEVNNQLGLRGEEQLTLAQMLEAGSWKGGREIAEVSRPNTKEPPIMILSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4G5</accession>
    <name>B0Y4G5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_069010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4G5"/>
    <dbReference type="HOGENOM" id="CLU_016701_0_0_1"/>
    <dbReference type="OrthoDB" id="3938867at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="86940" checksum="C7DAB5CA5BD68D99" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y515</accession>
    <name>B0Y515_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_071050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y515"/>
    <dbReference type="HOGENOM" id="CLU_045994_0_0_1"/>
    <dbReference type="OrthoDB" id="4470686at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="472" mass="51899" checksum="D32857144ECAC09D" modified="2008-04-08" version="1">MESLLEQATVEDGPCSNSFIDGKAPEALSTPPSLVDDSESLGGTPRDSLCPDTPCSKSLTYAEKQSADHASRLFPDDLVGDQRQSFGEVFCPPPKLSSVGIEHSISPESSVLDLDDYATMFSPHAEEPTMDQRAGPVQNSVVRDDQLLDSDSDDAPNCVPEKELCLSQLSSAHNREYAKGISSSGTDPSLDVNVDSSSSELNKIDSPAAEQPWSGNDISSPTADEAIPDEDSAGPSERPSDQRKPGRPKCQPSKKRNGSGVGSQRKKARLGLAEQLTEFVGCKISWQEIYRRFAGNCKSADSPEILTNLFFSIACQEAFVQLKKAIPQLRGSMKISFSAKTVFDNLKSLEQVASNLTAGRIMQRHLLVELVEHRIQLEDKYKPENYRRAKMIRENKRRLERSEGLALDEMIREAYPTVIKGSDEYNKYRTTLRNNLSSGRNPHTLAHEFGKHILDLIPVGEGLGKSNITDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y557</accession>
    <name>B0Y557_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_071470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y557"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071470"/>
    <dbReference type="HOGENOM" id="CLU_056399_2_1_1"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26982" checksum="CF54CA09B86D5BE1" modified="2008-04-08" version="1">MQSGIVDFVVGKSRKRFSVHAALASSFPKEILQPPLNGKVDEIVFGRCCEFVYSGDYSVPLPTGDRYGDDDDQPSDSQPLCQESARRWNPLNHQENMFHPSKLPDICAFIKKNLDKAPLDEDGEIPNTDPADNYVPLWCLSLYPLIRSLASFTLCEERTGDIVELLKFVFEENEYMYELKVVLVDYAAWNVEILMQDADFRQLLDRLCQLRLKSCKESVLFFLERDRKYTHVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6F6</accession>
    <name>B0Y6F6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH response protein PalF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_066760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6F6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066760"/>
    <dbReference type="HOGENOM" id="CLU_006001_0_0_1"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6F6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="295"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="757" mass="82149" checksum="56B4550A0D3C0F8D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6S8</accession>
    <name>B0Y6S8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DlpA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_068000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6S8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068000"/>
    <dbReference type="HOGENOM" id="CLU_072626_0_0_1"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6S8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="282" mass="30505" checksum="4B51195341002B2C" modified="2008-04-08" version="1">MNFVSRKRVIFEILPSHPTRRPRLIFSPFHVPSSQVQRRTMSNSIDQKLAELQKYSACDVSDALLKLQKLPAGTAARAGHLADFTPFSPSIGRNATQPKIIAPASTFKFIPKDDRIPPSAEPVDSHGFPAGTHWVDFAKPGTIAVLEQPANQHCAVLGGIMAVRMKVLGVRGVLVNGRVRDLEEINECKLPVWAKGTSTVGSGAEAKPGARDVPVDVGGVTVSPGDIIFCDPLEGVVAIPQELLDQVLELMPRLVAMDDKVKVAVSQGMSVFDAFKQFRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6V9</accession>
    <name>B0Y6V9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_068310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6V9"/>
    <dbReference type="HOGENOM" id="CLU_029048_0_0_1"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6V9"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP50494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="441" mass="48417" checksum="3AA732C14FD1FDD1" modified="2008-04-08" version="1">MSRMTVLSPSAGSQSACSLGLILVNPRRPLRSLSILFGLWKALIFLVIVICPGLGYDTSTSLLLYPTRDLSDVDPLHFPLSLRFVRWDSIYFVHAAEHGYVFEQEWAFGYGYTRLLALLASVLVLYRLSVNIFGGDTAKQKTLCFLSAALHIISPAGAFLSAPYGEALFSLLNISGLYLYSSSVLDAATNHRLSRDLKLLAAAVLISAATAVRSNGILGGVLFAYDALLQLPQILSRGLSLAVVSRLAVIVLGGCVIALGMAVPQYIAFNAFCMTSNAPRPWCGWTIPSIYRFVQEKYWNVGFLRYWVVPNIPLFLLAMPILALLLRSAFWAWRLPSVTSKFSENGANGALTKAMWLLPRLAIIQALLAVLAFTSYHVQIINRLSSGYPLWYWYLAAELISDFKNSQSTNKCISISAVAVQAIMIYGLIHAVLFGSFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6X8</accession>
    <name>B0Y6X8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_068500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6X8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068500"/>
    <dbReference type="HOGENOM" id="CLU_079429_0_0_1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6X8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000149">
        <property type="entry name" value="Zinc finger protein 569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP50513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="283" mass="32552" checksum="7BEA2F182D7F4F33" modified="2008-04-08" version="1">MAPGVGRDFNCSWEHCGKSFNRKSDLCRHYRIHTNERPYHCTVKDCNKSFIQRSALTVHSRTHTGEKPHVCDHEGCHKAFSDSSSLARHRRIHTGKRPYICQEPTCERSFCRKTTLTKHQHRSHPSGTMTRPPSEDAMSEQSYQAPVAAPIPNDQYLLAQQQYYHQPSTPSQEFYPPQSLPVTHIPVHDTPPIMTQSVPVTSPLDVQHAQQQYMQQLMQQRYDTTNQSYIPPGFQQQQQTFVAQPMAEGHPLMISYNQNFHYKQPTRILNQPEGTDWGFLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7U8</accession>
    <name>B0Y7U8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_075060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7U8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075060"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7U8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="543" mass="58353" checksum="8350922B845299BE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8F2</accession>
    <name>B0Y8F2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis acuK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_077130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8F2"/>
    <dbReference type="SMR" id="B0Y8F2"/>
    <dbReference type="HOGENOM" id="CLU_038697_0_0_1"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="653" mass="69915" checksum="85F06125F65F0FCD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8T3</accession>
    <name>B0Y8T3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_078470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8T3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078470"/>
    <dbReference type="HOGENOM" id="CLU_068908_0_0_1"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8T3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32590" checksum="BC506E63CD4A7519" modified="2008-04-08" version="1">MDSPLLSPAKARQAAIQAKDWAYVNSWLSRQYSPNPVPNFERNEDTLRTLLALAAANDAADEEAALLHRAREEAIRDFREREEAEDKQKRELLDELELCLGENGKRDLDDLAETTAVLGALHTGTKDLGQSLIELTVEEFDAQEELSKVGMLQKHLEKELAAVQEQLDQLKSDPAFEVPADLPAQTAEWSRSTKMLTAKLTEYQDRLATLGRKSSKDPTIEDLVTEEKQISQLKGIIQSLDHRLKMFHDLPKDIQGARAQYRQLERELNQLIERRDSMFESLVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8X2</accession>
    <name>B0Y8X2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_078860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8X2"/>
    <dbReference type="HOGENOM" id="CLU_004286_6_1_1"/>
    <dbReference type="OrthoDB" id="4227485at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8X2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="883"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="711"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="935" mass="106281" checksum="8B95323E9E953DD3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9D1</accession>
    <name>B0Y9D1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_080600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080600"/>
    <dbReference type="HOGENOM" id="CLU_019691_1_0_1"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9D1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000016">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF3">
        <property type="entry name" value="PROTEIN RDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="571" mass="62693" checksum="49C52063B13BEB85" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9M8</accession>
    <name>PLYE_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable pectate lyase E</fullName>
            <ecNumber>4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">plyE</name>
        <name type="ORF">AFUB_081630</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9M8"/>
    <dbReference type="SMR" id="B0Y9M8"/>
    <dbReference type="GlyCosmos" id="B0Y9M8">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP48721">
        <property type="protein sequence ID" value="EDP48721"/>
        <property type="gene ID" value="AFUB_081630"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081630"/>
    <dbReference type="HOGENOM" id="CLU_044863_3_1_1"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9M8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000044">
        <property type="entry name" value="Pectate lyase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF8">
        <property type="entry name" value="PECTATE LYASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394581" description="Probable pectate lyase E">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="254" mass="26828" checksum="EE1EFD82B50A1BF8" modified="2008-04-08" version="1" precursor="true">MYQPLLLLPLLLTSAFATPHDPTTHQALEKRASFPIPSSKGSVTYSSPKTISGTFDGGLKTYGRGVKCTGQKEGGEKDAVFVLEDGATLKNAIIGADQIEGVYCKGSCTIQNVWWTDVCEDALSLKGTGSGTHRIIGGGARNADDKVIQHNSGGKVIIQDFTVQNFGKLYRACGNCSKQFKRTVEISGVKASSGKALVGINSNYGDTATISGCASSVKEICVEYEGTDNNKKEPAKKSSGPSNACKYKEPLASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Z0</accession>
    <name>B0Y9Z0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA mismatch repair protein msh3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_082760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9Z0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082760"/>
    <dbReference type="HOGENOM" id="CLU_002472_4_0_1"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9Z0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000036">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000042">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000046">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000022">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000010">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="15">
        <location>
            <begin position="888"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="619"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP48833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113048" checksum="EDC3A71B60879EF1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAD1</accession>
    <name>B0YAD1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_084250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084250"/>
    <dbReference type="HOGENOM" id="CLU_2468615_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758345" evidence="2">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="88" mass="9271" checksum="686BA249EBB6A3EA" modified="2008-04-08" version="1">MKITAVVALALAAVVAASPVAEPKLVEPPLQAPARATVPLWRRAPAPSLVLRALVAIPPAITPSTLLAFVTIARERKSKMWKELDVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAD6</accession>
    <name>B0YAD6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase ALDH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_084300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084300"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B0YAD6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF3">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE ALDH (AFU_ORTHOLOGUE AFUA_8G02310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="95"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="568" mass="61561" checksum="C8BB98EE2DCD62C4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAJ2</accession>
    <name>B0YAJ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_084850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084850"/>
    <dbReference type="HOGENOM" id="CLU_028041_1_0_1"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="PhylomeDB" id="B0YAJ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="1">
        <location>
            <begin position="301"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="603" mass="66437" checksum="A179F4F64A753BDC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAT6</accession>
    <name>B0YAT6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_085780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085780"/>
    <dbReference type="HOGENOM" id="CLU_1721918_0_0_1"/>
    <dbReference type="OrthoDB" id="544298at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="152" mass="16585" checksum="FB172032450740C9" modified="2008-04-08" version="1">MSTCRLLHGINHSSLQRTDNSNSEEEEDVVALRSRNPYLSAASIITRSTGSAAFLGSCAMTIVLPIRMAGKERIEWQDRAWRLLENKGQVEVDTWSSIGMTAGIGMTAVIMRRNALRLEVWKHLVGGAALGNLAGVVGYLGWRYGVNGGHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB09</accession>
    <name>B0YB09_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_091160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091160"/>
    <dbReference type="HOGENOM" id="CLU_000690_2_2_1"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="PhylomeDB" id="B0YB09"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000034">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="577"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="879" mass="101024" checksum="A38A7A6CB08A2735" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB20</accession>
    <name>B0YB20_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanyl-nucleotide exchange factor (Sec7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_091270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EDP48410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091270"/>
    <dbReference type="HOGENOM" id="CLU_000691_1_1_1"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="PhylomeDB" id="B0YB20"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="798"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="759"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1192"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1698"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1207"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1720"/>
            <end position="1729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2004" mass="225425" checksum="4DFE68BDA659F099" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBR5</accession>
    <name>ALCS_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein alcS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alcS</name>
        <name type="ORF">AFUB_087570</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 2">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP48046" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48046.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBR5"/>
    <dbReference type="SMR" id="B0YBR5"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="PhylomeDB" id="B0YBR5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000393861" description="Protein alcS">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q460G9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48046.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29038" checksum="2F852706A0DC3B66" modified="2010-04-20" version="2">MDTEQGLKNHTAKTSPHDETAMASLTTIPTSVTLSAEQFEKLYLSPLTQRQGMLSKQMGNPTPLALGGFVITTTPLSCCLMGWRGATGSGIAFTGPIIFLGGGLLVLTSILEFILGNTFPCVVFGTIGAFWFAFGCTMTPAFNAAAPFSTSATDTVAGLSSPDFLNTYAFLFIWMGVLMLIFLACATRTNAVYVAIFTTLTLVFGFLSGAYWRLAVADALVGNRLVVAAGACLFVASMLGFYLLVAQLFDSVGLPVRLPVGDLSRFWDRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBX1</accession>
    <name>B0YBX1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial exoribonuclease Cyt-4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_088120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088120"/>
    <dbReference type="HOGENOM" id="CLU_002512_0_1_1"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="PhylomeDB" id="B0YBX1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="548"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1043" mass="117831" checksum="B468156CEA526BA9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCK8</accession>
    <name>B0YCK8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">dUTP diphosphatase Dut, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_090550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090550"/>
    <dbReference type="HOGENOM" id="CLU_103451_0_0_1"/>
    <dbReference type="OrthoDB" id="2874071at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002598">
        <property type="entry name" value="PRK02253.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680:SF3">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22769">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="171" mass="18802" checksum="310E15BB44953990" modified="2008-04-08" version="1">MIIPGRALLTRSIIRNVQNPALQVQPCGVDLTLKRILTWTSPGIIDLDNQRRQTASTNEIPFLAPSTTIPEERFLDLPQGSYLVEFNETVSVPLDMMGQIFVRSSLFRSGVLLTTGVMDSGYVGAVGALMQVLNPAGLRVYPSARLAQFVFHQMSEEVEGYSGVYQGRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCL5</accession>
    <name>B0YCL5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_090620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090620"/>
    <dbReference type="HOGENOM" id="CLU_028906_4_1_1"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="PhylomeDB" id="B0YCL5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="43644" checksum="0063344C186D9B35" modified="2008-04-08" version="1">MRIPCYGRSMFPEEKIQREVSVMRFLEFHTSIPVPHILRYGMAEESPDELGPFIIMEYIDHKYDLIDALNTPGIPDDERPMLDPQIAEERLIFAYGQMAGIMLQLSKHTFAEIGCIARANEDDDFDDVWVVKHRPLTLNMNELVQVGNFPPHLLPDGPFPTSSSYYRALADMHLAHLVTQRNDAVASPEDCRANCIARFLFRKLAREGRFCKYHERGPFKLFCDDFRPANVLTNAEFQVVGAVDWEYTYAAPLEFAYSAPFWLLLDLPEYWPGGLDDWTNVYETRLGTLLRVLEEREKVAIDRGLLSEEHRLSTYMREAGRVEISGFYGDGNLDDRLHLLTVEERQEVDDIVQKKMKEKEERKLTDWALSRHVEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDB6</accession>
    <name>B0YDB6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UMTA methyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_094990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094990"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_1_1"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="PhylomeDB" id="B0YDB6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33765" checksum="18D98FA3B4DE685B" modified="2008-04-08" version="1">MTKIDVINSGFNLGNELDYMLDRSYTAASRLNYQFYLWKDTLRFNLHPSIQLPKDESTPVRIADLATGTAIWLLDLLRDPAVARYKSIRLDGFDIDLANAPLPEWLPTPITLRQLSLFETVPGDLRGKYDVVHLRLLVLVVQNSDPLPIINQAYQLLKPGGYIQWDDLNYPDGAVVKANALRDVATPAHDAFLRFARSNGRNDWVLDLPRHLMSRHGGFEDAHIRNYTDRVELRKANGDQYILVMEEFSARLKRAGKMEDAHNIDLMIRGLAEESRRGVGLSMPKAVCVARKKVDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDU2</accession>
    <name>B0YDU2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_096790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096790"/>
    <dbReference type="HOGENOM" id="CLU_042941_0_1_1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="PhylomeDB" id="B0YDU2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31953" checksum="43A12036D3938F32" modified="2008-04-08" version="1">MARSESDKDIDANYGLLNNEEAQNWSHDEKPRTRSHGQWLKALLYIATVIVSCLVGLFIGRQVQDLDRACARHVSHYSPVTSDVDITFQPQRFNGSLLKENIYRQDASPEVDAAWEALGVNYRSLRVPAEVAEKSGLARDQVKINQKYGGGYPANVEGFHHLHCLNLLRQTLYYNYDYYHKLGQGAFKNDDFIVRRHVSHCLDILRQQLMCTIDTGVLGQVWIHPDHPEAYVDFNTEHQCKNFEAIRQYAEKNQLPAQIPKDFLEPPKPGDRVYDEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE47</accession>
    <name>B0YE47_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_097820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE47"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097820"/>
    <dbReference type="HOGENOM" id="CLU_1937668_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="130" mass="14154" checksum="469BD6012F332504" modified="2008-04-08" version="1">MVYNIIVCILCTFGIFGIFGIFGIFGIFGIFGIFGIFGIFGIFGIFGIFGIFGIFGIFDIFGIFGIFGIFGIFGIFMAWHSGVGCLVLLVPLLSRQSFGNSGLQYSPDAIRLAQAQITCCNNTSRMEHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEB5</accession>
    <name>B0YEB5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_098590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEB5"/>
    <dbReference type="SMR" id="B0YEB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098590"/>
    <dbReference type="HOGENOM" id="CLU_027965_1_1_1"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="PhylomeDB" id="B0YEB5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000011">
        <property type="entry name" value="Actin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000036">
        <property type="entry name" value="Actin-like protein ARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP47259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="468" mass="51791" checksum="BFBAC9E4DD07AF70" modified="2008-04-08" version="1">MGSTKPRTSAQASAPKVQSLPEKTFIIDNGAYTLKAGYAPGFPPPEDLGQALSACSTIPNAIAKTRGNRIYIGAQLNSQVTDWNEMVFRRPVEKGYIVNWEAQKEIWDNAFFDEKTVRSKDLRIESPEDTTLVLTEAPNALPTLQKNADEIVMEEWGFGGYVRFVGPVLNAWNEVQSLFGDPIGQDSSSPISPKQCLLVVDSGYSHTTVTPVYKGQPIQRAIRRLDIGGKHLTNYLKEMVSMRQYNMVDETYIMNEVKEAVCFVSNNFAGDLEQTWQGNRKRGLTDAAEGITVDYVLPDPNTGKKGFMRPHDPLSNAKKRKSILSGGNAEALSEDVLILGNERFTVPEILFTPSDIGMKQAGIPDIILQSLSVLPTGLHPSFLANVLVVGGNTLIPGFLERLESELRQIASAECVVRVRRPHDPIRSTWLGASRLAANRAELRKFAITRQEYQEYGSSWAGRKFSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEN4</accession>
    <name>B0YEN4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_099790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099790"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B0YEN4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="345" mass="37984" checksum="B6259E0C025CE249" modified="2008-04-08" version="1">MRAFGNRLALTHLPAMVATYNQGTRASELVRQYAPQIAGKIILITGVSPGSLGESFVKQVAVAQPAMFILASRSISKVQNLIDELATAYPSVKVKPLYLNLLSFDDVREAAETVNSWTDVPHIDILVNNAGIMAVPYKLTEDGYESQFQTNHLSHFLLTNLLMGKILASKTPRIVVVSSNVHRIGHIHWSDPNFNGGKHYQRWLGYSQSKTANALMGVSLAEKLGHRGLLAFPICPGVSLTNLAAHGREDLAAFSADLTDMDNIYGNKWLWGMAEMKIKDLDQGAATHVFAAFDTSIANQNGAFLSDCHAADPDMEEVHSWATSKVDAERLWRMSEKLVGQEFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF30</accession>
    <name>B0YF30_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_101380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF30"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101380"/>
    <dbReference type="HOGENOM" id="CLU_1474843_0_0_1"/>
    <dbReference type="OrthoDB" id="10633744at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="183" mass="19835" checksum="2F56A68C0ED4A67A" modified="2008-04-08" version="1">MHVSCKSGSSNPWISIRSWDPRFDTYELASPFVFAHTNQDRPVLEKGGLLAAIEEGGPVLNWPLADNEIMEAKPMLSTNPRKSTAESLRSGSGPATATGSKVGKNSTHLPSFLRPKNDDFFRGPPTILRLISYLLKPIVIVANDDIGEAAGGQAEAEVDQQAMGVVSPLSSLGRVRTKVLRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF75</accession>
    <name>B0YF75_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_101810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101810"/>
    <dbReference type="HOGENOM" id="CLU_008719_1_3_1"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="PhylomeDB" id="B0YF75"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="490" mass="54706" checksum="6CD874B140461886" modified="2008-04-08" version="1">MGKLRSKDGCLTCRKRHVKCDQVRPVCSQCQKKNRPCLREDPPSRIRIKHYQPRTAREDSKDAPGNGPEQISHVLDQATADPVIANAASHEQIIRPPYAESCNDQYPTALVTSPYSTQTQTSTILPKLANESVPMPLVTSPGSIHAGTPLTHREAYLVHHFATHLGYWLDCTDASRQFTRKIPILVKQSPILLHAVLSYAARHVGDAELAEQAHERCVELLIPSLSSEKVADDDILLCAIVILRVFEQLNVMVTGSDQERHLAGCSALLRASQGREVDPSTPGLRQAAFWVYLRQCLYNACIHQQAPNVDLVNLVLLAPPQGGGDPLSDLRSETAWANTMTWICATVVHFCFGSSYPEPATRLLRWQQLSEAVESWLSNRPDTFNPIWYSEAVPGSGNPFPEIWFTADWHIMAFGFYHLACMLLAIYKPSPRFAVRGLHSTAHPSHDARSRYLWGMQQLPFDGAIIDHALSFHLYMGSLDDRSSGKERGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMT9</accession>
    <name>B0XMT9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipin Smp2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_014140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014140"/>
    <dbReference type="HOGENOM" id="CLU_002546_3_0_1"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="PhylomeDB" id="B0XMT9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="447"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="651"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="654"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="765" mass="83964" checksum="403C5A7821C16C2A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMZ8</accession>
    <name>B0XMZ8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vacuolar protein sorting-associated protein VTA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_003870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMZ8"/>
    <dbReference type="HOGENOM" id="CLU_030378_0_0_1"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="PhylomeDB" id="B0XMZ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="38518" checksum="431B3A8F780D53E4" modified="2008-04-08" version="1">MLTCYGPKFRNENSDNDTVIDAVAANAYVEQFGLEVFNRADTTMRANKVTRQTADTFQAAATFLELCQIWNPLEPEIAAKIKFAKYHALRIVKAIKAGEDPNATNPVIKEDHQVEGPAVTVEDLEAQPGAALASQTRQPTVEEVPDESEHAARAMVQQSLMDDSLHPSRSSSATRPQRTGDAFSIPDVPTSAPRTPAPETGHAAEQGSTLELPSAPATIASSSIPNLPDKSASLGAHHPADPNSNSFHSFPPPANLPSPPAAFNQPSHFYNQPKPSAWAPSPPAQPHTEPAPVVSRPVQQPASAAVPTVSASSRSNSQGIDDQAIALAQKHARWAVSALTFDDVDTAIKELRNSLKYLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNP3</accession>
    <name>B0XNP3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_004990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004990"/>
    <dbReference type="HOGENOM" id="CLU_002173_5_1_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="PhylomeDB" id="B0XNP3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="855"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1201" mass="133899" checksum="6631D457D9867F16" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPF7</accession>
    <name>B0XPF7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_006320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006320"/>
    <dbReference type="HOGENOM" id="CLU_011638_0_0_1"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="PhylomeDB" id="B0XPF7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="50"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="376"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="475"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="748"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="653"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="794"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="843"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP55930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="998" mass="110417" checksum="F36A831F2AB8D969" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPS4</accession>
    <name>B0XPS4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_007400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007400"/>
    <dbReference type="HOGENOM" id="CLU_123413_0_0_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="B0XPS4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21437" checksum="8C4313166AFCF516" modified="2008-04-08" version="1">MQRPNAVFLSQTLPQSLWLICKYQEPARNNQVTTMPSVPDAEIYPEASGPAKALVDRHQAEQPLKLHAGWFCSLVPTLACPTGQSDGNDLKLKSFILEYYEEAYPDHQPRLLPGDPYEKARAKVWMDFVTTWVIPALHCFLQYQPQSKDEDVATETDKVRQEFLARLKESTKEMHPGGPTFLGESDFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPU3</accession>
    <name>B0XPU3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA-like thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_007590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007590"/>
    <dbReference type="HOGENOM" id="CLU_069253_0_1_1"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="PhylomeDB" id="B0XPU3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="238" mass="26298" checksum="84B984922FA4E459" modified="2008-04-08" version="1">MTNINIQIISDTVCPWCYVGYRRLSRAITAHKAIYPSDTFTLTWHAFYLNPASPGYPGVDKREYYASKFGEGRAAAIFSRLAAAEEPDGIAFKFGGRTGNTRDSHRVLWYAGLKEKEAGARGGAAATNGDASEEKVGGLQTRVAEQFFRAYFEEEKNITDRKMLVDSAAAAGLDRGEVEKFLESGDEGGKDVDLEAERARHRLVTGVPYFTVQGQYAIEGADEPETFLEVFEKVKQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPW0</accession>
    <name>B0XPW0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_007760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007760"/>
    <dbReference type="HOGENOM" id="CLU_1377804_0_0_1"/>
    <dbReference type="OrthoDB" id="4174291at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone" evidence="9">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="198" mass="22108" checksum="602B67E75CD81340" modified="2008-04-08" version="1">MCFWFPLRSSCCYHSITTIISILALYTVLKVLLHFPPKLPFGNLLAIASSCFKRTHFCYLLLLISVLRDTSKRATMGDNHQATLSNDPAANAPDAAAADKGKGKAADEPSLEMSMDEEEDSDESEAEEMPNHSTDDDDDDHDNLEPISEANIISGGRRTRGKTIDFQEAAEKLKAEDEMDDEDDDDEEFQPNDEDMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ90</accession>
    <name>B0XQ90_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_009130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009130"/>
    <dbReference type="HOGENOM" id="CLU_099529_3_0_1"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ90"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="217" mass="24001" checksum="F765D63DE66634C6" modified="2008-04-08" version="1">MATTSFRDSVNSLGWSRRDADLPARTNTSSTPFLSKLQSLNPFGQGEGYLRLPTHEAPGAPLPAPTRREEEEGFFALSRWDRMLIFIACNLGAAVCFMICFFLFPVLSLKPRKFAILWSVGSLLFLLSWAVLMGPLVYAKHLVSGSRLPFTAAYFGSIAMTLYFAIGLHSTLLTLISSIFQLAALAWYLVSYFPMGSTGLQFMGRFGAQRVGAWMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQJ8</accession>
    <name>B0XQJ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_010210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="B0XQJ8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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    <dbReference type="GO" id="GO:0030246">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
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    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase family 92"/>
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    </dbReference>
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    <dbReference type="Gene3D" id="1.20.1050.60">
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        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
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        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
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        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
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        <property type="entry name" value="GH92_N"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
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        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
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            <end position="839"/>
        </location>
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        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="768"/>
        </location>
    </feature>
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        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
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        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="839" mass="92750" checksum="F323CDE5CF280C5F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQR7</accession>
    <name>B0XQR7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_010910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_096872_1_0_1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.20:FF:000015">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="187" mass="20488" checksum="C4FECF388085FD13" modified="2008-04-08" version="1">MALSSTANHCVRFRSQLTLGLLSVSNSSKGYIIPAFLTSFKAVPLVPTACRSCDPGYPLALDAEFVGTGNDYIHADPDNKHLRLNAHGVIKTKDEAVCHDLTCNQQLLYMNYTGVVTMGPAEQAVFSGNAEDGATPFGNSFTHFTFETGDERYKEFENRVFVGQGRFRVEKGKPVVVEYKVSQVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRJ2</accession>
    <name>B0XRJ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARS binding protein Abp2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002660"/>
    <dbReference type="HOGENOM" id="CLU_009887_1_0_1"/>
    <dbReference type="OrthoDB" id="2104370at2759"/>
    <dbReference type="PhylomeDB" id="B0XRJ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048:SF1">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="780" mass="85290" checksum="F0DE287B6E44799F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRL3</accession>
    <name>B0XRL3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_013080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013080"/>
    <dbReference type="HOGENOM" id="CLU_011037_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="4">
        <location>
            <begin position="411"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="701" mass="75305" checksum="4BF43D5C2138588C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS83</accession>
    <name>B0XS83_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_026280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026280"/>
    <dbReference type="HOGENOM" id="CLU_043434_0_0_1"/>
    <dbReference type="OrthoDB" id="2935572at2759"/>
    <dbReference type="PhylomeDB" id="B0XS83"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12261">
        <property type="entry name" value="RRM1_3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF14">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="338" mass="37104" checksum="09C866C085B3A8BB" modified="2008-04-08" version="1">MEAFILGPLLRKGHIILVYGANLPSLSPKVSGELYEQQDYDGLEIRPVTQFKSSNNHGNASCEVGENYEDDPEDDGIVSPNSDEKDDFDESRSADSESSPAGQRTVFIRGLPDRATHQDVVDAVRGGALLHLYLRARDHAAYVSFVEPAAAAEFLQHAKTLGCHISGKRVEVSWNDRQFYLPPYVGSKIRNGATRNLVIHNVNSNITESIIRRDLDHIHNLIVITVKFKQGNAYISTNSVHNALFARSCMMSRGAYRGMRIGFYPDECAGLLSKLPSGPKREVQPSSIRSLSASNRFRLLSLDGSGDDDAENQETLPGALGTQYLNSSINIVASRVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSA3</accession>
    <name>B0XSA3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-tubulin suppressor protein Aats1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_026480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026480"/>
    <dbReference type="HOGENOM" id="CLU_005210_0_0_1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="PhylomeDB" id="B0XSA3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF70">
        <property type="entry name" value="SECRETION-REGULATING GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="185"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="377" mass="39724" checksum="80AC335313F5DFE0" modified="2008-04-08" version="1">MSLFAFGSNGSGQLGIGHDEDVSVPTRCLFEEGQTPSEEENGTQAKTISCIVAGGNHTLILYQDGSVYAAGCNEDGRCGHHPATASLQKFRQVIVKSRDGTCYHTFKHLSATWEGTFLVVGSEDPSAEADSIFVIGSGAKGELGLGQGCTKAVEPTRIPNFPPQGTKVVSIASGMGHTVVVLSNGEVYGWGGARKGQLGESARGMKIVWCPTKVEGIPFQAKGAVCGREFTVVSGNKSAGEYAIIGSCDNKWNILSDAPASQSLTYYRGIAASWHGVYVHQNDFSVIAWGRNDRGQLPPPDLPRSQKLAVGSEHVLALLDEHTVVAFGWGEHGNCGPDIDVQGNVNGTYKPVPLEMLQGSNVVGIGAGCATSWIITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSB1</accession>
    <name>B0XSB1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_026560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026560"/>
    <dbReference type="HOGENOM" id="CLU_2811885_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="67" mass="7470" checksum="1B7066F8B1BC32E0" modified="2008-04-08" version="1">MSPWSHKAEPTAQHTFFLGVVCMISSGAAQGVTLSNVLSSHPRFNIRNRRLRIDYAGSNVWTLQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSB2</accession>
    <name>B0XSB2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_026570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026570"/>
    <dbReference type="HOGENOM" id="CLU_014304_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="B0XSB2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="773" mass="87619" checksum="452D01B6FD2111C0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSH3</accession>
    <name>B0XSH3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_027190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSH3"/>
    <dbReference type="SMR" id="B0XSH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027190"/>
    <dbReference type="HOGENOM" id="CLU_027694_3_1_1"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="PhylomeDB" id="B0XSH3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="524" mass="57663" checksum="C628F5A64E28964B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSZ4</accession>
    <name>B0XSZ4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_028320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028320"/>
    <dbReference type="HOGENOM" id="CLU_103404_0_0_1"/>
    <dbReference type="OrthoDB" id="5308323at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757859" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19585" checksum="8AF20E3DED514DF4" modified="2008-04-08" version="1">MRFLTSITPLVSLLPLIHALPSPTSCTTVTPDIARVSEADPVASYLPGFRISQQAGGTNKEDMFVEFNITAGSWGCSLSSFFPAGTPVTTSGAAAPVEIFAVNGPLSRSPHGIDVSWAYCPAPGALVGSTAFESDPNEARTRFVNSFSCTDKMTYRLSIASWYKQAASVEFAQGPGVGLRMTHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTB4</accession>
    <name>B0XTB4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xylosidase: arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_028830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028830"/>
    <dbReference type="HOGENOM" id="CLU_016508_3_0_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="B0XTB4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="330"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="558" mass="62168" checksum="9F3788CFD5401663" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTC9</accession>
    <name>B0XTC9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_028970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028970"/>
    <dbReference type="HOGENOM" id="CLU_091441_1_1_1"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="PhylomeDB" id="B0XTC9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="156" mass="17770" checksum="B7B36CB2BDFEA962" modified="2008-04-08" version="1">MRDAESALRKLSRNLHALTAQHEEAVSSHDSAKHAAQMVELDTKKFRIAKAATELEIESERLEGELEMLKERLAELEAQGLEGDEATRREREADDATILRLKIYRSLGIDIEADEAGNFSKAVIRNSRKGDVHVVNMDPKFSRFFYANYFWSTMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTI5</accession>
    <name>B0XTI5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSF1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_018700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018700"/>
    <dbReference type="HOGENOM" id="CLU_067902_0_0_1"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="PhylomeDB" id="B0XTI5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="272" mass="30787" checksum="C72CF157BDD4EF9F" modified="2008-04-08" version="1">MKFFENVFTYDYSFPAVSLAYFLRYPNPYSRHVLTTDVIDRYVDPKTERLHTVRLHLKKSKVPSGILKLLPKGIGGSDNSGQSYILETTVVDIKEGWMETESRNMEWTGILSVVEKQLYTRQPIEGSLESLQGLSLDAQRNEQTQVKTTVTFRSRLGQGKFLGKKKTIPTADQTIEFDEETPKKGFFSSLSTAGIQRTIELIGVSRTRDAVLKSKEGMNVVLERLRNGGIVGVLEGMRQDREAAFGPDGPWKRVWLRGNGLKDRAFTDDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTL4</accession>
    <name>B0XTL4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_019010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019010"/>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="PhylomeDB" id="B0XTL4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="110"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="429"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="546"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP53855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="664" mass="74281" checksum="7881756C245C9EC9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTL8</accession>
    <name>B0XTL8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_019050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019050"/>
    <dbReference type="HOGENOM" id="CLU_042683_0_0_1"/>
    <dbReference type="OrthoDB" id="5389296at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="470" mass="51416" checksum="3E9A248F9224CE06" modified="2008-04-08" version="1">MQQRMALFSEECSNNARLDALNFPDLTSCRVPSSEGPLTKANDEISTSDTEESPRSTPLSTARVAPQQRGRELIEDFQDDATHLFDSGLRKAVDEISDSETNHSSPPEGASDAEAAFDALFEPTTVDRRKRRRISLDEEPSTARPARHSADMILTSSPETSALMADPPSSPIPFRTPKTKPPTAASLRTVPAVQQTPRPATPVSTAPFRDHPRFKMFQPALSSQSQFTPRPTAGSASQLPTPGPQRQKPVFVLPRSPSPSRMDDESIIPTPFSPSSHALRRRGRPRSSTADYLPGGMASDVRSWILEMGTKSEQMQKSLDAHSSAHYAQGPPDLSQYYLVLRILDVRQSALGSSGPVAYIHGVEVTLPDESESATSQSRRVLLLGPPRPASLQSSRARAQVPELRTGHLVGVFRNLVWEVGLDQTHLDGNVPSEDTQKKEEPASSLGRDTSTEHLEKWLVGAEWELIDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTQ7</accession>
    <name>B0XTQ7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_029590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029590"/>
    <dbReference type="HOGENOM" id="CLU_046747_1_0_1"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="PhylomeDB" id="B0XTQ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="433" mass="49062" checksum="DE6AFD7DD8AE9DAA" modified="2008-04-08" version="1">MSRSTDRSATGDCPSLPWRALSATTIFGVAALCRSFLYMCSRPEINGLESFLELLESRQDVSRRTRGLLTGIDPLYSTEFPCFCLIAWRTSIADMGLIRQYRTILACTMDDPIMWGAIPLRWNFGLSSSNKRWGFGSHDICYQSRPLALFFTMGQVLPTHRLAHSPHGGLAQPAVTQAIRLLSKGPFPPDPHLPPPERQHWSLENICVDPFSDLPTAYTTTGIDSHLAPSAYACNSYSWVHIFPEGKIHQAPNKTMRYFKWGVARLILEANECPDIVPIWLEGFDQVMHESRGFPRFLPRVGKDISITFGKKVDSEAVFGDMRRRWREIKAKAEVASPESRNLPLGVLSDELLHDEEAIELRKEVTQKVRDLVLEVRRTRGLSDEDPKHGLAETWIEEGPQREGKMKDESWSFQSRVQPCSLLQLRRGGIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTU3</accession>
    <name>B0XTU3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_029950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTU3"/>
    <dbReference type="HOGENOM" id="CLU_139257_0_0_1"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="PhylomeDB" id="B0XTU3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13962" checksum="A115B3A4685CAAC9" modified="2008-04-08" version="1">MSNRAEREAEDMYEAENDASPVSADVIDNSYVGETRSELRNQVPVQPDQDDYEDPMQPPYSNTDQQLAADEREAIDKSNILRGDRLRHAKPQTANKYNEGPDEDDLPDVVRYGDSGVSSTKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU74</accession>
    <name>B0XU74_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_030580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU74"/>
    <dbReference type="HOGENOM" id="CLU_029381_1_0_1"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="PhylomeDB" id="B0XU74"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="42"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="367" mass="39716" checksum="F4946D23B6B93F3F" modified="2008-04-08" version="1">MGPMAGSVVGRVPAQQNSTCEVSSLQCSGRHEELIRKNTQGDTMTKPTPSMLEAICQTTLLDDVFEEDPVTNDLQAYVAERTGHQSALLVMSGTMGNQVAIRTHLVQPPYSVLCDHRSHIVRYEAGGVSSLTGAMVQPIVPSNGIHLTLEDIQKHAVLDEDVHYCPTKLISLENTLDGMVMPLAEARRITEWAHQNGVKVHLDGARLWEAVVSGAGSLPEYAGLFDSVSLCFSKGLGAPIGSIIVGSTEFIKKARWFRKSIGGGVRQAGVIAAAARVALEETFGPDPNGQKGKLRETHINAKRVAEMWTTRGGKLQHPVHTNMVWLNLESSGVGPNDLAEIGKELGLKLLGGRIVVHYHWGRFLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUA4</accession>
    <name>B0XUA4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein-ER retention receptor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_020040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020040"/>
    <dbReference type="HOGENOM" id="CLU_041571_0_0_1"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="PhylomeDB" id="B0XUA4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP53958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="337" mass="39151" checksum="828ADA9421FA2DDF" modified="2008-04-08" version="1">MSMNVFRLLGDLSHISSKCILMWAIHRNKSAEGVSLLTQMLYAVVFVTRYLDLFRGSGWRSIYLVFFKFFYILSSFYIIFLMMKVYPRTRERERAWKMALGSVVLSLVLAPIVTPILDDKEFFKIHWFTETMWSFSIILESVCVLPQLLLLRQTTVPTVIDSYYLLALGSYRAFYILNWFVRGFGPEKHWDPIAMIFGIVQTAFYVDFAWVYYSRQRVKLRNGGVVDSEDYSKSWIVNKVFNIRRRRESLDEEQNLTGEGMEGERGDGGDRPRNNRWGARGISISADDMLDEHTRRKPGDADNEGLEGFLEDEDNSMDDQTGGRSPLHHTSVTSNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUA7</accession>
    <name>B0XUA7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_020070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020070"/>
    <dbReference type="HOGENOM" id="CLU_091071_0_0_1"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="PhylomeDB" id="B0XUA7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP53961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="191" mass="21532" checksum="3D0233B35B978075" modified="2008-04-08" version="1">MFLQRTAFALARRAPVRAVAARPFSSSVVRCQKKYEVKKEGKILPFEEIKTEEDLIAPGAKPGTVPTDVEQATGLERLELIGKMQGIDIFDMRPLDASRKGTLDNPIIVKSAGDEQYAGCTGYPADSHHTVWLTVSRDRPIERCGECGNVVKLEYIGPDEDPHAHEHHSHHPPHEEPKTFADYVKPEYWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUV8</accession>
    <name>B0XUV8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_031600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031600"/>
    <dbReference type="HOGENOM" id="CLU_3031936_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="55" mass="5987" checksum="EB6F2833FFA2539E" modified="2008-04-08" version="1">MEAKTRTSEVKSTTTSRGQKTQTLIVYGVDIGVLRQVALTPLSPLAHLTSLYPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV08</accession>
    <name>B0XV08_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_021240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021240"/>
    <dbReference type="HOGENOM" id="CLU_025004_1_0_1"/>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="PhylomeDB" id="B0XV08"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="82"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="64482" checksum="DB817B4C81FBF227" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV59</accession>
    <name>B0XV59_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin C-terminal hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_021750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
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                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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                <person name="Anderson M.J."/>
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                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
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                <person name="Sundaram J.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EDP54215.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="105" mass="12042" checksum="27BE0B8F55A5135C" modified="2008-04-08" version="1">MERQNNRRQENGEQRQDPNAQPSQQLELEAAFPQSQPQNGRIEDTEYYTNFLEQLLGLVRHGDQESVSRMISVIRSGASQEEILKTLSEISTNIRNGQEGNRGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW89</accession>
    <name>B0XW89_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_023970</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0XW89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023970"/>
    <dbReference type="HOGENOM" id="CLU_001832_1_3_1"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="PhylomeDB" id="B0XW89"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="670"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="919"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="229"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1455" mass="163844" checksum="9E08923450A3E0A8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWQ5</accession>
    <name>B0XWQ5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_046950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046950"/>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_1"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="PhylomeDB" id="B0XWQ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="64"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="387" mass="42065" checksum="E908AD8BD08BC502" modified="2008-04-08" version="1">MASLRPSVKRLLRQPPCRLYSGAPSSSSRLNLPIDYKSTPLLHHTSSSLSSALELPGSTTSKSLNLYQAINSALRTALATDNRVMLFGEDVAFGGVFRCSMDLQTEFGSERVFNTPLTEQGIVGFAIGAAAQGMKPVAEIQFADYVFPAFDQIVNEAAKFRYREGGTGVNVGGMVVRMPCGAVGHGALYHTQSPEALFAHVPGVQVVMPRSPSQAKGLLLSAILQSNNPVIFMEPKILYRAAVEHVPNEFYTLPLNKAEVVKPGNDVTVVSYGQPMYLCSEAIKAIEKDMGASVELIDLRTIYPWDRQTVLDSVKKTGRAIVVHESMINYGVGAEVAATIQDGAFLRLEAPVKRVAGWSTHTGLTFEKLILPDVARIYDAIKQTLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWS7</accession>
    <name>B0XWS7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_047170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047170"/>
    <dbReference type="HOGENOM" id="CLU_070319_0_0_1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="PhylomeDB" id="B0XWS7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF22">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="36"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="253" mass="27473" checksum="0447229817B5FB1E" modified="2008-04-08" version="1">MTGKKILIILTDAKSFPLKKTSGPDAGKTVEQPSGFFLMELAKPLEKILAAGYEVTFASPKGLEPTPDPLSESLAAFAGNFYERRRENDLIDRMKRENGFSRPRPLGTISDAELDSFAGVFIPGGHAPLSDLGSDKEVGRVLRHFHAKKKPTASICHGPIAFLSTKQAGDGSFIYKGYKITCWSDAEEKVMETMFGGEVKKVESSLRNEGAEMVEGPREKVGNITVDRELVTGGNPLAANALGDQFLKMLSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWT8</accession>
    <name>B0XWT8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved glutamic acid-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_036380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036380"/>
    <dbReference type="HOGENOM" id="CLU_116801_1_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="151" mass="16639" checksum="55B59E0605FDE645" modified="2008-04-08" version="1">MSTRKRKQEAEEEEELQALPSDESEEEEEYEDSEVGESEEEGSEEEEEFEEDEGEGEEEEEEEEEPSKDKAPPSKRRKTAPEGEAKENGNGVPAKDEDEEEEEEEDGEGEPEDEEPADTAKTSTPAAAATKAKGSAGPAEAEVEVGEENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX94</accession>
    <name>B0XX94_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrodipicolinate synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_037270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037270"/>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="PhylomeDB" id="B0XX94"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="335" mass="35961" checksum="F33635944E7DBF3F" modified="2008-04-08" version="1">MSSRTPLRPGVYAPTMTFFNPDTEDLDVPTIRRHAVRLARAGLVGLVTMGSNGEAVHLTREERKTVIRETRSALDDAGFANVPVIAGASENSIRGTIELCKECADAGAEYVLIVPPSYYRYAVGNDETLYEYFTAVADGSPLPVILYNYPGAVAGIDMDSDLIIRISQHPNIVGTKFTCANTGKLTRVAGALNAITPPSPLAPTTKRASTKPVENHPYVAFGGIADFTLQTLVSGGSAILAGGANVIPRLCVRIFTLWSEGRLTEAMEAQQLLSKADWVLTKAAIPGTKSAIQSYYGYGGYPRRPLARLSEEQAQAVAEKIKDAMEVEQSLPDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXB6</accession>
    <name>B0XXB6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_037490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037490"/>
    <dbReference type="HOGENOM" id="CLU_018461_0_0_1"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="PhylomeDB" id="B0XXB6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="47"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="649" mass="71834" checksum="8815D55A844D5477" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXF9</accession>
    <name>B0XXF9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_048190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048190"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B0XXF9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="406" mass="45587" checksum="9920D30BD5FC7F32" modified="2008-04-08" version="1">MPRIDTVAIIGAGPSGLALALALHKQSIACTLYEARASALDIGGAMMLCPNGLRILDSLGVYSRIRPEGYEFDKLYFRSPDDQPMDTYEFGGVEQYGYRAMRIYRHVLIRELSAMVREAGIPIEYHKKFVRVLAETEKDITWEFSDGSTATATCVVGADGIHSRVRHYLYPGLEPSFTKMVIVAAAVPTSQLQVPSSYNLPVTILNQQHGAVFIAPQLGDGSEVMVGRQKRSEQLTREGWDELLNNNKEWCMDFLRQGSDDFPEIVQRAVSNITPEKIFLWPLFIVPKLGTWTSRHGRVVIVGDAAHAIPPAAGQGVNQAFEDVFTYSLMLGRSDKDALARSLKVWQTRRQERIDKVLALNTYMERRRVPSLEEEKDAEDAPLDFASLYKPDFVEIVDTWLSKHTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXW5</accession>
    <name>B0XXW5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_038800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP52711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_002935_0_0_1"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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        </location>
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            <begin position="1103"/>
            <end position="1124"/>
        </location>
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            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <end position="73"/>
        </location>
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    </feature>
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            <end position="109"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <end position="140"/>
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        </location>
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            <end position="363"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1153" mass="127995" checksum="0367261E07DCAEE3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY04</accession>
    <name>B0XY04_ASPFC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AFUB_039190</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
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                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="104" mass="11842" checksum="078FB48C5A12EB84" modified="2008-04-08" version="1">MQSLIPLFILLVAIIIFSVIAYIAYSIVQEVGKNTRSKMEKKNVMFTRDGVKVGVKELTEEDYVDRSQSILVNIWNHTSFPAYKSRLWNMTGSTAGAETEKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY48</accession>
    <name>B0XY48_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">AFUB_039630</name>
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    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="p-nitrophenol monooxygenase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="388" mass="43545" checksum="6A692A0A4CA47D28" modified="2008-04-08" version="1">MLSRQAIPVTVLEAAEQLDTRPRATHYGSPAVYELRRAGVLPDVLAEGFTPGVICWRKLYGTYLAGIDNRIMANDPDQVACLPLGRLGQILLDHLARQPSAEIKWNHRVTGLGQDPDQAWVTVATPTGEVTMQATYIVGCDGANSQIRRSLFGDGVFPGKTWDEQIVATNVYYDFHQFGYEDANFIIHPEHWYMASRITKDGLWRVSYGEKGGLTHEQLAERQPKKFQAMLPGHPTPDQYRLVNFSPYRVHQRLAEKMRVGRFLLAADAAHLCNPFGGLGLTGGIADVGGLYDCLYGLYTGRATPDILDMYDRVRRKKYLEVIDKLSSDNLRRMFETDPDTVIESGSDELFNLCLKAEKDVELAKQLVTGINVIKYDFTQHYSEAGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYH4</accession>
    <name>B0XYH4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_040930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYH4"/>
    <dbReference type="SMR" id="B0XYH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040930"/>
    <dbReference type="HOGENOM" id="CLU_079690_4_0_1"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="PhylomeDB" id="B0XYH4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="242" mass="26484" checksum="8564292D12D8DD54" modified="2008-04-08" version="1">MHQLSTSICLCFVISSPYVYLVSIACVLWTSIPFTSGMMDHSAMHHSGMDMDHGHGDMDMGGQCNMNMLFTWSTKDLCIVFSQWHITGPFSLLMSLIVIVLLTAGYEGVRQATRKYEAAQAQRLNVFSTTTATIARLKPSLTNGVQGNEFADESATTNVPSSQTPNESSPLVAGRDNRRAVEQRGKIILAALYAVQVFYSFFIMLLFMTYNGFVMLAVAVGAFAGYLVFGDNQSAAKTVACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYI9</accession>
    <name>B0XYI9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">AFUB_041080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYI9"/>
    <dbReference type="SMR" id="B0XYI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041080"/>
    <dbReference type="HOGENOM" id="CLU_022610_2_2_1"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="PhylomeDB" id="B0XYI9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="152"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="309"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP52935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="479" mass="55196" checksum="1DBD68E70B2AE957" modified="2008-04-08" version="1">MDSMTDSSNSLRSSDLPEMFRPPVNRAMRVLDRSFFRKTVPLSAAAVFQNSDISKVRAELHKSRDLLAVPRLNCIRDVADQEGQIKKALLLRETVKHDDKETWSPKISELVEKGRIAMRPYDLTLDYDFWTYADIISSILPEDELQEIPQGFTQVGHVLHLNLREQYLPYKYLIAEILKDKNKVIRTVINKTEDVGSHSEFRTFPFELLAGDNDLNVVQHEQDCEFRFDYSRVYWNSRLETEHRRLVEKFNKGEMVCDVMAGVGPFAVPAGKKKIFVWANDLNPHGYEVMQDAIKRNKVEGFVTPFNMDGREFIRWSAKELLETEPVTVTIHPKVRRDRKSGNKVEQAPPPHPEEYHRPVFFDHYVMNLPATAIEFLDAFPGIYAGKESLFAPHTSQRLPMVHVYCFSGHSENELDDHIDICQRISERIGYTITPEDRIGGSGNQSVELSIHNVRLVSPKKQMFCASFRLPAEVAFKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYM6</accession>
    <name>B0XYM6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_041440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041440"/>
    <dbReference type="HOGENOM" id="CLU_095773_1_0_1"/>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21900" checksum="FA0FEC5A7317E681" modified="2008-04-08" version="1">MTTAKTYTRSALVQPTLALCDAFASAAPVPVLLSHFTADPLPMVHEHGLPVLAPFLGRTFTGTDGVGRYFELIADLLSFEKMSFDGEDEWIVDTVSMAVSLRGRARFTWKETGEGWNETFCYRIGLAEDQGKGGGGLKVQEYRVWADTGAAYLARTHQLGEVQREFAERETKKSMERTRSGHGNLIGEGQRVYSGGSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYQ5</accession>
    <name>B0XYQ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial metallochaperone Sco1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_041720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041720"/>
    <dbReference type="HOGENOM" id="CLU_050131_0_2_1"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="PhylomeDB" id="B0XYQ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="125"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="163"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="303" mass="34098" checksum="204B6068084931D3" modified="2008-04-08" version="1">MASSARPVSRILGRLSRSGISTVESSAHLPTQRTASLLSRSALTTPKPNGIGIRRATPQQRGFSTSPACLRAKTMGQLRARNATGPFSWKAALLFVLTGAGMIVYFRVEKERLERKRIAEMSKGVGRPKVGGPFTLTDLDGKEFTAEDLKGKYSFVYFGFTHCPDICPDELDKMAEIIDRVKEATKGENIFLPVFITCDPARDTPQVLREYLKEFHPDIIGLTGTYEQVKHVCKQYRVYFSTPKDVKPGEDYLVDHSIYFYLMDPDNDFVECIGRQDTPESASKVILQHINDWKREGKPLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZF7</accession>
    <name>B0XZF7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_044250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044250"/>
    <dbReference type="HOGENOM" id="CLU_2399259_0_0_1"/>
    <dbReference type="OrthoDB" id="4485960at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="93" mass="10686" checksum="FD5E9BCF2E61B758" modified="2008-04-08" version="1">MVLPPGTLQSDIDQKIFYPDWTLRPGWKVSFVGVSTKRGWEHKFTHKKTGGSFLDVDIIRRRDYWAQMTEDMRQEALASKLAPNMGDGGGFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y035</accession>
    <name>B0Y035_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_045490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y035"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045490"/>
    <dbReference type="HOGENOM" id="CLU_1547186_0_0_1"/>
    <dbReference type="OrthoDB" id="2103397at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="173" mass="19279" checksum="101F90BB42CBB277" modified="2008-04-08" version="1">MRSKAAIAEVPVVSRTVAQQGKRPAASENTDLPHITIADIQPQNVRRFLRLQPDPDPGSCWQLTAQDKIQGPEHLGRDGENKALMRSRLEIILVAVLASKKRESASAYGSLHLQFENSLSLPWSYLNGDYVLEGTTDYSIWYGGQKRETNLLLLCALRRGNIGRYRALSSMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y085</accession>
    <name>B0Y085_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II Elongator complex associated protein Kti12, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_035130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y085"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035130"/>
    <dbReference type="HOGENOM" id="CLU_027147_2_1_1"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="PhylomeDB" id="B0Y085"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="441" mass="48014" checksum="8D1C8ABCE480AFC9" modified="2008-04-08" version="1">MPPRIAPRRKSLRQNSHIHIHCCYPCSGLSYRAQQLASLLEVTQDELFKSGAIPASRPRYKIHIVPTHDPSHPRTVYDNARTEKEARGVAYTRAKRALGRDSFVILDGMNYIKGYRYQLWCEAKALGTTSCVVHVGTPVDQCVANNEARIRRRNTQQEKSESHDNEPKEASTINADPEVEAQNTTQTDAPSPATDDTEEPYPPDLLKNLIFRYEEPSTYSRWDKPLFTVLWSDPEPPIAEIWTALTGIPHPSTSTEPETPVTSLTSVLASSALLSDTASINTSATARTPRTAALHRPKIKPHQATVQPTATDSSALYAMEKCTSAIVSAIRSYALTNPSAEAALAQNPDARGIAIPVPEASSPIFIPAHVATSGTTDELAGAGGILALPRLQRLRRQWIGLNRAYVGVNHASAVKGGLAPDQVGDAFVRFLNAEFAGESGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0F4</accession>
    <name>B0Y0F4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromatin remodeling complex subunit (Arp9), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_045990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045990"/>
    <dbReference type="HOGENOM" id="CLU_015497_0_0_1"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0F4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000236">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp9), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="687" mass="73338" checksum="2A03AF49D7C9D683" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0Q1</accession>
    <name>B0Y0Q1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,2-mannosidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_058120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0Q1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058120"/>
    <dbReference type="HOGENOM" id="CLU_976531_0_0_1"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0Q1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000005">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF38">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="1">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="285" mass="31990" checksum="66D5C3428097CE3C" modified="2008-04-08" version="1">MHLIPTNQTGENPSWTSSEPYYQDIFTYWDLFRCSTALMQVLQPTAYEEQIRSLIDIWRFEGYLPDARSSNYNGRTQGGSNADNILADAYVKGVRGAVNWEDGYKALVQDAEVAPPNDPIDPMAPDSSTKEGRGALPDWLALGFITPKYTRAVTRAVEYACNDFAVYQVASGLQKQADAEKYLNRSRNWRNHWNPEQTSLGFSGFVVPRSTSGFLETDPLADSGYWGDPYYEASSWAYSWASVHDMKEMVERMGGEQTVVDRLNTMFTEGASGSNGMIFDPTNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0W5</accession>
    <name>B0Y0W5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_058770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058770"/>
    <dbReference type="HOGENOM" id="CLU_087056_0_1_1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0W5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="120" mass="13186" checksum="505436BD106EB57F" modified="2008-04-08" version="1">MQDLADELPESSPRFILLSYPLTLVGGICAGGSDAPPLKSCSKNVRVLETNFFSSHQGSGRLTVPYVLLYYLPENCNPSMRMTYAGAVELMRNTAEVNRVIEVQDEDDILSIESKLQGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1J7</accession>
    <name>B0Y1J7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_049540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1J7"/>
    <dbReference type="HOGENOM" id="CLU_764996_0_0_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1J7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41151" checksum="D51CA466403869C3" modified="2008-04-08" version="1">MLSVALRIAQALSLHMTDPPFPVTPFEREMRRRLWHVIGWLDLEASLNRGSESMMRSAWIQTHSLTNINDDDFGCDSEDPLPAAQRGPTEATLLILFAHGQCALRALDLSHFAEPGITDIQERQQTVDHFRRTTKELLAGCDPENVPFHWFSIQIQEQISAVLQLIALRPLQRSPTFVPAELPAPQMLALAADILERRQRIFNDPQGQPWRWFGLLFFPWHALVVAMTEVCVCTDRLVMDRYWPTVERSYDLFQKQAVGTHYDWLSASMDSLMNNARAARQKVVDSDAPGLQAPDSHLYMDMASLERPLLPESLPPVPDAALAPEGLTLLPDQEISAWAQYGEFTDRFDELHAIFNSGLTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y202</accession>
    <name>B0Y202_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase (AKR), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_050440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y202"/>
    <dbReference type="SMR" id="B0Y202"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050440"/>
    <dbReference type="HOGENOM" id="CLU_023205_10_1_1"/>
    <dbReference type="OrthoDB" id="5357513at2759"/>
    <dbReference type="PhylomeDB" id="B0Y202"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000045">
        <property type="entry name" value="Aldo-keto reductase (AKR), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF8">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="318" mass="35505" checksum="80304F5BDED838FE" modified="2008-04-08" version="1">MARAAISKMPWDKYILRSVQEAPPVHLPLFLYGTAWKKDRTAGLVYQALNAGFRAVDTAGQPKHYQEELVGEGIRRAIHDGILRREDLYTKFTSVHGQDPNKMPYDPRTSVTDQVHASVKSSLHNLCAPDASSSVEDAYIDTFLLHSPLSTMAETMEAWLTLESYVPHRIRNLGISNCTLPILKELYARATVKPAVVQNRFYPDTRFDVPLRTFCGAHDIIYQSFWTLTANPGLLRSDAVQSLASQVEISPAAALYCLVLGLGNTTVLNGTTNRARMDADLAAVRKVEQFSKDSPDAWQMVLDHFKRVIGDDVDTVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2K7</accession>
    <name>B0Y2K7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_062170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2K7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062170"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2K7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000524">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="544" mass="58998" checksum="E097BAA933D5DD05" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2L8</accession>
    <name>B0Y2L8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxypeptidase Y, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_062280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2L8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062280"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2L8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000003">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF432">
        <property type="entry name" value="Y, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760387" evidence="6">
        <location>
            <begin position="18"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="472" mass="52420" checksum="4DBDCC3EFA3D4EC6" modified="2008-04-08" version="1">MIVSYLLHFALYTVAYATQEVLRPVTDQDSEFRIVQSHHSPDHSIRIKQQNESICAAGSPQYTGWLAVGHKHLFFWYFESQNDPSHDPLTLWMSGGPGVSSMVGLFQEIGPCLVDEYGNGTYHNPWGWSRYSSLLFVDQPVDVGFSYVDGGHELPRDSKEAAVDMHRFLQLFVSEVFPHLQDLPVHVSGESFAPQVRLKSCLVGNEFMSPRDTFFGYWETLCTTNPGVEKPVFNQTRCDLIASNMPRCMEVSAVCVQNPDPALCSAALSVCYEGVVGLYEDESGKGGRNRFDITAPCEIDDMCYIQAVHVEQYLNTPAVWNALSPPKQISEYKMVSEAVIDAFAKSSDGMTSTSDLVAFLLANQVHFLAYQGNLDLACNTAGNLRWAHSLVWKGQAEFASKPLRPWRSPVAATGRNETVGTMKEVRVRVGNADTESRFALVTVDGAGHLLPQDRPDVALDMMVRWITGAPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2S9</accession>
    <name>B0Y2S9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_051850</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2S9"/>
    <dbReference type="SMR" id="B0Y2S9"/>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2S9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="349"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="565"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP51181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="830" mass="93718" checksum="1EBCC5ADDD317253" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y306</accession>
    <name>B0Y306_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_052510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y306"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052510"/>
    <dbReference type="HOGENOM" id="CLU_184680_1_0_1"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="PhylomeDB" id="B0Y306"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP51247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="89" mass="10378" checksum="C5D30B3EFECDDB3A" modified="2008-04-08" version="1">MHLMYVLDKDGKRVYTLKKVLNGEVTKSAHPARFSPDDKYSRHRVTLKRRYGLLLTQQPGTSLSLNRRHLQETNKLNSEDERGAVIRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y355</accession>
    <name>B0Y355_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleolar RNAse III, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_053000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y355"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053000"/>
    <dbReference type="HOGENOM" id="CLU_048162_1_0_1"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="PhylomeDB" id="B0Y355"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="149"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="373" mass="41489" checksum="67355E4B97AAF19F" modified="2008-04-08" version="1">MVLKRKSVFDPPVDGSSRKTKSRAASKDPSQEADQSSLACCIGRDAQEAPFDGERSLTRDRRSRLRLLKSLTQELVDSIDLLRDHAGHDVTDAIIELDKAFRCAKAPLSPISRPDNNSVEFARTQENGNSLSLPELPPILDSSLELAVFTHPGLSKDSKLTYDRLEILGDAYIELIATRFIWGRYEGFSSGQISQIRELLVKNETLSEFATLYGLDNRASVPRDLLSQPRRWTKTKGDIFESYVAAVILSRPSDGYHVAERWLTRLWLPRLTDAVIPRTALDAKETLAKRIMGKGVKLKYVDERSPAQSRGGMQTFYVGVYLTGWGWQNKHLGSGHGPSKAVAGDAAARQALLNEPLISSISQKKKNHESTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3A0</accession>
    <name>B0Y3A0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_053450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3A0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053450"/>
    <dbReference type="HOGENOM" id="CLU_021000_0_0_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3A0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001559">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP51341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="633" mass="69217" checksum="5F1DD7AAA7348CD0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3A4</accession>
    <name>B0Y3A4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAR adaptor protein RVS161, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_053490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3A4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053490"/>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3A4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="261" mass="30174" checksum="A4FC55901CC8699B" modified="2008-04-08" version="1">MSWAGFKKNVNRATTQVMMKTGHVERTNDRDYEIEERRYRTMEAAANRLQKEAKGYLDSLRAMTASQMRIAETIDAFYGEAGTRDGVSRSYKQAVEDLDAETIKALDGPYRTTVLDPISRFCAYFPDINECIKKRNHKLLDYDAMRAKVKKLVEKPDKDATKLPRAEKETEMAKQAYEQLNEQLFTELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDAETRDQYARGDLDNRVEEVLQEIRDLSIAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3A8</accession>
    <name>B0Y3A8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AT DNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_053530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053530"/>
    <dbReference type="HOGENOM" id="CLU_1124299_0_0_1"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="247" mass="27247" checksum="1943F0B3CA5740AD" modified="2008-04-08" version="1">MPALCLSPVFSSFGCVRLMSYLHCVEVFVKVRVNGSAWLLLIYFVPGRSLNSCQFAFHTMCQEQQQQQQQQQLQQPQMSVPVNPGLVPFPPPRHELSAPTAVRPEASHMRKRPLFLLDKQPLAPRAIQPRPAASTASYSSESSASALLSPSLESTTTKGEPPRKRGRPSKAEAERRKAAAEARGEAYPPPRSQPARRYVFRNFVYTSGGSPAPGSPKSGATLCTPSWEASHTHGTYRRWTSKRGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3H3</accession>
    <name>B0Y3H3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YggU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_054200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3H3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054200"/>
    <dbReference type="HOGENOM" id="CLU_130694_1_0_1"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3H3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="133" mass="14502" checksum="D2D70FA801ED9913" modified="2008-04-08" version="1">MSSRTPPLLRLIENITTSSRNKPQNLPKKYSLQIACHVKPNASSSREGIIAVGAEKVDVCVAAVPRNGEANTAVSRVFAQIFDVPKSNVEVIRGLKSRDKTLCITNLDIGKDGEDQFLKGARQRLEEAIISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y427</accession>
    <name>B0Y427_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_056290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y427"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056290"/>
    <dbReference type="HOGENOM" id="CLU_1695071_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="155" mass="16985" checksum="17479C072CBEA9DF" modified="2008-04-08" version="1">MDENDLCTLAPIRPWPSPESVIQTWLDRSHITSNNCIDAGIIQGSVLTLFGPGDPPHKLPLILTVAATGQVTLSAVGTFVSFGQHFIIGLMVAPAPKSNSAVTIKRESTESSLYYSTDRIARPMFHKAENELTEYWAQAHCPRIDQSVKLSSCMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y455</accession>
    <name>B0Y455_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain and ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_056570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y455"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056570"/>
    <dbReference type="HOGENOM" id="CLU_522836_0_0_1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="PhylomeDB" id="B0Y455"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="529" mass="57658" checksum="8640D5B0E3F7CD16" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y472</accession>
    <name>B0Y472_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_056740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y472"/>
    <dbReference type="HOGENOM" id="CLU_030988_1_1_1"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="PhylomeDB" id="B0Y472"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="229" mass="25982" checksum="A931B6B7620E4AD6" modified="2008-04-08" version="1">MDMFKLRDQASEASEATNLEDYLIYSRPLNDEDIFNWNVGLIVLNPDSLYYGGYFKASMKFSKNYPYSPPEFRFLRPLYHPNIYPDGKLCISILHAPGEDEMSGELASERWSPAQRVESVLISILSLLDDAEVSSPANVDAGVMLRKDFESYKALVRKDVEQSKMDIPEGFVMPTHESSMKRPTEKPDDADFWADSEVDSDVFGGSDSDEDLDLDDQDTGSDDEEDDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y544</accession>
    <name>B0Y544_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_071340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y544"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071340"/>
    <dbReference type="HOGENOM" id="CLU_608459_0_0_1"/>
    <dbReference type="OrthoDB" id="4436136at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="514" mass="57060" checksum="C177313955A2AE7D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5J3</accession>
    <name>B0Y5J3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_063590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5J3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063590"/>
    <dbReference type="HOGENOM" id="CLU_028123_3_1_1"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5J3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF42">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="183"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="457" mass="51665" checksum="F8B558AE752F4CE5" modified="2008-04-08" version="1">MREASKQTVAVIGSGMAGLVAAFLLHRDSKGRYRVEVFEKQDQLSLDSASYTLEAATDELPHRVDIPMRAFDDNYHINLKRMYDFLGIDYVSPKFLYSLSRICPSSGKREPPYFIHSSSNHQVPPIRPRSRSRMDWIAETLYLTVCYFWFIVCCFVIGPKGKSVSCGDESFRRYLERIRLPQYFSRRYLLPLLSSMTTCSHAELLDFPAIDVVDYATRTYCQPHYTVVGGVHRVQARISDGLAIRLHSTVTAVEAAGTRCRITWIDSQNDKVSSAEYDHVIMAVTPDVVAAIFKPLERSLRSIPTVKGDCIVHCDTSILPDGGLLCTEAKKALEPPEIMYMVSDNNSTESVHIHRSSVMVTNFPIEPINSNKIIHRARLTRVLRTVRSREVVNRIFSASQSQNTLSEKEQLWRNGDGNVWLVGAWCWDGMVLLEGCIVSAMRVAACLGVDIPWSKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y624</accession>
    <name>B0Y624_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_065410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y624"/>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="PhylomeDB" id="B0Y624"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP50209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1213" mass="135810" checksum="549495772DCB51CC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6A8</accession>
    <name>B0Y6A8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_066260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066260"/>
    <dbReference type="HOGENOM" id="CLU_1440728_0_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="188" mass="19629" checksum="B4DC7D84CBB12DA3" modified="2008-04-08" version="1">MKSNGGASQAEPQPNNKQNASAQLHPSPRIPGPAVPPPDTSGLQEMSRLFRPPFLVRLLLEWGADVNAPANKHKHGGKPALQTAAPENHRVMTDLLVHQGAGVNGVPSPVRGRTALQEAASSGYVQLSEYLLAHGADADALAEHLGGVTALQGAATRGNIRIVMMLRPAGVDVHGAAAENGRLDTLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6T2</accession>
    <name>B0Y6T2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_068040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068040"/>
    <dbReference type="HOGENOM" id="CLU_2793518_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="68" mass="7996" checksum="8F45C0ADAB9B594C" modified="2008-04-08" version="1">MLRSQSQITSKKKDTARWKKARHWRADESEKMTNRRMQHSSTNFIHQRRCKVAGIEGGGGSKQRIKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6V5</accession>
    <name>B0Y6V5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_068270</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068270"/>
    <dbReference type="HOGENOM" id="CLU_000022_19_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6V5"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:7334"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="PHI-base"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="868"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP50490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1425" mass="157178" checksum="8C618AC1DDFA21FD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6V7</accession>
    <name>B0Y6V7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo-keto reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_068290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6V7"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6V7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="325" mass="37021" checksum="C18FD870923799A1" modified="2008-04-08" version="1">MSYGSKKWQDWVLDEDEALPLIEHAYKRGINTWDTADTYSHGLSEEILGKALKKYSIPRHRVVILTKCYFGVTDEPNDGKLPPISACNRNDGDWVNRVGLSRKHIFDAVDASVKRLGTYIDVLQIHRLDRETPREEIMKALNDVVESGKVRYIGASTMAAWEFQTLQNIAARNGWHQFISMQNYHNLLAREEEREMIPYCLDSGVGLIPWSPMARGVLARPWGSRSSVRENTDATLQLLVRSRETEADKAIVERVEEIAKKKNISMAQVAIAWVLSHPKENPILGLSSKERIDEAVAAIKVQLTPEEIKYLEEPYRPKALTALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y749</accession>
    <name>B0Y749_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prenylated Rab acceptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_072560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y749"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072560"/>
    <dbReference type="HOGENOM" id="CLU_064105_0_0_1"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40392" checksum="6109F701DD0295D4" modified="2008-04-08" version="1">MDINNVRIQEIDCGAEEEYLLRPGRALYAAEQRRNGWPRRNEDYDASAGDVHSVDGIDLDLDDDSDSTVAYAVQLAMKDDEEWLVDKALERIRRAQLLGQKNVRLSQRELDALERKRMQTSGMEDVGQRNKVPKAASVASRPLRPVESSTNGGLGNLWTMRHGSSAPNGSIPRTFVADKKEMYESRARASGASARDDSPVLPRTSTVPNLQPRMSGPPTYSSVPRDSRSEVPLTYPSPRPPATFQNPPYARILPHGPQWVPSYQASYALATVPAGSQSHPGHMAYPATPASVLGDRHPLSRQHVSLNSTRGDLSSAADEEEDSESDNDGDRIHIVDVVRRKVPIGLQRRPSAAGGAGARAVHPRSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7A2</accession>
    <name>B0Y7A2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IZH family channel protein (Izh3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_073100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073100"/>
    <dbReference type="HOGENOM" id="CLU_029962_0_0_1"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7A2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="500" mass="56633" checksum="2DEFE7EE2054F535" modified="2008-04-08" version="1">MACTTQSMTLESYPDATSTSFATTPSEGTGLLRDRRRRHSFHTARKLSCDYDGDAIFLRVELFLAELERRMHWIEQYRKSHMVHIDSSLRRAYATLEAVRDSCSYASGELMGGGKKRAKILVETLEDRYNDALATKETLEQKAQAGVRLMESFLVELESRAHAVRDRGIYGALDDGWKAVDSKLVHAREVVDEGIEQARRAKDSLRESINRAILLAQEQRLITYADLPHPWRINPHILQGYRFSSSKVECLMSVFSVCNETVNIWSHLIGLFIVLSVAFYFYPLNPNFHLSTKTDVAIAAVFFFAACKCLVCSTLWHTMNSIANQPLMERFACVDYTGISLLVAASIVTTEYTAFYCEPVSRWTYILLTMSLGIGGVILPWHPTFNRNDLAWARVAFYVTLALTGFAPLFQLTYSRGFVWCLYFYAPVVKSILVYFAGACIYASQIPERWRPGLFDYFGGSHNIWHIAVLGGILFHYCAMQDLFANAFVRAKGECPSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7D1</accession>
    <name>B0Y7D1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_073390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073390"/>
    <dbReference type="HOGENOM" id="CLU_020076_1_0_1"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7D1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22117">
        <property type="entry name" value="F-box_FBXL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000096">
        <property type="entry name" value="F-box domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052301">
        <property type="entry name" value="SCF_F-box/WD-repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381">
        <property type="entry name" value="DACTYLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="430" mass="48831" checksum="7C8F1BB6730CE627" modified="2008-04-08" version="1">MDGDMNTSPDPFQLAGELHEPEQQHHDLESLATDSKLDECPKSPLVQLPAELLHQILSYLSATDLAQVSQTCHSLAEHATNELLWADLVNAYLPFKVHDPSPFKSFRDLYAAYHPCWFIPQHKIWFSDTEHTGNLILARYDPRRGVIEAYRVIAERRSRPFQVWESNPDVMVQPFDPKVSLWLDDPVLLLKNNHGRLPRYLHGETRMPMAIETQHVFNAFSLCSSESPPNLPVDPDKQWPPPIIPSEHRVYRDMEAQWSNWDQHPRSLANMSEHAFRIRRWAHFRLGMPMFTAGRSETLSTYATLDPHLYTPTKDKPYQGIWVGDYSAHGCEFLLFLQRDRDDEATGSSGEPETSPDEIVQKGSLEAIKLTGDPNVPRGQISFIAPDIGPGGMVRVAEEALFRGCRIVRSKGHVAGLGFRDGKLSINMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8J5</accession>
    <name>B0Y8J5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARS-binding protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_077560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8J5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077560"/>
    <dbReference type="HOGENOM" id="CLU_2757327_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041188">
        <property type="entry name" value="HTH_ABP1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18107">
        <property type="entry name" value="HTH_ABP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARS-binding protein 1 N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="70" mass="8178" checksum="DFA356EF61FD329F" modified="2008-04-08" version="1">MPQRKPISMSQKAALRAQKCLHPNVTQKDLRKWFQETYDHTLSSGLISDILSRKYDYLDADSEEELEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8W8</accession>
    <name>B0Y8W8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_078820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8W8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078820"/>
    <dbReference type="HOGENOM" id="CLU_088657_1_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="202" mass="22748" checksum="DCD214ACF2EB3E23" modified="2008-04-08" version="1">MPTKKRKSSKPQSPRTLDQAWQQLVEAPQFIQHRGGLTPTEESRIKDGFGILQESNRPSPTMVGNYWQFLKSVEKDCGSEMVGLCAAAFGRTAIGRMKYRLRVELALKVKENQANLHCEAVNKAVQAIKQKRKHAQTRDLGTLTGDVYELTKDDARMIANSDQIGGKIWLTDPYSVNTASFITIPISDELKTQFIIQRPKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y908</accession>
    <name>B0Y908_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_079220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y908"/>
    <dbReference type="HOGENOM" id="CLU_953088_0_0_1"/>
    <dbReference type="OrthoDB" id="4465793at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="33352" checksum="1F49A1AF110DE6DF" modified="2008-04-08" version="1">MDDIVANTNISNAVEDDKRGSSWIVISHSHRLSILKFISDSSPDALERLLSCFGCLKSEIFHVYKVVLSLVDPNAFIGTPDMERARSSVAMIKLQVLALQQPPENRFPISPKDGPRIQEYLEDVHYASHRAACEPLKLLSACVLNDLDIFGKVPDRVQNAKSNIGIINEIIEQTNIERGRRPEEGVIDLITLNHYWKLRRADSLHNKTEQKNFTDSNISIVRMLEQYPIGWKDLPISDLMCYKFDDDYYWKGFWDSVEPGRLDESQLITFIRTGSYPSKHHTQSPIDGHISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y978</accession>
    <name>B0Y978_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_080060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y978"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080060"/>
    <dbReference type="HOGENOM" id="CLU_1077590_0_0_1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="PhylomeDB" id="B0Y978"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="258" mass="29741" checksum="B81382F6821DF6C5" modified="2008-04-08" version="1">MSDSDGLRSLLKRIMTSSEHSDITISCGAYNHRVHRAIISAQSEVLAAMCHDNFLEGKTGKISLPDDDPEAINIMVQHLYGQNYEDTRPDLEDYGEDRALLNLKVYAIADKYNITSLEESAKAEFRAWAWSSQRTEPWGRVVEEIWKSNEFSGLHLVIEKQLADNIDRMLEDDWLPFIDMGLKLGRFSAAFLQHIIDKKNRVFYAIRDAKVRHELDVIDLKRKIKGYKNTIEQTKHTIEQLRNEMAADTYESDGSIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9C6</accession>
    <name>B0Y9C6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_080550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080550"/>
    <dbReference type="HOGENOM" id="CLU_047021_1_0_1"/>
    <dbReference type="OrthoDB" id="4455582at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="458" mass="53813" checksum="F4F4748CC919307B" modified="2008-04-08" version="1">MSSWTGAAAMISSPSSFHALPLECRQQILCDLPDIQSLKSAILSHSALYAAFYNYQSPIILQVIQRQIPADLLAYAVLCSHARNIEPWTRTKVLDILDLYFNRRLVESFQWTIRAALDLVKFHESVTFFANDYIDNALGLVAPLNFPIHAPSETEWCRVARAFYLQETIGHFFCFRNGGERWITGGIRYARPCPSEFHHREKFDIFFGKHAPWEMEQVGAVNEYLYWRISPAFNTIAAHDVELGYHTVYFSDRETWEAFMGSQHKRGFLLRGLTTLHQFVIRANHQSRIELVSVRNSRCSNWLLVNELEFLQRFAVGPLGGMFYRDLTAEQVDEVVRKPFAHDSDCGPRQAWQWAHNDARCYQYICDKEHRELRRFGYVMWDSQRLEQWRDLGGPFQVPQQEDDARAGRRWMAMWPLIEKRRKMYEHGARGWWDGENAEEIRWIHGEKSPETRRRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAL1</accession>
    <name>B0YAL1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_085040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085040"/>
    <dbReference type="HOGENOM" id="CLU_024566_8_2_1"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP49054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="288" mass="31709" checksum="FE812561F86A0686" modified="2008-04-08" version="1">METPAVQSRIKGSIFGVAVVDALGGPVEFQPRGSFIPVTHFIHNDTFDVPPGTWTDDTSMTLCLARSLIASKGNFIPQAAIRNYVKWHENGYLSATDECFDIGSGTRQALMIWRRYFDRSPHIRENDPNALSNAALSSNATHPYPTCAECCQIYTRLIVRALNGASKEELAEEFARINFTDVKVKQRLDRYSSLTDWENTDEEHIKSSGYVLSTLEAALWAFFTTSTFKSGAVKVVNLGDDADTVGAVYGGLAGSYYGLEEIPADWIASLQKKNVVEEIASGLCSLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAY5</accession>
    <name>B0YAY5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_086260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086260"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B0YAY5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="316" mass="35109" checksum="B559398FE3B83981" modified="2008-04-08" version="1">MPAPYSTRTTTDELVADYAPLIKGKVILTTGVSSGSLGGFFVQSIAKAKPEWLILAARNADKLAQMAAEIAKAQPDVKVRTLKVDLGSLESVRDAAAHVNSWDDIPVIDVLVNNAGIMAVDYQLSPDGFESHLATNHLGPFLFTNLIMKKIVAAKEPRIVVVSSDGHRLNPFRFDDYNFDDGETYNRWYAYGQSKTANMLFAISLAQKLGVKYNLQAFSLHPGVIWTNLGNHLDWNIEFGELRWKDFDAKPLERGAATHIYAAFDPSLKANNGAYLLDCHVADPVVDTVKSWATSSFEAERLWRLSEKLVEQEFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBL1</accession>
    <name>B0YBL1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_087010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087010"/>
    <dbReference type="HOGENOM" id="CLU_036632_0_1_1"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="PhylomeDB" id="B0YBL1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="41"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="383" mass="42442" checksum="0514000CB5B0C64A" modified="2008-04-08" version="1">MEGVSRTPSFASITDSDHGAYLLLVNVCLLIVLVFFIAAKISSSIYLKRRRTTTSYPIYVGTVVAIIQTIILQYAVKYGLGKKQGSLAADSFEQYSKYNYAAQLLYIIPVALSKLSTTLLVHMLTPQRGLQNACLATMGAIGIWTVFALCAIAFQCPLPDAWLYRPGRCTAKGALMYLVAITNILTDMAVLTLPFFMMHKVQMSHGKRVKILCAFCTRALLVTRHCTSYSTLMETQHRLTHNWATSDTTTILNIIRYYIANMYTNLIVACLPTLYHIFAGLHSGLITTRLPDNVELSTRRKGSIYGKQTPLSTEKRGSIYTGNGDSVVTTNVRTDSREGRLSRILSDDSGGTSASTKQLTMESRRDGVLKTVDIHVHVEHDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBS4</accession>
    <name>B0YBS4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proline permease PrnB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_087660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087660"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B0YBS4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="57"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="555" mass="61157" checksum="DFAB0DC539C62465" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC31</accession>
    <name>B0YC31_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_088720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC31"/>
    <dbReference type="SMR" id="B0YC31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088720"/>
    <dbReference type="HOGENOM" id="CLU_018791_2_1_1"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="PhylomeDB" id="B0YC31"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP48162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="459" mass="52899" checksum="A298EA6F02391133" modified="2008-04-08" version="1">MSVLLETSLGDIVIDLLVDESPKACENFLKLCKVKYYNFSPVHSVQKNFTFQTGDPLGPDSPESDGGSSIWGLLEGPVKRTFSLKLSPKLKHTERGTVSMATVPSSHDPDERLAASQFIVTLEDNLDYLDGKAAIFGKVVEGFDVLEKINGAFIDDQGRPLKDIRIRHTVILDDPYDDPPGLVVPAESPLPSKAQLATVRIADDEELDDNMDEEAMEKLRREREARAQALTLEMVGDLPFAEVKPPENVLFVCKLNPVTQDEDLQLIFSRFGPILSCEVIRDKRTGDSLQYAFIEFENQKDCEQAYFKMQGVLIDDHRIHVDFSQSVSKLSESWRNATISKRSQRGGFGGVAELEKKRQYRATDNVREQDAYGMVFDKGEARRRPVSRERRYSRSPKRSSRRDSRSPKRGLHRNRYRDRSDSRSPRREDSYRDRNRERSYNDERRDRRDDDRYRERRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC32</accession>
    <name>B0YC32_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_088730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC32"/>
    <dbReference type="SMR" id="B0YC32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088730"/>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="PhylomeDB" id="B0YC32"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="509" mass="56716" checksum="E0CAFB33AEF31418" modified="2008-04-08" version="1">MAVAIKETVSNFMERFHGHPENLPREPSAEEFQQLRKKYTDAGQGHVFAFVDELQTGERSQLFHQLSSFDPVRINELADKALNPPKADDGPASLEPLPDIATASILDSDPKDLEQWYEEGLKLVAGNKVAVVLMAGGQGTRLGSSAPKGCFDIGLPSHKSLFQIQAERIAKLQLLAQRISGKEAVIPWYVMTSGPTRKPTEEFFEQHKYFGLNKSDVIIFEQGVLPCISNEGKILMESKFKVAVAPDGNGGIYQALLTSGVREDMRKRGIEHIHTYCVDNCLVKVADPVFIGFAASKQVDIATKVVRKRNATESVGLILQKNGKPDVVEYSEIDKETAEAKDPKQPDVLKFRAANIVNHYYSFKFFESIELWAHKLPHHVARKKIPCIKEGTGEFFKPEKPNGIKLEQFVFDVFPMTPLEKFACIEVRREDEFSPLKNARGTGEDDPDTSKRDIMSQGQRWIEKAGGIVITEGDVVGVEVSPLISYGGEGLEFLKGREIKAPAFIEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCA8</accession>
    <name>B0YCA8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_089530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089530"/>
    <dbReference type="HOGENOM" id="CLU_745910_0_0_1"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="158"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="413" mass="47696" checksum="4598E78B7F0A9B23" modified="2008-04-08" version="1">MFSPEDESAISMYSSAVLTRLSAIQLTKNTEQKPGDSQEPGIMSTGNVNASVSKGLDSKTSNTFSNAYQTGSSNCEGEGNIFTKCENPLVPRLSCGQTASNNYLAYHNSSFKPRLEEGLVLSPQSLQLVPTKKSFYQGQVRNAHAMVKDTRPTKLSAFQRLPGELRWRIYDLVFDVHRVEVLRLRDKNPENNIKRVHYRLYHRQLRPRDPRTHVAPSNEGRFTCAPLPIALLITCRSIYRDTLCLFYSRMQFIFNTTRTVMRFLKITSKEAQMAIQHIELNHTMYSEPALLNFRWYKCMSDMSWYNACDDLTVYCKSLRVLHISMNIRDWPISLQVGERWSLPLLAFARYGPRLDWVDIRLQMGSFKQDQLEKVAREIEEQIMDPTAFQIREDERLARELAGPIKAKVLRLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCB7</accession>
    <name>B0YCB7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_089620</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089620"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="PhylomeDB" id="B0YCB7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="292"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP48248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="440" mass="46098" checksum="CF748D269CCB0C23" modified="2008-04-08" version="1">MASPVPRGLRQVLQKSPSDIVILSALRTPVTRAKKGGFKDTYPEELLSHVLKATLEANPNLDPALIDDVAIGSVLQELGGAKAGRMAQIHAGFPHSVPFHTINRQCSSGLAAITAIGNGIRAGALNVGVGGGMESMTRNYGSRAIPTVLWPELKESPSKDARDCIMPMGITSENVATRYGISRADQDAFAAESHKKASAAQNAGLFDTEIVPVKTLSFDPENPDAAPKEITVTKDDGIRHNISVEKMATLKPAFKADGTSTAGNSSQVSDGAAAALLMRRSTATELGLTASIQARWVATAVAGCAPDEMGVGPAVAIPKLLELVGMDVSDVGIWEINEAFASQALYSVRKLGIDETKVNPKGGAIAIGHPLGATGARQLATLLPELKRTGQDVGVVSMCIGTGMGMAALLLCLAFSILLSKPFHEFPQWEWIGCGAKTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCC4</accession>
    <name>B0YCC4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_089690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089690"/>
    <dbReference type="HOGENOM" id="CLU_101461_0_1_1"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="PhylomeDB" id="B0YCC4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP48255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="173" mass="19167" checksum="4215E2DBA07CCB37" modified="2008-04-08" version="1">MNRDWANSGAEIFTVHRLASGSICDSPNSLFELGALAHRLLTQVVVTGARVFGRAFAEAYKQASASSKYAQANKGKGGSSSTFASSGLTLEEACKILNVKPPAGGETNLEHVMERFKKLFDLNDPKKGGSFYLQSKILRARERIEMEIRQAERKAAQEKELREGWNPKVYKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD15</accession>
    <name>B0YD15_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC multidrug transporter atrF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_093930</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>voriconazole(in) + ATP + H2O = voriconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61912"/>
            <dbReference type="ChEBI" id="CHEBI:10023"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:61913"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093930"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="PhylomeDB" id="B0YD15"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001650">
        <property type="entry name" value="ABC drug exporter AtrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="804"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1225"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1258"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1295"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1335"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1366"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1491"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1517"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="197"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="892"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP47549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1547" mass="173211" checksum="EABFF4BAE493AB94" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD63</accession>
    <name>B0YD63_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Suppressor of anucleate metulae protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_094420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094420"/>
    <dbReference type="HOGENOM" id="CLU_012796_0_0_1"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF14">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="87318" checksum="02C49E1D7077A405" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD77</accession>
    <name>B0YD77_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-methylcitrate dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_094570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094570"/>
    <dbReference type="HOGENOM" id="CLU_021803_1_1_1"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="PhylomeDB" id="B0YD77"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="4">
        <location>
            <begin position="78"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="5">
        <location>
            <begin position="351"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="558" mass="62105" checksum="BDEC88EFD6486E2C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD94</accession>
    <name>B0YD94_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_094750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094750"/>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_1"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="PhylomeDB" id="B0YD94"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="164"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="414"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP47628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="539" mass="61060" checksum="42D4C0E1E36F1E9E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDF6</accession>
    <name>B0YDF6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rad21/Rec8 N terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_095400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095400"/>
    <dbReference type="HOGENOM" id="CLU_025342_0_0_1"/>
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    <dbReference type="PhylomeDB" id="B0YDF6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF70">
        <property type="entry name" value="RAD21_REC8 N TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G02900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP47690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="741" mass="82475" checksum="D371ED8209D5C958" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDV5</accession>
    <name>B0YDV5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096920"/>
    <dbReference type="HOGENOM" id="CLU_046577_0_0_1"/>
    <dbReference type="OrthoDB" id="5365129at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758441" evidence="1">
        <location>
            <begin position="22"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="349" mass="37996" checksum="1621268375FE0D9F" modified="2008-04-08" version="1">MAGNAIAFLLTALTAVPLANDLFPQSRGSSTVVRVAAGLSLPRDGDYARTGGNTPSIALFDESGERIGFKSGARHGKIGDGKFKDIVVEPINKDNSRAPAYLSVPSSGNDALCIADIYITPPSKEFWAFFGDVPKECGVAWYRSNLPVQRQNGDPFKPRCFWIDSPDTGKTTSSFPQGAGIHLTDFTANQGRVQQYQISRDTIPGPNEKPTAKQILQLQKWTGGRVSTPTYGVKTRSVKARQNDRVCFADHQVVVVSEHREHTASELCKSTSAAGPDFVSTKEGLFCDMCTGELWPLCSKNVPTGCFDVDLKVMRASDGAVTRTGLHARDVITGRDIPEKEYKKVAHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDW5</accession>
    <name>B0YDW5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphomevalonate dehydratase small subunit-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_097030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097030"/>
    <dbReference type="HOGENOM" id="CLU_141583_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="PMDh-S-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577:SF3">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="AcnX_swivel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomevalonate dehydratase small subunit-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="133" mass="14189" checksum="EEA47379F9A3B995" modified="2008-04-08" version="1">MQYHGHCLVDSAATGKLLYANVGLSFWAGVDSQTGEIIDRHHPLHGQSVNGRILAIPCSRGSCTGSIVLIELLLNQCAPAGLIFQQPEQIITLGVVVAKTLLGLSIPDQPSKPERTPSHHPPTKHLRAPPQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0YED1</accession>
    <name>B0YED1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidylate synthase</fullName>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_098760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YED1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098760"/>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="PhylomeDB" id="B0YED1"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000005">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP47275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="344" mass="38241" checksum="66F2131F3CC3DA59" modified="2008-04-08" version="1">MTIQSKDQTSIMSPAAVLPQDTPSQTGTPTPPHNPAHEEHQYLNLIRTILAEGEHRPDRTGTGTRSIFAPPQLRFSLSKPGATPSSDPIPILPLLTTKRVFLRAVIAELLWFISGCTSSIPLSEAGIKIWDGNGSREFLDKVGLGHREVGDLGPVYGFQWRHFGAEYIDAKTDYTGQGVDQLAEVVRKLKETPFDRRIIMSAWNPADLKKMALPPCHMFAQFYVSYPNGLDNKGSLSCLLYQRSCDMGLGVPFNIASYALLTHILAHATDLNPGTLIHTMGDAHVYLDHVDALNEQLKREPTEFPELRIKRNDRGSGVVDGWKEEEFEVVGYQPHKAIKMNMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEG4</accession>
    <name>B0YEG4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine synthase B, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_099090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099090"/>
    <dbReference type="HOGENOM" id="CLU_039949_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="PhylomeDB" id="B0YEG4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000057">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="382"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="58354" checksum="DA22D4D96D864234" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM21</accession>
    <name>B0XM21_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_001720</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM21"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_3_1"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="PhylomeDB" id="B0XM21"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="16" id="KW-0132">Cell division</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="15">
        <location>
            <begin position="459"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="712"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="828"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="868"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="910"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="950"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="557"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP55477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1079" mass="118708" checksum="1535550209B395D5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM35</accession>
    <name>B0XM35_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_000760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000760"/>
    <dbReference type="HOGENOM" id="CLU_026450_1_1_1"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="PhylomeDB" id="B0XM35"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF270">
        <property type="entry name" value="O-ACYLTRANSFERASE AUSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="510" mass="55999" checksum="FF2BF2E0F739ECBC" modified="2008-04-08" version="1">MSVQTTYSPVNQDEQVHDGLASRHVSCEGAPSDDSPYALSSLDHNPLGINVSFLLCFHAAQPEEGIRVLEDGINQLLKAHPFLAGDVTRPTRLSQRTNTMQIEPDAPESLLKIPMLQIRHHPATSIEELESKRLLPGAEEQEIIRQLAPLPIDMDLSLPQRPVLRFQANIMRDGVILAMTFHHAAMDGAGAARVLGLLADYCRDPAAPSVGVIPDRQLRSQIDRLATGCSPSASRADFSQHYCGLGDWAALLAENWPGFLQARATELVTWRLTIPGFKVQYLKGACNALLQGQTSALAGGTLTPTILSNNDIVSALMAMILRQAGQLAGKSTELSIAVDMRPSFHAPAFNNYLGNMVLLTYTPIPAAKDQAPVDGPRPPTELRQEDLEELTGIAARIRQSLLKVDAEYIQGVLSHLHSQTDWANIGFRGVPIPLSSFRNFEIFGLDFGETLGSQPRGFQLHLPVLGGMCFVLPKRQDRTEPWDLHLTLHRDDVSRIANDPLFRWAAGEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM84</accession>
    <name>B0XM84_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_001250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001250"/>
    <dbReference type="HOGENOM" id="CLU_493446_0_0_1"/>
    <dbReference type="OrthoDB" id="4509259at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="521" mass="52754" checksum="60AAE15B11BF2A3B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN39</accession>
    <name>B0XN39_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein translocation complex componenet (Npl1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_014480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014480"/>
    <dbReference type="HOGENOM" id="CLU_014210_0_0_1"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="PhylomeDB" id="B0XN39"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000019">
        <property type="entry name" value="Protein translocation complex componenet (Npl1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000081">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000169">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="633"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="671"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP56729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="697" mass="77760" checksum="378AEF30CC0ED933" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN53</accession>
    <name>B0XN53_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein dml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_014620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014620"/>
    <dbReference type="HOGENOM" id="CLU_022511_2_0_1"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="PhylomeDB" id="B0XN53"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="9">
        <location>
            <begin position="119"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="505" mass="57590" checksum="6B642F7C1AFB05EE" modified="2008-04-08" version="1">MHEIITLQLGQRANYLATHFWNLQESYFTYGEAEETIIDHDVHFRPGIGADGSETYTPRTLIYDLKGAFGSLRKYNALYELSTDADPGQGLWDGKEVIQRQTPIIPSEYQKYLEQGLPAPALSSDTVRYWSDYNRLFYHPRSIVQLNDYELNSKIMPFEDWSVGDDLFGELDKEHDLLDRDLRPFAEECDQLRALQLFTSSDDAWGGFAAKYVDRLRDEFGKKAVWVWAIEGGKKVQKHNQLKRDMNKARSIHSISPQSSLYVPILDPPTRLPISISLDAQSEWQTSALISTAMETVTLPTRLRSYTDFETSLAGEDGTHKIFELQSEILPEDMSNHTQPVQNPEDRRTQASKGGSSKVKREFDLDFSYDDPNNGDSHIFNQVQVGRGYSPEKEVPESREDLGLKRKERFYNSEPMLESFYIPLAFPILDSSPRNMFSVKHKEAKINVLAALTASSRTATKLKAMEAMAGRVIGVDERENLVNGLGEIRESYETGWMSDSDFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNP0</accession>
    <name>B0XNP0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FRG1-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_004960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004960"/>
    <dbReference type="HOGENOM" id="CLU_062276_2_0_1"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="PhylomeDB" id="B0XNP0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33673" checksum="3A5E2329C6A7BC97" modified="2008-04-08" version="1">MVKPLTFKGDKPKKRKHREIAATESKFGADSGTTARTPAEESQHLEDSAEDQSWVSADTPSDIAGPVVLVLPSDPPTCIASDANGKVFASELENLIEGDAATAEPHDVRQVWVATRVAGTESLSFKGHHGKYAFLSTTIPQRTRERMLTNCWDRYLSCDTYGILSASASAISHYESFLALPSTDIPGTFALQTGGGDKEAFVCVREASSSSKASGRVIEVRGDASSLGFETTLRVRMQARFKPRIKANKETKAREKISRKELEGIVGRRLEEHEVKRLKRARREGTFHEEVLDVRVKGKHDKFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP42</accession>
    <name>B0XP42_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar import and degradation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_005850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005850"/>
    <dbReference type="HOGENOM" id="CLU_022561_1_0_1"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60097" checksum="EE6568EF660B8F7F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPC8</accession>
    <name>B0XPC8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_016890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016890"/>
    <dbReference type="HOGENOM" id="CLU_044729_0_1_1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="PhylomeDB" id="B0XPC8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF12">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760492" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="33"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="405" mass="43952" checksum="D4FE5E6E1F5F50CC" modified="2008-04-08" version="1">MRSIHLLSSVFGISPVLAWTELHHAPFMNKNIDAIVAPGTYTSHMHTFFGSDAITNVLPTSAELQRGCYSGDNPNDLSVYWVPTLYYVDGDTFTEVAIFRFSTYYTNSYSDSAIPQDFAMISGNASAHSQAEADHPYNGLEWFCEGSSERESDIAKLPTSTCDQHLQLNLLFPQCFNPDDHSEYDFADESNTCPEGMLQMPQLRYRVQYDTKSVAPDGWSGPAPFQLSCSDTPGDGYCFHADFINGWFEDAAENMLINGGGDYEDGQFISGEHGTSAVKATCTPTDQDPDNGTSDYYTSLEMMDDGAAAGDAVASDATVATEDATSTSVAMETVMTFATQVAIPSTAMGPSASIQAQAPTQLLPLPVPTESGVNRGCHRKFRRNIGQKLKDAAAKRVLGALDARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPE6</accession>
    <name>B0XPE6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_006210</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006210"/>
    <dbReference type="HOGENOM" id="CLU_162182_0_0_1"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="PhylomeDB" id="B0XPE6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP55919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="103" mass="11306" checksum="B954DE5E9C93E115" modified="2008-04-08" version="1">MASGFGLNGGPSRCYGFWQEVLGCYVVNAGEGEAGKKKCMPALEDYYECLHHRKEALRTMKMQAAYRKAEAAHPRENAPKAEQIRSLGLLGKEEEASALLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPR5</accession>
    <name>B0XPR5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_007310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007310"/>
    <dbReference type="HOGENOM" id="CLU_002057_0_0_1"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760373" description="Galactose oxidase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="100849" checksum="E69922A7026254D8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ28</accession>
    <name>B0XQ28_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_008480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008480"/>
    <dbReference type="HOGENOM" id="CLU_030828_0_0_1"/>
    <dbReference type="OrthoDB" id="2405722at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ28"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="512" mass="56826" checksum="4B83767DC23B250F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ54</accession>
    <name>UTP25_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName>U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>U three protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">utp25</name>
        <name type="ORF">AFUB_008740</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ54"/>
    <dbReference type="EnsemblFungi" id="EDP56168">
        <property type="protein sequence ID" value="EDP56168"/>
        <property type="gene ID" value="AFUB_008740"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018705_0_1_1"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ54"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000408101" description="U3 small nucleolar RNA-associated protein 25">
        <location>
            <begin position="1"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="671" mass="76208" checksum="ACB286922BA6AD6A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ69</accession>
    <name>B0XQ69_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_008920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ69"/>
    <dbReference type="Allergome" id="8983">
        <property type="allergen name" value="Asp f AT_V"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008920"/>
    <dbReference type="HOGENOM" id="CLU_027686_5_2_1"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ69"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="28"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP56183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="386" mass="41850" checksum="864B59EE2B774F86" modified="2008-04-08" version="1">MSSQAPHSTLLIPGPIEFDDAVLQSMSHYAESHVSPAFVKVFGETLTLVRKLFQSTKPSAQPFVISGSGTLGWDVVASNLIEKGENALVLHTGYFADSFAACLETYGAHATQLKAPIGDRPSFEQIEQALKEKPYKIITITHVDTSTGVLSDIKRVTEIVRRVSPDTLVVVDGVCSVGCEEIAFDEWDLDVVLTASQKAIGCPPGLSILMLSGRAIDRFKSRKTPPSSYFASIANWMPIMQNYENNKPSYFATPPTQLVHALHTSLSQITARPMAERFAIHAQTSDRVKAAIADLGLRQLASQPESQAHAMTAIYLPDGLTPADVLPSLLKRGVIFAAGLHKEIATRYIRFGHMGVSVTDPARNDIDKAIVALKEALTEAKQAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ85</accession>
    <name>B0XQ85_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAB1 binding protein (Pbp1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_009080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ85"/>
    <dbReference type="HOGENOM" id="CLU_007072_0_0_1"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ85"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="183"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="980" mass="106621" checksum="ED3B619CFEF28588" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQI3</accession>
    <name>B0XQI3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_010060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQI3"/>
    <dbReference type="SMR" id="B0XQI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010060"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="PhylomeDB" id="B0XQI3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="293" mass="32888" checksum="811FB59EC95F724D" modified="2008-04-08" version="1">MSKFGVLVMGPAGAGKSTFCSALIQHLQTTRRSCFYVNLDPAAESFNYEPDLDIRELITLEDVMEEMELGPNGGLIYCFEFLLQNLDFLSQALDPLSEEYLIIFDMPGQIELYTHIPLLPSLVQYLSRQGPLNINLCAAYLLESTFVIDKAKFFAGTLSAMSAMLMLEMPHVNILSKMDQVRDMVSRKELKRFVNVDVNLLQDEIGGAEEPVEGDPSSKDTLLSGRSFKRLNRAVGQLIDDFSMVSFLKLDVQDEDSVAAVLSHIDDAIQFHEAQEPREPNDEQDVDYEDADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQK4</accession>
    <name>B0XQK4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like modifier SUMO, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_010270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010270"/>
    <dbReference type="HOGENOM" id="CLU_148322_0_1_1"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="PhylomeDB" id="B0XQK4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="93" mass="10400" checksum="04520127035BF649" modified="2008-04-08" version="1">MADNGTPSEAPAPPPVEHLNIKVTDNNNEVFFKIKRTTQLKKLMDAFCERQGKQLSTVRFLFDGTRVRPEDTPDSLDMADGDTLEVHQEQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQN6</accession>
    <name>B0XQN6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein Msh5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_010600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010600"/>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="PhylomeDB" id="B0XQN6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="498" mass="55608" checksum="28A9FC36D13D7D2A" modified="2008-04-08" version="1">MLNQGPGRKSPASKEGLSVYGLFQRFAHTPQGRNRLRQIFLRPSVEINVICERHDFISVYLRPDNYDALNKIVKGLKHIKNLRPVMINLRKGISTGSAKITGFKTTVWATLLAVDIDRSEDQGRTVVKPGLDRELDRMKDTYDGLNDLLKEVATEIAATIPESLDIDVNVIYFPQLGFNIAVPLNDMGEAAYSGTADDWELIFVTENRAYFKDFRMREMDQSLGDIYGLICEKEIEIIYDLAQKVLQHKDALVQASDMCGHIDGSEYNMVRPRMVEENMIRIKGGSLETEIRVPQEVALNVYLAQVGSFVPAEKAEIGVADKILVKMNSQESVSKIQSTFMNDLQQISFDLKQVTGRSLLLIDEFGKGTNESDGIGLACGILEHLLSLEDAPKVITATHFHEIFQNGFLQPRRRLQLGHMEVRISGKARQVEDQITYLYNCAEMNGINQMIVNRANDLAALSARGENLIAACATLSAEETETLAEAVGLSHIWGNVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR08</accession>
    <name>B0XR08_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_011830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011830"/>
    <dbReference type="HOGENOM" id="CLU_2996153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="57" mass="6438" checksum="FE7547F3EFF667B2" modified="2008-04-08" version="1">MPPDIFTYHRHTKQRLGPGLSLGNLAFRGLDGVCDSHIRNFVSIERTLNHGFVISFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR79</accession>
    <name>B0XR79_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G protein complex alpha subunit GpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_012410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012410"/>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="PhylomeDB" id="B0XR79"/>
    <dbReference type="PHI-base" id="PHI:4678"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010856">
        <property type="term" value="F:adenylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="179"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="356" mass="41040" checksum="8DF1F8BE4D148CB6" modified="2008-04-08" version="1">MGSCFSTESPGDAEQKKRSQAIDRRLEEDSRRLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTVEELALYRLTIYKNLLDCAKALIGAYHQFNLQPTSPKVREFIEFLSEYNIDPDPNTPLDPRIGDAVTYLWNDPCTSTALEHQNEFYLMDSAPYFFEEAKRIAAPDYIPNVADVLRARTKTTGIYETRFTMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESNQNRMMESLVLFDSVVNSRWFMRTSIILFLNKVDLFRQKLPRSPLSNYFPDYSGGNDVNRAAKYLLWRFNQVNRAHLNLYPHLTQATDTTNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR83</accession>
    <name>B0XR83_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_012450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012450"/>
    <dbReference type="HOGENOM" id="CLU_084522_3_0_1"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="PhylomeDB" id="B0XR83"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="166" mass="18613" checksum="149B8556D9B58828" modified="2008-04-08" version="1">MSFKNPSEIQVTSRQIPKWEGIPNTSIQSKPLVIYHKAFNASPNQLIARLKEVGETHFHSTTHEVLGVVSGRARLCFGGEDNPNRFDTDVEKGDLIIVPAGVGHRLLDELDTEEERFKMVGAYPKQKQWDMCYGQSGEEDKVKGIKDLGWFHKDPLFGGDGPVLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRC3</accession>
    <name>B0XRC3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C4-dicarboxylate transporter/malic acid transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_012850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012850"/>
    <dbReference type="HOGENOM" id="CLU_030057_6_1_1"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="PhylomeDB" id="B0XRC3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000005">
        <property type="entry name" value="Sulfite efflux pump SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758257" evidence="9">
        <location>
            <begin position="29"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="403" mass="44352" checksum="D942963E691D099F" modified="2008-04-08" version="1">MQMQQWPHRIHFLAAPLLMSIDFQSTTATNTRVRWFSVVMGTGMISTALNTLPYNGRWLYWISIVVFVLNVAIFAVCSILSVLRYTMYPETLNTIMNEPAQSMFLSTFPMGLATIVNMICFVCVPAWGNWTRDFAWALWMVDVCLSVISALYLPFSLMISNVDGQLSSMTAIWLLPIASCVVASGTGAVVADLLFNPNHALWTIIVSYVLWGVGICLSMIVYVIYFQRLTVHKLPHKGVIMSVFLPMGPLGSGTFAALKLGTAGKTVLSKTQMLNDSSAASIVYVVGAMTALILWAFGLPWLFFAFASVLKSGRFPFNMGWWAFTFPVGAYAMGTCQLGRQLPSAFFRVLGTVLSLIVVIHWMVISVSTLKGVVSGKIFVGPGVAKVQRQGKEENHSESISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRH0</accession>
    <name>B0XRH0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_002440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRH0"/>
    <dbReference type="HOGENOM" id="CLU_028208_1_0_1"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="PhylomeDB" id="B0XRH0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="216"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="481" mass="54440" checksum="686DDB8F174DCD2B" modified="2008-04-08" version="1">MEGRYILQHQSYSSTVDEVRREYPRTLQDHTWKIWHRSERIRLRFSMWKPASRATETASLSAQIWYFTSQGLKEPHAQALESILITECTGGDLESGAYRLQNVQLDVQAYQLRTHLDQERSHHILHDEELVDNVEDLGTTKVLILPSTELDGLWESQQTNEYEQSAVRPTSTVNTAPRHNSNGWVIFTDTALLGTSCNCLIVSFSARKLDKWTINWNRLILLWGPPGTGKTSLCRGLSQKLAIRLGKHYPQSKLVEINAHSLGSKYFGESGKLVSKAFESIELLLEEEEDSFVCVFVDEIETLAARRERALSSKEPFDAVRAVNALLTGLDRLKHHHNVIVICTSNLVTALVSVSSKALSRDLLKSVQDQAFLDRVDIKQFVPHLSNKTIYGIYKECLEELSWRGIIEGASFDVVQVKPEDPQTALQYVEQPARFLMLPMFEEMLLNYQIFPNAIPKQLADAASASVVSNRSRVEDITAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRQ0</accession>
    <name>B0XRQ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_013460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013460"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="PhylomeDB" id="B0XRQ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="161"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="689" mass="74808" checksum="6A7051F4C2769E9C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRZ2</accession>
    <name>B0XRZ2_ASPFC</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_025350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
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    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP54478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="157" mass="16448" checksum="F4C7FF3C56EBFED9" modified="2008-04-08" version="1">MMYSQVLDRLHQVATHLAPGINTISNTTGTLIELAKHNIPPPTALALHAHPRNIATYITQNPRQVVSICLFTFPQAVVSPVLYLMGFGSLGPIAHSFAAWHQASFGNPVAGGIFAHFQSAAMGGYGLSVLNTALRGIVGVATGVEMFGGRGNGTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS11</accession>
    <name>B0XS11_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_025540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025540"/>
    <dbReference type="HOGENOM" id="CLU_2941304_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="60" mass="6789" checksum="7B3EF52B88EDA184" modified="2008-04-08" version="1">MIMLLDAGRLRLFRSIKSSIELHPSSPSLPWQLSTPIHDGNYSPLYREFPVSQSLCSSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSZ8</accession>
    <name>B0XSZ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_028360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028360"/>
    <dbReference type="HOGENOM" id="CLU_1250396_0_0_1"/>
    <dbReference type="OrthoDB" id="10455148at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="221" mass="24808" checksum="93829B7C5CE88553" modified="2008-04-08" version="1">MIRRDNLQFCGGFLEWFLYFHGRRVGRDHFRICNARSDDEGRYVLGRITSDDSGIYGSAMTQVLILDSSWSAVERLTVTMLLVAITCLLARVPDCRAEPISCLATCSSSPLHLLYNPKSAISRSGRLISGRLTQTCIIFHPHILTPGCLDHLLANSRSLQKPHEGQNDQVSLGAKPSFAFDQAAYFNDKRLFFGIEAILASMECLNDAETMKIREFFARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU58</accession>
    <name>B0XU58_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_030420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030420"/>
    <dbReference type="HOGENOM" id="CLU_1377818_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760192" description="GPI anchored protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="19802" checksum="3E0CDD7DF253EAAB" modified="2008-04-08" version="1">MRVSAQLIAGLALVASANAGLYRRAHETSTSTEVTTTPTETATATPVVDQEVSATETNTSATTESEDVATVVSDADAHPTETTSIPLIKATVAVSSSAAASSPAAGISTSASPKATGTGDYVGFVDPNEESSTSSSHSSGSDSDSDSDSDSSSSSSSSSNDDAKESSKPTTSRHTNLGSTLVVPGLAALGSLAIGLMILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUB2</accession>
    <name>B0XUB2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_020120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020120"/>
    <dbReference type="HOGENOM" id="CLU_011759_2_1_1"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="PhylomeDB" id="B0XUB2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="68"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="419"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="568" mass="66064" checksum="0C69E359AB8B7408" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUJ1</accession>
    <name>B0XUJ1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_031070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031070"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B0XUJ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="514" mass="55796" checksum="44812C76BBAE81EC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUL9</accession>
    <name>B0XUL9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_031350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031350"/>
    <dbReference type="HOGENOM" id="CLU_014393_4_0_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="PhylomeDB" id="B0XUL9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000211">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="51"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="300"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="625" mass="69106" checksum="50B0171DA4C9F205" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUP9</accession>
    <name>B0XUP9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_020840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020840"/>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="PhylomeDB" id="B0XUP9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="235" mass="25126" checksum="9E199FB8E346483B" modified="2008-04-08" version="1">MKAALIVVDMQEDFCPPDGSLAVQGARSIAPLINSLLASPGFVIRVASQDYHPRDHVSFASNHPEPNNRPFESVIQMNNPAPGKESETKEQRLWPVHCVGGTKGATIIPEIDSSKIDLHVKKGMDSRVEMYSAFSDAFGNLDPAVHAQSVDVDLKAVLAERGITHVFSAGIAGDYCVKYTAMDAARAGFKSFLVEDATRSVDSGAGWEEARRECEAAGVSIIQSDGPEIAALTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUQ2</accession>
    <name>B0XUQ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_020870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020870"/>
    <dbReference type="HOGENOM" id="CLU_2497462_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="86" mass="9496" checksum="9A8535EBE4FFAA2E" modified="2008-04-08" version="1">MGGAPGVWVKSRFSIYDIPEDIYFRNSHIYETISPEPPISPIPRAFRSPSAPRAVLSPRSLLKIKSGIQDARAFDDQTIPSAPSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUZ7</accession>
    <name>B0XUZ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_031990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUZ7"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="B0XUZ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF135">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="46"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="491" mass="53370" checksum="B7B225E90AF19471" modified="2008-04-08" version="1">MSKSESTNQREKGIDSELEEANIVDWGGPNDPINPKNWPKHRKWTHIVIISLLALTTNMAPTMCAPGISGISADLDITSSAVSTLAITLYVLGLAIGPMFMSPVSEVYGRVPVYHAANIIFVAMIIGSALSWNLAQFLVFRFISGCAGGTPMALGGGTIADITTIEQRAVAMAFFSMGPLAGPSDLVQVLGPVIGGFLAASKGWRWTFWLLAILGGFCSVSAFVIMSETHPKVILERKTASLRADTGNHHLRSKLAGNPLSPHQVVVQVLIRPTVLLFRSPILFVISLYVALVFGVMYLLFTTFTSVFEGQYGFSTSVSGLVYLGPGFSLVASMLIFNILNNHLQSAQSKADGVQQHRPENRLLPMIWFSPLVSLGLFIYGWTAYYKVHWMVPIIGTAFMGFGAFFVMMPAQLYLIDVFGSQAAASALGANNLLRYIFSTFLPLAGPSMYEALNYGWGNTLLGFLALAFVPGPLLFYRYGEHLRARTSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV05</accession>
    <name>B0XV05_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_032070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV05"/>
    <dbReference type="HOGENOM" id="CLU_030044_0_1_1"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="PhylomeDB" id="B0XV05"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000356">
        <property type="entry name" value="Translation initiation factor 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="494" mass="53192" checksum="B8AD8754AE702577" modified="2008-04-08" version="1">MSIGTFLADESLGSWADEMEDMPLPSPPSQPSYGGDRRGAGPPSGAFGNGLNDRGGYATREPLPLPTQPPYTAHVGNLSFEATSADINDLFAGCGVTNVRIVEDKLTRSPKGFGYVEFETVDGLRRALDLSGTTLQGRAIRVSIAEPPKERDVKELDWTRKGPLPAPEQPPRRVPDRSTFGRNLDNLSDAGSERAGARRNFESDGKVRDFGNWERKGPLSPVTGPVREGGRPRSNEGPGFRRSSPAWGEGRSQDGSRPPRREFQERTPTAAELDNSWRARMRPDQPPAKEPSNPPSPAATPASPAAPASRPKLNLQKRTVTDTPSSPAPSTDSKASPFGGARPIDTAARERQVEERRQLALRQKKEAEEKAKAEKAEKQRQSKEQAKSEKSVPAADPNGKDSMDIPQGGKNFEILRQAGEDEGGAAEQEQPEEAPAAAAGDEASKQAPASKTNGNWRSGGPTQPAEAAADEEGWSTVSSRQRNNRRGQSGRTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV17</accession>
    <name>B0XV17_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial inner membrane translocase subunit (TIM17), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_021330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021330"/>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="PhylomeDB" id="B0XV17"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="154" mass="16255" checksum="C29CE666D688AD63" modified="2008-04-08" version="1">MDHSRDPCPWVALSDFGGAFCMGAIGGAVWHGVKGFRNSPYGERRIGAITAIKARAPVLGGNFGVWGGLFSTFDCAIKGIRKKEDPYNAIIAGFFTGGALAVRGGVKAARNSAIMCAVFLAVIEGVGIGFQRMMADNTKLEVWSLTIALCYDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVF2</accession>
    <name>B0XVF2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cellular morphogenesis regulator DopA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_022040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001197_1_0_1"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="PhylomeDB" id="B0XVF2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="403"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1375"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1863" mass="207683" checksum="CD14AB2C3645D420" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWM9</accession>
    <name>B0XWM9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_046670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046670"/>
    <dbReference type="HOGENOM" id="CLU_2978717_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="58" mass="7000" checksum="59DAAA8050A2730B" modified="2008-04-08" version="1">MMETRKDKMIFGPALRCRRSLVMSWEDRYIHKDAAIPIGEEDKWIIISMAPYITRDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWU4</accession>
    <name>B0XWU4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_036440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWU4"/>
    <dbReference type="HOGENOM" id="CLU_010293_0_1_1"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="PhylomeDB" id="B0XWU4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.650:FF:000005">
        <property type="entry name" value="Transcription factor TFIIIB complex subunit Brf1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="237"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="338"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="539"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP52478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="749" mass="81730" checksum="A8446A72E7FBA9F6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX08</accession>
    <name>B0XX08_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_047310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047310"/>
    <dbReference type="HOGENOM" id="CLU_002678_42_18_1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="PhylomeDB" id="B0XX08"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF22">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="127" mass="14738" checksum="D1BFEB4ABD9DAAFF" modified="2008-04-08" version="1">MTPAMLLPSLRKFKCPWAHCEKSFNRKSDLCRHHRIHTKERPYHCTVKGCNKSFVQRSALTVHFRTHTGERPHACNFAGCEKAFSDSSSLARHRRTHTGTKLYNCPERTCHKRYDSPLVQQGARTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYK7</accession>
    <name>B0XYK7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_041250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000654_0_0_1"/>
    <dbReference type="OrthoDB" id="2582433at2759"/>
    <dbReference type="PhylomeDB" id="B0XYK7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF630">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="949"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1372"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2936"/>
            <end position="2985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2971"/>
            <end position="2985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="3014" mass="337803" checksum="8257E8BAA8990F43" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYT1</accession>
    <name>B0XYT1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYB DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_041980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYT1"/>
    <dbReference type="HOGENOM" id="CLU_509930_0_0_1"/>
    <dbReference type="OrthoDB" id="5398572at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="534" mass="60374" checksum="C5AC1535874178EC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYV6</accession>
    <name>B0XYV6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_042230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042230"/>
    <dbReference type="HOGENOM" id="CLU_017779_3_2_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="PhylomeDB" id="B0XYV6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP53052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="577" mass="63130" checksum="B1EC44267FB489D8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYX1</accession>
    <name>B0XYX1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine phosphate oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_042380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042380"/>
    <dbReference type="HOGENOM" id="CLU_078856_0_0_1"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="PhylomeDB" id="B0XYX1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="243" mass="26690" checksum="02C41EB523A6CE19" modified="2008-04-08" version="1">MTDSLNPPLSYEASATTTHPLVATTLPSEVIACLKNSRFLHLATCNGLTPHISLMSYTYLPSTPFDPYPTIIMTTNPSSRKTNHLMTNPRVSLLVHDWVSHRPPTRAPNPSGQRDGSPPPVATRSSLASLLLNLNTSALSSISTTITGTARFLEPGSEEEAWCKERHLENNTFEEELGMFGQQQQAAGQRRPSLSIDNDVRVVTVRVREGRIADWKGGVRDWKLVSESESQADEPLVNGTMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ01</accession>
    <name>B0XZ01_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_042680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042680"/>
    <dbReference type="HOGENOM" id="CLU_064339_2_1_1"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="248" mass="28230" checksum="ECE5F868E81D7C8E" modified="2008-04-08" version="1">MEAADLLPLLEQLDDNFDDLEEALKPILESPVLETSKKLPVLDKAKFHVLVTYALESLIFSYLRLHGVNAKEHPVFRELIRVKQYFGKIQALETEPEQRAMTLDKEAAGRFIKHGLAGNDKLDMKRKEQEAKEKARAQLRAALLAKKAAASETSSRNRTSSSDSESESDNEASDSEKSMIAGSEQLGNPLETTEPEDSQEVKKKKDNNKHETSKAIRKRMKRSKEEQQERNKERRQKKMEARRAAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ34</accession>
    <name>B0XZ34_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_043000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043000"/>
    <dbReference type="HOGENOM" id="CLU_011003_0_1_1"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ34"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="742" mass="83308" checksum="E8FC53985EB434EB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZR4</accession>
    <name>B0XZR4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_044970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044970"/>
    <dbReference type="HOGENOM" id="CLU_009665_20_3_1"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="PhylomeDB" id="B0XZR4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="515" mass="57416" checksum="00DE6A3C4C41D5FF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZV8</accession>
    <accession>Q4WYY4</accession>
    <accession>Q6U819</accession>
    <name>PLB3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Lysophospholipase 3</fullName>
            <ecNumber>3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phospholipase B 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">plb3</name>
        <name type="ORF">AFUB_034540</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="FEMS Microbiol. Lett." volume="239" first="87" last="93">
            <title>Characterisation and expression of phospholipases B from the opportunistic fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Shen D.-K."/>
                <person name="Noodeh A.D."/>
                <person name="Kazemi A."/>
                <person name="Grillot R."/>
                <person name="Robson G.D."/>
                <person name="Brugere J.-F."/>
            </authorList>
            <dbReference type="PubMed" id="15451105"/>
            <dbReference type="DOI" id="10.1016/j.femsle.2004.08.019"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Glycobiology" volume="13" first="169" last="177">
            <title>Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins.</title>
            <authorList>
                <person name="Fontaine T."/>
                <person name="Magnin T."/>
                <person name="Melhert A."/>
                <person name="Lamont D."/>
                <person name="Latge J.-P."/>
                <person name="Ferguson M.A.J."/>
            </authorList>
            <dbReference type="PubMed" id="12626404"/>
            <dbReference type="DOI" id="10.1093/glycob/cwg004"/>
        </citation>
        <scope>STRUCTURE OF GPI-ANCHOR</scope>
    </reference>
    <comment type="function">
        <text>Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Lipid-anchor</topology>
            <topology>GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Strongly induced by lecithin.</text>
    </comment>
    <comment type="PTM">
        <text>The GPI-like anchor contains a phosphoceramide lipid group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5"/>
    <dbReference type="EMBL" id="AY376593">
        <property type="protein sequence ID" value="AAQ85123.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZV8"/>
    <dbReference type="SMR" id="B0XZV8"/>
    <dbReference type="Allergome" id="8988">
        <property type="allergen name" value="Asp f LPL3"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="B0XZV8">
        <property type="glycosylation" value="15 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP52290">
        <property type="protein sequence ID" value="EDP52290"/>
        <property type="gene ID" value="AFUB_034540"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034540"/>
    <dbReference type="HOGENOM" id="CLU_014602_0_0_1"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="PhylomeDB" id="B0XZV8"/>
    <dbReference type="BRENDA" id="3.1.1.5">
        <property type="organism ID" value="508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000372613" description="Lysophospholipase 3">
        <location>
            <begin position="17"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000372614" description="Removed in mature form" evidence="1">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="2">
        <location>
            <begin position="39"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-like-anchor amidated asparagine" evidence="1">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAQ85123." evidence="4" ref="1">
        <original>Q</original>
        <variation>E</variation>
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAQ85123." evidence="4" ref="1">
        <original>N</original>
        <variation>D</variation>
        <location>
            <position position="542"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAQ85123." evidence="4" ref="1">
        <original>G</original>
        <variation>S</variation>
        <location>
            <position position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15451105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="630" mass="67417" checksum="0E83E7D7F149CA08" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0G1</accession>
    <name>B0Y0G1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_046070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0G1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046070"/>
    <dbReference type="HOGENOM" id="CLU_058099_0_0_1"/>
    <dbReference type="OrthoDB" id="10260248at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758100" description="PBP domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PBP" evidence="2">
        <location>
            <begin position="32"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="305" mass="33033" checksum="BEA4DE37F75CAF6A" modified="2008-04-08" version="1">MLQSVFSLAFLVASCLTVDPAAVYTGGYSAGSVRLRIGNGGAGQSGLIKALADAFIQSSVKNGSSPFKVAWYKSDTTESINYLKDDTIDVGITYTPAAEEIAIKQGVAKSPAWYAWRDHFLLVGPPSNPAGLKKADDIKTMFSHIYAVASAGDAANVAIPVRFLTRYDKSATNIKESQLWIEIGQVPWATKYSTWYHQYIAYPIQALTAAILLEEYTITDRGTYLSIDQALAHKTTIYKAATDDPADPLLNPAHMLVGKKASNMKMADKFTQWVISAEGQAVITGFKKNGKQLYTAAPANKTAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0I5</accession>
    <name>B0Y0I5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS allantoate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_046320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0I5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046320"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0I5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000245">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="513" mass="56972" checksum="093D7128445A144E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0M4</accession>
    <name>B0Y0M4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_057830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0M4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057830"/>
    <dbReference type="HOGENOM" id="CLU_081335_0_0_1"/>
    <dbReference type="OrthoDB" id="4505626at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758520" evidence="7">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="305" mass="31908" checksum="8F433A2074368AB5" modified="2008-04-08" version="1">MAPLSSRIFPVAIGALALTPLTSAWTLTWRNSTAGATIINENKAENCTRIWHQKGLPFAWDPEGKWCMHFYKDAACTQIAGYACDGKVWRQDASRDLPAFDVFPMPPESVSVIFPSTSSTATTPTSTAVTTTASQSPSATSAAASTAPTTSPTPSPSPASSSSTLSGGAIAGIVIGAIAAVGLIAALFFFFGRRNRKPAQPAEPDPRSTTPPTPQFPPGSPLGLVSTNDTAAAPAPAYIVPNKRELAEAEMSQAYAHGYGHPRAYAGAKFVELPGNGAEAELSNSRQVHEMDGTSDIKRPIYEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1E5</accession>
    <name>B0Y1E5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_060050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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    </dbReference>
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            <end position="422"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="13"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51975.1"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="550" mass="61778" checksum="6581C595C1D037C5" modified="2008-04-08" version="1"> </sequence>
</entry>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
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                <person name="Turner G."/>
                <person name="Venter J.C."/>
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                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
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                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EDP52061.1"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
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                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000152">
        <property type="entry name" value="Extracellular endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002413">
        <property type="entry name" value="Extracellular endoglucanase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005102">
        <property type="entry name" value="Carbo-bd_X2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016282">
        <property type="entry name" value="Glyco_hydro_5_endoGlcnase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF41">
        <property type="entry name" value="ENDOGLUCANASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03442">
        <property type="entry name" value="CBM_X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001043">
        <property type="entry name" value="Endoglucanase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760638" evidence="10">
        <location>
            <begin position="24"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="11">
        <location>
            <begin position="60"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate binding X2" evidence="12">
        <location>
            <begin position="370"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="575" mass="62495" checksum="18173833BFE4855C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2B2</accession>
    <name>B0Y2B2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_050840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2B2"/>
    <dbReference type="HOGENOM" id="CLU_020336_20_1_1"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2B2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="85"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="343" mass="38364" checksum="7D0C266FE0F38384" modified="2008-04-08" version="1">MAPLTAQEIIAHPAYDTVDWKLPPTTSGRALVAQNRRGGPINLNYEIHGTGPVKLVGKYDANANQWIMGLNAALKDWKRQTKYFGHLNGSKYSCLVFDNRGVGRSDKPTCFYSTSEMARDVVDLVSSLGWIDMKAPATRAIHVIGASMGGMIAQEVAMLIPDRLASLTLCCTAPRLVRTTPFFENLQQRASMFIPRHVDVEIDRIAATLFASEFLAQPDTENEDPALNFPTKRDRFAAGHLRKKADTESYTPKGFLLQVTACYFHHKSAEQLMALGDAVGRERILILHGTEDRMLTFRHGELLREEIGEGITWKVFEGAGHMLGWETEHEMNESIQDLVDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2D7</accession>
    <name>B0Y2D7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_051090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2D7"/>
    <dbReference type="HOGENOM" id="CLU_012437_1_2_1"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2D7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="648"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="673" mass="76568" checksum="2E7432963ECEB83D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2J1</accession>
    <name>B0Y2J1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_062000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2J1"/>
    <dbReference type="HOGENOM" id="CLU_020689_0_0_1"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2J1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="787" mass="86974" checksum="6FC7C6E08BC3B135" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2S0</accession>
    <name>B0Y2S0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Stress response RCI peptide, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_051740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051740"/>
    <dbReference type="HOGENOM" id="CLU_107649_1_2_1"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2S0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="92" mass="10220" checksum="EA8F8833CF498B68" modified="2008-04-08" version="1">MASTASMLCLILVTLFIPPLGVLMISGCSVDFFINILLTILGYLPGHIHAFYLEYVYYRNSSTDPMTRKRAPGVYSQRILQGHDGRTYGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y317</accession>
    <name>B0Y317_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SIR2 family histone deacetylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_052620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y317"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052620"/>
    <dbReference type="HOGENOM" id="CLU_023643_1_1_1"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="PhylomeDB" id="B0Y317"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="381" mass="41534" checksum="D9D86214DFECB22C" modified="2008-04-08" version="1">MTKPSIRIPLTGPLPPPIIVPPSASTLSGAINAVLSFFTAPPSPYLSGVDVGRHSQAVLLTGAGISVASGLSDYRGEKGTYVTNKFYRPIYFHEFLSRHESRKRYWARSFVGWPGLLKAEPNSTHWAIRDLAAKGFVSSVVTQNVDSFHSIAHPELPTIELHGHLKSVVCTSCRNQFSRAEFQKSLERLNPAWAEFLARMVEAGALDTNNPEEQRRKGFKLNPDGDVDLAEAPYSTFRYPSCPTCLENPPRLKDGTLARVEVEKDGAWLPSSTAGILKPAVVMFGENIDPGVKTAAEEAIDDAGRLLILGSSLATYSAWRLVERAHRRGMPIAIINLGGVRNESVLFETSSDVSSSHVRCSFPSEAILPPVVSLLPKSIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y329</accession>
    <name>B0Y329_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial DNA replication protein (Yhm2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_052740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y329"/>
    <dbReference type="HOGENOM" id="CLU_052717_0_0_1"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="PhylomeDB" id="B0Y329"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180056">
        <property type="term" value="F:citrate:2-oxoglutarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="117"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="218"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="298" mass="32080" checksum="D543FDC1A322E47C" modified="2008-04-08" version="1">MSATTAEKASTGRTLEKKPVKFSNLLLGAGLNMFEVTTLGQPLEVIKTTMAANRGDSFAGAMARIWGRGGILGYYQGLIPWAWIEASTKGAVLLFVASEAEFRAKVLGAPDFLAGIAGGMTGGVAQAYATMGFCTCMKTVEITKHKMAAQGVKPPGTFATFMDIYRKEGIRGINRGVNAVAIRQTTNWGSRFGLSRLAETAIRKVTNKDENQKLSAIEKVIASGLGGGLSAWNQPIEVIRVEMQSKKEDPNRPKNLTVGKTFKYIYETNGIKGLYRGVTPRIGLGIWQTVCMVALGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3Q1</accession>
    <name>B0Y3Q1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_055000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
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                <person name="Silva J.C."/>
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                <person name="Angiuoli S."/>
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                <person name="Dyer P.S."/>
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                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
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                <person name="Sundaram J.P."/>
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</entry>
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    <accession>B0Y491</accession>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Joardar V.S."/>
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                <person name="Badger J.H."/>
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                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
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                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
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                <person name="Sundaram J.P."/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4V3"/>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4V3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018484">
        <property type="term" value="F:4-hydroxybenzaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047770">
        <property type="term" value="F:carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046185">
        <property type="term" value="P:aldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="514" mass="56427" checksum="2E456DDB60125D15" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y558</accession>
    <name>B0Y558_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_071480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y558"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071480"/>
    <dbReference type="HOGENOM" id="CLU_1119942_0_0_1"/>
    <dbReference type="OrthoDB" id="4466753at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="248" mass="27843" checksum="281B74F5F28931C3" modified="2008-04-08" version="1">MYSGDIQTCLGIPIPMSMKDLVRAPPVCLPTRGDQETIEILEKFGKALLRPEDEVAQAQNLAAGFSDIVVLLERPRHRRDHKFDVSFEDFVKSCKTLLALDELIRFATKGARSIYTVTVLDAFSYQPDKYATEQDKQCHEVLAQILRAKKPKVILRCHRGAYCDEWLKQVELPGENYRLGRKEICIVNDHTTVVLQSFHPSCAGLIDVPLCGSILGIDVPVCSAGNSGRNKKAVPQKWRKKTRGHSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5F5</accession>
    <name>B0Y5F5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxin 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_063220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP49990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5F5"/>
    <dbReference type="HOGENOM" id="CLU_039527_0_0_1"/>
    <dbReference type="OrthoDB" id="5407351at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5F5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF4">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 20 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44403" checksum="A6F09E481DEF0ED4" modified="2008-04-08" version="1">MSDTLCGPSNALQNLQKHASVDRTLQQDRLISRRSPSQGFRSQNSSDGVLDPEFAAFESDLAGPSLPNLQHAGPFSAHPHRLPVASHAENVTWAADFQRLHISGPSHPIQQHHGPSATPASAMSQQGWHSEFLKQQQQRQAPTQQHQQYTGGFQPSFSPHHPIHGGVINALPSVHRPATDQQHATETFDESAFEAAFEQARADMALQETNATEEKAEPASETIQPDLSTAQEPTEQIKIGSDTIPQIDKNDPLSRVNDADELARTAGQLLDSVSHDQSEKFRKSSFLALMRRIRDREVRIEDDEFRETSQSLHPGGKYYPGGQQQAQRQQTSIPTHQDGPDGVTFGDISPVYRVRNDNAPIQGLTRCNVPNRSSATPRDIPSASSTGAGLGEDNSLYASWNYGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5I1</accession>
    <name>B0Y5I1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_063480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5I1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063480"/>
    <dbReference type="HOGENOM" id="CLU_093937_1_0_1"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="171" mass="18563" checksum="4BC1303FCE51F44C" modified="2008-04-08" version="1">MGKAKNANRPLTQEEIWDDSALVQSWDEAVEEYKLYHSIHAKGEDVEDVLREAEAAERAGLDQDRQQPDEAADAMEDDDAVATTASTAAEQSSSMQVPDAVEEHAAATDQQPSGMKHPTQPAPAGAAAMPYAALAQVQDEGLKNLMMAWYFAGYYTGLYQGQQQASQNNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5I9</accession>
    <name>B0Y5I9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentafunctional AROM polypeptide, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_063550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5I9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063550"/>
    <dbReference type="HOGENOM" id="CLU_009960_0_0_1"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5I9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="730" mass="78987" checksum="351BD67868AFAED5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5X8</accession>
    <name>B0Y5X8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal subunit Rpl38, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_064950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5X8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064950"/>
    <dbReference type="HOGENOM" id="CLU_152057_1_0_1"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5X8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="80" mass="9284" checksum="58488AAB1A97D57F" modified="2008-04-08" version="1">MPREVSDIKQFIEICRRKDASSARIKRNRATQQIKFKVRCHRFIYTLVLKDSDKADKLKQSLPPALKVVDVSKGDKKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6G5</accession>
    <name>B0Y6G5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_066880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066880"/>
    <dbReference type="HOGENOM" id="CLU_569822_0_0_1"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="231"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="479" mass="51978" checksum="8CC8906BC4B5350F" modified="2008-04-08" version="1">MSGTHFPQWNYSTSVSRYVNSKSSASPSQQGEGTPNLASSCSNHEPPPPFIFQGTQCYDPPAVSPATESRFSSVHSWVGGAEQRHNGASASADSLPQSKVLRASQSRGGDHWDSIAPAGADSIGQTQMRWSGSPTDADYSQFPHQGVSNDYHGQISISPREYTRDVDSSNSTTIPSPVHSDRSSAALNGRFNLIQALPPQPPRQVSSGIPMGFDRLLNHSPEPSPVPRRVSTSPRYHLHIRQQPIAARACGAGDRDRRPVDPPPIIQMLLTDFDPQSQADLDTLQDPRLTVGCLLLPVSAANSWPGSPEADGLWANREDRTTSQRAEENGPGRGTPLLSGKAFVSPFHVELDPDPHTAPPHPTSANYKVETKPGAANPSNGLDLAKVQVPATFFVFPDLSIRSAGVYRLQFRLMNWGLVEDTGQSMPVLAEVWSDPFRVYPAKDFPGMRDSSPLTEALKELGFVELKTRGKGKGKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6Q7</accession>
    <name>B0Y6Q7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_067800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6Q7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067800"/>
    <dbReference type="HOGENOM" id="CLU_028123_2_1_1"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6Q7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="411" mass="45766" checksum="1AB3CCDE524D4289" modified="2008-04-08" version="1">MLDGRIKAVPFEHAGNKVTVNTVPPVFNATASPLALIPLQPTLFHCFAIWGFSRPQRSSPLEHQMVLRLINGLGVYLGTLYVAHGFCASLEHGGYLLVDGHQSERLAQHEAGIRHYFASLLPAKAFVRCLLDHSILCLRPKRLIWQRIDDGARQLILVMARAFPSHRVHVKTRVTVPLMDKKAQFDHLIFAISADGIQHILGVTPTIGETEILQKLRTARHIMFFAFGSIYPPDITPRTCLTCVMNEGQNLSIQHFDLVLITLDPFAPPHPLLVAEVWEFTDLGICTDTLQVLSSLPAIQSKRGLSFCFSWTGHGVLEDAVTSGLTVAVEHLDAKVPFAFEHHPDISDVTELPQLHLSLADHLIRTLLSLFRVYVLVIEISLILLGALRGSLKNRMCLPRSERPFVLVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6R5</accession>
    <name>B0Y6R5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_067880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6R5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067880"/>
    <dbReference type="HOGENOM" id="CLU_046346_0_0_1"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6R5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="185"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="237" mass="27280" checksum="5B20C182A0FAD2F6" modified="2008-04-08" version="1">MKLNISYPANGSQKVIEVDDERKLRPFMEKRMGTEIPGDSLGDEFKGYIFKITGGNDKQGFPMKQGVLLPTRTRLLLSDGHSCYRPRRTGERKRKSVRGAITNFDLAVLALSIVKQGESELPGLTDTVVPKRLGPKRATKIRRFFGLDKKDDVRKFVIRRTVTREGKPDYTKAPKIQRLVTPQRLQRKRHRIALKRRRAEAAKEAANDYAKLLATRVHEEKAKRDELRKRRASSMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6R7</accession>
    <name>B0Y6R7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMG box transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_067900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6R7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067900"/>
    <dbReference type="HOGENOM" id="CLU_010453_0_0_1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF320">
        <property type="entry name" value="BOX TRANSCRIPTIONAL REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="688" mass="76079" checksum="FE6E6BAAB5860803" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6S2</accession>
    <name>B0Y6S2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_067950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6S2"/>
    <dbReference type="HOGENOM" id="CLU_2527029_0_0_1"/>
    <dbReference type="OrthoDB" id="10322878at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="84" mass="9573" checksum="FA6EFF1987313D21" modified="2008-04-08" version="1">MFYGSCRMIKTDTRLSPFSQPWSSFDLTGHDSTSTSRTTGLPAEKVTAVGLLSWHYSTGTHYHYLVQLVYLKTRLCSFWAEAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6X2</accession>
    <name>B0Y6X2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Involucrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_068440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6X2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068440"/>
    <dbReference type="HOGENOM" id="CLU_006409_0_0_1"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6X2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160:SF19">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="4">
        <location>
            <begin position="71"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="5">
        <location>
            <begin position="672"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="394"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="887" mass="100061" checksum="FE9021B53D25DD4A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y716</accession>
    <name>B0Y716_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_072230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y716"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072230"/>
    <dbReference type="HOGENOM" id="CLU_086140_0_0_1"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="PhylomeDB" id="B0Y716"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043528">
        <property type="term" value="C:tRNA (m2G10) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="138" mass="15446" checksum="2B2AE1250DB4473C" modified="2008-04-08" version="1">MKLVTANFLTCAVKGCKTSSASFPLHFQDAELELEELDFQPEFIRNIIPRVDWDGLRVTANELGFSNLPEKKPEGEALNDEQTLKDLHRLLLETHVIEGKLVCGNCGHEYLIKEGIANFLLPSHLGLGLPDRIYIVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7C0</accession>
    <name>B0Y7C0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EF hand domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_073280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7C0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073280"/>
    <dbReference type="HOGENOM" id="CLU_009681_0_0_1"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7C0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF187">
        <property type="entry name" value="EF HAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="9">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="446"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="585"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="870"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1099" mass="123966" checksum="8DD73E2A7F2DCD66" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7C9</accession>
    <name>B0Y7C9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_073370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073370"/>
    <dbReference type="HOGENOM" id="CLU_047849_0_1_1"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7C9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="315" mass="35875" checksum="E3A26E642AEA5B60" modified="2008-04-08" version="1">MFSGTQAHKYRLKVTAGAEYNPESHKIVPVNRDQTLRIESGLATRLTIRKQGYPDDSPKTHPYFSHPLHRNDQYSISFAIVFKKPVNSNDLIFGHDFDRPIRDRLPPGFNAALKLVKWTIDPAMDGDAYADKPHLYSPAVAALNQFRIGETIAKNDEVPTVHDVVVEEGADGSGVEERAQRGIPEGVAERRKMFQNEEERQKFVFEPGRVYSADFGNPYLVFNDFSLRLPGLTVHATKFIDEKNHDLRYVLKNRETGEVYFVVLFTLILLDMEKEPEVKERSKQEFQEGTGKHGENEGKLGKFEWEPEPSAGDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7G2</accession>
    <name>B0Y7G2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal biogenesis factor (PEX11), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_073700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7G2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073700"/>
    <dbReference type="HOGENOM" id="CLU_049216_0_0_1"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7G2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="235" mass="26089" checksum="D441B2982983857F" modified="2008-04-08" version="1">MVADALVYHPALAHYLRFVATTVGRDKILRTLQYFSRFYAWYLYRTNRPQSAIDPYNAIKKQFGTTRKILRIGKFVEHLKAAALAADNKSPIDPVLRYLAIGRQLGYAGYLTLDTITVVDVIGVKKLAAAKRLQESAYRSWMAGLACSAIAGVYTLWRLQEKEKTLDRKEGEGVVEAKKLEKERAAARIQLISDLCDLTVPISALGLASLDDGIVGIAGTISSLIGVWAQWRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7W3</accession>
    <name>B0Y7W3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_075230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075230"/>
    <dbReference type="HOGENOM" id="CLU_000445_50_4_1"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7W3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000329">
        <property type="entry name" value="Hybrid sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000131">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF76">
        <property type="entry name" value="PHYTOCHROME-LIKE HISTIDINE KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="8">
        <location>
            <begin position="397"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="766"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1184"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1011"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1087"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1342" mass="148662" checksum="A7330EB145B37633" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8A6</accession>
    <name>B0Y8A6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_076670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076670"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_1_1"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8A6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="381" mass="42808" checksum="4D0846937C7E0DD7" modified="2008-04-08" version="1">MFPSPPSPHLEAIENWRILYSLIAAYLSRSQLKMPFAQLVIGPPGAGKSTYCNGMHQFLGAIGRKCSIVNLDPANDKTSYPCALDVRDLVTLEEIMSEDQLGPNGGVLYALEELEEHFEWLEEGLKDLGEDYVLFDCPGQVEIFTHHSSLRNIFFRIQKLGYRLIVIHLIDSYNLTLPSMYISALLLSLRAMLQMDLPHINVLTKIDNLSNYAPLPFNLDFYTEVQDLSYLLPHLEAESSRLSHAKFGALNNAIIDLVEEFGLVAFETLAVEDKKSMMNLLRVIDRASGYAFGPAEGANDTIWQVAVREGLGTMDIRDVQERWLDAKDEYDAQERSELEAEAKAREQAAQPPPREDDELDADLANFRGSLPDSGVKVIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8C0</accession>
    <name>B0Y8C0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 1 (TTC1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_076810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8C0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076810"/>
    <dbReference type="HOGENOM" id="CLU_058463_1_0_1"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8C0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="277" mass="31398" checksum="6BFA431DC58F0008" modified="2008-04-08" version="1">MTTENSDKNPDEFDPGSDSESEDVFHDARFPAEEEARLLRESHEIKTEANKLFTAGCYDQAISCYDRALASCPNYLDYEVAVLRSNMAACYLKLEDWKAAVDSATTCLDRLENIIPLSQQNQDEDLPKQNSQLSKQTDAVIEISGENEEAEKEELKRLEKMDEKKNDVMRIRAKALMRRARAKSQLGGWGNLQAAEEDYKVLTGMENLPIDDKRVVQRALRELPARINHAREKETAEMMSKLKDLGNGILKPFGLSTDNFKFVQDPKTGGYSMSFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8F1</accession>
    <name>B0Y8F1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_077120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8F1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077120"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_2_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8F1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="48"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="558" mass="61106" checksum="0D87BFB1C5F21781" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8F9</accession>
    <name>B0Y8F9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_077200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8F9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077200"/>
    <dbReference type="HOGENOM" id="CLU_014699_1_0_1"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8F9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="292"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="435" mass="49486" checksum="C433D24A54E92323" modified="2008-04-08" version="1">MDAPATPVLPTSDEYPEIPIIDDNESLADIIRKLRNFLNVAVPDVACTFEQLRSSAYGYKLRLLIGSLAENSHNPRIVSALMILKWQLNNEDSDSDWGLNESRGYACEYIAWQFLCHLTRREMIDVLLEELPSPRRDSATISQAEQGASGLGSVSHEDEGNETEGERTPLLLSSSSSLYRLFVGKSHQGDSYAGDNRGSRGWYYDDPELHSFSPFFGLNALEIATIAHAKKFLSQKAVQRVIDDIWNGEIVFWDSLSVHSKKKPQFFNKRTADPYSRLRVPMYRKAFEAAFFVSFLFLYYAVLVERKPTGIGIFETLMYVWIAAFAYDELSGMVDAGMLFYQMDFWSLWDMGIIAIGLVFVIARESFAPVAIPWPAPAKATSMHRFFLRLLTDLGSQVSLDWPKVAIILRTYHSTYCHWKLCFWFQGKASATIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8K8</accession>
    <name>B0Y8K8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_077690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8K8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077690"/>
    <dbReference type="HOGENOM" id="CLU_533134_0_0_1"/>
    <dbReference type="OrthoDB" id="4526966at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="511" mass="58000" checksum="2FEFC95545121EE8" modified="2008-04-08" version="1">MRLRNDPELHIIHCDTDWLQQDLYDGGNTQEPQLINCVRIFEGYRSKYVPKSKYLHKVLEVENLELTDRASPTSEWSYESEFEKLFSYPFVSSYKPCLQVSREELSALALILGMNLCVCESHNPYSLHGEGAFGISASATLSHDMHWQLRFVRTSRRPRHDPSAGSGYSTLFAKYLACGAIPFARGNSENDSKWIKSVYIQDLNKFEEGGYFKDLKDDDCLPDALEYLSRLPTSETTMLWPHLLETQSTNRHKDWGLVKTIDNQTTGTWWDAVAGIPFGGLVPQTTREIKQAVQFTVSELPTVLDITTRCESDSLLNELEMLINESHRQHESLNLFGNHVHERAKSLDTDINFVTKCYDTRDAAAVFGRYMTLLEHLSATCFPGGSANDLESLHGQVSAYLKRSYRTWIASDSKKDTKDVLQKLGIVIKGVRRAYEETRTLSPDQTAKVTCCLIAAWAENVQEINLGLRRRSQDSIANHGRIANGEMINDQGRQLDHTTYMEDLPPIIALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9B7</accession>
    <name>B0Y9B7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080450"/>
    <dbReference type="HOGENOM" id="CLU_2482933_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="87" mass="9911" checksum="6230C9043E93E377" modified="2008-04-08" version="1">MSYWRHKKRLVSLSASHHPQTRRGPVARRMPAPGHGSRVALSTSMDYRFLGAVAHFGEERDVPEIDRLQLRQLPLDSMDARSDGTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9I6</accession>
    <name>B0Y9I6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_081180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9I6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081180"/>
    <dbReference type="HOGENOM" id="CLU_036632_0_0_1"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9I6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="320" mass="34899" checksum="6A5791F256F45EDB" modified="2008-04-08" version="1">MAGTLPPLFPISDEDHSGYVAVTVYTLLSLTVTTVFVRLFTRWYIARDVYSDDVLLTGATGLGILQSAFVQISIDHGLGKKIRMVSTSDLTSFDKYMYGAQILLLATVACSKCSVALLFRSLTAQGNALRLSQGLMVVIGLWTSSSILALAFQCALPHPWDMTGRCVNREALANYIWSMNILSDAALVFLPCVVLHKVQIRGLKRLRIMAMLATRLVVMMNLSIITTAIPSLGRLMIELQPSHNAFAITERHGFSGDKYAISSLSGHFVRDHTINEGLGTHSSVHGQRQAQNGDTESTEGLVGDAAGANRITKTVYFEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA07</accession>
    <name>B0YA07_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_082930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082930"/>
    <dbReference type="HOGENOM" id="CLU_035756_0_0_1"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="PhylomeDB" id="B0YA07"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="156"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="236"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="445" mass="50307" checksum="615CE5301E237CEB" modified="2008-04-08" version="1">MGAGAILEPLVVIVLLFGGTWINRSTATFSAVRRVRRSSTSTRANSPDSLESGLSSPTAKDALLNSRTPSPTLVQLNDARWRKRQIRILSYTFEVKSPDTAVFQDRLLSRLLRKFPFLVECWYWALVYWTYQLGRAFTAVTLQEGTVDVARKHALQIIQIEKSLRIFWEVSIQRVFLRHSQLMSVINWVYSFIHIPGTIAFLVGLYYYTTTRNRVDESQIGKPLGAAKGSTAGPLLYQARRRTLAVCNLLAFVVFTLWPCMPPRLLSDENVKGPDGELGRSYGFVDTVHGVNGAGSVWTENRFCNQYAAMPSLHFGYSLMIGLTIMTIPLPSHRRRPAVRSRLLGRALGFRLPSWSRLACLLVGFLYPFVILVAIIATANHFILDAVAGTVVCVLGWRFNSILLNLLPLEDYFLWLVRIHKPEPTAMDNVDYWDDDEVPDFPALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAL7</accession>
    <name>B0YAL7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pathogen-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_085100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085100"/>
    <dbReference type="HOGENOM" id="CLU_066755_0_0_1"/>
    <dbReference type="OrthoDB" id="65445at2759"/>
    <dbReference type="PhylomeDB" id="B0YAL7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053218">
        <property type="entry name" value="Pathogen-related_defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723:SF10">
        <property type="entry name" value="PATHOGEN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723">
        <property type="entry name" value="PATHOGENESIS-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27723" checksum="05DCD43200922CAD" modified="2008-04-08" version="1">MGDADALPDYVLDPNAVLNDKAAAWRHGAPPDYSKTRAFYEETKQMTHEAGSLPDLVSSLVKNWEIEASFKTSLDDWRTIDHSKYTFSLNGGPPQTGDHMLWVGTYNALLTSSAYYDPEHNDFSTSHKAFKRMMPTFAWEVLEVYSGPPVVIFKWRHWGYMKNDYVGYNNRGEKVTVKAHGGLIDIQGIVIAKVNSSLQLEKIDVWFDPMDMFRQIAREEKIEGENKEGVDAAGAAAGCPVMGHRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAS9</accession>
    <name>B0YAS9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactose 4-epimerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_085710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085710"/>
    <dbReference type="HOGENOM" id="CLU_053163_1_0_1"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="PhylomeDB" id="B0YAS9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="280" mass="30963" checksum="2B6B7B1076E6E71B" modified="2008-04-08" version="1">MKIAITGARGTVGRTTVKVCADAGHATVQVNRTEQPPGAIPNTEMRTADVAMNYQQTVEAFRGCDAVIHLAAIPNPVGKDEYAVHNNNVDSAFNGFRAAAEVGIKRFCYASSVNAIGLAFSNRPLHFDYFPIDEEAPQHPTDAYALAKREAEIQAQAFAEWFPGMKIACLRIHEVSSLERVQKVHANDWENAGVKQLWGWVNPVATARACLLAVEKCDNWEGCEVFNIVAPTTTQDLPSEKLARKHYPDAEIRADMSGNQGFWTTDKAKQLMGWEHYETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAW4</accession>
    <name>B0YAW4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_086050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAW4"/>
    <dbReference type="HOGENOM" id="CLU_1717681_0_0_1"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="PhylomeDB" id="B0YAW4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP49157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="173" mass="18713" checksum="9DEE7F17BD75AC30" modified="2008-04-08" version="1">MWVAAVYTNTISCTLVYSIAIVVYNEGGLAAIPVVKNLIGAIGLGCYCWGTTIIFDGGKELHGLKAVAVLMIVGIFATTGHAQDFRDRTADATRGRKTIPLLLSQPVARWSLATITAAWTIGLIALWKPPAIVTLAYVAASLRCLDGFLSSYDEKDDYVSYCWYGITVLASWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBB4</accession>
    <name>B0YBB4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_092210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092210"/>
    <dbReference type="HOGENOM" id="CLU_1992112_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="125" mass="14087" checksum="EF9A95CAE7428B40" modified="2008-04-08" version="1">MTCQHSNYEVIQKQEPFVVAFAPPHPQRAKNAFLTEPFPSFPNFKSAAIEHQATNIVTQLTPPVIWICLRQGATRVRQIPVLCRSGPLSLRPRDRRVSEAARKRPILLDIVTRQRVIGVVVSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBJ1</accession>
    <name>B0YBJ1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Plasma membrane hexose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_086780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086780"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B0YBJ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="424" mass="47235" checksum="3CD73FD0A892BA00" modified="2008-04-08" version="1">MNAVYPVAKVIGLFPATWIGDRYGRKKVLYTGFALLPIGAAVQAAAQNTPMFIVAGFLIGFATSFLSQPSPILVTELAYPTHRATATALYNTCFYLGAVLAAWSTFGTFRLQSTWSWRIPSLLQQAIPAFQTAFVFWVPKSPRWLMANKKEEESRRILTKYHAGGDENSPLVEFELNEIAQALELEKASEHAPSYFELWNGCSVLSYYLALVLNTIGITAPAHQTLINGMLQIFNWIVAVCGGALLVDRVGRRSLFLVGTSGMLLSYIAWTVLNSEFAKTHDQRLGSAVLAFIFIYYFFYDISWTPLPVAYTAEIFPYTLRGRGMTINFVGTYFGLISGQFLNPIAMKDLSWRYYIVFCAILFVMVLAIYLWVPETKGRTLEEIAEVFDGPRSHLTAGAVDENSAKGSGKVPEVEFREDVATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBQ1</accession>
    <name>B0YBQ1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase, GNAT family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_087440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087440"/>
    <dbReference type="HOGENOM" id="CLU_013985_1_2_1"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="PhylomeDB" id="B0YBQ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000047">
        <property type="entry name" value="Acetyltransferase, GNAT family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="240" mass="26779" checksum="35AF66DB88434E79" modified="2008-04-08" version="1">MSHRPLGPVVALPPAQLPSEVTLIGRTVALTKLSADHAAQLFPLVGGDDATKIALWDYMADGPFSDPITFQEAIAAKSRSSDPFYFAVIDIRQNPDPEKGHAVGYLSLMNIVPQHLSIEIGNVLFSPTLQRTTVATEAFYLALKYAIDDLGFRRVEWKCNALNAPSRRAALRLGFTFEGIFRQHMVIKGRNRDTAWFSMLREEWEGGVKGAMEEWLQESNFDESGGQQKSLEELRMGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBS1</accession>
    <name>B0YBS1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_087630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087630"/>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="PhylomeDB" id="B0YBS1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="307"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="401" mass="43436" checksum="D21E4782C90EDC58" modified="2008-04-08" version="1">MMSPRIAIVGAGPAGLTLGALLHEHSIPFTIFELRQKPTAEDLSMPSGMLDLHEGSGLAAIRACGLYDEFLKHTGDCAETHKVADKDGHILYSDEDDSNMRPSHRPEIARYALLTILLSKVPQDRIKWGHKLLAARRTGVSTETELDFGPQGKQTFDLVVGADGAWSAVRALLMDIRPHYAGLQSITLTVENISTRYPQLAALIGRGGFSSLGLRNGVMTQRGPRDSARVYVFFTAADGFTGEGKRAASVTKEQLLSDEALLGRFGDSVKELVAVGVACDKTADLPEGVVEVKPLYMLPVGAAWAHKPGVTIVGDAAHLMCPWAGEGVNLAMCDALMLAKVIVKFQTALDPLLRQFEEDMVTRAKEKAEETVSNGQMMFGDDGARGLAQFFRSMGQQQYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCD7</accession>
    <name>B0YCD7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM5</name>
        <name evidence="13" type="ORF">AFUB_089820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089820"/>
    <dbReference type="HOGENOM" id="CLU_076902_6_1_1"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="PhylomeDB" id="B0YCD7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP48268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="83" mass="8992" checksum="EE921047856103FC" modified="2008-04-08" version="1">MASQLLPLELIDKCVGSRIWVIMKGDKEFSGTLLGFDDYVNMVLEDVTEFDYSGAQVKLPKILLNGNNICMLIPGGEGPVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD93</accession>
    <name>B0YD93_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_094740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094740"/>
    <dbReference type="HOGENOM" id="CLU_2184654_0_0_1"/>
    <dbReference type="OrthoDB" id="4410922at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="130" mass="14501" checksum="709F70A06976EC03" modified="2008-04-08" version="1">MSQRPTSSHDSSAPHHIPVDDCLTYDTGYRPNLPGQRTWWVFCPVTGAFDNSYALLGAMIECVARGQATLAPAWDRTFAGGIWYDFDCGADVLDGRLLMDMAVDDMQRRIERYMSTNDGQMGCKPALGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDJ9</accession>
    <name>B0YDJ9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_095850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095850"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="PhylomeDB" id="B0YDJ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="29"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="412" mass="46012" checksum="3C7524DBFB0F4F26" modified="2008-04-08" version="1">MSVLSTLAPVPPDEIFALNRAYATDPFPQKVSLGVGVYRTDDGKPWPLPCVREAEKQLLAEDSLTRHEYTAIEGDIPFLELARDIMFGFDGKNAAEKHKSRIGSVQTVAGTGANHLGALFLATHMKPGKVWLSNPSWANHMTIWELAGVPRKTYPYYNPTTRSFDFDGMMATLEAEAQQGDVILLHACAHNPTGLDPNKEQWKAIADLCERKKIFPFFDSAYQGFASGSLEEDAWAVRYFLNEKPGMEMCVAQSFSKNFGLYGQRVGAFHYVLPQGSESLRDTVVVNLCHLIRGEYSMGPTAGCNLVKKVLTNEELTAQWHKDLKVMSSRIRSMRKALYDELLRLQTPGSWRHIVEQNGMFSYTGLTPAQVHSLKDKYHIYLLKSGRASISGLSEKNVAYVAQAIDDVVRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDL5</accession>
    <name>B0YDL5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_096010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096010"/>
    <dbReference type="HOGENOM" id="CLU_059426_0_0_1"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="379" mass="41017" checksum="E84FBF87F3E98D7B" modified="2008-04-08" version="1">MSTNPHEFGDPNRQGQYPPPPQWNSSQPEDNPAPANYPPASQYPYPPASYPPPTTDHPYPHPPPPPSQYPPTSHMATIHPHVQGAQDPYRLPPPPGAYRPPDVYAQPAPPPQPQVVYQAAAPRQRTAIACRYCRRRKIRCSGFESSQDGRCSNCIRFNQECMFTPVSSQAQAFVPAHAAYPHLRNPQNGRAGPPVMLYGAHGQPLPPQQQPQPPADTTLPPPQGMYQHPYGTAPPPLASAVPADHRPTGRRGSGSGFEYPDPTNLAPVTPATSAPAYQAHPAPSPYYPPPPQHDRRPSPQSAYPYDSRHSSSPHSSPYPPLHTATSTMTPPPTSTPGGSVSSSRGGLNVRDMLNPGDNQGRSSTDSDMLNALNRRGLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEE4</accession>
    <name>B0YEE4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial ATPase (Afg1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_098890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098890"/>
    <dbReference type="HOGENOM" id="CLU_008681_1_0_1"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="PhylomeDB" id="B0YEE4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001493">
        <property type="entry name" value="Mitochondrial ATPase (Afg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="563" mass="62860" checksum="93B74689D37B9BF5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF53</accession>
    <name>B0YF53_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C6 and C2H2 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_101600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101600"/>
    <dbReference type="HOGENOM" id="CLU_037785_0_0_1"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="PhylomeDB" id="B0YF53"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF36">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP47166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43300" checksum="93F8CBE1446F901C" modified="2008-04-08" version="1">MPPQPLSGSSLPPFQCDHPGCGAKYRRKEHLNRHAASHSRGDCFSCPDLLRRHIRIYHPNRAPPASRAQKACAACHARKERCYGGFPCSACQKRGIACSPGKGKTPEEQIVDNNVQISQQPHPPRWIALDYVDIYFDNFHPKWPFLHRGTFDVTKEPCVLIQSVVMIGLWIEGSKKSREAATDLHRSLSTAIRTQMDRWRVFNQNQSTSWPMATYQSVLLQCIFALFLAWERKAIDLNLRYQIQDDEHDLLVTLVESCRLGGIFSYPNMLAQHSSGVPLTLVWLSLEEIKRFGLALYKVCRLSTRLDPSRADGSSAQSELLTLADLSFGMPDSDEAWNSISGVGCEVRQEEAFQTKLRDGQDPTGWISQSASVLSNARVAFDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM49</accession>
    <name>B0XM49_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_000920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000920"/>
    <dbReference type="HOGENOM" id="CLU_031555_4_1_1"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="PhylomeDB" id="B0XM49"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40292" checksum="0D441C360A33520B" modified="2008-04-08" version="1">MEEENHIIDPDGEVIIIVHNPNARFAVWHDENAPAGESAEPQKLDGIAYEPMFPSDSHSDASNDEPANGSVGKLARIPSEADVRIQVSAKHLMLASPVFKKALTGKWKEGSTFVGTGSVVITTEGWDVEAFLILLRILLCQHHKLPKRVSLELAAKIAVLADYYQCNDLVGFIRDAWITCLREELPVTYSRNLILWLWISWYFNMPLKFKKATSVAMSQSKDKIDALELPIPARIIYEMNQKRQQAICRIILQLQQERDAFMTGTKGCNFECRSIMLGSLTGQMYKKGLLESEVKFYYKGCNVQDLTKSVQSFVAPKWRPAAFNGPGGYAIHQCPHSSFSLPSGSGNTVEGLKLKQFLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM52</accession>
    <name>B0XM52_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_000950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000950"/>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="PhylomeDB" id="B0XM52"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="89"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="558" mass="62791" checksum="E95A1FEB76B53108" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM97</accession>
    <name>B0XM97_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloalkanoic acid dehalogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_000310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000310"/>
    <dbReference type="HOGENOM" id="CLU_045011_3_2_1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="PhylomeDB" id="B0XM97"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="237" mass="26674" checksum="4B0A7247032B79AE" modified="2008-04-08" version="1">MSKLSDYRLLCFDVYGTLVDWESGIVNTFQPILDKNNSSISREHLLSVYHELEHEQQAQTPDMPYSKLLTKIHPKLAHRLSLAPPTEEESIAFGESVGTWPAFPDTVDALKRLSKHYKLVVLSNVDRESFAKTNAGSLQGVKFDRIITAQDVGSYKPDLRNFEYMLKTVQAELGVDKSQVLQTAQSQFHDHQPASKVGIKSVWIVRPGAVMGNTKHTIYDWKFDTLGDMAHAVESGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XME1</accession>
    <name>B0XME1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_001400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
            <location evidence="2 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0XME1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001400"/>
    <dbReference type="HOGENOM" id="CLU_001128_3_1_1"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="PhylomeDB" id="B0XME1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 13" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 13" id="KW-0698">rRNA processing</keyword>
    <feature type="repeat" description="HEAT" evidence="12">
        <location>
            <begin position="588"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="BP28 C-terminal" evidence="14">
        <location>
            <begin position="1500"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="12">
        <location>
            <begin position="1759"/>
            <end position="1797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP55445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1798" mass="198998" checksum="97D43ECD76D67662" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMX8</accession>
    <name>B0XMX8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_003670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003670"/>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="PhylomeDB" id="B0XMX8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="267" mass="28315" checksum="D87C0F74DE6C52DD" modified="2008-04-08" version="1">MHDITLDPLLLGNLTGKTAVLTGGAGGIGTAIAKLLLEHGANVVVADLEHTRPIVETMIVDLPGSCKGRVQFVATNISAKERFGSIELVIANAEVMERTPVLDMDQIDEHGNLEESHEFCKVIDINVKGTMNCLRHAIFSMKGNQPCYPDGSRGAVVLVSSISGYFGGTGVSGYITSKHAVTGMLRGSQLVASQYDIRVNAVAPFVTPTAMAGGFSEAWQAKGLPINTTEGVATVVLTLAVNPAEKGSCYIVWRSIWHRDNGALLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN95</accession>
    <name>B0XN95_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF726 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_004170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN95"/>
    <dbReference type="ESTHER" id="aspfu-q4wk44">
        <property type="family name" value="Duf_726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004170"/>
    <dbReference type="HOGENOM" id="CLU_001695_1_0_1"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="PhylomeDB" id="B0XN95"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035650">
        <property type="term" value="F:AP-1 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035652">
        <property type="term" value="P:clathrin-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="984"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1120" mass="121964" checksum="BD5A936BD299FADA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNB2</accession>
    <name>B0XNB2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_004340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004340"/>
    <dbReference type="HOGENOM" id="CLU_018649_2_0_1"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="PhylomeDB" id="B0XNB2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000002">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="616"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="646" mass="71791" checksum="4B441323DC4EE146" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNC0</accession>
    <name>B0XNC0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RNA polymerase I specific transcription initiation factor Rrn7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_004420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNC0"/>
    <dbReference type="HOGENOM" id="CLU_016553_2_1_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="PhylomeDB" id="B0XNC0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRN7-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="12">
        <location>
            <begin position="55"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="13">
        <location>
            <begin position="212"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP55745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="527" mass="60602" checksum="4C78F0CFEA666173" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNQ4</accession>
    <name>B0XNQ4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_005100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005100"/>
    <dbReference type="HOGENOM" id="CLU_045411_1_0_1"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="PhylomeDB" id="B0XNQ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000033">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38682" checksum="D7CBD6F5D7BEABC6" modified="2008-04-08" version="1">MGATDVPQAQAVTVSLQELVNGTVSFETLTEAFGPSSLGIIVVKDLDPAFPRLRAQVLSNASYLAALPNNELESLTSPAAKYLVGWSCGKETLRSGHFDTLKGSYYVNCAFYQNPDLQGAPADNFHDLSEYTAPNIWPPADRLPTFRRSLEELCTLIIDTAALVARACDRYALANIDGYKEGYLEHVVKTSLTTKARLLHYFPTDPAAAANAEAEDDDDWCATHLDHGCLTGLTSAMFVDEAANPPSLTDASTPLAELPQSPDPKAGLYIQSRTGQVVKVNIPNDCLAFQTGEALQLITRGKFRAVPHFVKGARPSGRARIARNTLAVFTQPNLEEEVEPGKTFAEFAREVVSRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP77</accession>
    <name>B0XP77_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidative stress-induced growth inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_016370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016370"/>
    <dbReference type="HOGENOM" id="CLU_026100_0_0_1"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="PhylomeDB" id="B0XP77"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="60638" checksum="016C858FB0F69D8B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP96</accession>
    <name>B0XP96_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TfdA family taurine dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_016560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016560"/>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="PhylomeDB" id="B0XP96"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF20">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="36"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="349" mass="38920" checksum="43DD9ED0E52AFEBB" modified="2008-04-08" version="1">MPSIAASIRGGHEQARPSISQPLEYSGSLDSFSYLDLTPVIGREYTGLQVVDLLSSPERDRLIRDLAVTISQRGVVFFRNQDITPQQMREFMDKLTVLAGCPQSSGLHVHPLTEEGSELGDQISVISSEKQKKGGGLTHQLSDTSRFASVGWHSDISFERVPSDYAMLKIHTLPPTGGDTLWASAYEVYDRLSPAMATFLEGLTATHDASFFHDEARRLGNPLRKGVRGSPLNVGEELQAVHPVIRTNPVTGWKSVYVNRGFTKRINGVTKDESDVLLQYLFNLVTQNHDAQVRFRWNKNDLAIWDNRSTWHCATYDYAEARAGDRVCSLGEAPYLDIHSKSRKEALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPI9</accession>
    <name>B0XPI9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_006640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006640"/>
    <dbReference type="HOGENOM" id="CLU_025799_0_0_1"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="349"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="621" mass="66835" checksum="929D0295C33A35A5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPZ3</accession>
    <name>B0XPZ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIRM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_008080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPZ3"/>
    <dbReference type="HOGENOM" id="CLU_042442_1_0_1"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="PhylomeDB" id="B0XPZ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="279"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="377" mass="42771" checksum="1823D59C6E5C9889" modified="2008-04-08" version="1">MSRLPSVSSLMSPPESKPFENFNTSFSPYSTSQDYCSFVHGMRLPPISGERKRTQSEMDLPSPPVTPYTGNKKRKSEVSEEIERDVVLGSSRDPVLFPHHDSLTDVATDEPLFGQILPAPAEALMEQHIDSHMARFDNKVNKPTRDEYILALSCVPVVSAQYNRNPAAWAKEERETLERQLFMMNRHRPQSMDANLKKIAPAPSKRAVVTQPRAQRTPRAKRSPRSTPHQKAHEFFDLPTQTSARPPRGIGTNRDDTDYTSIQDFSPSPETLGGNAKALKADWKGQMLDLSQDPDRHLLSPAELSLASTLRLSCATYLCSKRRIFEARVRALRIGKEFRKTDAQQACKIDVNKASKLWTAYDRVGWFDSEHFRQYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQB1</accession>
    <name>B0XQB1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase inhibitor I78 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_009330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009330"/>
    <dbReference type="HOGENOM" id="CLU_162852_1_1_1"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="PhylomeDB" id="B0XQB1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9163" checksum="BBF29701C60A20D1" modified="2008-04-08" version="1">MPLVVPGINSDMGSDKNEWLSKLVGKKISDSTSDVTTFAKKDLPEHHRVLRPGDAMTMDHRPERLNIHLDEEDKVKDVHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQD8</accession>
    <name>B0XQD8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA splicing factor (Prp31), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_009600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009600"/>
    <dbReference type="HOGENOM" id="CLU_026337_2_0_1"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="PhylomeDB" id="B0XQD8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="172"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="519" mass="55637" checksum="918C05B1E0570496" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQF4</accession>
    <name>B0XQF4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 19">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_009760</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 19"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009760"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_0_1"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="PhylomeDB" id="B0XQF4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 19 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP56268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="417" mass="44761" checksum="7163332910C70B91" modified="2008-04-08" version="1">MSLTNKLAITDVDLKDKRVLIRVDFNVPLNEKKEVTNPQRIVGALPTIKYAIEQGAKAVVLMSHLGRPDGKKNPKYSLKPVVPELEKLLGKSVIFTEDCVGKEVEETVNKASGGQVILLENLRFHPEEEGSYKDEEGKKVKADKEKVAEFRKGLTALGDIYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELEYFAKALESPSRPFLAILGGSKVSDKIQLIDNLLPKVNSLIITGGMAFTFKKTLENVKIGNSLFDEAGSKTVGDIIEKAKKNNVKIVLPVDYITADKFSADAKTGYATDEEGIPDGYMGLDVGDKSVKLYKETIAEAKTILWNGPPGVFEMEPFANGTKQTLDAAVDAAKNGAIVIIGGGDTATVAAKYGAEEKLSHVSTGGGASLELLEGKELPGVAALSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQQ8</accession>
    <name>B0XQQ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_010820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQQ8"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0XQQ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="548" mass="60918" checksum="4B93C9DEB27384FD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQU4</accession>
    <name>B0XQU4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_011180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011180"/>
    <dbReference type="HOGENOM" id="CLU_063954_1_0_1"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="PhylomeDB" id="B0XQU4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="3">
        <location>
            <begin position="175"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="264" mass="29188" checksum="CD65D5D8F40CE789" modified="2008-04-08" version="1">MQALNFSPDTRQLPVLLATTNSPLPILLLLITCLPSLLLAAHYIRKDYHAFLALGPGGTPSTPTGYARICILRLFTVRDPLSPPSTPPSLHPKHGQLPSSFPTRAGPRPTVAGIAPHRQTTQRASKTMYVTLSNRIRELVNAHPSTLRAATSCFEKHSTGIFCMAGPAQRHACDGEVCHSHPVDGSLHLTLHPADVRAVLEKKWGERHPLAWDDGGGQWCWWWWAKSVPPGFVMIYAPRDERELEVVMDIIRAAVWWVGGTELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQZ5</accession>
    <name>B0XQZ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_011700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011700"/>
    <dbReference type="HOGENOM" id="CLU_556630_0_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="B0XQZ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="508" mass="57832" checksum="BCB42877CF3B7A3F" modified="2008-04-08" version="1">MEAEQDPSTPFSAKENGWQYRSLIHRILIFSQNLLMHAARCGDIVQLRSLLYGVSPDIRDSTGRTAFSWAASYDLTQSPETYNNCNLVLQFLLDRGANPDLADYHGETPLHWAVKGGDYRMVDLLLQKNVESDLPDSRSRTPLSRAAERGYDRVVEVLLTKGKADADYKDARGRTPLSWAAENWHLETATILVNHGASVDIHDREGQLPLWWFISNTIKRTAMEQQYQPGKGDYLQKWLTLLGPKHGVEPMTKARRTFLSWACEKGDQELVKHFLQTAWADPNSIDRYRKTPLIYALEWNHYEIADMLISGVKTGTILKRDIVSLRIMIQESRSRLLKPFLERYKPSLEHEDEYNTIPLMRIALQQADRATVAVLLEHRASIQGLENVDWFGPCSTVKSSADLVFLNDMRTGHGHNAIPLMKMAIEEGDRAAVAALLDQRERMLRIKEQENDDDSDIGQRSREVTAVAVDIAVARNGTKTAQWLIQGELEAHIRNMPKTADETHLMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR35</accession>
    <name>B0XR35_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mannosylphosphate transferase (Mnn4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_012100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012100"/>
    <dbReference type="HOGENOM" id="CLU_052528_0_0_1"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="PhylomeDB" id="B0XR35"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760089" evidence="5">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="105"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="300" mass="35451" checksum="DFF0916A3781CD18" modified="2008-04-08" version="1">MIPRILRLIVLAIWSAEAVASPVRSSDQDHSNVNHGKILTHEPEYDPLWEKYGLNKSQEFKYFHEPGNDDILGHYDTRFFTEPVPDKERSETMTHMIRAYLNFFNERGLETWIAHGTLLGWWWNGKVLPWDWDIDTQVLDTTLLRLADQFNQTVVHYTAADSSVERSYLLDVNPWARQRERGQGLNIIDARWIDRRTGLYIDITGLSRLEPEKPSLWQDKNDHKYQTGDIYPLRKTTFEGVPAKIPFDYDSVLIKEYTQEALTSTKFHNHTWYPDLEQWVSDHDEIAKGKLNDDRQYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRJ0</accession>
    <name>B0XRJ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002640"/>
    <dbReference type="HOGENOM" id="CLU_123960_0_0_1"/>
    <dbReference type="OrthoDB" id="5421770at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="188" mass="19492" checksum="82D83DC5989B223E" modified="2008-04-08" version="1">MSANPETNGGDISSADAHFIIECLKNLNGSKQVDIGKVATVFKYSNVLSARNRLRNLSKRYGFPNLECRFPSTPTKAGKAGAIVEAAKDDTAGDDPSSSGETVQSTPSKPARKPAGRKGAKVNSKPIPATGPVSADGSTSPSKKRGPRGKGKLAVAQEAAVMESVEIPVKKDNGNVKMEDGGGIKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRJ9</accession>
    <name>B0XRJ9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall proline rich protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_012940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012940"/>
    <dbReference type="HOGENOM" id="CLU_007264_0_0_1"/>
    <dbReference type="OrthoDB" id="5406427at2759"/>
    <dbReference type="PhylomeDB" id="B0XRJ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="916" mass="98098" checksum="4A6479513BC15487" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRM5</accession>
    <name>B0XRM5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_013200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013200"/>
    <dbReference type="HOGENOM" id="CLU_001493_1_0_1"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="PhylomeDB" id="B0XRM5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="13"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="691"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP56609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1064" mass="122391" checksum="C9B11533CBB53C7C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRT6</accession>
    <name>B0XRT6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell cycle control protein Cwf15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_024780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024780"/>
    <dbReference type="HOGENOM" id="CLU_068312_0_1_1"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="PhylomeDB" id="B0XRT6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP54422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="240" mass="27886" checksum="71AD38C4AB327D58" modified="2008-04-08" version="1">MTTAHRPTFDPAQGKEALRGPAYHQRLLPAYTHLKTRQLGQGSEAEVRQRDLRAELLQAEAAHFAKKNGVPINEPVTESAAPKRLLEGGPPDGANEAEEEDPEAKRRRILEETREIDADSEGSEDDSSEEESDDEDEAAELMRELEKIKRERLEQKEKEERERAAKEEEQREYDIARGNPLLNPQDFNLKRRWDDDVVFKNQARGTEEKRGKEFVNDLLRSDFHKRFMVSQLFERIYERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS76</accession>
    <name>B0XS76_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_026210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026210"/>
    <dbReference type="HOGENOM" id="CLU_007003_8_2_1"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="PhylomeDB" id="B0XS76"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="611" mass="68775" checksum="A51F2D8A3223D2F1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS80</accession>
    <name>B0XS80_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_026250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS80"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026250"/>
    <dbReference type="HOGENOM" id="CLU_031403_1_0_1"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="PhylomeDB" id="B0XS80"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="435" mass="49137" checksum="477CB4360EA7C678" modified="2008-04-08" version="1">MVLTKENAMIGIIGLGDMGKMYAQQLSLAGWRVNACDLPQNYERLKEEFASQQGVTILPNGHLVSRISDYIIYSVEAAVIDRVVAQYGPSTKVGAIVGGQTSCKAPELAAFEKHLPPDVEILSCHSLHGPQVNPKGQPLVLIQHRASDESLRFVEEVFSSFGSKYVYLTGEMHDRITADTQAVTHAAFLSMGTAWQANNQFPWEMSRWVGGIENVKINITLRIYSNKWHVYAGLAILNPAAKEQIRTYAQSVTELYKLMIGGQREELKRRVKAAGAAVFKDGTEGQELLLKDEVLDRFSLSNRPREYHPPNNHLSLLAIVDCWSKLGIVPYDHMICSTPLFRLWLGVTEYLFRNPKLLDEALDTAIDDKTFRSDDLEFTFAARAWSDCVSFGDFESYRDRFERIQQYFAPRFPEAVKLGNEMMKTILERTATETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS84</accession>
    <name>B0XS84_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_026290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026290"/>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="PhylomeDB" id="B0XS84"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="143" mass="15972" checksum="A52638281FB133A0" modified="2008-04-08" version="1">MASVPSVQCFGKKKTATAVAHCKQGKGLIKVNGQPLSLVQPEILRFKVYEPLLIVGADKFAGVDIRVRVSGGGHTSQIYAIRQAIAKSIVAYYQKYVDEHSKNQLKQAFVQYDRTLLVADNRRTEPKKFGGRGARARYQKSYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-11-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS89</accession>
    <name>FFMA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type transcription factor ffmA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Favors fermentative metabolism protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Regulator of FLO11 protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffmA</name>
        <name evidence="6" type="synonym">rfeC</name>
        <name type="ORF">AFUB_026340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Nat. Biotechnol." volume="21" first="150" last="156">
            <title>Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.</title>
            <authorList>
                <person name="Askenazi M."/>
                <person name="Driggers E.M."/>
                <person name="Holtzman D.A."/>
                <person name="Norman T.C."/>
                <person name="Iverson S."/>
                <person name="Zimmer D.P."/>
                <person name="Boers M.E."/>
                <person name="Blomquist P.R."/>
                <person name="Martinez E.J."/>
                <person name="Monreal A.W."/>
                <person name="Feibelman T.P."/>
                <person name="Mayorga M.E."/>
                <person name="Maxon M.E."/>
                <person name="Sykes K."/>
                <person name="Tobin J.V."/>
                <person name="Cordero E."/>
                <person name="Salama S.R."/>
                <person name="Trueheart J."/>
                <person name="Royer J.C."/>
                <person name="Madden K.T."/>
            </authorList>
            <dbReference type="PubMed" id="12536215"/>
            <dbReference type="DOI" id="10.1038/nbt781"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="MBio" volume="12" first="0" last="0">
            <title>Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus.</title>
            <authorList>
                <person name="Liu Z."/>
                <person name="Raj S."/>
                <person name="van Rhijn N."/>
                <person name="Fraczek M."/>
                <person name="Michel J.P."/>
                <person name="Sismeiro O."/>
                <person name="Legendre R."/>
                <person name="Varet H."/>
                <person name="Fontaine T."/>
                <person name="Bromley M."/>
                <person name="Latge J.P."/>
            </authorList>
            <dbReference type="PubMed" id="34006660"/>
            <dbReference type="DOI" id="10.1128/mbio.00863-21"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2022" name="MSphere" volume="7" first="e0093821" last="e0093821">
            <title>Aspergillus fumigatus ffmA encodes a C2H2-containing transcriptional regulator that modulates azole resistance and is required for normal growth.</title>
            <authorList>
                <person name="Paul S."/>
                <person name="Bowyer P."/>
                <person name="Bromley M."/>
                <person name="Moye-Rowley W.S."/>
            </authorList>
            <dbReference type="PubMed" id="35138125"/>
            <dbReference type="DOI" id="10.1128/msphere.00938-21"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Transcription factor that acts in coordination with atrR to regulate the expression of the ABC-type multidrug transporter abcG1 and thus plays a role in azole susceptibility (PubMed:35138125). Regulates the expression of genes involved in fermentation (PubMed:34006660). Is able to promote expression from the yeast FLO11 promoter (PubMed:12536215).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Reduces the growth rate, impairs the production of abcG1 and leads to increased susceptibility to itraconazole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS89"/>
    <dbReference type="EnsemblFungi" id="EDP54575">
        <property type="protein sequence ID" value="EDP54575"/>
        <property type="gene ID" value="AFUB_026340"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014245_2_0_1"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="PhylomeDB" id="B0XS89"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000459085" description="C2H2-type transcription factor ffmA">
        <location>
            <begin position="1"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2; degenerate" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12536215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="34006660"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="35138125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="12536215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="34006660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="35138125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="34006660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="493" mass="52786" checksum="66900E4602F3364C" modified="2008-04-08" version="1">MPMPQYTMQPQYPVSQPHTLPPLQPHHSQSPAPHSYMGQPPYRPDLSRYPASTHDVYASSAAPIMPHTTVGSLPPSTFLSHHNHQAQAQQSQHYPPPPHNVLPPASSAQTYPQPIAPAPPRDRRPDFNGMPSGAFSYPDGKASPWMNPDPVAAANGAGAYGAKEPPRTQVVGSQGRRGILPSVPGRVAPVTNGVNGTAKNTTIPAKDADGKFPCPHCNKTYLHAKHLKRHLLRHTGDRPYMCVLCKDTFSRSDILKRHFQKCSIRRGNPTGATHLSHPQAHLKRSQAQAAANTAKSLQEEVSSTVPPSNGIAGATFSEGAVNGNGLGAGRPGFTDQQPLGFTMQSVNGLGRGQPDDAYAHGQAHQRASWMATPKQNPYLVQPGTEAPNQQLNVDRPTLEQAKPSVVDPKRPMMPGPDPNHGGGLDWTSMFQAGASDGYINQVFPQSMASGQEPIQAQVETERKFYPTTTTAGPQEGGMNGLYLASTTLGGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSC7</accession>
    <name>B0XSC7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_026720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026720"/>
    <dbReference type="HOGENOM" id="CLU_074889_0_0_1"/>
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    <dbReference type="PhylomeDB" id="B0XSC7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="188" mass="22067" checksum="EE1A751BB2C5B618" modified="2008-04-08" version="1">MDVPEPEQTPFTAVTAQTSKLARQYQTSLDALTPYTTYRWIGTVVLLLIFFLRIILAQGWYIVAYTLGIYLLNLFLLFLQPKFDPSLTQDEGLEDGDASASLPTKQDDEFRPFIRRLPEFKFWHSATRAIAIGFVCSWFPVFDIPVFWPVLVVYWIILFILTMRRQIQHMIKYRYVPFSFGKTRYGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSK5</accession>
    <name>B0XSK5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_027520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027520"/>
    <dbReference type="HOGENOM" id="CLU_090091_2_0_1"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="PhylomeDB" id="B0XSK5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 SIN3 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="176" mass="19433" checksum="DB333A0A26CA0A91" modified="2008-04-08" version="1">MSSTSSREVKVSTAVANVTSAPANPGDQADDLPKIQWSEMSLDFLHSYRHAYKLSCPSAFSSDYSRILLSQGIGLRSPTSIAAQRAKIQQQNEVNGTNGITGRTHHRKDHGLGPPEEKTALNRTVGQGRVSKTQLATAVRKHFNSAALAEQEAIARFLYKVREEGRGRQFRLRFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSR0</accession>
    <name>B0XSR0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Catalase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_017280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSR0"/>
    <dbReference type="SMR" id="B0XSR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017280"/>
    <dbReference type="HOGENOM" id="CLU_010645_0_0_1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="PhylomeDB" id="B0XSR0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000014">
        <property type="entry name" value="Catalase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF13">
        <property type="entry name" value="CATALASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="9">
        <location>
            <begin position="60"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="573" mass="64356" checksum="B5AA1788961F9451" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT10</accession>
    <name>B0XT10_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF726 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_028480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT10"/>
    <dbReference type="ESTHER" id="aspfu-q4x0n6">
        <property type="family name" value="Duf_726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028480"/>
    <dbReference type="HOGENOM" id="CLU_007407_1_0_1"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="PhylomeDB" id="B0XT10"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="629"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="683" mass="73845" checksum="18A8E2B0D706E747" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT97</accession>
    <name>B0XT97_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_028660</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028660"/>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="PhylomeDB" id="B0XT97"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070156">
        <property type="term" value="P:mitochondrial phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="199"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="414"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP54806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="58617" checksum="8560711D74ECC194" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTH8</accession>
    <name>B0XTH8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_018630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018630"/>
    <dbReference type="HOGENOM" id="CLU_037043_1_1_1"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="PhylomeDB" id="B0XTH8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="335" mass="37901" checksum="688B2D0D1E80C0A4" modified="2008-04-08" version="1">MKYLPIPDLEDVANSLNFDTDDCHIVGGCDLYTTKAARADRKLYKNIEQSLEAQYESVLRLSASLSPPNASDAAASLNLSRSSPFGPLSDHSSRRTFAYLIATLNASHPDYDFSHVLRPSDFRRERSLKRVMNTVDSTLFNLRPRESIDMSPPSPATISGSYNSAASHIWGPRMWRTIDEHMSLKECSYYSYSPDEDPSDADDGAIWSLHYFFFNRLRKRVCYLYIRAIPILSHTPEEGDGLPTTPTGKRTFEDVDVSRYMTPDLVGSSKRARYWLGNRAKLEIESEEEGSSPPTRPVVDEYDNYVLSDEEFRSRSGSKGTVRAMSEEIADQMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTJ3</accession>
    <name>B0XTJ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI anchored protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_018780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018780"/>
    <dbReference type="HOGENOM" id="CLU_023112_0_0_1"/>
    <dbReference type="OrthoDB" id="5382170at2759"/>
    <dbReference type="PhylomeDB" id="B0XTJ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760163" evidence="2">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="85"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="366" mass="39849" checksum="B621022CB7AAC04C" modified="2008-04-08" version="1">MDVVVFFILALTVLENVSAATVRSLSREAQPFNFPKARRLSAAVSRSKLESRAELASNLLRREASFDFLHGDQDPHSVFVATLDVKSKSPILALEELDDSVQDVICKESQVDILFGSIEQVRSVHRGLEQIDGFILVTSHSGCNPDGARSTYRVNKVVIDPTRNVLSLGKSDCGWQDAFHTTRVSFSRRHPSEVRRRSNTPTKRQQQSQSEPPEQTKTMGGSTETPTVTFPAPSATSGLASTSAKELNEHYVDRKIFPPDIPAADMLLPSGLTVSCKNCSLEGNIVLDKGSFEISGSDGLIDAVNSTIAFFDHGSIEVIANGLFAQIELEFDLSASQDLGSFTAQLPAIPLIPFEVLFPESLCLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTN2</accession>
    <name>B0XTN2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_029330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029330"/>
    <dbReference type="HOGENOM" id="CLU_030988_15_0_1"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="PhylomeDB" id="B0XTN2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="157" mass="18033" checksum="8767DCB20E2E255B" modified="2008-04-08" version="1">MFAGKRLSKELLKMKEHLPPGISIVKDDNLEEWQMDIKVLDDNPLYKDQTYRLKFTFGSKYPIEPPEVQFIELPSTSDTPRPIPMHPHIYSNGIICLDLLGSAGWSPVQTVESVCMSIQSMLTANNRNERPPGDAEFVSYNKRRPRDIAFMYDDDNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-04-22" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTT5</accession>
    <name>NCTA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NCT transcriptional regulatory complex subunit A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Negative cofactor 2 AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nctA</name>
        <name type="ORF">AFUB_029870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="427" last="427">
            <title>The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Furukawa T."/>
                <person name="van Rhijn N."/>
                <person name="Fraczek M."/>
                <person name="Gsaller F."/>
                <person name="Davies E."/>
                <person name="Carr P."/>
                <person name="Gago S."/>
                <person name="Fortune-Grant R."/>
                <person name="Rahman S."/>
                <person name="Gilsenan J.M."/>
                <person name="Houlder E."/>
                <person name="Kowalski C.H."/>
                <person name="Raj S."/>
                <person name="Paul S."/>
                <person name="Cook P."/>
                <person name="Parker J.E."/>
                <person name="Kelly S."/>
                <person name="Cramer R.A."/>
                <person name="Latge J.P."/>
                <person name="Moye-Rowley S."/>
                <person name="Bignell E."/>
                <person name="Bowyer P."/>
                <person name="Bromley M.J."/>
            </authorList>
            <dbReference type="PubMed" id="31969561"/>
            <dbReference type="DOI" id="10.1038/s41467-019-14191-1"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH NCTB AND MOT1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DNA-BINDING</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B (PubMed:31969561). The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter (PubMed:31969561).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms the NCT transcriptional regulatory complex with nctB and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Results in a reduction in growth rate (PubMed:31969561). Leads to a multidrug-resistance phenotype, including the azoles (itraconazole, voriconazole and posaconazole), as well as the salvage therapeutic amphotericin B and terbinafine, an agent used in the treatment of chronic and allergic disease (PubMed:31969561). Also leads to transcriptional derepression of cdr1B and its over-production (PubMed:31969561). Also results in a notable increase in the immunogenic properties of Aspergillus fumigatus, but does not result in loss of virulence (PubMed:31969561).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTT5"/>
    <dbReference type="SMR" id="B0XTT5"/>
    <dbReference type="EnsemblFungi" id="EDP54927">
        <property type="protein sequence ID" value="EDP54927"/>
        <property type="gene ID" value="AFUB_029870"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029870"/>
    <dbReference type="HOGENOM" id="CLU_045277_6_2_1"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000449613" description="NCT transcriptional regulatory complex subunit A">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="31969561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="31969561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="247" mass="27155" checksum="0B46EBF5840767C6" modified="2008-04-08" version="1">MTDQDSTYRPRSPDLSTFQSSIPPAVNSPIYPLASPLAHRASYDASPFFAPQYQQPPAPLGRVPQQYIPPFVDPNSPLSPDMARRSSRLARATEVAPMPEVSYAQPVLSEEPQQLPPPPPQPNPVASIEVKTKFPVARIKRIMQADEDVGKVAQVTPIAVSKALELFMISLVTKAAKEARDRNSKRVTATHLKQAVVKDEVLDFLADIIAKVPDQPAGGRKHDDDGSDQNEQPKRKRGGRRPKDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTX9</accession>
    <name>B0XTX9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_019470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019470"/>
    <dbReference type="HOGENOM" id="CLU_048020_0_0_1"/>
    <dbReference type="OrthoDB" id="3533623at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="451" mass="50877" checksum="BC5E1D068F667BED" modified="2008-04-08" version="1">MAHLEERPSSLDGSAWTWIFDHCLRYPETYEIPLRTMYALNCNPTRQPSSGTRTPETAFSNRSSSSSKTSVSSQDFILDPAADFRAQLTHHIARMPSQPCSLPPSFVTSFLRRCFAPQLDEVDFPQALTALDYLKDLENRRRREVAAALQRLNIHPDDLKEKTELAKKYPGVLTWIESINVQGRKVEALYTQIYLGLRRWILINEMLLAPFNKANCIAMLNTLFPPVTEATVTPTSQLTPQILKSQRDGFFRYISAFETNGRQILDKVITQGAPEGEANGWPLVREALDKYLRIANEIIDECVLVNGPSSFEEREDPAPRGHKSRKVDSGISLESNDKLPPPSIRSGNGNEDILDKPLPPPPEKLPHFKSGGSALDRLARELRKLGDVGKAKSLKKMRSTSALGIRPENLPSHAPDEESYFDTDELKRRNLIWEATTRKRTHSKQSSSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU21</accession>
    <name>B0XU21_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cutinase</fullName>
            <ecNumber evidence="3 13">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_030040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 13"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU21"/>
    <dbReference type="ESTHER" id="aspfu-q4x078">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030040"/>
    <dbReference type="HOGENOM" id="CLU_040058_1_0_1"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122516" description="Cutinase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="199"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="328"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="366" mass="35677" checksum="5919490B4A8D6391" modified="2008-04-08" version="1">MKISATAVVLLAGLAAGAPTKTIQSKFEKRQFGTGTDGLGALASLFPTLGGGGSSTSSGLGALASLIPGLGGSSSGSGFSLPGFTLPTSIPGLGSLGSLGSSGSSGASGLSGLSGLGGLSGLNGLGSSTTGSSAEASTSGTAATSSNSNSGGALFGLLGGEFPLFPRQPSRLLRYSDHVAKRGLLGSMTENGVKNKDACQPLTFIFARGTSELGNMGSVVGPPVATKLRSLLNNKVVVQGVDYPASVEGNALLGAAGGPTMASMVKQALSQCPDTKVVVGGYSQGAMVVHNAANSLSQGQIAAAVLFGDPFKSQAVGKVDKANVKEYCAAGDPVCLNGANVIAHLSYGSDAAEAAQFLVTASGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU93</accession>
    <name>B0XU93_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_019930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU93"/>
    <dbReference type="HOGENOM" id="CLU_004134_0_0_1"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="PhylomeDB" id="B0XU93"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="807"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="377"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="728"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP53947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118516" checksum="5F6E9ECF8B34F3D8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUJ8</accession>
    <name>B0XUJ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_031140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031140"/>
    <dbReference type="HOGENOM" id="CLU_011527_0_1_1"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="PhylomeDB" id="B0XUJ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="562" mass="63168" checksum="5D8045E99E303FC4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUX7</accession>
    <name>B0XUX7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCCH zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_031790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031790"/>
    <dbReference type="HOGENOM" id="CLU_031811_3_0_1"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="PhylomeDB" id="B0XUX7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="219" mass="24790" checksum="54BB7986CD0E9817" modified="2008-04-08" version="1">MKAMKPSYRVAKFTHIFRETNIVSASASQETNARSSLTPSPVQHATSLSKTSANTTMTSNSPALSTSSRKMPKSEEFQPVVRSIRSKASSSSPPKIVERNKYGQRVDRFDIKTISKDDLARMKKLKLCNYFYLKGECPIEDCRHDHSRKLTKSEYHTLMVVARMTPCRYKFECDDPDCMYGHRCPHSEPGKRECVWGSTCRFDAAAHGVDTIIVKVTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVA1</accession>
    <name>B0XVA1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1237 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_032390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032390"/>
    <dbReference type="HOGENOM" id="CLU_023537_1_1_1"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="PhylomeDB" id="B0XVA1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760221" evidence="1">
        <location>
            <begin position="23"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="535" mass="58892" checksum="5839A450A6CA259A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWE0</accession>
    <name>B0XWE0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_024480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024480"/>
    <dbReference type="HOGENOM" id="CLU_090028_0_0_1"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="PhylomeDB" id="B0XWE0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="83"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="192" mass="21278" checksum="493844C77B2BB128" modified="2008-04-08" version="1">MFALFASIPCPSPQHLLQVETGLPAGWEVRHSNSKNLPYYFNPSTKESRWEPPSGTDTELLKVYMANYHSAPAGRPDGTAQGEGKIRCSHLLIKHRDSRRPSSWREAEITRSKEEAIEILRGHEQRIRSGEVSLGDIAVSESDCSSARKKGDLGFFGRGEMQKEFEDAAFALQPGQVSGIVETASGVHLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWR6</accession>
    <name>B0XWR6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homocysteine S-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_047060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047060"/>
    <dbReference type="HOGENOM" id="CLU_062282_0_0_1"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="PhylomeDB" id="B0XWR6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="313" mass="33680" checksum="0421F3EE3ECE8B66" modified="2008-04-08" version="1">MALPQLLSPKPFLTECGMETSLVYKDKVHLPCFSSLPLVDSDSSRKLISHYYDSYISIAAANGTGIVLDTRTWRGATPWAQPMGLSADKLLELNRAAVRLAKEARNRAVGGENNIPVVISGTMGPLRDAYVDTSELITLEDAREGYREQVEVLADAGVDMLAIMTVTNLNEAIAVVELAKEVRLPVVVSFSIESDGRLLGGRSLGSAIRTVDEKTGGSVVYYGVNCAHPVRISAALRDVPEDVRGRIGLIKGNASLKSHDELDNSETLDRGDISVFTDGFEGVLPLVPNVKVIGGCCGTDEEHLEAVAKRCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWX5</accession>
    <name>B0XWX5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endothelin-converting enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_036750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWX5"/>
    <dbReference type="HOGENOM" id="CLU_006187_4_3_1"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="PhylomeDB" id="B0XWX5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="125"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="573"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="755" mass="84606" checksum="DA8A96784B94F815" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX91</accession>
    <name>B0XX91_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_037240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX91"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037240"/>
    <dbReference type="HOGENOM" id="CLU_016815_1_1_1"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="PhylomeDB" id="B0XX91"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="407"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="626" mass="70140" checksum="21D69B3ECA207E2F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYV5</accession>
    <name>B0XYV5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_042220</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="5"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYV5"/>
    <dbReference type="SMR" id="B0XYV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042220"/>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_1"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="PhylomeDB" id="B0XYV5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="15">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP53051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="363" mass="39430" checksum="76A807E0E96722FF" modified="2008-04-08" version="1">MASYPKKKCGVLGATGSVGQRFILLLADHPFLELHAIGASNRSAGKKYKDAVRWKQTTAMSERLSNLVLRDCRADQFSDCDLVFSGLNSDVAGEIEMEFIKAEIPVFSNAKNYRKHPLVPLVVPTVNPQHLDLIPHQRKEFGLKKGFLVCNSNCAVIGVVIPFAALQAKFGPVEEVEVFTEQAVSGAGYPGVPSMDIMDNVIPYISGEEDKLENEAQKILGSLNADATAFDEQKGLTVGATCTRVGVTDGHMAFVSLRFKNRPGPSAEEVKQAMREYQSEAQKLGCPSAPREAIKVFDEPDRPQPRLDRDISKGYTVSVGRVREAAPGSYFDLRFAALSHNTVIGAAGSSILNAEVAVIKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y064</accession>
    <name>B0Y064_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Demethylmenaquinone methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_045770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y064"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045770"/>
    <dbReference type="HOGENOM" id="CLU_599975_0_0_1"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="465" mass="49575" checksum="C9CDFED9E5D8C916" modified="2008-04-08" version="1">MSKANVLRRLFALNTNTVSDALDFLELQGATFGIRPLWDCPKIVGRASTVKVGAKTDAAPTTHLITPVIEAVTTDDRILVIAGGKEGISCWGDILATAAKRRRIRGTIIDGMSRDIDGSRAVGYPVYGSGRDHDQRAYSPGAARVRNAAAGDYVIADTCGTVFVPAARIEEVLDLAERIDRRQDLMVQAVRAGKPVSEVMHDSQFEAICEESGAPPPSSGCTNHNPKKASPEDEELVALFAGSDTAAVSDALDKLGISGQACGILPLAHYQKVTVGPAFTVRYVPASDPPGSVGDFLDDVAVGDVVVIDNGGRTDCTVWGDIMTQYAGRRGIAGSVIDGVCRDVDRAISDGYPLFTTGRWMRTGKDRVQVGAVNEPVGIGKVRVNPRDIVVADANGVVVVPRDRARKVAEVARKIEKSEECIRDLIANGATLAEARNQLGYHTLQRHDKDENAATAVRVRPAGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0G2</accession>
    <name>B0Y0G2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear protein Qri2/Nse4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_046080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0G2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046080"/>
    <dbReference type="HOGENOM" id="CLU_056292_0_1_1"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0G2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30540" checksum="60A60B7BDF103758" modified="2008-04-08" version="1">MSSKLFPGDPSKVMVISKVTPEITTFSVPFSRFGLFKIGGRGTLVKLRTGSLAVISPVALTPEVQQIIASEGGKVQYIIAPDIEHHLHITTWKRAFPDAQILAPEGLYEKRKTSRSYPDDPAFDHIFTKDGKHSLSISDEFHADFEVEYMDGHGNREIILCHKPSRTLIEADLLFNLPCKEQYAQSEESPTAGLLNRAFISLLQATASPPTAHRRFAWYVLSKQDRASFAESVRRIYNWDFDRVIPCHGDVIENGGKEVFRSVFEWFLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0R4</accession>
    <name>B0Y0R4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_058260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058260"/>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0R4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="345"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP51805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="391" mass="43615" checksum="F43EAE066501E6A9" modified="2008-04-08" version="1">MAEMNAAERFALIKENLQEILNPDIIEGILAEGRNPKIYWGTSPTGKPHCGYFVPAVKIAQFLAAGCDVTILIADIHGFLDNLKAPIELVEYRAKYYEYTIRAMLQAVGVSTEKLRFVLGSSYQKSPEYVMDVYKLCSLVSEHDAKKAGAEVVKQSNNSPLSGLLYPILQVLDEQHLDCDVQFGGVDQRKLFAASTEWQPKLGYRKRAHLLNPMVPGLTGGKMSSSEEESKIDLLEAADTVRKKIRKAQAAPKEVENNGVLSFAEFVLLPASALKTGRPEFRVSRERDGLEPLVYHDIKQMQEDYKNDILTPQLLKPAVAEALVELMAPIITAFEASKEWQEITLKAYPPPEKKKKEKKQKDKGNRYPGAKTAETAELPLREIGVQEPTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0S3</accession>
    <name>B0Y0S3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">37S ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_058350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0S3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058350"/>
    <dbReference type="HOGENOM" id="CLU_104295_0_1_1"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0S3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="193" mass="20958" checksum="C6570687F02FCCD7" modified="2008-04-08" version="1">MPPFISSLALRTLRTLVQRPSLIAIPAVSRPILSRFQPVLRTPTAITAARAAGAGPITRHFSTSPFRQATYNQVRRGCRVSQRARRSRSPALVGRAQMKGVCLKTGITKPKKPNSGERKTARVRLSSGKVVTAYIPGEGHNVQQHSVVLVRGGRAQDCPGVKYHLVRGAMDLGGVASRLTSRSKYGTKKPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0T3</accession>
    <name>B0Y0T3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_058450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0T3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058450"/>
    <dbReference type="HOGENOM" id="CLU_009271_1_0_1"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0T3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="770" mass="85214" checksum="5DB33CFA9A7292C8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y124</accession>
    <name>B0Y124_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">AFUB_059350</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_4_3_1"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="PhylomeDB" id="B0Y124"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000026">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000004">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001669">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001988">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="133"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="480"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="24">
        <location>
            <begin position="672"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="21">
        <location>
            <begin position="912"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1083"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1274"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP51915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1546" mass="176183" checksum="320200BE461FA722" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y140</accession>
    <name>B0Y140_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_059520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y140"/>
    <dbReference type="MEROPS" id="C12.A10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059520"/>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="PhylomeDB" id="B0Y140"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF41">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="8">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="245" mass="27063" checksum="6C57154E4EA5409E" modified="2008-04-08" version="1">MDHLSLRRDSSQMAENNPDVMNELATKLGLSSELQFYDVYSLDEPEQLAHIPRPAMALLAIIPRTPAWERDREAEDANKEPYTGSGPDEPVIWFKQTIGHACGSIGLLHSLVNGPAADYIKPDSDLAAIRSLAIPLDMTKRAELLYNSEPFELAHKSVEQTGDSYADPTRERNGGHFVSFVKSGGKLWELEGSRKGPLERGILADDEDVLSPRALDMGLKRILKLNADGGEKNLLFSCIALARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y184</accession>
    <name>B0Y184_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_049030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y184"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049030"/>
    <dbReference type="HOGENOM" id="CLU_065623_0_0_1"/>
    <dbReference type="OrthoDB" id="3597832at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="316" mass="34398" checksum="B600EADD8052E86F" modified="2008-04-08" version="1">MVDVDALNSELDQISDQYQSLFRRLNSESQRDVQTVALSLSIALSQLYQLAIFVRGDYNKRVFNVSGILVTKVREAFEQLAHASTTALENVSTLQSENVDLLAAKMHIFEQNVKAAHDETAAKIAGYKDAISMIVPIWGIIGLIDHTKSPGSVLLEGQIGAARQAVDNAPHILDSAYRNAQASLDLLRGEQAKLELQSVILKRLGPLQSAIQSAITKAQELEKGLIPMKDSATEMVRRRNKLSSRAEDGAELSITKEESVSGILDVVELAIVEPNTAKQIKMILAELRNSWGPSPVPPAILSRLDELDGKAAKIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1C0</accession>
    <name>B0Y1C0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy protein Apg16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_059710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1C0"/>
    <dbReference type="SMR" id="B0Y1C0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059710"/>
    <dbReference type="HOGENOM" id="CLU_082752_0_0_1"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1C0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="120"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="72"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="172" mass="19213" checksum="F2E749D97F6FF8AA" modified="2008-04-08" version="1">MAHWRNEYSAALAARDRREKANVALYNASDRTSRIASTGAQGAQYLTGTGDKHTAIPAAGKSLAGPSVPDILAATRADLSEAQRARSELQARLTELSTELEKLRKRSTQDSRRIHVLESEDFQDELASLNLQLNMAEERSSRLQRENRELIDRWMARIGREAEAMNDASKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1G8</accession>
    <name>B0Y1G8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CorA family metal ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_060280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1G8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060280"/>
    <dbReference type="HOGENOM" id="CLU_015119_2_0_1"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1G8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="560" mass="61990" checksum="7038DFACF65A7BCB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y230</accession>
    <name>B0Y230_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfite oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_050720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y230"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050720"/>
    <dbReference type="HOGENOM" id="CLU_003827_5_2_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="PhylomeDB" id="B0Y230"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000005">
        <property type="entry name" value="Sulfite oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="6">
        <location>
            <begin position="48"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="254"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="379" mass="41567" checksum="6A92B628A90E19CC" modified="2008-04-08" version="1">MTMSTTPANSLEDDLYGKSPTPLNREPPVKQLVASFLTPADISYDRNHGPIPHLSADSHKVHVDGLVSTPLSLSIQQLASEFPQHEVICALECAGNRRHTMRTMLKEVQGIDWGDAAVMNCKWRGPRLRDVLLRAGVKASQEGLHVEFSCYQVKCQEDGWFGASVPLERCLGEDGDAVLALQMNDAPLPVNHGYPVRTILPGIVGARWVKWLDRITVSDHESPNFYQQHDYKVLPPAAVDQESAQPFWAQTPPMSDMPINSVVAVPEDNETVALSSSGVMEVTGYAVPHGADGPVTRVQVSVDGGRTWIDAKIEESGEGNRRWCWVLWSAAVCPEVGTGREVLSRAFDAAGNVQVEHSQWNLRGVGYNGYGRAQNLTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2C3</accession>
    <name>B0Y2C3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Splicing factor 3a subunit 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_050950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050950"/>
    <dbReference type="HOGENOM" id="CLU_027160_1_0_1"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2C3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="542" mass="62837" checksum="9A8EA69FF31121F5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y398</accession>
    <name>B0Y398_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial NADH kinase POS5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_053430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y398"/>
    <dbReference type="HOGENOM" id="CLU_008831_10_2_1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="PhylomeDB" id="B0Y398"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042736">
        <property type="term" value="F:NADH kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="302" mass="32387" checksum="6D7E94E9FF0459FB" modified="2008-04-08" version="1">MTVTLGGDGTILRASSLFATCVDVPPMLSFSMGTLGFLSEWKFAEYKRAFREVFMSGAGAGDRAPILEDQMEDGTGPTGWSSVRGKSMGSSRGARILMRNRLKVGLFTADGKPIQVRGNIPAAQDQLGTQGVYVMNEVLLHRGKEPHLAVVDVYVGGRFLTEAVADGMIISTPTGSTAYSLSSGGSIVHPLVPAVLLTPICARSLSFRPLVLPASTPITLRLSEKNRGRELEVSIDGVNLGQGMTVGTEARVWNEEMRHGKNEWHGGVPCVMRKVTGAEAHDGWVGGLNGLLKFNYPFGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3H4</accession>
    <name>B0Y3H4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_054210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3H4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054210"/>
    <dbReference type="HOGENOM" id="CLU_1695070_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="155" mass="17231" checksum="250349D6FA622362" modified="2008-04-08" version="1">MNHRPEVIPLRAHPPRHAPRARRRRRRFTPPAGGTPDPGAQRRHDGCGIRAWDANPDCWRLRLALLGDFQDVEWDRCPCEAEELGEGGGEVQGGLREVKDRTVGVEVVFDASVSSGGFRLDDVGPVGRFVRLSIVEAIVGLMIMEDAGVMESLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y486</accession>
    <name>B0Y486_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase/Carboxylesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_056880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y486"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056880"/>
    <dbReference type="HOGENOM" id="CLU_062889_1_0_1"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="PhylomeDB" id="B0Y486"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="266" mass="28037" checksum="47A05DBA6F963FF1" modified="2008-04-08" version="1">MTSKKPPSPADFPTNLTVTITPPQSPPRATHPAPPNILLLLHGLGDTAAAFTSFARALNLPETTIVTIQAPTPLPFDLGGFHWGDDVSFDPATGALDMDAGFKRSTGLLVDEVIQGVLVRKCGYRPREILILGFGQGGMAALVAAREMGEGKTQGASASASAGGAAEDTSLSGAISIGAPYPLSGSTVGAKNRTPVLLVGGREPTAVSDGAIRRTKQVFEFVEVHQYARKGDGMPRNREEMMPVMQFFARRLRSWQGVPEGSVEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4E9</accession>
    <name>B0Y4E9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">67 kDa myosin-cross-reactive antigen family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_057580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057580"/>
    <dbReference type="HOGENOM" id="CLU_024043_2_0_1"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417:SF2">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="606" mass="68317" checksum="696B07D549342B51" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4I7</accession>
    <name>B0Y4I7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter (Mch2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_069230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069230"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4I7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="518" mass="55979" checksum="197B0F0E4E359707" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4M6</accession>
    <name>B0Y4M6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_069620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4M6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069620"/>
    <dbReference type="HOGENOM" id="CLU_065434_0_1_1"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4M6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39291" checksum="E06AE055A634C523" modified="2008-04-08" version="1">MYFPRNHRYHKVLLYLMALELPFTIVILTLTGIASHNLYRTKLWQDGADNGFNSSPDEQLYAAANYRPYKVPTVWSELYVFLVACLSFCFFLFSSFLVHLVPKPERIVADAGWGCSITDYNLVIGVLSTFFLITKVPIHFLRLFYPPLSVIVHGGLVAVYIVSARYQAGPDMSDPAHPQPGAPWYITKKCTVAANKNNINYCRQSKALFAFTIIIIVLYFVEFVLSIHSCVLTPEERAERLEKAEEKRTWKEYEEAVLKSPAMIPMSPAYPPQGMPAMTPRSLAFNRLGGDNSSDLPLREYFGGANPRHSVQQESSAETLASGQYAQTGAAAQSQPQMYFPPPPKKAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4S2</accession>
    <name>B0Y4S2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endosomal cargo receptor (Erv25), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_070080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4S2"/>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4S2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758630" evidence="8">
        <location>
            <begin position="27"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="266" mass="30039" checksum="BA691624B7C4763D" modified="2008-04-08" version="1">MGSSPQSSTRALLGLLFLLLVQLSSALKFDLHASSGHNERCIRNFVFKDQLVVVTAIVSGQRGDGQVVNMHIKDALGNDHGRPKDIAGETRQAFTSVADTAFDVCFENKLVSHHGVANPYKSVELDVEIGADARDWSSVQAAEKLKPVETDLRRIEEMVAEIVNEMEYLRAREQKLRDTNESTNERVKWFAFGTMGMLVGLGVWQVVYLRAYFRYVDFPVSWRVDGVVANCCSCCEQVEASYLRSSRVVFWSPLVMWTRLSWLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4W2</accession>
    <name>B0Y4W2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_070510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070510"/>
    <dbReference type="HOGENOM" id="CLU_099296_0_0_1"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20744" checksum="2310B1BAE4ABA5F5" modified="2008-04-08" version="1">MVVFVDYDHDAFPRAHEGTYQAYLQPDKPALSKLKAADSDLPTHHENDHSMHDHAKNDGSHKIVNRNGFSAALNCYPIVKEIARQVDLNTLYALSRTCRQFHANLAPYRHQLVKQTLRCENEYVETLSDLLDGRAAIPDSTGQGQELHHQNPSKKYPQRSRSSPMYYLPYSTLGRPSYPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y542</accession>
    <name>B0Y542_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_071320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y542"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071320"/>
    <dbReference type="HOGENOM" id="CLU_1366592_0_0_1"/>
    <dbReference type="OrthoDB" id="4721928at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760440" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23314" checksum="06030F5195548915" modified="2008-04-08" version="1">MKVFSSILVLLFAIFHLCLAEDHPDRFPDQKQVDKDNYEAVTLAAAQKGVQLEHGKRYAFREKWAPAYGEYMCLPDYSHVRLIVGQFFNSNTRSGRQAFSAKAFEMISDEAETKLGQTPVGGKVESQVTENWWANHYYNYKKKEWVRVSKDSKYEFLGETTATDAYIENQGLKYAREHPTYNLAWNNCMVYTNEVWKEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5N5</accession>
    <name>B0Y5N5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_064010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5N5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064010"/>
    <dbReference type="HOGENOM" id="CLU_032156_0_1_1"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5N5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="491" mass="55531" checksum="5D2138295008C028" modified="2008-04-08" version="1">MCQCSPTWNLSTPKPIISNYYCCLIVKAQRQLTHIVLFRFPVHSFFLLHPWTKLSRVLQSPYSTMPSVDATASAPHLRVSAAKNQGDRSSTDTQPSARIPPPEQSAVEDKFFWTYTEEPHRSRRQAIIKAHPEVTRLCGPEPLTKYVVLGVVTLQICCAYLLRDTSFFSWSFWATAYIIGATANQNLFLAIHEISHNLAFRSAMANRLLAIFANLPIGLPYSAAFRPYHLTHHKSLGVAGLDTDLPTAVEAFFLDSLLGKAFFCTFQIFFYAVRPMFIYSPPFTYIHLLNLITQLSFDYALTKFCGGSLQPLLYLLLSSFLAGSLHPCAGHFIAEHYFFSRVESGGTESIEEQRKMRANSGASKQKQQPHPLDSLPPPETYSYYGPLNILTYNVGLHNEHHDFPAIPWTRLHELHRIAKEFYEPLPCHRSWVWVIWTFILDKNVGLWCRVKRAQGGRLVGGGNGRAGEEICAASPETDEEGDGWKESEIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5X5</accession>
    <name>B0Y5X5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_064920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5X5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064920"/>
    <dbReference type="HOGENOM" id="CLU_009710_9_0_1"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5X5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000062">
        <property type="entry name" value="Putative methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="55"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="454"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP50160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="574" mass="64839" checksum="9052490FAFC03E5D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y665</accession>
    <accession>Q4WPC0</accession>
    <accession>Q6U820</accession>
    <accession>Q9P8P5</accession>
    <name>PLB1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Lysophospholipase 1</fullName>
            <ecNumber>3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phospholipase B 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">plb1</name>
        <name type="ORF">AFUB_065820</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="FEMS Microbiol. Lett." volume="239" first="87" last="93">
            <title>Characterisation and expression of phospholipases B from the opportunistic fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Shen D.-K."/>
                <person name="Noodeh A.D."/>
                <person name="Kazemi A."/>
                <person name="Grillot R."/>
                <person name="Robson G.D."/>
                <person name="Brugere J.-F."/>
            </authorList>
            <dbReference type="PubMed" id="15451105"/>
            <dbReference type="DOI" id="10.1016/j.femsle.2004.08.019"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="Electrophoresis" volume="22" first="2812" last="2823">
            <title>Proteome analysis of Aspergillus fumigatus identifies glycosylphosphatidylinositol-anchored proteins associated to the cell wall biosynthesis.</title>
            <authorList>
                <person name="Bruneau J.-M."/>
                <person name="Magnin T."/>
                <person name="Tagat E."/>
                <person name="Legrand R."/>
                <person name="Bernard M."/>
                <person name="Diaquin M."/>
                <person name="Fudali C."/>
                <person name="Latge J.-P."/>
            </authorList>
            <dbReference type="PubMed" id="11545413"/>
            <dbReference type="DOI" id="10.1002/1522-2683(200108)22:13&lt;2812::AID-ELPS2812&gt;3.0.CO;2-Q"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 89-100 AND 122-131</scope>
        <scope>GPI-ANCHOR</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Glycobiology" volume="13" first="169" last="177">
            <title>Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins.</title>
            <authorList>
                <person name="Fontaine T."/>
                <person name="Magnin T."/>
                <person name="Melhert A."/>
                <person name="Lamont D."/>
                <person name="Latge J.-P."/>
                <person name="Ferguson M.A.J."/>
            </authorList>
            <dbReference type="PubMed" id="12626404"/>
            <dbReference type="DOI" id="10.1093/glycob/cwg004"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 90-98</scope>
        <scope>STRUCTURE OF GPI-ANCHOR</scope>
    </reference>
    <comment type="function">
        <text>Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Lipid-anchor</topology>
            <topology>GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Induced by lecithin.</text>
    </comment>
    <comment type="PTM">
        <text>The GPI-like anchor contains a phosphoceramide lipid group. The anchor position has not been determined.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5"/>
    <dbReference type="EMBL" id="AY376592">
        <property type="protein sequence ID" value="AAQ85122.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y665"/>
    <dbReference type="SMR" id="B0Y665"/>
    <dbReference type="Allergome" id="8989">
        <property type="allergen name" value="Asp f LPL1"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="B0Y665">
        <property type="glycosylation" value="18 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP50250">
        <property type="protein sequence ID" value="EDP50250"/>
        <property type="gene ID" value="AFUB_065820"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065820"/>
    <dbReference type="HOGENOM" id="CLU_014602_0_0_1"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="PhylomeDB" id="B0Y665"/>
    <dbReference type="BRENDA" id="3.1.1.5">
        <property type="organism ID" value="508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF62">
        <property type="entry name" value="LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000372611" description="Lysophospholipase 1">
        <location>
            <begin position="21"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000372612" description="Removed in mature form" evidence="1">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="2">
        <location>
            <begin position="47"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-like-anchor amidated serine" evidence="1">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15451105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="633" mass="68144" checksum="277A47E29FD74796" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6C8</accession>
    <name>B0Y6C8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_066480</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6C8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066480"/>
    <dbReference type="HOGENOM" id="CLU_116822_0_0_1"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6C8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP50313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="157" mass="16819" checksum="2457F4A154A7EE2A" modified="2008-04-08" version="1">MASSRVFASRLASQMAATTKVARPAARLQLAPKRTFTTQRKTALPMTPFQTIKRQQPSLIQANARQVFANVQSRRQYSSEIADAMVQVSQNMGMGSAAIGLGGAGIGIGLVFGALLLGVSRNPALRGQLFSYAILGFAFVEAIGLFDLMVAMMCKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6I6</accession>
    <name>B0Y6I6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Toxin biosynthesis cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_067090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6I6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067090"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6I6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="534" mass="61988" checksum="0010CFB5FD2110D5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y755</accession>
    <name>B0Y755_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">CFEM domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_072620</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y755"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072620"/>
    <dbReference type="HOGENOM" id="CLU_063084_1_1_1"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760751" evidence="17">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="99"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP49236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="198" mass="19444" checksum="B3D4A323496B8613" modified="2008-04-08" version="1">MKFFSVSLALAACLSMAAAQGLDGLPDCAKSCATNSIPASCGLDVKCICTDSSFISGISCCVLQSCGPDQQQEDAHPFFPTAAVEFANRICKTAGVTNMPQSPSCANTTQSATGTASKSSTATSGSSTESNASQTAATATTSTTSPTSPTSPTSTTGSTTSSAASTTNTTTGAAVTQHKDIGLIALAGAALAAFGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7B4</accession>
    <name>B0Y7B4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Purine-cytosine permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_073220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7B4"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7B4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF16">
        <property type="entry name" value="PURINE-CYTOSINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="528" mass="57889" checksum="EFE4BA2BBF565D2A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y805</accession>
    <name>B0Y805_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_075660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y805"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075660"/>
    <dbReference type="HOGENOM" id="CLU_000022_60_3_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B0Y805"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000110">
        <property type="entry name" value="Nonribosomal peptide synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF12">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE IVOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="672"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1135" mass="125704" checksum="3E00F42480BD7E24" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y817</accession>
    <name>B0Y817_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 oxidoreductase GliF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_075780</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y817"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075780"/>
    <dbReference type="HOGENOM" id="CLU_022195_0_2_1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="PhylomeDB" id="B0Y817"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000059">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP49548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="504" mass="56541" checksum="604B15BD9A4BDA50" modified="2008-04-08" version="1">MDQVYLPQSVRTAVAVSFGVGLLYWVYRLLLQKTKSLKALDLPVLQSVGDQDIVKTLEEGHAKYPDTPFALGVPGQQLVVLPVSEIDTVKALPENQLSIKKHHYNQFLGEYSYMGTKADEFDDAMRYLLVRNTPAVLASFTAEIDYAMSTVLQVPPNSWTRVKPRSIMPKVATILSGRAFVGLPLSREPDWIESNVNYTQDVSRAWMVLRFYPHWIRPLVAPFLREVKTLEQNKALIGRKIAKLLADQEAQKLSPAQEKIPGGDMIDWFKSRYQAQGKTATAQQLTRDQLLATFASIYNLSNALTYVMFDLAANPAAVDELREELDQVLGPNVGAESIDKTALPRLIKLDSFVRESQRLSPTSLVNIPRIVTDPNGLRLKTGHVIPPGYLVMVRAQPINQSPTLYPNPERFDAFRFARLRQQGGANENRWQHTSTGADNINFGHGIWACPGRFFASAEIKVVVVYVIRHYDLRLIEGRPHPKPKYGGLAIFPDAGAEVELKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y842</accession>
    <name>B0Y842_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Patched sphingolipid transporter (Ncr1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_076030</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y842"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076030"/>
    <dbReference type="HOGENOM" id="CLU_002359_0_1_1"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="PhylomeDB" id="B0Y842"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760862" evidence="16">
        <location>
            <begin position="27"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="743"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1067"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1100"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1129"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1172"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1213"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="594"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP49573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1273" mass="140399" checksum="5203B089E2C37989" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8W2</accession>
    <name>B0Y8W2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase component (GAA1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_078760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078760"/>
    <dbReference type="HOGENOM" id="CLU_007442_3_1_1"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8W2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000121">
        <property type="entry name" value="GPI transamidase component (GAA1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758756" evidence="2">
        <location>
            <begin position="19"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="622" mass="68928" checksum="7371A2A28DBF0339" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Q9</accession>
    <name>BTGE_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-glucosidase btgE</fullName>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">btgE</name>
        <name type="ORF">AFUB_081940</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
        <text evidence="1">Covalently-linked to the cell wall.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP48752" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48752.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9Q9"/>
    <dbReference type="SMR" id="B0Y9Q9"/>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000165">
        <property type="entry name" value="Cell wall glucanase (Scw11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000160">
        <property type="entry name" value="Probable beta-glucosidase btgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395131" description="Probable beta-glucosidase btgE">
        <location>
            <begin position="19"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O22317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="565" mass="58148" checksum="4D06B871D8835ACC" modified="2010-06-15" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA57</accession>
    <name>B0YA57_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_083490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA57"/>
    <dbReference type="HOGENOM" id="CLU_049611_2_0_1"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="PhylomeDB" id="B0YA57"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="363" mass="40032" checksum="5FDC97D284486E21" modified="2008-04-08" version="1">MSVGELSSGRTLSRRRNISRTISSVRCRIKAFKPTQDRPFVLGLPTGSSPEIIYRTLVQRHRTGEISFKNVVTFNMDEYVGLPRDHPESYHSFMYKHFFSHVDIPPQNINILDGNAPDLAAECASYEARIAGYGGIELFLGGVGADGHIAFNEPGSSLSSRTRVKTLAYDTILANSRFFDNDVDKVPRMALTVGIQTIMEAREVVIVATGAHKALALKKGLEGGVNHMWTLSALQLHQHPLVVCDRDATLELKVKTVRYFESIEQSGTDARTQGPPLVYRPRTYVPAPLGAGKLPHQLTPASTPSKVPKDLRINTEFQNSIEEDELTPDSMSSRLVDSAIGGLDTTLKADIMFDRMGARVVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA77</accession>
    <name>B0YA77_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_083690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083690"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="PhylomeDB" id="B0YA77"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="150" mass="16597" checksum="23614BA5ABEB7B93" modified="2008-04-08" version="1">MELFADVTPRTAENFRRFCTGESKNSQGKPQGYKNSKFHRVIKDFMIQGGDFVNGDGTGSCTIYGTPKFADENFVLKHDRAGVLSMANSGPNTNGCQFFITTTATPFLNGKHVVFGQVVDGMDIVRMIENTRTIRDKPSQDVIITQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAB4</accession>
    <name>B0YAB4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_084060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084060"/>
    <dbReference type="HOGENOM" id="CLU_006332_4_0_1"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="PhylomeDB" id="B0YAB4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758795" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="598" mass="66155" checksum="0E2804F4A57BD159" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAG7</accession>
    <name>B0YAG7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-xylulose reductase</fullName>
            <ecNumber evidence="10">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_084610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084610"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="PhylomeDB" id="B0YAG7"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF3">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="11">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP49010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="39142" checksum="A692DE582F21F7FB" modified="2008-04-08" version="1">MTVATPNQAVNQAFVLHPGGSFHYEQRAVPTLGSDRDVLVRVVATGLCGSDVHYWQHGRIGRYVVESPIILGHESSGIVVECGSKSGFAVGDRVALEPGVACNTCSHCRAGRYNLCREMRFAATPPYDGTLATYYLVPAECCYKLPPHISLRDGTLIEPLSVAVHSCRLAGDMQGKAVVVFGAGPVGLLCVAVARAFGASTVLAVDVVPSRLGSALKYGATHTYQMTPDSSEQNAEEILNKVELETGADVVLDATGAEPCLNCGIHILASGGTFVQVGLGKPNPSLPVCQICDKEIVFKGSFRYGPGDYQTAIELLHSRRIRLDGLVTHEFPFTQAEDAFQNVVSRAGIKSVIYGPGVDEHVAKATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAU5</accession>
    <name>B0YAU5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Class III chitinase ChiA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_085870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085870"/>
    <dbReference type="HOGENOM" id="CLU_007818_6_1_1"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="PhylomeDB" id="B0YAU5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000196">
        <property type="entry name" value="Class III chitinase ChiA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758809" evidence="7">
        <location>
            <begin position="20"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="31"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="334" mass="35386" checksum="5CE0FE1A5F21637A" modified="2008-04-08" version="1">MYFTTLLSALSLVAAAASALPHQLSSRASGAQNVVYWGQNGGGTVENNDLASYCTSTSGIDIIVLSFLYQYGNGNTIASGTIGQSCYISPSGQPQNCDALASAIKTCQSRGVKVILSLGGAVGAYSLSSQAEAETIGQNLWEAYGNTQGNGNVPRPFGSTFVNGWDFDIESYSGNEYYQYLINKLRSNFASDPSNQYYITGAPQCPIPEPNMQVIVTKAQFDYLWVQFYNNPGCSVNGPINYDQWVSNLANTPSANAKIFIGVPASPLGATGTSSGAQYYLQPSALASLVAEYKDNPAFGGVMMWSAGFSDANVNNGCTYAQEAKRILTTGSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAX8</accession>
    <name>B0YAX8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DltD N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_086190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAX8"/>
    <dbReference type="SMR" id="B0YAX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086190"/>
    <dbReference type="HOGENOM" id="CLU_048587_1_1_1"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="PhylomeDB" id="B0YAX8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="46"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="32697" checksum="AC2FDEA87B7E9CB2" modified="2008-04-08" version="1">MNREDVEFPTCDGLILRGWLYPGTIRGPAIVMNQGFNTPKEILLPDVAVWFQQQGVTVLLYDNRCIGASDGEPRNDVKPAKLVEDFHDALTFMARHPMVDEDKIILYGYSFSAMTALVAAGLDHRVGAAISVTPIANYDFREKEKNNVMALAMQDRVSTLAGNDPVYIPFVGDDGYNPAGWGNQYNMEQFRAFLGTSFFTNRTTVQSYYHVLAWQPYGAMRLIKGTPVMMVTPAEDTISSPADQRAVFDMIPEPNKEFDLVAGRGHMDVINGEGAEEVLQRQLAFMRKHLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB49</accession>
    <name>B0YB49_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_091560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091560"/>
    <dbReference type="HOGENOM" id="CLU_125186_1_1_1"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="PhylomeDB" id="B0YB49"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP48439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="95" mass="10689" checksum="63B67A559F973636" modified="2008-04-08" version="1">MSGRAGGGGARKTLLAPIHFIFKLLQQRTTVSIWLYEQLAFRIEGKIRGFDEFMNLVIDDAVEVKMATKTDEEKRRPLGQILLKGDNVSLIQAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBQ6</accession>
    <name>B0YBQ6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_087489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087489"/>
    <dbReference type="HOGENOM" id="CLU_2849266_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="65" mass="6782" checksum="257F370CAF15E21A" modified="2008-04-08" version="1">MEIGWGWLTAQAGAPRIVKKRATRFGSPSGLGSVVLAGTSATGPARTAAERRGALRIVESFIVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBS6</accession>
    <name>B0YBS6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_087680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087680"/>
    <dbReference type="HOGENOM" id="CLU_157370_0_0_1"/>
    <dbReference type="OrthoDB" id="4770059at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="133" mass="14105" checksum="8FAA8A0D1CA3ED52" modified="2008-04-08" version="1">MTNFHYGSIRLHGGFTDLPRAQASVHPSSSTSTGLFLPTAAKAGIGVCAGVGALLTSVFLFLWISRLRKTKANVANMNRAPGVGLPHYCNTGELRGGFPPPTISMKQTHGPPMELDNGEYSKDPGKDLPELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC42</accession>
    <name>B0YC42_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U5 snRNP complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_088830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088830"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_2_1"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="PhylomeDB" id="B0YC42"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="359" mass="39257" checksum="DB897E9A5568F1FA" modified="2008-04-08" version="1">MSGEKRPAQAAFGSSNQLVVKRKRSDGDINAGTAVVKSSSQNGTLVQAIPRTSGLDAPIMELTGHSGEVFTVRFDPTAQHIASGSMDRSILLWNTYGQCENYGVLTGHRGAILDLQWSRDSRSIFSASADMTLASWDLETGQRIRRHVGHEEIINCLDISKRGQELLVSASDDGCIGIWDPRQKHAIEYLETELPITAVALSEAGNEIYSGGIDNTIHVWDLRKKSVVYSMAGHTDTITSLQISPDSQTLLSNSHDSTVRTWDIRPFAPTNRHIRTYDGAPMGLEKNLIRASWDPKGEKIAAGSGDRSVVVWDFRTGKLLYKLPGHKGTVNDVRFSPNSEPIIVSGSSDRTLMLGELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCE4</accession>
    <name>B0YCE4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_089890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCE4"/>
    <dbReference type="HOGENOM" id="CLU_030273_1_1_1"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="PhylomeDB" id="B0YCE4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="382" mass="42122" checksum="6364B602FEE5D83D" modified="2008-04-08" version="1">MTKWAQYRGSRTSWGINVLGSFCVEIEATDGTKGFATGFGGPPACWLVHQHFERFLIGADPRDTNDLFERMYRASMFYGRKGLPVAVISVIDLALWDLLGKIRNEPVYKLIGGATRTRLHFYCTGPQPAAAKAAGFIGAKVALPHGPDEGTEGLLKNVEYLRKQRESVGPDFPLRVDCYMSLNVPYTIELVKRCEAEGINIDWWEECLSPDDFDGHALLKRAHPTIKFTTGEHEYSRYGFRKLVEGRNLDILQPDVMWVGGMTELLKISAMAAAYDIPVVPHASGPYSYHFVVSQTNSPFQEYLANSPDGMTVEPVFGNLFVNEPIPTQGYLDVSILDKPGFGLELNPAAPLISAAAILTPAPKKSLTLPAEDEKLANGATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD72</accession>
    <name>B0YD72_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_094520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094520"/>
    <dbReference type="HOGENOM" id="CLU_047843_0_0_1"/>
    <dbReference type="OrthoDB" id="4167490at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="473" mass="53440" checksum="29073992A3D1DCC0" modified="2008-04-08" version="1">MLTPIRVRGRRKKALAQNSNHAQGGKARPSGPKGGRPLMSREARLDSSQARNNKRARLWAARPSKRRKTLSLLETLPVELIEKIFLYSLNVNLPRASPSLAAAVSSERIYRVLILLGFWNDSASEAEDPDSAISRILRPLDYAPLQDDDRENLQTSVLRCRWCTMPRLLMQLSDMTNLTIQRHWVNAGIEMTRDQQESLDRFLARENDTSTYEGTDKDGNHYTLSITPFVSINIACQETDEQQTHKILSIKHFPEKLLLGASGEGFSDDHATHLEIMRVACGLSRSDHLETDVSVSRESLHQGVHIALVEHNTRALATLLKIDEYIFRSNAAVAGGLPYSIPPEHFRTAVRVARNDPALFQTLLRASAESVPADDPEITEWAMNLGDPFGHWLLDLMLRLPQQIETANANPAEGALFYLGRANGQIELARRYLRDVLNVDELPSWMEASDDLFRQWRVITTTTGRDRFVESQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDJ1</accession>
    <name>B0YDJ1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 12">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_095770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 12"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095770"/>
    <dbReference type="HOGENOM" id="CLU_013093_1_0_1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="PhylomeDB" id="B0YDJ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000070">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006215">
        <property type="entry name" value="Glyco_hydro_melibiase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00748">
        <property type="entry name" value="MELIBIASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="13">
        <location>
            <begin position="371"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP47725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="512" mass="56326" checksum="1DF138AABC656001" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDT5</accession>
    <name>B0YDT5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_096720</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096720"/>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="PhylomeDB" id="B0YDT5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000051">
        <property type="entry name" value="Pyruvate decarboxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="203"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="400"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP47819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="575" mass="64123" checksum="4BD70F7A5639F5CE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE57</accession>
    <name>B0YE57_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Velvet complex subunit laeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_097920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097920"/>
    <dbReference type="HOGENOM" id="CLU_010595_2_0_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B0YE57"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP47941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="40327" checksum="2B66ED9A642D3496" modified="2008-04-08" version="1">MMSLTSILGGSMDGIHQCSTQRSSLSRGSFLHSCDRQQCPENNKGPLGIEKEAEHKENNRTYHQFHRGKYMLPNDEEEQDRLDFLHNALLQVTGRLTHVPHPTDARVLDLGCGTGIWAIDFAEAFPDSFVVGVDLSSIQPAGHPRNCHFYAPFDFEFPWAKLGEESWDVIRLQMCGGSVVNWPSLYRRVSAHLRPDAWFEQVDIDFEPRCEVRALDGSALYNWYHNLRQATSDAARPISHQFHAIIDHLQNAGFTDIKHKHFVLPLNRWHSDLWMRHIGGWYGRAFFDSIEPLSLAPFRRILNWTPDEIQHLVTDAKSELLDPAAHTFHVLHIYIARKPTPTSMCASVESDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEA1</accession>
    <name>B0YEA1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_098450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEA1"/>
    <dbReference type="HOGENOM" id="CLU_026731_1_0_1"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="PhylomeDB" id="B0YEA1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001486">
        <property type="entry name" value="GTP binding protein, putative (AFU_orthologue AFUA_4G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="565" mass="61232" checksum="FB50D800C63F1140" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEK4</accession>
    <name>B0YEK4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyhydroxybutyrate depolymerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_099490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEK4"/>
    <dbReference type="SMR" id="B0YEK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099490"/>
    <dbReference type="HOGENOM" id="CLU_042524_0_0_1"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972:SF8">
        <property type="entry name" value="POLYHYDROXYBUTYRATE DEPOLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="454" mass="47659" checksum="36B8301B3C7B8856" modified="2008-04-08" version="1">MRGVWRYMPVYYYKCMLIPLLTFTKISIISKPQESRISLIICRTMPTVATFLGLAISGAAMASGAALGAYNVDPNSISVSGLSSGGFMSAQLGVAYSDTFKVGFGVFAGGPYDCARGQSYTTCMYNQNPSITTPVANMKSWSGNKINPVSNLQSRKIYMWTGTADTTVGPNVMSQLKTQLANFASAANVSYITTSGAAHTFPTDFDAAGDNSCSSSVSPYISNCQYDGAGAVLQWMYGPLNARNPGTLSGSIVSFSQTGEYGASGMDTTGYLYVPRACQPGSSTVCKLHVALHGCKQSYSMIGSKFVSNTGYNMWADTNDIIILYPQAVADNTMHTIWTGMPLPNPNGCWDWVGWYGANADQVGGVQMAAIVNQVARVVSGYGAGSSSSTTAATPTTTTGSITTTTTTTATVTTTAVAPLYGQCGGIGWTGPTACATGVCTAYSPYYAQCLLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEK7</accession>
    <name>B0YEK7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_099520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099520"/>
    <dbReference type="HOGENOM" id="CLU_033726_4_1_1"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF8">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="275" mass="30671" checksum="566883573E589CE0" modified="2008-04-08" version="1">MAVMSLKMQTQIANAEPKSKRIITPARRDQNRRAQQAYRQRRRERLAEKQSHAGPRELRPAPPAHASIPNITTSNRLDVARKTMPAMLTVDHFFPPHDPARNGRTEDPVRDEVPPPLFTTYTLLLAACVYNAAALGISTDQFFGEDNCMSLCSPFYRPYTAMSADPSSLLAAATGTRPAIPAHLRPTLPQILFPHHPLFDLLPLPALRAKAITFAATAPSLLDAVEFKRDIVERGGIVCSSESAGGMQPWDMRAWTVAPWFRRKWRILSQSEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0YFA0</accession>
    <name>B0YFA0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_102060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YFA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_102060"/>
    <dbReference type="HOGENOM" id="CLU_882712_0_0_1"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="PhylomeDB" id="B0YFA0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="126"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="315" mass="34997" checksum="CFC417A2A4F57B88" modified="2008-04-08" version="1">MGSMHEAGSRPAAGADMDTDRVHPEAVSDNERDFEKQDSKPEYQDAFGDEEYAEVKYKTLSWCVFSAVLIVMIAVGVQRPWHGGLNATVDTNLYKAFLAVCNIVFSFCRLFLHFSSFMDRTNKTAGHVAFFGFMAELRNPRDYPKSLFLLQGIDTCLYIIAAVVIYCYAGDDVTSPALGSASTIVKKVAYGIALPTIIIGGVVNGHVACKYIYVRMWRHSDRMHKRDLVATGSWVLIGLATWIVAWIIAEAIPVFNNLLSLVREVLVVICTMIWERVLIAPSVTAFRQPGTPDQPTEHLFPLALFVATHDPRSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM51</accession>
    <name>B0XM51_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-binding monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_000940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000940"/>
    <dbReference type="HOGENOM" id="CLU_006937_6_2_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="PhylomeDB" id="B0XM51"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF11">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="561" mass="63383" checksum="79B3B19BE067363E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM54</accession>
    <name>B0XM54_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHD finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_000970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000970"/>
    <dbReference type="HOGENOM" id="CLU_080751_0_0_1"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="70"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="300" mass="33072" checksum="C3B0116D90E922F0" modified="2008-04-08" version="1">MLRSVASQSHPGQGRAGLDRSPNDKIAGDYEALLRLLGHLVPSKVDSHVFTDNEKSCIYTNWIKAGKPHNLVCSECRSPDDLMLCETCCRSYHARCLPDPARPASTGNFYCPSCRDKRWDLTPPLINSLAASPGVSRSSTPVPPPAIMHSRTGLAAILSTQTSLQSSPVHSSPVDSQQQGAQNVLTMASSSDLMSRARHFLIQHGKFPTTQDFHPELLSNLGTMMLELESQQLLLQEIQDLREENASLRREALKTKHYYPSRMPINESALSSPSCLSPRIQTPSPDTAGKSWDRIVMDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMC2</accession>
    <name>B0XMC2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor IIIC subunit delta N-term-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_000560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMC2"/>
    <dbReference type="HOGENOM" id="CLU_011098_0_0_1"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="3">
        <location>
            <begin position="601"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="77627" checksum="4A3222C280865E61" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMH2</accession>
    <name>B0XMH2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_002720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002720"/>
    <dbReference type="HOGENOM" id="CLU_064522_0_0_1"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="PhylomeDB" id="B0XMH2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF4">
        <property type="entry name" value="THIOESTERASE-LIKE SUPERFAMILY-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="32"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="155"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33620" checksum="197309DE15EE41DC" modified="2008-04-08" version="1">MESSPSSSPFLEAVSAVSQDEETPHRFLASISQEWTTQHSVLGGFLHALMLSAAKKFIVTELGDGRFPDPVHAFVQFLSMVPPGPVSITCKFLRVSKRQCVVNVELVRSSAALWKKPELPATVGIFTYGDLSKERGLSQASDPALRIPVPPRETECVTIDDPVVDSTPVTRKLHWLAPRSANGLWGHRLGGHNREVWISFRDGSKISDCLHLALLSDMPLQPAATHQPGFYNHYALSTLCISVEFKQRPDPSTQWVMIRSNSHMVSNGRYDVNLQILAENGEILALSNHVLYISELRATKGAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMY8</accession>
    <name>B0XMY8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_003770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003770"/>
    <dbReference type="HOGENOM" id="CLU_1001061_0_0_1"/>
    <dbReference type="OrthoDB" id="4450625at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="278" mass="31541" checksum="6DE34AC98DD8FE6D" modified="2008-04-08" version="1">MKYLFFLSPLVSSLSEQGRCGPRSIRSRSTFTKPTWSNSRQGIANGEKLQKHAQRLMLPAHTQNLQRFKSIRTIIKTADPTDVISTSRSLREKGCKPIYDFSQLLEGTAKLSEFGPIFEKIDGLIRDWLGFDKVAEHRKPMADALDLIQKHRIAGNMKFFIAELKKELGIEKLALQNPKPMTPDGLPYDAYDTEKTVDQLRKSAENEADPEKKAKIEAQADGLAANIQELVIKMRSPDYKEKVKDDVKLAKFKRHQAAIFRAKNTLKLLQKIEKGGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMZ3</accession>
    <name>B0XMZ3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_003820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003820"/>
    <dbReference type="HOGENOM" id="CLU_026253_1_0_1"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="PhylomeDB" id="B0XMZ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="301"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="500" mass="58247" checksum="AAB514F6C7D935E0" modified="2008-04-08" version="1">MIRQDFQRIDPKRRATLDHKKKQFASPVYKQQDYPHRLNFYDIPPTAEITLEQFEQWAIDRLKVLAEIEACSYRNKSAAETSAHITPLLQKYLPLSSNTSSSSGALDQRLKNERQKDHYSHFILRLAFSATEDLRRRFVRAETMLFRFRFQQDDSREKRAFIESLNLDWEPVSDEERREVAEKLVSATPGLRRVDEETWYKVDWERVPELVERRAVLLSKGKAYVPGREQLSMIIAEFTARLERALELTSRALPRLDEDDRLTPILNHLSKNFGSAESVYSEGEGFVEGAPITASNIDRLSQHFPLCMRSLHMTLRKNNHLKHFGRLQYTLFLKGIGLSLEECIIFWRQSFKGFTDDEFNSRYKYNIRHAYGDVGGDVNRRGRGYPPYSCQKILNDSNPGVGQTHGCPYRHFSVDNLIGLLQSTGVHDKDVLRGVREDVEKTRYHIACNRVFEWAHKADIKRVKEDGTWGQTDLDTIVHPNTYFKRSYLLKQMGKPPKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNI8</accession>
    <name>B0XNI8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anaphase promoting complex subunit 10 (APC10), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_015300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015300"/>
    <dbReference type="HOGENOM" id="CLU_039415_0_1_1"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="PhylomeDB" id="B0XNI8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="9">
        <location>
            <begin position="154"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="388"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="454" mass="50551" checksum="2EBE3007E7F460C9" modified="2008-04-08" version="1">MPRHHLRRHPAPVPETNSDEPPQQQTSRSRLGHGSAQTQFQTPPSRNIPNIPQLHPSSGPVEMSAAAPTHPGAAAQGALFSLFGRGVSGRQRGQMMDEDDQDDEEEEDVGEEEEDVDQSYEMDHRRLDLELEEGEREFSAEEMEGMAGEELEGEDEEDELMRDRDRSPSPLPSNLREISSLASWTVSTHKPGCGVAALRHPSPTQYWQSDGPQPHMLTLHFFKLVAVVKIRVYLDFEMDESYTPTKMVFLAGMGGNDLVEFATWEGEGPCGWVDIPLEGVGGRDGGWVRRRRRKRTRARPQDGKGKGKGKGKSKGVAWPDYMFSDSENPVEYDEAAYDYDDGESTSEDDEDDPYAGNVLKAMVIQMRVTENHQNGKDTHVRGFQVFARDDDRRRMGNAPSASADGRTRRHSARRSLRGSLNDGGAEGRNPNGDADGVRVGGLEEPDWMGEPVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNQ8</accession>
    <name>B0XNQ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase PP1 regulatory subunit Sds22, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_005140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005140"/>
    <dbReference type="HOGENOM" id="CLU_044236_0_0_1"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="PhylomeDB" id="B0XNQ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="356" mass="40628" checksum="CF71F2A11A9B4324" modified="2008-04-08" version="1">MKDSKGWDGKLRVEPKATITNPEAVEDPNYSDSDAPPVEEIEADEDLLEGEDPETQEIDLVHCRIASIPALRLERFHKLQRICLRQNQITRIDFPSEIAPTLLELDLYDNLISHVKGLDEFRDLTSLDLSFNKIKHIKNISHLVNLTDLYFVQNRISKIEGLEGLTKLRNLELGANRIREIENLDTLASLEELWLGKNKITEMKNLDALSNLRIISIQSNRLTSITGLSSLKNLEELYLSHNAITDLSGLESNTSLRVLDFSNNKISKLEHISHLKNLEELWASNNELSSFEEVERELRDKEKLQTVYFEGNPLQTKGPAVYRNKVRLALPQIMQIDASKFSFFAGRALGWVADDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP04</accession>
    <name>B0XP04_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_005460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP04"/>
    <dbReference type="HOGENOM" id="CLU_024991_1_0_1"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="PhylomeDB" id="B0XP04"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000013">
        <property type="entry name" value="mRNA export factor mex67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000296">
        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="12">
        <location>
            <begin position="422"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="13">
        <location>
            <begin position="640"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP55847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="697" mass="76007" checksum="CA66F5AD16745147" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP36</accession>
    <name>B0XP36_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_005790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP36"/>
    <dbReference type="SMR" id="B0XP36"/>
    <dbReference type="HOGENOM" id="CLU_036019_0_2_1"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="PhylomeDB" id="B0XP36"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120112">
        <property type="term" value="P:UDP-glucose transmembrane transport into endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="415" mass="44851" checksum="09A1CB7673FADF00" modified="2008-04-08" version="1">MHLVPEGSESMSTQQNGSAQKPVTLNGSASTKGQAPEAPLETPGLIQLAICVLGIYASFLSWGVLQEAITTVNFPVRPPTAEEPNPPTERFTFSIVLNTIQSTFAAITGFLYLYFSTPAGKKVPSIFPTRKILFPLLLVSISSSLASPFGYASLAHIDYLTFILAKSCKLLPVMFLHLTIFRKTYPLYKYGVVLLVTLGVATFTLHHPGTSKKVAASAAKNQSGSSLYGIFLLSINLLLDGLTNTTQDHVFSSPQIYTRFTGPQMMVAQNILSTILTTTYLLVMPHLSSTGALHALLPIPIPPSTETELASAVSFLSRHPEVMKNVLGFAACGAIGQLFIFYTLSRFSSLLLVTVTVTRKMLTMLLSVFWFGHTLSAGQWLGIGLVFGGIGAEAVVQKREKQSKEQAKALTGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPB6</accession>
    <name>B0XPB6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_016760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016760"/>
    <dbReference type="HOGENOM" id="CLU_1777017_0_0_1"/>
    <dbReference type="OrthoDB" id="4425669at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757737" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="14977" checksum="686F5196DB6C8FDD" modified="2008-04-08" version="1">MRSIFLLCLALSTTVLASSSISYNKWVASLPSCMQPCFNTFFANIAETKCGKGASSSTKPSDIHCICQSGTFTSSNGYAPSIADCASALCPDAESQLQTVLGSYTQLCLSQVNSDGSVPSLGSTTAVSGLDAILVSGGIALLQCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPG8</accession>
    <name>B0XPG8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_006430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006430"/>
    <dbReference type="HOGENOM" id="CLU_025028_3_1_1"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="PhylomeDB" id="B0XPG8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="435" mass="48322" checksum="288C5CD22457B3A9" modified="2008-04-08" version="1">MATRAVVPVLVTMMLVTGVCNTILNKFQDMQCVRNCDSPDPKYRQTFEQPVVQTVQMFVGEMGCWLVIWASHIYQSFIYPRLSPNSSPLLAGGYNPVHPDDIGDEEDHTIDGPDASNHTLKRTDAEGRPYLSGRRILLLAAPACCDIAGTTLMNVGLLFVAASIYQMTRGALVLFVGLFSVLFLRRKLFLYQWIALFVVVLGVALVGLAGALFGQGHGHDMSRDDTLAIATRAVMEAREIAKTPEALKAVIGVLLIAAAQVFTASQFVLEEWILENYAMDPLQVVGWEGIFGFSITVIASIILYLTVGRTEAGRYGYFDAKEGWRQVFSNKYIAMASILIMISIGGFNFFGLSVTRTVSATSRSTIDTCRTLFIWLVSLALGWETFKWLQVLGFALLVYGTFLFNDIIRPPLKACLPRDRQERQILLPEEPIEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPM3</accession>
    <name>B0XPM3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_006890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006890"/>
    <dbReference type="HOGENOM" id="CLU_074184_0_0_1"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="280" mass="31232" checksum="46EEA2543F1DAD36" modified="2008-04-08" version="1">MASRGTSEGSNYEVFRECLSSAIVQRSDNGRPNRVAKRKALKTKRSTRKPATDGAGADTTASDSSSLPSRVNPEELAEFIDVQNPALQSHEGFLASETFPSLPADLQTLSYSSIQHDPVLADKYAASPLPRSLLESTTATIPVAVSESLSVYGLVPDPSDVPDFFSPVLSEYVASVTAAPPVWATTRTDACEICERDWIPLSYHHLIPRGVHAKVLKKGWHEEWMLNSVAWLCRACHSFVHRMASNEELAREYYTVERIMEREDVQDWAKWVGRVRWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ07</accession>
    <name>B0XQ07_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_008270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ07"/>
    <dbReference type="HOGENOM" id="CLU_129084_0_2_1"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ07"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="117" mass="13133" checksum="2507E1BFB001165D" modified="2008-04-08" version="1">MFPRVLLSSEPLSSGAGQWSRSLQSSPILPHRLLRPAALSLNLPGLFSGIWDSVLRAVPKKKTSHMKKRHRQMAGKALKDLKNLNTCSGCGRMKRAHVLCPHCVEEIKKQWKHTQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQH1</accession>
    <name>B0XQH1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_009940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009940"/>
    <dbReference type="HOGENOM" id="CLU_110381_1_0_1"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="PhylomeDB" id="B0XQH1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="203" mass="23153" checksum="7B6DBC8970E0B7A0" modified="2008-04-08" version="1">MPSFDDDPPEPIWPPVGGSSGGGSHQTKKTLVPQRTSQIDLAHLQSSLSTIPVRHDTKPPTMSTSKVKAGQLWGKSKEELSKQLEELKTELSQLRVQKIAAGASSKTQRIHDVRKSIARVLTVINANQRAQLRLFYKNKKYTPLDLRPRLTRALRRRLTKHEATLKTEKQRKKEIHFPQRKYAVKTNVVSGSEMELREGRYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR44</accession>
    <name>B0XR44_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PBSP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_012190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012190"/>
    <dbReference type="HOGENOM" id="CLU_062644_0_1_1"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="PhylomeDB" id="B0XR44"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="316" mass="35149" checksum="096A8DC520CD4006" modified="2008-04-08" version="1">MTSSMSPLPSAIPRTIPRPNDLQSSQRQTTSSRVSPKPEPELPRPKFRLHLNDLRHPATLSFISLVPDVASTLDTALKAIVRHLYTPPSLSPNESSNAPARKCPRPSFTPCIPPTRSVTVLVRDISGVAYTTGIELDDDHKEIHLSLSYVKTSAENNPDPAAEITGVLTHELVHCYQHTTPNGDESASVPRPPGGLIEGIADFVRLKAGLEPPHWKRPTSAKERPSKWDQGYQHTAYFLAWLEDVRVGKGAVGMLNDRLLRVGYVGEDSESENQDTQSFWRGLFGKGISELWEEYGEYLDRSRNSGNWEDEIINPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRF6</accession>
    <name>B0XRF6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane protein Pth11-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_002300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002300"/>
    <dbReference type="HOGENOM" id="CLU_028200_12_8_1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="PhylomeDB" id="B0XRF6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="174"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="361" mass="40565" checksum="D51E798EE804CEE8" modified="2008-04-08" version="1">MEDSSLGVDPTKTPVVPAPAGQQSNFDNPASHANDYYIIAGICTALMTFLVFVRLYIRFLVTRTPWWDDSHRCTTQLFQSAYTGVVMKEGSLGLGRHAWDVTLAKFAEFDKYARPLTAPAIYFTKLTLLLLYLRLFLLNRPVKFGIWGGIVFCTIYYTAAFFLNLFLRDLHALSKLAYSVGVFSVVSDVYIITLPLLAIVQLRLSRAKKWRVAAVFLTGLLSVVMSFLGCIFRFQVNVMDITYSLLPIYIVNTVEVDIGIICTCLPLLGALFKENTKESRQPTGFRSIHNHLPSSRSRFPRSVDRKHQNHNSDNIELIPQTSAAGVVPETYPVSPPSSSPNAIWRITTIEQKWGESSVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRH7</accession>
    <name>B0XRH7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_002510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002510"/>
    <dbReference type="HOGENOM" id="CLU_002458_0_0_1"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="PhylomeDB" id="B0XRH7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="629"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="40"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="215"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="430"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="835" mass="95209" checksum="B82C3A082906B46E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSB7</accession>
    <name>B0XSB7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_026620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSB7"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_3_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="PhylomeDB" id="B0XSB7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP54603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="324" mass="36248" checksum="4BCE6E82CC3888EF" modified="2008-04-08" version="1">MGITFGYMCRIWQLLSSSCSVLRLLPSCTSTVSSRLGPGSASHLRRGGICKVSFENFYPHIELYGYGGRIGAHNNTASLFSYAISNDGVLLAPALFAASIYMTLGRVIRAVRGERFSIISLNWLTKTFVLGDILSFVVQGSSIGLSVTGHATGATAVVLIGLFIQLISFGIFGLTAVMFYRRIMEAPTPQCHNADLPWKRTLEMLFGVSALIIVRSVYRVVEYSVGSNGYLLQHEWPMYVFDTIPMLTVMIIFYIWYPSRIQQPSSCEDQQTSRQHYSTQSSLSSQHFNLRSNVWYAPWQNTSDQTIMSILDLSVRIASLIRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSK8</accession>
    <name>B0XSK8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LSM1</name>
        <name evidence="15" type="ORF">AFUB_027550</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027550"/>
    <dbReference type="HOGENOM" id="CLU_076902_0_0_1"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="PhylomeDB" id="B0XSK8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="177" mass="19926" checksum="6BE0669FA6ADC2A9" modified="2008-04-08" version="1">MERLSLNDPPAGAQRGNAPQSFSQQNNMLGPSAPMTQGPPQLPPQMFTTAAQLLDLTDKKLVLVLRDGRKLIGVLRSWDQFANLVLQDTIERLYAGNLYADIPRGIFLVRGENVLLLGEIDLDKEDDIPPHLQKAPFQEVFELKKKEDSRRKITDKKSHNKLQSLGFEPEHSGEILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSX6</accession>
    <name>B0XSX6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_028140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
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</entry>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
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                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
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                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
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                <person name="Orvis J."/>
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                <person name="Sundaram J.P."/>
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</entry>
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                <person name="Amedeo P."/>
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                <person name="Silva J.C."/>
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                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
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        <property type="protein sequence ID" value="EDP54851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="B0XTE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029100"/>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
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    <dbReference type="PhylomeDB" id="B0XTE2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0005509">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
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        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
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        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF208">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758331" description="alpha-amylase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="35"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="52"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP54851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="471" mass="52407" checksum="F74C306F76110620" modified="2008-04-08" version="1">MRQSLYHGAIWSALASLASADAPSSQQWAERAIYQVMTDRFARPAGSSDAPCDPERYCGGSWTGIIDKLDYIQDLGFTAIQISPVVENIPDNTKYGEAYHGYWPKNLYALNEHFGTADELRRLVSEVHRRDMYLIVDVMINDMAQAVNGSMKDDPSLKIDYSQLFPFDDEKYYHPFCAITDWTDPKIYKNCWFAVETVALPVLNTGDASVATMIGDWIKQFVGNYSIDGLRIDAALHMDDDYVEGFSKAAGLFTIGEVSNGDTSLVCKYENLVSSVLNYPLYYALIQAFTAGNMLGLAESIRAVQKDCKDFTLLETFVENHDLPRFASLTNDTTLAKNAMAFNILSDGIPQVYQGQEQHMSGNYTPFNRGALWTTNYDTTSPLFKLTATLNKLHNHAISIDNHYVTNHSIELHSDNSTYATRKGPEGVQAVSVFSNQGTNGGKYQLALKDAYAPGTEVMEVWAAPSSLLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUF1</accession>
    <name>B0XUF1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_020510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020510"/>
    <dbReference type="HOGENOM" id="CLU_002718_1_0_1"/>
    <dbReference type="OrthoDB" id="3925024at2759"/>
    <dbReference type="PhylomeDB" id="B0XUF1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7165"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
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        </location>
    </feature>
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            <end position="937"/>
        </location>
    </feature>
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        <location>
            <begin position="647"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="974" mass="107978" checksum="552A5F0D52BCB506" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUJ5</accession>
    <name>B0XUJ5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_031110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031110"/>
    <dbReference type="HOGENOM" id="CLU_085773_0_0_1"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="PhylomeDB" id="B0XUJ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257:SF1">
        <property type="entry name" value="DUF1330 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760633" description="EthD domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30703" checksum="D107149E1D395235" modified="2008-04-08" version="1">MPGLTLHLLALAPSTTAESFLRQLRQSSAIKIILASRPQHIVIPPTLIDSNLLTTTKWDLLVLLQPSSRTQEAARESLPPNLQPLVQQEYRLAVGVPSKLLSNYDDRDRSLKRAASSIPLTGSLANAHQKPSSKNLELSPDLLAYMDTLTRTHDGPVTMLNLLHFHHPNGKKSYYQYGQAFIPVAGKRGGNAKLVGNVIRPASTAQVDSRGSLDRPETDWWNEISLVHYPSIRHFCDMLAGEDYQAINEKYRLSALRDTFLLCTTEFDVESSPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUU2</accession>
    <name>B0XUU2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_031430</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031430"/>
    <dbReference type="HOGENOM" id="CLU_015166_2_2_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="B0XUU2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000206">
        <property type="entry name" value="Calcium dependent mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="268"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="389"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="492"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP55082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="585" mass="64414" checksum="709EABB09D386463" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUU8</accession>
    <name>B0XUU8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-C domain protein HetC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_031500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031500"/>
    <dbReference type="HOGENOM" id="CLU_010063_0_0_1"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="PhylomeDB" id="B0XUU8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757913" evidence="2">
        <location>
            <begin position="29"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="804" mass="88742" checksum="056707A8BF1B5305" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV04</accession>
    <name>B0XV04_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_032060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032060"/>
    <dbReference type="HOGENOM" id="CLU_055310_1_0_1"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="159"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="251" mass="27724" checksum="24248A7DBB32DBEA" modified="2008-04-08" version="1">MSTTATTTVTATTLVGMLPTMTSATSNILGKSCPTCGQDGYMSQDQLAESARKRVKELEGQVELLNAHATQMAAQLAEYEKEVRRLRSQTNTHTPRTGSASSTLSTPSNESEHSRSSPPQAQQQSRLSTLTSLLPYRRPSTASPTQTMAQPAQPVPSPDQVTTELQTALEREQSLRKAAESQLTQASSELEELTAQLFSQANEMVAQERKARARLEERVAVLERRDVEKRKRLDRLEKAMERVERLRGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV38</accession>
    <name>B0XV38_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_021540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021540"/>
    <dbReference type="HOGENOM" id="CLU_021599_3_0_1"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="PhylomeDB" id="B0XV38"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="510" mass="55632" checksum="13DA634EFEFDBF0A" modified="2008-04-08" version="1">MVGVPHSTGCSLCRERRIKCDEAVPQCSQCRKYGRPCPGYRRTFRFQDEGPALQRRHQSRSQSRRPAVVRNNAIAMMRQTRSEDPCSSSAAAAAAAAQSQTHLHQMQLQMQMQLQQPHLFASFLHSAFPTLYTSNIFRAHNRPDFLAHVASSYASGAAPYLAATLACLTSIYTAQFSPDPAQHTRRSRQLYAHALTHVVAALHSPAALSAPLLATIMMLAVYEMYARTSPDAFVVHVDGVRRIMLARGPGLHFPDDKDKDTDTDNNNNNNHPPASAIADAADADADADADASGEGPGFARGCYIAFRGFLVATALYEGRACFLDEEDWLRFAGRIRAEDVRKAGRDARVVDVCERIWMEVVRCPRYFAEALPEGRPGTVPEGVDAGLDEGLDEGLAARVRATRSRLVRLVDELRVVLGGSGRGREETGPGLLLQGAEDMVAALESLLVWLRGGSGRRRRRGGGGGFRVVSDFQRGVSSASSEALPVTWLDRVASSMGVIGLKVIWEDSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVJ8</accession>
    <name>B0XVJ8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_022500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022500"/>
    <dbReference type="HOGENOM" id="CLU_093932_1_1_1"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="PhylomeDB" id="B0XVJ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP54198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="121" mass="13167" checksum="649F40850885F49E" modified="2008-04-08" version="1">MSAIGSLIFCTDCGNLLPESTGDPTKILVCDVCGARNKDTVPNTIISESKPNAFPSTLRAKRSAVQTLTAEDKRTEALTQHTCARCGRKEMYFTTVQLRSADEGSTVFYTCVCGYKETTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVS2</accession>
    <name>B0XVS2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_022570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022570"/>
    <dbReference type="HOGENOM" id="CLU_035888_1_0_1"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="PhylomeDB" id="B0XVS2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="430" mass="49622" checksum="FA55EDDD84596D75" modified="2008-04-08" version="1">MSALVEAPSQFKQPSRKGKKAWRKNVDVTEVQEGLRLLKDEEIKGGVLAEKPSEELFVIDKKGSAEIRNAYFKQHKPLKADEILAQRSAIPAVDTRKRLNSKVTDGVIEPKSKRHKSDWVTRKEWLRLKQVAKEANPTQTAEESELYDPWADSEDPTPVEDPQFDYLEKPKPKVAPPTIKQPPISLAANGKPIPSVRKPDAGISYNPSFEDWDRLLQEKGHEAVEAEKKRLEEERKEQERQRLIAEAQNDDGEVKSDDESAWEGFESEYEKPEWLNKKRPARKTKAERNRIKRRKEAERKARWEAKMKQKEEQLEQAKAIAEQVQQRQLERSRESGDDSSEEGDDAALRRKPLGKARVPEKPLEVVLPDELQDSLRLLKPEGNLLDDRFRTLIVQGKLESRKPVTQAKKAKRKLTEKWTYKDFKIPGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWJ0</accession>
    <name>B0XWJ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Extracellular serine-threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_036090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036090"/>
    <dbReference type="HOGENOM" id="CLU_013457_0_0_1"/>
    <dbReference type="OrthoDB" id="5431405at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757970" evidence="10">
        <location>
            <begin position="18"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="496"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="653"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="297"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP52443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="719" mass="71765" checksum="0614A8988C7AE2B6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWM0</accession>
    <name>B0XWM0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_046580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046580"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="PhylomeDB" id="B0XWM0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000295">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="517" mass="56647" checksum="456613B92DDBBCEE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWS4</accession>
    <name>B0XWS4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_047140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047140"/>
    <dbReference type="HOGENOM" id="CLU_126668_0_0_1"/>
    <dbReference type="OrthoDB" id="4417158at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="146" mass="16071" checksum="4F3B4E4F327BD049" modified="2008-04-08" version="1">MFSFRPVNLPPHVLLTSTTVIGLGLYISLFRTSPLKPLTGRDVLVPAPSTSRIADTNALLGVVACALQLPYFLSSYMPIEKNQWLHVTVPIRLFVTTALGVNVLLRGRRMSEEGFWEFLALGVTDFVGAVMLGWELGRFDGMVSGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWT3</accession>
    <name>SEC11_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Signal peptidase complex catalytic subunit sec11</fullName>
            <ecNumber evidence="1">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Signal peptidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sec11</name>
        <name type="ORF">AFUB_036330</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="1"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWT3"/>
    <dbReference type="SMR" id="B0XWT3"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="EnsemblFungi" id="EDP52467">
        <property type="protein sequence ID" value="EDP52467"/>
        <property type="gene ID" value="AFUB_036330"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036330"/>
    <dbReference type="HOGENOM" id="CLU_089996_0_0_1"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="PhylomeDB" id="B0XWT3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000412343" description="Signal peptidase complex catalytic subunit sec11">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal short (CTS) helix" evidence="2">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P15367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P67812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="192" mass="21457" checksum="9063E519381F4324" modified="2008-04-08" version="1">MLSFLSSNLSSTRQSMAQVLNFALVLSTAFMLWKGLSVFTASSSPIVVVLSGSMEPAFQRGDLLFLWNRSPRAELGEIVVYNVRGKDIPIVHRVVRTFPQIEGKAKKVKEVNEASSVPPNMLLTKGDNNIADDTELYAKNQDFLHREEDIVGSVRGYMPMVGYVTIMLSEHPWLKTVLLGIMGLMVILQREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWU2</accession>
    <name>B0XWU2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="17">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_036420</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 17">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16 17">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="17"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036420"/>
    <dbReference type="HOGENOM" id="CLU_014329_1_0_1"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="PhylomeDB" id="B0XWU2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000006">
        <property type="entry name" value="Crossover junction endonuclease mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="19">
        <location>
            <begin position="299"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP52476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="596" mass="67303" checksum="EF4A5755EC6B06BF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWW7</accession>
    <name>B0XWW7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_036670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036670"/>
    <dbReference type="HOGENOM" id="CLU_047019_1_1_1"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="PhylomeDB" id="B0XWW7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="396" mass="46483" checksum="39C80A75BD33EAE7" modified="2008-04-08" version="1">MIRDQVLSEYSIHHASVSLLNLFLCDSIAHTNALSSHLLGKKSWNVYNPENIARVRRDEAEAKAREEEEERRMQEIDAERRIQILRGEQHSTPPPPPSALSDTRRDRTHGEDAGRYRKRRRLAGENDTDRDIRLAREDAQLMMAKKEELAVSKKTSDAPLLDSKGHINLFPSEAAQQPVEKNKEAEKEAADRNRSYEDQYTMRFSNAAGYRQSAGQMPWYSSSSRDALAPDAMPEKDVWGNEDPMRQEREKARLDANDPLMAIKRGVRQLKSVELKRKKWNQERKRELDSLKEAERHRSRHRRRRSRSRSKASDSGDSLENFSLDAPDKHQDRKHRSSHRHRSHRRERSRSRSRDHFCEQSRKRHRHSHSHSHSHRHRDHHDRGGVCEVQSPRRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX27</accession>
    <name>B0XX27_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_047500</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047500"/>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="PhylomeDB" id="B0XX27"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF220">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758435" description="alpha-amylase" evidence="17">
        <location>
            <begin position="26"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="38"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="55"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="459"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP53568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="549" mass="60956" checksum="2446BCE52B09B35E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXD8</accession>
    <name>B0XXD8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_047980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047980"/>
    <dbReference type="HOGENOM" id="CLU_033465_0_0_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="PhylomeDB" id="B0XXD8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF34">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="288" mass="32352" checksum="D52232E5FE9DA5CA" modified="2008-04-08" version="1">MHPLCAVLFTVGYAMRAYGADGHYIYNPDSSQNLLVYILSQVFIYICPPLLELANYHVLGRLFYYVPNLAPLPPGKVLAIFGALMALVEALNALGVALNANPTGSQQGLGKALILVSLALQLCVVLAFVLTAASFQWRCAKANIRRRSLPTLLITLDISMGLILVRCIYRLIEHVDNTSVDLGDPEGLRSLSPLLRYEWFFYVFEASLMLLNSFLWNVFNPGRYLPRYPTVYLAADGTTEIEEEEVRNDQHFLVKSAYAAVNALTFGLFRLFVRQKDEENHPLTERTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXE4</accession>
    <name>B0XXE4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl xylan esterase (Axe1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_048040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXE4"/>
    <dbReference type="SMR" id="B0XXE4"/>
    <dbReference type="ESTHER" id="aspfu-q4wg03">
        <property type="family name" value="Acetylxylan_esterase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048040"/>
    <dbReference type="HOGENOM" id="CLU_040058_4_1_1"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="PhylomeDB" id="B0XXE4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758450" evidence="6">
        <location>
            <begin position="17"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="7">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="29275" checksum="A1085D2625FC631F" modified="2008-04-08" version="1">MLFTAVTLALLGQALAGPVELEERQSSCPNIHVFGARETTAPTGYGSSSTAVNLILNAYPGSTSEAINYPACGGQSSCGGVSYANSVVAGINAVVSAVNSFNQRCPNTQLVLVGYSQGGQIMDNALCGGGDPNQGYTNTAVPLSSSAVNMIKAAIFMGDPRYVAGLPYNVGTCKAGGFDPRPPGFSCPSASKIQSYCDAADPYCCNGNDANTHQGYGTEYGQAALTFVKSKLSSSGSGGGSGGGSGGSGGSGGSGGTVAHYGQCGGQGWTGATSCQSPYTCTVISQWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXQ2</accession>
    <name>B0XXQ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BZIP transcription factor (MeaB), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_038200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038200"/>
    <dbReference type="HOGENOM" id="CLU_035241_1_0_1"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="PhylomeDB" id="B0XXQ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="404" mass="43791" checksum="3F307A2FD4E50F3C" modified="2008-04-08" version="1">MVSMVETSNSNHNDTATDSVVPKSEPLPEGSTSSSVSTPEAEGEVPTQDVAQTQKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIRQLETTIKRNEETLQTLQQNHRTAADECLMLRYKNSLLERILLEKGIDVQAELRLKAGAPPGAPIKPNIMAAKPPSTLDRAAVNRTAAQRLPAGIAPKGEPFAMSRDGTYGIPSPQFQATPSSHVSSPSHTKSPGFAFQGAMSPNGMDAQQAQHARSQLNLHSRNMSQTSPPISIGQPESTDPKSAVSGGPGPRVSRVPSAAYYPSPFQKHYDQLEQEYDAQADMIDEEHESVDAPPYVSGFNAATTSVPPGSHSLGPQLANFNPHAGEGSNGAYGATNHLLGNYEPMLDADPFGLSASMHFQTPFSYEQNHSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXZ5</accession>
    <name>B0XXZ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_039100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039100"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_37_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PhylomeDB" id="B0XXZ5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004711">
        <property type="term" value="F:ribosomal protein S6 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="230"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="492"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="593" mass="65144" checksum="7F2F25AF8E1AA707" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY62</accession>
    <name>B0XY62_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_039770</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY62"/>
    <dbReference type="SMR" id="B0XY62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039770"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_1"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="PhylomeDB" id="B0XY62"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990621">
        <property type="term" value="C:ESCRT IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="165"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP52808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="435" mass="48083" checksum="0C85ABFA58E91960" modified="2008-04-08" version="1">MTNNTDFLGRAIDAVKKAIELDNGGEYEKAYQGYYSALELFMLALKWEKNPRSKEMIRAKTAEYMDRAEKLKNHLAQSEDKKKPSAIGANGKVAQGSGKGGKEDDDNEDADAKKLRSALAGAILSDKPNVKWEDVAGLESAKEALKEAVILPIKFPHLFTGKRQPWKGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFNMARENKPAIIFIDEVDALCGPRGEGESEASRRIKTELLVQMDGVGKDSRGVLILGATNIPWQLDAAIRRRFQRRVHISLPDLNARMKMFMLAVGQTPCQMTQADYRTLAEMSEGYSGSDISIAVQDALMQPIRKIQTATHYKKVMVDGAEKLTPCSPGDSGAIEMSWVDIEADQLLEPPLMLKDFIKAVRNSRPTVSQEDLQRNAEWTKEFGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYT8</accession>
    <name>B0XYT8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_042050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042050"/>
    <dbReference type="HOGENOM" id="CLU_2014737_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="123" mass="13524" checksum="A163F1C1455CC9C1" modified="2008-04-08" version="1">MVNNKSSGEIQMGNRMIMIAAHSSRPLARAVIIKVMRRSTHPAITFGHDLRIEVEIKSIHRPIVMIANDNCRGNGAVRLALLIWSGALEPRWLRRSANAFPGCQVNACVAQTVQAVEVIKSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZK0</accession>
    <name>B0XZK0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_034140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034140"/>
    <dbReference type="HOGENOM" id="CLU_093227_0_0_1"/>
    <dbReference type="OrthoDB" id="4749694at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="192" mass="20640" checksum="5F30439418C96322" modified="2008-04-08" version="1">MASLTGVTQRSASGNKDDGSPVGDLYSKIATGGFGLWISAVIVLGLSAGIISKTPPSALRSAASYNLAVAALEFFLALSSITKPVSPTKARSPARFIIILAFTTMMWGAAFPLMFVTRSNRETYKVINLDKRVLVSFGTGVVGILQNITIACACLGVSAFIFVLYQWYCLCRLFLGKFTPEEIRQAYGRHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZW2</accession>
    <name>B0XZW2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LipA and NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_034580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034580"/>
    <dbReference type="HOGENOM" id="CLU_010646_0_0_1"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="PhylomeDB" id="B0XZW2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="643" mass="70884" checksum="C087BDDD6676DDCB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y095</accession>
    <name>B0Y095_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">AFUB_035220</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y095"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035220"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="PhylomeDB" id="B0Y095"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="346"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EDP52359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="382" mass="43078" checksum="0F89DC2D17EB0ED0" modified="2008-04-08" version="1">MAGKANMRSRSESNSPLYFFPIVADQIRFKPDKEGEIIQYTGLSQSAIREMALCSELDHPNVVQLAEIILEDKCIFMVFEYTEHDLLQIIHHHTQPQRHAIPAPMIKSILFQLLNGLLYLHTNWVLHRDLKPANILVTSSGAVRIGDLGLARLFYKPLNSLYSGDKVVVTIWYRAPELLMGSRHYTPAVDLWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMMKIIDIMGLPRKETWPGLVSMPEFSQLQSLAMSRGYINRQCNLEGWYQSCLKNNGYSPGSAAGTPGAEGFDLLSRLLEYDPTKRISAREALEHPYFTTGTPVTANCFAGYEGKYPHRRVTQDDNDIRSGSLPGTKRSGLPDDSLMGRAAKRLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0B6</accession>
    <name>B0Y0B6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_035430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0B6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035430"/>
    <dbReference type="HOGENOM" id="CLU_041682_1_0_1"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0B6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="387" mass="43004" checksum="733BE85663B223B0" modified="2008-04-08" version="1">MSDPLGLISSKCFHRRVILDTAYGPLTISFADIGGTTGPALLFLPGMFASRYLSIPMHVIAERAGVRLLVVDRPGMGASTNVPLAQRIAIWVDMLPRLLAHLGIPRVNLVSHSAGTIYLLNTWAQCRELVGPVVAFLGNFHPYPSLFFCLFLGWKTRQRNKTQKRRRITQYSVIAPWVDLAHSRVTVMQMAQYVPTKAFAMWHLIPHFVVTQASPVLASSGAVVRRLSSQSSEAADRSFLDANWRRVERDYGVPHAEQAELARLAFRFMYEEDTVGANSEALQCLRKGDGSSWGACSDYAHCVQALAAGERSTGGRVSVRTYFAAKDALVGSRGQKYFEECWRAPGLEGIDYISTTIDGTDHDTLVQSVEVWEEIFSSVPQMTLYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0C6</accession>
    <name>B0Y0C6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_035530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035530"/>
    <dbReference type="HOGENOM" id="CLU_081053_0_0_1"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="218" mass="24728" checksum="1C37A8C39A873633" modified="2008-04-08" version="1">MHHNDHSNGMPMSMVFDTSTEITLFFQGWTTTTAASYSLTLLFLFALAVFNRFLGVLKFQLDVKHTQPTEGRVPKLQQPRARRRHAIPKARLSPQPRYMQVAETDTEDEAPFSSAQFLESDAEHTRHEFPSDLIQEPQGPLGTRRWWNVYRRWSWRRDGTGSLLEGLRALVGYALMLAVMTFNVGVLCAVVGGIVVGELLLGRYAQPSLGWQDDACHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0G4</accession>
    <name>B0Y0G4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_046100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046100"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0G4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000805">
        <property type="entry name" value="3-beta hydroxysteroid dehydrogenase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="341" mass="37085" checksum="2BF7315EAC1B74D2" modified="2008-04-08" version="1">MSMKLPFRVLVTGATGFIGAHVVDSLLDRGITVRGATRSLSKGEQMRAARPDHASRLEFVQIEDFSKLGGFDHVMEGVDAVIHVASPFTYNTTNNEQELILPAINGVKSILAASAKPGSTVKRVVLTSSFASVIDISKNPGPDFTYTGAHWNPITYEESVDPATSAVVAYRGSKKFAELEAWNFMDREGPPFDLVTLCPPMVFGPIVHPVASIAQLNESNAVLWSVAAGADPLPAARVSAWIDVRDLAEAHVQALLTPEAGGKRYVPASGEPFCYEYAADIIKEKFLWARETVTTNYEAGKRPGPTYKLDGATVTRELGVKYRSFEQTVEELVRQVKETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0H7</accession>
    <name>B0Y0H7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ion channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_046240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0H7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046240"/>
    <dbReference type="HOGENOM" id="CLU_095787_2_0_1"/>
    <dbReference type="OrthoDB" id="10010920at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0H7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.120:FF:000004">
        <property type="entry name" value="Ion channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="entry name" value="Large-conductance mechanosensitive channel, MscL, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266:SF2">
        <property type="entry name" value="LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="MECHANOSENSITIVE CHANNEL MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="Gated mechanosensitive channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="215" mass="24206" checksum="C530F792DBFB00AA" modified="2008-04-08" version="1">MPRLDDSTEALLRAGQSAQSTVKRAWDGFVNFAVRDNVLEVALGLIIAQAFTKVVTSFVSDIILPIVALLPFLHRNMDEKFAVLRRGPHYVEEKGYNTLEQARNDGALVLAYGAFLETVISFVGVSLTLYAIGHLYTWISHEQVIKQTVQCKYCRKYISEKALRCVNCTSWQDGREDAPQRRNEIATSANYRNGYEIICLHSTLWQIPPPTGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0T4</accession>
    <name>B0Y0T4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_058460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058460"/>
    <dbReference type="HOGENOM" id="CLU_1170918_0_0_1"/>
    <dbReference type="OrthoDB" id="4492273at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="250" mass="28161" checksum="69DE73FF391896BD" modified="2008-04-08" version="1">MMDEIDFELCLDVDQVATAFYREKRKRYSIHSNITNSINNTTPRIRTHNELGDSTADESMITIVPPAKRARISQSDVPFQTESTNTSYQSTGPLLDSSQFLNHHTDFFNFKRNQGGPVNANDVLPAVPRRAMSEEMDIDMMYMGSETEAEAETGSPPGRFHDQCRIHSFGTWSNPSLRGGLGSFSSRVNNSPSMFAIYEDAMDMEIEGVFCGEEWYYSPDEDKENVENGNEQGSILQEMDSNSVAVHRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0U2</accession>
    <name>B0Y0U2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_058540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0U2"/>
    <dbReference type="HOGENOM" id="CLU_009650_2_2_1"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0U2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="483" mass="56201" checksum="2516A1A44F71D0A3" modified="2008-04-08" version="1">MTLIPNTIVQNGAGFGKEGSVRAEVPEIEISIVQTPKTWYFPFPMYGSYDALGLDGFSCMDRYTRFGAYGYSGTDSQLQGARPLPPVDWKKVNWRTLQEDCFERNSDRYESAKQSLSMHSLPLTSPRSAVILRAWHDMPWTENMKHYVRSLVMELSLHTGSEYQVFILTHVKDNNIPIYAVNGDDNAQRLKEKYMPKEFHDMTILFNDHTLESWYPAIEEHRPQYQHLQPLQIFSQVFSDFDYYWQLEMDSRISGHSYHFFEKAADFARNQPRKYLWERNAYFYIPGAHGPRPPVAHPRDDHYEWGVGEEADLMLFLPIFDPIDTKWTYPTMIWNLSERDPRRAAPITMGRYSKTLMDAIHSAQVGQGIGLASEMTAPSFALWHGLKAVQVPHPIYSDGKWTPKELNRIVNKGSPEKMNGGPDSIWNWNHEYDHILFRTSYMFTTQTAEDLYRRWLGYVVDPHQYTDGSYTLRDVTGLTTAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y128</accession>
    <name>B0Y128_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_059390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y128"/>
    <dbReference type="HOGENOM" id="CLU_000288_82_1_1"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="PhylomeDB" id="B0Y128"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="410"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="649"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP51919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="825" mass="90451" checksum="1A31C47701F9C50B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1P2</accession>
    <name>B0Y1P2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_050000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1P2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050000"/>
    <dbReference type="HOGENOM" id="CLU_023417_1_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1P2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="480" mass="53975" checksum="62796034AB9DD25E" modified="2008-04-08" version="1">MPAMEDCITRTQTSYRRPRRRPAHLRTKTGCLTCRSRKKKCDESGSPCQNCVQRKIECVWPGRRAGLLAHSGGSSVSAESASETECQVVRTQTPSMITLSNGPASYSSVLAPANSQLFHFLQTIFLPQLIHPVTTGAVNELVTRESLRWAFQSPFCMHALLACAAAEIPVNNPQYRRMAELHYIKAVADLRQSLVPTADSSQWTVVLWTVLMLCIYERSKPHHSQGVDVHLAGAAQLIQLYFQRKTPDASIIETGAWARVFLESFMFHVATSIPFQLTSTRSTTIDSAFALAESILEVVCRPQISVDATSPVLGVPPKLFQYVYTIARMYERYPDSVDLRQCKELEQDLRRWDTLMAVTATPELLTGPRLYVLCSRILLNRLLNLDNRTDDPVVSELVSQAMVLVTQLQPALDYFAEYYSWPFLVLGTCAEKQSHRQILLSQIQGFWQATNNGTMKRLENMLTAHWTGGESTSKANLWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2R7</accession>
    <name>B0Y2R7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ulp1 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_051710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2R7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051710"/>
    <dbReference type="HOGENOM" id="CLU_431444_0_0_1"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2R7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="60"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="634" mass="71721" checksum="9C5AB455CA4DF181" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2U4</accession>
    <name>B0Y2U4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_052000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2U4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052000"/>
    <dbReference type="HOGENOM" id="CLU_1038192_0_0_1"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2U4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="267" mass="28856" checksum="FFBFC946ADE6DAC5" modified="2008-04-08" version="1">MPTIDASFNVSFPKHNNTLVLSTRYIVDGCAECKQDKPGQAPSMSPKSVGDDKESSNQGPALTSRWSQKWHCSSDFNFASFSSIAALQFVLSASPGDTALSRLNDRLPPFLRSYTTPLLGAPGTHITSFLILHEITAIVPLLGLVASFHYGDWLPDFTSKSGFDEGVQRFGRWLRKKGWVEDADVDIVNSDGSASGNDSTTGSPGQSQLRPEDRKGVRLVLEFATAYAITKALLPVRIVVSAWATPWFARSVLAPVGRGVGALLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y304</accession>
    <name>B0Y304_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aspartyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_052490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y304"/>
    <dbReference type="MEROPS" id="M18.001"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052490"/>
    <dbReference type="HOGENOM" id="CLU_019532_3_0_1"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="PhylomeDB" id="B0Y304"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="516" mass="56024" checksum="8B2CEF4D4B70B6E0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3J8</accession>
    <name>B0Y3J8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_054450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3J8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054450"/>
    <dbReference type="HOGENOM" id="CLU_040458_0_0_1"/>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="208" mass="23749" checksum="FEBD41BA9ECBDFC1" modified="2008-04-08" version="1">MTSTAGKPDISLPTNLQNMYHMFRTVDEGQAELWRSDTVRLANSIVPLNEEVNWDGHTTILGSAQLVLGERSKQARRSAVERLVSNILDGPMRLMLRKLSSPKEVDQRSKIMVDVYCRMAELATRCWAERQRWDIRGLDKVDRFHWVSETLDLHFLQMATKDDPKFDGKAVLVVVQPLLYLCGGLDLQFNYDRMIAKGLAIVEDPDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y479</accession>
    <name>B0Y479_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_056810</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y479"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056810"/>
    <dbReference type="HOGENOM" id="CLU_005034_0_1_1"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="PhylomeDB" id="B0Y479"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001282">
        <property type="entry name" value="ER membrane protein complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001817">
        <property type="entry name" value="ER membrane protein complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760426" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="22"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="21"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="727"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP51670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="952" mass="103548" checksum="65F7F226E76EEDB9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4E2</accession>
    <name>B0Y4E2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_057490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4E2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057490"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4E2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF17">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="299" mass="33256" checksum="F2520184513C5985" modified="2008-04-08" version="1">MDFTFHNGTNGSSPWVEFYPYTPSATAGYTFMSIFGMATVAHIILMFPYRAAYFIPLVLGGICETFGYYGRAWSHKEGRTAIGPWALQEMLILCAPPFVAASIYMVLGRIICAFDAEHHSSIRTKWLTTIFVLNDVVCFLTQLAGAGVQITGDPHVMAIGKKAVLAGLIFALVVFGVFVWVAAAFHRRLDAEPTAVVRECPRLRWKKYMWVIYVSCGMLMVRNLVRTVQFGSRKGSALNTEEAFIYVFDAALMAGSILVLIVWHPGRLVRRAQKATKASQMCVQMEDAPDIPLTGYREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y533</accession>
    <name>B0Y533_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spherulin 4-like cell surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_071230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y533"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071230"/>
    <dbReference type="HOGENOM" id="CLU_060605_0_0_1"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="PhylomeDB" id="B0Y533"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="288" mass="31990" checksum="77ABF78600D273FD" modified="2008-04-08" version="1">MASSKLQGRRNLWIGIGVAIAIVVIIVIVVPLAVLLPRKHHGKKATILFPLYIWPETDSTWDPLYEEVTNYPNLNFTIIINPSSGPGNGSQPSPQYAHQIQRLNAYPNVRTVGYVRTGYASRNLTTVLQEVGIYSGWAAVSPSLAMHGIFFDEVPSEYTTSAAEYLATINAAAKNASGLRTDRTVIHNPGAIPDSRYRNIDGTDVTVVFEQSYQEYQIKHASLMALPANRTAYSYMVHSVPSMNNGTLRSLVQDLSERAEYLFLTTLSQNFYESFDPQLPTFCAVMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y587</accession>
    <name>B0Y587_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_071760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y587"/>
    <dbReference type="SMR" id="B0Y587"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071760"/>
    <dbReference type="HOGENOM" id="CLU_065416_0_0_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B0Y587"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000680">
        <property type="entry name" value="Ubiquinone/menaquinone biosynthesis methyltransferase ubiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="282" mass="31896" checksum="2C0CACAFDAACB345" modified="2008-04-08" version="1">MLEKVFHEKSFADQYTYGAKISELYAETLITESGIAKSHQRPLIILDNACGTGSISSTLQRTLDERNKRSLKLTCGDLSEGMVDYTKQRMQAEGWNNAEAKIVNAQDTGLPSDHYTHVYTAFAFNMFPDYKAALRECLRILQPGGTLATSTWKTANWCTIMKPVIATMPGQLSYPTMDEINTMLNKGWDRESDVRAEFEQAGFDHVNITTVEKQCLLPVQEFGEACKILLPYILSKFWTQEQRDQYEADVPSYLMRYLEREYGKDGLAPMKGVAIIASGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5P8</accession>
    <name>B0Y5P8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA thioester hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_064150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5P8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064150"/>
    <dbReference type="HOGENOM" id="CLU_032862_1_0_1"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5P8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="46"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="243"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="409" mass="45732" checksum="99781DD75EF47366" modified="2008-04-08" version="1">MPMRVKTPWIEALTKSREDAQSGQTPRTQGKPDLTPKRMSDSYYSAILPLSQDKWLLDSYLNASGHIRLGSLLMDLDALAGIIAYKHAGDSVATVTAAVDRITIEHPLMEICDLELSGQVTYATGRSSMEVSLQVTRVPAEGEPVKPEDVLITCAFTMVSLDPATKKPVPIAPLLVENAEERLLFHKGEENYQAKKALRTRSLLEKAPDAEESNLIHNMWTKEMAYLNPESPAQRPDNMVFMSDTVLKSAMIMQPQDRNRHNFMIFGGFLLKQTFELAFCCAASFSHARPNFISLDPSTFENPVPVGSVLYLRATVAHTEPLQRDGTTYTKVQVRVDSKVRDVEHGSKKSTGQFNYTFLVEKDIKVMPRTYGEFMLWTDARRRAQNAAAMVTGSKEPSTLRNIKDSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5V9</accession>
    <name>B0Y5V9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_064750</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5V9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064750"/>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5V9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="219"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="423"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="45"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP50144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="674" mass="72061" checksum="538642B6D5B3264C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5W3</accession>
    <name>B0Y5W3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_064800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064800"/>
    <dbReference type="HOGENOM" id="CLU_002136_0_0_1"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5W3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000009">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="555"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="704"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="852"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1147"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1293"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1442"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1636"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1636"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1693" mass="192938" checksum="F2A58CB3D8CBAF69" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y653</accession>
    <name>B0Y653_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium homeostasis protein Regucalcin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_065700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y653"/>
    <dbReference type="SMR" id="B0Y653"/>
    <dbReference type="HOGENOM" id="CLU_036110_3_2_1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="PhylomeDB" id="B0Y653"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000093">
        <property type="entry name" value="Calcium homeostasis protein Regucalcin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="281" mass="31362" checksum="A3E31B3AA666D889" modified="2008-04-08" version="1">MRPETSFVLSTSGTRSCICFQITSMAHSLSETCSVTANIANGGDDHKDLIVVAAKHGYALADRNTGQLSYIRKVWDEQEDPEKARRMRFNDGAVDSHGRFWAGSMNDPKVQKPTNEGVLFRLDPDLQLHRMVEGVSIPNGIGWNLRDDTMYFTDSPTAKIFAFDFDASTGTISNRRVHYDVGEPMEPDGFAIDEEGCIWSAIYGGGKIIRISPEGKLIGEISFPTRNITCPTFVGTELFVTTAKDDVNDEQFPESVRYGGRVYRIDVGVRGKPKNEFRFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6B0</accession>
    <name>B0Y6B0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_066280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6B0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066280"/>
    <dbReference type="HOGENOM" id="CLU_029124_0_0_1"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6B0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053105">
        <property type="entry name" value="Class_V-like_SAM-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="236"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="367" mass="41638" checksum="BAA1612D34968B79" modified="2008-04-08" version="1">MKYYNQSQSSRALEMIVQAYWIECYEARIAVIRLENPHLSSTEARVTALKEACAVLSWKEKDLRNRMAIWRGYKEIKDAGGWPALIFASSGVYRFCKYRTGFSEGFSTRLRHIRSSLEVAADTLHPEWRDLLHVIGQGDTRRQYHGHPHEWVTVTGAPALPLHATYAHLNLPNGFVYRFIDECVLDTTVFGEEDPRRVPDLDPDICQVCKSKQADDVEQNQCSCFPALFGGVKGPAPVQIFSTASGKNNGVVARVNFDRGAAIGEFVGLITNGISGVDVMVGGTKSRTYQIYQGEMGNFTRFINHSCRPNSQFQRFYWRGQERIIVVSRGVVAGREITVDYSDHYWKQLNKVCLCGELCCRFRESNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6U1</accession>
    <name>B0Y6U1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GET complex, subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_068130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6U1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068130"/>
    <dbReference type="HOGENOM" id="CLU_1019410_0_0_1"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30847" checksum="3BF8D989741C6609" modified="2008-04-08" version="1">MSSTEESPAQRAARLRRERREAKIREGGAARLDKITSLSGRTPQSAREESFSASSLSHSPSPQPPAPVSVAETGAPPQTQPASVRPTTSVEDQTPEDLQAQQEYIRALLRQNAPPVAQEAPDEDPTMKLLNSLMAGGMPGLDQGAGGPGVSQAELASALGLPPFVSSMLAAATRPKTDEEKREIWMWKVLHVLFSVVIGVYFLVAISASVATYGSQPPPPATARNPFVLFTTGEMVLSGARIMLRSRGGGLAGPGLWIQLFRDVIQDGSIVLFLLGMSAWWHQDWLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6U5</accession>
    <name>B0Y6U5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase iota, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_068170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6U5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068170"/>
    <dbReference type="HOGENOM" id="CLU_022440_0_0_1"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6U5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000067">
        <property type="entry name" value="DNA polymerase iota, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000019">
        <property type="entry name" value="Putative DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="596" mass="66449" checksum="27EB19BCDE4167E4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7B2</accession>
    <name>B0Y7B2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_073200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7B2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073200"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="OrthoDB" id="5331848at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7B2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="39"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="368" mass="41458" checksum="021D1F462A595235" modified="2008-04-08" version="1">MVETGQGGPPPRGGDRDRGALLLGVLWAQAGIATVIIFLRLYARFMIHTTGWDDWLMFLTLAIFIGSIIIVTLQDSVGGYRHLYYLDKDAAVRALELNFILRGVHIIGYATGKASIGAFILRLIGRQNMWQKWVVWVLIIFTTLVNVLNCIFNFVQCSPVQGNWDPRVSAKCWEKRAQLKFAYFMCSENIAADAVLAIIPATFLFNMNLSLKKRINMTILLGLGSMATICGIIKTIELNSIRDDPDFTWGLYAVTVWALSEIFVIITCGSVPALKPLWDRYIVRRFSENNSECHGNWFENYRMRHVYHARLQSGSAQARHTPKSESTSRSLWSSDPGVQTTTSTTKHFNINTAGERDIETIQEPQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7T5</accession>
    <name>B0Y7T5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_074930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7T5"/>
    <dbReference type="HOGENOM" id="CLU_013872_1_0_1"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7T5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000035">
        <property type="entry name" value="Putative ff domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000049">
        <property type="entry name" value="Transcription elongation regulator 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="566" mass="65455" checksum="FD4113A73FDC193E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y816</accession>
    <name>B0Y816_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase GliN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_075770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y816"/>
    <dbReference type="SMR" id="B0Y816"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075770"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="PhylomeDB" id="B0Y816"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000679">
        <property type="entry name" value="Methyltransferase GliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="282" mass="32189" checksum="07BDDB83CB407BB4" modified="2008-04-08" version="1">MTVLPDSENGYLLNYEDQEKRRMNMQHDLIKTYMGKLILAPLPFDQPNLRVLDSGTFNGLWLEDASTLLQSPTLVGTDVSPTAFPAKRPPNTEFHVQSISDPWPTEWRDSFDLVHQKLVIACVPPDEGRQALYRLIDLAKPGTGWVQFTEGSLEHLTPEQRKQYPVLARFQSLVAEMLPHFRWNPRPGKLVRQWLEEYGLQEVQEKVMEIPIGAGNPDPKLGEMAKQNMLEVVSNFRTAATRLPDGTGIRAEDFDPILRDIKVEFETVGGILRFNTVWGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8S8</accession>
    <name>B0Y8S8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_078410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8S8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078410"/>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8S8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122561" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="13">
        <location>
            <begin position="377"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP49809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="541" mass="57848" checksum="BF919803E96FD70C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8X0</accession>
    <name>B0Y8X0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_078840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8X0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078840"/>
    <dbReference type="HOGENOM" id="CLU_093534_0_0_1"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758295" evidence="1">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="256" mass="28476" checksum="3E719C2651591BC8" modified="2008-04-08" version="1">MATQSLLHYLSIALPAIPIQGAAPSRNTTNPRYGPDDITEVVTWQEFNYANILQQYGAILNAKQIRPDPFPSPPAAIRDEPQFHLRFAEMVLPRVRRALRAGFEQLAPQLPARQLSQITFDGGSAAALLDQFKPDTAYVVVGGNYANSTNRGPGDLKVSWKWKSSLRFSRVEADQNEYKQVLSQVNFYMKQHGARYGYILTNTEFVAVKRLNSNGRLAVANPIPWTSGSIGQPSVLLGLWYLGMLVAENNNWALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y971</accession>
    <name>B0Y971_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_079860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y971"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079860"/>
    <dbReference type="HOGENOM" id="CLU_015161_1_0_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="PhylomeDB" id="B0Y971"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="56"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="582" mass="65628" checksum="78DE1E821D7F8E14" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9F7</accession>
    <name>B0Y9F7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_080870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080870"/>
    <dbReference type="HOGENOM" id="CLU_1304605_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23310" checksum="45512F001854DAD6" modified="2008-04-08" version="1">MFSGLALGQNIVTIIVCRALLGLFGCVGTILVGGTFDDMYTPNQRAVPMATFSYIAILGTVGAPIYAGFIDETLGWRWISRKCSTIPPSKAIHILATKPALLGFGLWFSLAWFLTSSSSPSSPSPSRKKTPGARALPVGSTLYRPLQRHNLRLRAQLPPDQQIPLHRHRLRPRTNTRGTPLRRTARLYLAAYRTVLSTASRSSRSYIGFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9J9</accession>
    <name>B0Y9J9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N,N-dimethylglycine oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_081300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081300"/>
    <dbReference type="HOGENOM" id="CLU_007884_11_2_1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9J9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000015">
        <property type="entry name" value="N,N-dimethylglycine oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="381"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="438"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="746"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="847" mass="93347" checksum="37315A321AABC6A3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9K3</accession>
    <name>B0Y9K3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_081340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9K3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081340"/>
    <dbReference type="HOGENOM" id="CLU_2497465_0_0_1"/>
    <dbReference type="OrthoDB" id="4328771at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758323" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="86" mass="10290" checksum="30A0C1692CC16112" modified="2008-04-08" version="1">MQLSCLLALLGASRIAWAAPVANNNQVESASGDLEERFFYTNYDLEKRDEELDKRFFYTNYDLEKRDEELDKRFFYTNYGLEKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9L5</accession>
    <name>B0Y9L5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_081470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9L5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081470"/>
    <dbReference type="HOGENOM" id="CLU_019141_1_0_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9L5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760539" evidence="1">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="474" mass="52539" checksum="450884F3E24D2BDB" modified="2008-04-08" version="1">MELWTLLGLLAAIRHVQAKAVFAHFMVANAINFTQETWANDIAAAQAAHIDAFALNLGYGLHNYDLILNDAFTVAHRHNFKMFLSFDMGQGPQWPVDEIVHLIDNYATGGAYFKHHDDKPLVSTFEGGQNADVWKDVRHNAQSDFFFIPDWSSLGIEAASSSPVVDGLMSWHAWPAGAHDMNTTLDEEYIAALDGRPYIMPVSPWFYTNLPVFHKNWAWRGDDLWFDRWQQVLELAPEYVEIITWNDYGESHYIGPMHEDDLGIFAVGDAPFNYAEGMPHDGWREFLPYVIDLYKSGGRNASFDQEGVVSWFRLNPGSACLSGKTTPGQLSVQGTNTTSPRTIMQDRIFYSALLESAADVTVSIGGASKTGSWSDTPSGQKGLYHGSVPIDGMTGEVQVTLSRSGQQIAQMKGEVITTDCRKNHGYNNWNAWVGSAMGETMTAEKTSSNDKENGSQRSRPVMALLLGLVLLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9N8</accession>
    <name>B0Y9N8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1295 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_081730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9N8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081730"/>
    <dbReference type="HOGENOM" id="CLU_043418_2_0_1"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9N8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="354" mass="39292" checksum="762705496D7C65BC" modified="2008-04-08" version="1">MISSTVFSPVSSQCSSEQSRWSTSTDGHTNAPTSDSTLAMSVGIFKSTILPSFALHSSFSVAAYALSRATDRGEIKDYVWPLSQVANAWWSAVGEPMYLNNLTFSSALNAIPWTEKVLLSCVTAWGSRLFYRIVSRSLARGRDDPRYEELKAKDPGFWNSALLKSYLPEAAFLTLITLPFTLPFRMSWSSVSFDAETSGMLRALGVGLFTAGFAMEALADAQLELHRKERDDLCRHGVWSIVRHPNYLGDALVHLSFVVLNAANTFNPLVLLGPVANYVFLRFVGGDALNEASQEERYRMQDPHKYAQLLAWRREKNSFWPGLSELANPWTWAVVASGLVGVVVEEMVRSSLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9W2</accession>
    <name>B0Y9W2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_082470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082470"/>
    <dbReference type="HOGENOM" id="CLU_080767_0_0_1"/>
    <dbReference type="OrthoDB" id="2128064at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="70"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="208" mass="23296" checksum="484B70ED57603981" modified="2008-04-08" version="1">MLRIPSPFTSRLSTRRLLFSSRSVTHFQRLYTSQPQPQHQVTKCCSKKEKEKETEESVLTLSFWSSKQGWKRAAVNTLRCLAGCTLGDFSALWVLQSFYGHWGMSAIMGVSMASGITTSILLETVLLRRGVDKLPWGLAFRTATGMSLVSMLAMETVQNLVDYHLTGGVVLLDDPRFWAAALVSMGAGFLAPMPYNYWRLVKHGKSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA32</accession>
    <name>B0YA32_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb1 C-terminal repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_083240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA32"/>
    <dbReference type="HOGENOM" id="CLU_005288_2_0_1"/>
    <dbReference type="OrthoDB" id="6365728at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038799">
        <property type="entry name" value="LEKR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251:SF1">
        <property type="entry name" value="LEUCINE, GLUTAMATE AND LYSINE RICH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251">
        <property type="entry name" value="LEUCINE-, GLUTAMATE- AND LYSINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="502"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1142" mass="125348" checksum="E06C0721B07295C9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAZ7</accession>
    <name>B0YAZ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_086380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086380"/>
    <dbReference type="HOGENOM" id="CLU_003680_0_0_1"/>
    <dbReference type="OrthoDB" id="10057598at2759"/>
    <dbReference type="PhylomeDB" id="B0YAZ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01236">
        <property type="entry name" value="Haem_oxygenase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="782" mass="87177" checksum="6F9A4486143C006A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB32</accession>
    <name>B0YB32_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonucleoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_091390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB32"/>
    <dbReference type="HOGENOM" id="CLU_050545_2_0_1"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="PhylomeDB" id="B0YB32"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001114">
        <property type="entry name" value="Ribonucleoprotein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001675">
        <property type="entry name" value="Ribonucleoprotein, putative (AFU_orthologue AFUA_7G05810)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="171"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="289" mass="32031" checksum="7824BFAB40778EEA" modified="2008-04-08" version="1">MKGGDSPSAQSSGSPGPKTNSSRLTFSRPSSQVPQAISEGRRLYVGNMPYTAKSEDVQALFTAANFPIERIDIAIDPFTGRNPSYCFVDLETRELANKAMTELDGRDMLGRPVKIKPGVAKTASERSQQQQHQQQRTESSPRSDKGRPFALDHWRRNDTPAFAKVDSVSSRRLYVGGLPKLTDPEIITTNITNFFKGYKVENVSKLFTPHPAKRFEPGDHYYLFVEFSSTEEAQNAMDTLNGQEGPWGANLRVQRARGETSNSQERRNKWSSARDSNGAPATDDIAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB71</accession>
    <name>B0YB71_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_091780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB71"/>
    <dbReference type="SMR" id="B0YB71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091780"/>
    <dbReference type="HOGENOM" id="CLU_049747_0_0_1"/>
    <dbReference type="OrthoDB" id="10485024at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="446" mass="48490" checksum="7FB9C458519B0C50" modified="2008-04-08" version="1">MHPVLPSSTQGFCSAGLSCIIAQTLPINRVHACIPRPHTQICFPVQSATSCLMMDLSGQVHIHIKPSLHCRLHTDKICTLFWFPKYWTPTPESKYFRTVFSLLQLSCLPSSISGSIALALQACGFVFSGNGLLRLLTAEVEDDDCLLIEKVLAEDGNVDDPVYVTSGVKPGTVATYVATPDMVSRPVCFLQSLPTQPNPHTKAAEKKERMILLLSVKDNDLLNCHRFQPHSEEERWIEHPLDTTEPIILHKQSKMTSVSLVSGAHVFFQVPSGALVDLQYQHDTNRWTAQIMRTQVTVQPGSPLCAIQGPSSVSLFFVGDNNCIYYVTRSTVQDASEWEVLPGARFEQVPDGLLVVPDEGEPGAFISYVLLGSQLCKVDTTGEKPVGTIGEDGTFYPIDSQESAIIINIYCPTLFINGGLFGGGGAGGYGGGGGGGGWSMRGGRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB87</accession>
    <name>B0YB87_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_091940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091940"/>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="PhylomeDB" id="B0YB87"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="15"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="583" mass="67476" checksum="0E48DBFE8B4A2F6C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBD1</accession>
    <name>B0YBD1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamyl-tRNA(Gln) amidotransferase, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_092380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092380"/>
    <dbReference type="HOGENOM" id="CLU_020129_1_0_1"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="PhylomeDB" id="B0YBD1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="553" mass="60098" checksum="42F81C0658701BBC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBY2</accession>
    <name>B0YBY2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_088230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088230"/>
    <dbReference type="HOGENOM" id="CLU_1712836_0_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-ketoacyl synthase-like N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="153" mass="17562" checksum="70B78CA97BC9305A" modified="2008-04-08" version="1">MTTMSDKLEPLAIVGMKWRFSGEANSASGFWDVLTNARSAKSRIQADRFNVDAHYHPSADRNGSIIKEGHFLKEGIAASMRPSSQWQQRRQRAWTLSIAFFWRSLMRRLRMLGLSRDADRIPWLAALLETEIHTMSRTCQLVVVPACWRPDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC70</accession>
    <name>B0YC70_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_089140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089140"/>
    <dbReference type="HOGENOM" id="CLU_434725_0_0_1"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="PhylomeDB" id="B0YC70"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="629" mass="70177" checksum="18381193ED576207" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCP7</accession>
    <name>B0YCP7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin AspB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_090950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCP7"/>
    <dbReference type="HOGENOM" id="CLU_017718_8_3_1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="PhylomeDB" id="B0YCP7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032160">
        <property type="term" value="C:septin filament array"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="150"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="59258" checksum="D800049955337102" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDF0</accession>
    <name>B0YDF0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 105 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_095340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095340"/>
    <dbReference type="HOGENOM" id="CLU_110897_1_0_1"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="PhylomeDB" id="B0YDF0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000219">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 10.5 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP47684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="94" mass="10664" checksum="B4319EA7856C3033" modified="2008-04-08" version="1">MSSKYAFSKGLKELRFLFCQTSEQSAATRSFLQRAYPTMKKHNPQTPILIREAAGTLPRVYARYGFGKEKQESLSGLSDQQIEEKVSQLVKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDN1</accession>
    <name>B0YDN1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_096170</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096170"/>
    <dbReference type="HOGENOM" id="CLU_010365_7_1_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="PhylomeDB" id="B0YDN1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000061">
        <property type="entry name" value="Metalloreductase transmembrane component, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="358"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP47765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="735" mass="83478" checksum="68ADC3B3A809D84D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDT6</accession>
    <name>B0YDT6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_096730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096730"/>
    <dbReference type="HOGENOM" id="CLU_976801_0_0_1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="8">
        <location>
            <begin position="59"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="247" mass="27307" checksum="3EF04AE2F0BAD1D9" modified="2008-04-08" version="1">MPHLKVRDVDRKPYRQMLPRVLFNQCFILLPSMMLVQAMGYCFVGPTHLHPLRFLLSLLAMAVGHDVVQYVTHRYLLHNPNLRLMRLLQHSLHHSTGASRGISACYMSAPDFFLEIVLPYLVPLALVGGGGADLLFHSLVAGSGALGGVYEHSGYDFSALFSPENCMGGKGPWPSWTAKVAALIRGFVANRAHGEHHSRANVSFSDGFGSPGFCDTYFGTRWDLAAARRAAAEKEWQAQRSSHMNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDX8</accession>
    <name>B0YDX8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF453 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_097160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097160"/>
    <dbReference type="HOGENOM" id="CLU_026443_0_0_1"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="PhylomeDB" id="B0YDX8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="410" mass="43249" checksum="160CAAE7ABD4A3B4" modified="2008-04-08" version="1">MMVSRPLRWLLHPSPLRSQNVRVHRQFISSTAPLSKKQNSIPAAYYRGGTSRAIFFRKEDLPSEQQQWDDIFRGTIGSPDPYGRQLDGMGGGISSLSKVCVVSKSDRPDADVEYTFVSLGVKNMDVDYSSNCGNMISAVGPYAVDTGLFPVADDADVVSVRIFNTNTGKIIRSTFPVVDGEAAAAGGFAIDGVAGTGARIRLDFIDPAGSRTGKLLPTGKSVDCFDDIPASCVDVGNPCVFVRASDLGVPGNLAPDKIDAHPTLLSQLDSIRRQAGVKMGLAGTTKEVPGSVPKICLVSSPSDAYTSGMMQTPKDVDLVVRALSVGQPHKAVPITVALALATAARVSGTVVADVVSDKPVDPAGITLGHASGKLLVGADFDPTGHVSCATVYRTARRIMEGRVFWKGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE36</accession>
    <name>B0YE36_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_097710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097710"/>
    <dbReference type="HOGENOM" id="CLU_055646_0_0_1"/>
    <dbReference type="OrthoDB" id="4501024at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="322" mass="37108" checksum="EE84987B4A2595B5" modified="2008-04-08" version="1">MAPFGLNYLMFTLKVTEPSSTSKMFLSSLNPWSQSVSGRRGYIQGAHLIDLEKIRRLNDLLSQAREDASTTDKLHHQELNSLYRKISSFQVQHNTLNDEQILAEMRSLNQKLDLWVKYNFNDVRRLSALNCSEPGGQFPRSSTQRWAWIQGTITEMIFHYIFSPQHFGLDDNPWSQFLQYIEDGVEQAHSAVIQQNWRGVTCDAIEQSTRDVRESLMMEIITSVEEQFAEYSPMEETPRKRQLGELLQRCATFKDALSRQKDLFHFFRSQPGDDFSMTSMTFAGGCGDLAAKVRICLWPGLAKRTQNTTGCTFEPELVWTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE76</accession>
    <name>B0YE76_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_098200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098200"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="PhylomeDB" id="B0YE76"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003192">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="239"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="523"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="759" mass="84505" checksum="C04D107BB4B441BD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YED9</accession>
    <name>B0YED9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_098840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family. Class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YED9"/>
    <dbReference type="SMR" id="B0YED9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098840"/>
    <dbReference type="HOGENOM" id="CLU_004760_1_1_1"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="PhylomeDB" id="B0YED9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="788"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="832"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="996"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="296"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP47283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120968" checksum="60F0587AF2F09D0B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEL8</accession>
    <name>B0YEL8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_099630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099630"/>
    <dbReference type="HOGENOM" id="CLU_007003_7_0_1"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="PhylomeDB" id="B0YEL8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF83">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="641" mass="71544" checksum="FCCF4C965EA1AE39" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEW5</accession>
    <name>B0YEW5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_100730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100730"/>
    <dbReference type="HOGENOM" id="CLU_000022_6_1_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B0YEW5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000017">
        <property type="entry name" value="Non-reducing polyketide synthase aptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="391"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1310"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1699"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1310"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1473"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1673"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1678"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1776" mass="194144" checksum="F063636AB734DBA3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMB4</accession>
    <name>B0XMB4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_000430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000430"/>
    <dbReference type="HOGENOM" id="CLU_018502_1_0_1"/>
    <dbReference type="OrthoDB" id="3898179at2759"/>
    <dbReference type="PhylomeDB" id="B0XMB4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="68607" checksum="7EC7A6FF1C8D07C5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMD8</accession>
    <name>B0XMD8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase (Arc2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_001350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001350"/>
    <dbReference type="HOGENOM" id="CLU_107716_0_0_1"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="PhylomeDB" id="B0XMD8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000045">
        <property type="entry name" value="Arsenate reductase (Arc2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="158" mass="17733" checksum="11EC5827AD899896" modified="2008-04-08" version="1">MSAQPPTEQPWHAAFPAPRNTARSISREEMLQWMREGKQAGKDYVLVDLRRNDHEGGTIKGSLNLPAQSLYYSLSTVYNLLRAGGVKYIIWYCGSSTGRGTRAANWFADYLEDQQDGSIESLVLQGGIKGWVGAGEEYRELMEGFDAQVWQKNGIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMQ3</accession>
    <name>B0XMQ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_013770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013770"/>
    <dbReference type="HOGENOM" id="CLU_067863_0_0_1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="PhylomeDB" id="B0XMQ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021706">
        <property type="entry name" value="DUF2990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11693">
        <property type="entry name" value="DUF2990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760454" evidence="1">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="273" mass="29634" checksum="16DD2AF473C5518D" modified="2008-04-08" version="1">MQPFIVLFTWLMGTAYAAPAFFDNIYDYSDELAEFYSKVSKYIDDSKDVLTATTTCDPFKISLPAFASGLPSPGNQKPLYVAVGRGTQVSNNCTSRSHIRRMANVADPTQNYSCATSTTDSKPVAIGAVASLYNATCIAAGYSDMIDMLPNIVYKLQLPTNSWATLPYANLNLLGHHFFEGSVPVFNLDTTPQQQYGIVYTKKKADLAAPPSAVQGANGAVAWLYLTSTEGTVGDYESVYRVDTAGGSPPKTCENQPSVITVQYAANYYFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMT0</accession>
    <name>B0XMT0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridine nucleotide-disulphide oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_014050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014050"/>
    <dbReference type="HOGENOM" id="CLU_021377_1_2_1"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="PhylomeDB" id="B0XMT0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="54"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="7">
        <location>
            <begin position="472"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="545" mass="60802" checksum="4EF3F01F71C0A2E5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMW6</accession>
    <name>B0XMW6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_003550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003550"/>
    <dbReference type="HOGENOM" id="CLU_000631_7_3_1"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="PhylomeDB" id="B0XMW6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06591">
        <property type="entry name" value="GH31_xylosidase_XylS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="232"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="571"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="654" mass="75360" checksum="0E3B84E32DA6A916" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN73</accession>
    <name>B0XN73_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Heat shock protein Hsp98/Hsp104/ClpA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_014820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014820"/>
    <dbReference type="HOGENOM" id="CLU_005070_1_0_1"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="PhylomeDB" id="B0XN73"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="71"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="497"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="997" mass="111096" checksum="0E3C9914A99887BC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNE6</accession>
    <name>B0XNE6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_004670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004670"/>
    <dbReference type="HOGENOM" id="CLU_041441_2_1_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="B0XNE6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="371" mass="40026" checksum="479C82A3A44D9378" modified="2008-04-08" version="1">MVSPVELLFHLTYTDQGQATGIINSTPPVRALGNYNNHIQLSTLLNYPLTTTPTTRPLTRLLLISDTHNTSPHPPPSPHPYRHPLPEAHILIHSGDLTTIGSYQEHATTVATLKCHPAELKLIIAGNHDITLDEAYYAALPPSSFKTRSGREDPAAIKQLYCGPEAYDAGIRYLDEGVHCFSLSTGAELRVFASPYTPAFCSWAFAYPRGRDRFNPLPEDTTASSALSSAGADAPDGVVPDFPSVDIMITHGPPAGVLDSVVHGGSVGCEGLFAAVKRARPRVHVFGHIHEGYGALRGEWGPDMTLGGTKVVCDPDKVREERGAYVDVSADSGCPLRFGEETLFVNASVLNERYKAVNAPWVVDLDLPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNJ4</accession>
    <name>B0XNJ4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotidine 5'-phosphate decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_015360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015360"/>
    <dbReference type="HOGENOM" id="CLU_047844_0_0_1"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="PhylomeDB" id="B0XNJ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006222">
        <property type="term" value="P:UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48967" checksum="D7AA0C65C3C0E989" modified="2008-04-08" version="1">MESPTPFESFSFRGNRIIAYLQTLAKAKKGLPHGVPVCVSPSHTITNTESLLTLASLVGPHVAIFQVHADIIDDWSDETVRQLTLLAKRHAFLIWESGRILNATVDVVGKTTTESREVRNELVDLIRKKYTKGVVKAASWAGIATAWASGVTVGNQEADILIPTLKAAAREAVADSVQTIRTEITAVNAPTESLVNCHDDSESKDDTNADQQYLTLDYAVDESGLGPTLRKSSTISLTQTITQHTEDSTESLLDSTPHLITQDGIPETNFQNLSNSDDVPPPPLLARGLVLCLPSMTDTSFTPEYRRSCLAAARANPDFVLGFLCSEPWHLMSQTNDIFDLSSLQASEYEKGTSGETPAHLAIFSMISHKNGILNGREENDDESDEEVSPTTPLAPELPSRIMSPIATKLHDIVGQAVKLRDATIKHAVDGHASSGSLNAPRLLHIPVVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNZ3</accession>
    <name>B0XNZ3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_016190</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNZ3"/>
    <dbReference type="SMR" id="B0XNZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016190"/>
    <dbReference type="HOGENOM" id="CLU_009673_2_1_1"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="PhylomeDB" id="B0XNZ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="16">
        <location>
            <begin position="37"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="17">
        <location>
            <begin position="264"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="18">
        <location>
            <begin position="531"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="682"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="741"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="844"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP56897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="872" mass="96331" checksum="96B24FD4EB37B370" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP60</accession>
    <name>B0XP60_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_006040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP60"/>
    <dbReference type="HOGENOM" id="CLU_390272_0_0_1"/>
    <dbReference type="OrthoDB" id="6090458at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760361" evidence="2">
        <location>
            <begin position="19"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="678" mass="70816" checksum="CF3E281A150F1D63" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPQ4</accession>
    <name>B0XPQ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_007200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPQ4"/>
    <dbReference type="HOGENOM" id="CLU_026648_0_0_1"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="PhylomeDB" id="B0XPQ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="387" mass="44152" checksum="30160C3E007922EC" modified="2008-04-08" version="1">MDSPAAPVPFDPQEQPILERLLRTRDALLLLKQDKSSYIKSRDVLPLYEEVISEVEKLNARLLDHLEEAGFYSSKDLSSITKTLNNMKETVERGRDAYSPALMTLLESRLEQCQLKLNKLRSGLEAMNPELAPIHETLVSVLRSTAAANTRSKFSATEVINLRKQLTKIQDTMKDGNFIGADGKPLEGQEGVKQLLDRCWRWTEIVLEREGKIDERFRDQYERLLDIRNQLDRLSVTQAWSLRETDLFGYQRKLDRIDEARVDGNFVDAEGQLADIHAQRTLLYLIRRSYAYIYALLISSEPVSEALLPVYNQLQTLRRCLLEVKESGASLQGTEVDIVQLNSIDNMRVDGKFYMGNDIPEGQGSVNALLAECYDIVWELRAAVPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPX9</accession>
    <name>B0XPX9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_007940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007940"/>
    <dbReference type="HOGENOM" id="CLU_018738_1_0_1"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="PhylomeDB" id="B0XPX9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="592"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="740" mass="83619" checksum="9DB2CF29CB94B5B1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQB3</accession>
    <name>B0XQB3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_009350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQB3"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B0XQB3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="37"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="545" mass="61116" checksum="DD93ACAD0906B627" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQF0</accession>
    <name>B0XQF0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_009720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQF0"/>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_1"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="PhylomeDB" id="B0XQF0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="88"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="345"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="703" mass="79466" checksum="D157EFDDD23D247C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQI2</accession>
    <name>B0XQI2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_010050</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQI2"/>
    <dbReference type="SMR" id="B0XQI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010050"/>
    <dbReference type="HOGENOM" id="CLU_041802_0_1_1"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="PhylomeDB" id="B0XQI2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="122"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="244"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP56296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="387" mass="42196" checksum="8429D87D4E042B73" modified="2008-04-08" version="1">MGSVAKSNTFLFTSESVGEGHPDKIADQVSDAVLDACLAEDPLSKVACETATKTGMIMVFGEITTNAKLDYQKIIRGAIKDIGYDDSDKGFDYKTCNVLVAIEQQSPDIAQGLHYDEALEKLGAGDQGIMFGYATDETPELLPLTLLLSHKLNSAMTQARKDGSIPWLRPDTKTQVTVEYAHDGGAVKPLRVDTVVVSAQHSDDVSTEELRTVIKEKIIKKVIPAELLDDRTIYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYVGRWIAKSLVHAGLARRVLVQLSYAIGVAEPLSIFVETYGTSEKSSDELVEIIRKNFDLRPGVIVKELDLAKPIYFQTAKNGHFTNQSFPWEKPKTLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQV1</accession>
    <name>B0XQV1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_011260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011260"/>
    <dbReference type="HOGENOM" id="CLU_023116_0_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="PhylomeDB" id="B0XQV1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000580">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="688" mass="76131" checksum="1A95628B00408EB1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR48</accession>
    <name>B0XR48_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_001910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001910"/>
    <dbReference type="HOGENOM" id="CLU_2721743_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="72" mass="8018" checksum="EDA8C2DFF87D826F" modified="2008-04-08" version="1">MEAVVVLTDSVLASADENQRRLFHSEVELRAQIVSSLVTSHSHPSILNHLRESIHSIIILGFFQLLSGIIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRC2</accession>
    <name>B0XRC2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_012840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012840"/>
    <dbReference type="HOGENOM" id="CLU_001265_2_0_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="PhylomeDB" id="B0XRC2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="582" mass="66651" checksum="77A4E44AFEA9AC3A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRI8</accession>
    <name>B0XRI8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002620"/>
    <dbReference type="HOGENOM" id="CLU_1106886_0_0_1"/>
    <dbReference type="OrthoDB" id="4474853at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="252" mass="28928" checksum="9544F15EC527499C" modified="2008-04-08" version="1">MPASRIRWDDWKDKVMLMAVFEQMNTTSPDFKRVSKVMCGDYSARFEKPLQGLNKEAAAILRDRQRHAELREMTDEILPMMSGAVNSPEDKDVLVVREVTLRSELTPPASEQSPSMQSRRCPQQTERVMPEVITPNSQPSSIGRHTQSSGVQYQHHTSSEYDPNVHPARRPRCSHEATSTAGPYTHPRSSPQIPSRGRDFPRGQQERGWDQTLRTKNTGGRSFKPRNKNNRQRNFPQMTRVEINHGPVHTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XST3</accession>
    <name>B0XST3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_017520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XST3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017520"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="PhylomeDB" id="B0XST3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="235" mass="25504" checksum="ED7B410930DD458B" modified="2008-04-08" version="1">MGFVYSQLFVTPKYPTQEFPGRTVIVTGANVGLGLEAARHFCRLGAAKVILAVRNTAAGEIAEESIEKSTDRRGMCEVWELDLASYTSVQAFAAQASRQLSRTDILVANAGIATTQYTVAEGHERSLTVNVISTVLLAMLLLPKMRETALRFPSEIPHLSVVTSEVHAWTNLPEWKADDVFAALDNETTADHAIALCGLEASADSDCTGTRVEDGWFWGRSEHAPAWDVSFAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSX1</accession>
    <name>B0XSX1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_028090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028090"/>
    <dbReference type="HOGENOM" id="CLU_303488_0_0_1"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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            <end position="908"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP54749.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="916" mass="99231" checksum="C2BF5BA08F92D7DE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT24</accession>
    <name>B0XT24_ASPFC</name>
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        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">AFUB_028620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14797" checksum="321299D1D1E1EE1F" modified="2008-04-08" version="1">MRQDFLNTRTSPVQVLLPSKRPVLSFRHHIRSSHPTTTTTTTLSTRHRSRHRHVPYSFSEDAGLSAFCFPSSSHTISQRLRTLKRVPPELIPLGIVLSVAVGAAIYSSTRKLMTDKTLRLSRNKPEDREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT39</accession>
    <name>B0XT39_ASPFC</name>
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        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/reductase</fullName>
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        <name evidence="3" type="ORF">AFUB_017910</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="49311" checksum="DBB909691F84F549" modified="2008-04-08" version="1">MAAIFQSQKSALITGAASGIGFAIARVCRTKGMHLALLDVDTANLENARNELSALDPSLKTEIYTIDVGNRDAWKDIAKQIRSTFHDLDLIVLNAGKSYKAQSGLAGRLKPWADAEYWKKTFDTNVFGPLNGLETLLPLMTASSPTPKSIVITGSKQGITNPPGAANPAYNASKAAIKNLTEHLAHDLRSDPATAHISVHLLIPGWTWTGLMGNVGPTDESSLKKMEGAWFPSQVAEELVKGMEKGSFYIVCPDNETDRALDQARMQWASDDVVEDRPALSRWEDTWKGRAEEWIQNLKPSASDADMIRGCYGCGCALSLPDAARHYAGGFICAGSLLAHGECPNTRARITGTLCTAVATTGDLLASFDDDLLQIFVPCHVKRFTGLPFGFKIGPGETLIIITFGQHDVCLDTIVQLVGGTLASSASLRVSAMLDKSAISTPAAPGHFALASAARSWLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTR9</accession>
    <name>B0XTR9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">AFUB_029710</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 18"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029710"/>
    <dbReference type="HOGENOM" id="CLU_018693_4_0_1"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="PhylomeDB" id="B0XTR9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000403">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="150"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="474"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EDP54911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="565" mass="64630" checksum="836CFA6EC06D43DB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU51</accession>
    <name>B0XU51_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenite resistance protein Ars2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_030350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030350"/>
    <dbReference type="HOGENOM" id="CLU_014487_0_0_1"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="PhylomeDB" id="B0XU51"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF2">
        <property type="entry name" value="RESISTANCE PROTEIN ARS2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="917" mass="102639" checksum="FE5458D3AAE61840" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU59</accession>
    <name>B0XU59_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoprotease family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_030430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030430"/>
    <dbReference type="HOGENOM" id="CLU_004045_1_0_1"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="767"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP54982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="130209" checksum="425C4714812FFFB0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU90</accession>
    <name>B0XU90_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_019900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019900"/>
    <dbReference type="HOGENOM" id="CLU_043857_3_2_1"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="PhylomeDB" id="B0XU90"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="110" mass="12753" checksum="9F54B650227756E7" modified="2008-04-08" version="1">MGLAYNVYLTSNKIFGCKKCKTHLADYNDIISRNFRGQHGKAYLFNTVVNVTHSEAVERNMTTGRHIVRDIFCRQCAELVGWKYDKAYESSEKYKEGKFILEEELLCVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUA9</accession>
    <name>B0XUA9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA splicing factor (Prp8), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_020090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EDP53963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020090"/>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
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        <property type="entry name" value="PRP8_domainIV"/>
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        <property type="entry name" value="Prp8_domainIV_fingers"/>
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        <property type="entry name" value="Prp8_domainIV_palm"/>
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        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
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        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
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        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
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        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
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        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
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    <dbReference type="Pfam" id="PF05204">
        <property type="entry name" value="Hom_end"/>
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    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
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    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
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    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="8">
        <location>
            <begin position="2178"/>
            <end position="2254"/>
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            <begin position="1"/>
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        <location>
            <begin position="2094"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="1969"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2094"/>
            <end position="2113"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
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        <source>
            <dbReference type="EMBL" id="EDP53963.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="3170" mass="364678" checksum="1553CE33556439EB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUR7</accession>
    <name>PPZA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase ppzA</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppzA</name>
        <name type="ORF">AFUB_021020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="G3 (Bethesda)" volume="5" first="1525" last="1539">
            <title>Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Winkelstroeter L.K."/>
                <person name="Dolan S.K."/>
                <person name="Fernanda Dos Reis T."/>
                <person name="Bom V.L."/>
                <person name="Alves de Castro P."/>
                <person name="Hagiwara D."/>
                <person name="Alowni R."/>
                <person name="Jones G.W."/>
                <person name="Doyle S."/>
                <person name="Brown N.A."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="25943523"/>
            <dbReference type="DOI" id="10.1534/g3.115.016766"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Cell. Microbiol." volume="19" first="0" last="0">
            <title>Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence.</title>
            <authorList>
                <person name="Manfiolli A.O."/>
                <person name="de Castro P.A."/>
                <person name="Dos Reis T.F."/>
                <person name="Dolan S."/>
                <person name="Doyle S."/>
                <person name="Jones G."/>
                <person name="Riano Pachon D.M."/>
                <person name="Ulas M."/>
                <person name="Noble L.M."/>
                <person name="Mattern D.J."/>
                <person name="Brakhage A.A."/>
                <person name="Valiante V."/>
                <person name="Silva-Rocha R."/>
                <person name="Bayram O."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="28753224"/>
            <dbReference type="DOI" id="10.1111/cmi.12770"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalytic subunit of protein phosphatase Z (PPZ) involved in iron assimilation (PubMed:25943523, PubMed:28753224). Regulates secondary metabolites production, including gliotoxin, pyripyropene A, fumagillin, fumiquinazoline A, triacetyl-fusarinine C, and helvolic acid (PubMed:25943523, PubMed:28753224). Plays a key role in pathogenicity (PubMed:28753224).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with at least 54 proteins, of which 31 are detected only after iron starvation and 22 are detected only in control conditions (PubMed:28753224). Only the regulatory subunit of the protein phosphatase PP1 (Afu1g04800/AFUB_005140) interacts with ppzA in both conditions (PubMed:28753224).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5">Reduces sidC and sidG expression, slightly increases gliotoxin production, decreases growth in iron starvation conditions and leads to reduced conidiation at 44 degrees Celsius (PubMed:25943523). Reduces the production of pyripyropene A, fumagillin, fumiquinazoline A, triacetyl-fusarinine C, and helvolic acid (PubMed:28753224). Abolishes virulence in a neutropenic murine model of invasive pulmonary aspergillosis (PubMed:28753224).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUR7"/>
    <dbReference type="SMR" id="B0XUR7"/>
    <dbReference type="EnsemblFungi" id="EDP54052">
        <property type="protein sequence ID" value="EDP54052"/>
        <property type="gene ID" value="AFUB_021020"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021020"/>
    <dbReference type="HOGENOM" id="CLU_004962_3_1_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PhylomeDB" id="B0XUR7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000454887" description="Serine/threonine-protein phosphatase ppzA">
        <location>
            <begin position="1"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="2">
        <location>
            <begin position="258"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="25943523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="28753224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="25943523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="25943523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="540" mass="59548" checksum="140BF85438C54BC3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW49</accession>
    <name>B0XW49_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="16">LTA-4 hydrolase</shortName>
            <ecNumber evidence="16">3.3.2.10</ecNumber>
            <ecNumber evidence="16">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_023570</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="16"/>
    <dbReference type="EC" id="3.4.11.-" evidence="16"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW49"/>
    <dbReference type="SMR" id="B0XW49"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023570"/>
    <dbReference type="HOGENOM" id="CLU_014505_1_1_1"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="PhylomeDB" id="B0XW49"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 16" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="17">
        <location>
            <begin position="466"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="566"/>
            <end position="568"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP54301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="614" mass="69722" checksum="9380C62C0E262319" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWB8</accession>
    <name>B0XWB8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bactericidal permeability-increasing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_024260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024260"/>
    <dbReference type="HOGENOM" id="CLU_013290_0_0_1"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="PhylomeDB" id="B0XWB8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="229"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="585"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="84591" checksum="05F0A4363B4E237B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWD9</accession>
    <name>B0XWD9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_024470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024470"/>
    <dbReference type="HOGENOM" id="CLU_2120562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="114" mass="12556" checksum="0F21FC37CEEF4AE8" modified="2008-04-08" version="1">MSQQNVQLNSTGSVSPFQFQRIAVEIGRRLLPLHRSSDRACSIGEATQENVHGILRIPVRQGVFRQLPAGKAGNLFPAMGTETRETNRWIRSHILGHTSSVSNLAVELVLVNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWS2</accession>
    <name>B0XWS2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase, GNAT family family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_047120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047120"/>
    <dbReference type="HOGENOM" id="CLU_013985_6_2_1"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="PhylomeDB" id="B0XWS2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072:SF23">
        <property type="entry name" value="UPF0039 PROTEIN C11D3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="249" mass="27791" checksum="393374B9849A6D28" modified="2008-04-08" version="1">MTHRKYIPKPYTTPPQQMTRKSCYLEPTAAMSNIVLIPQEFPTVKERDKIVDLYKHLRLAGLKQDPEAFSATYETEAEFPHEKWLARIENPQARTFIALDDGETVPSTGNALTALLSSEWLGTVTIVGPRLAFSSEIDLSAPWRVFEEGDRYTTPQADDRNVVAVYMIAGMFVLPASRGMGNGRRLVEEAIRHTRGASPATEQTLLVLLVEANNEAARKLYERCGFQESNTEVVFGGQQTVGMVLNNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWZ5</accession>
    <name>B0XWZ5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_036950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036950"/>
    <dbReference type="HOGENOM" id="CLU_568547_0_0_1"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54067" checksum="CF4301D2CC788C47" modified="2008-04-08" version="1">MHNGYLTPHSPMSARTGLSPRRILFNSSLSLLGAFEFPEDYMYYEYSANGHLLGLLKVLPLPEILKSQPMSHHVYNAAMALAALTMSSFEPYSRGSIKLRRHAFHHSLKAIQGLNAELSSSSAAKTAVQSWNYDRILSLFATTMLLANFELQRGALLAWRSHMQGAALCLNTGYKQLRQTLAGMLLIRSFARMALLLRLYNKDYSVTSPETMPTRLSQWLDLLLKQSSQLQDRMLLLVEEVTALEIQKRQEPELDTFWSSKSSELLCKLDEWRTDVPIDEVPVDDDISRAYLTISSSDHASLIRVSALVFPNTRDPCTSAVNYVAYLCTCMRARTRYLPDSGRIVPPDAERTALTICRIAAGIPPTRFGESFTHSYGMLPSVVGAYRWSTNPGLRNWIKHWLAGYRGPREGIWNVQQTLKLLATMDSLPKPGWHFIALKVIDEPQEPSPDLDEAQSNEPFKVVLQARVQNATSTNVFVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX45</accession>
    <name>B0XX45_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_047690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047690"/>
    <dbReference type="HOGENOM" id="CLU_011226_4_1_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="B0XX45"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="117"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27921" checksum="80F180712097E6D4" modified="2008-04-08" version="1">MESNAQPTILFYDIASAPPVTCYAPNPWKIRYALNFKQAHYQTEWVELPDIPTVRKSLGLAANRVLPDGSPFYTLPIIKNLSTGELVGDSFEIAQYLDRLYPEGPRLLPPSTVGLISAFNSQVDAVFTQHCVLCVQGMPYNPATAEESKATFAKRAGKERYEDLMITGEARAGILESFQNALGELAKAYRRTEGPFLDGDTPTYADFIVGSWLNFYKKTIEEWEQLFGWHDGLWGELHRALEKYAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX61</accession>
    <name>B0XX61_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_047860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047860"/>
    <dbReference type="HOGENOM" id="CLU_758575_0_0_1"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="PhylomeDB" id="B0XX61"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="365" mass="40905" checksum="98AFD2BD3332C59E" modified="2008-04-08" version="1">MSTYVVSDQPLNNSFVGSISSLLSAAGVPNLLWGNYLLTVYGVPTIVDGVSFVVPDALLETGRSTLSYAGFLPCTQGPKCPYPNSAPCLETATHLHINDELVISLHRKSDVLWDFPDLEIGANSTDIMSAADTRLPPERLGRGQGRFPPSLSGVRIPSAVRYCEAMIRLLCLDSESPREPYWMAILTYLLEYVDETDIFQKNWLREGYRQFYEAMKQGDPEMYLHLRTLRDVFIKSSPQPSSLVSRLDDRLTIKHGRNSILTDLIALVFLPSSHILSIASFPKWQEKVQLMLRPAYGLLDQSIQPIQPFRVSPRKHTTNSAIVIAAMNLPCLKRFDGFYLVLSNSNFVSLAARIRESGPNIYKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXL4</accession>
    <name>B0XXL4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_037820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037820"/>
    <dbReference type="HOGENOM" id="CLU_126642_1_1_1"/>
    <dbReference type="OrthoDB" id="3827557at2759"/>
    <dbReference type="PhylomeDB" id="B0XXL4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="106" mass="12334" checksum="857F1AC4F95FEE3D" modified="2008-04-08" version="1">MSQVQQYWLPGYGLSRHIVLGHIQYFLGPSATVRPYTYQVNDYLEQINDLAAMSREYERQESLRMTGDVLSPHSCRESEPYINEIVPVRAFGHRRQPVDHGGRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXM0</accession>
    <name>B0XXM0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome component Prs2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_037880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXM0"/>
    <dbReference type="SMR" id="B0XXM0"/>
    <dbReference type="MEROPS" id="T01.971"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="PhylomeDB" id="B0XXM0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="258" mass="28204" checksum="623B6DC4316217C1" modified="2008-04-08" version="1">MTDTLPFSQTRVACTKSFSSICGPGPHQYAFKAITAANITSIGVRGKNCAVVLSQKKVADKLIDPSSVSHIFRLSPSVGCVMTGSIADARASVDRARGEAAEFRYKYGYEMPCDVLAKRLANINQVYTQRAYMRPLGVAMTLISVDDEKGPQLYKCDPAGYYVGYKATASGPKQQEALNYLEKKLKNKDYAEGSWEEVVELGITALSNVLSVDFKKHELEIGIVGGPRADGREGTDPSFRALTEDEIDERLQAISEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXV6</accession>
    <name>B0XXV6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_038710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038710"/>
    <dbReference type="HOGENOM" id="CLU_007957_0_0_1"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="PhylomeDB" id="B0XXV6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="477"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="816" mass="88460" checksum="A3B8C67CE0B472F2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXX2</accession>
    <name>B0XXX2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA replication protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_038870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXX2"/>
    <dbReference type="SMR" id="B0XXX2"/>
    <dbReference type="HOGENOM" id="CLU_011047_0_0_1"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="PhylomeDB" id="B0XXX2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000174">
        <property type="entry name" value="DNA replication licensing factor mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="10">
        <location>
            <begin position="348"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="9">
        <location>
            <begin position="504"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="551"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="687"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="739"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="792" mass="87634" checksum="0182501E2FDE87A2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY96</accession>
    <name>B0XY96_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_040130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY96"/>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_1"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="PhylomeDB" id="B0XY96"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="9">
        <location>
            <begin position="62"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="506" mass="56130" checksum="BB3C7EF0B32425AD" modified="2008-04-08" version="1">MSSLKDWRPMVACSSPKKSLRFLRDGRQNLAYRIMSLYISPSEIPSEDLQDIIRRSYATFRHPERTPLVELDGKRNLYLLELFHGPTFAFKDVALQFLGNLFEYFLVRKNEGKEGKDRHHLTVIGATSGDTGSAAIYGLRGKKDVSIFILFPTGRVSPIQQAQMTTVLDANVHNLTVEGSFDDCQDIVKALFADPDLNSTHNIAAVNSINWARILAQITYYFYSYFSLTKTSAFSKDTKMRFVVPSGNFGDILAGWFAKRMGLPAEKLVIATNENDILDRFFRSGGQYTKNTTQAEGVKETHSPAMDILVSSNFERLLWFLAFQADCAGSVDGRRKHACESVSNWLNQLKTQGGFTVPQAVLEGAKAEFESERVSNGETIDQIKSTYTSSFPSNLGPGSAKSSKTGGYILDPHSAVGVRAALRSIERNPGVKHISLSTAHPAKFASAVDLALRAEDGYDFTEVLPQEFIGLEQRESRVTPIRAGAGWVGVREVVKAEVEQELQGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ48</accession>
    <name>B0XZ48_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_043140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043140"/>
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        <property type="entry name" value="Ribonuclease H-like"/>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="1230"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="104"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
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        <location>
            <begin position="1186"/>
            <end position="1208"/>
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        <location>
            <begin position="11"/>
            <end position="29"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP53144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1420" mass="163591" checksum="E194A81AEFAFEF79" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZA1</accession>
    <name>B0XZA1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">R3H and G-patch domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_043670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
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    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="501"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="631"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="674" mass="75143" checksum="59EE9CC505BF8F88" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZA3</accession>
    <name>B0XZA3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SnoRNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_043690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZA3"/>
    <dbReference type="HOGENOM" id="CLU_002774_1_0_1"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="PhylomeDB" id="B0XZA3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000565">
        <property type="entry name" value="Putative snoRNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="65"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="597"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="682"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="856" mass="93229" checksum="A3F04F37C1D96BA0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZA9</accession>
    <name>B0XZA9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_043750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZA9"/>
    <dbReference type="HOGENOM" id="CLU_025955_0_0_1"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="PhylomeDB" id="B0XZA9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="667" mass="74089" checksum="B06BE1BF93DD757F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZE4</accession>
    <name>B0XZE4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_044120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044120"/>
    <dbReference type="HOGENOM" id="CLU_019787_0_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="PhylomeDB" id="B0XZE4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="704" mass="79242" checksum="976F56FD8827F4A7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZI1</accession>
    <name>B0XZI1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonribosomal peptide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_033950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033950"/>
    <dbReference type="HOGENOM" id="CLU_000022_0_12_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B0XZI1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000012">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000036">
        <property type="entry name" value="Nonribosomal peptide synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000075">
        <property type="entry name" value="Nonribosomal peptide synthetase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000066">
        <property type="entry name" value="Nonribosomal peptide synthetase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="776"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1826"/>
            <end position="1902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2353" mass="258536" checksum="765E3C0E2590D465" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-11-27" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZV3</accession>
    <name>SPHE_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyltransferase sphE</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Sphingofungin biosynthesis cluster protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sphE</name>
        <name type="ORF">AFUB_034490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Antibiot." volume="45" first="861" last="867">
            <title>Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.</title>
            <authorList>
                <person name="VanMiddlesworth F."/>
                <person name="Giacobbe R.A."/>
                <person name="Lopez M."/>
                <person name="Garrity G."/>
                <person name="Bland J.A."/>
                <person name="Bartizal K."/>
                <person name="Fromtling R.A."/>
                <person name="Polishook J."/>
                <person name="Zweerink M."/>
                <person name="Edison A.M."/>
            </authorList>
            <dbReference type="PubMed" id="1500351"/>
            <dbReference type="DOI" id="10.7164/antibiotics.45.861"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2022" name="ACS Chem. Biol." volume="17" first="386" last="394">
            <title>Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor.</title>
            <authorList>
                <person name="Bissell A.U."/>
                <person name="Rautschek J."/>
                <person name="Hoefgen S."/>
                <person name="Raguz L."/>
                <person name="Mattern D.J."/>
                <person name="Saeed N."/>
                <person name="Janevska S."/>
                <person name="Jojic K."/>
                <person name="Huang Y."/>
                <person name="Kufs J.E."/>
                <person name="Herboeck B."/>
                <person name="Guo H."/>
                <person name="Hillmann F."/>
                <person name="Beemelmanns C."/>
                <person name="Valiante V."/>
            </authorList>
            <dbReference type="PubMed" id="35023724"/>
            <dbReference type="DOI" id="10.1021/acschembio.1c00839"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acetyltransferase; part of the gene cluster that mediates the biosynthesis of sphingofungins, bioactive molecules acting as sphingolipid inhibitors via inhibiting serine palmitoyl transferase (SPT) (PubMed:35023724). Within the pathway, sphE catalyzes the O-acetylation of the C-5 hydroxyl group of sphingofungin B to produce sphingofungin C. SphE can also convert sphingofungin B1 into sphingofungin C1 and sphingofungin B2 into sphingofungin C2 (PubMed:35023724). Sphingofungin biosynthesis starts with the PKS sphB that produces an C18 polyketide precursor 3-hydroxyoctadeca-4,10-dienoyl-ACP containing one delta-6 desaturation and one delta-12 desaturation. The aminoacyl transferase sphA uses the sphB product to produce 3-keto-presphingofungin by adding an aminomalonate molecule. SphF then reduces the C-3 ketone of 3-keto-presphingofungin which leads to presphingofungin. The cytochrome P450 monooxygenase sphH converts presphingofungin into sphingofungin B1 which is further converted to sphingofungin B by the dioxygenase sphC. SphC is also able to convert presphingofungin into sphingofungin B2. The acetyltransferase sphE acetylates sphingofungin B to produce sphingofungin C, but can also convert sphingofungin B1 into sphingofungin C1 and sphingofungin B2 into sphingofungin C2. Finally, sphingofungin C can be spontaneously converted into sphingofungin D (PubMed:35023724).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>sphingofungin B + acetyl-CoA = sphingofungin C + CoA</text>
            <dbReference type="Rhea" id="RHEA:81171"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:231807"/>
            <dbReference type="ChEBI" id="CHEBI:231808"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:81172"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">Expression is positively regulated by the sphingofungins biosynthesis cluster-specific transcription factor sphG.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Leads to an increased accumulation of sphingofungin B.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="2">The sphingofungins A, B, C, and D, show a limited antifungal spectrum of activity but are especially effective against Cryptococcus species, fungal pathogens causing opportunistic infections in human.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZV3"/>
    <dbReference type="SMR" id="B0XZV3"/>
    <dbReference type="EnsemblFungi" id="EDP52285">
        <property type="protein sequence ID" value="EDP52285"/>
        <property type="gene ID" value="AFUB_034490"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034490"/>
    <dbReference type="HOGENOM" id="CLU_029797_2_1_1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="PhylomeDB" id="B0XZV3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000461281" description="Acetyltransferase sphE">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q70PR7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18404212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="35023724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="35023724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="515" mass="58264" checksum="CD5B12B24E370069" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-11-27" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZV5</accession>
    <name>SPHC_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dioxygenase sphC</fullName>
            <ecNumber evidence="5">1.14.11.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sphingofungin biosynthesis cluster protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sphC</name>
        <name type="ORF">AFUB_034510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Antibiot." volume="45" first="861" last="867">
            <title>Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.</title>
            <authorList>
                <person name="VanMiddlesworth F."/>
                <person name="Giacobbe R.A."/>
                <person name="Lopez M."/>
                <person name="Garrity G."/>
                <person name="Bland J.A."/>
                <person name="Bartizal K."/>
                <person name="Fromtling R.A."/>
                <person name="Polishook J."/>
                <person name="Zweerink M."/>
                <person name="Edison A.M."/>
            </authorList>
            <dbReference type="PubMed" id="1500351"/>
            <dbReference type="DOI" id="10.7164/antibiotics.45.861"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2022" name="ACS Chem. Biol." volume="17" first="386" last="394">
            <title>Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor.</title>
            <authorList>
                <person name="Bissell A.U."/>
                <person name="Rautschek J."/>
                <person name="Hoefgen S."/>
                <person name="Raguz L."/>
                <person name="Mattern D.J."/>
                <person name="Saeed N."/>
                <person name="Janevska S."/>
                <person name="Jojic K."/>
                <person name="Huang Y."/>
                <person name="Kufs J.E."/>
                <person name="Herboeck B."/>
                <person name="Guo H."/>
                <person name="Hillmann F."/>
                <person name="Beemelmanns C."/>
                <person name="Valiante V."/>
            </authorList>
            <dbReference type="PubMed" id="35023724"/>
            <dbReference type="DOI" id="10.1021/acschembio.1c00839"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Dioxygenase; part of the gene cluster that mediates the biosynthesis of sphingofungins, bioactive molecules acting as sphingolipid inhibitors via inhibiting serine palmitoyl transferase (SPT) (PubMed:35023724). Within the pathway, sphC catalyzes the hydrolxylation at C-4 to convert sphingofungin B1 into sphingofungin B as well as presphingofungin into sphingofungin B2 (PubMed:35023724). Sphingofungin biosynthesis starts with the PKS sphB that produces an C18 polyketide precursor 3-hydroxyoctadeca-4,10-dienoyl-ACP containing one delta-6 desaturation and one delta-12 desaturation. The aminoacyl transferase sphA uses the sphB product to produce 3-keto-presphingofungin by adding an aminomalonate molecule. SphF then reduces the C-3 ketone of 3-keto-presphingofungin which leads to presphingofungin. The cytochrome P450 monooxygenase sphH converts presphingofungin into sphingofungin B1 which is further converted to sphingofungin B by the dioxygenase sphC. SphC is also able to convert presphingofungin into sphingofungin B2. The acetyltransferase sphE acetylates sphingofungin B to produce sphingofungin C, but can also convert sphingofungin B1 into sphingofungin C1 and sphingofungin B2 into sphingofungin C2. Finally, sphingofungin C can be spontaneously converted into sphingofungin D (PubMed:35023724).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>sphingofungin B1 + 2-oxoglutarate + O2 = sphingofungin B + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:81167"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:231806"/>
            <dbReference type="ChEBI" id="CHEBI:231807"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:81168"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is positively regulated by the sphingofungins biosynthesis cluster-specific transcription factor sphG.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Leads to the production of derivatives lacking the C-4 hydroxyl group.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="4">The sphingofungins A, B, C, and D, show a limited antifungal spectrum of activity but are especially effective against Cryptococcus species, fungal pathogens causing opportunistic infections in human.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="5"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZV5"/>
    <dbReference type="SMR" id="B0XZV5"/>
    <dbReference type="EnsemblFungi" id="EDP52287">
        <property type="protein sequence ID" value="EDP52287"/>
        <property type="gene ID" value="AFUB_034510"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034510"/>
    <dbReference type="HOGENOM" id="CLU_047725_1_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="PhylomeDB" id="B0XZV5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF19">
        <property type="entry name" value="MULTIFUNCTIONAL DIOXYGENASE AUSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000461279" description="Dioxygenase sphC">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A097ZPD9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q4WAW9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18404212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="35023724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="35023724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="363" mass="40853" checksum="B6870E32FAF24947" modified="2008-04-08" version="1">MRPPIHKLICKRLADQSSHHSQHLYHQYIVRNLPAVLQMWRIPTDVPQVAVPIGLKLAEVTADTPLDEVFKHWKESGGVILKNILTPAEAHQITTELESRIDSVQRGSRVPHEDLAAFHGAKTKRAGDLINHSATFRERILENDFIHAICQRCFGEDGHNGDYWLSAATTLNASGPQPAQVLHRDLTSYPPYALLGPEGTEPQINFLFAFSDFTDDNGATRIIPGSNKWPFHQRGNMAQTIPAEMKTGDCLLIGGKVIHAMGENKTETERKCIQLTVIPSFLTPAEAHPFIIKLETVKKLSKRAQRFVGFRSQYPRGSPGLWTKDYIELALHLGLDDLQGAMEDLQHVLNQPKQWDTIDYDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y022</accession>
    <name>B0Y022_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_045350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y022"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045350"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="PhylomeDB" id="B0Y022"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="294" mass="30868" checksum="727D91E9DB1412DD" modified="2008-04-08" version="1">MTPTAIDDVAAAASLPNTQQQHTSSAPTVPSLLSLTGKTIAITGGGRGLGMELAFAVVESGGHVACLDILPSPSETQWSTLLKLCKSSNLTASYTQCDVTSETELATALEQIAQDADARGAPFSGVVASAGIQQKVPALEYEGQDFERILRVNVTGAFLTAKRTARILVEKNRPGSIVLIASMSGQIANRGLTCSAYNTSKAAVQQLCRSLAQEWGKYGIRVNTLSPGYIMTDMTNQLLQAEPEVEKTWMAGALLGRLSTPVEFKAPAVFLLSEGSSFMTGADLRVDGGHCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y028</accession>
    <name>B0Y028_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isopropanol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_045410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y028"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045410"/>
    <dbReference type="HOGENOM" id="CLU_026673_0_0_1"/>
    <dbReference type="OrthoDB" id="5407715at2759"/>
    <dbReference type="PhylomeDB" id="B0Y028"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF17">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758086" evidence="6">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="343" mass="36908" checksum="F3C58499B872FF67" modified="2008-04-08" version="1">MATHQAIILPGINLPLTLASVPTPAPQSGQVLIKVLASPILAYYRAILTGKRPYPLSLPLTPGVSPIGRIEATGSDTTALKPGQLVYVDLAVRARDDPLKEHGTIVLQGLFVGITPEARILSENDWRHGSWAEKQLVPLENVHVLDESLLCAQMGYSPARLTWINTLLVPYGGLLSGALQPGRRSVEKIQSRYPKGKVVGVATEGLNETSLKDAMRKATPRGLGADLFLDFTPSSAAEGQKWIHLASAISALKANGRAVLMGGASDAVSLPYSVLMMRNITVKGNFMFDGTAPVKLIRLIETGNLSLSRFHDIEFDFKDYERAIDEAATKTAGDCGVVLVHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y042</accession>
    <name>B0Y042_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_045560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y042"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045560"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B0Y042"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF155">
        <property type="entry name" value="EFFLUX PUMP AFOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="577" mass="61260" checksum="90659C951090E7D8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0J4</accession>
    <name>B0Y0J4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromatin structure remodeling complex protein RSC3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_046430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0J4"/>
    <dbReference type="HOGENOM" id="CLU_013296_2_1_1"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0J4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF53">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="738" mass="81997" checksum="9027C3413A1CEE3C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0K6</accession>
    <name>B0Y0K6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Cytochrome b5 reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_057650</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057650"/>
    <dbReference type="HOGENOM" id="CLU_003827_0_1_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0K6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="227"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP51747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="471" mass="51241" checksum="AB4F42B90A033103" modified="2008-04-08" version="1">MMTEFTVADVAGHKTRDDLWVIIHGKVYDLTKYIRDHPGGADVLLDVAGTDATAAYEDVGHSEDADDIMQTYLVGTLKDATRFVRKSAVRVIQPTSVPVAKDNSSSRVGKVAAAGSVAGLLSLLYYVPPRHGSLQLPHALYQLQAYLPSLHRLLPSSMTGMRLPQGGFANGFAAAALLSAIITGIVGMQVSKLTKIDSGFTRYPPRIKSKPSPKADPHSIPGFLNPKDYKTLPLVQKALLAPNVYRFVFQLPSATDIVGLPVGQHVAIKATVDGQTVTRSYTPTSNNLDRGYLELVIKCYPDGLLTGQYLANLQVGDKVHFRGPKGAMKYQRNLCKKIGMIAGGTGITPMYQLIRAICEDDKDTTEISLVYANRSEGDILLREELEAFARRYPKQFQVYYMLDVPPENWTYGKGYVTPAVMAARLPKPAADTKIFLCGPPGMINAAKKGLVSLGFEAPGAVGKMTDQIFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0M9</accession>
    <name>B0Y0M9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aflatoxin regulatory protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_057880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0M9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057880"/>
    <dbReference type="HOGENOM" id="CLU_1245083_0_0_1"/>
    <dbReference type="OrthoDB" id="4482965at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23079" checksum="8CB6B31D45175D25" modified="2008-04-08" version="1">MTTTCPCPAQIKHLASTLPTKGPFDFSFLPTLPQPLADLCRSIEACQHPSHKSNPDLSPPLVDLSDAVLSLCHAACTTYHLLDDELGSTTSNGNGNGTTTTTATSPPTQTGNANPPLTCTKSPMSLGKLTLQAEEETLLARQVVYAVLERLSTLLRGVYARGKGAAGGGPAIGATATATVVMDLDLGMALGTRQGLYGREGDEPVSQCLSRGLALLGKLFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0P1</accession>
    <name>B0Y0P1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="7">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_058010</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="7"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0P1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058010"/>
    <dbReference type="HOGENOM" id="CLU_003827_4_2_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0P1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000197">
        <property type="entry name" value="Nitrate reductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000008">
        <property type="entry name" value="Nitrate reductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="658"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="769"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP51782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1026" mass="117442" checksum="2E8D7DE6E85C6243" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0Q2</accession>
    <name>B0Y0Q2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl hydrolase family 92 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_058130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058130"/>
    <dbReference type="HOGENOM" id="CLU_145517_0_0_1"/>
    <dbReference type="OrthoDB" id="4451618at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF38">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="1">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="156" mass="17354" checksum="DCB0036190DA4D6E" modified="2008-04-08" version="1">MFNIPYLYNYVNRQDLSVAQSRKVAKKYFNTGVAGLPGNSDAGAMQTWLLWNMIGLYPITGQTTFLIHSPWFESLTIDLGGGKQLRVTATGGDGNGDSKIYVQSLKVNGNPWRKNWLTWHDVFENGGTLEFELGESPSGWFTDGKSGVRTHATFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1L7</accession>
    <name>B0Y1L7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2278 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_049740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049740"/>
    <dbReference type="HOGENOM" id="CLU_1460965_0_0_1"/>
    <dbReference type="OrthoDB" id="2580841at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20936" checksum="3B3B67D61EF9383C" modified="2008-04-08" version="1">MEISWLFRAAINIKSGDTNDSRLVYWIDRDFSQHSIIDRLSVLKPGFHLLEDTKSSPDGPRVGFIRSNLFNVNSGRVLPQNIEGPDNNIIDLLEPEVRQAIERQAEVYVFGARFDTKDGIHDVHMNQGNKGRWKGITPSFKTEHSLFISQILTDGLAFSSALHPRQPIPMIGLGMPYHRRLGVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1Q7</accession>
    <name>B0Y1Q7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_060460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1Q7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060460"/>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1Q7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="162"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="588" mass="65623" checksum="759F77157E7F6354" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1R4</accession>
    <name>B0Y1R4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_060530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1R4"/>
    <dbReference type="HOGENOM" id="CLU_048909_0_0_1"/>
    <dbReference type="OrthoDB" id="5378435at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="392" mass="42483" checksum="0C75E234F50413E2" modified="2008-04-08" version="1">MADCWQSQASVAGPYWISPGNQPCLRTSTFRDLMYAFPRPKHTSRVMKPRSAGNSPSSAAKRRATTSHTSPMYRQLPLQSYQAQIQAALAASAMRRTRQPRPMSWHPASMRSTGYSTPQYLPSTTTSENLAGSGLCASSSNTVPVTYQGEDILPVYPASDAAMFSSLSGMEDPTIMQQQYILQTNGSQAEPVTWDASVSSLSAMALPMSEGWSFDMMSMNSSIPGADVAGSNYESAPSSGPPTPFLPIQQFDEPEAVEEKPEDELVGMGLYSHPDTSLNASLTGLSGKGLKLEETFTPSPDDEAENQDADGEDDDSQETAEKQASNSADLHQPQLELQTHAQPVKSAQNMLNKSFFFEDDGGLDQDGDGGVTTQQFFGLENQPCMNYAYGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1R5</accession>
    <name>B0Y1R5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD+ kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_060580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1R5"/>
    <dbReference type="HOGENOM" id="CLU_008831_1_1_1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1R5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="485" mass="54551" checksum="A5DCB011576EC58E" modified="2008-04-08" version="1">MEKGLSQDDTVVLYPDCTHRRKSSLVSVDDSRSRPHLDNTDERTACFVHSLIMGEWISPPSKDIRPDAKPSKAHGTTPQTTVVDDDAIKPSEAKDRKALKTTPTVVQSRHLTKKQLSDMAWNVRKLSKKLGSIKLKLTVKSVLLVTKVRDESLVVLTRKVTQWLLSKDRSTKYVVYVEKRLETHPDFGATQLLQEEPTAEGRLKYWDADMASEEAHLFDFVVTLGGDGTVLYTSWLFQHVVPPVLSFSLGSLGFLTRFDFNQYQSTLETAFKDGVVVSLRLRFECTIMRSNRRSEDDATNITKRDLVEELIGEEMEGTLTHRPDKVFQILNDVVLDRGPNPTMSQIELFGDNEHFTTLLADGVCIATPTGSTAYNLAAGGSLCHPENPVILVTAICAHTLSFRPIILPDTIVLRMGVPYDARTSSWASFDGRERIELQPGDYVTVSASRYPFANVLPHNRRGEDWVQSISKTLNWNSRQKQKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1W7</accession>
    <name>B0Y1W7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_050090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050090"/>
    <dbReference type="HOGENOM" id="CLU_004083_5_0_1"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1W7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="689" mass="78447" checksum="4B6A0A7A82FBB5B6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y210</accession>
    <name>B0Y210_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_050520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y210"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050520"/>
    <dbReference type="HOGENOM" id="CLU_036729_0_1_1"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="PhylomeDB" id="B0Y210"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.10:FF:000031">
        <property type="entry name" value="Proline racemase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="401" mass="44041" checksum="9441B78596823111" modified="2008-04-08" version="1">MDIVQFLEETSSNQPIRCIDMHTTGEPTRIIYSGFPPLSGTLLEQRDQAKQHHDHIRKCLMLEPRGHNGMYGAIIRPETELVSSGAAHIGVLFIHNEGFSTMCGHATIALGRFLVDTHDYSVFPRRQDLVFEADTQTVKLDIHAPCGVVRVTVPVTADGRKSDPSRPVTFLSTPAFATRIQMTVPIAPEIRWPELRDRDSIVLDISYGGAFYAIVQASELGFSGGLRDLDLDAMTRCIQKLKPCLMGLAEVQAAVQHPHDQRLAFLYSVMIVDDTLGFQPDDVQGAETGLCYFAENQIDRSPTGSCVIARMALAYAKGLRSLGQRWAYNSLVSNRFGTGAFSAEIVEEVTIDKIDGGCLNAVVVQVEGQAFYTGASVFAVEHEDRISSSGFTMEEVAVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2K2</accession>
    <name>B0Y2K2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_062110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062110"/>
    <dbReference type="HOGENOM" id="CLU_015502_1_0_1"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2K2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="606" mass="67383" checksum="56E8BFBDDE51D11A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2L7</accession>
    <name>B0Y2L7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_062270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062270"/>
    <dbReference type="HOGENOM" id="CLU_087059_3_0_1"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2L7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G14600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="240" mass="27384" checksum="3AF69FE8AFFE3A36" modified="2008-04-08" version="1">MDGLDFDTAPVEFQKVRWIVETPLIIAGMGWTLNYFFTIRKAYQDRMSGVSLIALSNNLAWEIAFALINPPPNPLARVNYPLWLSVNAFVLYATVKCERESGLHSPFMRRHLPFIVLISILGLLSGHLAFSSHVGPLAALFWGGMFCQVTLSASALGLLLQRGHTRGMSYKMWLTRFIATGVTVPGLFVRAAYWPEKWDWVNNVLMYWLVGAFYCLDIAYGMCLWYFRRLERMSSRVKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2V8</accession>
    <name>B0Y2V8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_062530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2V8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062530"/>
    <dbReference type="HOGENOM" id="CLU_061199_2_1_1"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2V8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30022" checksum="0991F2B92117D2BF" modified="2008-04-08" version="1">MGQTTSIPKPGTQIQVIGAGLPRTGTTSLSMALAILLDAPVYHCNTQTTRGPPSELKSWIRILHAWLEGDRPTVLAALKSCLTGFAAVTDTPACHLLPELLELYPDAKVVCTVRDPLAWEKSMKQAHGLTRTWFLKALLFPLPGMRHFVDFTWLLRRQWSRLYADGRHLNSVNEVAATLPQRETYSRHLAWLKENVPPHQLIFFDVREGWEPLCRALGKDVPKDVPFPHENDSVGIERTAKYHIRRALMRWAGMFALTGVIIIAGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2W3</accession>
    <name>B0Y2W3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Telomere-associated RecQ helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_062580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2W3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062580"/>
    <dbReference type="HOGENOM" id="CLU_1767640_0_0_1"/>
    <dbReference type="OrthoDB" id="4505768at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="147" mass="17177" checksum="7BAFE7E9A460CE6F" modified="2008-04-08" version="1">MRWCRCGSRRRPPVDRPLLNPRSSTTVEAPDPNTANPVEQGVLILYHTVDQLARKSQRTVTYCGQAIYMEAVCTQAAELPHQPLLAYMDATSVWKHVQLWQQILGFFARMQHPQAWQSPVYQFTAWQQQKWARLWQLVQHPKPQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y352</accession>
    <name>B0Y352_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_052970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y352"/>
    <dbReference type="HOGENOM" id="CLU_074609_0_0_1"/>
    <dbReference type="OrthoDB" id="5424692at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="239" mass="26102" checksum="DF7EEBCFB8ABC964" modified="2008-04-08" version="1">MPPTSVQIAAQSNDRSVPDSKLGRPENNPEPADAISSTTPQSGPRAVCSSYGQTALPNISAGPKPSFNARGSMISLLSAPTRPRGNLNPKDFARSTRRGQVSISQAAPPTGPRNGHIPTGPSVDSDRQHIYRQNSFSGTSYPRQRPTNYLASLNTIVPGGRFLTHDLDTAVEKRLAQLEMDKERLYEQIADSQRLKHVVIRDWERLDRESSICALKSELAEGHLLCITDGESMHTSTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y390</accession>
    <name>B0Y390_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_053350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y390"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053350"/>
    <dbReference type="HOGENOM" id="CLU_134505_2_0_1"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="PhylomeDB" id="B0Y390"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="102" mass="11028" checksum="8982B6AD594DEAAA" modified="2008-04-08" version="1">MDDILAPIQDAFEGQIDFYGQRIAELLSTALLLISGVAAFLIGYIYEDIHLTLWTGLAGTLVTALAVIPPWPMYNKHPEKWLVPMTGSADGPGIMVDGVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4K4</accession>
    <name>B0Y4K4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sulfate transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_069400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069400"/>
    <dbReference type="HOGENOM" id="CLU_003182_0_2_1"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4K4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000141">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="619"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="690"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="907"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111413" checksum="AFB0DBD11CF388E1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4S1</accession>
    <name>B0Y4S1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_070070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4S1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070070"/>
    <dbReference type="HOGENOM" id="CLU_943336_0_0_1"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4S1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="295" mass="33127" checksum="C46257D5E56992AA" modified="2008-04-08" version="1">MSAQRLFQRLSRPSRSSFSFTTAISRRSFGSSAVRLNDGDGKDRAPSTAPEHRKYQTSRPPNPAVPHSTSTMTNDFPSVGERTPPPEVLSSVDPNYKPVDPYPGRVEHYTGGRQQPGAQKPELGVGEMEGITFKVEPLRRTGEDPATMRARLLYQSRKRGILESDLLLSTFADVYLKDMTPEQLQEYDRFLDENDWDIYYWATQDPPSATDSPAEDTVTETWKRTGAKSGEWKQTVGAYKAAYRPVPSRWADSEVLRLLRQHVRDKSAVGFHAAKNKKTGGCGLGRMPDIQVFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4U8</accession>
    <name>B0Y4U8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_070370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4U8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070370"/>
    <dbReference type="HOGENOM" id="CLU_021322_5_3_1"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4U8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000030">
        <property type="entry name" value="RNA methyltransferase, TrmH family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000035">
        <property type="entry name" value="TrmH family RNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="484" mass="53222" checksum="49736BA3DD18AD78" modified="2008-04-08" version="1">MLLNVPLRTLGTCLSRAPSNPLRSIRNASLTSAIGRGIRKTRSVEGRNEPQKSSTGDSDQSRGGRHFGRSDSRRDVGIKAFDEEEFIKTGRLRELRSEQGADLPEPKRPRIQTHERAKTIKEHRKERDLQDRSRLKRGEIRFTEGEPEQQKKHVLVPDSVPYTTPASEFIYGTSAVEAALRSGRRQLYKLYIYQGDNEELGPTRSMLRKLALSKNIKVKMAYAGWDRLFDQMSSGRPHNGCILDASPLPQLPVKSLCATPTLGADEFRVVLAPQSKEEAMVNSTNNRVPVRHLPGQSRYPVVLLLDGITDTGNLGGIIRSAYYLGIDAIVFAGRNCAPLSPITIKASAGAAENMPLIKVSNEVDFIQQSKANGWRFFAADAPLPGTRYPDTTGDIDLTRNAVTQAPSVIMLGSEGSGLSGHIKSHADSIVSIPGARNATEWGYEKDPARVDSLNVSVAAAILMEQFLRIPILITEAPPRKAVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4Y4</accession>
    <name>B0Y4Y4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">exo-alpha-sialidase</fullName>
            <ecNumber evidence="3">3.2.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_070730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of alpha-(2-&gt;3)-, alpha-(2-&gt;6)-, alpha-(2-&gt;8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.</text>
            <dbReference type="EC" id="3.2.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.18" evidence="3"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4Y4"/>
    <dbReference type="SMR" id="B0Y4Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070730"/>
    <dbReference type="HOGENOM" id="CLU_024620_1_0_1"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00260">
        <property type="entry name" value="Sialidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.10:FF:000008">
        <property type="entry name" value="Exo-alpha-sialidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628:SF30">
        <property type="entry name" value="EXO-ALPHA-SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758632" description="exo-alpha-sialidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="10">
        <location>
            <begin position="70"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="406" mass="44414" checksum="45D8820EE1EF671A" modified="2008-04-08" version="1">MQSMRFMILALLVQFLPAWAINDPAKSAAPYHDEFPLFRSANMASPDKLSTGIGFHSFRIPAVVRTTTGRILAFAEGRRHTNQDFGDINLVYKRTKTTANNGASPSDWEPLREVVGSGAGTWGNPTPVVDDDNTIYLFLSWNGATYSQNGKDVLPDGTVTKKIDSTWEGRRHLYLTESRDDGNTWSKPVDLTKELTPDGWAWDAVGPGNGIRLTTGELVIPAMGRNIIGRGAPGNRTWSVQRLSGAGAEGTIVQTPDGKLYRNDRPSQKGYRMVARGTLEGFGAFAPDAGLPDPACQGSVLRYNSDAPARTIFLNSASGTSRRAMRVRISYDADAKKFNYGRKLEDAKVSGAGHEGGYSSMTKTGDYKIGALVESDFFNDGTGKNSYRAIIWRRFNLSWILNGPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5N8</accession>
    <name>B0Y5N8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_064040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5N8"/>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5N8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="565" mass="60757" checksum="4C271DA5BD99B496" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Q0</accession>
    <name>B0Y5Q0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_064170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Q0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064170"/>
    <dbReference type="HOGENOM" id="CLU_023312_0_2_1"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Q0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000104">
        <property type="entry name" value="Dual specificity phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="349" mass="38267" checksum="C4F3635C7F803BC1" modified="2008-04-08" version="1">MAMNKIPGHDIYIGGILAVKNKAALSRANITHIVSVLRLNQPDEIFANFQHHCIHADDVGDENLLEHFPSAIKFIQSGLDAGGSVLVHCAMGKSRSATICIAYLLHQQPSALTPQSALALLRKGRPLCEPNDGFMEQLALYHEMGCPDDVTGHPLYNRWLYRREVEDSVACGRAPEMQSVLFEDEQPHRPQETSDRLTEIKCRKCRRTLATTPFIIPHGPRQNNKATECAHIFLHPLTWMRPSLFPNTTTDSEATEYGSRPDDAPLSGRLTCPNTACGANIGKFAWQGMQCNCGEWVVPAIGLAKARVDISDRFNMARGPGGLPPAAFGIRMPPGMRAPDDSGAGRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5W9</accession>
    <name>B0Y5W9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_064860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064860"/>
    <dbReference type="HOGENOM" id="CLU_009646_3_1_1"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5W9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990818">
        <property type="term" value="P:L-arginine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089708">
        <property type="term" value="P:L-histidine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089707">
        <property type="term" value="P:L-lysine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
            <begin position="709"/>
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            <begin position="344"/>
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        <source>
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        <source>
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        <source>
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    <sequence length="744" mass="81472" checksum="951C0B8548694902" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5X1</accession>
    <name>B0Y5X1_ASPFC</name>
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            <fullName evidence="3 19">Mevalonate kinase</fullName>
            <shortName evidence="19">MK</shortName>
            <ecNumber evidence="3 19">2.7.1.36</ecNumber>
        </recommendedName>
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        <name evidence="23" type="ORF">AFUB_064880</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
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    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="24">CBS 144.89 / FGSC A1163 / CEA10</strain>
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        <text evidence="19">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
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            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:456216"/>
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    <comment type="pathway">
        <text evidence="18 19">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 19">Cytoplasm</location>
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    <comment type="similarity">
        <text evidence="2 19">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
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    </dbReference>
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    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
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            <begin position="1"/>
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        <location>
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    </feature>
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        <location>
            <begin position="50"/>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EDP50156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="538" mass="58396" checksum="3CCDF639D6F28F52" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6D2</accession>
    <name>B0Y6D2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_066520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6D2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066520"/>
    <dbReference type="HOGENOM" id="CLU_029272_1_0_1"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6D2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760835" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="63137" checksum="3F010E248E541C9D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6L2</accession>
    <name>B0Y6L2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylglycerophosphatase GEP4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_067350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6L2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067350"/>
    <dbReference type="HOGENOM" id="CLU_056221_3_0_1"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6L2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000251">
        <property type="entry name" value="Phosphatidylglycerophosphatase GEP4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34338" checksum="AB9485204131FFBA" modified="2008-04-08" version="1">MASTPNTNLRGFNHAVQTLLRNPSQFLPHLTIPTFTHLPEQLGPHLHRQSPGEKPAAAAKSPTIRALVLDKDNTLCPPKTTAFPPQIIDKLSALRNSPTSPFNQSTAPDSILIVSNRAGSHPRFDAEVREIEERLSPLRIPVFRLPEGSEKKPFCGREVLDWFRERGVVTRADEIAVVGDRLGTDVLMAAMMGSWSVWCRDGVYEGVDPLKGRPNMNILERMEIWIEKYLREFRGLKAPLPRGWESQQNLVCRPRQPTSCLCSISLAKKVPRGWRDNWRGISQATKRIHAEMMNNDESKSKEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6R3</accession>
    <name>B0Y6R3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_067860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000215_0_1_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6R3"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
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    </dbReference>
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        </location>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6S4</accession>
    <name>B0Y6S4_ASPFC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </reference>
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            <begin position="6"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP50459.1"/>
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    </evidence>
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        <source>
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</entry>
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    <accession>B0Y6Y8</accession>
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        <submittedName>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="767" mass="86670" checksum="F31D4322E7B9F933" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y763</accession>
    <name>B0Y763_ASPFC</name>
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        <recommendedName>
            <fullName evidence="5">Enolase</fullName>
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        <alternativeName>
            <fullName evidence="10">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_072700</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y763"/>
    <dbReference type="SMR" id="B0Y763"/>
    <dbReference type="Allergome" id="3116">
        <property type="allergen name" value="Asp f 22.0101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072700"/>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="PhylomeDB" id="B0Y763"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="15">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP49244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="438" mass="47305" checksum="821212CBDCBAEA2A" modified="2008-04-08" version="1">MPISKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEAHELRDGDKTQWGGKGVLKAVKNVNETIGPALIKENIDVKDQSKVDEFLNKLDGTANKSNLGANAILGVSLAVAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFQNVLNGGSHAGGRLAFQEFMIVPDSAPSFSEALRQGAEVYQKLKALAKKKYGQSAGNVGDEGGVAPDIQTAEEALDLITEAIEQAGYTGKIKIAMDVASSEFYKADVKKYDLDFKNPESDPSKWLTYEQLADLYKSLAAKYPIVSIEDPFAEDDWEAWSYFYKTSDFQIVGDDLTVTNPGRIKKAIELKSCNALLLKVNQIGTLTESIQAAKDSYADNWGVMVSHRSGETEDVTIADIAVGLRSGQIKTGAPCRSERLAKLNQILRIEEELGENAVYAGSKFRTAVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y765</accession>
    <name>B0Y765_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="17">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_072720</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="17"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y765"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072720"/>
    <dbReference type="HOGENOM" id="CLU_003818_3_0_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="PhylomeDB" id="B0Y765"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060205">
        <property type="term" value="C:cytoplasmic vesicle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000033">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP49246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="704" mass="79972" checksum="2180CF07B25FE7DA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y793</accession>
    <name>CBHA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable 1,4-beta-D-glucan cellobiohydrolase A</fullName>
            <ecNumber>3.2.1.91</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-glucancellobiohydrolase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiohydrolase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Exocellobiohydrolase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Exoglucanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cbhA</name>
        <name type="synonym">celD</name>
        <name type="ORF">AFUB_073010</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y793"/>
    <dbReference type="SMR" id="B0Y793"/>
    <dbReference type="GlyCosmos" id="B0Y793">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP49274">
        <property type="protein sequence ID" value="EDP49274"/>
        <property type="gene ID" value="AFUB_073010"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073010"/>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="PhylomeDB" id="B0Y793"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF6">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393539" description="Probable 1,4-beta-D-glucan cellobiohydrolase A">
        <location>
            <begin position="18"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="452" mass="48135" checksum="B62A9D4115A45295" modified="2008-04-08" version="1" precursor="true">MHQRALLFSALAVAANAQQVGTQTPETHPPLTWQKCTAAGSCSQQSGSVVIDANWRWLHSTKDTTNCYTGNTWNTELCPDNESCAQNCALDGADYAGTYGVTTSGSELKLSFVTGANVGSRLYLMQDDETYQHFNLLNHEFTFDVDVSNLPCGLNGALYFVAMDADGGMSKYPSNKAGAKYGTGYCDSQCPRDLKFINGMANVEGWEPSSSDKNAGVGGHGSCCPEMDIWEANSISTAVTPHPCDDVSQTMCSGDACGGTYSESRYAGTCDPDGCDFNPFRMGNESFYGPGKIVDTKSKMTVVTQFITADGTDSGALSEIKRLYVQNGKVIANSVSNVAGVSGNSITSDFCTAQKKAFGDEDIFAKHGGLSGMGKALSEMVLIMSIWDDHHSSMMWLDSTYPTDADPSKPGVARGTCEHGAGDPENVESQHPDASVTFSNIKFGPIGSTYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7C5</accession>
    <name>B0Y7C5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS8m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_073330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7C5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073330"/>
    <dbReference type="HOGENOM" id="CLU_107213_0_0_1"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7C5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="170" mass="18646" checksum="B8FCF8F27DA988A3" modified="2008-04-08" version="1">MSLVNLAHVCSHLNNASKARLGLTSIPHSNLHLKLCLALQNSGYLSSVVRGGPTPPPPHILLGHPAPNDEVEGIEPLTQANIASRRLWLGLKYWQSEPVLGKMSMVSKPTRRITIDVAGLRRVIRGEKSDYVEGLRTPGESLYLSTDRGILESRECVEKKIGGLVLCRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7J1</accession>
    <name>B0Y7J1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_073990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073990"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7J1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF7">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="563" mass="62132" checksum="1C3E30333C6FAB60" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7M7</accession>
    <name>B0Y7M7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_074350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_074350"/>
    <dbReference type="HOGENOM" id="CLU_040908_4_0_1"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7M7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000271">
        <property type="entry name" value="Alkali-sensitive linkage protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="132"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="363" mass="39266" checksum="145485C2520CF13A" modified="2008-04-08" version="1">MVHSPWSALRWEDRQADIMLATPRHSLLPQWLLSDVEPDCQRVSSDGRSNDNPVASVSPDGDPFTANTGPEERTNEGHHPASTMGNRQKRRRLKMVSFKNMLTAGLLASSAVAAPHGHQHRHIEKRSSTKRGAAYNDASAVQALGSNGSISWAYDWNMLASGTLPSGVEFVPMLWGSKMFGGWASAIEAALASGSQYILGFNEPDNSAQSAMSPSEAAQAYQQYITPYSGKAKLVSPGVTNSGSPGEGLDWMNTFLQSCTDCGISALAVHWYGNSAEEFKTFVNKAISFASEKGLESVWITEFALSNDINTGASSSESEQFLTEVLPWLDSQPMVARYAYFMCANNYLLSGSGLTSTGHVYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y897</accession>
    <name>B0Y897_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit sconC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongin-C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_076580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y897"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076580"/>
    <dbReference type="HOGENOM" id="CLU_130038_1_0_1"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="PhylomeDB" id="B0Y897"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="10">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="104" mass="11429" checksum="DE5E99C896D633C2" modified="2008-04-08" version="1">MASSSSTSSEYVTLVSGDGFEFIIPRSAACVSGTIRRMLEPSSKFSEAITGRCVLENLSGVVLEKVCEYFCYNEKNKNQTNVPDMDIPPELCLELLMAADYLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y941</accession>
    <name>B0Y941_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_079560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y941"/>
    <dbReference type="HOGENOM" id="CLU_009941_1_0_1"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="PhylomeDB" id="B0Y941"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="832" mass="92710" checksum="93E5B42B3634F1F6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9S1</accession>
    <name>B0Y9S1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCCH zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_082070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EDP48764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_048898_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="388"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP48764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="452" mass="49998" checksum="A5F615663760EB5A" modified="2008-04-08" version="1">MTEDQELMAKISQLAGQINRHKNQTPQAQAPTYQGSELHAGPYVSRHTRARGGWAPYRGRPYGRGRSAAPHRHRTLVLNNVNSGNSTSSTPVPTNENAGESRSATPNGWVAKRDRHMQLINSAIYDKEAQARAKAMEQTRKAKAEKKARIEQAKVLRYAQGFGRPHLATTAASQVSATTQPHGEYQVYLNDIPFKIAKGGSKLVRVSDDPNTANITPKKVTVAGVTFVRSKNGNLHRLGAVTSKRKPTAVKKRNELCKRFTSTGACYKGPSCLFIHDPNKVAICKEFLQTGNCSAGQNCDLSHEPSPHRSPVCVHFLRNRCSNPDCRYSHVRVTPGAPVCRDFANLGYCDKGAECEQRHVHECPDYAASGVCNKKRCRLPHVDRAGQIRKNAASKADAADEEESDESSEDEEYDAIDSDDVDSDDLDDEPEYVEGADNGEQELFQQHDFIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA47</accession>
    <name>B0YA47_ASPFC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_083390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    <dbReference type="PANTHER" id="PTHR36854">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="87" mass="10001" checksum="ED19E88E93C3B58A" modified="2008-04-08" version="1">MCKGAKEDDVFTTCFRMAVSIAWSSNLDTGYSIYKRDSRKDEAIVFIFIIATSGLLTWAACKPWVEKWLEAARERRSYIPVSENAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAQ3</accession>
    <name>B0YAQ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_085450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085450"/>
    <dbReference type="HOGENOM" id="CLU_017443_2_0_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="PhylomeDB" id="B0YAQ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF9">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="251"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="720" mass="80485" checksum="0E813911F371D88A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAS5</accession>
    <name>B0YAS5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_085670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085670"/>
    <dbReference type="HOGENOM" id="CLU_051938_0_2_1"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="PhylomeDB" id="B0YAS5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000375">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF1">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="239" mass="26686" checksum="E102493057D97FFE" modified="2008-04-08" version="1">MTINSLPRIACFHGGGSSAAIYRIQCEQLAHLLKNDFQLVFFEGPFERSAGPDVLPVFADYAPFKSWFTQDERGERADGSGYDASGNDGVERVWRLMEDEGPGGEWVGAMGFSQGSRVAGGLLLDQQRRDALGIPKKTPIKLLFGVLCNGAGAPMESDVAEYIEKPDESLRRVSLPTLHVHGLKDPFLMLGRQQFQDYYNPNAATLYEVDYHHAMPWARHEAKQLADHIRTIYKNNAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAZ3</accession>
    <name>B0YAZ3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-hydroxytryprostatin B O-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.293</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Fumitremorgin biosynthesis protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_086340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-hydroxytryprostatin B + S-adenosyl-L-methionine = tryprostatin A + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37903"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:72761"/>
            <dbReference type="ChEBI" id="CHEBI:72762"/>
            <dbReference type="EC" id="2.1.1.293"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.293" evidence="8"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086340"/>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="PhylomeDB" id="B0YAZ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000646">
        <property type="entry name" value="6-hydroxytryprostatin B O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="11">
        <location>
            <begin position="199"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP49186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="411" mass="45569" checksum="4940843C00A1BD62" modified="2008-04-08" version="1">MSDLPEVATRLSKNVEILVDEIDKTGSQPGCGKPTALGAKGLAARDEIILAAEKLLQQGRGPGPSLLSLLESAVDIGTIQTLIRLEVPDQVPLTGSIPYDALVKKLKTPVDPELLQRLIRFTRLVGFLDEDAEGAVKHSPMSAIFVNDPDTAGQARFMADFGIRPCSFIYESIKLDPSGEAARQGPLALMAREPGAREGPTFFEVLEKDPVNRKRWHDGMAVHNDSMVRHVAGAYDWGTVQSLVDIGGSEGHVAAVIVNAFPHIQITVQDRPEIIEKARQRGDRHPNIIFEEHDFFTPQPRIADAYFLRLILHDWNDADCTRIVRQISSALRPGARLLIMDAVLPEPGEGSLQSERRLRRSDIGMYTLFSAKERSLAQMRRLVEDCDSRLRFEKLYTPPGSHASMLSWICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCX6</accession>
    <name>B0YCX6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hsp70 nucleotide exchange factor FES1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hsp70 nucleotide exchange factor fes1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_093540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCX6"/>
    <dbReference type="SMR" id="B0YCX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093540"/>
    <dbReference type="HOGENOM" id="CLU_084507_0_0_1"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="PhylomeDB" id="B0YCX6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="10">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP47510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="216" mass="23498" checksum="166BF37D2F49EC24" modified="2008-04-08" version="1">MDPNMNNLLKWSIENSTSARQAGNSNGTGPAPASRSNLNPEMLSALFGGPSDADLMKAAMEALHSDEVDLENKMIAFDNFEQLIESIDNANNLEPLGLWTPLVELLKHEEAEMRRMAAWCIGTAVQNNEKAQDKLIVFNVLPTLVAMSTSDPAPAARKKAVYAISSGVRNYQPAMDEFVKHLPEGYTSGEKIDAADMEAIDALLDKLRAHPSEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE77</accession>
    <name>B0YE77_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_098210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098210"/>
    <dbReference type="HOGENOM" id="CLU_2235982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="105" mass="11794" checksum="0956CB904C7DD4EE" modified="2008-04-08" version="1">MDNRFSTWIFHCPFRHRPDVAIHACLFQVRRVSSTSCLPGHLKADRHVAQCMRWISKDDHGVQCPLEEVQGRSAGVHPLSMTMAAATNIVLEAGLGLRRVLGRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEA4</accession>
    <name>B0YEA4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_098480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098480"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="PhylomeDB" id="B0YEA4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="297" mass="32907" checksum="2C8D91DE465779F3" modified="2008-04-08" version="1">MTTERDDRKSVLITGCSPGGIGNALAREFHRNGLRVFATARDAKNIDDLAALGIETLDLVVDDEESVKFCCSEVERRLGSKGLDFLVNNAGRNYTVPATEIDLAEARKTFETNFFAVISICQAFLPLLIKAKGTIVMIGSVAGIIPYVFGSVYNASKAALHSFSDTLRVELAPFGVNVTTVITGGVQSRIARTKRTLQPNSLFTPIKDEYARRVTHSQDGAMPHAAYARSVVTQVLYGSAPWRWLWPWAQGRKSWIWEGNKSWLIWLLCGGWAWTGLFHGAMTRMFKLYKLKNAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEA6</accession>
    <name>B0YEA6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_098500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098500"/>
    <dbReference type="HOGENOM" id="CLU_042063_0_0_1"/>
    <dbReference type="OrthoDB" id="5295250at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="500" mass="57368" checksum="3387275FA59C5E19" modified="2008-04-08" version="1">MEFVDPNSDEQEIITRLQNLRAKPARRRLFRQLVHQLASDEWRDLRDLLNKRTFKCDILGLLPPEIAVQVAQYLDLAEIHVLQRVSRTWHKLLSSNPVCSAVYRRYSGRTLDLFHQASRHIYNQYAKQRIRLERGEPSSALRRREPSHISPACLDYSNGRYAWTGEMTTVVVQDMCSHAMQMFCTENRERIGHIRLSDMIVAAVTLRGYCHVWNLQTEESAYFRLPSRLFHLFAVRGTKVAFGFKDPAAGNTVVMQWDFNSRVSRTVVVADHLVFIDLHPTLDCLISIHLQRNDGVDGPWDLEGVPCNATQLQVVKHYPDDSVGAPQTASKSIALPRLEDNDWVVRPNAWLSDQFNDRVGILIARPKGSKDHHPHYIIAITYYIETEEVFLHLLPPEHTFSSHLHLAPVDRNLLYYIRVEGAMPTIWISQPGAQVPYRPAKSMPSPWAVDPGQHDADEYVLKGDHDCVLLLNRGGVSAWCFDEAAQPLRAIPFQLPENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0YFA2</accession>
    <name>B0YFA2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_102090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YFA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_102090"/>
    <dbReference type="HOGENOM" id="CLU_1120017_0_0_1"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="PhylomeDB" id="B0YFA2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="45"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="293" mass="33124" checksum="DC44107C35324FE1" modified="2008-04-08" version="1">MVAVMNQLTDLPNWYIDIFDDAIVAYWRQNPDLASIVTNPLLSDRAWDWCLHELRDKAEEYQRQRHVRVLDTGSCICKSDAVPGLPNGTGALADEIRPAVKTVLQKWSKSGWLDWRSKQRLSIIDPMLFPLVYGRSLVLTDRGRVELEDVFGAYSVATTIAPMHVDLRTDAAAVQKRLEEAQRLHMGVSCDTETSTHYRWSANHQALSCEVEFVGDKGSTQVRITSYINNLHPAHQDIYCAIETLVGRAIPLWNDCLVQGQSGWTDVLNQGHLGPVPLRIITYGAEWENELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMB7</accession>
    <name>B0XMB7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_000510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000510"/>
    <dbReference type="HOGENOM" id="CLU_072366_1_2_1"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="PhylomeDB" id="B0XMB7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="190" mass="22025" checksum="21AA8EC6A6BA572F" modified="2008-04-08" version="1">MGKSQSKLSPSQLEELQRATHFDKKELQQWYKGFLKDCPSGTLTKEEFQKIYRQFFPFGDPSSFANYVFRVFDSDNSGMIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGKITYDEMLAIVEAIYKMVGSMVKLPEDEDTPEKRVRKIFRMMDKDENGSLDMEEFKEGSKRDETIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMF9</accession>
    <name>B0XMF9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrnA-like fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_000110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMF9"/>
    <dbReference type="HOGENOM" id="CLU_009353_1_0_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="PhylomeDB" id="B0XMF9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF15">
        <property type="entry name" value="PRNA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="335"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="735" mass="83049" checksum="C6F6E84FC82BE2A6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMK6</accession>
    <name>B0XMK6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_003080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003080"/>
    <dbReference type="HOGENOM" id="CLU_1133347_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="245" mass="27402" checksum="2511823A70907BAD" modified="2008-04-08" version="1">MYQFEAWCSSFGAGYFFLDNLEVPELRGLVSTTTDHRFAIGMDVQRPDWSIVRLDRIQQSRGCNVKNFQFAVLITDYNDLVTREKGRAQGIAAFQCTQTALRTNVPNLQAAVGGRSQHSVVGTQGNRSDVGTVTRDVNSQVAIVVGAIIILLFIRSGDAVRFQLVVRSRSQKLEVARSFCSNPVEGTDLAASANNDVRNKDFSDRRRRNIVDLLIINFCHRPFPLGFFLLSSLTLPGQALLYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMR0</accession>
    <name>B0XMR0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fasciclin domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_013850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013850"/>
    <dbReference type="HOGENOM" id="CLU_026522_0_1_1"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="PhylomeDB" id="B0XMR0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000042">
        <property type="entry name" value="Fasciclin domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000045">
        <property type="entry name" value="Fasciclin domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757679" evidence="1">
        <location>
            <begin position="20"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="128"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="286"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="499" mass="55255" checksum="5985412411527F85" modified="2008-04-08" version="1">MKLYCLWPVLSLCAAIVIPDEQVLSNIAKPDTNKNSVDKDSTSFLSSIESSVKDAANDFRNALDEALELASDAVTTQRLQSGAFEAASWITNSFDHPTDAEYLPQDLKQLPQYLHPRPPFPPHHPSFNKTIYELIKSSKYTTILAKIIDEDDELVQFLNSTDANHTFFAPTNEAFSKIPHHCPGRDHDHDGDDDHKHHKVPKEVIRAIFHYHVAPGRYSAADVFHSHTVPTTLNESALGHDLPQRLAVRVGWKGLTLNYYSHIVAADIGATNGIIHGINAILIPPPETLTLLTIVPSEFSTFTLGLYKTGLATALNKSSTPHHHGGTIFAPSNSAFKHLGLKINAFLFSPIGEKYLRALLQYHIVQNRTLYSDVFYTAQGEIKPFGVKGFTHLDLPTLLHGRKLAVDVARFGPFASLKINGFQRVAFADALAKDGTVHVVDRVLIPPRKVDDSAPDWTGNDDELTVEDLKSRLGDWLAEDEGVDEVEMMHDILAHGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMV7</accession>
    <name>B0XMV7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_003460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003460"/>
    <dbReference type="HOGENOM" id="CLU_045864_1_0_1"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="PhylomeDB" id="B0XMV7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099079">
        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904600">
        <property type="term" value="P:mating projection actin fusion focus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000005">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="285" mass="32143" checksum="2C2862DE77AAE514" modified="2008-04-08" version="1">MADIQFDSALDLLRRLNPRDTKQNLQAITSIVPDLTEDLLSSVDQPLEIRRCPKTNRDYLLCDYNRDGDSYRSPWSNEFDPPLEDGTVPSERVRKLEVAANEAFDVYRELYYEGGVGSVYFWDLDDGFAGVILLKKGVTPGAKSSGEWDSIHVFEATDRARMSHYKLTSTVILHLANENEALGEMDLSGNMTRQMEVDLPVESDASHVANVGRLVEDMELKMRNLLQEVYFGKAKDVVGELRSKPLLCHGRTKAMDADKNTGLAPLSETNKEKAAHLEMIRSMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN03</accession>
    <name>B0XN03_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_003920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003920"/>
    <dbReference type="HOGENOM" id="CLU_050669_4_1_1"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="PhylomeDB" id="B0XN03"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000019">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="297" mass="32376" checksum="35226F62EAE7DBCE" modified="2008-04-08" version="1">MFSRAVRPAVRAGSATLTRTAPPNAANFATLREIEGRLKSIKNIEKITNTMKIVASTRLTRAQKAMDDSRVYGQTSNKVFENAETKPLEDKKTLLVVASSDKGLCGGIHSGLSKATRRILQENPNADVVILGEKAKAQLSRSNADAIVMSFANVCKDIPTFADAQVIADQIAQLPTDYASVKIIYNKFINAQSYEPSTVEAYSEEAITKSANLATFEVEDSVLANLREYALANSLYWAMAEGHACEISARRNAMENASKNAGEMINKFQILYNRQRQAAITGELVEIITGATASEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN57</accession>
    <name>B0XN57_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SRm160/300 splicing coactivator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_014660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Egan A."/>
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                <person name="Fraser-Liggett C.M."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
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                <person name="Orvis J."/>
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    </evidence>
    <sequence length="309" mass="34833" checksum="A33CA374E7CBC437" modified="2008-04-08" version="1">MSLEYHYTNLAVYELAIGEGYRDPDAIKQEYYTLPRPEGDRRNQRASNPLSAIRVDITIKWMHTAHEMLNFFLSCDNELMRKLPNLAYTRVGVALMSLLKIYFTVISGGLGKFVTPESVKVEMYLDAIARRLTEASGGQKYKIPSRWYYVLAVKSRNWYDRLQQRQAQRESSFASQMEVGQSIQMQVPAHTLQHPCPVNPNCSTEPLVGDAGIPQRPPYSNMGGAYGAPVAMNHMWHVDQSHAPTSLSYQYPEYQPPILQSQYGYVAQHPSLPSESNQDQPPLHRSTGMELDGWLPDGSIIGAPTLPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNQ7</accession>
    <name>B0XNQ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General stress response phosphoprotein phosphatase Psr1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_005130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005130"/>
    <dbReference type="HOGENOM" id="CLU_020262_2_0_1"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="PhylomeDB" id="B0XNQ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="403"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="577" mass="62880" checksum="082EE3F5FAC7EE9A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP29</accession>
    <name>B0XP29_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mucin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_005720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005720"/>
    <dbReference type="HOGENOM" id="CLU_037235_0_0_1"/>
    <dbReference type="OrthoDB" id="5391991at2759"/>
    <dbReference type="PhylomeDB" id="B0XP29"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38251" checksum="3D6B87D06281CD4E" modified="2008-04-08" version="1">MAPQTATSTIAMALAGKTASVDIPKPRSGFSSGRRDSVRPGHPAMLPTPPNSISPTLPPQAFKKQDLRRPGSPPLATSPHVDSDIDLGDAATDQRQSAHGSDNVGEITPSMLARYHLPEIMLNQGPLAIRHVMAYLTTSVPGFSRIPPAKARRLVVAALEGRGSEGGGLSSDVIFEKVXXXXXXXXXXXAVANPAQPLAPNRVATRQFLELVYSTGMTGDSTVFSYTEREHGHGDLSMLEHEADKMSLDGDDREYCSSSEAPDEEIPDEDWGEEDITDEEDWAQIGAAALRARSLNGGGFMNGSGPSPLLRGGGPAPSSLAKSAPRQIPIQQFGFSVPDGMVDNKEERAAVEALLRLGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPI2</accession>
    <name>B0XPI2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone H4 arginine methyltransferase RmtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_006570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPI2"/>
    <dbReference type="SMR" id="B0XPI2"/>
    <dbReference type="HOGENOM" id="CLU_017375_1_2_1"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="PhylomeDB" id="B0XPI2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060567">
        <property type="term" value="P:negative regulation of termination of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="72"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="40181" checksum="1BD1DF4DC0211649" modified="2008-04-08" version="1">MEGVQRQQSAEPSAMIPSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVIGVDMSSIIEKAREIVAVNGLSDKITLLQGKMEEVQLPFPTVDIIISEWMGYFLLYESMLDTVLYARDRYLAPGGKIFPDKATMYLAAIEDGEYKDDKIGFWDNVYGFDYSPMKEIALTEPLVDTVELKALVTDPCSIITFDLYTVTKADLSFKVPFSLPVKRSDFIHAIIAWFDIDFTACHKPISFSTGPHAKYTHWKQTVFYLRDVLTVEEEECVSGILENKPNDKNPRDLDIQISYKLETTDKLRYDEGSCFYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPP1</accession>
    <name>B0XPP1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">VHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_007070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007070"/>
    <dbReference type="HOGENOM" id="CLU_017092_0_0_1"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="PhylomeDB" id="B0XPP1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1230:FF:000010">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="188"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="522"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="642" mass="70135" checksum="A7E4E2D09CA3DE0C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPY8</accession>
    <name>B0XPY8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_008030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP56102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008030"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="580"/>
        </location>
    </feature>
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        <location>
            <begin position="571"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP56102.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="580" mass="63649" checksum="F7297029B35FA5AF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ14</accession>
    <name>B0XQ14_ASPFC</name>
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        <submittedName>
            <fullName evidence="4">IQ calmodulin-binding motif domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">AFUB_008340</name>
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    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008340"/>
    <dbReference type="HOGENOM" id="CLU_005050_0_0_1"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ14"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="985" mass="109891" checksum="0D5A4278B9102B03" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ83</accession>
    <name>B0XQ83_ASPFC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">AFUB_009060</name>
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    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_022333_0_0_1"/>
    <dbReference type="OrthoDB" id="5408998at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="708" mass="78708" checksum="BEB422C080F20214" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQC6</accession>
    <name>B0XQC6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_009480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009480"/>
    <dbReference type="HOGENOM" id="CLU_133420_0_0_1"/>
    <dbReference type="OrthoDB" id="5415072at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="153" mass="16004" checksum="943D47A6E7BA2CD0" modified="2008-04-08" version="1">MGNLCSTSKNEAEPFSRPGRVLGSAANPPPNAAPRAPLPAKSKAPFKSPGRSLGEAAPEVPGAERADARTNAAIAAQVSDTVERSGAALVCGRWLTGECQKRAESAAKAQKGKLGSKLAAQKAQTQAKTLSEVSREQISARHMDESSEARRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQK8</accession>
    <name>B0XQK8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Purine-cytosine permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_010310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010310"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="PhylomeDB" id="B0XQK8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF16">
        <property type="entry name" value="PURINE-CYTOSINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="505" mass="55173" checksum="0D4B95B8EF91578C" modified="2008-04-08" version="1">MVSEFEKHRQSPSLHSVTQIELGDCGSSSTVCQSRYQRWTRSFKTLETRGIEPVSPDDRQKPTTSDLFHMLLIWFSMGMAVNHMVVGSIGTLVMNLNFTDAALCAVFGNLIGGLAVGYMSTWGPRSGNRTLVMTRYFMGYYPNKVCCSLNVLTNLGYGMINAMVGGQILSKLSGGTVSVIVGIIIVALGSAIMATFGMRVFHIYERFAWLPQLLTFCILAGSAIPQFDLHAKSVGSSDEINAKRLGFFSLCMSSALSWAPSAADYYVYYPSTIRPWKVWSVTTIGGCGAMIMSILLGVGLGTGVASNIRWQALYDGTPGSLLMAGYDRLGAFGKICGFINVLTVVSNNGPGTYSLAMNFQMLGDIWSRVPRPIFTIASTVTYTACAIGGRDFLYQIFKNFLPLIGYWIIIWFTIAVEEDVLFNRCRGYDWSIWNDWRKLPVGVAAGVSFLIGWAGAIVGMDQVYYTGPVANATTGGCDLGIWLGLGFTAISFPALRLLELQMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQM4</accession>
    <name>B0XQM4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_010470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010470"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="PhylomeDB" id="B0XQM4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="58632" checksum="28A7696716E960D8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQS2</accession>
    <name>B0XQS2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_010960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQS2"/>
    <dbReference type="HOGENOM" id="CLU_059964_3_0_1"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="PhylomeDB" id="B0XQS2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000039">
        <property type="entry name" value="2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="281" mass="29793" checksum="6230B86F03D2C3C2" modified="2008-04-08" version="1">MQAMQAANRLQRALRTERGLSFGAWQMLPGANHARFMARTGYDWICVDTEHGNIAVMAMADGGFAADWQMHEAVAAIAATGVSPIVRIAANEGWMVKRALDAGAHGIVVPLLYTADDARRLVESAKFPPVGRRGFGSPFAMGSIGGVSGLEYLQGANDALLTIVQIETKEALENVEEIAKVPGIDVLFVGPWDLGNNIGRPVTGAFHEDLEAAIERIRKAAVDNGKRAGIYCVGGAAAKKYADRGFHMISVVADAVALPTFLADALETAKGSKTDAAVPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQV6</accession>
    <name>B0XQV6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import receptor subunit tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_011310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011310"/>
    <dbReference type="HOGENOM" id="CLU_094333_1_0_1"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="PhylomeDB" id="B0XQV6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="143" mass="16119" checksum="489DF2E39033098D" modified="2008-04-08" version="1">MVKLTEVEDEHFAQEKPMATKNNVLLATDDEDEDYTDTESEISVESDLDVEGETLYERVAALKDIVPPSTRRQISSTVSTLTSFTKSSISFSGKALWILSTSAFLLGVPWALAYAEEEQYVQMEREQGMIKGANEVCLRMFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRD8</accession>
    <name>B0XRD8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">AFUB_002120</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRD8"/>
    <dbReference type="HOGENOM" id="CLU_004875_2_0_1"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="PhylomeDB" id="B0XRD8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000443">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757803" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="28"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="711"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="24">
        <location>
            <begin position="1029"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="547"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP55517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1165" mass="130051" checksum="ECB0B02CBC88AFC0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRE7</accession>
    <name>B0XRE7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_002210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002210"/>
    <dbReference type="HOGENOM" id="CLU_113836_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0XRE7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18296" checksum="18B1425201272F7B" modified="2008-04-08" version="1">MSHPTDEKTFVDQVPRESDAEKGSVSHEFAPKSKLDLFEDPDEGLSPEERAKIDRALVRKLDIRLIPWLSLLYLISFLDRTNIGNAKLAGLQKDLNMTNDQYNDSLTIFFISYSVFEPITNVLLKRWRPSRFIPAIMFGWVDATCTCSKFELMESRAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRQ5</accession>
    <name>B0XRQ5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_013510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRQ5"/>
    <dbReference type="SMR" id="B0XRQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013510"/>
    <dbReference type="HOGENOM" id="CLU_066040_1_0_1"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="PhylomeDB" id="B0XRQ5"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="285" mass="31490" checksum="3B39977F72174678" modified="2008-04-08" version="1">MLYLVGLGLADETDITVKGLEVVKRAERVYLEAYTSILLVSKEKLEAFYGRPVIEADRELVETGSDEILAGADKADVAFLVVGDPFGATTHTDLVLRAREMGIESKVIPNASIMSGIGCTGLQLYNFGQTVSMVFFTENWKPTSYYDRVKENVQLGLHTLVLLDIKVKEQSYENMARGRRIFEPPRYMTVAQCASQMLETEEERKEGVFGPDSLAVGAARVGGPDQKLVVGTLKELSEVDMGPPLHSLVLLGRKAHDLERLYIREFAVDKATFDASWNKGYGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS07</accession>
    <name>B0XS07_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_025500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS07"/>
    <dbReference type="HOGENOM" id="CLU_008264_1_1_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B0XS07"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000629">
        <property type="entry name" value="RING finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760431" description="RING-type E3 ubiquitin transferase" evidence="15">
        <location>
            <begin position="37"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="382"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="298"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="431"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP54493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="544" mass="59060" checksum="6F014F01FF60993A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSK0</accession>
    <name>B0XSK0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CobW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_027470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027470"/>
    <dbReference type="HOGENOM" id="CLU_017452_0_1_1"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="PhylomeDB" id="B0XSK0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="46"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="402" mass="43624" checksum="8AF28F2AC9262ADB" modified="2008-04-08" version="1">MPADIIEDDDAPPELVDVSALPDSEKLNISTTPSTTLDTPAQDRVPITLVTGYLGAGKTTLLNYILSEKHGKKIAVIMNATDIEKPLTVNQNGQEVTEWMEVGNGCICCSVKDSGVMAIESLMERRGTFDYILLETTGLADPGNLAPVFWVDDNLGSSIYLDGIVTLVDAKNILRLLDEPAPEETATSHTDGSENAGPGHSGPVLSMAHMQISHADVIILNKADLVTQEELDQVRSRILAINSVAKIHVTDHSRTPQIEGVVLDLHAYDHLDSLDFGAKGHSHIDPAISTIAIVIPPIPADKVSRVDTWLQSVLWESKIPVMDNIDTSNLNNFEIHRLKGILALQDGSCKIIQAVREVFEIRDSEPTTRGGGDCKLVLIGRGLGQDAQPWRRNFEAFLEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT33</accession>
    <name>B0XT33_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_017850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017850"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B0XT33"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="442" mass="50007" checksum="05D9F21CD6BE5A64" modified="2008-04-08" version="1">MPPRRILIVGAGIAGIASALAISKELTPYVPDLKITVFERHDVLSTSGGAINLTPVAQRHLDQLGVLAELDRLGDEGGADVDAIQFFSCRSGKSLGSIDFTRDQGQGFSGYKARRVMRIILSVAMLAVVERTRNIEIVFGKKLARGEETADEAILYFQDGTTAVGDLVLGCDGVHSATRTRWIAPDYPSEYTGISFLQGVVDAKTLKSRIHFRSTSMNISRHGTLLASYCDRDQEQIFLAAIVQFAEELLPRYRIEAGQDWRKQHAIRKALQEEMQDRFGKSGIPCIREMINSPTDWMLYPVYQVRPGGRWHTQRAILLGDAAHAMPPRDESAAYALDDAIVFARILARYRGEPLTDAFRAYEDIRREIVNEAFKSARRMWEKHKDMGLLESRLREWTLPFYIRNSKEAREAMWEFDATKISIPTPLEEQESLYSFEKDYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT53</accession>
    <name>B0XT53_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_018060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018060"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="PhylomeDB" id="B0XT53"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="355" mass="38599" checksum="6AB6C4A271C943E0" modified="2008-04-08" version="1">MAPSVKQWKSNLKGLDSLQQAEAPMPAPGQGEVLVEIHAVSLNYRDTEVVMGEYTHHKATQGVETIVVPCSDMSGVVIQVGEGVTAWKAGDRVLSTFLPDHQTGQVTEKELARGLGLPLDGVLATHRVFPEYALVRAPSYMTHEEASTLPIASVTAWMSINGMRPMGQNGGEGQYVLLLGTGGVSIAGLQIAKASGAKVIITSSSDEKLEQAKKLGADYTINYRTNPNWNEEVMRVTNNHGADIILETGGSETLSKTFDCVAFGGLIDCIGYTSGKQQNPNDTLNMNVLTLRKNLTIKGIINGPKDRFEEMVQFYEKHQIHPVVNRIFPFEESKEAFKFLASGAHFGKVVIKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUH4</accession>
    <name>B0XUH4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_030900</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030900"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0XUH4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="25"/>
        </location>
    </feature>
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        <location>
            <position position="462"/>
        </location>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP55029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="519" mass="58486" checksum="90C9DEED54FD09DA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUZ2</accession>
    <name>B0XUZ2_ASPFC</name>
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        <submittedName>
            <fullName evidence="3">Microtubule associated protein (Ase1), putative</fullName>
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        <name evidence="3" type="ORF">AFUB_031940</name>
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        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitotic spindle midzone"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
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            <end position="416"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV81</accession>
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        <recommendedName>
            <fullName evidence="4">DUF1760-domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">AFUB_032190</name>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
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                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
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        <property type="project" value="InterPro"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVA5</accession>
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        <alternativeName>
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    </protein>
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    <organism evidence="12 13">
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
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                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
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                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
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                <person name="Fraser-Liggett C.M."/>
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                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032430"/>
    <dbReference type="HOGENOM" id="CLU_054086_0_1_1"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="PhylomeDB" id="B0XVA5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001600">
        <property type="entry name" value="Pre-rRNA-processing protein esf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="419" mass="47642" checksum="FA006B39E488DC09" modified="2008-04-08" version="1">MLIDWLHNKIVHRPVGGTKKSCMKFLKPRSDQDNTTKKLRYRNFISAHLRQTADRDIEMTTRKRNEFLDVVSDDDEGSDRAYDSEAAEESKGRLAKRRKTHTRADDLSDEESDIGRSESEDESKTRLKGKPKSKSQTTERSNDDDDEDEADDGEKMQVDQYLDATATLSPSQSRSQSPSTSSVTSKPTKLKKKPLDKVRPPKKNKTGVIYLSSLPPYLKPFALKSMLETRGFGPITKVFLTPEVPSNSAPRRRSNKRKSYADGWVEFASKKTAKICAETLNATIVGGKKGGWYHDDVWNMKYLKGFKWADLMEQVQRERSEREAKRRIEDTRARKEDKVFLQGVEQGKVLQGIQKKNEEKKKKKGETGTGEGSADAAANASELKVRRLFKQNEVKMGRDKVKDISALEDDAKRVLSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVH2</accession>
    <name>B0XVH2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_022240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022240"/>
    <dbReference type="HOGENOM" id="CLU_007149_0_0_1"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="PhylomeDB" id="B0XVH2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000409">
        <property type="entry name" value="Anaphase-promoting complex subunit ApcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000033">
        <property type="entry name" value="Anaphase-promoting complex subunit ApcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000013">
        <property type="entry name" value="Anaphase-promoting complex subunit ApcB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="516"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="894" mass="100348" checksum="34AF9155820EAA43" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVH8</accession>
    <name>B0XVH8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_022300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022300"/>
    <dbReference type="HOGENOM" id="CLU_044234_0_0_1"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="40753" checksum="93ACCF1D0A59BA73" modified="2008-04-08" version="1">MGKHLHVDNARSIARYCPRFKNLIVWEWMEFTISSARFVDDDSDSETEEEETSAGDFLMALRRNTLERFEISRDSHFKPSMVQGLVAHSQSMRVLKLPKFRSELVVELLKSNPLQSLEAVHFFLGYEKRAEIAQPFGQWLGACQNLRRIETWLYHDELLMLANALQHPIPSLEVLIVQQNYEDDPRIIDAFYRGVSRQRNLQELTLNTEMTSNKSVFMWCLFHLKKLRKLNLRRVSSQLTLPDIGTLTSNFPDLTWLGLCVTPVVDEIWDYIVAPKLRYLHLVGIGVLHAQPVLDFIHRLGEQNRGFTLKLKFSTFAELYTTVSDEDHRAIAYALFSHLDGRLLPYREML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVV2</accession>
    <name>B0XVV2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_022870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022870"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="PhylomeDB" id="B0XVV2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="517" mass="58106" checksum="4D40B4356CA144EB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW61</accession>
    <name>B0XW61_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_023690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023690"/>
    <dbReference type="HOGENOM" id="CLU_717832_0_0_1"/>
    <dbReference type="OrthoDB" id="4498011at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="397" mass="46516" checksum="E34C7FDAC33489ED" modified="2008-04-08" version="1">MCLIEKYTDVYPVEIRTRTVIRRCLFSDGRGTCDRARVYDRGEFYHVRQSQQGGPRRMTSPRIKTIVPRNLSETRCQEEHRHPSPTWRLSQARSRSYSFRIPISRRSSETSDRETLCERRGRQRSPHPIVVDSPEVEERTPRNDRPDSVRIRCISPQAGRAPTTTDREQANDVVEIPRQARSQQPSREQRPPRERTPVTEREPVQRRPRRSLNCVVDIHNDAAASQDRQRQSAEPRQVRFSSDVEYEMNVNSTRARNRSAAFHQEESIDARAPTHRAYSRSNGSARDADSRSNGASHSRDSSPYPRVHSPNPGRVRQRHQETNRYRPRIIQDGTRIISEAGEHILAEGRERHRLVNSMRDVELRTHRRASNGRSGRLRFFRSGEENKDDRRHNNRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWE6</accession>
    <name>B0XWE6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_035620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035620"/>
    <dbReference type="HOGENOM" id="CLU_038125_0_1_1"/>
    <dbReference type="OrthoDB" id="5280547at2759"/>
    <dbReference type="PhylomeDB" id="B0XWE6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="339" mass="36403" checksum="79F511019D9F0B0F" modified="2008-04-08" version="1">MANTVFIPMHYKWLRHEEPSQHNILHFFANWELCNVASAMAMGVLTDNQTVWDFAVEYFKEGEGTGSIHNAITDIVEEPGTGAPLGQGQEAGRDQGHSALDVQLLAVVGQQAWNQGEDLFALNDSRILRGAEYWARYNLGHDDPFVPYSNGIVSFTELSSASRGAMRPTWELLYNHYVTIKGMDAPWTTKFLNESLNYYGGAEGGAGSWGEGSGHYDGLGWGSLLHRLDREDVAAQGSGANTLIASPNDKATSKLPQSTPDASRAGSSGANSTSMSTSVASSTPTPLSSPSSPLPGTSTPASTPDSQPTPCPPEAGQKPSHRAHRHSHHGRKHGRCHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWI5</accession>
    <name>B0XWI5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_036040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036040"/>
    <dbReference type="HOGENOM" id="CLU_017164_0_0_1"/>
    <dbReference type="OrthoDB" id="5407894at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="616" mass="67505" checksum="F9B4D29331CF9FAC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWY4</accession>
    <name>B0XWY4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase/serine esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_036840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036840"/>
    <dbReference type="HOGENOM" id="CLU_027968_1_1_1"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="PhylomeDB" id="B0XWY4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="449" mass="50019" checksum="188C718AB1F1D525" modified="2008-04-08" version="1">MSQKVDHLCVLVHGLWGNPSHLDYLTASLRERYGEDRLYILAAKGNSGNFTYDGIELGGERLAHEIEDTLGALDAEGTHIKKLSVIGYSLGGLVARYALGLLHARGWFDKLEPVNFTTFVSPHVGVRMPLKGIRDHIFNGLGARTLSMSGRQMFMVDEFRDTGRPLLSILADPDSIFMKALAKFRNRSVYANIVNDRSTAFFTTALSTTNPFQDLENVNVNYVKGYEPVVIDPDDYFLPPKKQEPPSFFSRLWQNIKGTLTQVAISLLVVVFVPIGVVLYLVNAAVQTYRSHRRIRLHEDGKAGVLISNYRVPVIVKDMQSAVEDAFESATAMQDPAYLSNARTRAGKKESLPQTPAVSKTGALENQTCTLDETSSALPDQKRDATLALTPAQFSIIESLNSVGFRKYPVWIHNHSHSHAAIIVRMAKKGFEEGKVVVKHWLDNEFDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX35</accession>
    <name>B0XX35_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_047580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047580"/>
    <dbReference type="HOGENOM" id="CLU_031144_0_0_1"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758438" evidence="3">
        <location>
            <begin position="19"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="77"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="415" mass="45702" checksum="758319A91B708E79" modified="2008-04-08" version="1">MKFLQMSCLSLLVSLSSSLSLPDGHGRHDIIPKTVVIDGTRLVENKLRLRAGDASLTAALGHLTAEADRWLSQGPWSVTAKTQAPPNGTIHDYASQAPYWWPSNTTDGCPYVNRDGERNPEVEKYPDHSGRDSMFRSSYILSLAWYYTGQAKYAQRASLILQTWFIDPATAMTPNLRHAQIIPCRNDGRSIGIIDFSMEYSNVLDAAVILASTNAPGWTRANQRAFMNWNRQFLDWLVNSPFGKEEASQENNHGTFANMQIAALALFTGNTSLSRKTSQGAKSLIDLQIRPNGSQPMELARTRSWHYSNFNLGAHLRFALVAKKVGVDLFGYKGPDGQSLFGATNFLLKAAVEGKSAWEFEELEFKPYAATDNVHAAADAGDSRAKAAVPRLPPPPTGDIYLLRPAAEQLDNIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXA3</accession>
    <name>B0XXA3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA exonuclease Rex2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_037360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037360"/>
    <dbReference type="HOGENOM" id="CLU_064761_3_1_1"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="PhylomeDB" id="B0XXA3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="69"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="250" mass="28805" checksum="72BF54DC3AD35BDA" modified="2008-04-08" version="1">MGVCYRIMNTQDNITLDFDTAFLSTMWKLLPLRVWQSNHLFLNPNHQIAIRSRSTASNYRMPLERSTDPLVWIDCEMTGLNPETDTILQICCYITDANLNLLDPEGFETIIHHDRSVLDSMSPWCVDTHGRTGLTAAVLASTTNSTTAAESLLAYIQRYVPHPRTALLAGNSVHADKMFLAKEPYKAVLEWLHYRILDVSAFKEAARRWGGETLLREVPPKKEVHLAREDILESIEEMRFYKERLFREYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXC7</accession>
    <name>B0XXC7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_037600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037600"/>
    <dbReference type="HOGENOM" id="CLU_016543_0_0_1"/>
    <dbReference type="OrthoDB" id="3439035at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="855" mass="96882" checksum="E33C4B8350DA9E0C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXI5</accession>
    <name>B0XXI5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_048450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048450"/>
    <dbReference type="HOGENOM" id="CLU_005513_0_1_1"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="PhylomeDB" id="B0XXI5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="322" mass="36556" checksum="485540ECB3444BA6" modified="2008-04-08" version="1">MNNEQLGYDPSIISMSDGRRFIEIIRDGHSERLILDRLMKRAPCIAGRATTCWIAHREGDKSHAPLVIKDPWQYPEREEEGKLLAEPTEKGVVNVARYYYHETVQVGGNLDDIRGNVRKGLDVTQATNYRPTRFQSSSVANAIVDTGRICRSTSRTGCKRSSSRAGEHGRALQNRVHRRVIIRDYGSPVYRAKSCISLLSALENCIKGYESLHTKVGFLQGDISTGNLILNDDEANPSWSAFLIDLDLAIKEQRERPSGARGKTGTKAFMAIGLLLGEKHSFMYGLESFFWIIFWICIHYNGPDESRIVPRFEKWNYVDWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYD4</accession>
    <name>B0XYD4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine-rich RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_040520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040520"/>
    <dbReference type="HOGENOM" id="CLU_012062_28_1_1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="PhylomeDB" id="B0XYD4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000684">
        <property type="entry name" value="Putative glycine-rich RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="118" mass="12810" checksum="8BE43731B4434283" modified="2008-04-08" version="1">MSKLFIGGLAWHTTDDALRQGFEPYGVVEEAIVVKDRDTNRSRGFGFVRFSSDTEADAAMDAMNNQEFDGRTIRVDKASERPARNNGGFHGRGGYNQSEGAPGNGGQRYGGNRGYGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYH3</accession>
    <name>B0XYH3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_040920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040920"/>
    <dbReference type="HOGENOM" id="CLU_081048_0_0_1"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP52919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="257" mass="26359" checksum="FD07A353B42091CF" modified="2008-04-08" version="1">MADTVPAQAPAATGRPTGAATATAPATAGASGTTTGTQPSGTNNPTTGNANANTSTTTTDSDSGNRGLPYYEKLRRDLRDALQKKRLMDKSMAQLEDQIYRFEQSYLEETTAGNIIKGFDNYIKGSGSSTGLGASGIALAGGMGGAARRKSQVTDADRVFSRSSASFMRDSPAPSSVQTTPSHAPTPTSTYNGSNGKPNGEGTSSAAASVKGSSSSSSKNKKKANGAGNKDKDKDDEGDEGGDKPPTKRLKITYGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ54</accession>
    <name>B0XZ54_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_043200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043200"/>
    <dbReference type="HOGENOM" id="CLU_018142_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
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    </dbReference>
    <dbReference type="InterPro" id="IPR044796">
        <property type="entry name" value="MLN51_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837:SF5">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="138"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="95"/>
            <end position="108"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP53150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="692" mass="74774" checksum="E4F6A2048898E212" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-05-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZH1</accession>
    <name>HRMB_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypoxia responsive morphology factor B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hrmB</name>
        <name type="ORF">AFUB_044390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2019" name="Nat. Microbiol." volume="4" first="2430" last="2441">
            <title>Fungal biofilm morphology impacts hypoxia fitness and disease progression.</title>
            <authorList>
                <person name="Kowalski C.H."/>
                <person name="Kerkaert J.D."/>
                <person name="Liu K.W."/>
                <person name="Bond M.C."/>
                <person name="Hartmann R."/>
                <person name="Nadell C.D."/>
                <person name="Stajich J.E."/>
                <person name="Cramer R.A."/>
            </authorList>
            <dbReference type="PubMed" id="31548684"/>
            <dbReference type="DOI" id="10.1038/s41564-019-0558-7"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probably modulates the generation of the hypoxia-typic morphotype (called H-MORPH) with altered biofilm architecture that leads to increased host inflammation, rapid disease progression, and mortality in a murine model of invasive aspergillosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal bipartite nuclear localization signalis required for nuclear localization and generation of the H-MORPH morphotype.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the hrmA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZH1"/>
    <dbReference type="SMR" id="B0XZH1"/>
    <dbReference type="EnsemblFungi" id="EDP53267">
        <property type="protein sequence ID" value="EDP53267"/>
        <property type="gene ID" value="AFUB_044390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044390"/>
    <dbReference type="HOGENOM" id="CLU_053540_0_0_1"/>
    <dbReference type="OrthoDB" id="4425826at2759"/>
    <dbReference type="PhylomeDB" id="B0XZH1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000460413" description="Hypoxia responsive morphology factor B">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA recognition motif (RRM)-like domain" evidence="2">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B0Y8Y7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q4WW97"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="31548684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="423" mass="48621" checksum="B016324CF621BE2B" modified="2008-04-08" version="1">MARSNYLRIFRVLEEINRRRTIPDIYHEALEDRLVITFTQPSGPLKRSKTRRPKKEYKLQYENTKAHRVYVEILEDYPQLFIPFILATPPKSCETFKLGEFREKHDLSAVKVDLRPDIRRTLDNIANRKGFNQNRRYRRLICTLFPSGRKPATTAETQNCWAYRAAYLNAVHTIFSEQICSAMEVSPTAHSPECQAPQTTSCVEMKLPKQNYQDAIVLLELSLPIDTIKILFPSANERIICSLSPQSGRGPEPSTQIAEPGRHDSQSEQSTISQSEGYILRGASISAILSVFGPRIWGAIEKSQLRKWEKDNLSEETTDCVSIEIHPRRPHCSTCRVRIGFIDDSHFRRKTVHLSLSLSAPNPLALLILEFNIFAVETVEPSFVVFRKYIIHWMFVAVIEEARRNSKGFPKGALQCCEYIHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZM4</accession>
    <name>B0XZM4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044550"/>
    <dbReference type="HOGENOM" id="CLU_1834716_0_0_1"/>
    <dbReference type="OrthoDB" id="5346621at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="140" mass="15274" checksum="51B66717795732C5" modified="2008-04-08" version="1">MASRAFSSTARQLKQLNWTLHGTTVDVSWLTQQIERSIDEVPGLRARVVSAQVIGNPHPTPNREDPYHGSVVLLDKDGKRVTSAHAYPNGYVKFSKEATFKPVKLPPMPGAPVIPPEGVATRKSDSTTLLSQSTSEKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZN2</accession>
    <name>B0XZN2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044640"/>
    <dbReference type="HOGENOM" id="CLU_041459_0_0_1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="492" mass="54702" checksum="FDED6DDFFA89FF58" modified="2008-04-08" version="1">MEVYKTRLSPHVLPSSPISTPLSILDATVARFAPAGAIWLWDRFSGNLPETDFIDCLQSLFVQTLSDYPQWAGQLQWAPVREGGNHTERFNRPMIVYGAPDDPADEWRVVKRDGISVGTLVPSAMERISAGAWDGANFPQRDFLSEPPLALHDLREYQGSPSMQVQITLLKSGAFAIGIRMAHVLADAQTLMVFVHQWAATSRATFGSHNSKSLMDAPVFNPALLGAHAAGDVDGPAPDRGLVATARELPLHRFDWWKTDDPGYPKVLVPNTLNSMPSCEQLDSVELSPSTSAPWTSWDLSRRIRYTQIHSSGNQLADLKRTALAQSQEDISRLDALLAHLWISINRARNLTNCPDSVFLDLSIGTRTRLSPPLPDTFLGSPLFLTHPLFTSEKIGAMLHDDAYEISPQRLWQAFLGSRHVLVTSWLRLKVYKIDFVGDGNRPRYVHAVLPKLDGEVQVMESGVDVNGVDVAVYLEEEVMERILAEQRQITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y033</accession>
    <name>B0Y033_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_045470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y033"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045470"/>
    <dbReference type="HOGENOM" id="CLU_012358_11_1_1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="PhylomeDB" id="B0Y033"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF37">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760597" evidence="5">
        <location>
            <begin position="25"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="87"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="512" mass="55421" checksum="B15D3582CE15E5B1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0N1</accession>
    <name>B0Y0N1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin biosynthesis protein (GliH), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_057900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0N1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057900"/>
    <dbReference type="HOGENOM" id="CLU_032731_1_1_1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="346" mass="38943" checksum="24EF1ABFDEBF6B11" modified="2008-04-08" version="1">MVNLIRNLEITLQNMKDAYTSREEVPFWATKLLTPTFMAVAILTTIPPPGPTRVIVGMTAFTSLWLYVLTHWMAGPAFFMDAIFMISITVRWMLMCLTGAPEIDYYQNSKTATKLDTMRLDTSEQGFGRDFPITTAGRILLNRYISDMVRKYAFCAFWPAQQASAATIDFGSLPMLHQHLLVAAQLIRDGLMLDSEYRKASLLCVGLYLSTPDRWPGLFGSPADLYTIFRHMFTRSGEVVASALGAEKGSLMYRYTKLYVGFLVSGVQHYACPLLIPSLRYGWGMFWQMPAYAAVITAEDLIKHYGKKAGIRDDRYVWTAYWMTLIYALPVGYVSDIGGFAGVCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0V9</accession>
    <name>B0Y0V9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_058710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0V9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058710"/>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0V9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="9">
        <location>
            <begin position="212"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="310" mass="34276" checksum="752930D41D34CAC1" modified="2008-04-08" version="1">MDTQPSLPIPISYISGSYYLFSIDAVTYLRREHHICGVLIGTLPQIPQQNVFLGLPLELMPEEARLLVEKGVACIVDEVNFQKDGMKSIMEADRQRYLQDIENQGLQAMQLQNSRKEQRREEVLKNLDEKKAAKAKRAATKQVSADGVQDMPGSEFFAGDDKQTDSTQTSRRASIAIQPQNAMGITPATSEDLLPSDLPATQLLPLPEVPSSYPLFAHLHAEGYYLSPGLRFGCQYLAYPGDPLRFHSHFLVVSAEWDEEIDLMDIIVGGRLGTGVKKGFLLGGAEEKDGDSSNEAGSNVRTFSIEWAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1F9</accession>
    <name>B0Y1F9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein TmpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_060190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1F9"/>
    <dbReference type="HOGENOM" id="CLU_005562_3_0_1"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1F9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075306">
        <property type="term" value="P:regulation of conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN TMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="493" mass="54433" checksum="D01B20E3D3AB3731" modified="2008-04-08" version="1">MSWSEKSEISIPPPAKCRSHSSHPSNVTLVDVEKEIAKILAEKNGSSKEVDLEAQGGARKKRHAFISSIRYTALDIYRRLFSLVFLANLAVFIAVMTADRKLLALVNATAANVLACGLARQPLVVNAIFVIVCSIPRSAPLRLRRVAAKVYHYGGVHSGCGIASFLWYAGFVGLMSKEYWSPAAGAGNAAFSILPVVLSYIILALLLAIILVAHPAFRMKKHDWFELTHRFSAWVVVVLFVILLLVFSGEASRAANQPLGTFLLHLPAFWFLVITVLAIIHPWLLLRKVSVVGETLSPHAVRLHMNHTSTTFGKGIQLATHPLQDWHGFATFPDPDGASFSCLVSRAGDWTSARIKCPPKHLWKRGVLIYGFAYAMRVFKRIIIVTTGSGIGPCLSFLGDENRPALRVVWQTRSPLRTYGRDVFNLVKKLDDDPVIIETNQSGRVDMLPIIRRLYTEFEAEAVCVISNPVVTKRVVFDLESGGIPAFGPIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1R3</accession>
    <name>B0Y1R3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell morphogenesis protein Las1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_060520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1R3"/>
    <dbReference type="HOGENOM" id="CLU_019519_0_0_1"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="376" mass="42420" checksum="E773A2214F4FC90E" modified="2008-04-08" version="1">MPALRYVIWTLRLNIMINGPKVAVWKLRGNLPHPVEATALLTDAILHDDAQKNSIFSIRATYSAAFCRFVTGLVDSKLHGQRKTMFQRAIDLGLPASFVELRHEATHRELPSLVVLRNATQRSLEWLWDYYWAKTDSDVALASGRPASAVSSGAENGNVEEIRSVIRTALEHPANQGDLSEPPRKKRKSDQQSSFLAEQLGAISKHIFTRLGDSMDEAFTKWDRSLQSVAAGHPAFLPALTEELVNELAFTRRPNTKNDPQCEAIYMWLDHILNSAEWSTARQSLSLGYILSVCEQNSNHWLDLLRGAIRSEDNRLPSIARDQSNAPSRSQKKSKSTTYDQPTEDNLQGLQKFGWERLDTWDNRPIGIIRLEHGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1Y6</accession>
    <name>B0Y1Y6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_050280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050280"/>
    <dbReference type="HOGENOM" id="CLU_002789_0_0_1"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000334">
        <property type="entry name" value="MATH and UCH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000024">
        <property type="entry name" value="MATH and UCH domain protein, putaitve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000295">
        <property type="entry name" value="MATH and UCH domain protein, putaitve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="135"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="374"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="834"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="936"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="938"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1261" mass="141584" checksum="D1B3709D4E44E80F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1Z2</accession>
    <name>B0Y1Z2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIG-P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_050340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1Z2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050340"/>
    <dbReference type="HOGENOM" id="CLU_038387_0_0_1"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="7">
        <location>
            <begin position="228"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="384" mass="42375" checksum="13AC403620C4114B" modified="2008-04-08" version="1">MSPPEIDDEKKPRSTDDSRGSARIVSSRESKQPFPPLPADEHATTMHDAPNNSYPGLDDSDMLSPTTDDLVEEEEDPDFHSSYSLDNQSFSDESMESDEEAAEDGIAMHHPFRQSSSSLHGPNAFAPPFYNRPPTPLPPSPSLTSLLRPPFSTTTSRPTTPDSSDVETPNDTEAAVAKSARRATTVPRASPKVPTYEYYGFVLYLASSLAFCESNPMRCRKRSPILILPTVIYILWSYLPSPFLHQLGIYYYPNRWWSLAIPAWLVMLIIYIYVALASYNTGYLTLPMNSIENIVDEVANVAVIDGKGRRRPGGAAKMKPGATSYQIMGPQNRKVNWKDIWSEGTDAVMDVPVGGVCEVLYGQERDDGELSDGHTGFAPGTAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2T1</accession>
    <name>B0Y2T1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_051870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051870"/>
    <dbReference type="HOGENOM" id="CLU_044882_0_0_1"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="498" mass="56985" checksum="1929828E9ED032F8" modified="2008-04-08" version="1">MAGEEEDINRTNNPPPFTERVHDHNPFVAFRRYADEQISSMLQAVMGLPSSISAPHSNHWAIFAEEHNCREPNYRQRQTGEGKEGEYPASSGTGASGNTDNIGQDDKPPASSRWPRSDDPWHSLHHGRFDRPSDFFSLDSFFDSFFDRFWFDDHFSSRIFHPFHQPFFFNMLNDDSATWPLAYLMFSPYSPLHLERQASYRAHRERGVFSSLISSLKPSSERDPAEPQWREAFEDLLRLENGKPMLDREPRTTLVKKESGTEWLKGLVQRGSLGDRWKYVSGPDGQGWSGITLESIEPADKDPPRTNESPTQQTQAVADWKDTKSAPETELDMYDRFLADIETREREFFKGAYESPLLRSLLEERRRLKEEIELFEKEGPSKDTDSWIDLVSDGDKNTVPETAPQSTSGSSTTGETRPTASATEQQPYVVSTRTSTERIRLPDGSIQTKTVKTKRFADGREETNESVEVMNPPPTSQDSVAGQEALENQKKRGWFWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y362</accession>
    <name>B0Y362_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_053070</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y362"/>
    <dbReference type="SMR" id="B0Y362"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053070"/>
    <dbReference type="HOGENOM" id="CLU_470065_0_0_1"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="PhylomeDB" id="B0Y362"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070691">
        <property type="term" value="C:P-TEFb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP51303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="580" mass="65107" checksum="F2BBE96748382704" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y372</accession>
    <name>B0Y372_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_053170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y372"/>
    <dbReference type="HOGENOM" id="CLU_037562_0_2_1"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="PhylomeDB" id="B0Y372"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="144" mass="16126" checksum="13CA931C770C66EF" modified="2008-04-08" version="1">MVYHHDRAGAAAKAVLKGTGAHKSRKIRTSTTFHRPKTLQLSRSPKYPRKSIPHEPRLDAHKVVLYPLNTESAMKKIEEHNTLVFIVDVKANKRQIKLALKKLYDVDTVKVNTLVRPDGSKKAFARLTPDVDALDIAATKLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y392</accession>
    <name>B0Y392_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA family metal ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_053370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y392"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053370"/>
    <dbReference type="HOGENOM" id="CLU_007127_6_1_1"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="PhylomeDB" id="B0Y392"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000002">
        <property type="entry name" value="Cora family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="663" mass="74694" checksum="F0CF6CE5677F5096" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4E0</accession>
    <name>B0Y4E0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_057460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057460"/>
    <dbReference type="HOGENOM" id="CLU_3105920_0_0_1"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="51" mass="5581" checksum="30B9015C8E5A79BB" modified="2008-04-08" version="1">MISLDGAKAILCHAFSSNLEWASVAEDDEADRVLHRDEQDGEPVQVGLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4R7</accession>
    <name>B0Y4R7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_070030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4R7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070030"/>
    <dbReference type="HOGENOM" id="CLU_080764_1_0_1"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4R7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="209" mass="22353" checksum="99C5BFCA1E895E49" modified="2008-04-08" version="1">MILSMSFTRRPLRLARWSQIRTVSTLEGNPHIYVFSNKPQGGSHTLSLLSSEPVNPKTAIGVTSKLPPSTDSFRENPNFLKILQEVISEYGHKDPDAISQAQVMVSTSGANISSGGVLMTGQSSRRRRESKDSSGGASGQGGVGSAGRGGWIHLSDSRRPPEYGRIAWPEDIFGSLEVDANGNFVGVNGNYQPSGTAPTESSLGTEYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5S5</accession>
    <name>B0Y5S5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ER associated DnaJ chaperone (Hlj1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_064420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5S5"/>
    <dbReference type="HOGENOM" id="CLU_043579_1_0_1"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5S5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="376" mass="41069" checksum="53607C519FFFDED9" modified="2008-04-08" version="1">MPSASASGADTGGSARSREHNQGNQDRKYTAEQKAAVIRIRKCSSTAYYEILALDKSASDGEIKKAYRKLSLLTHPDKNGYEGADEAFKMVSRAFQVLSDPDKKSKYDKFGGDPDSRFTPSAGPSGASPFGGFGGGGGGFPRSAGAGGPMFEEEISPEELFNRFFNGGFGGGGFGPFGTLGSHSSLVSLRAHTYGCYLGGPQFVFNMGGGPGFRVHQFGGPRPRRRPREASAQAEAAPSGWATFQSLLPLILLFVLPLLSSLFSGSSSPSGPSYRFDAAVPPHTMQRTTPKYNINYFVNPRDVEDYSAKKLRQLDTKVEVDYITKLRYECESEVHARDRMMQEAQGWFFPDVEKMKEARSMELKSCRQLDSLKGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5X9</accession>
    <name>B0Y5X9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endoglucanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_064960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5X9"/>
    <dbReference type="SMR" id="B0Y5X9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064960"/>
    <dbReference type="HOGENOM" id="CLU_031730_1_3_1"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5X9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760828" evidence="5">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="6">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="250" mass="26142" checksum="582F30BDD29D4974" modified="2008-04-08" version="1">MTLSKITSIAGLLASASLVAGHGFVSGIVADGKYYGGYLVNQYPYMSNPPDTIAWSTTATDLGFVDGTGYQSPDIICHRDAKNGKLTATVAAGSQIEFQWTTWPESHHGPLITYLAPCNGDCATVDKTTLKFVKIAAQGLIDGSNPPGVWADDEMIANNNTATVTIPASYAPGNYVLRHEIIALHSAGNLNGAQNYPQCFNIQITGGGSAQGSGTAGTSLYKNTDPGIKFDIYSDLSGGYPIPGPALFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6E6</accession>
    <name>B0Y6E6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_066660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6E6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066660"/>
    <dbReference type="HOGENOM" id="CLU_073919_0_0_1"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6E6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="240" mass="27311" checksum="BF2049ABF4F23F3A" modified="2008-04-08" version="1">MAIDILPLTKPDIPEAVVCIQKAFADDPYFRWVFNDPSKYNIHRNAASLSAHFLHGLHTHAPIYIAKYRPTPTDKHPPPSSAVVGVCWWYPPQGQPTWATWTQDWLLSFRQLVNNIRFGGRGGLNVRRYWIWKTLQARTHAELWTSPAGYYFCNVIAVSAEMRGMGVGRRLVEAVTGRADAEGVPCYLESSKGEPNLRIYERLGFRLVKEMECVDGWDACKVCLCEGPLFHRGYDMHGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6T4</accession>
    <name>B0Y6T4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNF7 family protein (Cta1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_068060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068060"/>
    <dbReference type="HOGENOM" id="CLU_079409_0_0_1"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6T4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="216" mass="24161" checksum="1B9F4897820347A7" modified="2008-04-08" version="1">MNRLFGTKNTAPKPTLDDAISKVDNRIASIDVKLASLNAELSTYQAKIAKMRDGPGKNALRQKALKVLQRRKQYEAQRDQLSQQSWNMEQAGMMQDNLKNVMTTVDAMKTTTKELKKQYGKVDIDKIERMQDEMADLMDIGNEIQESISRAYDIPEDVDEAELDAELEALGEESMFESAMGESSLPSFMQDEVAPPQFIDEPPEQAKVKEPAGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y797</accession>
    <name>B0Y797_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_073050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y797"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073050"/>
    <dbReference type="HOGENOM" id="CLU_005860_0_0_1"/>
    <dbReference type="OrthoDB" id="3903581at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="877" mass="98725" checksum="C565E90D39416BF2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8T1</accession>
    <name>B0Y8T1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_078450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078450"/>
    <dbReference type="HOGENOM" id="CLU_023133_1_0_1"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8T1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55326" checksum="7EC77CA7EF761653" modified="2008-04-08" version="1">MPSSVETASNWDFTPVLNLLRSPAYDGREQFHPVGHANLPPAFEKEDTEKTANDPSGVYPRLGDFGPLWDLLGTGSSAGVKTEQSPPPRASRTEQPQKSKPIQILKRPIATAKSVEHTIEQTPGAAPRPILGSRAFEAQLPKKKAVAENSTACQDLQSKVSDVSSSESSAEAESDGNFSVFDPPLLKKRGAVSFIPSQVCTPASNDEPCDTPPSSFDELEGSLTAETIKSLPAGRIRVHPIAYKSAADRRVGLLTKLLKKFPEYAEVVAQVGRSPCTKSNEQASRPIHVFVDMSNIMVGFHDSVKLARNIPVKTRIRRLPLSFQNFSLILERGRPAAKRVLVGSDRFAAIDESQKLGYEANILDRVHKVKHVTRQLKYRKNPRVSSREGGSGSETNDAPEERWVEQGVDEILHLKILESLVDTDEPATIVLATGDAAKAEYSEGFMKMVERALQRGWNVELVSFSQVTSFAYRRKEFRTKWGKQFRFIALDEFSEELLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y916</accession>
    <name>B0Y916_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NACHT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_079300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000739_1_1_1"/>
    <dbReference type="OrthoDB" id="2546325at2759"/>
    <dbReference type="PhylomeDB" id="B0Y916"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF11">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="230"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1954" mass="219397" checksum="012B3470CE61418F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y919</accession>
    <name>B0Y919_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_079330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y919"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079330"/>
    <dbReference type="HOGENOM" id="CLU_036837_0_0_1"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="PhylomeDB" id="B0Y919"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="58"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="416" mass="46893" checksum="8CFAF5F75F7018B1" modified="2008-04-08" version="1">MTSPFRVVEHIIPGQHIREHPHALRGRQETALKLAIKQYIPCDQTEPILENAVTIIGAHGNGFPKMREDLYAQLKKRSIPVRGIWIADASNQGASGVLNEHVQGDNTPWHDHSRDLLHMINHFRDDIARPIIGVAHSMGCTQLIQLSMIHPRLFSTLILYEPIIFGDQFQGPNPAITAVLRRDIWPSREKAEMQLRRGFAKWDPRVVDCYLRFGLRPVPTRLHNPENDPDIPPTAVTLTTSKHQEAWTYTIPNLEPESAGLNDLLLPDWDPVLERSAPFSRPEAWAAFRNLPFVRPSVFWVYGGRSWLAPPAAQESMVRATGTGTGGSGGVAKGMVDRTVSPKATHLVVFEEVGWCSEVAAAWLEKWFARYLREEEFWRTYQSKKSDPEMLRNSEASIHVAKVVVGPQGDVAKAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y980</accession>
    <name>B0Y980_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SesB-related regulatory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_080080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y980"/>
    <dbReference type="HOGENOM" id="CLU_000288_182_0_1"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="PhylomeDB" id="B0Y980"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="8">
        <location>
            <begin position="106"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="321" mass="36251" checksum="4AEFFA0811FE84F2" modified="2008-04-08" version="1">MGSFFSKNHTECDHDHDQLSEATDEMRPCTGLRVLHDGQSPTVDIIFVHGLTGHLDKTWTVPGSAAPWPQALLPTTIERARILAFGYDARVVDWNMVSQNRIGNHSRNLLQAVADYRENDMTNDRHIIFVAHSLGGLICEDALVVSSRSVEKYLRSVFNCTFGLAFMGTPHHGSDMAQWAETMRKFTSVFKQTNPELLRALERDSEVLARIQDEFHTLLRSRSKDSPLEIFCFYEEKPLTVVGTVVPMDSAILPGYLHASLPYDHRDMTKFASVDDPGFITVTNVLRRWVRAISEVAPRPAGQILNIYQMYRGTDKISGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9G3</accession>
    <name>B0Y9G3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_080930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9G3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080930"/>
    <dbReference type="HOGENOM" id="CLU_010194_15_2_1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9G3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="365" mass="39155" checksum="4C23F117E7F6FFE9" modified="2008-04-08" version="1">MSTGGSKSICPLMTEGVLESNRVRAIAVEIVLGEPDMKVRRRLWGKLESFGPGVIGRLLPDWDILLCKAESGPYKQATGGQTCISDCLWQCHWSRLNGIWGDLRTSDSVLKKYLVLSTNNDEMPSIKNSTIVIFGGSSGIGYGVADKCLSEGAVVHISSSNPTRITQAVSSLKEKYPEGQVTGHTCDLSLPDVEQGLVKLFEEIGSCDHIVYTAGDALAVRPLKDLDLQFIQKAGHIRFDVPLLVAKLALRVLKPGYTSSLILTGGAVGDRPQPDWAVVAGYAAGLYGMVRGLALDMKPLRVNFVSPGPVKTGLFTDELAEMFAKRTTLGKVGSVEEAAEAYVYLMKDMNATGSCVSTNAGSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9U4</accession>
    <name>B0Y9U4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-hydroxyacyl-CoA lyase</fullName>
            <ecNumber evidence="12">4.1.2.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_082290</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25375"/>
            <dbReference type="ChEBI" id="CHEBI:49188"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58783"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:25376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:67444"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:170012"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67445"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.63" evidence="12"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9U4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082290"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_3_1"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9U4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106359">
        <property type="term" value="F:2-hydroxyacyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000006">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000071">
        <property type="entry name" value="2-hydroxyphytanoyl-CoA lyase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000054">
        <property type="entry name" value="Putative 2-hydroxyphytanoyl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF2">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="19">
        <location>
            <begin position="57"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="17">
        <location>
            <begin position="250"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="18">
        <location>
            <begin position="455"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP48787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="655" mass="69924" checksum="048785EBB626B740" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA10</accession>
    <name>B0YA10_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_082960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with missfolded ER lumenal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA10"/>
    <dbReference type="SMR" id="B0YA10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082960"/>
    <dbReference type="HOGENOM" id="CLU_025069_0_0_1"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="PhylomeDB" id="B0YA10"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000025">
        <property type="entry name" value="Protein OS-9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760900" description="Endoplasmic reticulum lectin" evidence="12">
        <location>
            <begin position="24"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="13">
        <location>
            <begin position="161"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP48853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="520" mass="58265" checksum="CAD972BBB859CF98" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA14</accession>
    <name>B0YA14_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_083010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083010"/>
    <dbReference type="HOGENOM" id="CLU_038616_0_0_1"/>
    <dbReference type="OrthoDB" id="5578001at2759"/>
    <dbReference type="PhylomeDB" id="B0YA14"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="381" mass="41989" checksum="6F253E2E68E2841A" modified="2008-04-08" version="1">MVELISPPDPHTLLPPLLACLPTAFVSTRPPPVLLPLLSPILRQRVQILSSVSTSPTESWLRLLCWDSEKAERLQALVDGADFESHPVSGEIELPEEVHVAYKRVDEETLHSRILLPEYGLKAIYLWCRSDQDGGGPGWRVAELMPHESGAENDGVWSFSIGEANAQAKEQMLEDALREAERDQKVAPHTQEKNDEEDDDDGYWARYDATPGRTPSVKTPAPNQLSSLHRQDTSEASYFSRYADVQPAMDNHDPSEEQSEVGPTSLNGDMLASLLRQQLNNSSLEESVNGYANGTIADETAAMSLDHPRPSSTSSTASEAAVAKLEQEAEHQSACEVGVKQHISSNIKSLFRLAKITGISRAEFQSLVKTELELLNLSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA19</accession>
    <name>B0YA19_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COP9 signalosome subunit 8 (CsnH), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_083100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083100"/>
    <dbReference type="HOGENOM" id="CLU_108986_0_0_1"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="PhylomeDB" id="B0YA19"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="48"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="216" mass="24480" checksum="F43F175E8AC1E8B8" modified="2008-04-08" version="1">MDLPPLSREQLSTVLATASSSSALYETLSQYEGHACFLSTSNSEEAELLSLFYSSFFFSHLLLDDIYEARAMTKRMPQDLAQNDATLQNCLRLLRAVWQRKYEYVYKVLRDLPWPEMLKPTVRNYELHFQEKTLKEVSRAYEAIRPDAAANYLGLDVTAAKQGDPAIISKFTACGWRWDEQNGLLYPQPIITAREKIGHSSNGLSEVMALMGSHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAD2</accession>
    <name>B0YAD2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_084260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084260"/>
    <dbReference type="HOGENOM" id="CLU_1712834_0_0_1"/>
    <dbReference type="OrthoDB" id="5414143at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="153" mass="16831" checksum="E124ECF9BBAD117B" modified="2008-04-08" version="1">MGRVTATSGKATLGERISDWAFVEMNDVAIEKSFRPNHMFPVRGYQQPSRCKAGGEPLTNFDPLIEDGAHDGNYYRPSPWDAGDALLQDCTSYGHVGNKNDLSAATIEEYIIVSRGLNTTEHTQASFVVVGDSRSHVIDKDQRTSQARAPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAH3</accession>
    <name>B0YAH3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_084670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084670"/>
    <dbReference type="HOGENOM" id="CLU_021599_3_1_1"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="PhylomeDB" id="B0YAH3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="466" mass="52665" checksum="3775BE1782EA95C4" modified="2008-04-08" version="1">MVGVPRSAGCRTCIQRRVKCDEGRPECRRCRDRNVKCPGYQRRVKFYHQTPASLRNRKQKDSRHVAAPAVHALTPRASMDGNIVPSLVSTAIDTQMKEVFQYFVMVSFPGLFSAWRNRVELNWLDFVRHHLDTSSHALIWSLRSLSVWHLGRAQNDHDKMLASRHFYGRGLQHLIYSLRDPRTATSNLTLMAAIHLGIYEMLDGLGEKSWLAHSRGIGKLFQLRGPQAHRDGFGRTLLVAYRPFLVADAIVSEEPCFLEEPGWQAIVHDAIAFERSAGKSCPLSEIVELAFNEIVLCPGLFARTRAFVSQTGVKSEILRESLVARITRCRDRLVEFHGEMQPLIVKYNKDNMLKWEEDTKSPIPTEYGPKVAKFAARGARSAIAVLNQLLVLIEADKNRSFLDTKPPCRNTLWKLPAGSIASSESQEKQPTAYDAHEDDSPDRLDQLALSMGMLAIRSGKPPAHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAP0</accession>
    <name>B0YAP0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epsilon-lactone hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_085330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085330"/>
    <dbReference type="HOGENOM" id="CLU_042179_3_0_1"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="PhylomeDB" id="B0YAP0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="107"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="39985" checksum="7103E702AC8E1107" modified="2008-04-08" version="1">MRTLTVCDKLDAFNGWFSVGVEALYAAVTGFFRGSSGADTYHHHLIQAIVKKLTRRFSPLQLQYIFKSYDQLYLQYCQKTGLQPHFVSNSRGLKGFWIGSPSAKYIVIYFHGGGFAMAATAPYLDFWPRIQTTLANAGIENAWFHCTYTLTPHAAYPTQFREAVEALRYILEDVGHSPSQVLLVGDSAGANLCLAVLSHLTHPSEDVPELVINEPIKGVVLMSPWVSFRHHWPSVEASEHRDIDAAEVLTEWSRAYLNGRESNNYIEAVEAPEWWWDNIRVRQTLVLAGGDEALLDPIKTWVNSFKKANHDTALVIGERECHVAPLVWPMFGDYHETQQERALKHWLLERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAW1</accession>
    <name>B0YAW1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase SirN-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_086020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAW1"/>
    <dbReference type="SMR" id="B0YAW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086020"/>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="PhylomeDB" id="B0YAW1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="271" mass="29554" checksum="92CC65B8C3E980D8" modified="2008-04-08" version="1">MDNFMEMTKKLGHQPELLRLRALDATYDDALEGKLVVAPLDMSEPGKKILDSGTADGTWLRNVRSKQSVPHDYYGSDVEGELFPKDPDGITYFAHSFKDPWPQQYLGFFDLVHIRGSLAGSAPEGPAPVIQNLTTLLKPGGWVQLMEMNAFSPPPNGPAMTDFAKMASEMFTGIGVGDFANNNKSMLEDAGLKNVQEKRVIVNLGKKAKPELHDQSIHGVTGPIVPLTSVARTVKSSFTGEQLDALPARVKEELETEGGQVEMIIAFGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAZ4</accession>
    <name>B0YAZ4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tryprostatin B 6-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Fumitremorgin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_086350</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tryprostatin B + reduced [NADPH--hemoprotein reductase] + O2 = 6-hydroxytryprostatin B + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35955"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:72760"/>
            <dbReference type="ChEBI" id="CHEBI:72762"/>
            <dbReference type="EC" id="1.14.14.118"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.118" evidence="14"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAZ4"/>
    <dbReference type="SMR" id="B0YAZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086350"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="PhylomeDB" id="B0YAZ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0349">Heme</keyword>
    <keyword evidence="9 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP49187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="559" mass="64183" checksum="4B066BCCA3A0CC27" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCA3</accession>
    <name>B0YCA3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_089480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCA3"/>
    <dbReference type="HOGENOM" id="CLU_050730_0_0_1"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="PhylomeDB" id="B0YCA3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF3">
        <property type="entry name" value="THIOESTERASE-LIKE SUPERFAMILY-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="2">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="207"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="40969" checksum="DB0E89393FEFBF23" modified="2008-04-08" version="1">MAVPAANQAFEEAIKVTPVNSHRYSAVLRDEWCIGTGTSPTICSVAIRNHCELIWHRIVPNGGYTTAVLYRLAITHFAHTHPRRYDATATPISMQLAFLRRTAVGPAVLEVQDTKLGARTSTIHVALLQPSEKGKKKGAQTGSSASSEDGGNLEVKVAGYITVSPATAEVGVSAPSSWTLLPEAIRGSGPQGRVNLAALRETGRDGQWVRLVAPFPKFRRASQQVELYGPDPALGKTPVVDQWARFRPGGNTEARWTNEAVAFLVDMFPMALDGFDSMGKVTKEGGTTDDAAETESAKGKLAKYWYPTVTLNIDFKKRLPASGVEWLYSRVQTKSVRNGRTDLDVIVLDEQGDVVALSTQVGLVVDASRNIGQRKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCF8</accession>
    <name>B0YCF8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_090040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090040"/>
    <dbReference type="HOGENOM" id="CLU_038115_1_2_1"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="PhylomeDB" id="B0YCF8"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="70"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="240"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP48289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="316" mass="33888" checksum="38A705766E576D69" modified="2008-04-08" version="1">MFYSIAIRQDGLIMTNILFQSRRKAPLREGRLQQATLDLLSGSDIQFRRETRLDIALVKNLPIALIFLPAADIPTFVGEGRVDLGITGRDQVAEHDAQLAEGEVSGVEEIMDLGFGGCKLQVQVPQKGDITEAKQLIGKNVVTSFTALTQAFFSRLEGVELGQKLSTKIKYVGGSVEAACALGVADGIVDLVESGETMKAAGLKAIDTVVESTAVLVKSRSTKNPLVDLITSRISGVITAQRYVLCQYNILRSGLSVASKITPGKRAPTITALEEEGWVAVSSMVEKKKIATVMDELLKVGASDILVLNIANSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCS9</accession>
    <name>B0YCS9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_093070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCS9"/>
    <dbReference type="HOGENOM" id="CLU_106801_0_0_1"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="PhylomeDB" id="B0YCS9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="157" mass="17081" checksum="0255DD13C9FE0C6A" modified="2008-04-08" version="1">MAAERTNVSSDLVWQITRNQNAFLVKRRTGGGSQFSRDPLNLQNKQSFKYAGYANTKAVGVQATENGGVVVITKKPGNPQQPAKNLVSVSWGPNAATRKIYKAVASKTAKNGYRADLREDAVARVSAIRRSQKPKKDAAPKKLRGAQARKAAEQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD00</accession>
    <name>B0YD00_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_093780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093780"/>
    <dbReference type="HOGENOM" id="CLU_017135_0_0_1"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="PhylomeDB" id="B0YD00"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19178">
        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1420.10:FF:000013">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="34"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="492" mass="54396" checksum="975A2E4A3E2F5C32" modified="2008-04-08" version="1">MSSTTHFPDSDSFQRQSDEFITWLAGKPGVKINSKISIADLRSKSAGRGVVARSDIFDGEELFSIPRGLVLSAQNSKLKDLLSQDLEELGPWLSLILVMMYEYLLGEQSAWAPYFKILPKSFDTLMFWSPSELRELQGSAIVSKIGKEGAEDSIMQMIAPVVRANPSLFPSVDGLASWDGEAGSHALLRLAHIMGSLIMAYAFDIEKVEDEDDENNDEEDGYVTDDEQDQSSKGMVPLADILNADADRNNARLFQEDDSLVMKAIKPIRVGEEIFNDYGELPRADLLRRYGYVTDNYAQYDVVELSLDQICRSAGLQNADIESYPPLAFLEDLELLDDGYVIPRPSPEDSLTDFLPDELLVLVKTLTLSSEQLEHQKSKSKAPKPSFGHAEAAILLKAVQLVGSQYPTTVAQDEEILSGLVQSEASQPLNQTDRRQKMAIQVRLGEKYILQTLANMLEKFITNSAQSNGGSGLKRGANGDSGDSRRTKAPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD56</accession>
    <name>B0YD56_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_094350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094350"/>
    <dbReference type="HOGENOM" id="CLU_004457_0_1_1"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="PhylomeDB" id="B0YD56"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="446"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="821" mass="93503" checksum="F8336FC33B3F72AB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDA2</accession>
    <name>B0YDA2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_094830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094830"/>
    <dbReference type="HOGENOM" id="CLU_017280_0_0_1"/>
    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="PhylomeDB" id="B0YDA2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="323"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="663" mass="73484" checksum="6F5849685CF93439" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDE1</accession>
    <name>B0YDE1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_095240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDE1"/>
    <dbReference type="SMR" id="B0YDE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095240"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B0YDE1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="531" mass="58257" checksum="A676A4F09F313D00" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDE2</accession>
    <name>B0YDE2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oleate delta-12 desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_095250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095250"/>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="PhylomeDB" id="B0YDE2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="396" mass="44911" checksum="70A749D7AC2BAF93" modified="2008-04-08" version="1">MAGKMAEVRQRDVQTETEVVQDSIPSLKSLKDAIPKECFESSLAISFLYLARDILYCAILTYGAFHIHLLPSLPLRVLAWATYGFFQGCVGTGMWILAHECGHGAFSPYQGINDFIGWATHSFLLVPYFSWKITHARHHRYTGHMEKDTVFVPWTDEQLAKKRNVRIEQLKHFAEETPIVSFLQLIGHQLGGWQLYLLTNATAGAQSWPEGKPKTGPASHFNPVGALWTPSQRLSIAISDLGLLIMAAVLYYASTQIGAWNVVLLYFVPYLWVHHWLIAITYLQHTHPSVPHYTPEAWTYTKGALATVDRTMGFIGRHFFHEIIDYHVVHHLFSRIPFYKAEQATWAIQPLLGAQYHEEKEQSFLGSLVTTFRKCIYVSATGQPGVLHFVKADEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDL8</accession>
    <name>B0YDL8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_096040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDL8"/>
    <dbReference type="HOGENOM" id="CLU_2183356_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="109" mass="12099" checksum="D38EDBA4D9F37774" modified="2008-04-08" version="1">MLFADVYSINVNPINKPAAVTVPVRSKYHVIPAHHSLAHLASFPFKRPILEAVAALPAHPIFCVLILVPELHGNTVICESKKLLAESVIMFTLPFAGQERDNRFCAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDN5</accession>
    <name>B0YDN5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_096210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096210"/>
    <dbReference type="HOGENOM" id="CLU_021695_3_1_1"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="PhylomeDB" id="B0YDN5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="525" mass="56877" checksum="9E2C9FED018DFF4B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDT1</accession>
    <name>B0YDT1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096680"/>
    <dbReference type="HOGENOM" id="CLU_1085768_0_0_1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="PhylomeDB" id="B0YDT1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="256" mass="28827" checksum="B2511E2DCB3E16F8" modified="2008-04-08" version="1">MFDLGASYLRQHKLEEAEGILLQALRGYEENIQPDKPIDISHRLTLNLINNLAGLYREGRKFGKAEELYQLAIDGYKKALGPDNEETLSRMRDLGASYLRQDKLEEAEAILLQALRGYEKNIQPDTPIDISHRLTLNHVNNLAGLYKKGRKFRKAEELYQLAIDGYKKALGPDNEETLSRMRDLCNLRKELWKLKASQADIAPMGGDGYPKAAPTPDTLVTQKNSGMEEASLSGSGGDDHYSERRHESGKVAEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEA7</accession>
    <name>B0YEA7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_098510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098510"/>
    <dbReference type="HOGENOM" id="CLU_031225_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="B0YEA7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="583" mass="63724" checksum="5B42BCA8FBE825FD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEP5</accession>
    <name>CUTI3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable cutinase 3</fullName>
            <ecNumber evidence="5">3.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cutin hydrolase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_099910</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (By similarity). Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="5"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEP5"/>
    <dbReference type="SMR" id="B0YEP5"/>
    <dbReference type="ESTHER" id="aspfu-q4w9z4">
        <property type="family name" value="Cutinase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP47389">
        <property type="protein sequence ID" value="EDP47389"/>
        <property type="gene ID" value="AFUB_099910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099910"/>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="PhylomeDB" id="B0YEP5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395253" description="Probable cutinase 3">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P11373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P52956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="217" mass="22483" checksum="10735C585B7690FA" modified="2008-04-08" version="1" precursor="true">MSLRSLFVAGLATLALAVPAPQIQARQGMSSNELESGPCRDVTFIFARGSTEQGNMGLIVGPGVCSSLKKDLGSDKVACQGVGGAYTAQLAPNFLSQNTNQASINAATDMFDLANTKCPNTKIVAGGYSQGSAVIDNTIQALGSDLKAKVKGVVLFGFTRNVADKGQIPGYPKDQTKIYCAVGDMVCVNTLIITPAHLTYGADAGDAAKFLASKVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YES5</accession>
    <name>B0YES5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_100210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YES5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100210"/>
    <dbReference type="HOGENOM" id="CLU_039522_1_0_1"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="PhylomeDB" id="B0YES5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="4">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP47419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="402" mass="44685" checksum="AAED1842B2986CE6" modified="2008-04-08" version="1">MVSLWPWKGEDNSPAFFEKALSALSTKITQTKSQLDLHRQHARRFKALWTLYTTFAYLLYSIILALVLGWQNWGMTEYAAIIGGPVLIYVVRAVASKFFDYRINKTQRHLEDLQKQRDETIEKLKVATKYNSTQQLLEKYGAESPKPSRPKGGDEKRKTDAKRKQPSTPQQPVMRTGLPPPPTANIRRPTPAQSPVSSPGQPQSPPSYLIQEQPQLQNLHPPVPPALDEPGFAPNAFPSAPQYVEHSHWYDRLLDILLGEDETQPKNRMALICATCRLVNGQAPPGVKTLEELGRWRCGSCGAWNGEESEAKKMLAGMRDQARSADGAWESVAKPDSDSHSAGDATDEAVMVATSEDEQVEARSSGEESQNEADQQPQEQETPEASGNSKSGRGRRKGTRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF16</accession>
    <name>B0YF16_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_101240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101240"/>
    <dbReference type="HOGENOM" id="CLU_1288639_0_0_1"/>
    <dbReference type="OrthoDB" id="5130616at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="2">
        <location>
            <begin position="45"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="214" mass="24109" checksum="CE21173D4168BDF7" modified="2008-04-08" version="1">MACSSSCLEPNFTTLSGRYCADAPRVTLVVAPAARKEPPFDTRPMLQRLKTLHIISNDVRDVYSHWQFPPFFHLPSLRNVNMGTVKEYKGWTRLNHPAVSSTSGKSPVASLVLESHCNGRDGVAEFITSCANLKEFRYQHDDDEDWAQTCKNFQPQKIYKALLTQKHSLEVLHLSHNVQVSRFPSDDKDENGPVPLDLITGGAQKPTGYSYPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF63</accession>
    <name>B0YF63_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_101690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101690"/>
    <dbReference type="HOGENOM" id="CLU_1644174_0_0_1"/>
    <dbReference type="OrthoDB" id="4486432at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033852">
        <property type="entry name" value="fulvocin_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760670" evidence="1">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="161" mass="17097" checksum="56B3367DE49B2C98" modified="2008-04-08" version="1">MKFTFSFIALGFASFAQSTSVSGSSSLLPGNTNTASAAWLTHFDQFRQQHEPLNPAQSAVIDTATDLAKQGQDFDPKAMDDLKNDAISAFGFKDAKSLLATMGNKSLQTRDDAKEDIECGCSTQSDWCDSGYHCAGGGCTQTGSGCGTLYKYACDGLCRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0YFA1</accession>
    <name>B0YFA1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_102080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003548_0_0_1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="PhylomeDB" id="B0YFA1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1456"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1165"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP47214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1763" mass="198882" checksum="A22EA67A5488396F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJP2</accession>
    <name>H9CJP2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_m0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="2"/>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353061.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJP2"/>
    <dbReference type="GeneID" id="11948059"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFE02842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="245" mass="28420" checksum="DAC36C4B8AFA5510" modified="2012-05-16" version="1">MLWFLKVKKFIYILSNVILFTCQNNIIIWYFICIIASILSCFDFYYLYLFSLDIWSDEINIDASTLNINVSTFNIDVSTLNMSSGDEGNYFFWFGGGDPGNNQGGNTNPEGGAIIGIDDQNKKRKKEDIWQYSIYDIYTKPYNPLGNRPPMCDRQLGELIECKAQLYQRFVPSRYPDLRVGDVFNTDSIIDKIARERLLGHILDYKFILTSSYNELELNLDTGYHKLYTVKITPLLIYSLKNSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJP3</accession>
    <name>H9CJP3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_m0440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="2"/>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353062.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJP3"/>
    <dbReference type="GeneID" id="11948060"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFE02843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="210" mass="23700" checksum="8454DCDB1F5AC808" modified="2013-02-06" version="1">MVQIPKILQAAKIIGLCLISPPKPHGFASLPLQSATDPLSGLNRIIKAKQNEILEAQEEINAETEYFYKKLDYLSDWCDTNGAILTLTFKHSANGCVKILGNDISYYEPENYIAKNPELIIKDKFIGYIDENTGEKSIKEILTNFERDQISDVADKIYETGQHLDYLKKLLQQINENLTNIDVKHAMVTEPSIDQCVDVINLINTLINCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM16</accession>
    <name>B0XM16_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_001680</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001680"/>
    <dbReference type="HOGENOM" id="CLU_000335_0_4_1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="PhylomeDB" id="B0XM16"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001076">
        <property type="entry name" value="ATP-dependent DNA helicase MER3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000012">
        <property type="entry name" value="DEAD/DEAH box DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000950">
        <property type="entry name" value="probable ATP-dependent DNA helicase HFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="242"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="456"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1047"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1098"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1294"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1343"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1101"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1294"/>
            <end position="1323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP55473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1439" mass="160648" checksum="76FAD9355BF8DFC1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMZ2</accession>
    <name>B0XMZ2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">AFUB_003810</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Cytoplasmic vesicle</location>
            <location evidence="1 17">COPII-coated vesicle membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Endoplasmic reticulum membrane</location>
            <topology evidence="2 17">Peripheral membrane protein</topology>
            <orientation evidence="2 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Peripheral membrane protein</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMZ2"/>
    <dbReference type="SMR" id="B0XMZ2"/>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="PhylomeDB" id="B0XMZ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="19">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="20">
        <location>
            <begin position="127"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="22">
        <location>
            <begin position="403"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="21">
        <location>
            <begin position="521"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="18">
        <location>
            <begin position="636"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EDP55684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="780" mass="86918" checksum="423A00EC88FBDB0F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMZ6</accession>
    <name>B0XMZ6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peroxisomal carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_003850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003850"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="PhylomeDB" id="B0XMZ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="116"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="209"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP55688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="335" mass="36119" checksum="9A1F9066C437CD16" modified="2008-04-08" version="1">MTGQSKAMRLSPWGSAVAGATGAVLANAIVYPLDIVKTRLQVQVKSDKTDGSDGTMHYESTLDAINKIVESEGIEGLYSGIVGSLIGVASTNFAYFYWYSVVRSLYMASDRVPKPPGTAVELSLGAVAGAVAQIFTIPVAVITTRQQTQPKGEKKGLIETGREVVNSEDGWTGLWRGLKASLILVVNPAITYGAYQRLKDIIFPGKNSLKPWEAFLLGALSKALATIATQPLIVAKVGLQSRPPPGRGGKPFKTFGEVMRYIIEKEGALSLFKGIGPQITKGLLVQGLLMMTKERMELMFVLLFAYLRKIRQEKLRKAVDAAASKAKTSLPATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN07</accession>
    <name>B0XN07_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_003960</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN07"/>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="PhylomeDB" id="B0XN07"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="348"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP55699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="542" mass="57877" checksum="FC5211F8DC5D16D0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN15</accession>
    <name>B0XN15_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_004040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004040"/>
    <dbReference type="HOGENOM" id="CLU_065618_2_1_1"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760464" evidence="3">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="250" mass="25515" checksum="99AD27A61E1515DD" modified="2008-04-08" version="1">MRFVTVAISALVAMASAYTQPDYSKPPQGNAILKPGLNEQVPVGKPYTITWDPTTEGPVSLVLLRGPSTNVVPLSTIVESIPNTGSYSWTPSTDLENDVTHYGLLLVVEGTGQYQWSTQFGISNPGKAADTPAASVTATTSATSEVETPAASSPADSNVTLVTTETTTWCPESTAKPTSIPVIVPTGAPSIPSGSPTPSAYPSSTLISKTYSPSGPSGTSPTPILFTGAADRTTVSVGAVAAGVLAVLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN36</accession>
    <name>B0XN36_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_014450</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN36"/>
    <dbReference type="SMR" id="B0XN36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014450"/>
    <dbReference type="HOGENOM" id="CLU_016552_1_1_1"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="PhylomeDB" id="B0XN36"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="146"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="449"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP56726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="507" mass="54586" checksum="A89500294BC38D69" modified="2008-04-08" version="1">MRGSEASGPGAIFGAPSTLTTSVIRNPTSFLSSSTPLPSTDADVIAQNVEHVLLSLTSHNDGGLVGVSGNSSGSTGKGILIGVLSAFGSATVAVLVLAIFFFFKYTRRGRIFLDRIGRPGEFDDEQAFAREEAEALEVMDDMARSEYMRAKSFVEANPPESMQTDISLSQFLAIQEKGVSAWEFQPELEIANCFVEGRTEIEFYDSECSVQTNLPVPKQNDVYYWEAKIYEKPESTLISIGMTTKPYPLFRLPGFHKTSVAYLSTGHRRYNQPFSASPYGPALAQGDVVGVGYRPRSGTIFFTRNGKKLEDVVHGAKTQNFFPTVGANGPCTVHVNFGQMGFVFIEANVKKWGLAPMTGSLAPPPPYGSEQGSILLESGRESAAQISQRVYQDARTSSTVRIPPSRSPGPVRSPTDISLAPLAHIPSHEDVGEGSSHANTIADEQTALLNPTDLDQVPPPEYSSPDGSRRGSDITGDLPNQSSPPIPSYDAAVGNQADNTLRPDGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNB0</accession>
    <name>B0XNB0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_004320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004320"/>
    <dbReference type="HOGENOM" id="CLU_000995_6_1_1"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="PhylomeDB" id="B0XNB0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="306"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="677"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP55735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="892" mass="98594" checksum="ABB331B4E283CCEC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNB8</accession>
    <name>B0XNB8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_004400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004400"/>
    <dbReference type="HOGENOM" id="CLU_059606_2_1_1"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="PhylomeDB" id="B0XNB8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="97"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="32566" checksum="652E5758E5205D95" modified="2008-04-08" version="1">MANRGYDVVVDVDAEGDLGHTDLQEDLEFHPSNFENDPRSAKVQQDSTPFLGAGTSRGRDRSPGGTPSKHAWWSIHYYSQFFDVDTNEVLRRCVSALYPRTNFLDVLEGNADLYGPFWIATTVVVILFLTGTISQWLSNNNSKHFAYDFTLLSGAAGLVYGYTGVIPIALWGALRWFGSSTADLIECWALYGYSNLVWIAVALVSWSPLTALNWALVGVGFGWTVFFLLRNLYPVLSATDAKTSKILLIMVIVLHAGFAIAIKILFFAHASPVSKKNKDHDDDDHDDKRRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP55</accession>
    <name>B0XP55_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_006000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP55"/>
    <dbReference type="Allergome" id="9532">
        <property type="allergen name" value="Asp f RPS3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006000"/>
    <dbReference type="HOGENOM" id="CLU_058591_2_0_1"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="PhylomeDB" id="B0XP55"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="266" mass="29201" checksum="61211003C9C69298" modified="2008-04-08" version="1">MAAVQGAISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKEFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKAGPQKTLPDSVTIIEPKEEQPVLQPMSQDYGAKALAAQQLAEQQRLAEQQAAEGQEGAGAEAYAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPD4</accession>
    <name>B0XPD4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Urea active transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_016950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016950"/>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="PhylomeDB" id="B0XPD4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF1">
        <property type="entry name" value="ACTIVE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="701" mass="75468" checksum="94560EE41B3B763D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPJ0</accession>
    <name>B0XPJ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc metallopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_006650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006650"/>
    <dbReference type="HOGENOM" id="CLU_031758_1_0_1"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="PhylomeDB" id="B0XPJ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="473" mass="52026" checksum="5ECA7EFD7A68C792" modified="2008-04-08" version="1">MPPSLTKQITQIEGVRLAGANDIEWDITINYPGKSAKGTIVAITPHRSSSPNDNCSPLALPALTHPHIHLDKAYVHSTREYAHLLPAEGSFQEALSFTAQAKKQFSQADLMKRGEWLLAESVSAGVTAMRAFVEVDHTVKLTCLETGLKLKDEWKECCNVQIVCFAQDPIFSGEYGDENRDLIEKALERYPQIDVIGTTPYVESSTDAARRNIGWAIETAVKLDKHADFHLDYSLDSSKEALVWYVLQALQRNNWTSQSSSRRVMFGHCTRLTSFTDKEWSDLAKEIRDNDLPVSFVGLPTSDMYMASPYPAANAPHNRPRGTLHVLKMISEHGLDAIIGVNNVGNAFTPWGSADPLSLACLGVGIYQAGTQKDAELLYECVSTRARAAIGSLGSQGGSSLMLKEGDQPDLVVLHNVDDTGCNVLRPRNSVADVVWDPPARVSRHIISNGRLKLPPHPMYPGTARYAFKDSDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ41</accession>
    <name>RGLT_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor rglT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulator of gliotoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rglT</name>
        <name type="ORF">AFUB_008610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2020" name="PLoS Pathog." volume="16" first="e1008645" last="e1008645">
            <title>The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence.</title>
            <authorList>
                <person name="Ries L.N.A."/>
                <person name="Pardeshi L."/>
                <person name="Dong Z."/>
                <person name="Tan K."/>
                <person name="Steenwyk J.L."/>
                <person name="Colabardini A.C."/>
                <person name="Ferreira Filho J.A."/>
                <person name="de Castro P.A."/>
                <person name="Silva L.P."/>
                <person name="Preite N.W."/>
                <person name="Almeida F."/>
                <person name="de Assis L.J."/>
                <person name="Dos Santos R.A.C."/>
                <person name="Bowyer P."/>
                <person name="Bromley M."/>
                <person name="Owens R.A."/>
                <person name="Doyle S."/>
                <person name="Demasi M."/>
                <person name="Hernandez D.C.R."/>
                <person name="Netto L.E.S."/>
                <person name="Pupo M.T."/>
                <person name="Rokas A."/>
                <person name="Loures F.V."/>
                <person name="Wong K.H."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="32667960"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1008645"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Transcription factor that is involved in protection against oxidative stress (PubMed:32667960). Binds to promoter regions of the gliotoxin (GT) biosynthetic genes gliZ, gliF, gliT, gliM, gliA and gtmA (PubMed:32667960). Two related but different DNA motifs (5'-TCGG-3' and 5'-CGGNCGG-3') are specifically enriched among rglT binding sites in GT-inducing conditions (PubMed:32667960). Also indirectly regulates the expression of gliP, gliG, gliH and gliN (PubMed:32667960). Plays a key role in resistance against exogenously-added GT and GT biosynthesis, mainly through the direct regulation of gliT (PubMed:32667960). Furthermore, rglT is important for virulence in chemotherapeutic mice with invasive pulmonary aspergillosis (IPA) (PubMed:32667960).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Leads to high sensitivity to allyl alcohol, a compound indicative for potential defects in carbon catabolite repression (CCR), but does not affect growth in non-stress conditions, nor in the presence of 2-deoxyglucose (2DG), an additional indicator for defects in CCR (PubMed:32667960). Also leads to sensitivity to acrolein, menadione and t-butyl hydroperoxide (PubMed:32667960). Abolishes the production of gliotoxin (GT) and accumulates bisdethiobis(methylthio)-gliotoxin (BmGT) (PubMed:32667960). Leads to reduced expression of gliZ, gliT, gliF and gtmA in GT-inducing conditions (PubMed:32667960). Loses all ability to protect itself against exogenously added GT as well and reduces virulence (PubMed:32667960).</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ41"/>
    <dbReference type="SMR" id="B0XQ41"/>
    <dbReference type="EnsemblFungi" id="EDP56155">
        <property type="protein sequence ID" value="EDP56155"/>
        <property type="gene ID" value="AFUB_008610"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008610"/>
    <dbReference type="HOGENOM" id="CLU_026660_1_0_1"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR RGLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000454487" description="Transcription factor rglT">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="32667960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="32667960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="410" mass="44548" checksum="89E28C422A33C872" modified="2008-04-08" version="1">MQFDSLPLPPSSSHDTTSVPPLKRHAACDECRKRKLKCSGEATGCSRCLKQSLPCHYSLQKPMGRPPKKRPREDNDASVYEITDNGMWADIDDGGILTEEAGAEATAASDALRLCPPVYTAPMRMPQAFPNLLSTDDSHNHLWQLESGRSLDPIPATTGPWPDFSSVTAATSSPFTLPSSLTLIDSPSVSSPSSDGGNSSQCTCLSYLYLCLSHLSSLAPFPISQHTLCSLFIAAKTARAVIRCEVCPTSFALGMQNVMFTGTLLNVIADAWLRVSQADAEELGKLAAPPAYVASVTQNSPNPAEAWKDWLRQTVRSAITGGPADPAGQVKCSDSPTLLSLIEEMEARQHRWHRTRTVESPNEPGSCSPVSHEDHREEDMLCFRVIRSARDVIAKFEFAPHEYPEGVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQT3</accession>
    <name>B0XQT3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Quinate pathway repressor protein QutR, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_011070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011070"/>
    <dbReference type="HOGENOM" id="CLU_008871_0_1_1"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="PhylomeDB" id="B0XQT3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000320">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000019">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002254">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="9">
        <location>
            <begin position="583"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="8">
        <location>
            <begin position="724"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="10">
        <location>
            <begin position="865"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="922" mass="101995" checksum="7DABDFAD67CDC8D2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQW0</accession>
    <name>B0XQW0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_011350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011350"/>
    <dbReference type="HOGENOM" id="CLU_019699_3_2_1"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="PhylomeDB" id="B0XQW0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000040">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="431" mass="47632" checksum="CF752AE4E33731EB" modified="2008-04-08" version="1">MPPPLLYNVLPAALPAHCEPSSPFLAAVSSHLHICLPTPLALLSSILGTLSIISWLFAQLPQIYKNYQLQSTSGLSLFFLVEWCLGDTGNLVGALFTRQAAWQVIIAAYYVLVDVTLVFQFFWYTHYKGRRVAYGGHSHSHHGEDAGSFLEGVPLSEEDSITDIPPRKPATEGSATKDEELLKKSSPITMNHQPLLYTNEKLSSSRRTITRSSSGPSLPLASTRTLLLASMLCAVVANAQPTEHHLPPAASQQTTLLVGRISSWISTALYLGSRPPQLIKNYRRKSTAGLSPLLFMAAFCGNLFYSASLATNPNAWYDFPPWGGRGWAGADGNKRLEWVGLSIPFFLGAFGVLFLDGCMGLQFLMYGAPDEEQVVPVMYAERRSRWTRVRGWMRGWIPSVPPRRASHDTSVQESQALLRGERERYGTVYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR72</accession>
    <name>B0XR72_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_012340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR72"/>
    <dbReference type="HOGENOM" id="CLU_048445_1_1_1"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="490" mass="54340" checksum="904E342D52BCCD1F" modified="2008-04-08" version="1">MANFTYSRCQRHNDEKKIMKLMTTFLLVVIVIYSYLSQFILSRPSLSVEQSFSSFFYSRASIINHILSTGNMEGMENDDSSAAVTFPSEDDRSCVSETPALDCFGVGVPPASPQASLAQGELELDSSLSQTSQSGIIDASTSPADSKAPFVRGHRRRSTHVSRRDLQKFRTEVLGIVSDPSLWCEEAGGSPASINPSTLDELNTAFAFASMSLNNSSGIPSNNPGSGMFPNYVDNTANSANLPNASRQSMSPAMPSPSTQVNGAGMPGMNAGIPMNAGHQMDLHHLYEMVLELSEVLKNNRETTKSIVSTAEEIMRLQKRASSEGTTPSLQQVNGEISAARIAELERALAKEKRLVEILKQEQVENTKLIGEYEAAVGTMVEQIRNYCQNNNMNYLAQKRHYNNLLQAERDAHLESRLDRDHWHAQTMKCAEMIRTAYRLRCEEEELPIRIVSGLQNEVRAYRNALGMEPEKPEEEYGWEILKDVPPSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRB1</accession>
    <name>B0XRB1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenosine deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_012730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012730"/>
    <dbReference type="HOGENOM" id="CLU_039228_3_1_1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="PhylomeDB" id="B0XRB1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP56562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="38857" checksum="B2A111446B3FB8BA" modified="2008-04-08" version="1">MDVSKPVDAAFTKALPKVEVHAHLSGSISRQCLHEIWLKKKAQHPDFDVEDPLVVMPPGKVDYSLQTFFSVFSKSIYQLCNDLDSLAYATSSVLQDFLADGVRYLELRTIPRASPTLAFTRTEYLTTVLTTIETFLSAHSSQISVYLILAIDRGNDTAADALSIVDLAIAHRPRVVGVDICGNPTKGDVALYGPALAKAKAHGLGITVHFAETEASGSERELSTLLSFRPDRLGHVIHVSEDFKREIARRRLGLELCMSCNVHAEMIDGGFPAHHFGYWRHVDCPVVLCTDDMGFFCSPVSNEYLLAAEHFDLGRAELLALCRESVDVIFGGQAEKERMRGLLLDFEDTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRJ5</accession>
    <name>B0XRJ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002690"/>
    <dbReference type="HOGENOM" id="CLU_1834713_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="140" mass="15662" checksum="C1F5C8D170E32755" modified="2008-04-08" version="1">MTWDHEADAKVRLSLTRSINTNADRNSFSSESSPPVTSSSTTKTLPNIWDPVSTHINQITTSTIKKQNFAESNVSERILGLAALPTGIPLLFLLRRNANAAAQRRTPTVMAQRRTRPALRKLRRLRKRRTDLLSTALELG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRM8</accession>
    <name>ARO1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-dehydroquinate synthase</fullName>
                <shortName evidence="1">DHQS</shortName>
                <ecNumber evidence="1">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="1">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="1">EPSP synthase</shortName>
                <shortName evidence="1">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Shikimate kinase</fullName>
                <shortName evidence="1">SK</shortName>
                <ecNumber evidence="1">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="1">3-dehydroquinase</shortName>
                <ecNumber evidence="1">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="1">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroM</name>
        <name type="ORF">AFUB_013230</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text>Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="1"/>
    <dbReference type="EC" id="2.5.1.19" evidence="1"/>
    <dbReference type="EC" id="2.7.1.71" evidence="1"/>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EC" id="1.1.1.25" evidence="1"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="5SWU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B=1031-1289"/>
    </dbReference>
    <dbReference type="PDBsum" id="5SWU"/>
    <dbReference type="AlphaFoldDB" id="B0XRM8"/>
    <dbReference type="SMR" id="B0XRM8"/>
    <dbReference type="EnsemblFungi" id="EDP56612">
        <property type="protein sequence ID" value="EDP56612"/>
        <property type="gene ID" value="AFUB_013230"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_1_2_1"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="PhylomeDB" id="B0XRM8"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000015">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000483">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018508">
        <property type="entry name" value="3-dehydroquinate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRR4</accession>
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        <name evidence="3" type="ORF">AFUB_024560</name>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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        <source>
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    <accession>B0XRU0</accession>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024820"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_7_1"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="PhylomeDB" id="B0XRU0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="89"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="519" mass="57388" checksum="508951FC0B7BAEE3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS19</accession>
    <name>B0XS19_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_025620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS19"/>
    <dbReference type="HOGENOM" id="CLU_051199_1_0_1"/>
    <dbReference type="OrthoDB" id="18530at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="437" mass="46696" checksum="744AFEDE6D7B1392" modified="2008-04-08" version="1">MGGDSLLIPQQPHVQCPLWQTPNIIPRGKLMRLFGVRSSNMSLSQRQSSHIPFLARFYALIFVALSHVAAAGKSEVASGRAVYSYGQPMPVTCLNRTIDSGEHVMPPHFRCLLAITDNLGKLQYIPFPTCNETFLPLALRYGVTETVNCTISSLPDELYHLLEYYVHSDVPLACRVPTAPLTTSAQAGSSPDAKKSENTDLSPLDNGGPAYTPLTFALQGTLQRSHLHIWTDMNVVVHNIPSASKTKKRNRKSKHASPGYVVAGTAYSIPEFDGLLPKDKDVDEDDAALAISEAARDPWTAGHGTKVIRGEPLTFTFHVSWVEGGKGIWWPAGGLDSAEGSSGVASFFSSFFFFVLAAGVGAVVALYWERNGARRRAGWRGDGILGASAPRGKGSVGIAYSNGGKLNGYGGYSPSSTPSVVAAGGGGYGYGGYGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSI7</accession>
    <name>B0XSI7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_027330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027330"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="PhylomeDB" id="B0XSI7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="68"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="607" mass="66369" checksum="37DFD6DC977D146F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSJ8</accession>
    <name>B0XSJ8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="7">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_027450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="7"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027450"/>
    <dbReference type="HOGENOM" id="CLU_056776_7_3_1"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="PhylomeDB" id="B0XSJ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015964">
        <property type="term" value="P:diadenosine triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="9">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="196" mass="21711" checksum="F0C2AD60A2FBE0A6" modified="2008-04-08" version="1">MSVRDPVPAMSAALKGAQIYFGPFLVTSQVFHLTPLSFALVNLKPILPGHVLVSPRRRVPRVADLTAAETSDLFLTVQRVGRMVERVYGASSLNIAVQDGPEAGQSVAHVHAHIIPRKRADLDHRGGMDAVYDLLDGEEGDLRRAFEEGKEGERRPRAKFPAVDNEGRSPRSMEEMEAEAEMLAREMERMEREVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSS6</accession>
    <name>B0XSS6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_017440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017440"/>
    <dbReference type="HOGENOM" id="CLU_097212_0_0_1"/>
    <dbReference type="OrthoDB" id="4462933at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760442" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="250" mass="27428" checksum="A47A53525E64A18D" modified="2008-04-08" version="1">MGAPNFYRSGLVSLLFVSLCVSSLANADYNRFCPDKTSQIQVDSTFYTVACDTSYISPAPKKVREGALPEDCARLCTAEPACHAIVWHLGNCWQSDKTDAVSFRVPGAVLLTPGEKHDHATGTSEEQKPCLAENVEAANKEIARLSNQQTVTDRFVPTEKDDGLEIVVGGKRWKIYYSKLNDPGAWDVGTLSQPSYMACMELCASKPTCVRTAWVNNYAGANTCWMRSYGQNTVQTITRGWTSTHLIAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTG6</accession>
    <name>B0XTG6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_018510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018510"/>
    <dbReference type="HOGENOM" id="CLU_053714_0_0_1"/>
    <dbReference type="OrthoDB" id="5403157at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="388" mass="42316" checksum="088DCA74325A1E73" modified="2008-04-08" version="1">MWAPLSRVQGQNYPRLGRKRIKSMAASPPSSFSASLSSSSSLYPSSCSSIHSPPLLSTNLSPSSWSPSHRPSAASARHQLESLIAKHGHPIRVSLSSLRDLTATSSTYSPPSPLSPRSPASEISELSDTVILSRSTSRPIPIPKPPSSPYDSDLPVTPLTGRFEKDYFPQSGQSKSWRNRESLSRLDSDRYHRPSYHRPSTRMRSDSSSFYSPVMSPSMSPSTRSASPQPTRSRPHNSAKSVPAFHLGSLPRFHPAVYQPSNNSQSLTAQPPSPRHSRQQSYWTSSGSRDTLRQYGELVESATLSRAPSRPLSPSPSAPRLDPLRSPGPVTPLALEETGGYLTIGATSSDFSSSDSQSSSAAPDLVEKLIAREVERDRQKSRKSSKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUT8</accession>
    <name>B0XUT8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_031390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031390"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="PhylomeDB" id="B0XUT8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF10">
        <property type="entry name" value="CHAIN DEHYDROGENASE_OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="309" mass="33980" checksum="C15F415CD706B62E" modified="2008-04-08" version="1">MSLTLTRSLTAARLRLPYTSLHPCLRLTYSTATNEQHIQRKLPRMRPHRFKEFDLADRVYAVTGGGRGLGLAMAEALMEAGAKVYCLDRLEKPHPEFETAKGQAEKEYGGALDYRRIDVRNEPEVNDVFAEIASRDKRLDGLIAAAGINHLQSALEHSQSALNEVMQINYNGVFNSATAAARQMFNYQQKGSILLVASMSGLIANKGMTSPVYNSSKAAVIQLARSLAMEWGRRGIRVNCLCPGHILTPMVELVFEQNPAAKATWEAENMLGRLACPEEFRGAALFALSDASSFMTGSTMIIDGGHTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUY6</accession>
    <name>B0XUY6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_031880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031880"/>
    <dbReference type="HOGENOM" id="CLU_067096_2_1_1"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="PhylomeDB" id="B0XUY6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP55126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="227" mass="24357" checksum="33DA05C1A715C61A" modified="2008-04-08" version="1">MTLPSNVHVSSHPCLQAKLSQLRSHSTSPRETRSLVHDIATILGVEAFAAGLKAASGGKDKTPLGIEYETTTIDPANVALVPILRSGLGMIEAINDLLPTTVPIYHLGLFRDKFTLQPVEYYNNLPFLRPDSPTNSTAATLAILLDPIIATGATAEAAIQLLREWGVQRVIMLSVLGSKPGLRRAAECWPEGVEVWVGAVDEQCDERGMIVPGVGDIGDRLFLAIGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV83</accession>
    <name>CYNS_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyanate hydratase</fullName>
            <shortName evidence="1">Cyanase</shortName>
            <ecNumber evidence="1">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cyn1</name>
        <name type="ORF">AFUB_032210</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="1"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV83"/>
    <dbReference type="SMR" id="B0XV83"/>
    <dbReference type="EnsemblFungi" id="EDP55158">
        <property type="protein sequence ID" value="EDP55158"/>
        <property type="gene ID" value="AFUB_032210"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032210"/>
    <dbReference type="HOGENOM" id="CLU_103452_0_0_1"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="PhylomeDB" id="B0XV83"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000403242" description="Cyanate hydratase">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <sequence length="154" mass="17076" checksum="DEA94C471BD2111A" modified="2008-04-08" version="1">MSLATLDATQHPNLPASAATLFKAKAQKKLSFEQIAQHIGRNEVATAALFYGQAKASPEDIQKLSELLNISPQVLEEQLSGFPDRGRSVEMPPKEPLIYRLYEIVQNYGYAYKAVLNEKFGDGIMSAISFSTKVEKETDADGNNWAVITLRGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVB7</accession>
    <name>B0XVB7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L37a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_032560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032560"/>
    <dbReference type="HOGENOM" id="CLU_141199_1_0_1"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="PhylomeDB" id="B0XVB7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="92" mass="10156" checksum="1802BB96CCD4DC65" modified="2008-04-08" version="1">MTKRTKKVGITGKYGTRYGASLRKQVKKMEITQHARYVCTFCGKNTVKRQAVGIWECKGCKKTVAGGAYTVSTPAAAATRSTIRRLREIAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVE8</accession>
    <name>B0XVE8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeats protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_022000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022000"/>
    <dbReference type="HOGENOM" id="CLU_008722_0_0_1"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="PhylomeDB" id="B0XVE8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="576"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="674" mass="76441" checksum="4B0FE533034B5623" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVM6</accession>
    <name>B0XVM6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_032980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032980"/>
    <dbReference type="HOGENOM" id="CLU_022549_3_1_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="PhylomeDB" id="B0XVM6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000039">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="179"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP55234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="453" mass="51977" checksum="502CCB0B2558AEE9" modified="2008-04-08" version="1">MKPLELKLKPELRRFAPMALAAVLFFCTLVLFYEMMPALHGTIAKPTSSSHGTNPGPSGGSSDDFQHTDRRCHAVPDPGNILFIVKTGATEIYEKLPTQLLTTLGCARDFLIFSDLEEQIGPYHIFDALADFNASMKATHADFELYRQQQAYQRGGLDIATLKNDGKAAWTLDKYKFLHMVEKTWAQRPHMDWYVFIESDTYVVWTNLVLWLRQFSPKDKLYMGSASFIGDQGFGHGGSGYVISRALMEAFVGKEQRMADRYDDVIPNECCGDFVLGRTIKQELGVGIRNFWPQVNGEKPATLEFGSKQWCQPVVTMHHVMPRERSAIFDFEQARDDVAVCYAPLIFRELSELSFPTGRMRVQEDDWDNLADVPVALDNPSMEACRDQCLSQDTCFQWRYSKDECHVSTQSFKIGTKRLPEYHRRWFSGWNVARIQKWRDEHPCEKPAWVKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVQ1</accession>
    <name>B0XVQ1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pigment biosynthesis protein Ayg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_033240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033240"/>
    <dbReference type="HOGENOM" id="CLU_053723_1_0_1"/>
    <dbReference type="OrthoDB" id="5409895at2759"/>
    <dbReference type="PhylomeDB" id="B0XVQ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000145">
        <property type="entry name" value="Pigment biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="406" mass="45284" checksum="0D9074285F1B2330" modified="2008-04-08" version="1">MPRWILGDKFDTVFPHKGSLKVLWESRWKFACSKSVYPFHDGSIEDFEPIFNHLISKNINDAASDEYTQAFLPTASALEEKAAQALQAGKHEEASNLLCRAAVVYRISRFPYVDITKPNSIKRVAFERQKQAYLKATSLWTQPIREVAVPHTYRTGNDGAHIPIYIRTPAGADQSNPVPIVLIMTGLDGYRPDNSQRTHEILARGWAAVVAEIPGTADCPADPADPASPDRLWDSVLSYLDQRPELNTAKMVVWGLSAGGYYAIRAAHTHRDRLLGAIAHGPGCHYYLDPEWLAKVNDHEYPFEITAAWATKHGYKTVEEFVAGAQKKFSLVETGIVDQPSCRLLLLNGVDDGVVPIEDCLVLFEHGSPKEGRFYKGLPHMGYPNSLPVSYEWLEQVLASPSKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW85</accession>
    <name>B0XW85_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myo-inositol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_023930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023930"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="PhylomeDB" id="B0XW85"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="57360" checksum="3B2685517A9F686F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW87</accession>
    <name>B0XW87_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_023950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW87"/>
    <dbReference type="SMR" id="B0XW87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023950"/>
    <dbReference type="HOGENOM" id="CLU_2171717_0_0_1"/>
    <dbReference type="OrthoDB" id="5415741at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="112" mass="11884" checksum="F2284F1FEEE0F654" modified="2008-04-08" version="1">MGFHPIELRIQILGLSAFGVDSKEIAAALDVPVRSVQRIIQRAKERGFDPATDPRVKMEYVEDAERSGRPKKGSKVMAAKSQAGSTSGSESVVAAGSEVGDGNRNSMPEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWE1</accession>
    <name>B0XWE1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nuclear pore complex protein An-Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_024490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWE1"/>
    <dbReference type="HOGENOM" id="CLU_009483_0_0_1"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="PhylomeDB" id="B0XWE1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="752"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP54393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="98372" checksum="8C746A56529ABF29" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWJ2</accession>
    <name>B0XWJ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_036110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036110"/>
    <dbReference type="HOGENOM" id="CLU_031806_2_0_1"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="PhylomeDB" id="B0XWJ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="363" mass="40198" checksum="BF52406033C43834" modified="2008-04-08" version="1">MQRFSYLQNLRRPSQADKPHDPVLTTEDEQFLQSVTAQPPEAEATLSLNGDENVRPSVDASSTEAFNIPLPTSPVEEFKQLGEEERKASNAGVVRTDSKLSHVESTSPSDKKKGLWSWLRRRGTSWKKKDKEPTAPAEPNVSQSLQSSDPAKSEAKQETDEMTEILERLNLAADNNCVFSISDETQELLRKFTLIFKDLINGVPTAYHDLEMLLSNGNKQLQQTYSQLPGFLQKLVEKLPERWTETLAPEVLAAASERASRSGLNVENVGKAAAAANKMGIKVPSLKELVGKPAAIVGMLRSIMAFLRARFPAVLGMNVLWSLALFSRYLLLKLANWHTNGECFTQSSYSSFGTVINAAVKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWK0</accession>
    <name>B0XWK0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial chaperone BCS1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_036190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036190"/>
    <dbReference type="HOGENOM" id="CLU_010189_6_2_1"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="PhylomeDB" id="B0XWK0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="56"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="280"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP52453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="499" mass="55908" checksum="FF7112B7C34A9384" modified="2008-04-08" version="1">MERNGAPDTAGLPSPGDLVLRQRNDAIQAAIQQPSDGGLFSQLSSNPFFTAGFGLAGLGAGLSLAQKGVRHGAALLRRRMLVDVEISIKDDSYPWFLHWMTLYQQSQLNAARSAASRSGFMETILQKLTPGMRHLSIQTQKVEHANGAIHTHFALVPGPGRHVLRYKNAFIFVNRMRESKSQDLQTGRPWETITLTTLYSHRHIFEDLFKEAHAYAAKSHEGKTSIYNSWGTEWRLFGQPRRKRPLDSVILDEGVKERIVEDVKDFVSSAKWYHDRGIPYRRGYLLYGPPGTGKSSFIQALAGELDYDIAILNLSERGLTDDRLNHLLTIVPNRTLVLLEDVDAAFSNRRQTDTDGYRGANVTFSGLLNALDGVASAEERIIFLTTNHVERLDEALIRPGRVDMTVRLGEVTRYQVRCLWDRFYGDLDTTGFYRQAFLDRLQELGLIEDEKGFKADRSRSTSAAALQGLFLYNKGNMEGAVAMAEALTHTVHDSAEGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWV4</accession>
    <name>B0XWV4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome b561, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_036540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036540"/>
    <dbReference type="HOGENOM" id="CLU_090067_1_0_1"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="PhylomeDB" id="B0XWV4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="37"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP52488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="238" mass="25518" checksum="3B752358878E8102" modified="2008-04-08" version="1">MASATGVPQEHPQTIEAREDEPLLGAAECEVVWLDTDSSAAGTAAIAQCGILLLTALVWAGVFSHPLIFFSAHPLLNSSAILLQVQAALILQPTATPQQKLLGTQIHYSLQAISLAAFLTAFTIIEINKGDHPRLTSLHGILGLITYICIILQALLGLVQYFFPVKILGSADAGKRLYKYHRHFGYLLLVLELATVSAATQTTYNVAVLHIPLWGVLVAAVLIVAGVGARIKKHKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX90</accession>
    <name>B0XX90_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator PAB1642, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_037230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037230"/>
    <dbReference type="HOGENOM" id="CLU_055855_0_1_1"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="PhylomeDB" id="B0XX90"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="303" mass="34293" checksum="007F92599A59F3E0" modified="2008-04-08" version="1">MTTPLTFQLLNISTCPISSATTHPFLQQAGCGQISKPLLSQWLSQDRLYAQSYIRFIGLLLSKIRLPPHNPDSSKPRTSTVEYRAMEVLVDALVNIRRELQFFEETADEYGLDLTALPAAMEDEERERGECVRGEVQAEELFFGPNRITQAYIDMFMSAGSAATSLLEGMVVLWATEACYLQAWRYAASCGASRKATAGPEQDADGGALRTRFIPNWTSPEFEAFVQRIGDVVDELAGQIKGAEEREELMGRCVQWWRQVVWLEERFWPVVKNKIKANIITVRPNHRVVQRPEPPHPRTPCMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXQ3</accession>
    <name>B0XXQ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Telomere and ribosome associated protein Stm1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_038210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038210"/>
    <dbReference type="HOGENOM" id="CLU_043312_1_0_1"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="PhylomeDB" id="B0XXQ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="133"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="331" mass="36892" checksum="1507381C03EA4EC1" modified="2008-04-08" version="1">MADVRSKKRETNWGGVRFELSIDSAGQKKRSKQHNLYELLGNDPELDPNREPEPPTRAVDRPAPRHGKRDAPKEPATKPNLHENNARRGSRFTGNEAAFRDRQAGSRNNREKPLDEGKEPQRRAFHARGDRGERYRNDRQSRTGQVDTRKQVNQGWGAQTGDKAGDKAWDDERAAENLAQNESEPQTPANEEPAEPAEKTKTYAEYLAEKAAQGDLAAKPIRAPNEGSNLDKKWANAKELKRTPEEEEAYIKGKEEKAKREKQRKEKNVLEVDMRFVESPRGGSAGRGRGGRGGRGGRGGRGNGAPRGEQQQRGAPPVTVDEKNFPSLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXR6</accession>
    <name>B0XXR6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_048590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048590"/>
    <dbReference type="HOGENOM" id="CLU_1041983_0_0_1"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="267" mass="28194" checksum="29755640ED5CA6E5" modified="2008-04-08" version="1">MSAGVTVPLGARPSTGAGLWLQGGIGHLTRLYGLVCNAVVGVVAASVSTGQVLCIGTVPNEHCPVDAVRPENQTELLWAVRGAGTNIGIIISVTFKAVTAPTYLVRTWVLPLSDDLDGQLQLGNFDQSLASRLPANCCADAYLYWEDGRTHLGVTLFECFTPADGLEPLSRLSLPMGAVVGSEHSSKTMDGVEVFDADMYMSGMYGGHSGSKTSSFKRLRAIRTQPSPLCYLHFLHGGGAVDSVAIDASAFGCRGWDFACIVTGVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY20</accession>
    <name>B0XY20_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_039350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039350"/>
    <dbReference type="HOGENOM" id="CLU_008830_0_0_1"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="PhylomeDB" id="B0XY20"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF127">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="531"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP52766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="637" mass="68679" checksum="35534D2E5C71C7EB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY51</accession>
    <name>B0XY51_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_039660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039660"/>
    <dbReference type="HOGENOM" id="CLU_010194_8_1_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="B0XY51"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="382" mass="40719" checksum="D17337E385417811" modified="2008-04-08" version="1">MDPSQFATSNRGKVAVVTGAGRGATLALIDVDVEALETTKAAAHNVQDRQSHVETYGLDITDPGAVQSTFKSIAATLGRVDILVNNAGITRLHLFAEEEGFDDFWRTVEVNFKGTMLCIHAVLPGMVEQKSGCIINMASRAATVDGPKSVGYNASKAALVRATGSLQEDLASMGLGEQVHTYCLHPGSVWGDILTGNTTAEQQEQLPPIFKDVPELAAGTVAYLSTGRGKALRGLYFDCRQDIERVASFGRETLQRAGLYSLATRFSCLDMRMNPDLSSAGRLLLYYSTLLLYYQLWSLDKSLPPAAGDDLPETPPTPEDARNAGHGSLGGEPTPTGPTSIRCAPSPAAPLELPDMSPQWVSGSREDWSPAGQQDGGSFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY52</accession>
    <name>B0XY52_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol oxidase vanillyl-alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_039670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039670"/>
    <dbReference type="HOGENOM" id="CLU_024402_0_1_1"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="PhylomeDB" id="B0XY52"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="412" mass="45974" checksum="AC93A0E1AF01AAE6" modified="2008-04-08" version="1">MSLQRSSVMITSKSTTNRLMMAAPNTHDGMAATDEEELVASAVVYPGSTEEVQKIVHWANKHVIPLHPISMGRNFGYGGAAPWVRGAVVVDLGKRMNRILDINPEDCTCLVEPGVSYYALYEEIQRRGYKHLWIDVPDLGGGSVLGNALDHGVGYTPYGDHWAMHSGLEVVTPTGEVVRTGMGALPGNNTWQVFPYGFGPVIEHVWPRDSDILLNMGCSDVSSSGKKRIWSSWWRSIVRPLRIAIILDNAANIRHALQVLALSGAPRTAFYQGEGPFPPEKMSEYLRDHPYGDCTWLYFGTCYGPSEVRKWKLEPIHREFMKVPVARRIDPATLPPSDYFWSRDRTSSGEPDLEELAWVNWWPNGGHIAFSPVAPTRGADALRLWQLAKKHWAASGLDFFPSTLWLGFANCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY73</accession>
    <name>B0XY73_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAIB/BAIF family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_039880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039880"/>
    <dbReference type="HOGENOM" id="CLU_021588_0_0_1"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="PhylomeDB" id="B0XY73"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF4">
        <property type="entry name" value="BLR3030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="494" mass="52655" checksum="40BFB4F63C9BA40D" modified="2008-04-08" version="1">MASAQSESQSVPDRTSFTARDSVEYIWKHLGLPAESLDALDLKGSGPGLPSSFKIADLAQASVGLSALLAAQIYALRTASPVPTVTVPRQHAIIEFKSERLYTLAGQPAQNLWGPLSGLHKTSDGHVRVHDGFPNHSNGAKAVLRCPPSADRAAVSSAIAPWRSVDLETAAFDAGCVISALRSYAQWDATPQARAVADLPILLRRIGDAPPGLPPSMRSAPTDKCLRGLRVLELSRVIATPLSGKTLAAHGADVLWVTSPNLPDLPPIDREFGRGKRTIQIDLDAAEGEAELWRLIDDAHVFVQGFRPGALAARGFSPETLAARAAAQGRGIVCTNLSAYGPTGPWRARRGFDSLVQTCSGMNVSEAEHYGAGEAGRAAPCQVLDHAAGYFLAAGVEAAVYRQATEGGSWVVDVSLAGVMKYLRSLGQYEGRTGFDEGRDYVSLADVPEGYLETRQTGFGEMTFVRHSAAVEGVEVGWDVMPKPLGSDEKRWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZI5</accession>
    <name>B0XZI5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_033990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033990"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="PhylomeDB" id="B0XZI5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="578" mass="62418" checksum="FE81FC785BAEF08E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZT2</accession>
    <name>B0XZT2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_034280</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034280"/>
    <dbReference type="HOGENOM" id="CLU_031740_3_1_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11020">
        <property type="entry name" value="CuRO_1_CuNIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04208">
        <property type="entry name" value="CuRO_2_CuNIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000093">
        <property type="entry name" value="Copper-containing nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02376">
        <property type="entry name" value="Cu_nitrite_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0186">Copper</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="133"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="296"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="11">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP52264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="423" mass="46332" checksum="66DCF1EBA9E08BA1" modified="2008-04-08" version="1">MSKYVLFGRPWPRRGPPWQRLSLPRRSPALIKPLSTGTTPKPTSSRPNGRLQVWPWLAGPILGVSLFLSAHRRPMQLETDTGLQRGNLTRDESQDDIDLPKEDAILTTAPNVPPPITRTRPVLLHVPLTTATKTRQLTSQYKYDTWTFNDTVPGPFIRARVGDVVELTLTNHDLSGNPHNIDCHAFTGPGGGAAVTTAEEHETKTARFKLLYPGLFVYHCAAAPVPVHIANGMYGLIYVQPEDGDALSPVDREYYVMQSEFYHEPPEIEDNGRPSSTVEFSYPAALREEPSAVVFNGSESALTRDRPLKAKTGESVRIFFGNAGPNLTSSFHVIGSHFQHVFRDGGVVDPPARVLSTVGVPPGGAAIVDLKMIVPGTYTLVDHAIFRMDKGAVGYLNVAGAPRPDILYSQMPPEPCVGCKLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0S5</accession>
    <name>B0Y0S5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Topisomerase II associated protein (Pat1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_058370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP51816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0S5"/>
    <dbReference type="HOGENOM" id="CLU_012622_1_0_1"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0S5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="824"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="827" mass="91773" checksum="9951773A4982CC4D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0Y8</accession>
    <name>B0Y0Y8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ser/arg-related nuclear matrix protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_058990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058990"/>
    <dbReference type="HOGENOM" id="CLU_012506_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001699">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="61"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="85865" checksum="BAB402158118CCD3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y105</accession>
    <name>B0Y105_ASPFC</name>
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        <submittedName>
            <fullName evidence="8">Cyclin dependent kinase (Pho85), putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">AFUB_059160</name>
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    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    <dbReference type="PhylomeDB" id="B0Y105"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08606">
        <property type="entry name" value="GDPD_YPL110cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000570">
        <property type="entry name" value="Glycerophosphocholine phosphodiesterase Gde1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="814"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="896"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1199" mass="132267" checksum="D9C6035CD56D4BA5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y114</accession>
    <name>B0Y114_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_059250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y114"/>
    <dbReference type="HOGENOM" id="CLU_018876_0_0_1"/>
    <dbReference type="OrthoDB" id="2364732at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="499" mass="57038" checksum="88238EE791AEDCDD" modified="2008-04-08" version="1">MEILASAGKSNQTQQDFWKRRCFYSRPGSRWSVSMARTLDGMLLQQRYPESSVTDFFASNTVILVDEAQASYKDSYFWNTIIKERRSGEGMGIKICLFCSYGSPLTGLEGDHVWFTPATFGPAQRITLTPQPGKDSPKLGLFYTPDEFDEAVSLLTTNKYDEKFTIDEEAMSYLYELTNGHPGGVTSLVDYLHSVHRHDLKHRRMSTITKDHVLDDLKDDTRVFQFLMNQAVFRSFPVGGRLTPNVAGILSKILEEGNMPFDSDDVDFQTCYERGWVHRISVGEIYACDVAVMPSRLHEKWLEYIIGQNPRPLPAKFSQLDKLCLEVLSNFSTMNLRHAVQGKKMSTAAKCRPVEAQYQDEFYRSFNLLAGRGVPICSEWSRTGDGRVDFYIPEKKWAIELLRDHDRVSEHISRFKEGGKYYSWLKENMVEDWIIINCASSPPISGMFILCIAVIPTHLAHNLIEYSEPRLWTAVFANDYSELKPIRVPLGLHYDETGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y139</accession>
    <name>B0Y139_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tubulin-specific chaperone D, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_059510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y139"/>
    <dbReference type="HOGENOM" id="CLU_003043_3_0_1"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="PhylomeDB" id="B0Y139"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="380"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="473"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP51930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1201" mass="133186" checksum="C5B20FD70A92CAC7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y195</accession>
    <name>B0Y195_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-galactosidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_049140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y195"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049140"/>
    <dbReference type="HOGENOM" id="CLU_027430_0_0_1"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.20:FF:000001">
        <property type="entry name" value="Beta-galactosidase, putative (AFU_orthologue AFUA_5G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000135">
        <property type="entry name" value="Beta-galactosidase, putative, bgl35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.20">
        <property type="entry name" value="putative beta-Galactosidase from caulobacter crescentus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040719">
        <property type="entry name" value="DUF5597"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18120">
        <property type="entry name" value="DUF5597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 42 N-terminal" evidence="4">
        <location>
            <begin position="48"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5597" evidence="5">
        <location>
            <begin position="396"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="565" mass="63178" checksum="0C677D65474FE006" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1M3</accession>
    <name>B0Y1M3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_049810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1M3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049810"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1M3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF33">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="277" mass="31064" checksum="594BCCDB457E0E5E" modified="2008-04-08" version="1">MAFKLYHYDPSAGAAVSFAAVFGLTTVVHIWQMAKTRAWFMTAFIIGGFFEAIGYLCRYISAKQTPNWTTKPYIGQSLLLLLAPALFAASVYMILGRIIRLLNAGSLSLVRPNWLTKVFVAGDVISFFMQCGGGGLLAGAKTQDKVNMGEHMIIAGLFVQILFFGFFMLVSVIFHRRMLATPIHHMMSTQLPWNYYMKILYTVSVLIMIRSVYRVAEYVQGSDGYLQSKEAFIYVFDAALMFACCVILNVSHPSKLLSHSQADQKVDSDLEMLNPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1Q6</accession>
    <name>B0Y1Q6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_060450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1Q6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060450"/>
    <dbReference type="HOGENOM" id="CLU_030461_1_1_1"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1Q6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="332" mass="35803" checksum="38AE5F56675E3AFD" modified="2008-04-08" version="1">MAATQVTGKWTKILDAEILQRSSQVLAVVDNVAHVFGGELRPREPRDNDVHTIALDSTNSISTIAKPSTSQVPAPRVGSASTTLDKKIYLFSGRGGLAMSPIDEAGAVWEFTPQTSSWRLITPTSEIHPPPRSYHCMTSDGIDTLYLHAGCPETGRLSDLWAFRLSTREWTPLAAAPDPPRGGTSIAFADGALYRMNGFDGKMEQGGSVDVYSPGENVWSSYGFVADGVSGPEARSVSALLPVRTGEKVALVTLFGERDPSALGHQGAGKMLDDVWVFDVQERSWRRVDAQGEAPCARGWFAADVLGENAIVVQGGLDESNRRLGDVWILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1R9</accession>
    <name>B0Y1R9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GATA transcription factor (Ams2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_060620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060620"/>
    <dbReference type="HOGENOM" id="CLU_001743_0_0_1"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1R9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000067">
        <property type="entry name" value="GATA transcription factor (Ams2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1174" mass="128154" checksum="83D18807F2E68F04" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y318</accession>
    <name>B0Y318_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_052630</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y318"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052630"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="PhylomeDB" id="B0Y318"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990860">
        <property type="term" value="C:Pho85-Pho80 CDK-cyclin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050849">
        <property type="term" value="P:negative regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071073">
        <property type="term" value="P:positive regulation of phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046822">
        <property type="term" value="P:regulation of nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07836">
        <property type="entry name" value="STKc_Pho85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="72"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP51259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="389" mass="44344" checksum="FC7C65E2FBABFFF7" modified="2008-04-08" version="1">MDYRNSYRTAEDSRSEYNNPASFSEIVSTLVSPKSFLFNNQRPKPSTQQTSITTRGNISSQTMDKSQQPSSFQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLDSEEGTPSTAIREISLMKELKHESIVSLYDVIHTENKLMLVFEYMDKDLKKYMDTRGDRGQLDHATIKSFMHQLLKGIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAELYTGRPLFPGTTNEDQLQKIFRLMGTPSERSWPGISQLPEYKPNFHVYATQDLGLILPQIDPLGLDLLNRMLQLRPEMRISAADALQHPWFHDLPQLQAQLQQQQQQQQQQMAGGYGGMVPPQQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3C4</accession>
    <name>B0Y3C4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_053710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3C4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053710"/>
    <dbReference type="HOGENOM" id="CLU_1660315_0_0_1"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="159" mass="17546" checksum="81EB03AB00E5EC3E" modified="2008-04-08" version="1">MPGPGKVIVPLPEQNYNTNKYVRYSVVISAFAIVILSVLGSLYKSEHHGFVGSENDPEDGGAVAASIFTAVVIYAVSLSHHHPARLVWSRCADTLSSVVLLRFLCLPGLLAHEKPPGRCYIAKLDNFLYIPRKKTWNSPFDLCPSYETNGYVKCIRGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3F3</accession>
    <name>B0Y3F3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_054000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3F3"/>
    <dbReference type="HOGENOM" id="CLU_014025_0_0_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3F3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="696" mass="79215" checksum="171E62898C05AADB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3J7</accession>
    <name>B0Y3J7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_054440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3J7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054440"/>
    <dbReference type="HOGENOM" id="CLU_049464_0_0_1"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="448" mass="51080" checksum="AC5651F73E72CC6D" modified="2008-04-08" version="1">MSAKVLIPNKQRVIRPRTRKARNNRRHRRKQRVIWTLLRACLHSLVMGHTKLEPLSPRFLYLCFIDGNSASAGVRSRQRWGTERRLRTPRRTASRICTWRSLREAAWRVRLPETRRLNIINPNPLCYIEKYPQFDTSLIWQFNYNLSEVDEEVGHTIAHFLCTGSYETLRTTSDSGLSNVAIEYRRSMLVYHAARKYDLYDLEVYAKKYIQMFGQSMSAFDSMEAARKIYSKLPRDEAWLPSYLHERLRLAFLMDANIFQGDEFYDGVGKDPDFDKAVMRMVVNIYSEALSKQGTAAVLEETVAEEGVAEEDSSAPPVAEEDLTEPPFAEEAFAEEAFAEPPVAEVVEDAASFSLPAEPSRITLDLGWGKVRDTGSKTGLRFLDAGNGHMEKDTNGWHSNNEAGESVGFSVPPKEVKSGKKNGKVKKTKKSNKKEQLAEPVRTSSDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3R5</accession>
    <name>B0Y3R5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab small monomeric GTPase Rab7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_055140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055140"/>
    <dbReference type="HOGENOM" id="CLU_025224_1_1_1"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3R5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000132">
        <property type="entry name" value="Inositol 5-phosphatase, putative (AFU_orthologue AFUA_5G07600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="51523" checksum="0C75023B94448101" modified="2008-04-08" version="1">MDNLTLYILTFNCARNPVDIDLFASHFFHALPHTVPSAPHLIALSLQELAPIAYAFLGGSYLTPYFTSFRQVVARAAASRWEDVQYATVVEDHVGMTGLMVFARSDVVGRIASVQTAGVGLGLQQMGNKGAVGARLGWMLESESESETVLVPLTFVSAHLAPAEDAFERRNEDWRAIVERRRTRRRRRRXXXXXXXXEDEEEEEEEEERAALLGSSRATGESDGEGVFTGGYLFLAGDLNYRTSNTLPQPADIARFPGLEADESDPLHYSRLLREDQLTREREKRRCFHGLSEAPIGFPPSYKYELGARDPRDWKFVHSRWPSWCDRILYLESSTATVTPYRYDALPLFPTSDHRAVALAAAVVLRSIQAGPSDSESAPATDMQQQQPQPQPQPQPAPAPAAPFPIDRDWKRKRDEARRKELVVGGLAYLGLTWEGRRYLVGMVIGGLGAWFILRSMLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y410</accession>
    <name>B0Y410_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha-1,6-mannosyltransferase subunit (Och1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_056120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y410"/>
    <dbReference type="HOGENOM" id="CLU_022381_5_1_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="PhylomeDB" id="B0Y410"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760695" evidence="12">
        <location>
            <begin position="27"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP51601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="425" mass="47853" checksum="BC2AD5CD1A222233" modified="2008-04-08" version="1">MLTFRKSLIAAVVLITFVVLLRSAHSSPSAEPAVLNTETTAHDTSQAADEHLTDQKQDIQQQPLKPPPTAPLRERLRYQFPYDLENRFPAYIWQTWKYTPASMWFSEDLRPAEASWTELHPGFVHEVIPDDTQRHLVKYLYGSVPEVFEAYDSMPLPVLKADFFRYLILLARGGIYSDIDTYALKPAVDWLPGELDLATVGFVIGIEADPDRPDWHDWYSRRIQFCQWTIQAKPGHPILRDIVAYITEEALRMKKKGILKEGKMDKTIVEFTGPAAWTDAVFRYFNNPEYFSIEPGSTHNVTYEDFTNQRGYKKVGDVVVLPITSFSPGVGQMGAGDLDDPMAFVKHDFSGTIMEDRSGSLNVDCMASSCHWLQPPLPETCQACGQADLDPGSLARANLALKRQDPYLPCAGPGVTSIPTKDQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4C8</accession>
    <name>B0Y4C8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_057300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4C8"/>
    <dbReference type="HOGENOM" id="CLU_024508_3_2_1"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4C8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="591" mass="63505" checksum="76CDBB64290D266E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y543</accession>
    <name>B0Y543_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_071330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y543"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071330"/>
    <dbReference type="HOGENOM" id="CLU_685076_0_0_1"/>
    <dbReference type="OrthoDB" id="4710131at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760715" description="Integral membrane protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44362" checksum="D5AC515BF4DC829A" modified="2008-04-08" version="1">MRLPLFSFIYVAIFASIVSATGCSKCLNQNADNIRLGCFNKCGEAFNPSSSEYHACRDQCTEFVFQDHCCTSSCSSKSKVCLNDYFHRVGLTKRDSVDEEAHYLAQLDAIRANPDLLDKRALLVGDAPYHLIRSTEDLRSLNHPDFTNTIVYDVFGHTGAGALDRRIDYGKTCCLAAGAVLQKGMAEIGLGWTSNEWTDDQRQGLVLVSFGVAAAYACNLVYNVQCLMFNARPAGVELISSTALLSKHLAFTMEQESSTPLYLRRALAIGLALTALRQLKSLRLSYLFPFSNPVTDEVDKMFAFAVNTSTLFFTWCIAEPSIAQPLPITNLNALRSTLAGIILTLTVCGDSPLKRLLAGLAIGACWMLGWAITSADQRAAYWRFMRDGLGFTLINLWRRAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5A9</accession>
    <name>B0Y5A9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_071980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071980"/>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_1"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5A9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415:SF3">
        <property type="entry name" value="GNAT-FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415">
        <property type="entry name" value="SPERMIDINE N(1)-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="197" mass="22393" checksum="21A91232925D1442" modified="2008-04-08" version="1">MDPFPPEPYRSARLLYRAPEDNPADDAFFHALYADPVVGSMATTALLRPLSTKERKELRAKLSDVFMSVMICIIPDEGSDKEPETIGVVSLKKEASDFAHNRTYELGISIARQNQDKGYGSEAISWMLDWAFLTAGLHRVELVVAEWNERAQKVYRRLGFASEGRKRQCLWKAGRWWDLLFMGILAHEWEAKKAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y625</accession>
    <name>B0Y625_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_065420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y625"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065420"/>
    <dbReference type="HOGENOM" id="CLU_2196355_0_0_1"/>
    <dbReference type="OrthoDB" id="3553614at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758664" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="108" mass="11645" checksum="E1B0E651A41D809E" modified="2008-04-08" version="1">MQFSLLNFVALLAATSVNATVYLGLRTNYDGHKSQVACGFSTIVDSDSNPCGRNFYVDGNNGPFRFEGCGGNGLTLFRNGQFNSNCKFQSRTINCNGGAKIAQAWVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y687</accession>
    <name>B0Y687_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_066050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y687"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066050"/>
    <dbReference type="HOGENOM" id="CLU_065203_0_0_1"/>
    <dbReference type="OrthoDB" id="5223508at2759"/>
    <dbReference type="PhylomeDB" id="B0Y687"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="287" mass="33379" checksum="93D129FA7E23E344" modified="2008-04-08" version="1">MSLFRNYRAATAQVRSFSSSTCRRVGPESPNFVDVPQTIQPDLRVKPRVKGTLPVPRELFPARRVDKPSEEYIAAATPLPSKDIKIDPNDPHAEYKDWKRRMADMRRQNLREGLLELHSRKQRTDKLMAYRSIQRQRRREQVLRQPERDDERLTRPSIVQEMLPKRTPVLPDPDREERLAQARAKLESKKVRDELERQDSLQTLYMNARTFITTEAQLAAEIEKVFPDGENEAWRSDHQQGENIWNLGVPPTVQNIVNDSKKSEAARWDLIQGRVKKLGEQITGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6N5</accession>
    <name>B0Y6N5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_067580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6N5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067580"/>
    <dbReference type="HOGENOM" id="CLU_131047_0_2_1"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6N5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="94" mass="10778" checksum="349795702D252F9F" modified="2008-04-08" version="1">MSYFRVTLLRSAIGLPRRTTDVLKALGLKKRMATVFHPVSPSVAGQIMKVKELVEVQEVDRRLTKEEVRAERRPDPGYYIEKASIEEFSENRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y739</accession>
    <name>B0Y739_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_072460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y739"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072460"/>
    <dbReference type="HOGENOM" id="CLU_064225_0_0_1"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="304" mass="33587" checksum="02B79DD0DF9FA5C2" modified="2008-04-08" version="1">MSDVKIAGNIVWDPNACPQSKNASSDSAMHDPLPPFALLVTDEEREGKAETSRPGTYHVIVIPESFTHLPEYIENAAEEELGDTIPSPLCGNIETAQLTNNLGLGDSNVVILRQFKDSKRSSSSQCPSASHSPTSDLRESSLSAVTIDATSQNAADDYPILDMLEQESLEAILLSHFRDVVWMQLVPARGIFNFAGENALDVDVFDREATNFPPLFHAMMAISALSLDRKSGSHSIDALHYYHQAFLTLQNNIWSEKDLLLDGLFLTHFLLLVYEVVYGLTIFPDYSTYRLCGTQRSGPSHTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y796</accession>
    <name>B0Y796_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_073040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y796"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073040"/>
    <dbReference type="HOGENOM" id="CLU_015210_1_1_1"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="PhylomeDB" id="B0Y796"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120513">
        <property type="term" value="C:2-(3-amino-3-carboxypropyl)histidine synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="565" mass="62066" checksum="AC651FFA7B526E4B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8C5</accession>
    <name>B0Y8C5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_076860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8C5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076860"/>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8C5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="301" mass="32484" checksum="6CEB847635B7FC44" modified="2008-04-08" version="1">MDTAPRYNFKDINVHDLEAATLFEVRGYVAVVTGAGNGVGLMAAQTLAANGARVYIIGTREEILDTIGEKYSFKGQITPCVLSHSIPSSTAPTDEDGIRGIAAELTKAESKGINILINSASVTSEPRAKSTSSDTDFTDPDAVSRWMTCDGADAWRIAYAGNVWSHHFLTAALLPLLVKGAKAAPGHSSVVLNFAYSSSKAALIHLTREWAHTFLPLGVRVNCIAPSVFPNEISVGRFDEDRRSRQEEELWRKIPAGRVGRETDIGSVVLYLCSKAGTYVNGQIVNVDGGEYHFVPSIRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8G4</accession>
    <name>B0Y8G4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_077250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077250"/>
    <dbReference type="HOGENOM" id="CLU_015502_1_1_1"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8G4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="625" mass="68667" checksum="231251083CD41D39" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8I0</accession>
    <name>B0Y8I0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box and WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_077410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8I0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077410"/>
    <dbReference type="HOGENOM" id="CLU_009186_0_0_1"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8I0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001573">
        <property type="entry name" value="F-box and WD domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="943"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1069" mass="115951" checksum="B1540721E029C54D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8R8</accession>
    <name>B0Y8R8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_078310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8R8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078310"/>
    <dbReference type="HOGENOM" id="CLU_057411_1_0_1"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8R8"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048674">
        <property type="entry name" value="COQ9_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21392">
        <property type="entry name" value="COQ9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Ubiquinone biosynthesis protein COQ9 HTH" evidence="10">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="201"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="299" mass="33550" checksum="7B27C219805446B8" modified="2008-04-08" version="1">MAQPASLARCSQRQFNTLLLSYTLSSRTNHSSYIALQARRLYRTQRSPRRLIHQQTQLSRPQQCIANRSYHSQYHPELPPHEYTNSQTTILSAALNHVPKHGFTLEALTLGARDAGFLDVSVQLLPRGEFDLVLFWLASRRGLLRGKVENGFFKKIDSQGKVLSVEEKTKLLIMERLRMNAEIKHQWQSALALMSLVGNIPLSLSELHALSSDILDLAGDTSVDASWYTKRLSVSAIYASAEVFMTRDSSPDLSATQAFVDRRIEDNKYIGDKITGIKQCLGFMGSTAIGLGRSWGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8X3</accession>
    <name>B0Y8X3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_078870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8X3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078870"/>
    <dbReference type="HOGENOM" id="CLU_818822_0_0_1"/>
    <dbReference type="OrthoDB" id="10392814at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="305" mass="31777" checksum="A58B714A9FC7A6F3" modified="2008-04-08" version="1">MASKDNIAPQVAPADTASGVAPSGPHPAVSISTTSATMPPVVAHGFTGDVTTGTTASGVPPGVSVSNNSGAAQPGVPPSVPGGMTVGATPFGGPPVPATAPVVATPSRIPGGTTSGATTVGPLNLQTAYVTNDIPFDNEGQFRRPNGAVEYADDSGVDSDDDPEGDQIMKEVGDDDKLKLSEENQKNLLKGIAECSDPDTLVAKLEALLPEGKRMSLQQLQEILLPSRWGPEHQEEALSAQNSTLSSPIRKASANTEQIYRKPLVLGRTLTGSTTMADQMYQHPQSQSRIRSIRKHIRKQLDICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y925</accession>
    <name>B0Y925_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_079390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y925"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079390"/>
    <dbReference type="HOGENOM" id="CLU_2830738_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="66" mass="7203" checksum="C614D326B1B43BD1" modified="2008-04-08" version="1">MVGLITFQSFSDGLVSGKQPDPSGIGDLRGKVEYIWNWRDRAGEPADGNMVHQPRGRLVSGSSRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9E3</accession>
    <name>B0Y9E3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_080730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9E3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080730"/>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9E3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF222">
        <property type="entry name" value="MALTASE MALT (AFU_ORTHOLOGUE AFUA_8G07070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="24"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP48636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="583" mass="67103" checksum="CDBE2C902F8D5FFA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9V3</accession>
    <name>B0Y9V3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_082380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9V3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082380"/>
    <dbReference type="HOGENOM" id="CLU_087332_0_0_1"/>
    <dbReference type="OrthoDB" id="5389892at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9V3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30455" checksum="88632873C8921E66" modified="2008-04-08" version="1">MMSSGDSMYMASYPSRWNQPSHYPVNVDMAMESGSDNPFLRYISPSPTPSLSSSTPTLNTVTLERSPSVPSIYWSGELEHQPVEPRRRRNTYHPTYAQQSTQGNRHRSRYRRGSFLVTPDVIDRLDNAGVFHYHHESPYDAVYAERNHDAKTSPIAALEDSNKEALKATPEDKIADCLNSHRPLDGVAFYPPGTTDREGRTYEYEEGTNMMNDYGNFVRFPGLRFTEEDFRNDPFYNSPLPKPFEIIRRAFNRHCRGWKRNKTT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA61</accession>
    <name>LMBD1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AFUB_083530</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA61"/>
    <dbReference type="SMR" id="B0YA61"/>
    <dbReference type="EnsemblFungi" id="EDP48904">
        <property type="protein sequence ID" value="EDP48904"/>
        <property type="gene ID" value="AFUB_083530"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028341_1_0_1"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="PhylomeDB" id="B0YA61"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0846">Cobalamin</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0458">Lysosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000365823" description="Probable lysosomal cobalamin transporter">
        <location>
            <begin position="1"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="572" mass="64712" checksum="2254E3D5CE15D01F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA83</accession>
    <name>B0YA83_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_083750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083750"/>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="PhylomeDB" id="B0YA83"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034643">
        <property type="term" value="P:establishment of mitochondrion localization, microtubule-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51388"/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="800" mass="89228" checksum="437386DD256813C6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA91</accession>
    <name>B0YA91_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial ornithine carrier protein (AmcA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_083830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:L-arginine biosynthetic process"/>
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    </dbReference>
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        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
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    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="127"/>
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        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="231"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP48934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="324" mass="35250" checksum="2484A16944EA4C55" modified="2008-04-08" version="1">MAAAEHVLAIDNEKSMELPVLPPNQGFEAFKDIIFGSAAGMAGKVIEYPFDTVKVRLQSQPSHIPLRYQGPLDCFRQSIQADGLRGLYRGISAPLAGAAIENSCLFFSYRIIQDILRATCYPTADSMPFSALLFSGAASGSITSLALTPIELIKCKMQVPLEASSSKMPGPLTLIAAIFRQDGILGFWRGQMGTLIRETGGGAAWFGGYEGVSAFFRKYHSTVSPRDSESLPIYQQMIAGAAAGISYNFLFYPADTVKSRMQTEDINSPGNSGHRQTFWSVGRALWKQQGLRALYRGCGITCARSAPSSAFIFTIYEGLRNCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAB8</accession>
    <name>B0YAB8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_084110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAB8"/>
    <dbReference type="HOGENOM" id="CLU_082451_0_0_1"/>
    <dbReference type="OrthoDB" id="3596006at2759"/>
    <dbReference type="PhylomeDB" id="B0YAB8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="235" mass="26156" checksum="530E4480816EFD01" modified="2008-04-08" version="1">MAVIWGLDLHEIQWNKFKGAKMFNRAYHLRRTKMIVYQMAMIFCVISESVGTAALSDYLDQQDAIQQQHPEAKVHNNDFIGAASYNIFVGVSVATIFGAAFFFDLFWPERHESKSVRLAWKISGVVVSVMMLASALTMTIITATHSAQITGTDDDSARKFWAEAAKKPALPIASVVFAWPGWVATVARRLLMQDSTVILFVSHKHDDKLGPKSNYGRETESVPAILETGEKTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAN5</accession>
    <name>B0YAN5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_085280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085280"/>
    <dbReference type="HOGENOM" id="CLU_1179974_0_0_1"/>
    <dbReference type="OrthoDB" id="4502408at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="235" mass="26363" checksum="2E03476CB695D2F6" modified="2008-04-08" version="1">MAEPNEVRNAHLASKSIPQRRKPRKLRHKRPVSHGLDKEIEKEAIVDTPASQRETVIFKTSEDESNFKDALEEDSSVIKAQLQPVPERQRQTNQYKPFRDEEEGDMAEGGGAPATAERQRLRRGRHGDRTLIQSNIIDGAGRTVGESQDLVLNRAEGVVGRVTDTSGRVLSQPSEQSDQPKKEKDEPLKLRLDLNLDLEIQLKAKISGDVTLTLLLVYALSYNEAGNSLQLIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBG0</accession>
    <name>B0YBG0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_092680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092680"/>
    <dbReference type="HOGENOM" id="CLU_010672_2_0_1"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="PhylomeDB" id="B0YBG0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="80968" checksum="3BC4EF3176C18FE0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC03</accession>
    <name>B0YC03_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_088440</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088440"/>
    <dbReference type="HOGENOM" id="CLU_031900_7_0_1"/>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="PhylomeDB" id="B0YC03"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000547">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="365"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="183"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP48134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="417" mass="45053" checksum="222B62A034301982" modified="2008-04-08" version="1">MAHGSEDCASVLEQFVHDVANLPAEINHLMEEIQAKDKIIQDCRATINSRDSSLQKFIKLNGSLTPNPKEEQYSKVILQNLDRAQQLQDEKIQLSEKACILLDRQIKKLDIKIRDLQNDGVLSNDPPLPSLFNNKDQYRDPPKIFFPDATAADTTSSPLQPTSGNTNSLLGISQRLNQSLARSTSSAALATQGAARSSAPATPSGTTHFQHRQRESSAGAVENKRRRLNASLGTLPAASSNLRQSSLGPGTPKGGTPASSRAGSAGPRATGATKKAATKKVAPHQQLKKIKAHGKATKRSSSASGRVKLTGATKKSPSAAGGDEDEDDSLLSSAEASDSNASDTRRMDEDIDEEDEEEEGNEDTKVYCTCRSVSHGDMVACDNDNCPYEWFHWKCVGLTREPVGTWYCPHCKSNLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC30</accession>
    <name>B0YC30_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Streptococcal hemagglutinin protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_088710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC30"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088710"/>
    <dbReference type="HOGENOM" id="CLU_043819_0_0_1"/>
    <dbReference type="OrthoDB" id="5394557at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="377" mass="40386" checksum="8BA117124E6A0A84" modified="2008-04-08" version="1">MAQRSGLVPTNSLGARLGSFSRPSGYDLGTCNPQHPPSRQTFSFDHTANYDNEPTAHNPSSSYMFPSSQQGILPDYCGLAWNSKAWNSNTQVNNAQSGAAFPTQDTENAFASSPYPFLFSGQGTQSTDVPMACTPSDGQGADRTLPKASGRSQLHMGMSSPSATPEAMSGLLLSPEYRYGHHLATRASISSGCLPSMQLGSNRNFNGNSPNQSRKVSQSNAPDIMFDYLPITSVATPSHLGSSTGTALNAFETLDSTDDFRASTEGRSARSFSRDSRRFISMMGCGSDIYGYSSSEKSRNRSETADSGSTATLLNGLPYTRPRHADSRSTISFDLLATDVLPEYRASGELQRTSVSAVNDPGVASEVWHVSDLQTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCP4</accession>
    <name>B0YCP4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_090910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCP4"/>
    <dbReference type="HOGENOM" id="CLU_013869_1_0_1"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="PhylomeDB" id="B0YCP4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="77873" checksum="AC280665E9D77BC0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD11</accession>
    <name>B0YD11_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor TFIIIB component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_093890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093890"/>
    <dbReference type="HOGENOM" id="CLU_022548_1_0_1"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000322">
        <property type="entry name" value="Transcription factor TFIIIB component B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017174">
        <property type="entry name" value="Bdp1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037327">
        <property type="entry name" value="TFIIIB_Bdp1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="425"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="586" mass="63958" checksum="144EDD5CE3B8DDC2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDQ3</accession>
    <name>B0YDQ3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096390"/>
    <dbReference type="HOGENOM" id="CLU_003431_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="B0YDQ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114809" checksum="1F680FC8CCB4CF14" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDT7</accession>
    <name>B0YDT7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_096740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096740"/>
    <dbReference type="HOGENOM" id="CLU_1447337_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="187" mass="20449" checksum="E7245C12ED695A46" modified="2008-04-08" version="1">MVVFRYDVVVVVVVLLLRFPLLLSLGVRRPWDGGRAGGLEGNANADIQRAFIYSHRRHIGPSDSSGISGPKTHDSARGHHPSQTPKLPDRISNDINNVLNTDVEVNVAVCPLGLNPKGTRAKLHRLVLTADRLLNLPFAISIRIFFTTCMQSDTLEDASLVWSTTSQVSAAVGRLVRDAWVIDHVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE35</accession>
    <name>B0YE35_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_097700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097700"/>
    <dbReference type="HOGENOM" id="CLU_079676_0_0_1"/>
    <dbReference type="OrthoDB" id="3483554at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="43"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="289" mass="34031" checksum="DCE5321A91C70844" modified="2008-04-08" version="1">MAHEAPLTRAMVSKFLRSYLQGITEEDKHPWDLNYSVDRHKPLLRTWDKWSGSQPSQRNIMLSRLPRQRLDSSELRKKFLATHADYKDWTPTPFISFTQLKQDLEENAVFRAAKRDSQRITVVNPNVRIENGFPILNMDIEMRHYGIRDPYNRSNEYYRDHYICLWEVTEPEVVGHWQWDDLKGNNRWYEEIIMPAFEKHNERSFALSARRETLDMSALLGALPDNSWPLIGKESPGRLSALFSEGNASSDEDEVNREEEYNSYDSYDSYDEGEANAIDNLFKILEGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE65</accession>
    <name>B0YE65_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_098000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098000"/>
    <dbReference type="HOGENOM" id="CLU_518706_0_0_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="B0YE65"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002875">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP47949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="525" mass="59878" checksum="83F3C714F3AB65BD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0YED5</accession>
    <name>B0YED5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_098800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YED5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098800"/>
    <dbReference type="HOGENOM" id="CLU_064119_0_0_1"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="PhylomeDB" id="B0YED5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="108"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="374" mass="42489" checksum="3B4D9B73C2E2152F" modified="2008-04-08" version="1">MAIHPTLPSQANSQGRLTPQQTRAISAWSEQAAASLRNLTLSESVSASDRNVEFISTRDSPLRGSSVPLSIPLDDPAPVVHTGAVPRVKLVTRESETQPVASVSFRRREPIRRDSLKRREALLKGKDGSRRRQRWENDRLLHNPWVEPPAPSDWAVQPTYPRHDPMPYYLAPLWDMKYAHLDRTSSQQTQKGTRHEKHRVPKELRMRLKHARAARGMLQDLEEDIRQFIQTWSEKQLMLRKEGLEDAPLSSEDESEDEVVFVGRNGQMHDSPEHKTRLRELRANLSQHNERDGEKMVFESPVDDRAAGFGYYGLHTWSITVGEPARREAYVGFHMPAPGSRPGLTTHVSVPSNAQQGAMMKPGDDLPKPLWAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEG9</accession>
    <name>B0YEG9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_099140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEG9"/>
    <dbReference type="HOGENOM" id="CLU_055156_0_0_1"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="PhylomeDB" id="B0YEG9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="62"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="297" mass="34253" checksum="15CA26AD4708FB05" modified="2008-04-08" version="1">MAWGIEVESVVSLLLEKHCCELSCPPTVLRTDCQESVRTATTYLPERNAWASTVPTQDQVLVPETLLKKRKSQEQARAAAREEAQKRKEANKKKREAIFKRAEAYVKEYRDAEREKIRLARVARQQGNFYVPDEPKLAFVIRIKGINKIAPQPRKILQLLRLVQINNGTFVRLTKATQEMLTIINPYIAYGYPNLKSVRELIYKRGYGKVNKQRVPLTDNQVIEEALGKYGIVCMEDLIHEIYTVGPNFKQANNFLWPFKLSNPTGGFRTRKFKHYIEGGDTGNREENINALIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEH7</accession>
    <name>B0YEH7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 alkane hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_099220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099220"/>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0YEH7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="515" mass="58423" checksum="5CF797A6F4B33E43" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEI4</accession>
    <name>B0YEI4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_099290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099290"/>
    <dbReference type="HOGENOM" id="CLU_032662_2_1_1"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="PhylomeDB" id="B0YEI4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="492" mass="54500" checksum="84AD271031087EFB" modified="2008-04-08" version="1">MALLSINAGGASGGFLYNSSLAKTRVCITAETPDFDTAFIRQWQDEGFEVMYLPYNDGGKEYTSQLKSIKEGLGVGVNYAVIALGDAASFCLDFYLKPTNASRLSALICYYPTNIPDPRSSFPPSVRFLTHLAGETIDVTTVPTALGLQGKKRRTTRRINQGIGTGERLNIGHQAYTYDNVQPGFAEHDLEEYDRLAAELAFSRSLQVIRSTVTDKIDLEKRWEDHLEARFFSMNLNNVMEQYVDHLTPNVTYAPTISGGIGARDLRRFYEHHFLRNLPPSMRLRLLSRTIGVDRVVDELYASFEHTQEIPWMLPGVPPTNKKVEAILISIVSLRSGKLYSEHVYWDQASVLVQIGLLDPKLVPQGVEGVDRLPVVGKEAARRILTEDPESEQRRYHNRLIRATHAKHKGQHGKHELVEGSGAELRSEAGDSVKPGNVKGKSVQGQSWPEKEDGADGEEEETGTGRNGNGVANGSNGKRAASVEDDNGENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEJ2</accession>
    <name>B0YEJ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome associated DnaJ chaperone Zuotin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_099370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099370"/>
    <dbReference type="HOGENOM" id="CLU_019916_1_0_1"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="PhylomeDB" id="B0YEJ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="446" mass="51255" checksum="89C025C7103CE5BE" modified="2008-04-08" version="1">MASQVINVTLPALPQGWSAEKDFTAVGTLSATTQRNLEPVGPHFLAHARRKRHHRTFSEDERIQAQQNVKKTEDDDDDEISEPEDPVMLSRDAKDWKAQDHYAVLGLSKYRWRATPEQIKRAHRKKVLRHHPDKKAALGDRDENDNFFKCIQKAHELLTDPVKRRQFDSVDEAADVDPPSKKEVAKRGFYKAWGPVFEAEARFSKVQPVPQLGDENSTQEEVETFYNFWYNFDSWRSFEYLDEDVPDDNENRDQKRHIEKKNANARRKRKTEDIARLRHLVDDCLAQDERIKKFRQQARAGKDKKRLEKEAEAKRLAEEKEKARLEEEQRKKEAEEAAKAEREKNKKAKEAAKNAAKKNKRILKGSVKDVNYFAESGEPSPAQVDSVLTDVDSIIAKIDSEELAALAERLTTAGKDAAAVKGVWTEEVKRLVDAGKLKDGEAKFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEN5</accession>
    <name>B0YEN5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_099800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099800"/>
    <dbReference type="HOGENOM" id="CLU_023254_3_0_1"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51951" checksum="42A35505D7C4C176" modified="2008-04-08" version="1">MPFEFIDNHNDLSHNDAARKRIRSHAALGKNRGKKIMRPSTKGVSTTTITSFRIPFIMRGDSKAKRQDPTIERPIDDGLIFPGLLPGESKGIVKEVISFLSSMGFSPELSNGLDYGELSAPVCVQNMFVDEASMRHASNTFCLLQQKISLQSVITDLTIAAVIGMAQYEHQLHQFQQGSVHVHGLWRMAQLRGGILKLMEGQSGLGEKILRYVRSGTIRRYVFCTYIHVSRVDLEYALQLGTPTLFRLEEAEWAFMGMRQFSDVHAQPNGKDYFPRSQQHILGSLPINLRDLFLDVLFLASSLNNAMTGDSPKLGVFQLHQNIILLGYRLVKLKPLGLPLRSSSLENRVHLGLAAFLASFLQGWDGQISPNHLLSRSLLASVHQHLSAEQNEQELSLWALFIGAVLPSSWNDSTWVLKTRVTLKALGIDSWGDIRDILGKYPWVNAIHDPPGQTLWYRCLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YES1</accession>
    <name>B0YES1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-sugar hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_100170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YES1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100170"/>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_1"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="PhylomeDB" id="B0YES1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF41">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="174"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="396" mass="43509" checksum="7A9E62C908026385" modified="2008-04-08" version="1">MVAQELARHLRLNEGCDFVIAISHSRLAEDIRIANNAAHGIAKVDLILGGHDHEVLHRFHGDTEEDSEIIQQGTRNEDIVSNGVVDQVAGDIRIVKSGTNWRGLSILRLMARRLPDGRATIETVKLKQYVDIAQSSECSSLSVCPRIRKMAAEIQQRVGSVVQEPLVHTTTPLDGRCSVIRSSETNLGNMLADAYRAYYGADIALVNSGSIRCDRIIDPSSSPLHVKDIIEICPFENPVVVKRVSGRALHEALENSVSDLHVDGRFMQCSGLHVVADWQQQEGHRILQLSLVQSSFAPPKRIIPSQLYSVVMSSFIAAGFDGYTCFQSLETLVDKETAVTDTGLLLRIFGYDKEGLNDGNTTGIDRARRAIICGRHGLDSLPIVSPTVEAKIQFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJP5</accession>
    <name>H9CJP5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">NADH-ubiquinone oxidoreductase chain 3</fullName>
            <ecNumber evidence="4 17">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_m0470</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="18"/>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4 17"/>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353064.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJP5"/>
    <dbReference type="GeneID" id="11948040"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1610:FF:000009">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058:SF9">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 17 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <keyword evidence="13 17" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFE02845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="135" mass="15528" checksum="95A424111F88E8B6" modified="2012-05-16" version="1">MTTTTFFLFLIPVLAIILLAVNLILSPHNPYQEKDSAFECGFHSFLGQNRTQFSISFFIFALLFLLFDLEILLVYPYVVSAYTNGIYGLVIMLVFFLVLTLGFAFELGKNALKIESRQVFNFNYKSWNGYSLIYS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMC1</accession>
    <name>ER10A_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase erg10A, mitochondrial</fullName>
            <ecNumber evidence="6">2.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Acetoacetyl-CoA thiolase erg10A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ergosterol biosynthesis protein 10A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">erg10A</name>
        <name type="ORF">AFUB_000550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2020" name="Appl. Environ. Microbiol." volume="86" first="0" last="0">
            <title>Characterization of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase as an antifungal target.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Wei W."/>
                <person name="Fan J."/>
                <person name="Jin C."/>
                <person name="Lu L."/>
                <person name="Fang W."/>
            </authorList>
            <dbReference type="PubMed" id="32005728"/>
            <dbReference type="DOI" id="10.1128/AEM.02986-19"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 36-432</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>BIOTECHNOLOGY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial acetyl-CoA acetyltransferase that catalyzes both the formation and degradation of acetoacetyl-CoA (PubMed:32005728). Has no overlapping function with erg10B and seems not to be involved in ergosterol biosynthesis (PubMed:32005728). Plays an important role in growth, morphogenesis and maintaining mitochondrial function including the response to oxidative stresses (PubMed:32005728).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>2 acetyl-CoA = acetoacetyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21036"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:21037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="6">26 uM for CoA</KM>
            <KM evidence="6">43 uM for acetoacetyl-CoA</KM>
            <KM evidence="6">232 uM for acetyl-CoA</KM>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Leads to lethality.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="9">Mitochondrial erg10A is essential for A.fumigatus cell viability and might be a potential drug target to feed the antifungal drug development pipeline.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Even though it is not involved in catalysis directly, the Cl(-) anion stabilizes the catalytic site via both direct and water-mediated hydrogen bonds to catalytic residues and residues adjacent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="6"/>
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        <property type="protein sequence ID" value="EDP55365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="A/B/C/D=32-433"/>
    </dbReference>
    <dbReference type="PDB" id="6L2G">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.41 A"/>
        <property type="chains" value="A/B/C/D=36-432"/>
    </dbReference>
    <dbReference type="PDBsum" id="6L2C"/>
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    <dbReference type="AlphaFoldDB" id="B0XMC1"/>
    <dbReference type="SMR" id="B0XMC1"/>
    <dbReference type="EnsemblFungi" id="EDP55365">
        <property type="protein sequence ID" value="EDP55365"/>
        <property type="gene ID" value="AFUB_000550"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000550"/>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_1"/>
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    <dbReference type="BRENDA" id="2.3.1.9">
        <property type="organism ID" value="508"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000454145" description="Acetyl-CoA acetyltransferase erg10A, mitochondrial" evidence="4">
        <location>
            <begin position="35"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </ligand>
    </feature>
    <feature type="strand" evidence="14">
        <location>
            <begin position="41"/>
            <end position="47"/>
        </location>
    </feature>
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            <begin position="56"/>
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            <begin position="62"/>
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        </location>
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    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P24752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P41338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q4WCL5"/>
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    </evidence>
    <evidence type="ECO:0000255" key="4"/>
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        <source>
            <dbReference type="PubMed" id="32005728"/>
        </source>
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            <dbReference type="PubMed" id="32005728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="32005728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="12">
        <source>
            <dbReference type="PDB" id="6L2C"/>
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    </evidence>
    <evidence type="ECO:0007744" key="13">
        <source>
            <dbReference type="PDB" id="6L2G"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6L2G"/>
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    </evidence>
    <sequence length="433" mass="45710" checksum="4D5B4C442DAAABA0" modified="2008-04-08" version="1" precursor="true">MAIQTTTGLAARLVAKRATFPASRRNFSASRSALKEIQEAYILSGARTPTAKFNGSFVSVSAPELGAVAIKSAVSKSGVPVEKITDVYMGNVLQGAVGQAPARQASMFAGLSPTVESMTVNKVCASGLKAVALAAQNIQLGLAEAQVAGGMENMSRVPYYLPRSTQLPPFGEIKLQDGLIQDGLWDVYNQFHMGICAEKTAKKYEISREEQDQYAIQSYQRAQAAWKENKFAEEIAPVTVKGKKGETVVERDEGYENLRIDKMATLKPAFLRDGTGTVTAGNASTMNDGASALVLGSKAIAREFAQGNRALARIVSTADAAIDPVDFPVAPAKAVPIALERAGITKDQVAVWEFNEAFAAVIKANEKILGLQNARVNPLGGAISLGHALGSSGSRILVTLLHQLQPGEYGVAAICNGGGAATAMVVQKLDRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMG0</accession>
    <name>B0XMG0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_000120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
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            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000120"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B0XMG0"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="61"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="529" mass="56964" checksum="FA8607BF15A4391D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMV2</accession>
    <name>B0XMV2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_003410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003410"/>
    <dbReference type="HOGENOM" id="CLU_150144_2_1_1"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="PhylomeDB" id="B0XMV2"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="79" mass="8665" checksum="F78F920576DD8393" modified="2008-04-08" version="1">MLLVATAIFLYYTAWTLLMPFVDTGHPLHDLFPPRVWAIRIPVILTLLGSAVVGTFIGLVMINSNRKKAAKAAAAKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNH0</accession>
    <name>B0XNH0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylserotonin methytransferase-like protein (ASMTL), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_015120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015120"/>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="PhylomeDB" id="B0XNH0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="272" mass="29740" checksum="3958414701481E4C" modified="2008-04-08" version="1">MADSKDKLLSQVDDITPDPPPAYDASAAPTPRLPRPPPLSLPVLNHLRTKRVILASASPRRRQILSLLGLPFEVIPSDAVEDFPKTMEPFEYVLATATKKAQAVYSAEINNEEKGEPALILAADTVVVDNLSGSILEKPRSEAQHIAMLKMLRDNRMHKVYTAMVAMAPLESARQPGYALETHIEETDVVFDRDVTDDLIVAYVRTREGADKAGGYGLQGLGSILVESIQGSWDNVVGLPLKAALKLIEKVMAKADDDNGDEMLEGDEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNI9</accession>
    <name>B0XNI9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_015310</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015310"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="PhylomeDB" id="B0XNI9"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP56811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="366" mass="39049" checksum="22297537E5AFFE61" modified="2008-04-08" version="1">MPSYNIVVFAGDHCGPEVTAEAIKVLRVIEKCRDDATFNLQDQLLGGASIDATGSPLTDEALNAAKNADAVLLGAIGGPKWGTGAVRPEQGLLRLRKEMGTFGNLRPCNFAAPSLVDGSPLRPEVCRGVDFNIIRELTGGIYFGDRKEDDGSGFAMDTEPYSRAEIERITRLAAHLALQHNPPLPVWSLDKANVLATSRLWRKTVTEVMAKEFPQLKVEHQLIDSAAMIMVKEPRKLNGIVVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKTKVNGIYEPIHGSAPDIAGKGIVNPVAAILSVAMMMQYSLNRMDDARAIETAVRNVIEAGIRTADIGGKSTTSEVGDAVAAELEKLLKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-03-23" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP71</accession>
    <name>XYND_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable exo-1,4-beta-xylosidase xlnD</fullName>
            <ecNumber>3.2.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>1,4-beta-D-xylan xylohydrolase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Beta-xylosidase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Beta-xylosidase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Xylobiase xlnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">xlnD</name>
        <name type="synonym">xylA</name>
        <name type="ORF">AFUB_016310</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP71"/>
    <dbReference type="SMR" id="B0XP71"/>
    <dbReference type="GlyCosmos" id="B0XP71">
        <property type="glycosylation" value="13 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP56909">
        <property type="protein sequence ID" value="EDP56909"/>
        <property type="gene ID" value="AFUB_016310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016310"/>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="PhylomeDB" id="B0XP71"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001420">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000009">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF13">
        <property type="entry name" value="EXO-1,4-BETA-XYLOSIDASE XLND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393286" description="Probable exo-1,4-beta-xylosidase xlnD">
        <location>
            <begin position="21"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="792" mass="86399" checksum="B178269570DE7682" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPC4</accession>
    <name>B0XPC4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_016840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016840"/>
    <dbReference type="HOGENOM" id="CLU_030884_1_0_1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="PhylomeDB" id="B0XPC4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP56962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50456" checksum="F21EDA4346250D32" modified="2008-04-08" version="1">MGLNEFHQDDAAVESGGVSQQRSLPYRIYTHSWFQILLISFICFCCPGMYNALSGLGGSGQVDPTVAANATVALLAATAATALFIVGPIFDRVGPRVCLLIGGWTYSLYSGSLLCFNHTANGAFVIAAGAILGVGASFLWVAQGAIMTTYVPESQKGRAIAAFWIIFNLGGGVGSLASFGLNYHSHSGTVTDGTYIALLIIMAIGWLLGSLICPPASVRVQGLQPTAETEKNWRRTAQLTAQTMTDWRVLCMIPMFFCANVFYSYQQNIVNGMTFNIRTRSLNGSLYWIAQMLGGLVIGLILDMPRVNRQNRARVGWLFLFATGMAIWGGGYAFQKWYDRRMAQGHKQDIDYTQSGLSTGPIFLYIFYGAYDAFWQGFCYWLMGARSNSPAVAAILVGAYKTFQATGGAMAWRLNALAKPAMTQFAMDWGLCMGALVVAIPSVLAVTLTSEVHEEVRQTKDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPG1</accession>
    <name>B0XPG1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin ligase complex F-box protein GRR1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_006360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006360"/>
    <dbReference type="HOGENOM" id="CLU_010840_2_0_1"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="PhylomeDB" id="B0XPG1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000251">
        <property type="entry name" value="Ubiquitin ligase complex F-box protein GRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000381">
        <property type="entry name" value="Ubiquitin ligase complex F-box protein GRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001074">
        <property type="entry name" value="Ubiquitin ligase complex F-box protein GRR1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="6">
        <location>
            <begin position="213"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="586" mass="65015" checksum="3373EEF6A24CD344" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPM1</accession>
    <name>B0XPM1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_006870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006870"/>
    <dbReference type="HOGENOM" id="CLU_008244_2_0_1"/>
    <dbReference type="OrthoDB" id="5284003at2759"/>
    <dbReference type="PhylomeDB" id="B0XPM1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54724" checksum="0480303EDD08B1F1" modified="2008-04-08" version="1">MIGTLVASFPRRPKLHLKTEAEKAAFPHSLALVKRCHDVAVQARGVGYLDRSATVHDAAISYFLGLCSAYVYNMRRCRMYLAECRTMLHVYDLCRQSTMQSSYGPTSPISSSSATSQDRLSGPTERPVDMIEQELARRLFYVTLVGYRSIQQLGSADTPIYLAPETPTERYPPLPLEVDDEFIFSTHVEPQPTNRVSQLVGFNANVRVYNSYNALSAWEVAFGSGRIVDWQRQRSLLFECLQNSKTALANVPPELSLHPHRDDSADAAEDPWMRERRHIQYEIQKANIYVSQLATRSYLAEKYWSLYATWKMYFRRSEEGGPGTPVKVEGNTHKGIDDAAQSDYIGMAMAEERRLVVRDLFVLLQSVNELNMEPNGASFTGKVRQVASTLLNLPTSRTETTTFTPATPGPNPITLAEAESYLHAFIDTLIRLEGLAAPTLGTAGSSPHANGRRMSYLSDHKQEEEELRQWASLKDYQAKFSLFTEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-03-23" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPZ4</accession>
    <name>DRE2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe-S cluster assembly protein dre2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Anamorsin homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dre2</name>
        <name type="ORF">AFUB_008090</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with tah18. Interacts with mia40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin Cx2C motifs are involved in the recognition by the mitochondrial mia40-erv1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anamorsin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPZ4"/>
    <dbReference type="EnsemblFungi" id="EDP56108">
        <property type="protein sequence ID" value="EDP56108"/>
        <property type="gene ID" value="AFUB_008090"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067152_1_0_1"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="PhylomeDB" id="B0XPZ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000392379" description="Fe-S cluster assembly protein dre2">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal SAM-like domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="131"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="1">
        <location>
            <begin position="263"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="1">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <sequence length="300" mass="32403" checksum="EF38D578D2EED429" modified="2008-04-08" version="1">MAKQTLLLSPPSLSSQPGKLNETLQSYNRNATDLQMLDRLALGLASLPDSAYSSIVILAGGDNSFSESLKLINRQIFNQIIGSLRRGGYIYGQDAVSGIAFDHNEAILAGLIHVGNGKYQKPDIKEMQAVPLRLGRKNDHLAGAPSLQESAAEHPCPPETMISASTMNSNEASDDELINEDNLLDDSELSAPIIQRGPAPECRPKAGKRRRACKDCTCGLAQKLQEEDAVKRADADEQLDAMRLLHDDLAEVDFTVQGKVGSCGNCSLGDAFRCEGCPFIGLPAFQPGEEVRLLNNDVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ20</accession>
    <name>B0XQ20_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0160 domain protein MYG1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_008400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ20"/>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ20"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="364" mass="40027" checksum="6756EC7A0C6CEED8" modified="2008-04-08" version="1">MADETVAKKLKTSPPLIGTHNGHFHADEALAVYLLRQLPTYASSPLIRTRDPAQLATCHTVVDVGGEYDPASNRYDHHQRTFSTTFPNHNTRLSSAGLVYMHFGRAIIAQHTSLPLDHEDVTLLYEKLYTDFIEAVDANDNGVSVYDPAALASANIEKRFRDGGITIASVVNDMNNPDPTCPPGEPQDEDSLFNRASTFMGHVFTRKLHHAFTSWLPARATVGAAYQSRREVHPSGRIIILPQGGVPWKEHLYNFEKEASGAGDINPDEQVYYVLYPESATEGSKWRVQCVSVNEGSFESRKPLPESWRGVRDADLDGCLAAEAEKSGKPKIPEGAVFVHASGFIGGHKTKEGAFAMAVRSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ92</accession>
    <name>B0XQ92_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_009150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ92"/>
    <dbReference type="HOGENOM" id="CLU_078327_0_0_1"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ92"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="219" mass="23678" checksum="70A18DE86B9A4E31" modified="2008-04-08" version="1">MTQPNPYILAAENPSALLTLLRSNPAIASCQDEHGYSLLHAAASYGHADLLRALVGEFNVDVNLLDEDGETCLFVTENADIAKCLVEELGVDYNKRNDEGLTAQETIESDGAFPDVAAYLAKVMGISPSAPAGSSLDALNAPPPLPPNIRVNLGTVSEEEASAGTDQVDPEFKRRIDELAAREDFHSEATQNQLRQLVMDALSGSNIETQDRDVRRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQB6</accession>
    <name>B0XQB6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II beta 2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_009380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009380"/>
    <dbReference type="HOGENOM" id="CLU_035164_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="B0XQB6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038816">
        <property type="entry name" value="Stationary_phase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342:SF1">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="49773" checksum="24F67372D6DA397A" modified="2008-04-08" version="1">MPPSSGHLLLPKFWRAARFAYEKALKTFKAKFPEPTQQVSLRLQPAYARIPTRQPISRAAAIRQSRSNRYFSTRTANSFVSSLKNGLRGEHTAYRPSRVAANISRLTSRAPFASTLRPNLTGGTLGRTAGGYAIGAGRIGGARYFSHGPASPAQVINNVSMGVRAFFLSGQKARFDGIDPITGQKRYKAVSALQDQAERKMAAIPRTASGSFIDFQISPTITAFGLQKKAASAGAHYVETLNSDTLCFLSADFARALKDLAAVLNDLERLSSLGDLPISLHDRSTIRVRFPGCDAETVERLCDEVGVRRGRIGQDEDFNLRTGADLALLFPFAPSVSAPSDVAEFFFRQETSEGQSPDQVDWQAMMTSEDGTGHSPENPRKSSNELSFEDSPLFADKNPWASSSSGYSSINVSELGDRAFFPEVSSAGFYESASEDEGVEGIHRFLAECDRAEHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQQ9</accession>
    <name>B0XQQ9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_010830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010830"/>
    <dbReference type="HOGENOM" id="CLU_020336_47_0_1"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="PhylomeDB" id="B0XQQ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757777" evidence="1">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="68"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="31785" checksum="DAA424116BF4CCA3" modified="2008-04-08" version="1">MIGIPLLASLLLSGIAQGLAIAERATTPVWLTLPPTPPLPAPISEARISVDGVELWIQKYNEDAHKTPLVLDHGGLGYSAYFGAVLSRLIAKGHYVIALDRRGHGRSTFKEDDVFTFDLFADNIYEQLKAVGVSKYNVVGWSDGGATTIAALLNRKISPTIEKAFLFGAFMVPSDSNPNFPNTDINSEFVSRCAKEYSQLQPQANFTSFATKVATLEATLPQFTTDQLRTIDGSRVRIAGAQYDEAVNLDVPAKLHAAIPGSSLVILNNVSHFAPLQDPDQFTRALEDFFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQS5</accession>
    <name>B0XQS5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_010990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_010990"/>
    <dbReference type="HOGENOM" id="CLU_012712_1_1_1"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="PhylomeDB" id="B0XQS5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="426" mass="48673" checksum="3906EE0EC415D26E" modified="2008-04-08" version="1">MGSAGEMKDETLLPLRFIPLSYNHADSQASALRLVLTLNPQWEGPDNKIEFVRFTDGITNTLLKIINRKPGWTEEQIDNEAVLMRAYGNHTEILIDRERETTSHALLASRGLAPSLLARFQNGLLYRFIRGRPATHLDLVKPPLWRGVAQRLGQWHAVLPINGHSASSSSAKELPLSHHVDVDDQHQHEQEDDLDPIKPRVPGPNMWTVLQKWILALPTATEEQRTRRRALQKELERVVRELDDGRGLGDDGLVFAHCDLLCANVIILPSQCPATAATSDKEALKVQFIDYEYATPSPAAFDIANHFAEWGGYNCDYSMMPTRSVRRQFLTEYVKSYSQYRGIPECAQQEIVDRLYEDVDRFRGIPGLYWGVWALIQAQISQIDFDYASYAETRLGEYYAWRREVDGSRVQASEEMPLRERRWAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQZ7</accession>
    <name>B0XQZ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial hypoxia responsive domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_011720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011720"/>
    <dbReference type="HOGENOM" id="CLU_079101_0_0_1"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="PhylomeDB" id="B0XQZ7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP56461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="268" mass="29522" checksum="594CB52F54944A89" modified="2008-04-08" version="1">MKILSKEEEDAHYREVLKGGTVGGIVGLIGGFAGVVAASKRYATIRNLTLPMKSFLVTSSGTFFGIIAADHASRSFEASRNAERQWYESREERLRQEELAGMSFIDRTMAFARREKYKIVGATWVASMIGSFAMVSRNPYLTGSQKIVQARVYAQGLTLAVLVASAAFEISDQRKGKGLLDAAKKGKKAAGEKEAAPTQTPTPAAAHDPQSGDLWKDMVAAEEERLKQKHQPLYEKPHEHQDDASAQAAPAPTEKHEEKEEKEEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR13</accession>
    <name>B0XR13_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_011880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011880"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_2_1"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="PhylomeDB" id="B0XR13"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000201">
        <property type="entry name" value="Salicylate hydroxylase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="168"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="468" mass="51890" checksum="597D23AC1B850512" modified="2008-04-08" version="1">MRLPQADADSASNMRSTATGWRRLSVGVVGGGIGGLAASIALRRAGHEVTIYERHDFAGEVGASISCAANGTRWLHEWKVDIAKGDPVVLRKLINRDWKTGEPVSVYDLAGYEERWGYVYYMFHRQYMHAMLKDCAMQEEGEGTPVKLLVNHQDINLETGLITFANGKTAQHDLIVGADGIGSAVRGIIGLKPEKKPADSSCLHANVRTEDAVRLGLVDYSQHSALEYWGGQDNSWDKIVLSPCNGGSLLSYYCFFPREKGDFTNHTWGGTDRPVEELLAPYPELDKQVRAHLAIGQEIRPWRLWVHQPYPYLVRNMVCLLGDAGHPMMPHQSQGACMAIEDAAALGILFRPDYFDGNVAEALQAYQEIRLPRVTKVQAASAKAAVNINERIGFSSNTNIPKYKVASEKDKLTIEEMNGYDMYKDVEEVLAKRRGKPFMQQYIRGLPIGLKLSNGTVVGQQPSAEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSD3</accession>
    <name>B0XSD3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_026780</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSD3"/>
    <dbReference type="SMR" id="B0XSD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026780"/>
    <dbReference type="HOGENOM" id="CLU_013640_4_0_1"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="PhylomeDB" id="B0XSD3"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000313">
        <property type="entry name" value="Dihydroorotate reductase PyrE, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="145"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="478"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP54619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="531" mass="56752" checksum="8FD7DA9E77234512" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSR9</accession>
    <name>B0XSR9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_017370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017370"/>
    <dbReference type="HOGENOM" id="CLU_009646_3_2_1"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="PhylomeDB" id="B0XSR9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="187"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="580" mass="63195" checksum="5510378AF76E12B2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSX9</accession>
    <name>B0XSX9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_028170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028170"/>
    <dbReference type="HOGENOM" id="CLU_799184_0_0_1"/>
    <dbReference type="OrthoDB" id="4499526at2759"/>
    <dbReference type="PhylomeDB" id="B0XSX9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="347" mass="38450" checksum="80797142F5FECFCB" modified="2008-04-08" version="1">MDATGRPPTSHSSNSLLSRVVRVFRVYTRLLRDGKAEMGRALVQRSLFVVDGHLTEYGRNFGFSHRHTECAAYHLQASRNAMGDSSAVRCIGVKVDIWMQNGSLWAKDSMAAVSASEVLSSAYFKSMLEKLNAMNSHLDSFAHSAEASPLGLFDQEAEHSSILLLKLRSPVEAAWPDLAPLLEKLRTGRHVSYMNGTRLVVRPVTVVISSKNLSYQDRTNLTDSDVILLDTSLESLPRAHHTEGGEETGGDNKAATLGTEVSPARNSTTRTVMATADFRASVGLPRRGRFSKEQIELIRAHVRAAHHHGLLVQYTGIQCLPWQLRRVILRVLAQERVDLIENVQNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSY0</accession>
    <name>B0XSY0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone deacetylation protein Rxt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_028180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028180"/>
    <dbReference type="HOGENOM" id="CLU_005227_0_0_1"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1045" mass="113222" checksum="B2682CC865DA0CD2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT74</accession>
    <name>B0XT74_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cu-dependent DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_018270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT74"/>
    <dbReference type="HOGENOM" id="CLU_082176_0_0_1"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="258" mass="26817" checksum="D13FFC78C82B4137" modified="2008-04-08" version="1">MLIDGEKWACEACVRGHRVTTCKHNGTYSSILSLSFSKKGRPFSTCSVCNCTPCQAPEEHTKLRREAESNAFQPIAPRPSLDSATPTNPAASHAAISPPLGSRPSAAGAVPARPGLSPRPRSSTETDPQLGMSQSPGYTSGDSYAQRPPQAHPGARSTTPALPVPLPVFTTAAPTSHFPLTCGSFATPALASVADTPASMTLMHGDAHGAEFLFADGNGYAGDGVFSLDDLDVGVGVGEGAMMPPEWGDHFWLGDDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTE0</accession>
    <name>B0XTE0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Chitin synthase E</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Chitin-UDP acetyl-glucosaminyl transferase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Class-V chitin synthase E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">AFUB_029080</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. Important for hyphal growth and conidiophore development but not pathogenicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cell tip</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029080"/>
    <dbReference type="HOGENOM" id="CLU_000192_0_2_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="PhylomeDB" id="B0XTE0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000337">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 24" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 24" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 24" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="928"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1196"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1594"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1621"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1649"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="28">
        <location>
            <begin position="1"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="27">
        <location>
            <begin position="952"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="29">
        <location>
            <begin position="1790"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00071787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00075289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EDP54849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1848" mass="205307" checksum="7176CCB3B69E24DD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTU6</accession>
    <name>EGLX_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable endo-1,3(4)-beta-glucanase AFUB_029980</fullName>
            <ecNumber>3.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Mixed-linked glucanase AFUB_029980</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_029980</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTU6"/>
    <dbReference type="SMR" id="B0XTU6"/>
    <dbReference type="EnsemblFungi" id="EDP54938">
        <property type="protein sequence ID" value="EDP54938"/>
        <property type="gene ID" value="AFUB_029980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029980"/>
    <dbReference type="HOGENOM" id="CLU_016972_4_0_1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="PhylomeDB" id="B0XTU6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF58">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE XGEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395084" description="Probable endo-1,3(4)-beta-glucanase AFUB_029980">
        <location>
            <begin position="22"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000395085" description="Removed in mature form" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="36"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated asparagine" evidence="2">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="652" mass="65993" checksum="B2A3477AC381AB33" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUR3</accession>
    <name>B0XUR3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_020980</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020980"/>
    <dbReference type="HOGENOM" id="CLU_004585_4_2_1"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="PhylomeDB" id="B0XUR3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.160:FF:000001">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.486.10:FF:000011">
        <property type="entry name" value="ATP-depentend DNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="284"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="726"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="789"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="873"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="918"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110836" checksum="43AAAC48644B55C3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUT1</accession>
    <name>B0XUT1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_021160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUT1"/>
    <dbReference type="HOGENOM" id="CLU_090693_0_0_1"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30902" checksum="37FF912065D89815" modified="2008-04-08" version="1">MRNSFADVPPDVRFQISWTDIRVACMAFTKPIFPFVRYARPSGLTLIPPSKDHARTASRLIQLFEIPGVFGEPMSKAIYDLTELIWYAEWIKGDPKSSQSFDDETEDYFNTEVLYVEYALHTDRYTPTGETKGDATIEGCVRLACLLFHNSTIWEFYPAMGPVFSKPIVGLRVALETTIPAGYFNLCRELLIWVLFVGACSSRLLAREHTFFMTELTMAVRNQGFHSWQDLRELLLGYFYVDRCYLTSLRELWDEIHIDADASRLNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUX8</accession>
    <name>B0XUX8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Translocon-associated protein, alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_031800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031800"/>
    <dbReference type="HOGENOM" id="CLU_068820_0_0_1"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="PhylomeDB" id="B0XUX8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758365" evidence="11">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="261" mass="28158" checksum="926CE4054AB61E5C" modified="2008-04-08" version="1">MARFGLLSLALFSVQALIGGGLAADTTENTQDIPEVQKLAVSAEASFPASEIFGVKLVNGHPTQALITFTNEEAAPVTVNFVGGSLSTLDEKSQIVRNLTATRYGIEIPAGQKESVSYSFATEMHPQDLRLTIASIISDSEGKFFTVYAHNGTVSVVEPETSLFDPQIIFLYFFLLACFAGTVYFFYTIWIAPYFPQKRKAGKAADFSKKSSGASKKAEEGPGSPAASSATTYNAEWIPAHHINRPEARKVKGSSRSKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV98</accession>
    <name>B0XV98_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SNF7 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_032360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032360"/>
    <dbReference type="HOGENOM" id="CLU_021165_2_0_1"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="PhylomeDB" id="B0XV98"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53779" checksum="CD82384D700B01F1" modified="2008-04-08" version="1">MSDLLNYILTQEDSFKKNRLPSLYSDFTLQKKTNPDGYAVNVAAWERALTRAARRGYVSTSPSREPSSTTGTAVQSDHLILRTDDSLLRDLEIPEYGRPVALGAMLDEAIRKHSMVPLQVFKANALSLQQRQWRIINPGALSPWNVMTWGMKQLRGFVVGSDTPETSARLQVQELVLVENLKEAADRVVKQTLGGSRSKMDLIYSKEHFTEEFATVLNKDSGLSSADFDVLLLYLSRDIGAIAYDGKTIRFRPSNDSPREITDQDTTIASIKSLLSTMTKQIDRLENKIEELNLTAKVAIQKKNRVSALAAVRSKKLAEHNLKQRLDTVTQLEEVYSKIENAADQVEYVRVMEASTGVLRGLHTQIGGVERVEDVVEELREEMSRVDEIGNIMNEVAPEIDETELDDELEELESRERQAVEEKEAEKTRKRLAELDDLEQKAKEAAHTAASEQSVDSAIEESIEKLSHMSVEESSGAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVQ6</accession>
    <name>B0XVQ6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthetase PksP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_033290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6 malonyl-CoA + acetyl-CoA + 6 H(+) = naphtopyrone YWA1 + 6 CO2 + 7 CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:62652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:133763"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:62653"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="aspfu-PKSP">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033290"/>
    <dbReference type="HOGENOM" id="CLU_000022_6_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B0XVQ6"/>
    <dbReference type="PHI-base" id="PHI:7335"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046148">
        <property type="term" value="P:pigment biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000011">
        <property type="entry name" value="Polyketide synthetase PksP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000116">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF45">
        <property type="entry name" value="CONIDIAL PIGMENT POLYKETIDE SYNTHASE ALB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="375"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1294"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1647"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1768"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1294"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1453"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1611"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1724"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1627"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1738"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2146" mass="234495" checksum="03D724B868C9DA75" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVQ7</accession>
    <name>B0XVQ7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfatase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_033300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033300"/>
    <dbReference type="HOGENOM" id="CLU_016056_0_0_1"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF32">
        <property type="entry name" value="SULFATASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G17610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="472"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="888" mass="100815" checksum="A599B5BBC867C99E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVV3</accession>
    <name>B0XVV3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Double-strand-break repair protein rad21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_022880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022880"/>
    <dbReference type="HOGENOM" id="CLU_015775_0_1_1"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="PhylomeDB" id="B0XVV3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="532"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="606" mass="66763" checksum="C0E45642722197B8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVZ9</accession>
    <name>B0XVZ9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_033580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033580"/>
    <dbReference type="HOGENOM" id="CLU_008511_3_1_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="PhylomeDB" id="B0XVZ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="273"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="630" mass="69933" checksum="21A3B678DF05BB94" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW02</accession>
    <name>B0XW02_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 43 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_033610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033610"/>
    <dbReference type="HOGENOM" id="CLU_015362_0_0_1"/>
    <dbReference type="OrthoDB" id="2730619at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043750">
        <property type="entry name" value="DUF5695"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18951">
        <property type="entry name" value="DUF5695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757957" description="Glycoside hydrolase family 43 protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="99469" checksum="1C48C5244CFB9932" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW51</accession>
    <name>B0XW51_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TOR signalling pathway protein TipA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_023590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023590"/>
    <dbReference type="HOGENOM" id="CLU_039187_0_1_1"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="PhylomeDB" id="B0XW51"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="266" mass="30768" checksum="2D3143AEF0A666D9" modified="2008-04-08" version="1">MNAAAVSPGVQRPNVISVKGFRIITQKLPILKAEPIEEMTKRLGIAPPEMIFGDNHVTIESENKDWGITFNAFDALDRVDKTGTSMLRVAHSKEWQKSREKAHEGIKDVVKPFDWSYTTDYTGTVHPNSRPFETTTKPIPIELLKRPDPILFFDEVILYEDELADNGIAMLSCKIRVMPDRLLLLSRFFMRLDNVLFRLRDTRLYVDFESKEVIREYQSKECDYERVRQSLATTRDDIPAIMRDPNRLSDILPLIEKRLEKVTLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW81</accession>
    <name>B0XW81_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-like serine hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_023890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023890"/>
    <dbReference type="HOGENOM" id="CLU_000288_144_6_1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="PhylomeDB" id="B0XW81"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="625" mass="68853" checksum="E8A586DA4947AF8D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW92</accession>
    <name>B0XW92_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_024000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024000"/>
    <dbReference type="HOGENOM" id="CLU_2721745_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="72" mass="7889" checksum="C9E8470A1E0154E3" modified="2008-04-08" version="1">MFVLCLSGLARWFDSLSGTIDQGKPGRYLIPGIGEHASTAPLHPDQKTVRKSLIPFSPYPSVQPQSDQSCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWR1</accession>
    <name>B0XWR1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_047010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047010"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="PhylomeDB" id="B0XWR1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF78">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="508" mass="57331" checksum="92CA585AB546C6F4" modified="2008-04-08" version="1">MGEQITDKDLLGEKAEMSHEEVAQLAELTEEEKVIEKKLRRRLDCTIMPLVILVYLMNYIDRNNYPAARLQGLERDLNLSDADYQTGLSILFVGYILMQVPSNLILNYMGRPSLYLGFFTSAWGLVSLLTSQVKSFGGIVACRFILGLVEAPFFAGVLFYLSKWYTKKELALRMSIFYAGSLLSGAFGSLIAAGILKGLDGKNGLAAWQWLYIIEGAITIAVGIAVMLFLPDFPSTWKRLSEEERHVANRRLAIEAADADVDEAGKMSQIKGLKLAFSDIKTYVLAIAYMSITGASGFQNFFPTLTSTLKYDHFISLLLVAPPYVFVVFYSMAHSHLSDRFGNRFWFFFYPIPVTIIGFIIFMTTDSFGPKYFSFFLMNIIFAQNGTIYAWIGNAIPRPPAKRAAAYAFINSIGNSASIWTPYTYRKQDFPHYRPALGVCIGLQTLGGIMAIIMYFHLRSLNKRLERLDDTEVTLTDKEIRRLERTAEIEGIDLAAARRLQKGFRYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWZ9</accession>
    <name>B0XWZ9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sarcosine oxidasee (formaldehyde-forming)</fullName>
            <ecNumber evidence="3">1.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_047220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sarcosine + O2 + H2O = formaldehyde + glycine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:13313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="EC" id="1.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047220"/>
    <dbReference type="HOGENOM" id="CLU_007884_2_1_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="PhylomeDB" id="B0XWZ9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000189">
        <property type="entry name" value="Monomeric sarcosine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008425">
        <property type="entry name" value="PRK11259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF7">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="381" mass="42027" checksum="54F5F178065E0EB1" modified="2008-04-08" version="1">MDHFDVAVVGLGVLGSGAAYYAAKKGAKVIAFEQFELGHVRGASHDTSRIVRTSNFAPEYVALAKSAYKDWAELEKITGYQMLTTTGGVVFFAPDSPTSASDFTRSLDTHDVPYELLDAQEVKRRWPQFNIPQSVSTVYTADSAIVHAAKTVSTLQSLARSHGAILKDNTPVERLIPQASGGVIIETPKGQFHAGKVILATDAWINKLLAPLSVHIPVSVMQEQVTYFKPTDAGTFEPDRFPVWIWHGANCFYGFPCYGEPTMKAGRDYSNNLMTPEQRTFVHSPQLLEQLTSFMNGFIPDQDRQPLRTITCQYTITPDRRFIISPLKNYPDIIVGLGAAHAFKFAPAFGRVLAELAVDGRTDEDISLWGIPKGATRNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX56</accession>
    <name>B0XX56_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc-containing alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_047810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_047810"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="PhylomeDB" id="B0XX56"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="180"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="360" mass="37928" checksum="6B5EBE5534973C77" modified="2008-04-08" version="1">MLCSLIWSSATPRGACIVEFTLKAVIYTGNNKFSVEDRPIPVILEPTDAIVKVLHTTICGTDLHILQGHVATCTPGRILGHEGVGVIDSLGAAVTNFKAGQTMPSQCESGGWILGNKIDGTQAEYVRIPHASFSLHALPEGIDPEVAVTLSDTVPTSYECGILNGDIQPGATVAIIGTGPIGLMILQMAKNLFGPAMTVVVGRGQPRLEIANAMGADHTLSVLGGQDEVISAALAVTKERGFDVVIEAVGTVESFAIAQALVGAGGTLASLGVFGESCELRLEKLWHRNICLRTRLVDGVSTPDLLKMVEAGGIDPRFLVSHRFTFDEIHNAYEAFEASSKHGALKVVVTLPEPTMNGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXD0</accession>
    <name>B0XXD0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain protein SNIP1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_037630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037630"/>
    <dbReference type="HOGENOM" id="CLU_022457_0_0_1"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="234"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP52597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="328" mass="38113" checksum="DA9A623C2BC8B5E3" modified="2008-04-08" version="1">MAESRAGYSEKRRRRSASESSISTRDDDRRLHTRERHRNGDRSSRRDSSRRRSSRSPTGRDARQLDSRDRRDRRERREGSDDHRRRRRHGSEERGHRRHRDRDSYDDRRRPSRKYRSRSRSRSPAGRTRSPESRGFPRSKAPLPSQNDAYTSSEVARREESSAPPPEKEKPNFGNTGRLAAETNTVNVGGGTVVLKYHEPPEARKPPAKEPWRLYVFKGEDLLEVVELAERSCWLIGRERLVADFPLDHPSCSKQHAAIQFRYVEKRNEFGDRIGKVKPYIIDLESANGSNVNGDTIPAGRYVELRDKDVLKFGLSSREYVLMLPQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY30</accession>
    <name>B0XY30_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_039450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY30"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039450"/>
    <dbReference type="HOGENOM" id="CLU_002227_3_0_1"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="PhylomeDB" id="B0XY30"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="301"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1013" mass="110191" checksum="5022FA05352C697A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYD0</accession>
    <name>B0XYD0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_040480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040480"/>
    <dbReference type="HOGENOM" id="CLU_064525_1_1_1"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="PhylomeDB" id="B0XYD0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="242" mass="26107" checksum="6B3D556C97AE5B1D" modified="2008-04-08" version="1">MATQTSFMTAMSNRSLRTVRSELEFLADASVITRQQLSSILAHLPNEAPQQANTPVPPPQQQQPVVAQSQPPPASYAPPTSQFANTSLNEKAALQQQQYSTPSIPPPAYPQAAPVLSVATALYAYTPTDAGDLALQPHDRVQVLEHMNADWWRGRNERTNLEGIFPRSYVNVIEEKGVSSPPPTNYGNLPLDVSQSGSAAPDEKRPGSKFEEHGKKFGKKMGNAAIFGAGATIGSNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYI8</accession>
    <name>B0XYI8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polymerase (RNA) II (DNA directed) polypeptide D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_041070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041070"/>
    <dbReference type="HOGENOM" id="CLU_110332_0_0_1"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="PhylomeDB" id="B0XYI8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="29"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="148" mass="16832" checksum="E9921E969040F266" modified="2008-04-08" version="1">MSVQLPPATHRKRALPQGELEAASTLKLGADQNTHTLSLSEARLVINKVLENKRRGGKKYEEPENLTKTLDYLEVFARFKDEENIKAVERLLNSHTELEMFERSQLGSLCCDNAEEAKSLIPSLQHKISDADLQELLDELTKLRNFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYX4</accession>
    <name>B0XYX4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_042410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042410"/>
    <dbReference type="HOGENOM" id="CLU_2027333_0_0_1"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="PhylomeDB" id="B0XYX4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="112" mass="12128" checksum="95D85D670514408A" modified="2008-04-08" version="1">MQHLGYPLAVLLDICLDYELAARRVLVVAGPVLAVDLLNPTPQAEARKHKLKTLVPAPRSFFMDVKCPGCFTITTVFSHAQTVVVCAGCSTVLCQPTGGKARLTEGCSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZD5</accession>
    <name>B0XZD5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_044030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044030"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0XZD5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000115">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF228">
        <property type="entry name" value="P450 MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="497" mass="56146" checksum="E7C66837787C6856" modified="2008-04-08" version="1">MFLLTIVAVSSFLVLLLYKILISPYFLSPLSKIPNAHFTAPISDYWIERKRRSGEEVLTIYNLHREHGPVVRLGPNELSVNSLGGLHVIYTGAFEKHSFYRDTFVNFLTDNLVGMLPNDSHARQKRMLSKIYSKSYLHESVDLRNASSIILSQRLLPMLKNAAEKGEAINVLPLFQAVGMDFTSAFLFGTANSTTFLFDLPGWKRWLVEYERFKTLSGKERYLGFIERWCLSLCSRVQSNEHPNDVPVATNPVVYSQLRQSLEKHPDQRPLDLALASELLDHLVAGHETSGITFVYMMWELSKRPRLQAELRQELLTLSPSLRYPLVELGDGSLPLLPSPAAIDSLPLLDAVVRETLRVHSPAPAPLPRITPSSSEGIAIEGYDRIPGGVKVSSSSYTLHRISEVYPQPFEWLPERWLDPGPGKIHDMRRLFWPFGSGGRMCLGSNFALQEIKLVMAAVYSNYTTSIVDDEGIEQDYAFISLPKGRKLMLKFTPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZL4</accession>
    <name>B0XZL4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_044450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044450"/>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="PhylomeDB" id="B0XZL4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="116"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="664" mass="74568" checksum="53DAA11B861D5719" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZZ2</accession>
    <name>GUF1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation factor guf1, mitochondrial</fullName>
            <ecNumber>3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor 4 homolog</fullName>
            <shortName evidence="1">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">GTPase guf1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">guf1</name>
        <name type="ORF">AFUB_034880</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EDP52324" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52324.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZZ2"/>
    <dbReference type="SMR" id="B0XZZ2"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="PhylomeDB" id="B0XZZ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000402874" description="Translation factor guf1, mitochondrial">
        <location>
            <begin position="44"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="66"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="683" mass="76019" checksum="47F5346903F8AAAA" modified="2011-01-11" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y027</accession>
    <name>B0Y027_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_045400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y027"/>
    <dbReference type="HOGENOM" id="CLU_014247_0_0_1"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="PhylomeDB" id="B0Y027"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="680" mass="75295" checksum="4A271AF020DE1E22" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0B5</accession>
    <name>B0Y0B5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar segregation protein (Pep7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_035420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0B5"/>
    <dbReference type="HOGENOM" id="CLU_026440_1_0_1"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0B5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="203"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="340"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="672" mass="74755" checksum="E1FD8DDC8D752C5A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0C2</accession>
    <name>B0Y0C2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_035490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0C2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035490"/>
    <dbReference type="HOGENOM" id="CLU_001116_0_0_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000126">
        <property type="entry name" value="Transferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="397"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="993" mass="109980" checksum="96946A7641D41319" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0K1</accession>
    <name>B0Y0K1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_057600</name>
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    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0K1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057600"/>
    <dbReference type="HOGENOM" id="CLU_007427_2_0_1"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0K1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="216"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="555" mass="62421" checksum="A10F904CCDF12801" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0N8</accession>
    <name>B0Y0N8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_057980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0N8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057980"/>
    <dbReference type="HOGENOM" id="CLU_2512217_0_0_1"/>
    <dbReference type="OrthoDB" id="10273148at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="85" mass="10138" checksum="84C1BCF2F238C67A" modified="2008-04-08" version="1">MCKDQDYISRCIIQARFEGRGLSVPRHRFPNPQLYKALGFPRRGKPRIYNGVLILLFLYWPWWFGWTPGTELVVGLWRITSDRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0T1</accession>
    <name>B0Y0T1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_058430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058430"/>
    <dbReference type="HOGENOM" id="CLU_001832_2_1_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0T1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="262"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="576"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="757"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1210"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP51822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1230" mass="138606" checksum="B84847B959938E61" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0W4</accession>
    <name>B0Y0W4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_058760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    </dbReference>
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    </feature>
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            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
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            <begin position="317"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="40058" checksum="19EBFB7DA8D11064" modified="2008-04-08" version="1">MSSQNDPSRPDEGRQDGFSKYLKRMKTILKRGPTARSSISNMQEITERPEPSQVASPRPTPAPAQKPTAKPTTQPTVVTHWSAIQEEKARALFAKYGLTLESGEWRSSSDMTVQRVAKPIRMRVRRTCHRCETTFGPDKVCVNCQHIRCTKCPRHTSTKPKDQAQNALEAIRAAQGHEPPRHMSKESQLAIPSRTGGQDLVLKPIRQRVRRTCHRCNTMFPNKDVTECPTCRHVRCKKCPREPYASIVQQLDNNQLIKARSKPHKYPDGYPGDAEPPPEPPARTWKKPRQRVHYTCHICSTPYRSRETTCSNCGQEKGSETIRDPPKKNKPELDPENLRRVEERLANMSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1D8</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">AFUB_059930</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Actin depolymerizing proteins"/>
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    </dbReference>
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        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="873"/>
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        <location>
            <begin position="996"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP51968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1160" mass="125111" checksum="CE088F097FACF486" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1H0</accession>
    <name>B0Y1H0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
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        <name evidence="17" type="ORF">AFUB_060300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
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                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
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                <person name="Whitty B.R."/>
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                <person name="Jiang B."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
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    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
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    </dbReference>
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        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_pol_A"/>
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    </dbReference>
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        <property type="entry name" value="DNApol_Exo"/>
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    </dbReference>
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        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
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        <property type="entry name" value="DNA_POLYMERASE_A"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="699"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1070"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1114"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1076"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP52000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1135" mass="129075" checksum="F747FEE970ED26B6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1T7</accession>
    <name>B0Y1T7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-1,2-mannosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_060800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060800"/>
    <dbReference type="HOGENOM" id="CLU_013298_0_1_1"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1T7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP52046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="492" mass="55094" checksum="4B84D209CE959B9E" modified="2008-04-08" version="1">MGTFRFGRLRSLLLATGAIFLISTFYLYWTPAPASVVPSSAFEVPLTERQIALWKALKSILEKNAPNCPSPVARADAHAVHFNATSTDARPDLTLLKDDDRKAMEEAHANYIRDIRVSEKLRSPHTAGTRGLVSTAGGSYLPVFLSSLRMLRRTGSALPVELFMKDATEYEKKICDGVLPDLGAKCVVLSEIVGKTPIAHYQLKAFAILFSSFEEIIWMDADCFPLHKPEELFDSEPFKTNGLVTWPDFWASTASPAYFELSRQPIPPVSARQSSETGVFMVSKEAHLTTLLLAAYYNYYGPSHYFRLLSQGAPGEGDKETFLQAATALGEPFYAVSERVQALGHWKPDGEGLSGSAMAQADPVEDYALTSQDKRRVIDPSVAKAPRVFFIHAHYPKFNPAENVFGTKWDTTPTLKADGSEGRAWTAPEDVVSRFGYDVERNYWEEIKWVSCDPKTQFQTWKNKTEVCQKVESYWQKVFAEPHEDDPKFTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1V3</accession>
    <name>B0Y1V3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF614 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_060960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1V3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060960"/>
    <dbReference type="HOGENOM" id="CLU_050253_1_0_1"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="334" mass="36894" checksum="070808DEFD308846" modified="2008-04-08" version="1">MDRQLRLDTSFGAGTQRYSFIETPLEMNPSRQRIERQVPLQEPETKVDACPFQHQGTVTEDVQPSYNEKAQLQHESAASVYPGSPPIEQHPAHYAPYAEDAPQQAQFDTVAPAYSYSAGPDPRPVKTDPDASGQFSESRKIIVAPDENPLHSPRLPRFPPPIMTNAPHQSTLISYHQPGQIAHPNQVVKGGTWSHGLCECSSIGTCCLGLLCPCILYGRTQYRLSMKGKKENPTNMLGHETCNGSCTAMALLCGCQWLLATVQHTRTRKAYGISGNVGSDCVRATCCTCCTLIQDEKEFKTREEERERVAWATGQALVSPYATPLQMSYGQPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y276</accession>
    <name>B0Y276_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_061540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y276"/>
    <dbReference type="SMR" id="B0Y276"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061540"/>
    <dbReference type="HOGENOM" id="CLU_065853_1_0_1"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="PhylomeDB" id="B0Y276"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="261" mass="28949" checksum="2DD90383D9FD5C65" modified="2008-04-08" version="1">MYLRAVHAETHIPLLQQFIRDNPLGILTTAIKSPNYPLLQSSHIPFVLDIPDTPTDKANSDLTPGTLRGHIAKQNPQAKALMEALAQHQAQTQSTTLELPDEVLILFNGPHHHYVTPKFYKDTKPATGKVVPTWNYSAVQAYGKITVYCDSKAEETGAFLSRQVNDLSRHAETAIMGYTGGERPGPWEVSDAPENYIELLKKNIIGVKVRIERLQGKFKMSQEMGAGDREGVIEGFEKLGTEVGMGIAKTVKERGDMKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2C5</accession>
    <name>B0Y2C5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anaphase promoting complex subunit (Cdc23)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_050970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2C5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050970"/>
    <dbReference type="HOGENOM" id="CLU_018320_2_0_1"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2C5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="13"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="689" mass="77922" checksum="BF7A511F34692921" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2N0</accession>
    <name>B0Y2N0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo-keto reductase (AKR13), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_062400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2N0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062400"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2N0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="341" mass="37922" checksum="AE43DC75822EC60F" modified="2008-04-08" version="1">MVANRQLGKNGPVVPALGLGLMGMSFWVYGSIPSDEERFKVLDRAVELGETFWDTSDLYGDNEELLGKWFRRTGKRDQIFLATKFGFVQGGKPHEINSSAEYCKKACEASLKRLGVDSIDLYYLHSPNPQTPIEETMRAMVELQAEGKIKHIGVSSVTSATLRRACKIANVVAVQTEYCVFSRDIEGPTGTNLLATCRELGVALVASCPLGRGVITSTFSRGEPVGNSEDKRPKIIPKFLEENRERNVKVASQFAALAEKKGCTVSQLALAWLLKQGNDIFPIPGTRRVEFLEENWGVLRISLTDNEEAEIRTFAEENKMVGGQVPDQFVEYLYRDTVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3M2</accession>
    <name>B0Y3M2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_054710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP51463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_054710"/>
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    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07625">
        <property type="entry name" value="BAR_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="128"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="591" mass="65002" checksum="357510B1D298BB57" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3Q7</accession>
    <name>B0Y3Q7_ASPFC</name>
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        <submittedName>
            <fullName evidence="9">C6 transcription factor AlcR</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">AFUB_055060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3Q7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055060"/>
    <dbReference type="HOGENOM" id="CLU_006237_0_0_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3Q7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="866" mass="96454" checksum="886DDC6393EDDBA3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y451</accession>
    <name>B0Y451_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor RfeG, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_056530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y451"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056530"/>
    <dbReference type="HOGENOM" id="CLU_086453_0_0_1"/>
    <dbReference type="OrthoDB" id="4146887at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="272" mass="30246" checksum="5B818775A070FD69" modified="2008-04-08" version="1">MTGRHGYEGRPERQNEYFIPGDGISREVIQADICRYLGNDALVRPGNHNGRQGYFIRAYRNLTSEMIADLKADSARWEADVMRRADQGYPRGSYIHDYNVRQAPNVVPAPYAASSIHEVRQQGGPSPPQPPSQPYVDPYTQAPYGATQSPPYTAPSSYPSSHSPFAAGQNPYPPQVPYSAPGQPPVSADMHPSYTYTSNTGYPYENGRSNAPRYTGPGYETESDYSPVTSGMTYPATTAPDPRIGMDPRYTPEYDRNRPQATRESQAPRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4F2</accession>
    <name>B0Y4F2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3a subunit 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_068880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4F2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068880"/>
    <dbReference type="HOGENOM" id="CLU_050757_1_0_1"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4F2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="238" mass="27428" checksum="C16368AA6FDF3DAD" modified="2008-04-08" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALETIDLDKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGRKHQTNLARRAAREQREGKNQDPAMLPGAMGVQVKKQAIKIGRPGYKITKIRDPLTRQLGLLFQLQYQEITPGVKPRVRFMSAFEQKVEEPPDKNFQYLVVAAEPYQTCGFKLQAREIDRREGRYWTWFDEDSKEFWIQIMFKTEREERFSGVPGLAPMGPKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4Q5</accession>
    <name>TVP38_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Golgi apparatus membrane protein tvp38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tvp38</name>
        <name type="ORF">AFUB_069910</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Golgi apparatus membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4Q5"/>
    <dbReference type="EnsemblFungi" id="EDP50654">
        <property type="protein sequence ID" value="EDP50654"/>
        <property type="gene ID" value="AFUB_069910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069910"/>
    <dbReference type="HOGENOM" id="CLU_041954_0_0_1"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4Q5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000343061" description="Golgi apparatus membrane protein tvp38">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="181"/>
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            <begin position="1"/>
            <end position="10"/>
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    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="418" mass="46734" checksum="FF50761C7F3D511B" modified="2008-04-08" version="1">MPADYTSTARALSLPMSPAESLSPAEEDTRPLWSHLASSRRNTASPSVRESTGLRDQVVNQATKMLRRTKKTWRRLTFWQRIGAIGAALLAILLGLSFMIFTGQVFFWLGPVAEKWEQSWLAFFVLWLCVFFVSFPPLVGWSTFGTISGFIYGIWKGWILYATATVLGSTCSFIVSRTILSKFVNRMMERDKRFAALALTLKYDGLKLLCMIRLCPLPYSVCNGAVSTFPTVHPLMYGLATALITPKLLVPAFIGSRIRILSEKNEEMSAASKAVNICSIILTIGIGVFTGWYIYRRTLARAKELEAKERADIRRSLQADHAAHRPHGSFSEDPDVNTAATTLARDEEERIGFNDFDDDNVDLVIDDDSGSEISPNLTKKQFPGPYRDEFTDNDSDVFGDGDGPDSQMFRLHTHVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">PE repeat family protein</fullName>
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        <name evidence="2" type="ORF">AFUB_070550</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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                <person name="Nierman W.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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    <sequence length="1187" mass="125786" checksum="295EFEEC033739A7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y535</accession>
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        <submittedName>
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        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
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                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
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                <person name="Sundaram J.P."/>
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                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
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    </evidence>
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    <sequence length="415" mass="45618" checksum="D3E685FA4046E4DD" modified="2008-04-08" version="1">MTSSSRSARSPSASPRIFSEVPTPDSEADGLDTLTPVRDGEEYVLVTGGLGFIGSHTCLELLKAGYNVLIVDDLSNSYRHVFSRILLAAKLHCDRTDGHCPKATLYDVDYRDTSAMRKLLDAYQRDPSTRQSRIIGVIHFAAFKQVEESIHTPLKYYRNNINGLVDLLVLLDQYRITTFIFSSSANVYGTLAEHRPLLHEDACTHQPDPGQRFGAFRPAEIHNSQITNPYGRTKLFGEAILADLARANPAWTIVALRYFNPIGCDASGLLGEDPKVHPSNLVPALVEILTGRRTELLIYGSDWETPDGTPVRDFIHVTDVARGHTAALAAARDGRVRDGFRTFNLGTGRGHSVLELVQTLETVSGRTIPRRVVGRRAGDIGSCVASAERAAAELGWTTAKSLTNACEDLWGYLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5G5</accession>
    <name>B0Y5G5_ASPFC</name>
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        <submittedName>
            <fullName evidence="6">Flavin-binding monooxygenase, putative</fullName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063320"/>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5G5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="627" mass="71444" checksum="2ABE8AED3256EFC9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5L7</accession>
    <name>B0Y5L7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquinone biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_063830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063830"/>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5L7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="216"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="624" mass="71292" checksum="4C0B89CD70CDD846" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5P9</accession>
    <name>B0Y5P9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1742-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_064160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5P9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064160"/>
    <dbReference type="HOGENOM" id="CLU_088285_2_0_1"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5P9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19016" checksum="0C3CD95965BC9384" modified="2008-04-08" version="1">MSLPNVWHLRRVADTAAKACFVCYKPSASVLITPDNKAAAKAKQEALAREIEIVKKEYEEKQRRKKEKEKEKKADDEPKNSDKKSKKSDKESDSGAKSLEKERDEKIESLTKSASSSATDDSPRIFALHKNFYQMRVDRQCNIEMAKRNRQRLQDPSAFPSVPSGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5U0</accession>
    <name>B0Y5U0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_064570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5U0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064570"/>
    <dbReference type="HOGENOM" id="CLU_045155_0_0_1"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5U0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="372" mass="41727" checksum="A8001F8C03316BAF" modified="2008-04-08" version="1">MAASGALASAPSPDLALDLHTNDTGDAGIESHSSQPQKQAEAEFVEFDPAKHLSFTPPSGSTLWHSSDTQSVVLFLLSAEEVFTKYHCSSGLAKGQLRGYTAECAPFVYDAWKHPKTLAIVSRIAGVDLVPVMDYEIGHINISVQSEEDKAEFLAAVAQKNSQDAGKNVSDSTWEGKDPIVDWHTDGYHYVCVVIFSDCEDMIERETELRRGNDEKIKVRSPQMVRLGSNPPETLHRTSSPSCPGNGRAITMVTSFRPRSPAIPDYTVLTTIRPISDLGEMHHQFAEYRFEILEARLREVNKYMRDRKRANRRFNPGFLKRFIHEQIEFLEHMDREIVEDDKVIKGVTGDSHLISEDLKLKQSKKRELAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Y4</accession>
    <name>B0Y5Y4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_065010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Y4"/>
    <dbReference type="HOGENOM" id="CLU_022142_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52721" checksum="BD901EE364A269B0" modified="2008-04-08" version="1">MDLKMKCEVDGAPPCRRCRHTNAPCIFKPRSNVLIAFASVLHWKAAAVQSIPERSQSVQGALVYHPSSPDQDSSSILGRLERIESLLGIGKEGNRSSLLTIDPDLEEESDDVSSRGLWKAVERLKIITSPPQDQNIWSYAVVTRLWISPLPELASLAGGYFTAICSAISELVVPSARPGTSGWTGSHISSSSSAEHTVFQDILGLIMASLSCEAYIETTDKWIALAYRLLLDHCPSNLEDATYDWRRLFSGIQVIDIEHASMHMRYPLLPRQPPIPALQHLDSQHDSAFRGLSQMMHQGLNHFVGRKLPTIWSFVSARDSDAVPSVGTPFTDKDSQVIRLWAKKLDEWLVQYNGASPRGFDLGSANITPSERQELLMSARAVLRLRQDDSSIWSNWDLILNTLKRSDPSTLSIHGVLAERLQSGIQSMHTPPDNGPDFAFPAPNMDYSWTIFDQQIMNLANPPWLFDDSSQAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6U6</accession>
    <name>B0Y6U6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Disintegrin-like metalloprotease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_068180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6U6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068180"/>
    <dbReference type="HOGENOM" id="CLU_012383_1_0_1"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6U6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000093">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760744" evidence="9">
        <location>
            <begin position="27"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="279"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="10">
        <location>
            <begin position="516"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="747" mass="80309" checksum="2DF3D8F255F6DC27" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6W6</accession>
    <name>B0Y6W6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prenyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_068380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068380"/>
    <dbReference type="HOGENOM" id="CLU_038505_0_2_1"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6W6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="403" mass="44651" checksum="24D40FC77DF9994C" modified="2008-04-08" version="1">MATSMHLSKLRNWFLASPPAEFIIAKLRELLIGALKQGPVPQHIAFVMDGNRRFARSHGIETVEGHNLGFEALARILEVCYKCGVKVVTIYAFSIENFKRSKFEVDALMDMAKVKLQQMAQHGDLLDRYGAKVRVLGRLDLLKPDVLDAVNRAVEMTSRNGERVLNICFPYTSRDEITGAIRDTVADYSKPLQSIRSNSSARTPFSEAQIALKIRAQAQSAKVEQDTISDNESTSVSSIPEEDSSDRSEGPDRVYEAGSGFSSSTTLHLGGHQDAANGKAPELGNASESGKIVFPSPDTITRQTLTDHMLTKGNPPLDLLVRTSGVERLSDFMLWQCDEDTEIVFLDVLWPEFDLWHFLPVLLSWQRRISKSKKNPDAEGNFDGDISENSDAELHSGGKVKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y741</accession>
    <name>B0Y741_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNF2 family helicase/ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_072480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072480"/>
    <dbReference type="HOGENOM" id="CLU_001592_1_1_1"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="PhylomeDB" id="B0Y741"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000871">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000059">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001870">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1252"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="749"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP49222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1483" mass="168051" checksum="CA960F44AE5A3C1B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y745</accession>
    <name>B0Y745_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ chaperone (Caj1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_072520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y745"/>
    <dbReference type="HOGENOM" id="CLU_073129_3_0_1"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="PhylomeDB" id="B0Y745"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000130">
        <property type="entry name" value="DnaJ chaperone (Caj1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="217" mass="23873" checksum="5B429663844F36D5" modified="2008-04-08" version="1" fragment="single">QPDYYKILGVSTDATQQQIRTAYKRESLKSHPDRVPADSPERPARTRRFQEINDAYYTLSDQTRRREYDALRAAEAYEEPAEEVPRGGGGGFPWSAFGFGTTTDSEQRASEQFGSVFEEMLREEGLAEDNSADGQRRTRPTSRFWSVVGGISGGALGFIVANTPGALAGAVAGNRLGAVRDAKGKSVYEVFLELPQSERARLLSELAAKVFQTTLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y758</accession>
    <name>B0Y758_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_072650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y758"/>
    <dbReference type="HOGENOM" id="CLU_007199_0_0_1"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="PhylomeDB" id="B0Y758"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="766"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="784"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP49239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="890" mass="97934" checksum="3094ECADE45DB404" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y818</accession>
    <name>B0Y818_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin reductase GliT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_075790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y818"/>
    <dbReference type="SMR" id="B0Y818"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075790"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="PhylomeDB" id="B0Y818"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000536">
        <property type="entry name" value="Thioredoxin reductase GliT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="334" mass="36004" checksum="6744C7C4CF119B84" modified="2008-04-08" version="1">MSIGKLLSNGALLVDVLIIGAGPAGLSTATGLARQLHTAVVFDSGVYRNAKTQHMHNVLGWDHRNPAELRAAGRADLTTRYSTIQFQNSTIEAIRQVETNQLFEARDNEGHSWYGRKVVLATGVRDIPLDIEGYSECWANGIYHCLFCDGYEERGQETVGVLALGPIANPARALHLARMALRLSESVTIYTNGNEQLAKEIQQAAEESPVGASGLKFEARPIRRFEKGDVAKTVIVHLGESESKTEGFLVYNPQTEVNGPFAKQLALNMTEGGDILTTPPFYETSVPGVFAVGDCATPLKAVTPAVSMGSLAAGGLVAQLQAQALPEFRLDQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8I8</accession>
    <name>B0Y8I8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol 2-monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_077490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8I8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077490"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8I8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF10">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="393"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="533" mass="58880" checksum="7B2AB9E10508F2DC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8J9</accession>
    <name>B0Y8J9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxy-cis,cis-muconate cyclase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_077600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077600"/>
    <dbReference type="HOGENOM" id="CLU_045869_0_0_1"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8J9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000244">
        <property type="entry name" value="Carboxy-cis,cis-muconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="377" mass="42291" checksum="A0AEE88ACCC93801" modified="2008-04-08" version="1">MKHHLVIGTWTPPGRLYTVAFDDEALTLELVKKTEIPEDEPISWLTISVGIQPLPATFANVVQHDKKTLYGAAMKKWNSFAINSPTDIVHQVAHPLAGHPLASSSESNTRAIFVLAAHKPPYNVYGAPFYNYAGYGNVFSVDPSDGRLVKNVQNYEYQENTGIHGMVFDPTETYLYSADLQANKIWTHRKDAQTGELTLVDCLEAPSPDDHPRWVDIHRSGKYLYALMEAGNRLAVYVIDEKRHVPVFTHITYPLLPAGVPPTNKYRGDVCFTTRSGEYLFATTRGTYGRPWTGYITAFKLGPNGNIERQLFIHPTSNSGGHSNAVSPCDFSDEWLALCDDQDGFVEIYRFKDETLARVARLDIPEKGFGMNAVWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8R0</accession>
    <name>B0Y8R0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_078230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8R0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078230"/>
    <dbReference type="HOGENOM" id="CLU_068979_5_2_1"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="194" mass="20904" checksum="58784D75207FAF2F" modified="2008-04-08" version="1">MLDLSLPTALVLIDNQAAFTHPTYWGTSRSNPAYETNLASLLHAFRTARKTNPTLPLEIIHVFHSSPSPTSPLHPADPSKGAHPLDFAQPAADNSEPVFWKNVNSSFIGTGLEAYLRDKKIRQVVFAGLTTDHCVSTTVRMAANLGVADVYPDGKPEILADGTQTVKPGFGREFEGGVCGGDDYEGGGRLARSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9T9</accession>
    <name>B0Y9T9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_082240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9T9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082240"/>
    <dbReference type="HOGENOM" id="CLU_017360_0_0_1"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9T9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="477" mass="52957" checksum="088A9A94FED9BB50" modified="2008-04-08" version="1">MSLRDLYQRFLANPKSVPLAANASLIYITTATQFDGADAIVSHLTKQETVVKKKAADIIDAIEGSNSLCLDVEVTLEFVSGGGAYLPSLDDNFLADRVAAFPTVDVIGARGRGWPIRDGKDQTRLIKAAVASTPASEGPAEPQPPQKENSEDFRSKSASPSKRHIKDPYAAESLEELLSPGKDRAQPVRAPRAPASAKPPPRDYSELFVGDDENDAPEPTPSKSRAIAPKAGAGKNYHASRIFEDDEAGAKQQIAYKTNPKRFDHFELGADNSEREVKSKPGRPMSRHVPHWDFEDFVTPEKPKRQPRPQEARHFGWSDDEVQPTPPVKPFVVQPRRDAETHFDLTDNDDEQHKSRIISSFQNKGLNLYKTHMYNEEESPGKNAAEKAPLGVVPNGGNRKKDFETHWSITGSSPADGKVSHENQKPMGTDRLKAVKMMEPSWEAYDESPQPSKTAPPPQRRPLRHVNEKHWDFGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAN7</accession>
    <name>B0YAN7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferric-chelate reductase (Fre2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_085300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085300"/>
    <dbReference type="HOGENOM" id="CLU_010365_2_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="PhylomeDB" id="B0YAN7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="8">
        <location>
            <begin position="288"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="710" mass="80301" checksum="93E3288887CE72DB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAQ2</accession>
    <name>B0YAQ2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_085440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085440"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="PhylomeDB" id="B0YAQ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="12"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP49095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="366" mass="39695" checksum="C15829D851349137" modified="2008-04-08" version="1">MSPSVSPNKTYNIAAIPADGIGPEVIGAGITALNALSETLNTFKLNFTTYDWSSETYKKTGKYIPDGGLDELKKHDAILFGAVGAPDVPDHISLWGLRLAICQPLQQYANVRPTKIFRGTESPLRRCKTGDLDWVIIRENSEGEYAGQGGRSHRGKAWEVATETAIFSRHGVERIMRFAFETAQKRPRKLLTVVTKSNAQRNGMVLWDEVAAEVARDFPDVTVDKMLVDAMTTRMVLKPETLDTIVATNLHADILSDLAAALAGSIGIAPTSNLDPTRENPSMFEPIHGSAFDITGKGIANPVATFWTAAEMLAWLGEEDAAKKLLNCVEDVCEMGILTPDLGGNATTREVTEAVVGQIRKLAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBQ3</accession>
    <name>B0YBQ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA exonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_087460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087460"/>
    <dbReference type="HOGENOM" id="CLU_644194_0_0_1"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="PhylomeDB" id="B0YBQ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000218">
        <property type="entry name" value="RNA exonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF114">
        <property type="entry name" value="EXONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="210"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="423" mass="47847" checksum="E7727FC1DBFF2BA3" modified="2008-04-08" version="1">MDQPVPRVELAFRPKESFAAPGSNIRKPEDQVDMTAENTELHATQHKAQAPIGGRKHTRPAAGPLKSSSKQEAPEQKEPVVHEWSDVPGPLHEAVIACLKRVCHDLNTLARSGYKVREMTKEDVKGYAKCRNCGERKRVLDTKSKTACFYHPMKLKHQKKQYKYPCCGKRHGCASLPAHVYAPVPGFILENWQSYQLTPSPMPGLRPPRRVVALDCEMVEVKGGDSEVAQVCAVDTLTGEVIVDIYVVPSKTVTDWRTPWSGVSQRLLEEMKEAGKTVNGWEEARKALWAHIDADTILVGQSLQHDLDVMRMVHLNIIDTAILSREAVAKNCKQNWGLKRLCKQMLDRDIQQSRGGHDCLEDTMATREVVLWCVRHPGKFQEWAVSQREWKKKADAHWKLKRKESDKAQVKQPQKSVSQVPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBS0</accession>
    <name>B0YBS0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytidine deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_087620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087620"/>
    <dbReference type="HOGENOM" id="CLU_097262_4_1_1"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000123">
        <property type="entry name" value="Cytidine deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="128" mass="13485" checksum="19363BC58F3B90A8" modified="2008-04-08" version="1">MPLTPEETTLVDTATSIITRIPVSDTHSVASAARSTDGRIFTGVNVYHFTGGPCAELVVLGSAAAAGATHLTHIVAVGNENRGVISPCGRCRQTLIDLHPGIQVIVLDQGEPRAVRVEELLPFAYLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC22</accession>
    <name>B0YC22_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AIF-like mitochondrial oxidoreductase (Nfrl), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_088630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088630"/>
    <dbReference type="HOGENOM" id="CLU_003291_4_2_1"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="PhylomeDB" id="B0YC22"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP48153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="558" mass="59835" checksum="C4EF7ABACB698F23" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCC1</accession>
    <name>B0YCC1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_089660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_089660"/>
    <dbReference type="HOGENOM" id="CLU_038839_0_0_1"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF32">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G04120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="358" mass="40280" checksum="A0952E0CE573E22B" modified="2008-04-08" version="1">MATDAMTRPISCLCGDAAQDVLLDSASDLSAFNLCHCIDCRAITGMLYSSYYFLQTPGPELDRLRKYQQSDCISRYFCRTCGAHVFARLEATGRTLVADGVLLEKPPPIRVIRHWKAEDTLDGGLSCFLAGDAKQTTSACWLDAEQDICNGHAEDNNNLEDQDHGVHRLQARCHCGGIEFYITPPDSDSAKPWSPWPDLIVPYHLTSPENFEDIKWWLRDGNTKYLVGTCACRSCRLASGFSIQSWAFIPRSNIISSDGKSLVYGAGTMQQYESRPGIYREFCNRCGATVFWHCQERPGVVDVSTGLLRARSGVKSEEWLEWATERVSFKEMALNREFIERLEEGLKNWGESKKDPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCI5</accession>
    <name>B0YCI5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_090310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090310"/>
    <dbReference type="HOGENOM" id="CLU_019189_7_1_1"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="PhylomeDB" id="B0YCI5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="142" mass="15726" checksum="2F1BBA0C2C57E9B4" modified="2008-04-08" version="1">MSKRYAKFDLDALCSLVSSLPSVSSPISKVEKMEGGFNKTLLMTAENRKGVLAKMPCPAVVPSRYSTASEVATFEYVKSLTSMPVPEVLTWSCDALNPVGNEYIVMEKAKGRQLVEVWGEMDQAQKFKLIQTLSGWKASWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCJ8</accession>
    <name>B0YCJ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_090440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_090440"/>
    <dbReference type="HOGENOM" id="CLU_004083_5_3_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="PhylomeDB" id="B0YCJ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="690" mass="76639" checksum="47C69403E4A6B3FC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD54</accession>
    <name>B0YD54_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_094320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_001147_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
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        <property type="entry name" value="Sec16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
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        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="196"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="893"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1070"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1420"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1509"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1692"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="814"/>
            <end position="829"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1428"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1513"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1550"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1725"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1737"/>
            <end position="1756"/>
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    </feature>
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        <location>
            <begin position="1757"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP47588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1832" mass="194986" checksum="C00563346EB8CB5E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDI7</accession>
    <name>B0YDI7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_095720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095720"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="B0YDI7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STKc_CMGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="53"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="342" mass="39047" checksum="56426ADA43F15C20" modified="2008-04-08" version="1">MNNVRRRRLSSRECSTVAHIIHTETPIEEETLPHYKAEHYYPVRIGNVYHARYKVAGKLGYRAYSTTWLCRDLQANNYTVLKVSTSLPDYPTAADRELRVYKHLAKIDSSHPGRSLIRELYDSFDLHGPGGTHRCLVLQLMNVTLLKMMRMNPRLFDLPLLRMTIKRLLLALDFLHTEAEVIHTDLMSNNLMLSLEDSSMLADFTTAETENPSPQKLINQSYIIYYSQNFRRPTGGRNYGLPVLCDLGEARIGKTQASGPFVQPHIYRAPEVIFEMTWGSAIDIWNLAGLIWDLFEGQHLFGDIFDAKGGHDPFRHLALMVALIGPPPTEFVRCSETTEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDL9</accession>
    <name>B0YDL9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_096050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDL9"/>
    <dbReference type="SMR" id="B0YDL9"/>
    <dbReference type="Allergome" id="73">
        <property type="allergen name" value="Asp f 3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096050"/>
    <dbReference type="HOGENOM" id="CLU_072440_1_1_1"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="PhylomeDB" id="B0YDL9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF30">
        <property type="entry name" value="PEROXIREDOXIN PRXA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP47753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="168" mass="18453" checksum="AFFCD72C5A1CCBB2" modified="2008-04-08" version="1">MSGLKAGDSFPSDVVFSYIPWSEDKGEITACGIPINYNASKEWADKKVILFALPGAFTPVCSARHVPEYIEKLPEIRAKGVDVVAVLAYNDAYVMSAWGKANQVTGDDILFLSDPDARFSKSIGWADEEGRTKRYALVIDHGKITYAALEPAKNHLEFSSAETVLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDX5</accession>
    <name>B0YDX5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_097130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_097130"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B0YDX5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="44"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="398" mass="44551" checksum="A5DF5669CBED1B00" modified="2008-04-08" version="1">MADFSQWMDAHETWATHNLAETCCASISLDDLLAFAGNKDRATLVDFSQKQTYGPIRGSDALRSNIAHLYRSDRCEPLSKDNILVTNGAIHANFLALYANVARGDHVICHYPTYQQLYSVPESFGAEVSLWRADGQNGWQVSLNDLRSLIRPNTKVIIINNPQNPTGAVLSREVLQEIVDIARQHGIIIHSDEVYRPLFHSLENGQDEPPSILSFNYEKTVATSSVTKAFSLAGIRVGWIASRSREIIEQCATARDYTLISVSQVDDRIATCALSEPTVSNILKRNLDLARGNLDLLDGFVREFAWATRWNRPHGGTTAFIKFVNKDNLAIDDVEFCTRLQKEFGVMFVPGSRCFGEDTNFKGYVRIGYVCERQVLIDGLEALRKFMADAYHSLPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEC0</accession>
    <name>B0YEC0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_098640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098640"/>
    <dbReference type="HOGENOM" id="CLU_490857_0_0_1"/>
    <dbReference type="OrthoDB" id="3557758at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="629" mass="70045" checksum="95C6370F8B7663C1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEM5</accession>
    <name>B0YEM5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exo-beta-1,3-glucanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_099700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099700"/>
    <dbReference type="HOGENOM" id="CLU_002540_1_0_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="PhylomeDB" id="B0YEM5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000043">
        <property type="entry name" value="Exo-beta-1,3-glucanase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760965" evidence="5">
        <location>
            <begin position="20"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="71"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="416"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="779" mass="82567" checksum="9F2A8D4D47C38AE4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEN8</accession>
    <name>B0YEN8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_099830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099830"/>
    <dbReference type="HOGENOM" id="CLU_1389911_0_0_1"/>
    <dbReference type="PhylomeDB" id="B0YEN8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="196" mass="22784" checksum="2B88353CCF596471" modified="2008-04-08" version="1">MEPPEGAADTTLTDQEKRGRRADERLPHFRQNLCIRARNQTQHHWARSVQQPNCLACLVPTLTYYKDHTMSHNDHRCGKNFLDWVNDSLPLDTILEFVSLYWFTKSFPRAIYPYREAPHDADAMHDRLYIQKPLGFSYFPNEIIPAPKAWVSTTGNLVFWRQHDKGGHFAALERPHDLKAALSAFVEQVWPEVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF57</accession>
    <name>B0YF57_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_101630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101630"/>
    <dbReference type="HOGENOM" id="CLU_085154_0_0_1"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758955" description="GPI anchored cell wall protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="20775" checksum="1795292276A818F1" modified="2008-04-08" version="1">MRASFLLPVAIYVLTAYADDKTTTVGYFIPSWSVTLLSYGVWTSTGASVAGINAAATTYHLGCLKDAPKTDCNIKNSWTIIQGPETVSATGVYTASTSGKETSYDITVTESYECKIRSRTESASCTMSVGMTGSVGGAAITSSTSTSATYSPATSSYYELVVTAGVDKFTVPEATKTPGVAAAGPAGALITAGPVVAAAVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YFB1</accession>
    <name>B0YFB1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_102360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499607">
        <property type="protein sequence ID" value="EDP47063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YFB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_102360"/>
    <dbReference type="HOGENOM" id="CLU_112519_0_0_1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="151" mass="16642" checksum="505CFEE4B9A7690A" modified="2008-04-08" version="1">MITEEVVKAAAGNEEGGERVMALLLEKRGGEVMISKEVVRAAAGNEWSGEKVLALLVEERGDEVMITEEVLKAAAGNEGSGEKVLALLEKSQDGMGMQAKDELIWIRKLQNMFRDALITTVLMNKSHQRTLKSGCQRRDRQLTTTGMLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMA9</accession>
    <name>B0XMA9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_000480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMA9"/>
    <dbReference type="HOGENOM" id="CLU_079426_0_1_1"/>
    <dbReference type="OrthoDB" id="2344312at2759"/>
    <dbReference type="PhylomeDB" id="B0XMA9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="151" mass="17675" checksum="7CA363564CCA702D" modified="2008-04-08" version="1">MSPRIEHQIHSIGKSYDESHLTLYITMSQIFSIWVVPFHVSPVRLTTVINLTTDSGVQKPSMVNGNHTLYYITKQEDLYQVSEWIKFLVPHVGHLFVLAFQSFATLFCLLGVVILYPIMWLEERRVIPYKILRKGNLVYNIERKIPEIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMC5</accession>
    <name>B0XMC5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_000590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000590"/>
    <dbReference type="HOGENOM" id="CLU_056023_1_0_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="PhylomeDB" id="B0XMC5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000756">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="409" mass="45379" checksum="AC2668859430B63E" modified="2008-04-08" version="1">MSDTIADEILRNGYAKTFTRHSVFLTGSTGSLGGCLLYKLALQLPTQKIFVLIRGSAESAIEKWRRLMPKQTQAILNTGKVHFVVGDIKKTDFGIEEAELSRLREEVTLVIHTAATITLDAGIVESIENNCLPSLELAKIVSRFRRLKLFLQISTAYVSSFLPDGYVGERVYSISDADPEDELAAILSTGNSLDTARFSSSYTHAKYLMERLLLKRYPLLPLLLVRPTIFGAAMRDPYPLYGPINSTPMNKFASLFFADRGGTHIWHATEGYETGANIVDEIPVDFVANGCLLHAASRTQGIVHLGAQLYVPFTFDDFLRLAEASAPPSIQKELPSLIFTQDRNAPQSLLADLVKVSTRNWVFDCGRSYWLKQMAGPLSLAACKHDVDALNSARIKEIYENTVKKLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XML8</accession>
    <name>B0XML8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_003200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XML8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003200"/>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="PhylomeDB" id="B0XML8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="203" mass="21825" checksum="CF891DA5765E023C" modified="2008-04-08" version="1">MAPKVAIVFYSMYGHILKLAEAEKRGIESAGGQADIYQIAETLSDDILARMHAPPKSSYPVVQVDTLKDYDAILFGIPTRYGNFPAQWKTFWDRTGGIWASGGYWGKYAGLFVSTGTLGGGQESTAIAAMSTLAHHGFIYVPLGYKTVFPMLANLEEIHGGSAWGAGTFAGADGSRQPTQLELSIAEAQGKAFYETVAKVNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMM2</accession>
    <name>B0XMM2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_003240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003240"/>
    <dbReference type="HOGENOM" id="CLU_067130_1_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="274" mass="30913" checksum="E56CABED09ABA731" modified="2008-04-08" version="1">MTLFTTNHQTAFAMSSHQYTLPGMHDVPETYPYHMSQVDSEEDMDSLYLSSAPEPSYTRLDFEPTIPAMPTSQAYNTTMRAPMSGSYLPYSDQWTSQVPPTAAAAPTTTLYHPTDIYPSSTMTYTPQRTAPTALNPNPQTYFYPDPSTNTNLDLDLKLPSSDLDTKDLTNYGIPNPDGSWSCAYPGCTSTATFHRGCDLRKHFNRHRKHLFCRHEGCPQAVTGGFSSKKDRSRHEAKHNPGVVCEWPDCGRVFSRVDNMKDHVRRIHKRGEVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMQ2</accession>
    <name>B0XMQ2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_013760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013760"/>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="PhylomeDB" id="B0XMQ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP56659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="312" mass="32572" checksum="B92B484604DA167D" modified="2008-04-08" version="1">MAFGGPRGGGRGAPRGGRGAPRGGGGRGGRGGLGSGGRGRGGARGGGRGGPARGRGGRGGGRGGAKGAKGGAKVIIEPHRHAGVFVARGGKEDLLVTKNLTPGESVYGEKRIAVESPAGEDGAVTKIEYRVWNPFRSKLAAGILGGLDDIYMKPGSKVLYLGSASGTSVSHVADIVGPTGNVYAVEFSHRSGRDLIGMATHRTNVIPIVEDARHPLRYRMLVPMVDVIFADVAQPDQARIVGLNAHMFLKNEGGVIVSVKANCIDSTAKPEVVFAREVQKMREEKIKPKEQLTLEPFERDHCIVSGIYKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMV5</accession>
    <name>B0XMV5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_003440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003440"/>
    <dbReference type="HOGENOM" id="CLU_096545_1_1_1"/>
    <dbReference type="OrthoDB" id="5597238at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760458" description="GPI anchored serine-threonine rich protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="17747" checksum="511069215F8C02E5" modified="2008-04-08" version="1">MKFNIIAVSSLLVLATAQSTTESAPSTTTSLSPEASCAAKCGSNDICCVAGCYNVPCPSDQQANDTISCVAACPQGSGTPSDTDKYAACQNSCYSSHFFPATMTNAGSAKTGVSSNTATTTGTGSSSSETGTSGSDSTASGSGTATSSSTATSTPNAAVVSQMQLGVSAAGLLGFVLAAWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN27</accession>
    <name>B0XN27_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_014360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014360"/>
    <dbReference type="HOGENOM" id="CLU_2527027_0_0_1"/>
    <dbReference type="OrthoDB" id="10485576at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="84" mass="9466" checksum="79D5683ACC81D066" modified="2008-04-08" version="1">MTIGHPQNPYQKWFSGHHRAEDSKHWLRFETLRPLSALRQDDSSPHCLVTPIIVTLQLPLVDHGPRRSDSSISSILSPVLSVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNE1</accession>
    <name>B0XNE1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane phosphate transporter Pho87, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_004620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004620"/>
    <dbReference type="HOGENOM" id="CLU_005170_8_0_1"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="PhylomeDB" id="B0XNE1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="730"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="846" mass="93545" checksum="B1AF6FC808727726" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNL2</accession>
    <name>B0XNL2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_015550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015550"/>
    <dbReference type="HOGENOM" id="CLU_008554_2_0_1"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="PhylomeDB" id="B0XNL2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070159">
        <property type="term" value="P:mitochondrial threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000023">
        <property type="entry name" value="Threonyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="95"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP56834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="535" mass="60152" checksum="7D325FAE36C725C7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP53</accession>
    <name>B0XP53_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphotase 2a 65kd regulatory sububit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_005980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005980"/>
    <dbReference type="HOGENOM" id="CLU_015533_2_1_1"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="PhylomeDB" id="B0XP53"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030952">
        <property type="term" value="P:establishment or maintenance of cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990813">
        <property type="term" value="P:meiotic centromeric cohesion protection in anaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="6">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="616" mass="69191" checksum="98F8817724D2700E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP92</accession>
    <name>B0XP92_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_016520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016520"/>
    <dbReference type="HOGENOM" id="CLU_090423_1_0_1"/>
    <dbReference type="OrthoDB" id="5281164at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="187" mass="21530" checksum="46F56DD3FE66DBB7" modified="2008-04-08" version="1">MPEKDTPRPKTTLLCLPPELHLLISTYLSFPAIVHFRITCAYLYSLLPPLTHAQLLLAETTEFALSKDIYACRYCLRLRPASRFADRMRRRRRGKFGRDAEKRFCVECGLQPRKGTDGEARYGPGAQMRIDGVPYVICITCRRFGPMYAGGILCQECGLERERVRRRELLLLKERELGLYPETTDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPA4</accession>
    <name>B0XPA4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_016640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPA4"/>
    <dbReference type="SMR" id="B0XPA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016640"/>
    <dbReference type="HOGENOM" id="CLU_106380_1_0_1"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="PhylomeDB" id="B0XPA4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013984150" description="Hydrophobin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="140" mass="14318" checksum="A74A0EC518354E1A" modified="2008-04-08" version="1">MKFLAVVSLLAATALALPNAGVVHPTFASADKYTLQQAQNKCGEHTTLSCCNHVSKVGDTTAFNYGLLNGLLGNAISGPEGVGILSGCQKISVTALIGVDDLLNKQCQQNVACCQDNKSVATGGLINIATPACVALDSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPD3</accession>
    <name>B0XPD3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI anchored protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_016940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016940"/>
    <dbReference type="HOGENOM" id="CLU_1034307_0_0_1"/>
    <dbReference type="OrthoDB" id="5320272at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760033" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="269" mass="29575" checksum="644661EB0BB1FE34" modified="2008-04-08" version="1">MRPQLLLIYAVLAGAETTATVDQSPQEHFGLHSQFIDELGATYNVFVKDFHGTHKIQYINSTDFIPTSHFVRFDQHPNLDERNVCRKVADCIGNSTDSAATWLEAKAAPTGQMCGSVATTLWNYLKADDYAVVKNLAWTAGSGIALNVIGNIPNYYINALLAKQSASGDPSDSCGQNADSTYASDAASSVYEFCLSIQTEKMENTATRFDAMDSRSSSTWPAGVQGMAKYFISQQAETWAPICAAYGITWKRDMLLRFKTLAASWFAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPH9</accession>
    <name>B0XPH9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_006540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006540"/>
    <dbReference type="HOGENOM" id="CLU_008827_0_0_1"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="PhylomeDB" id="B0XPH9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="85845" checksum="856DE092F8FA8252" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPN8</accession>
    <name>B0XPN8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_007040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPN8"/>
    <dbReference type="HOGENOM" id="CLU_1634988_0_0_1"/>
    <dbReference type="OrthoDB" id="5273928at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="162" mass="19022" checksum="44E28DF73D8B27D9" modified="2008-04-08" version="1">MSVRKLERKSGQVYEEQAMLPGLSYSMGPSWVHESPFCTVEPNPRHQKGAPSLKECAMEQLLSDQRNLTPELFSHIPWRMASKLWDHFGQRQRRTLYMWKLFATVYPAEFRCVAKYRCMKVKWPQMPLREYWSVVKSDTLSWRLVLTLSPSLGRIPELVGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPR2</accession>
    <name>B0XPR2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2 transcription factor Crz1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_007280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007280"/>
    <dbReference type="HOGENOM" id="CLU_014490_0_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="PhylomeDB" id="B0XPR2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="384"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="708"/>
            <end position="737"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
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        <location>
            <begin position="141"/>
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        </location>
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        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
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        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="279"/>
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        </location>
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        <location>
            <begin position="459"/>
            <end position="472"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP56026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="754" mass="81905" checksum="BBC9628267D3B26D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPS0</accession>
    <name>B0XPS0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein uS4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_007360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
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        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="term" value="P:ribosomal small subunit biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding S4 domain"/>
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        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="244"/>
        </location>
    </feature>
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        <location>
            <begin position="311"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
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            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="469" mass="52967" checksum="609466A9C45628A5" modified="2008-04-08" version="1">MRNRATTPLSKAKIRQSWSKYNLFNLSRFRAPPTANRTFFQQKWTAKSVARAYHGEQVRESQWSRMFTRRIRSVVPMSPEKLASDDGSAMSAGRGAGLESEASGDGTAGAQDQTSLTPYTQMTFAPLERRLDVAIFRAMFASSTRQARQFVVHGAVTVNGKKMRYPGYLLNPGDLFQVEPERVMYATGAPKDKFERRESRVARRKAAESNEGQTEEGMAAETENKKDESETTEAQDQQKDDPKETLKKLLTQAKTIMSDSKDVLPAKRKQELRGFQKAVRRVLSRSESSTVLTDNLESQFSELITLLKAKKAEKKEDNESKKTASTPAEETSTTTSESTDATTTTTATSVAENKPSDKLSEAFQKAAQNPEEEVDTSELTEEEFEVLRRALIQMRDNPIDHSKPYATPWRPRDYMSAFAFIPRYLEVNHNICAAVYLRHPVARPGRTEVPTPFNENISTAAFAWYLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPY9</accession>
    <name>B0XPY9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_008040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008040"/>
    <dbReference type="HOGENOM" id="CLU_034486_0_0_1"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="PhylomeDB" id="B0XPY9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="153"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP56103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="407" mass="45686" checksum="AC0E4699140C1A8C" modified="2008-04-08" version="1">MSSEDTISLGDQVHFEGNVSGAEFSKSTRRNPRNDAATGASAAGVRAVSAQMVAFYFRAPVKAFFRTRVDYMAFARAVNPHSAEKRWSLHTTTPGLLVHAVRTYGWRFIPNQLLPPMLANAGVGAVLYTSYLQALGILYEPVSRSVKRIYPPASPVDTFAAGFAAGTIQSVVAAPLDALHVRLRTNDMLHGQYRSMWHYGQKKLKEIGLRGIFAGWSLSLVRDSFGYAVFFSTFEYIKSQAYYSFITRYYGSLHTHQLDSLRDPQSSDRGVPLIKPHYSLEPCFLMLAGMAASIAQQAVQHPLSAIQNIHYSRLEYLDHQANLISTKGQMMQVYYSAYQETFKRCRRRAARAGGWRKWLFQGFVGNALRQVPSTSAGLVIFELVRRKYANMADAIYIRKDGYDILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQA0</accession>
    <name>B0XQA0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">La domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_009220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009220"/>
    <dbReference type="HOGENOM" id="CLU_005100_0_1_1"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="PhylomeDB" id="B0XQA0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="605"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="786" mass="83726" checksum="F5B4DFA3CC2D6B44" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR73</accession>
    <name>B0XR73_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetochore protein fta4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_012350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012350"/>
    <dbReference type="HOGENOM" id="CLU_058478_1_0_1"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="PhylomeDB" id="B0XR73"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27205" checksum="1C65DC1198813893" modified="2008-04-08" version="1">MDASRTVFELKLAFIRAQVRILSESLEPPENWRIYATESEEDELSDKAVQDALQKLNGALKKHNRIIYSSQAIQHVAQQITSLYWSLLSHATHNVGISDKRLETTVDLCSHFDITQLPAELEDQHASEEERLRYQELRERLMRLDTERQQRQRRLGQLRRLHKLLEPFSEPQNNIQPNLVTRDGELVQELEKMRMLVARVSGRIEQSKERSTSSEGSPPYAFGADEKLAALLDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRA5</accession>
    <name>B0XRA5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper-activated transcription factor GRISEA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_012670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012670"/>
    <dbReference type="HOGENOM" id="CLU_561459_0_0_1"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="444" mass="47401" checksum="21321404FCF996C9" modified="2008-04-08" version="1">MGEHVPAPNPLSVPPMTPQLPSTGDSQQCERRAGTFQSPGNFASGFTTVSGFENKHGENGVFSHLPPYPSYDSGLGIASNSSGVANSGFITPPTFMAQQAFDNVSSSGSQKSSCCSAKTPTTVPAPTQSSFCQKNDSPMNSQTASYQPYSDGAMYPPTSTRQNSSWQHFYTAGQNNYSSHYPLQNQTLGQPAVIPNYIPQPAVDYSKPSFSQHNVANGNAFFHGTLSQPTSGQTQTLGPPHTTFSGEQKHDCNCGDSCQCLGCATHPFNSTTRQHVQEMGLLVTLDGEESSFEHLNGYRNLQSNDNPDATPFNYNLTNFSHFGHENHSEAIHNTDNTSPNGSSPSTEYPSEQHLMVPSEYYTIEYPVQLPNACSDVTGSCLCGNDCACVGCLTHSGHNGFAVESSAIENNNLSPSSPSAKHESVGSPLVPGHTHATVQSPNPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRJ3</accession>
    <name>B0XRJ3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002670"/>
    <dbReference type="HOGENOM" id="CLU_019222_0_0_1"/>
    <dbReference type="OrthoDB" id="5395390at2759"/>
    <dbReference type="PhylomeDB" id="B0XRJ3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="704" mass="80871" checksum="47B977DCE755EE18" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS13</accession>
    <name>B0XS13_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_025560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025560"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="PhylomeDB" id="B0XS13"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="118"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="478" mass="53741" checksum="69272B48A3C9D4BB" modified="2008-04-08" version="1">MSAPTKSRWAAEDPEDDAIIAQRKREKEEKRRAKAEKQRQLEEQARLQTAQAKQQQQADALNGDSEAPPKKRRRLSNEQPQTSAVSESAAKAPAEQTRSTLLRFPGPGWGPCRLVDNFERLNHIEEGSYGWVSRAKDITTGEVVALKKLKMENSPDGFPVTGLREIQTLLEARHTNIVYLREVVMGTKMDDVFLVMDFLEHDLKTLLDDMREPFLPSEIKTLMLQILSGVEFLHSHWIMHRDLKTSNLLMNNRGEIKIADFGMARYYGDPPPKLTQLVVTLWYRSPELLLGAEKYGPEIDMWSIGCIFGELLTKEPLLQGKNEVDQVSKIFALTGPPTQQTWPGFRSLPNAKSLRLPPTSTSGLTENPPLLPRSKFPFLTNSGLRLLSSLLALNPSARPSAQECLSHKYFREDPRPKPKEMFPTFPSKAGMERRRRRETPEAPKRGQEAPALDFASVFGGQSSGDTGETGAGFTLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS59</accession>
    <name>B0XS59_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_026030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026030"/>
    <dbReference type="HOGENOM" id="CLU_050259_0_1_1"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="PhylomeDB" id="B0XS59"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="315" mass="36891" checksum="544AC0FD96952D44" modified="2008-04-08" version="1">MAPVAMSSEPAVFNTKRDGHALEDLSDAIDTVNLLKNEMKKERGLYDESEFDKNKDKTQFRQYEDACDRVKNFYREQHTKQTVAYNLKARNDFHSKTRAEMSIWEAMEKLNTLIDESDPDTSLSQIEHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLLYFFDAQGQWDVVGDTFPVGCAFDDRIIYGKESFKENPDYEHEIYGTKYGIYTPGCGLDNMMLSWGHDEYLYHVVKDQSTLPDEALAMIRYHSFYPWHQAGAYHEFMNEKDQKMLQAVKAFNPYDLYSKSDDVPSVEELKPYYLELIDEFFPKKVLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSA2</accession>
    <name>B0XSA2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS phosphate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_026470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026470"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_13_1"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="PhylomeDB" id="B0XSA2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="666" mass="74948" checksum="FDF89643E6B66A93" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSC1</accession>
    <name>B0XSC1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor Rrn11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_026660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026660"/>
    <dbReference type="HOGENOM" id="CLU_027162_1_1_1"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="PhylomeDB" id="B0XSC1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50071" checksum="DD4D53B6D98B2CB2" modified="2008-04-08" version="1">MAFVPSASAFSLPLPSWQQPASVRVARYEAKKRKKHSDDWGADNGDGEGETTDGASEIAPIAPSLTLSPEEAHQYRVAGLSFDQELPGGLFPHAPAKSELPKKENRGDILESLSSLSPPIYPPQSSAYQGNLRLQHLAVITSILHRCLLQGDYIRAGRAWGLILREEFAGSPIDVRTDGRWGIGAEILLRRGRQAAENAPGIQPTGDGHESGGGHVSRPYFTRKGFEDAKHYYERLIVQHPYRKSAPDAICSLHFYPAMFGLWIYVVQEESTLAREDIHSRHEDSPGDFSEDEELGQVSDGESVSKHRKHHLITSVRARELEEAQQIAARMDEILVSPPYSDSPELLELRGMLSLWIGDLFVSCVPHQEEDEYDSDGRSSVREDTDHLHDSIQARRERRLAMEKRQSEILKSREFFEKARQRGRSVASTLEHFHIDDSASMASSGMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSI9</accession>
    <name>B0XSI9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_027350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSI9"/>
    <dbReference type="HOGENOM" id="CLU_035117_5_1_1"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="PhylomeDB" id="B0XSI9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="161"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="295" mass="31265" checksum="2D9FB182BA1185B0" modified="2008-04-08" version="1">MSKNIAQKGPQSSLTLYNRTVAKASAFAESLGSTQAPVTVASTIPEAVKDASIIFICVADDPALDQIISTILADSSLNLASKVFVDCSTVHPDTSRRTHAALTPRGASFIACPVFGAPVFADAGQLVVVPAGDAAAIDRIRPFFEGVTARATIDMSGHDVGRASTLKILGNTLILNTVESIAEGLVAAEKFGLGADVYQQWVHGLVGGMFAKYADRMCTGDYYKREEPLFAVDLARKDLRHAASLAEAAGMRLRSVEITDAYLQEVKAEKGEKGDIAGVYGAIRKESGLPFENQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSJ6</accession>
    <name>B0XSJ6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_027430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="B0XSJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027430"/>
    <dbReference type="HOGENOM" id="CLU_013984_0_1_1"/>
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    <dbReference type="PhylomeDB" id="B0XSJ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16151">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16151:SF2">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="75"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
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        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="642" mass="71398" checksum="D99BA7736CF349A9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSU3</accession>
    <name>B0XSU3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_017620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EDP53720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1749185_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="149" mass="17453" checksum="E1263ECCF96AE144" modified="2008-04-08" version="1">MRESSCIMRISFTDTCHRCGAVVRGLGGNQVGQRIARCHYVVTFVEEYNSRLHSARDKYWDAVTETWCVDGRMKWYIEKGKPISEDEPIRMSWHQHVSKSRSLRGLHLEGRPQRNTTVLIPQLHQFLGADILRCCFRDCHDVYFGVYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT03</accession>
    <name>B0XT03_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_028410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028410"/>
    <dbReference type="HOGENOM" id="CLU_003826_2_0_1"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="PhylomeDB" id="B0XT03"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="294"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="946" mass="103310" checksum="BD1FC1B019195DCF" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT16</accession>
    <name>B0XT16_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial AAA ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_028540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028540"/>
    <dbReference type="HOGENOM" id="CLU_004223_1_0_1"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="PhylomeDB" id="B0XT16"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
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    <dbReference type="InterPro" id="IPR056027">
        <property type="entry name" value="DUF7608"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
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    <dbReference type="Pfam" id="PF24581">
        <property type="entry name" value="DUF7608"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        <location>
            <begin position="394"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="952" mass="105048" checksum="4C9F6F926258D122" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT17</accession>
    <name>B0XT17_ASPFC</name>
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        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_028550</name>
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    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EDP54795.1"/>
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    <dbReference type="PhylomeDB" id="B0XT17"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
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        <property type="entry name" value="Gag1-like_clamp"/>
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        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FREQUENIN"/>
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        </location>
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        <location>
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        </location>
    </feature>
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    </feature>
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            <begin position="352"/>
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        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EDP54795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="376" mass="40927" checksum="BC946BD80C8982ED" modified="2008-04-08" version="1">MSTEARDAAIREAKRHVFEVVRNDWAFEPSSVTSGAPASATPEAPEQQWLEWRLREYDSSGSELEPQGEPDSPGRQDGDSSDSSRVVTARERRRKRRRQLEEDEMRWNIGLRTWVERRDAWTGARSKEEVLATEDRERGPAVHSPGEAQDTGDTRDSTADLVARTGSSLAIAEKEGELRQSQTDQAVDEAAKESTETGLVVPDPESSHNESVCPQPPPPSAGEVRDPVIPVAPSFIPVSNPVRASITPAMYPSIYSKVVVQALTPTIPINLADVVKAMVQGWKSDGQWPPKPTSIVLPDDSIVHKNGSAAGDAQGPHESKRRSSVVGAVKKVFHFSGFHANPFHRRGSSHGSHPEAHDGQPKDGGPDPLGAEHPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTI9</accession>
    <name>B0XTI9_ASPFC</name>
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        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="4" type="ORF">AFUB_018740</name>
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    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
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                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
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            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EDP53830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="724" mass="78679" checksum="0E163AE3BE257DA3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTJ0</accession>
    <name>B0XTJ0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_018750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018750"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B0XTJ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="41"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="464" mass="51524" checksum="6AB6F148C9057DA3" modified="2008-04-08" version="1">MFAKVIAQILRSGRVQGDKHREIRLSLGISELFVSEQAHLHIIIAGAGLGGLAAAVSCALAGHTVEVVEQAKELVEVGAGLQITPNASRLFEYWQLPNSIWQAAAEPTALTVHRYTGPILANEPVFHKNIRAKYGAPFIDLHRVDLQQALFTRAKELGVTFHLNERVDSIDFATTTVQTLAGNRYTGDLIIAADGLWSRCRECFLGKKDAPLPTGDLAYRIVLTADQISDPELRAWVENPECHFWIGPGAHAVAYSLRNGRMFNIVLLVPDNLPPRVSRQSGSVEEMRKLFEGWDPVGDACHPMLPYLAQGANSSLEDGAVLGQLLGHMKNKSHLPQILRLYESLRKSRGEAIVKETFKQVSLPSHSVHCRALTFFSDMISTCQMARNRKREMRSSCLNSERRLRARFPVDGECSTLCGTVSRSHDTRTCPEVQPWLYGYNAIKEVEKAVMQHPELFARTAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTN7</accession>
    <name>B0XTN7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar sorting protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_029380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTN7"/>
    <dbReference type="HOGENOM" id="CLU_016678_3_1_1"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="PhylomeDB" id="B0XTN7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP54879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="666" mass="74202" checksum="017565D036324F0F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTX7</accession>
    <name>B0XTX7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UDP-glucose:glycoprotein glucosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_019450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019450"/>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="PhylomeDB" id="B0XTX7"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002757886" evidence="10">
        <location>
            <begin position="28"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="275"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="411"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="667"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1188"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1463"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1469"/>
            <end position="1480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP53899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1487" mass="166570" checksum="D622574EDB3976D7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XU15</accession>
    <name>B0XU15_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_019830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XU15"/>
    <dbReference type="HOGENOM" id="CLU_033337_0_0_1"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="PhylomeDB" id="B0XU15"/>
    <dbReference type="PHI-base" id="PHI:123465"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="481" mass="51550" checksum="D7505A01C0B62573" modified="2008-04-08" version="1">MNDRLEMTALTDVPAPYLKELSLSRPLPQSTPRHHAHSISLGAVNHNHRVTRRKSVTTTAAANAAAAVAASMKDTNGEPIGVPMPSHRRSSTRRGLESTSVGAPSGFGHYLSRSMNSPSQEPAVARKPSPNHSNIGASSVAAAGGEESSSDNKPVNTKSRNRRASEGSHLVKGEGKRALAELRCDRCGKGYKHGSCLSKHMWEHDPAWAITSKLLISKHQQVQLLEAASVLVNMNQHAPSESAEAESDQSSASPDTSSELRDGISSAETTPPPMDEDDENEEDMEMSGMPVFPNKRYSVGNVSAQYSHSYQSVPSSSFNGDAPLHSPAFSHFRHSSIDTRPSTAEAKLHEDDEADLAAAIGLCNFGTPRTGPVPMSPGIPPVPPLPSRYLDLSNGTGSISQSLDPAATVNATSSLTESTPNIFLSVSYNPSLSYKISDEREVKMGDADRVQRQNRNADVDFSNRPAHADDDDDGVFGRMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUM0</accession>
    <name>B0XUM0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gamma interferon inducible lysosomal thiol reductase (GILT)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_031360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031360"/>
    <dbReference type="HOGENOM" id="CLU_072148_2_0_1"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="PhylomeDB" id="B0XUM0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34711" checksum="AE440478D61E6ABB" modified="2008-04-08" version="1">MEKVQFQDQKGGLHDLGAVESGEAASSHSRCNRPASHFLRRSLMVISLGFALFSVLNWLPTPVPKFFLHSCRPSSKRLDDGFSVSPFTGGDVVPLTENKPEASVGDNKVLLEAHVMSKCPDARDCLQKLVVPAMEQISDKVDFGLAFIASVSNKSTDVVCKHGPAECIGDMLILCAANLPFPPEGRSMPRTPTIRSLGFANCLISSYEKIPERSFVEQCALEHGIDFDALNECASQQNDDPGHHGGDKDPLSGIALLRKSALYSEALGVRTSCTVRLDEQVWCVRDDGLWKDCAQGGRGSQISVLVEEIERIWRERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVM5</accession>
    <name>B0XVM5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_032970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032970"/>
    <dbReference type="HOGENOM" id="CLU_2960302_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="59" mass="6314" checksum="49D81CD8641D1E9A" modified="2008-04-08" version="1">MVIVRMLVRVCAIRLSILPQRTVLRFQQAGYLCDDDPRAALGSTVPAGSGDCAPERAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVN2</accession>
    <name>B0XVN2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_033040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033040"/>
    <dbReference type="HOGENOM" id="CLU_1372554_0_0_1"/>
    <dbReference type="OrthoDB" id="4385095at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="199" mass="23083" checksum="7F924A2BEE8F8C7E" modified="2008-04-08" version="1">MVFYAYATSGGFSVWLITAKDKDTLDAWFRAMETSQFGNIARINAEWYRYQNFRIEHSTTDYCLTQRFDGLILFKPLYYIRSKKSKSLYWDVKRKSEAESLQVYVSTKSRARFQAIKILCPNYAPSPVDHRILGDDRMSLHHAAGPVSFIRNDMGFLILTISCLNPHFRISELTTSFASQPDNRIAYIPGFGAEWELVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVP4</accession>
    <name>B0XVP4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_033160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033160"/>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="PhylomeDB" id="B0XVP4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="78"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="474" mass="51615" checksum="446436890D3DA878" modified="2008-04-08" version="1">MMLDGVPQPPEPIEAKQNDQEKALDDGADLKPIDNTPYIDPFGDEQNAEVKYKTLKWWTCAGNVECVSYGMGKRSSRLMIAESVSLGVLSLPATLASLGLVPAIILIVGLGILALYTGYTIGQFRQCYPHIHNLADAGEILMGRFGRELFGLGQILFSIFIMGSHIVTFTVMMNTITDHGTCSIVFSIVGMLICMVLSLPRTIKNLTYISFASFLSIFSAVMITMIGVAVQFKGGSNISVTAETNLYHAFTGVTNIVFAYCAHVAFFGLIAEMEDPKEFPKALCMLQFFEIALYVTAAIVIYYYVGNDVVSPALGSAGPLLKKVAYGIAIPTIVGAGVVNGHVGLKYIYVRIFRKTNRMHKRDLVSVGSWIAIGLSCWIIAWIIAEGIPSFTNIVSLISSLFASWFSYGLPGVYWLHINWGRWFSSPRKICLTIVNLLIVCIGATMCGLGLYVSGKAIHDDSSNTSFTCANTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVY0</accession>
    <name>B0XVY0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Actin-like protein ARP4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_023190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family. ARP4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVY0"/>
    <dbReference type="HOGENOM" id="CLU_027965_6_2_1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="PhylomeDB" id="B0XVY0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000137">
        <property type="entry name" value="Actin-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000063">
        <property type="entry name" value="Chromatin remodeling and histone acetyltransferase complexes subunit putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000224">
        <property type="entry name" value="NuA4 histone acetyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="466" mass="50720" checksum="E114C5E4B89E9221" modified="2008-04-08" version="1">MLIAICVQDEISAIVLDPGFSTTRAGFAGEDTPKSVIPTYYGKYTYEAQEKLIFGDDIFVTPRPGLSIHNPMGRDGVVEDWDMAEKVWEYSFTSRLTGPKAGNPFQNGLNDVANGELPSEMEGVETEEKPLADSPLLMTECGWNPTKAREKTVEIAMEKWGTPAFYLARNGVLAAFAAGKASALVVDVGASNISVTPVHDGMILKRGVQHSPLGGDYISSQLRALFKTNSPQPITITPHYLVASKTAVDAGQPAQAKYKTFPPDKAPDASYRTLMEERTLSEFKECVVQVWPGPNKLSATGPNGVSNEEVAKSSPGRPFEFPDGYNQVFGIDRYRVVESLFDAKAAIPDPESVFPVPTQAQTVPELIKAALNGVDVDVRPHLLANVVVTGASSLLYGFTDRLNQELMQSYPGPRVRISASGNTAERKFGSWVGGSILASLGTFHQMWISKKEYDEHGPNIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWE5</accession>
    <name>B0XWE5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamin GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_035610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035610"/>
    <dbReference type="HOGENOM" id="CLU_008964_7_2_1"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="PhylomeDB" id="B0XWE5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="46"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="628"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP52398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="712" mass="80420" checksum="0A65AE30E467BAB2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWG9</accession>
    <name>RSSA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">40S ribosomal protein S0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rps0</name>
        <name type="ORF">AFUB_035880</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with rps21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWG9"/>
    <dbReference type="SMR" id="B0XWG9"/>
    <dbReference type="EnsemblFungi" id="EDP52422">
        <property type="protein sequence ID" value="EDP52422"/>
        <property type="gene ID" value="AFUB_035880"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035880"/>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="PhylomeDB" id="B0XWG9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000371620" description="Small ribosomal subunit protein uS2">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="297" mass="32122" checksum="0A4900D405A6BBC2" modified="2008-04-08" version="1">MAPSQLPPIFNPTPQDIEMLLAAQCHLGSKNLQVHMEPYLWKTRPDGVNVINIGKTWEKILLAARIIAAIENPADICVISARPYGQRAVLKFASHTGATAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTEFVDVAIPTNNKGRHAIGLIWWLLAREVLRLRGTLATRETEWDVVVDLYFYRDPEAEENKEIADEAKVPGAEEIGAGAVESGFAGENWDTQAPGAGVPGTAFSAATAAPTSWEADGGDWAASSAAPAGESWAETQPAEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX54</accession>
    <name>B0XX54_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_047790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX54"/>
    <dbReference type="HOGENOM" id="CLU_005049_1_0_1"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="PhylomeDB" id="B0XX54"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="388" mass="43938" checksum="E81A28EBED59D7B8" modified="2008-04-08" version="1">MASSTNSSKHILTMSGVKRYSPKRLIVCCDGTWQDSLADGAQPPSNLTRFSRALSRLAVVDGEDGQQYEIPQIVYYQKGVGTSLGDKYWGGVAGLGVSANVRAAYGFLADNYNDGDKIYFFGFSRGAYTARAVAGLVCKWGLLTPRGMDNFALVYDDFYNQKIEGYDAERRKRMGFRDPLPRFTVEIIGVWDTVGFQKAWLGRDAGEKLELRNTILQDNVRYAFHALSLDEERTAFQPIVWHIPHRNEGQEMLQCMKHRQLRFDIDEYLFDDPPRPEESEMAPWATSLGKIDHSSIGRTLQGKLGGRSTRKPMGYNPTGQESDITNEFIHESVRDRNLAKWPCAALKGRHDEKSWTLTSGKQIAELPALQMEKYMKGRIRTVHVTEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX70</accession>
    <name>B0XX70_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin containing amine oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_037030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037030"/>
    <dbReference type="HOGENOM" id="CLU_004498_7_1_1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="PhylomeDB" id="B0XX70"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="507" mass="56053" checksum="418BFBA16A606FF9" modified="2008-04-08" version="1">MALKLPSLRQEIDSEGGCVHRHVDHHKSVTDFEQVHQTKIGDHLIDLGPNWIHGTEKNPITGVAEVTGTTIEDFEGEQIIFSRAGKLVDEATSARISEFVWSTIDEAFEYSNALKDSIPPDQSLLDFFKERVSKTGLNPEEKELCIETCKLWGAYVGDSIERQSLKFFCLEECIDGNNFFVASTYKKILDHVSEAAIQHADIRLNQPIIKIETNFRENSSAARRVILTTAAGESHQFDEVVVTCPLGWLKRNKSAFQPALPARHLQAIDSISYGRLEKVYVTFPRAFWHADAEAGLNGPDPKGTANHNPTFAVFHDPTYAEHPPDILWNQECISFAGLPGDCAHPTLLFYTYGPCATYIVSKIANLDPTTDEYYNFLDGFLRPFYSRLHGYSASSADCKPLAFVATQWQNDPYAGNGSYCNFQVGLEQGDKDIEALRGAIGPERGVWFAGEHTAPFVALGTSTGAYWSGERAAGEICRFHDLGRLGIGAGRDDSLPSAVPRKVASSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXE7</accession>
    <name>BGALE_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-galactosidase E</fullName>
            <ecNumber>3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Lactase E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lacE</name>
        <name type="ORF">AFUB_048070</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXE7"/>
    <dbReference type="SMR" id="B0XXE7"/>
    <dbReference type="GlyCosmos" id="B0XXE7">
        <property type="glycosylation" value="13 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP53621">
        <property type="protein sequence ID" value="EDP53621"/>
        <property type="gene ID" value="AFUB_048070"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048070"/>
    <dbReference type="HOGENOM" id="CLU_005732_2_0_1"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="B0XXE7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000088">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.390.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395242" description="Probable beta-galactosidase E">
        <location>
            <begin position="20"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="759"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="913"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="267"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1011" mass="111734" checksum="6312E4B521800294" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXF1</accession>
    <name>B0XXF1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_048110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048110"/>
    <dbReference type="HOGENOM" id="CLU_025694_1_1_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="PhylomeDB" id="B0XXF1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF35">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758000" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP53625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="456" mass="50246" checksum="096931CE7E299169" modified="2008-04-08" version="1">MRMLSLRQLCGATTLLLSGQVALADLGIQADNVDSLKSAAKTVAAPMMDFYDKNQTEGIPGKLTGTWYVAGAMFMTLIQYWQSSGDDTYNSIVSHDLMFQSGENYDFFSGNYSQWLGNDDQMFWGLASITASETGFPEISGKPTWTSLARVVFNMQVARWDKVACDGGMRWQIWPYQAGYTMKNAISNGGLFELSARLARFTKNETYAEWANKIWDWSASTPLLQTDRWYIADSTSNEANCKDAGNTQWSYNYGTYLSGASFMYNYTNGEDKWLKRVNGLLDSLIGTFCPKDKGGNVLSEVACEPIMTCDRNQIGFKGYTAMWLAHTAILVPSTAARIFPVLQGSALALSKQCSKAPDNTCGVRWWQPTWDGFTPGLETQMAALAGITANLMYYKSSAPKTIQSNPDGKEHQIDTHEDEAPDALAPINTGDRAGAWILTVIIVVAVGGSVGWLIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXI0</accession>
    <name>B0XXI0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_048400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048400"/>
    <dbReference type="HOGENOM" id="CLU_015282_2_0_1"/>
    <dbReference type="OrthoDB" id="3544487at2759"/>
    <dbReference type="PhylomeDB" id="B0XXI0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="593"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="100003" checksum="A5D3BEF17BCBB1A0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXP6</accession>
    <name>B0XXP6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_038140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038140"/>
    <dbReference type="HOGENOM" id="CLU_1626639_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="163" mass="18465" checksum="0B9835F8FC25AFF1" modified="2008-04-08" version="1">MSRWLPGVVVTERHARSKTPVLGRARGLVSPRLGTGPVGKEQRGLTGKKRHREKGPIEKSRRKILPGPKPMARGLKIDDEDGHFCMRISARTDEVRSNVKAERLPQFQTNCAVRGQQTIITNNNSIALLVEKKKDNRTNTFVGQIMQQPIQMQQHMTSPERRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XY60</accession>
    <name>B0XY60_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory factor Sgt1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_039750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XY60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_039750"/>
    <dbReference type="HOGENOM" id="CLU_006241_2_0_1"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="PhylomeDB" id="B0XY60"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="615" mass="69890" checksum="07E3174AF71F1750" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYA1</accession>
    <name>B0XYA1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">AFUB_040180</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYA1"/>
    <dbReference type="MEROPS" id="S53.010"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040180"/>
    <dbReference type="HOGENOM" id="CLU_013783_3_0_1"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="PhylomeDB" id="B0XYA1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF32">
        <property type="entry name" value="TRIPEPTIDYL PEPTIDASE SED3 (AFU_ORTHOLOGUE AFUA_3G08930)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760554" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="25"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="209"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP52847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="596" mass="65279" checksum="8DA994D7210D7FCD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ68</accession>
    <name>B0XZ68_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_043340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP53164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ68"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="188"/>
        </location>
    </feature>
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            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
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            <end position="246"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
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        <location>
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            <end position="348"/>
        </location>
    </feature>
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        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="484" mass="52285" checksum="2F697130080F531B" modified="2008-04-08" version="1">MAQDHTPDAVPVNEKDPPNQQLDDTTSDRFVPLAGFPRDEESGVNNGVDPRSKSLSRTATNTSHIGTLAARTLSLVRTRESGKDIGPPPDGGLFAWTQVLLAHFVIFNTWGYINGFGVFQTYYTEHLGRPPSDISWVGSIQIFLLFFIGTLSGRATDAGFFKVTLATGALLEVFCIFMTSLCTEYWQLFLTQGVGQGIGCGLMFCPTVALMATYFTTKRALAIGIVACGSATGGLVFPAVVVRLLPQVGYAWTMRVLGFITLATLLPPVVFLKQRLPPRKSGPLVEWAAFKELPYLFFAIGMFLNFWGLYVGFFYIGSFGRNIIGVSETTSVYILLVMNGIGILGRLMPNTMADWYTGPLNMLIPFSLVTGLVSFCWAGVDEIHGLYAWSAFYGLAAAGIQSLFPATLTSLTTDLKKAGVRMGMVLSVVAVAALIGSPIAGALVQTAGGQYLYAQMFMGSAILAGTLTLIAARVAKLGFTWHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZL5</accession>
    <name>B0XZL5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_044460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044460"/>
    <dbReference type="HOGENOM" id="CLU_010595_2_4_1"/>
    <dbReference type="PhylomeDB" id="B0XZL5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP53274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13739" checksum="1C13EF67C2CEB94E" modified="2008-04-08" version="1">MGKASLESGDRFDKTLRIVDESKQRMVDTGFVEVVERRYKLPIGLWSKDKHLKTLGKCFRLVIEESMEMWVMYLWTQVLGLTPAEVEMTIAEMRKAVRHPSIHGYIHVSVVYGRKPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZL7</accession>
    <name>B0XZL7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siderophore esterase IroE-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_044480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZL7"/>
    <dbReference type="SMR" id="B0XZL7"/>
    <dbReference type="ESTHER" id="aspfu-q4wf29">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044480"/>
    <dbReference type="HOGENOM" id="CLU_039834_3_0_1"/>
    <dbReference type="OrthoDB" id="446683at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052558">
        <property type="entry name" value="Siderophore_Hydrolase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841">
        <property type="entry name" value="SIDEROPHORE TRIACETYLFUSARININE C ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40841:SF2">
        <property type="entry name" value="SIDEROPHORE-DEGRADING ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="292" mass="32681" checksum="A9744D169390F7A7" modified="2008-04-08" version="1">MGDRPTPVPLPNSEQFYLENDRGEPYLIQVSWPLHWEDKQTGRGPLPIIYIVDGNALFLTATEAAWRRAAASHFAGGGIIVAIGYPLKGKLYDARRRSFDLTPPTACAPVGYGGADVFLDFIENSVRPAVQARFPQVSLAREALYGHSYGGLLALHALFTRPQSFDCYIASSPSIWWNSLCILHEAKAFVETKKVSHDQSPSLMVSWGSWEQHPPRWADELLDHYEARKRTAAELRMADNALDLCAMLHGCSRLHALIKTEYEGEDHTSVMSCSVSRGLTMFFEDWPFHQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZR7</accession>
    <name>B0XZR7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_045000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZR7"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B0XZR7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000034">
        <property type="entry name" value="Aldehyde dehydrogenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="510" mass="54848" checksum="850C1A2DDA590C8E" modified="2008-04-08" version="1" fragment="single">PKDNHLVLPRKTTTMSDVPHVSNWVNGTHTPPTPERIVVLNPATETPIATIDATPQATVQAIIATSWETFHGGSWSRADASDRFAVLSKAAALLRARIPEFVELETRQTGRPIREMRAQLARVPEWLEYSASLARVHEGRVTPFKGPVVNTLTRLPLGVVAQITPYNHPLLIATKKIAAALAGGNVVIVKPSELAPLSVLRLGPLFQEAGLPDGVLQIVSGYGSETGKSLCESRPLAKIDLTGGLATYKAIAPAAAANMIPITAELGGKAPVCLFPSLDVELAVKAAMFASFIASGQTCVTGSRLLVHADLYDRFKDLLEKRVRALRVGDPMEERTQIGSVISRAAVERCSAFVLRAVQEGGRVLCGGNPTNSNGKGFFFEPTIIETHADSDLATNEVFGPVIALVRCESEEEIIRIANSTSYALGASVWTNDFSQAHRVAAKIEAGIVWVNGHHLNDPSSSWGGFKESGMGKENGIEAYESYTKVKSTVINYGVQPVWFDDEPANARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZX9</accession>
    <name>B0XZX9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridoxal-phosphate dependent enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_034750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034750"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_1"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="PhylomeDB" id="B0XZX9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000073">
        <property type="entry name" value="Pyridoxal-phosphate dependent enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="57"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP52311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="385" mass="41230" checksum="C927612993A5C38F" modified="2008-04-08" version="1">MPEPSLEAQSLTPDAVRSAYALIQPYVHRTPLLTCQTLNNIASTPQSAESLVGTPFEGQTPANPKFRFFFKCENYQRIGAFKPRGAFHALLRLLAEWGEEEVKRRGVITHSSGNHAQALALAASTLHVPAYIVMPSISTPSKIAGTRSHGAEVIFSGSTSTEREAVVAEIQAKTDAILIPPYDHFDIICGQGTTALEMEEQYRALVADKPHLSAHAGGAEADSGSRHLDAVITPLGGGGLNAGVATFFSGKPTRVFGAEPSFEGADDCRRGLEAGQRVESVKTLTIADGLRTPVGVLNWEVISDRSKVAGVFAVTEDQIKATMRLVLERMKVVVEPSAVVGLAVCLFNEEFRRLVEKEAGPDGWDMGIVFSGGNTTVEAIGKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y048</accession>
    <name>B0Y048_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nonribosomal peptide synthetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_045610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y048"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045610"/>
    <dbReference type="HOGENOM" id="CLU_002220_0_0_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="PhylomeDB" id="B0Y048"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="563"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117401" checksum="DC0761CC03699757" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y070</accession>
    <name>B0Y070_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_034980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y070"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034980"/>
    <dbReference type="HOGENOM" id="CLU_010089_0_0_1"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="PhylomeDB" id="B0Y070"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="497" mass="55372" checksum="0271446270A785E8" modified="2008-04-08" version="1">MLPPIPALADYGVSPDHGFLPPEPPLEALPDPYYAKWEWIASNLQSLLHSGRIRDVVNCLPILQTRYLHSEDEWRRAYVVLTFMLHGYVWGGKTPEEVHMLTLMVDSQRIPPQLTIPLLEVCDHLELPPVATYAAVCLWNYKPIFPDEPAYDLDNLACINTLTGSLDERWFYLVSVGIEARGAPAIPLVLQAISAARTGNSRVVTECLQSIAEILDQIGVLLERMYEHCDPYVFYHRIRPYLAGSKNMADAGLPNGLLYDDGSEEPEYRQYGGGSNAQSSLIQFFDIALGIEHRPTGETRPASTPSEDEKEGVTGAPRHGFIQEMRTYMPGPHRRFLEHVSAVANIREYVEARRSDKALCLAYDACLAMLRAMRDKHIQMVSRYIIIPARDARNRTPETSNARRPSITMNLANVRPGSKKLRGTGGTALIPFLKQARDETGEPAIDAWARRLLSNGPAEPSFAALSKLGEHPDGHLEVVGLSGTWTADDSEGGICHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0I0</accession>
    <name>B0Y0I0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_046270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0I0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046270"/>
    <dbReference type="HOGENOM" id="CLU_1427662_0_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0I0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF153">
        <property type="entry name" value="AFLATOXIN EFFLUX PUMP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="190" mass="21243" checksum="BF1E03301BA3734B" modified="2008-04-08" version="1">MAEARKSRTAIPRASTEEPDHDTITESGDRTRNTASSDVYPTGIQLALLLLAVFVTMFLVALDRLVISTAIPQITDEFGSVTDIGWYGSAYLLTNCAFQLLVGKIYTFSSVKYTCLAAILLFEIGSAKLCRVHLRTGNRWPWVSGDHVRHACYYCLCYPTTQAANHVIYQSKCWTRSYPVADRPVLNEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y165</accession>
    <name>B0Y165_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_048840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y165"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_048840"/>
    <dbReference type="HOGENOM" id="CLU_2621571_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="78" mass="8926" checksum="51546CAE791098AE" modified="2008-04-08" version="1">MVLWRIRTAMCSGNISSCAYLLDRPCAATEVQDAERLVEELRYGMEALERSIAADVVFEGIRMIHKEAERVYETVLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1S6</accession>
    <name>B0Y1S6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_060690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1S6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_060690"/>
    <dbReference type="HOGENOM" id="CLU_2084346_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="117" mass="12190" checksum="5C78CDF2142CFD6A" modified="2008-04-08" version="1">MVGLESSGTKLSPIREDNQSAPACLGKYLSSILAGCGSTTAVEGKQRPQVFLPLIPLPKGGMETRKEKYGGLLVYHSCGSPVNNSCSCSLRGVPPMMVPTGIFNSSTSVNSIQIVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1X5</accession>
    <name>B0Y1X5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_050170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1X5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050170"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1X5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="134"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="605" mass="66810" checksum="3B6AED3A9E011BED" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2E5</accession>
    <name>B0Y2E5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_051170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2E5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051170"/>
    <dbReference type="HOGENOM" id="CLU_005533_1_2_1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2E5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="431" mass="47780" checksum="D5ABC9C4130F5DC1" modified="2008-04-08" version="1">MSTQHGPKSTRTNDLYELAVNISSTVEAFVGRLDAIGAERPNLDNPFPEIIQDEGAQLARLKILRLCERLMALVQGPVQWLMFQNMAFLDAACVGAILDMGIHDIIAPGPEPTSLDQIVEATGASKDILKRIMRVCTQRLIFDEIAPEQFIHNGVSLQFLAPPVQALISHACDDGLRMAAHFTDSLKKTDWKGSDDPENTAFSLAFNTNKGLFDYFYTEDLARGQRFALGMAGSEIMKTLTEDMFPFESLPQGAKVVDVGGGRGHVSVRIAEKVPGLNFVVQDDESMLEAGQAEGVPKAVKDRIEFMPHDFFNEQPVKGADVYLLRFILHDHSDSRCAKILSNIVDAMEPGKSRILIDDAIVPSFLGPESSRFYNLLDLYMLAGLNGKERTLEQWNYLIQMVSPKLVLEKVWKTPNGGPESGTILELRLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2L0</accession>
    <name>B0Y2L0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_062200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_062200"/>
    <dbReference type="HOGENOM" id="CLU_027441_0_0_1"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2L0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44966" checksum="C1174F658A67785E" modified="2008-04-08" version="1">MPRSQAFHAGRQPLQDQRVPLGSAHISGPLAFCNPTRAHFPLSTHSQLHQEPVEKPRIERLWRSRDNRKGRHALTIHQRPPGLAGKTYPRKTIHPIAIANGILRMFTTFPYWDISFWVALVFTVGSGIWVINAFFVWLPLEDPSTEFANEVLTGGGVTAFIGATVFEFGSILLVLEAVNENQTGCFGWAVETAAKEATDAAEEAVVRIKSDRDLCRHHHANRRSFLSPSEARQDSNEQTGIARRRSFAWLPTLNELRSHYRHEIGFWASAVQLVGATIFWIAGFTGLPGIMNHTSPAVTNGVFWVPQIVGGACFILSGLLFAIETQPKWYIPAMHILGWHIGFWNFIGGIGFTLCGALGPATANSGVEYQSTLATFWGSWAFLWGSVIQWYESLEKHPVEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3V6</accession>
    <name>B0Y3V6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_055570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055570"/>
    <dbReference type="HOGENOM" id="CLU_004025_0_0_1"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3V6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="7">
        <location>
            <begin position="135"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="8">
        <location>
            <begin position="390"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP51547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1165" mass="130290" checksum="13CFEA355026AD0D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3Z9</accession>
    <name>B0Y3Z9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_056010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3Z9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056010"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_1"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3Z9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05917">
        <property type="entry name" value="FACL_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="451"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="570" mass="62324" checksum="5C30B7B6CF541F66" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y428</accession>
    <name>B0Y428_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_056300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y428"/>
    <dbReference type="HOGENOM" id="CLU_014950_0_0_1"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="PhylomeDB" id="B0Y428"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="174"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="609" mass="66744" checksum="3BDF7CC18215C4CA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4H9</accession>
    <name>B0Y4H9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_069150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4H9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069150"/>
    <dbReference type="HOGENOM" id="CLU_036235_3_0_1"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4H9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="209"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="404" mass="44644" checksum="20C9C9CC7BEB5A4C" modified="2008-04-08" version="1">MLQPRFALTGLRLPFRCLSSVSSRAYATVIHGQEKPSVEDSSTSTFDPSIAFAPPPTRDDAGVLLRKYKPRTPGIRHLRRPINDHLWKGRPVHKLTFPKRGQGKGGRNNTGRVTVRHRGGGHKRRIRIVDFARTAPGPHLVERIEHDPGRSAHIALVRSQETQKLSYILAAEGMRAGDVVQSYMSGIPEDLWKSMGGTVDPGVLAARTAWRGNCLPLHMIPVGTLIFNVGLRPGKGGQLCRSAGTYATVISKGSDTKTRDNEVETQEDGTEVQKPLSQREKQKQERIAQHVTIRLQSGEVRLIHKDCCATVGVASNPNHQYRQLGKAGRARWLNIRPTVRGVAMNAADHPHGGGRGKSKGNVDPKSPWGLPAKSGYKTRPKWKINKAVVVPRVRNQGKRRRGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4J6</accession>
    <name>B0Y4J6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_069320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4J6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069320"/>
    <dbReference type="HOGENOM" id="CLU_122140_0_1_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4J6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="121" mass="13614" checksum="D0DEEBC67AD1EBC7" modified="2008-04-08" version="1">MSIPNEALQKLLQEIEARAISSQQQIGVTKAQITAKQKNVRLLELTSKEIGSLSKDTKVYEGVGKMFVAVPMDTVDKRLTSERTELKTDIEGLEKKLNYLEMTYKNSRENLEQILKSGGRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4Z4</accession>
    <name>PGLRA_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable endopolygalacturonase A</fullName>
            <ecNumber>3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pectinase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Polygalacturonase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pgaA</name>
        <name type="synonym">pecA</name>
        <name type="ORF">AFUB_070830</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4Z4"/>
    <dbReference type="SMR" id="B0Y4Z4"/>
    <dbReference type="GlyCosmos" id="B0Y4Z4">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP50743">
        <property type="protein sequence ID" value="EDP50743"/>
        <property type="gene ID" value="AFUB_070830"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070830"/>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4Z4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF13">
        <property type="entry name" value="ENDOPOLYGALACTURONASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000393635" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393636" description="Probable endopolygalacturonase A">
        <location>
            <begin position="32"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 2">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 3">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 7">
        <location>
            <begin position="307"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="335"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="368" mass="38110" checksum="C0C05DA680961511" modified="2008-04-08" version="1" precursor="true">MRSVKLFGLAALGSLGAAAPAPSRVSDLTKRSSTCTFTAASQATESASGCSEIVLDNIEVPAGETLDLSDVDDGTTIVFEGTTTFGYKEWSGPLIRFGGKDITIKQNSGAVIDGEGSRWWDGEGTNGGKTKPKFMYAHSLEDSTITGLSIKNTPVQAISVQATNLYLIDITIDNSDGDDNGGHNTDGFDISESTGVYIRGATVKNQDDCIAINSGENIEFSGGTCSGGHGLSIGSVGGRDDNTVKNVTITDSTVTDSANGVRIKTVYDATGSVSQVTYSNIKLSGITDYGIVIEQDYENGSPTGTPTTGVPITDLTIDGVTGTVESDAVEVYILCGDGSCSDWTWEGVDITGGEKSSKCENVPSGASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y550</accession>
    <name>B0Y550_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_071400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y550"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071400"/>
    <dbReference type="HOGENOM" id="CLU_064550_0_0_1"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="PhylomeDB" id="B0Y550"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="199"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="371" mass="40969" checksum="9CABAFE07A07C490" modified="2008-04-08" version="1">MSSPAAAAALASTVTSAAAIGFVPIAVRFQLFDVLADLDKPVSGQDVLSALQERSIERTRQDVPCLLLIQDTLYAMSGLDFVDFVAENLYRANAITKHLAATPSAQHGAVHFTTENLLAGAFLMRKLEAENFQYPFKERETPFQFAYKSMGQEELAKEHTYSIMATEGRMDSFNHFMVGKFMKTNAAPDRLRALGYDLESVLNDAQASTPPTMVDIGGGRGEMILDFKAAFPQLQTSDLIVQEFNHDITDIPGITLAVWNYKDESPQPIKGALIYHLAHILHNLPDLEALRLLKKISEAMAPHSRLLIHGFAKNTTYAKMHAAMIALFGGRERSSTEWHQMAGLAGLRVTFEAYPDFGEGLIEMRKVESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5W0</accession>
    <name>B0Y5W0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INO80 chromatin remodeling complex (Ies1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_064760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5W0"/>
    <dbReference type="HOGENOM" id="CLU_007606_1_1_1"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5W0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="862" mass="95815" checksum="D499A608E40BCFC0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6B6</accession>
    <name>B0Y6B6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_066360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6B6"/>
    <dbReference type="HOGENOM" id="CLU_696631_0_0_1"/>
    <dbReference type="OrthoDB" id="4579491at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44272" checksum="AE3584C6A678EA06" modified="2008-04-08" version="1">MACFHSTTRRYGPNSEDQDNHKANLISQVKSIPQDTSSLRIEESTPSDKEWSILSEQFTNIRDLEMDGGYDEGLNDKEMPLHWPLERLEISSAAGEVIQTPFILQGRVKHLALIFTSGLRFEGPTNAELQRMNREAIDRGDATPRYFTVDEGTPAERQIEVTYIPELVAQWMTDKYSKPNPQVESANRPPAQVTTDTLEIVENDALDAFCRMAVALPHVVDNLQTLTLRSTHGLDFQFARESMFVSVLPHLLNLRTLRLSVGDIFEDRDYLPSLYTKLPPNLSALYFRGPASLCRSEKWEKWIESFASKEYLPELKKLGFVLDLHYEGDKNGKKEVQAPETVLREARAACDRLYAVAKERGITIEAMHDGWADEFEHLRQVDDRWGAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6K1</accession>
    <name>PRTT_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional activator of proteases prtT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Zn(2)-C6 zinc finger-containing protein prtT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">prtT</name>
        <name type="ORF">AFUB_067240</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor required for protein utilization and degradation. Regulates transcription of major secreted proteases including a serine alkaline protease (alk1), a metalloprotease (mep), an aspergillopepsin (pep1), a sedolisin (sed2) and two dipeptidyl-peptidases (dppIV and dppV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the prtT family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6K1"/>
    <dbReference type="EnsemblFungi" id="EDP50386">
        <property type="protein sequence ID" value="EDP50386"/>
        <property type="gene ID" value="AFUB_067240"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030102_0_0_1"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6K1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000011">
        <property type="entry name" value="Transcriptional activator of proteases prtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000407031" description="Transcriptional activator of proteases prtT">
        <location>
            <begin position="1"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="696" mass="78917" checksum="C4C446A1BBD059A9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6S7</accession>
    <name>B0Y6S7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_067990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6S7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_067990"/>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6S7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2140.20:FF:000003">
        <property type="entry name" value="Arylamine N-acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP50462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="329" mass="36706" checksum="D764EBC1F168075A" modified="2008-04-08" version="1">MASPPSTYTPDQIEAYLQRIGYADSASTSGNTRHQHLQQCIEKDPLAALTELQRRHLGAIPWGNSGLHYSQLRAISIHPASVFEKLVVRKLDGYCMENTNLLYVVLRSLGYQVYPTGGRVSRAAAAGSNAVVGYQALVAFADEGRSGHMVLIVTIGGQKYMVDVGFGSNCPTSPLPMKENEVTVCIAPSEMRLIKDSIPELVDRSQKLWIYQVRYNPESEWIPMYSFSEVEFLPQDFGVMNFATSKNPTSWFTQAFVCTKVILSEDGLEPRGIYVMSGKEVKKRLGKETQVVATLANENDRRQALAKYFDMHFQDYDVEGIQGLSSQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y713</accession>
    <name>B0Y713_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_068850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y713"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068850"/>
    <dbReference type="HOGENOM" id="CLU_016696_2_0_1"/>
    <dbReference type="OrthoDB" id="5375558at2759"/>
    <dbReference type="PhylomeDB" id="B0Y713"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="191"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP50548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="773" mass="83782" checksum="D30B3DB30AB3BA5D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7W9</accession>
    <name>B0Y7W9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_075290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7W9"/>
    <dbReference type="HOGENOM" id="CLU_056399_3_0_1"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7W9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28426" checksum="1C84B57A1C41830D" modified="2008-04-08" version="1">MKESSTGNATLEDVEVETFIGFCEYAYTGAYVTPDRILSQEDEGRHLGPSIDEGEEPSFNNIICHTQDEPLLDAAATIADIPDPWDSFIAGKRDKKKKKKNLWDSEPSDGPPPAQITVIYPYERLWEEFRSLKFRSEPAASSSDPDILFHAKLYVLATKYLIIPLRKQCLRSIHRDLCNFSLNRESTSVILNLLDFTYMQTGRGEPGGKSLLQDLVIHYAACEARTLADDENFAILLDSNGEMGSDLAMKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8L4</accession>
    <name>B0Y8L4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_077760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077760"/>
    <dbReference type="HOGENOM" id="CLU_079104_1_1_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="282" mass="31719" checksum="13AC7769AB42A2F3" modified="2008-04-08" version="1">MAITVGVAGITGKFARRVVTHLQKHSDISIRGFCRDPSKVPERISSSHKVTLFKEEAFDVEAVRAFAQGCDVLICCYLGDDKLMIDGQKVLIDACEELGVPREYLATKQKVKGVHILVGGFMEPVLSPFFNILDPQTNTFRYWGEGDEVMEGTTYDNAAEFTVAVARDTTATGIVRFLGGRARICEIAQSYEKAYGVKADLQRLGSLDDPYKLMHEKREQNPSDIYSYMSLFFYYYWVNGQTLVGPETDNAKYPEVKPVSWEGFMSQWPLQQLPTAYFALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8U9</accession>
    <name>B0Y8U9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_078630</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8U9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078630"/>
    <dbReference type="HOGENOM" id="CLU_004174_1_1_1"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8U9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="68"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="14">
        <location>
            <begin position="710"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="840"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="15">
        <location>
            <begin position="991"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP49830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1127" mass="127190" checksum="9AC0FB01AF9463C2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9H9</accession>
    <name>B0Y9H9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_081100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9H9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081100"/>
    <dbReference type="HOGENOM" id="CLU_032690_3_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9H9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="2">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="142"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="299" mass="33305" checksum="F83A00B0D5FCBE5E" modified="2008-04-08" version="1">MENYTIPLEKAVDLTPVSSQLDTFTNAQALWSFVGGYGVYGGSTVAHCLVAAQKTIPSDYVAHSLYCSFVPPANPKQRIEYRVERTRDGKSFLTRTVHATQKAKVISAAIVNFVRAGTYSKSSDTDRAGRLEHGPKRPEGLTVPDEAEMDGKGIDGPFEMRWGEVLNQRSDDLVHTRIRYWMRAKEPMQQTDPQVQLAALSYMSDAYFIGAAVQVYDVPGQTFGTKMAMAASLNHAIYFHHPDAVRADEWMCSERESPWAGNDRALVIQRIWSLEGLLVASCVQEGVLRVQAPFEKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9R7</accession>
    <name>B0Y9R7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_082030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9R7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082030"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9R7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF2">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G05520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP48760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="487" mass="51531" checksum="724EA0B936FC9762" modified="2008-04-08" version="1">MASNSASSAPVPPSVIPLIINGKEEVTPTTFDVISPYTNKPCWTTASATPQDAVRAVEAAEDAFPAWSQTKPTVRRDILLKAADILESRLVQNAEYMRTEMGADVGASQFFIVPLGIRMLREIAGRITSICGSVPVVEEEGQSAIIYKEPMGVILGIVPWNAPYVFGIRSAACALAAGNTTVLKSSELSPCSYWAIARAFADAGLPAGCFNLISCRPQDAPDVVNAMIEHPAVRKINFTGSTAVGRKIARACGQNLKPCLMELGGKNSAIVCEDANIETAVKAVLAGAFLNSGQICMSTDRILIHSSIAPAFMDALKKALGSNLDPSAPPPTLVNVASKARVEGMIDRALESGAHLIHGSLDKTVGKSGVRMAPVLLGGVREDMEVWQEEAFASLAACMVVNSDEEAIRIANSSGYGLSAAVFTEDLRKGLAIAKKIQSGAVHINSMTIHDEPVLPHGGVKNSGWGRFNAAQGLEEFLVTKSVTWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9U8</accession>
    <name>B0Y9U8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb-like DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_082330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9U8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082330"/>
    <dbReference type="HOGENOM" id="CLU_030810_0_0_1"/>
    <dbReference type="OrthoDB" id="2420608at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="427"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="483"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="541" mass="60667" checksum="625737535D914E28" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA12</accession>
    <name>B0YA12_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_082990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082990"/>
    <dbReference type="HOGENOM" id="CLU_045717_0_2_1"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="PhylomeDB" id="B0YA12"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="177"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="302" mass="33355" checksum="CB888575431FB541" modified="2008-04-08" version="1">MAVPRAIRQVFLAIEKAEGAGARVRRSIGTPKLRNFSPFLMLDHFTIGRGAGFPDHPHRGQETITYLLSGGVDHEDFAGNKGTIGPGDLQFMTAGRGIMHAEMPRENPDGSPNVGLQLWVDLPKELKMCEPRYRDLRASEIPVVEVDDGRVTVKVISGQSHGVDSVRDLAYTPVWLLDMTIRPGGRISQPLPEGWNAFAYTLAGTTIFGSNDATRVVKEFHNVVFDQAGGYVEASVPDNAESESRFILVAGQPLDQKVVQYGPFVLTSQEEVYQAMLDYQTASNGFERVRGWESEIGKRMTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA62</accession>
    <name>B0YA62_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_083540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083540"/>
    <dbReference type="HOGENOM" id="CLU_097655_2_1_1"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="141" mass="15881" checksum="FA5B47C781F92AAC" modified="2008-04-08" version="1">MDSLDGTDVKASTDYGDHGSGPDQQKGLDEHRNVPQVRRQLADDLSQCHWTRLQQLYSDIMKQHGNAEEELRARSLRLLESAVLRDESRALKRSRPVQNPVPACADLRRGFREQEKTLCENADVVKAFESALALLNNAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAH6</accession>
    <name>B0YAH6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_084700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084700"/>
    <dbReference type="HOGENOM" id="CLU_852528_0_0_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="PhylomeDB" id="B0YAH6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="326" mass="35297" checksum="EB44688F422A9B4E" modified="2008-04-08" version="1">MFGINIHDKYPDFQTPKNVWTATSERTVKTAQGFILGYTGNETAQIKLTQVGGVQARRSRLVNPVQKLPGIQLQLWLQTVQCTYSPSPPLTARANNPRNSSPTTPNLSLRVSKPRPPPSTSRPTTSSPCSSSAAMRPSSAAPPPSAPSASSPPLNSSPSSYGRDLSPAIGFPWLNATRTILADDSASQDLYVSFTHRELPPTVLTALGLFNNSAYSGANDVNATMPTDAINYGRAWKSSQILPFLTNIAIEKMVCDSYGYDDGVYYRVLVNEGPQPLVGCRDGPGESCSEEAFGRFVQQRGEWYGDFGKACGVDYENSTDVLSIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAN8</accession>
    <name>B0YAN8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_085310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085310"/>
    <dbReference type="HOGENOM" id="CLU_035756_2_0_1"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="PhylomeDB" id="B0YAN8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF10">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE AUR1_IPT1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="177"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="417" mass="47346" checksum="4846799EAC690484" modified="2008-04-08" version="1">MSGRSRQTWANPSSSRTLGSNPSYVMSNLAENLGLAVLTVHLQIVVSIMIGSLIINRRRGFSIFGSRATVDDDGSSTEDYPSKIPTICGITIEVPDSSRWAHHIHSRILQKFPFLVEMFYWVVNYLFYSVTKATSQWLSPAEIGVVQVARDHGIGILNFEHHSIARFFFPIEESDFQSFFLNGHQSIMTFFNRIYSLVHIPGTVLFLGWYYYAAENHNTFAVARRTMTLGNFAAFLIFCFYPCMPPRLLPDSYGFYDTVRQEHAESVWVGGKSVNQFAAMPSLHFTYAFVIGCTFIYHSGLVHRLQGRPVRKSPFTQIFFIIMAVVYPLLVLSVIIATANHYWLDATVATFTVTICFLGNRVLLLLLPVEYCICWVLRLAKPVPTTGDRHLHKWRQSHGDVPLLAEQDSDRFSDSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB03</accession>
    <name>B0YB03_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_080020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080020"/>
    <dbReference type="HOGENOM" id="CLU_1741051_0_0_1"/>
    <dbReference type="OrthoDB" id="4409042at2759"/>
    <dbReference type="PhylomeDB" id="B0YB03"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="172" mass="20268" checksum="309B6B55C810AB6D" modified="2008-04-08" version="1">MAHSRPSSASRKLYLKGKISGRIFSNEGVTRTKFLEYCRTNPRQVFEALLAAQEHFIRSTTSLRGRRDEYYTDIPEEADDTTGDEQYEVDYILDSRMFDGILQYRVKWAGYGYDPEWYNAENFERAPYRVQEFHFRYPWKPGPPKNLDDWLLRAGDDELTIDEFHGCSEPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB79</accession>
    <name>B0YB79_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_091860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_091860"/>
    <dbReference type="HOGENOM" id="CLU_028906_3_0_1"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="PhylomeDB" id="B0YB79"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="318" mass="35893" checksum="7AC123A29F146633" modified="2008-04-08" version="1">MHSGSFNFSLRLHWEDGGEDWLIRFPLPGKSMFLDEKVRREAMLVEFVGSRTEIPVPRVIAYGAAHENPTDLGPFIIMAWIEGRKMSEILRKDTPGEDILNPDIDSRTLGLLYSQMAEILLELWKLDFDCIGCLGQDQQSGQYMVDGPPLTLEVNELMRTCGLGNRTPSGVYHSSTDYIASLLQLQSTHLRDQQNSVYDSEDCREKYACRHLMKAIAFDFISQADNQGPFKLFCEDFGPGNVLVDASLRVTGVIDWEFCYAAPLGFAGSIPSWLLLQRPHRIINELGGAGFLDMFLPKAEIFFFFFELFATEGGSHWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB99</accession>
    <name>B0YB99_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_092060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB99"/>
    <dbReference type="HOGENOM" id="CLU_005767_1_1_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="PhylomeDB" id="B0YB99"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="172"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="675" mass="75557" checksum="01D82E6E3B87E30E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBH4</accession>
    <name>B0YBH4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_092820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092820"/>
    <dbReference type="HOGENOM" id="CLU_015282_1_0_1"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="PhylomeDB" id="B0YBH4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="782" mass="90061" checksum="4CAE1482C35BCFEA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBI7</accession>
    <name>B0YBI7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_086740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP47968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_086740"/>
    <dbReference type="HOGENOM" id="CLU_029797_2_1_1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="PhylomeDB" id="B0YBI7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF294">
        <property type="entry name" value="ACETYLTRANSFERASE MATC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55344" checksum="27B255E833D3F4B1" modified="2008-04-08" version="1">MGFFWKKAALPPPRNPSDTIVPLPAWDDQHRMRACCLHVTYRFDDVLDPEVLRQSLERLLELDGWRSLGGRLRRKDNGKLEYHIPAQYDTDRPGFNYTVVKHSMGINKHPLAASFPQATGQPSLLGDPADLASVCLSADCPTRIEDWLYSDRPQLVIDVVLFGDATLLTVTFMHTLMDAMGLSSFLKAWTAVMNGREDQVPTFQQIGEDPAARFTDRTPAGTYVNSSFLLTGVRLLGFIASYLFELVWHRGQNERVICIPGRCVDEMREQALHELAQQNKEGPAPFLSESDVLLAWWLKALIKALNSSPNRLVSLLNVFDIRSTALQESSSTNTAFITNAALPAITFLRTKEILREPVSFIASHIRHSLVQQRTLSQIEAFFAFDKSASEKYPPVFGEPTSVLVCCSNWHRGRFFEVDFSSAVLAPGIPLHDRVHPLGRPSCVIPTHHSGGLSLRNVGPIIGKDASGNWWLSCTVRTSAWVGIEQELNALGAKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC00</accession>
    <name>B0YC00_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Membrane bound C2 domain protein (Vp115), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_088410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088410"/>
    <dbReference type="HOGENOM" id="CLU_001661_0_0_1"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="PhylomeDB" id="B0YC00"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
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        <property type="entry name" value="C2D_Tricalbin"/>
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    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
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        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
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        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="260"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="460"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="604"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="744"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1116"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="895"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1304"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1493"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="895"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="927"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="940"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1309"/>
            <end position="1319"/>
        </location>
    </feature>
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        <location>
            <begin position="1340"/>
            <end position="1350"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1538" mass="170445" checksum="2A3D25892C1B1327" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC60</accession>
    <name>B0YC60_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP12 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_089030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP48191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="375" mass="41423" checksum="8DDA1550463217BF" modified="2008-04-08" version="1">MGQRGATTSCRTFHAISQKAAVAHPITAHGPPPKPPSPAPEFGRPTEEGKDANDAGKPQSQVSKPSSTLEKRFWKNVDVRKRPGTSPFLLCGLLTSAPPYIKLTFSSCVDGEYQVLLDTRPIRTPTKDILSIPSTKPHLAHAIALEWDVMTSARQALKNHLIPLTSLTARAGDIAQEDARGETTTRDQIVKLAMRYLDTDTLLCWVPERRPYAGEESGENGERPESLREAQMRVAKDIIAFLGTKVWPGVDIVPILDADSILPVSQPQATKDIIKQWVSSLQPHDLAALERGIVASKSLLVAVRLVVEWSENFRHLQRSGQKKFGIEEAAEASSLEVRWQTDMWGEVEDTHDVDKEDLRRQLGSVIVVVSGETRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDA1</accession>
    <name>B0YDA1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_094820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094820"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B0YDA1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000967">
        <property type="entry name" value="ABC multidrug transporter mdr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000240">
        <property type="entry name" value="ABC transporter B family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="705"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="821"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="931"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="968"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="54"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="380"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="713"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1043"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP47635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1285" mass="139547" checksum="13E6F1CCA4E4A2F6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDB0</accession>
    <name>B0YDB0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ToxD-like zinc binding oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_094920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094920"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="PhylomeDB" id="B0YDB0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="21"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP47644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="358" mass="38805" checksum="05923D4454CDC2E9" modified="2008-04-08" version="1">MKAIVTNRFLPKRLLSFALGRSLGNGALIADIPIPQITENEVLVKVCAVALNPIDFKDIDFVSPRNSVAGCDYVGLVTKVGKNSAQRWKVGDRIAGFVHGGQYPDVGSFAEYLKVDGDLAWKVPETMSYAEAATYGVPAATAMLALAYLGIPWADIEKGRDLHTNQSPFLVYSGGSNVGLFAIQLAKRAGLKVVVTASPRSFDLVKRYGADAVYDYRSPTAAAEIAKAYPSITRALDCFSEGGSTAFCASVMKSGKVITLLDRGQPKKPDIEYKSLMVFTVFGRQFSILAPLGPSFPVVPSDRQALQQFYAALPKLCHDVVKPPPITNTQGGFREIFEDLNKLRKGEARGTKLVVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDI2</accession>
    <name>B0YDI2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_095670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095670"/>
    <dbReference type="HOGENOM" id="CLU_2412837_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="92" mass="10223" checksum="A55B9C8CCF264D5D" modified="2008-04-08" version="1">MSSTFAGIWDDSGHDMDCRSRQRTDCTSCLLGIGQLVPLREAEGSIVKHQQDYGFQWREEGDSVSPPCAPDLSTSDRGDYFECVENKALAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE66</accession>
    <name>B0YE66_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular alpha-1,3-glucanase/mutanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_098010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE66"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098010"/>
    <dbReference type="HOGENOM" id="CLU_019141_1_0_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="PhylomeDB" id="B0YE66"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF44">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760857" evidence="1">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="437" mass="48628" checksum="3E61078F9E9A5085" modified="2008-04-08" version="1">MYFGVLLLIVLIAGRGHAAAVFAHFLLSNSANFTSADWAKHIRVAQDAQIDAFALNIAARDAINAQSIPLAFEAAQAAGFKIFFSFDYVARGPWNQDDVTELLLRYKVNEAYYRNNGRPLASTFEGSENAEEWINIKASTDCFFIPDWSSLGAKAAFEKGYGIVDGLFSWAAWPSGPQDMNTQVDLCYIKLLNESEGLVYMMPVSPWFYTNLPGYGKNWLWRGDDLWHDRWQEVLSVRPEFAEIISWNDYGESHYIGPLHEGGYELFRTGKAPFNYAENMPHDGWRTLLPFIIGTYKRGHAEVKQESLVAWYRTTPGSACGTGGTSANTQSHAQIEFSPLEVVADRIFYSALLTEYATPEVIIGSTTQKGTWRNLPASGRGIYHGSAPFNGAKGDVEVTLWREGNRILTLKGKGISGSCYNGVQNWNAWVGSTQSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEZ6</accession>
    <name>B0YEZ6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_101040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101040"/>
    <dbReference type="HOGENOM" id="CLU_012508_1_1_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="PhylomeDB" id="B0YEZ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760970" description="Kelch repeat protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP47109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="83474" checksum="D69AA2E862D7AA04" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJP8</accession>
    <name>H9CJP8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">NADH-ubiquinone oxidoreductase chain 5</fullName>
            <ecNumber evidence="3 17">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_m0510</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="21"/>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the complex I subunit 5 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 17"/>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353067.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJP8"/>
    <dbReference type="GeneID" id="11948065"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010934">
        <property type="entry name" value="NADH_DH_su5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005141">
        <property type="entry name" value="PRK06590.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829:SF2">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06455">
        <property type="entry name" value="NADH5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01434">
        <property type="entry name" value="NADHDHGNASE5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 17 21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <keyword evidence="13 17" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal" evidence="19">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="18">
        <location>
            <begin position="131"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="NADH dehydrogenase subunit 5 C-terminal" evidence="20">
        <location>
            <begin position="503"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AFE02848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="660" mass="73422" checksum="A8C02C426585BF70" modified="2013-02-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMH1</accession>
    <name>B0XMH1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002710"/>
    <dbReference type="HOGENOM" id="CLU_1073555_0_0_1"/>
    <dbReference type="OrthoDB" id="4828117at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="229" mass="23865" checksum="2364FBDBB8C594E4" modified="2008-04-08" version="1">MATLFGQGATYDAIEGRFRRYRKMADDVKADALSRGITELPRGRNGTTSSTSSSLTPRTPRGPRGGITKPSSSTGKSRKSTVSQVLSTPTKRGQGRGGSNNSNNASGMSFMEAIFLDDGLSEEDKKVKSEAAEILTGLVGNSAVVYDLTSASTPTASSASITSMKMEDAAESFSSAFGDAVKQEGRGIGHVTNGDIDVPAIEHDGFDMAGLYFHGHGGYGMDDIYGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMY3</accession>
    <name>B0XMY3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_003720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMY3"/>
    <dbReference type="ESTHER" id="aspfu-q4wk90">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003720"/>
    <dbReference type="HOGENOM" id="CLU_006586_14_1_1"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="PhylomeDB" id="B0XMY3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF6">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="80"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="594" mass="66320" checksum="EEA37862E5B74277" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNC8</accession>
    <name>B0XNC8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_004490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004490"/>
    <dbReference type="HOGENOM" id="CLU_071883_1_0_1"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="266" mass="29914" checksum="539C019C36AE6913" modified="2008-04-08" version="1">MSTSKSSRGSKPSRITVACNSCRSRKQKVSASAPICTQCLQSHRQCDWPEQLKRGPAKGYIEALEHRLHETEQILLRLLAHMTDEQLSIALERNQSPFLRSGKNDAQYWRRYPLRTACDLRKWQQDCFAGTSVAGPPMFSSSRRTDASAQSEVEADEISPGAPESQQTEEQPVPHSEQDPSTRKEGQRSTQTIHGKNMNQHVAWENSYNPSNELRKSSTATGFMYRPSSLELIPFRDTQSLHAGTPPGPSLWSGAPSVAFQRQFLW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNL6</accession>
    <name>AGDC_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber>3.2.1.20</ecNumber>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">agdC</name>
        <name type="ORF">AFUB_015590</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20"/>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNL6"/>
    <dbReference type="SMR" id="B0XNL6"/>
    <dbReference type="GlyCosmos" id="B0XNL6">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP56838">
        <property type="protein sequence ID" value="EDP56838"/>
        <property type="gene ID" value="AFUB_015590"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015590"/>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="PhylomeDB" id="B0XNL6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394914" description="Probable alpha/beta-glucosidase agdC">
        <location>
            <begin position="15"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="881" mass="98888" checksum="15EE1FAA6A1FDAD3" modified="2008-04-08" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNQ2</accession>
    <name>B0XNQ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_005080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005080"/>
    <dbReference type="HOGENOM" id="CLU_2235979_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="105" mass="11693" checksum="C70AA42D683346C5" modified="2008-04-08" version="1">MLWLVPNHRVQSNRAPKGTVPTLTLEESINQRQSTSHWNPAFEMILDFIRSAPVLLSPIKVGMTGQVFLVAYQLSLWMLLLAEMSVLAAVQPPCTTTLIANIPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP09</accession>
    <name>B0XP09_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_005520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_005520"/>
    <dbReference type="HOGENOM" id="CLU_112527_0_0_1"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="PhylomeDB" id="B0XP09"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="161" mass="18102" checksum="5CA61D7EFC5BC6E5" modified="2008-04-08" version="1">MSDYGDHDAEETYDYEPAEEVFDENEPEDFINPEDLEGAEGGADGYGDDHYTPAVNGDRIVVSGDPSAGYLGKVVEQARAKKIPNEERKTTPYMTKYERARVLGTRALQISMNAPVLVDLEGETDPLQIAIKELNQKKIPLIVRRYLPDGTYEDWTCEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPL9</accession>
    <name>B0XPL9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_006850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006850"/>
    <dbReference type="HOGENOM" id="CLU_011300_0_1_1"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="PhylomeDB" id="B0XPL9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760498" description="Neutral ceramidase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="59"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="586"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="764" mass="83447" checksum="67DB43558B571AAA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPM2</accession>
    <name>B0XPM2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_006880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006880"/>
    <dbReference type="HOGENOM" id="CLU_062645_0_1_1"/>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="PhylomeDB" id="B0XPM2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="273" mass="31293" checksum="4D6D648FDB8A128A" modified="2008-04-08" version="1">MDRPGMNRLWDPSKAAWLYPLRGIYYFASHRFLWPLFRARLISIVLLSTFILFVLFLFTYLPQVAFLAIFQGAGAWVNGAFLVLGEGAAIVALLFEAFFVDETLVDIFDAVLVNEGRGELVTACRVLYPQGDDVLKRLGKPTHSAVYSPFSLRQIIEFIVFLPLNFIPVAGTPMFLLLTGYRAGPLHHWRYFQMLDLSKKQRKERIRRRQLQYTTFGTVALLLQLIPGLSMFFLMSTAAGSALWVKDIENKRDALREQRDSITNEYPDDDNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ33</accession>
    <name>B0XQ33_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Patatin-like serine hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_008530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ33"/>
    <dbReference type="HOGENOM" id="CLU_009031_5_0_1"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ33"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="179"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP56147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="589" mass="66259" checksum="BAF5E02AC73A25CE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ48</accession>
    <name>B0XQ48_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_008680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008680"/>
    <dbReference type="HOGENOM" id="CLU_1194664_0_0_1"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542:SF2">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="232" mass="26869" checksum="015039DADA2C8D96" modified="2008-04-08" version="1">MTLIGYFNYLHGRPLCLRLEFFIWAKVLQSARCQRYLEPPFFSVVCFRLSPSCRIGQESSTPETLWSPRLAVSYSPEYIHALGKDQAFDILAQIARIEKKTFPANEAFPFGEDLWKKKPNTRVLYAVSTASGVPRRLVAYAVYVRQKGVALLHKVCVVEAFRRQGIGMQLMNYIRQRLQKEGCQYIQLWVDKAREPARSLYNRSGFEEREEIADYYAPGRTGIRMVLDLKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQW9</accession>
    <name>B0XQW9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_011440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011440"/>
    <dbReference type="HOGENOM" id="CLU_030267_0_0_1"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="PhylomeDB" id="B0XQW9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="379" mass="41681" checksum="3727A6D66CE523CA" modified="2008-04-08" version="1">MEDAGDAKNVILSLDNDDRLSGRARSGSTSNGHKRSTSSSLLSKFSFLRMNTGTHHTTERSHLAGDKHDEEEFNPGLQGGRAMSSALQQRRTRRRRGSLRKTALLGTRFDYRDKKSTRAAIDALRADGHAPPHDQTTNVLVPSIADSVSTQDQPTSLRAAASQTDENNANWGLVHDQRETPSPPQRSRKGPSKEKVHGDEIGTDDEDMIAFPRIKNAKSAIGSAFGNSSTSSTSGAAGLRIPTPPSSSDSYYALPTDASYRAVHRTKSPLATHVVDLKPSQEIVWDYSETEWWGWIILIVTWLVFVVGMGSCFGVWSWAWDVGETPYAPPELEDDPTLPIVGYYPALIILTAVMSWVWVVVAWVGMKYFKHANITGDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQX3</accession>
    <name>B0XQX3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_011480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_011480"/>
    <dbReference type="HOGENOM" id="CLU_131496_9_3_1"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="107" mass="12089" checksum="53469D1A5957499B" modified="2008-04-08" version="1">MSSDAIYNVVKLVPKPGKYDEVVAAFAAFAKHIEAHEHKTQIYFAIRPEGTDELLIVEKYTDAANLKEHASTQEFKNFSRRLAPCLAQSPEMKRSKFLTGFDGRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR45</accession>
    <name>B0XR45_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_012200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012200"/>
    <dbReference type="HOGENOM" id="CLU_034765_3_0_1"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="PhylomeDB" id="B0XR45"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000014">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000043">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="85"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="261"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP56509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="363" mass="40068" checksum="9007F920D6F22E98" modified="2008-04-08" version="1">MKRLQLLRWSSSVRSPRPRTNSRLHQRVCASLRYQSTSSPVTQAEEHQSIEEQSLRSPIPPSNSRQSRYLLPSPPVEAARESAKLAALHARLYLPSRLPLETLARALVDASADPNPDFNNESLATLGHDLLTNYTSEHLICTYPRLPLTVIFAAMYAYVGPKTLSAMAREWGVEMASITSRVVYDNEFGDPVKEVADSAAQAVSETHGAQGVTAEQASATFVRAVMGAIYLHAGRPAAKRFFEQHILSRHLNISELFNFSQPARDLTRLCARENFERPVAKIISETGRKSRHPVFVVGIYSGQDKLGEGAGASLMEARSRAAVAALKGWYLYSPLNVRVPSSMEEEGAAPWKPVYVDLGEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRJ4</accession>
    <name>B0XRJ4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_002680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002680"/>
    <dbReference type="HOGENOM" id="CLU_144945_0_0_1"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="PhylomeDB" id="B0XRJ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="106" mass="11775" checksum="96F85C570A3B2546" modified="2008-04-08" version="1">MSFHLTAEDIRIEDGHRLVARLRNADGDLQDASIDLNTCLGNDNGHFQWDGVDFSHSAQDVHFAIEGGGQVPVLRAQLANQDGEFQDADVNLSERIENINGEFVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSY7</accession>
    <name>B0XSY7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Maintenance of telomere capping protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_028250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MTC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028250"/>
    <dbReference type="HOGENOM" id="CLU_033723_0_0_1"/>
    <dbReference type="OrthoDB" id="5573651at2759"/>
    <dbReference type="PhylomeDB" id="B0XSY7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051008">
        <property type="entry name" value="Telomere_Capping_Maintenance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057530">
        <property type="entry name" value="TIM-barrel_MTC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518:SF2">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518">
        <property type="entry name" value="MAINTENANCE OF TELOMOERE CAPPING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25506">
        <property type="entry name" value="TIM-barrel_MTC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="MTC6 partial TIM-barrel" evidence="11">
        <location>
            <begin position="18"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="597" mass="65106" checksum="AEEF7FAD05B6A907" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT04</accession>
    <name>B0XT04_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_028420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028420"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B0XT04"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF230">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760448" evidence="5">
        <location>
            <begin position="21"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="112"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP54782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="506" mass="55628" checksum="F3043E1451CB6F2B" modified="2008-04-08" version="1">MSYMLSRVFGLIFLFSYTGSIMRLGEDAPFGRQLTHQYQNSPPIHHGCLQLQFFFIKRGNGRFSKMHQSSSADSYEIASIHQDQPTNPSAEPDGDMQTEGRVSWAYPEGGWEAWTCLLGSSLMMFPSFGFQTAVGSVQDYISTNQLAEYSVRDVGWITAILVFLTLFLGVQVGPLFDRYGPRILLVCGSLANITSYLLLAQCRKYWHFVLCLSVLGGISSAVITTVSIAVLSHWFNRRRALASGICMGGSSAGGAIIPLLLRKLFPQLGWTWAIRTIAFMATACYTAGVILVKGRLPTGHRSRAIVDFGAFRSPRLCFLAVAVFSFEFIIFGCAALLPTYVRYAGFPLDVQFYALTLLNSMSFLGRVLPGLAADQLGRFNILLALVVMTLLVMGSVWLPFGSRGQATLYAVVAIFGFGSGGWLSLAPVCAGQLCQTEEYGRFYGTIYSVAAFGVLLTVPVGGELLQSTTPKVLIGFYSAVLMVGLVSVVMARWALLDWRWKWRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT37</accession>
    <name>B0XT37_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_017890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XT37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017890"/>
    <dbReference type="HOGENOM" id="CLU_031475_0_1_1"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="PhylomeDB" id="B0XT37"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760140" evidence="1">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="403" mass="43329" checksum="78DE09CA9A3D76CA" modified="2008-04-08" version="1">MHLVKSIAAGLLLPGCVLASAVPKPAPAPVGQHHPHRITPKVFIVSMFKPEAAVWWNIPEFDLLAHNVTVPGASPVYPDVYCTADYSICQLITGEGEINAAVTVSSIAFSPLFDLTHTYFLIAGIAGINPKVATIGSVTFARYAVQVALQYEIDIRDLGPNYTSPYIPQGAYAPDQYPGSIYGTEVFEVNAELRSLAASFARAAQLADSDTAKAYRAKYVTNNGTYAAGTQTPSVVECDVSTSDVYFSGTILDDVFDNTIRVLTNGTGVYCSTAQEDNATLEALLRAASHNRVDFSRIIIMRTASDFDRPYPGQSAIENLLYADQGAFGPAIQNIYLAGIKVVQGIMDGWNKTFTAGVKPSSYIGDEFGTLGGRPDFGPGRTIARKEANALRKRGVAKRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTI4</accession>
    <name>B0XTI4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_018690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018690"/>
    <dbReference type="HOGENOM" id="CLU_1001073_0_0_1"/>
    <dbReference type="OrthoDB" id="4812032at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="293" mass="32264" checksum="E9A2D99BA081CD9E" modified="2008-04-08" version="1">MSHSPPEPSASSLPTMSTQSLPLRNQATGSCSDEQSNNDATQNTEAAIDPTNLQHLGEKLKILPVPSVNDDLETTAKKMKALARVVSDGNSLALFTGLQVASQHLSDPESIAVSQMTPDERVQYEAWQRSRKNGPMKNPGDQDSEETSSRGEKVPGVGFDWVKNVAPVPNGAQSLKKFTERAAAMDIIWDHQGATPENAAWLTFNQPAILPLIKAVCRVRTAERHRKNNREPSLRGLTDMEAAEVETVRKIVSLAERNRTRELEKIRKLTRSITESVAVIKARVKALEDKRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTM9</accession>
    <name>B0XTM9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_019160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019160"/>
    <dbReference type="HOGENOM" id="CLU_081645_1_0_1"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000185">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP53870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="206" mass="23164" checksum="35A961F3500DB00F" modified="2008-04-08" version="1">MYSQRNDRLYPRFTVNSSRPSSTPMEPSSSPHSAQSFSFADVFPGGNELEIPLGHPFDSVYEFSPPSPYNATTIPDLYALNTSYSVPIPSYSSSYETQFAFTPSFEDSLLAQYSLSTSASSSDSPKLSKPYACEDCGKAFTRSADLKRHQSSVHYPVYQDCPVDDCPRKDRNGFPRRDHLIEHLRSSHHMDLPKRRMTKRVSKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTN6</accession>
    <name>B0XTN6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_029370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029370"/>
    <dbReference type="HOGENOM" id="CLU_005799_0_0_1"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="PhylomeDB" id="B0XTN6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="610"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109773" checksum="B0F8EC14DDF8ACC6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTQ4</accession>
    <name>B0XTQ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_029560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029560"/>
    <dbReference type="HOGENOM" id="CLU_1305229_0_0_1"/>
    <dbReference type="OrthoDB" id="4227073at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="171" mass="19341" checksum="3D329AC655AF1083" modified="2008-04-08" version="1">MPHLHHHRRRHSWPFGSPAAQLRERKIARNSSALGPSTLAELEEHYLAPIVSEDLPEDDAASAGIVRTKTMRSHRCTVSLRQMIRPPLDKARSLFVLPTTTSAGKQVVVSVWVPQAAETQPAYTFADRGRKTTTTDDSDYLTAERNHRRCHSEQPRSWRAPSASLWTLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTR2</accession>
    <name>B0XTR2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_029640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029640"/>
    <dbReference type="HOGENOM" id="CLU_027509_0_0_1"/>
    <dbReference type="OrthoDB" id="5407458at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="651" mass="72346" checksum="07229F07A8B2BDB1" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTV8</accession>
    <name>B0XTV8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_019260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019260"/>
    <dbReference type="HOGENOM" id="CLU_001042_4_1_1"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="PhylomeDB" id="B0XTV8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="768"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="517"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="587"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="675"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="921"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1224"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP53880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1441" mass="161563" checksum="45D856B9AAB9BCE6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUQ0</accession>
    <name>B0XUQ0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_020850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020850"/>
    <dbReference type="HOGENOM" id="CLU_075862_1_0_1"/>
    <dbReference type="OrthoDB" id="10053431at2759"/>
    <dbReference type="PhylomeDB" id="B0XUQ0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF4">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP54035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29890" checksum="7F54845E32A6B777" modified="2008-04-08" version="1">MSTNMSISTQAATCTTTDENISASTTRLNQDKNLAEKLPYWLVNVPPSQWPAECPPFLRDLPAKSISILSTPDAEYKKQDWETVKEIVRSNRIDLFQRVPSELRRYLAFKAHIIANYGSIMRFMAKERLHWGDGDAEDLRPKGRPFEFDEDIRILYNDWPYGVEEGIVHLVVWTKFELEDDPATDDLTPQARKEIDDYVTRTFRSRMPAEQVIWFKNWKSLKSVHAVEHFHVMLYQPDMEFVKEVTQGDVPMTARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUR4</accession>
    <name>B0XUR4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G1/S-specific cyclin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_020990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020990"/>
    <dbReference type="HOGENOM" id="CLU_020695_4_0_1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="PhylomeDB" id="B0XUR4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000065">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="97"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="192"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="416" mass="47021" checksum="A1D2F4A332C1077A" modified="2008-04-08" version="1">MAYHKRPTSSYQPCDSYFVESYDDFPAPRIDPKEHAKLVARERQYAIADELSKAASDEFRDDILAHMLDMDAATLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPATLFLTVNLLDRYCSKRVVYKRHYQLVGCAALLIAAKYGDKKDRVPTIKELKSMCCSLYDDDMFIQMEWHVLQTLGWTVGHPTVDSFLQIAVLDTPHDPEVEHLALYILEISLFHREFVSKASADLARASLALARCILNRPQPRHTEWASQYDSMTLVGLSQQLHQPSQVLSRKYSSSHYSRVAKTLEQFLARQASITSYTPPSPPSDVPSDSKPYYGEIGLATPQKVQSSNLPNGYPTPPITPENEAFANAGNPNFVKEGPETNTCSPSPSPPPMQYVDSHAYNPEAAYAHQPYEQPQMSFTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV07</accession>
    <name>B0XV07_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_021230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021230"/>
    <dbReference type="HOGENOM" id="CLU_2049167_0_0_1"/>
    <dbReference type="OrthoDB" id="10616497at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="120" mass="13099" checksum="FAA711AC9088564E" modified="2008-04-08" version="1">MARPMDTVVLSISPVKGISASLRGALGRLGIQRQVSIIEDSSSLRSEKAQMTERLPDNMKARLHPAPRAATFRRVLPYGEHKQSPDIAPEFSNHHFTSLRSLHNGHGTTSPATQRGHPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV52</accession>
    <name>B0XV52_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_021680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XV52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_021680"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_2_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="PhylomeDB" id="B0XV52"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="396"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="170"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP54118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="806" mass="87268" checksum="114816933B477223" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0XV62</accession>
    <name>B0XV62_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain and ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_021800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002285_0_0_1"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="PhylomeDB" id="B0XV62"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="349"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="403"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="911"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1213"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1318"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1543"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1400"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1450"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1485"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1565"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1585"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1632"/>
            <end position="1642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1655" mass="181391" checksum="646A27E711408C7A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVD4</accession>
    <name>B0XVD4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_032730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVD4"/>
    <dbReference type="HOGENOM" id="CLU_047042_1_2_1"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="PhylomeDB" id="B0XVD4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="188" mass="22071" checksum="6D5DC999C9CF629D" modified="2008-04-08" version="1">MRFLGDIQVQLDEVACLGIAELLKSPSMGEFTREGFVNGWRGVGCDNQQKMIAHAADIRARIPAEPDLFRRVYRYTFPLCRMQGQRNLQFDIAVEQWRLFFTPEHGGIQWNTPTTPWLDWWIEYLEERGKRPVNKDLWEQVEVFLRKTLEDENFGWWSADAAWPGTLDEFVGWVQAKRGKSAEEMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVD6</accession>
    <name>B0XVD6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_032750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_032750"/>
    <dbReference type="HOGENOM" id="CLU_599874_0_0_1"/>
    <dbReference type="OrthoDB" id="4776522at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP55211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="456" mass="51765" checksum="BBE0F2AB21BAFD99" modified="2008-04-08" version="1">MASSPRTPHSHFPLKRQSTQHIFSCYACSYYPTSFFIAYMSRICKAMADNGEGSSRPPIWHSRVPEAQPPRIPFPYINPPPEPRPEDVLPDIFEQRPDIYPGSAWRGWRLRAPFGLKHNLPQYEMNKQCTHGIMVRRFVDDRILCPNCARQPLLGWLLLCVEDLDQPNGPGLSRGISRAMINGHYTFRERTIVRQQRAIVLQHMEQEYGLAAAPFSHIEVIQGIEPGDEVDDNGNDGLPTERMEGIRQENQVESMPCLEQPSRQPRPPCRFWCCYHCMDHIPERASIHLDGFFKNPCTAITLPWELSNKRVSDARVVRNLDNHYKQREHFFGLPTPPYTLSESMSLAIMQPRLMRLCAIASRTDLRSLCDPLKVKEYSSAGLIPGVSDSDSGSAHSFLSGGSRGILIAYAKENAVEPAEVRSTHERESDLDVEVGDDDYGLESLFRSTTLDICDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVT8</accession>
    <name>B0XVT8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_022730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022730"/>
    <dbReference type="HOGENOM" id="CLU_605646_0_0_1"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="460" mass="49844" checksum="51E6490B56C798CE" modified="2008-04-08" version="1">MFSWLANVFDTALRLPETMDLKQVSDMIINAFDNVMGKDSQGLQESRHAPKKEDKAKELKYSQQVVPVNKTSRTSGGLSSPSNTRPLKPCHSSGGSSYNKHTPSKMAELATKYPVADVDDAAGFMAFARALREKQAREAAAAAKIQAEQSTSTQLNGFANGSNDFGGQSPVGANGSDPVSASNDAWPSEAPHSRNAEGFGDFENNTDNNNVSLMPGIEEDAGASKAFASGFRDDATEFIMQDTPVAASDNAVVEEDRENLTTFKSWGTPVTRDKPAAQVRRVIIKGLPSAWSTPAKVLSLIHGGMVESIHITPTGNQAHILFCDHEACKTFFDKYPNGIDIDKEKRKTVFVEMGKEVDVISSQLSFNLSIGSTRVVRAVGVSMNINMGELLKLAGANNRKVEKIVDSCVPGEPRNVVFRFCSIDDAVRFRAAILRDADWEHCNIQHAADPCELASGFHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XW19</accession>
    <name>B0XW19_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_023270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XW19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_023270"/>
    <dbReference type="HOGENOM" id="CLU_010628_1_0_1"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="PhylomeDB" id="B0XW19"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="444"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="762" mass="82936" checksum="FB4E86E1500FE33C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWB1</accession>
    <name>B0XWB1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_024190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024190"/>
    <dbReference type="HOGENOM" id="CLU_130569_0_0_1"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="PhylomeDB" id="B0XWB1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000016">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="120" mass="13618" checksum="A1D65D007B54C736" modified="2008-04-08" version="1">MAPRSQLEIATSSVERLVKEEASYHRELQQQTERIQKLESQEPGEDENREYMLKQEMQRLALEETKKVLPSLKQKIDEAVAKLESLLAEEGKKGPESNVEQITAGKEAIAKAKTAKREIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWL6</accession>
    <name>B0XWL6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_046540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046540"/>
    <dbReference type="HOGENOM" id="CLU_008511_3_1_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="PhylomeDB" id="B0XWL6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="659" mass="73491" checksum="D8AAA47E42934799" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXN5</accession>
    <name>NOP9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Pumilio domain-containing protein nop9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nop9</name>
        <name type="ORF">AFUB_038030</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP9 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXN5"/>
    <dbReference type="SMR" id="B0XXN5"/>
    <dbReference type="EnsemblFungi" id="EDP52637">
        <property type="protein sequence ID" value="EDP52637"/>
        <property type="gene ID" value="AFUB_038030"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038030"/>
    <dbReference type="HOGENOM" id="CLU_008720_1_1_1"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="PhylomeDB" id="B0XXN5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000407797" description="Nucleolar protein 9">
        <location>
            <begin position="1"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 1">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 2">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 3">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 4">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 5">
        <location>
            <begin position="540"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 6">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="699" mass="78077" checksum="243324A9DAA0B5EB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYR3</accession>
    <name>B0XYR3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_041800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041800"/>
    <dbReference type="HOGENOM" id="CLU_507247_0_0_1"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP53009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="520" mass="58705" checksum="326914F18F0CE5A4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYU8</accession>
    <name>B0XYU8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein translocation complex subunit Sss1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_042150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042150"/>
    <dbReference type="HOGENOM" id="CLU_167752_2_0_1"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="PhylomeDB" id="B0XYU8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP53044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="88" mass="9889" checksum="84F42D8D65C4D605" modified="2008-04-08" version="1">MSDTIQELADIPRDFLRDGMLFVRRCTKPDKREFIKISQAVGMGFIIMVSSSSIGYFIKVLGSMRRPFLIVLFTIVHIPVNNILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYX7</accession>
    <name>B0XYX7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory particle subunit (RpnE), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_042440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_042440"/>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="PhylomeDB" id="B0XYX7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="279"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="508" mass="58418" checksum="C54B74B4C81F97ED" modified="2008-04-08" version="1">MSDGGLLKPEKDFSKDADKLIPEAEQLAKSDVEAAIDKLLVLEKQARQASDLATTSRILVTIVTICKDSGNWNLLNDQVLLLSKKHGQLKQATTRMVQTVMKFLDETPSMDVKLSVIDTLRTVTEGKIFVEVERARVTRILSNIKKSQGDVNAAADILCELQVETFGSMTRREKTEFILEQVALCIERGDWSQAAILSRKINKRYFARKPQKSAEEIEKLKKAAEEREKTRAPDEPPMEVDEDVTDLKLRYYEQQIILANHDYKYLAVCKHYREVLDTDSVQSNPEQLRAVSRHLPCLLMWTLTIVTKVLARIVYYIVLSPYDNEQSDLLHRIQQDSRLSLVPVEARLVKLFTVPELMRWPMVAEQFGPHLCNTDVFNAQPSQSVEDQAHKRWQDLRKRVIEHNVRVVAKYYTRIQMGRLTELLDLAEEETEKYISELVTSKTIYAKIDRPARLVNFAKPRDADDVLNEWSSDMKSLLGLLERIDHLITKEEMMARILPSRGEKGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZ93</accession>
    <name>B0XZ93_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial translation release factor (RF-1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_043590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZ93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_043590"/>
    <dbReference type="HOGENOM" id="CLU_036856_5_1_1"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="PhylomeDB" id="B0XZ93"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP53189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="256" mass="28135" checksum="6ABAACB1262079A7" modified="2008-04-08" version="1">MYTAFCSRRGLQSNVIKLDVQDGPSDDRLSEAVVEIDADGAYDLLRTESGVHRVQRVPATETKGRTHTSAVSVMVLPSFPEAGPSMDSALNFDDPNSDYYVDPQEVRTEKMRASGAGGQHVNKTESAIRLTHIPTGIVVSMQDSRSQHANRKKAWQVLRAKLAEARQEAREQELVELRRGVLGGVARMGRGDKIRTYNYGQSRCTDHRSGITVHNLDNVLDGGESLETIMDSVRTWLADQEIAAISAENSINAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZE3</accession>
    <name>B0XZE3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZE3"/>
    <dbReference type="HOGENOM" id="CLU_960069_0_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="290" mass="33179" checksum="799237F8C1A6EC86" modified="2008-04-08" version="1">MATPSGAYLPTRPSPILEPIPHYPSNAIPEERVTLRMGIILSNGCVRVDHQFTFPAMNIANCIIHGEGEMYSVEITHRCTCRRLLHEELVRMLPGFLRENDVYWFRTRNPETNIQHTCLFDGAELEMQLVTSHVPECGFCFARRAFIAERDAFDRQQGQMPRGSASSTSPRDHSLSAGWTFREPSDTERLRVNRHGWEIMFVLHPDAREGAVTISRLRMELCRLLCISDPRRVILTSGPFTWGGDFQEDGKDYYSTYFVHDLIVESRSMKTPRGSALMYVLEADPMGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZG1</accession>
    <name>B0XZG1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BZIP transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_044290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044290"/>
    <dbReference type="HOGENOM" id="CLU_059019_0_0_1"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="145"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="393" mass="43727" checksum="918C349A1E3277A4" modified="2008-04-08" version="1">MTTAALVCEQAPVGKANANDLDRVSLKVTALPLPTVDPRIYPPALLSEDDLHILDSNYLSERTDASVNDDNNKNRPEAVEGQLSELKPASANGIALDTQRSPITSLSSITSTSTSAAAGSETVFPKKPSIPSKRNSKSKSFGKDDPRRERYLERNRRAASKCRRQKKERNQQLENLYRKLSAKHERLLSERDRMRSELLSLKDELLSHAQCEDLPLKLYIAQMVEEAGAAVAPTRPMSTYSVYSENQAQSFMFDHDDALQQQSSIIEMSAVSDTPDWDANLPAQLLYERRNLFPLHLRFPFGDQRSLIQFTETLGPAAFPGKTSMVREAGRRQLVPTAPAHHLARCLSDNLGRRCGRGRGDILVHCEGGWAVRWRIREGQGIDSVDGLVLAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0A8</accession>
    <name>B0Y0A8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_035350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_035350"/>
    <dbReference type="HOGENOM" id="CLU_028723_4_0_1"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0A8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000023">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP52372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="297" mass="33648" checksum="AF8E1E19601BFA27" modified="2008-04-08" version="1">MPPPQPSPEGPLTGKTTSRFRVLAPEIAKIRSSKSPVPPTTEPSASASASANASPSLPQTQTPTPPQSSPRPKRPSLSSLFRQRYATLPTPIRRTFRVLRILAPIVPIGIFFSEHVLQVMWVRGPSMTPFLNKDYETMHTKSDMVLVNMWPFGGAGWPWERKRRLERGMIVTFRSPAHPKHTAIKRIIGLPGDRITTREPCMKASQIVPFNHVWLEGDAEDPKKSLDSNTYGPVSISLITGRVIAVLRPQFRWLNWQDWEKGVVEGDEDHRFGENYRQDVRQRVLKEAVKLERPQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0L4</accession>
    <name>B0Y0L4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_057730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057730"/>
    <dbReference type="HOGENOM" id="CLU_106780_0_0_1"/>
    <dbReference type="OrthoDB" id="4500984at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="257" mass="28928" checksum="C70CDD9AA47D76E4" modified="2008-04-08" version="1">MYTDPITLHPRQDMPYDLRPRALQWDGVMHGNSACALPPSINSAVPFPAAHMAAPQELLLLSPQAPADPGSSQGSPSELGAGGYPDVNTTSGEAKLMNRQSNCRQSQNREAQRRFRERREQERIQLRKRMEDLRAENDALSRMLAEEKNATLKLEVDNEQLTKELETLRRRWQDVLRLMADMVQQEEEVVREGDSPSTWSSSSSSWSSSSRKEVQGLRSSIMMQMLVLLFDEKGESPSRTAMARMGGVVWGSRALID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0L6</accession>
    <name>B0Y0L6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_057750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0L6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057750"/>
    <dbReference type="HOGENOM" id="CLU_1695072_0_0_1"/>
    <dbReference type="OrthoDB" id="4492410at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="155" mass="17231" checksum="CBD07FA8B2676684" modified="2008-04-08" version="1">MFFADKERFIDSIEKDRLLTIARSAFNIVTVFLASPALVTPNLPMFIYTTICNLGLAAMQKMETMSRGDNVWDNCRAVIGSMISWLESSRGQPQSMQAPGNTKDAGDAHMLPQPTPEDAPRPTESAAVAEDWDATVRQQMLQDLTWIGLPVEQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y144</accession>
    <name>B0Y144_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_059560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y144"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059560"/>
    <dbReference type="HOGENOM" id="CLU_106477_4_0_1"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="PhylomeDB" id="B0Y144"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="137" mass="15330" checksum="BD91CBA1699E9DB0" modified="2008-04-08" version="1">MGPPRRKVLATAEETLFPPDELAQGQLIGRVIKATGNNVYLVEYPSKTRALVELPARFRSTIWIKRGSYVVVDTKALEDRDNKLGGEIINIVRDEKAWRKAPFWPKEFVKQPTAVESSDEEGESNVGKMPSSDESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y226</accession>
    <name>B0Y226_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome component Pre6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_050680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y226"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050680"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="PhylomeDB" id="B0Y226"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP51066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="251" mass="27448" checksum="15E9F66EEA09F2B4" modified="2008-04-08" version="1">MEAVKRGTCAVGVKGKDVVVLGCEKRSALKLQDTRITPSKIAQLDNHAVLAFAGLNADARILIDKARLEAQSHRLTVEDPVTIEYITKYIASVQQRYTQSGGVRPFGISTLVVGFDPNDKVPRLYMTEPSGIYSAWKANAIGRSSKTVREFLERNHQDDMDREQTIQLTIKSLLEVVQTGAKNIEVAIMAPGKTIEMLPDDQIEAYVKSIETEKQEEAAKKKTGRTGTTTAAILTRPGGGETGESTRESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2F8</accession>
    <name>B0Y2F8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_051300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051300"/>
    <dbReference type="HOGENOM" id="CLU_528882_0_0_1"/>
    <dbReference type="OrthoDB" id="4493237at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="513" mass="56230" checksum="E048BE98BAF220BB" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2I0</accession>
    <name>B0Y2I0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-glucanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_061880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2I0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061880"/>
    <dbReference type="HOGENOM" id="CLU_016116_1_1_1"/>
    <dbReference type="OrthoDB" id="3426327at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2I0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF39">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760385" evidence="7">
        <location>
            <begin position="19"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="484" mass="54266" checksum="E965607FB1AFA246" modified="2008-04-08" version="1">MRGITSFCAVFLAAAAQARYIVPGGRWRDTNGDLVNAHAGGLLYDHKSGKFWWFGEYKTEGQTEGGGVSVYSSEDLATWEPHGLALKPIEGHPYISPEHIIQRPKVVYSEESNKYLMWWHADNSTYGWLLQGFATSDNITGPYTFVDATAPLGNWSQDFGLFTDYKDGRSYALYSNGDSKYGRDVYLTAYNKNVSALEEVVYRFPKFDLEAPTIIQTEKSYWALMSHKTGYRPNNVVAFRADSLSGPWSQPFMVAPLNTRTFNSQSGFSLRIKGTKKTTYLYIGDQWDSNSLWESRYIWLPMDIDENKKTLDLVWNDVYDLNVYVVNQLNKEILTGPAKPGSGKPSAARHTLPKRPRRTAMRINRKLIQTNVIDTDDMGFGDQRKLPNGPESAATLTVPAGGSPDRIGGSWQLRRISSVVVNGNTSNVETLYQRDTHKSIILSTPLLLTLEKGSHNTITVGGLYNGFDYKGADLDKIVVYPPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y309</accession>
    <name>B0Y309_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_052540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y309"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_052540"/>
    <dbReference type="HOGENOM" id="CLU_062495_1_0_1"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="PhylomeDB" id="B0Y309"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="295" mass="32932" checksum="3BA1AD24408610ED" modified="2008-04-08" version="1">MSFRSPRRLGIGVTPLSVQPTMLQPRLLAPFRALERTFVSSLRSSQAIHHPPRSSLLFQRTPISAPSPISKFLLPLSHVRHASHATQGTANRHSRDPAGKRLGAKRTGGEYVVPGCIIFRQRGTKWFPGENCAMGRDHTIYATEAGYVRYYLDPERHPDRKYIGVCFEKDGKLPTPRNAPTKRRLNRIAVPRIPDGPEVVAQSDLLATVEEGTMISSVVAANATTGPPLRPGYMYREANWQIGRAAEKAGITAKPYKRKNRWLAWRKRQARAERAAQMKSLKSKKKAAKKGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y363</accession>
    <name>B0Y363_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_053080</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y363"/>
    <dbReference type="HOGENOM" id="CLU_001828_3_1_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="PhylomeDB" id="B0Y363"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903135">
        <property type="term" value="F:cupric ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
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    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
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    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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        <property type="entry name" value="ATPase_P-type_domA"/>
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    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
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        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1054"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1092"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1139"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1170"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1207"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="165"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="398"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP51304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1263" mass="141488" checksum="619F77488B8015F5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y376</accession>
    <name>B0Y376_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_053210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y376"/>
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    <dbReference type="HOGENOM" id="CLU_009646_8_1_1"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="PhylomeDB" id="B0Y376"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="222"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="425" mass="46602" checksum="E8682E712CCE9836" modified="2008-04-08" version="1">MQEQLLSTAVNHDLSGNDQQSYEGRIFDSDAYSQASLSSYDGRPINDHDLQRQRSSSFSARFRFAGGPNSIDQFARSWQRAACFPEVLPRRSSFAAVRPDEEWTSGWNEDLASRSSLSARQETDYTRPLLHGDEEEDGGNTGHSKKAFPSTTILSSSLDRSLGTSYGTISSRVSEATRRHALQLHREQLAHRNAAVVPDGEPLLVKQIQRDDGTRDSVIVGQSTVPQTVFNSVNVLIGVGLLSLPLAMKYAGWLLGLFFLLFAAVTTSYTAKILAKCLDVDRNLVTYADVAYISFGHHARIVTSLLFCLELIGACVALVVLFADSLNALIPGLSILQWKIICGFMLMPLNFVPLRLLSVTSVLGILSCTSIVSIIFIDGLVKSDSPGSLRQPARTTMFPDNWATLPLSFGLMMCESTTSFVHVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y388</accession>
    <name>B0Y388_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_053330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y388"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_053330"/>
    <dbReference type="HOGENOM" id="CLU_591800_0_0_1"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="PhylomeDB" id="B0Y388"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361:SF1">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="49903" checksum="518A5EBBD132ED7B" modified="2008-04-08" version="1">MSSISPTPPTPKGSRSNRRNPKKTTTPSNQKMALLTTPPSSPPGNSSPGEIVTDTSINLHNPSKRKNPRSNKKPRDAPKSSPANNNGHRHTSWHPAGSTPQVKDSPHYAGPTFHASPAPSALPIPSFFSKSVPESDPAEEIDGDHLEAGLDLDTTPSKPRPRFQTQSEKSHSTPLDFLFKAAVEARNSQLQRSPEANIGTRSPQTDLKVQRHQMPNCKNGAFAGIFPLEMENSGLQNSQIGPSFATSYKDRMDALRSSSSPSSPTPELHEEERRAKTEALKDLLLNPRPQRPSTASILNHNQAIGHTTRPNLSPNVPHYATPMRTSSGPPATLFKDMPPEQKRSTFESGLQSPFYYSGSVQQPQSSTMKNGMFPPNPMNQISPSPFETYGSSKFPQPLAQQPACYATPHHQSFKSGAIPADTPAPPLDTKKMEDELRRILKLDANPSFPSNSIQSSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3P8</accession>
    <name>B0Y3P8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_054970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3P8"/>
    <dbReference type="HOGENOM" id="CLU_012627_1_0_1"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3P8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="258"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="465" mass="52727" checksum="335728457D9D5594" modified="2008-04-08" version="1">MDYFRVTDVWYERIGGKVGAKVRFEKLSLSTKSWWAAKGSSAPVPYHQRPEIQAEFNRCATCQTAVPRIYNEGWMCLQPTCDSFWKLHGFEPPVDLTFHANFIEARTSPDPEVVPHHDLVPNLLPTLEEDGEGVSYSRIAWKGIVCPRCQKCISRKYWHGWKCTDELIPMSGKGETGCTFEKMLTVQPVSLRSVIDDFGLGPLKRAYHFDGRFAIPDIDDKTLFPYRKLTYRIPGVGSITHFVANRIINSRPDGPNDLFRQLQVADLGLRRYPLQHSVVDSRPFTDAPHEIMRALGRLTWATERAVAGSGDAFLPPNELLMLGYFEDMKIGYHDDGESSLGPTIATLSLGAKSVMSIRMKYKYYNGLSKTKTLLKDDPVLVGCRMEAERRSLKGQLANGEIDRTTYDSLRRKTLQKGKCGEAPIEIKMELNHGDLVVMHGENLQKYYEVNESPKPCLIKETILML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3T3</accession>
    <name>B0Y3T3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_055330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3T3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055330"/>
    <dbReference type="HOGENOM" id="CLU_035426_0_0_1"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3T3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="439" mass="45743" checksum="156E5869BEDD299F" modified="2008-04-08" version="1">MKRENNPIPRFLFASLLSFPAQPSLLLVLSGCPLLALPSPQISRGSSEQINSSKPPPSPPSPPSPSSSPSRKPTPSPLFNMAYYDPQAWQAPPARQASWEHPVQPPSRSDPRLTGALAQRHHSISEFGNPTVPGYYAAQRFQSRPNEVEQMMQAKRRMAAQRERELRNYHQEQQYNRSLLAEMSGNKSDRSLSPAAASEESRRELLARQHRALYGNESPAFFPPNNFGDDNSRPASQAGGTPPSAAGVRGASPRGIDPFGLSQTPVQGNTDTAGGASLQSPSRANSTSSPSSGMNPIFGKLEGSDQPPTSTSSPGRADSPSSRQAAVKPNAGAIGSVGPIGSRPVQQSGPSQISNPALNKRSTTPLPSPLGFGFTSSDGVASGANNDRAASSASNPVASTPATNAGAKESSGGVGLGWGNGSGVWGSKGGLGVQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y426</accession>
    <name>B0Y426_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_056280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y426"/>
    <dbReference type="HOGENOM" id="CLU_018248_0_0_1"/>
    <dbReference type="OrthoDB" id="5418088at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="557"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="656" mass="74871" checksum="DA0484ECA02396E2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y466</accession>
    <name>B0Y466_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_056680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y466"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056680"/>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="PhylomeDB" id="B0Y466"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="308" mass="35211" checksum="58725944390132C2" modified="2008-04-08" version="1">MGKKRVLVTYGVDVDAVAGWLGSYGGEDSTNDISRGVWAGTVGTRRLLKFFDKYGIKATWFIPGHSLESFPEDMAAVRDAGHEIGLHGYSHENPKDMTIEQQRDVLDKTYRMLTEFCGKPPRGSVAPWWETSKEGAQLLLDYGIEYDHSMSHEDCQAYYLRTGDSWTKIDYSKKAEEWMKPLVPGRETGLVEIPANWYIDDLPPMMFIKAASNSHGFVNPRDVEDIWRDHFDYFYREYDTFIFPITIHPDVSGRPPVLLMHERLIEHFKKHDGVEFVTMEQVCDIFKKENPPPAGALMPAEPGAILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4V2</accession>
    <name>B0Y4V2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AP-3 adaptor complex subunit mu, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_070410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4V2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070410"/>
    <dbReference type="HOGENOM" id="CLU_017139_0_0_1"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4V2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="192"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="624" mass="66489" checksum="5B2A6D13FE69E4CA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4V6</accession>
    <name>B0Y4V6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalase</fullName>
            <ecNumber evidence="6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_070450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="6"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070450"/>
    <dbReference type="HOGENOM" id="CLU_006451_1_1_1"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4V6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="775" mass="89816" checksum="481D45B207087E6B" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4W0</accession>
    <name>B0Y4W0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_070490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4W0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_070490"/>
    <dbReference type="HOGENOM" id="CLU_056435_7_0_1"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4W0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000438">
        <property type="entry name" value="Probable thiol methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF11">
        <property type="entry name" value="THIOL METHYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="282" mass="32077" checksum="47CADF1D42FF97B0" modified="2008-04-08" version="1">MSNDPRLVSSIPEFIARYKENYVEGWAELWDKSEGKPLPFDRGFPNPALEDTLIEKRDIIGDPIGRDAQGNTYRKKALVPGCGRGVDVLLLASFGYDAYGLEYSATAVKVCKEEQAKNGDKYPVRDAEIGQGKITYVQGDFFKDTWWEKLQLPRNSFDLIYDYTFFCALDPSMRPQWALRHTQLLADSPRGHLICLEFPRHKDTSLQGPPWASTSEAYMAHLNHPGEEIPYDANRQCSIDPSKAPSPQGLERVAYWQPARTHEVGIVEGEVQDRVSIWRRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5A0</accession>
    <name>B0Y5A0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_071890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5A0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_071890"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5A0"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000045">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="6"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="253"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="350" mass="36687" checksum="479BB8AC591166F3" modified="2008-04-08" version="1">MSSNTAHICVVGSLNIDFAVSTSRCPGPGETLTANSLSVTAGGKGANQAVACGRASHTSSDASKVTVSMIGAVGADDVYYATLIRPTLEDSGVDTKYVEEKTDSRTGSATIIVEDSAHGENRILVVPGANHAGMDDVSKILATIQSYPQAPALIVLQGEIPRHTTLDLMRHFNQPGNQTHMLFNPAPVFADGVPVDALSNTSVLVMNETEAVQMQASISPESAISTQTTDELKPEDLASQFHALANVRIVLITLGAKGVFFSTRTGRKGFVAGVRVQKVVDTTAAGDTFVGYFAAAFAEFIATSAPLEEFDKTIEQAVRRANCAAALCVQRPGAMQSIPTASEVDGLDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5D6</accession>
    <name>B0Y5D6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_063030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP49971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5D6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063030"/>
    <dbReference type="HOGENOM" id="CLU_017096_0_0_1"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5D6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="321" mass="34572" checksum="C329C3D942433C84" modified="2008-04-08" version="1">MISSTFTPSLSRRDTNKSSVGHEGVGGGGPPPLTSGGGSFGPQSAGAIYQHIHDMATKRISTLDYLRKAHEGRIYWFNTVHFSRADISRIPYFDPRKLSRRAINYLLLGISLPPILDVNSSPSEYLRALNALLIEFEAFQQVHPPDGSSSSTLARARIPQMFKRAAHAGTKGRRASSATEIGLPMQSSDPSDLKSMTGNITSSTTAAAAVVSFPTSEASELLPGEEYSYLLTPSLPFEPDYFETFATLCDVLIDCYTRLTALVSTPSVCTVALGEMFSKADAKLRKIMVTGVVREFEDASRTSAKNEIAGVSRVVLGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5H6</accession>
    <name>B0Y5H6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_063430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5H6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063430"/>
    <dbReference type="HOGENOM" id="CLU_106853_0_0_1"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5H6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="2">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="147" mass="15813" checksum="22FC7AF30A74DE6A" modified="2008-04-08" version="1">MASLKESLAGPGFVILNAIRVFNIIVFLDIIAASIVMIVKISLLSSFFFFQAVSHVMAAGISIFLILSELPFFRGYFDRNWPLLGQDSGFVTLAVAMLILGMGVLGDLNTPATSQESLGLAFWRIVVSAGILAMVMSVVNLVSVSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5L5</accession>
    <name>B0Y5L5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="9">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_063810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="9"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5L5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_063810"/>
    <dbReference type="HOGENOM" id="CLU_015869_2_0_1"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5L5"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP50050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="421" mass="45840" checksum="895D5DA4BA9DA389" modified="2008-04-08" version="1">MIELGLGRISRLLQQTPLSWKAIHIAGTNGKGSISAYLSHMLTAGGVRCGRFTSPHLIDRWDCITIGESVVQESLFRQIEERVRLRDQSLGIGASEFELLTATAFEIFNHEHVEVGVVEVGMGGRLDATNVLSDVLVSVIAKIGLDHQAFLGDTLELITREKAGIMKPGVPCVVDGTNAPEVIRTLENRVNELKIDAVYAHPDTICSQSPCLGRIFRELDLQRHQRANMSCAVSALRLALAKVRPGLEVDMLLPSLKNVEWPGRLQKISLSPLTARTEPVLLDGAHNSQSAEVLGEYVNKNLRPQGKITWVIAASRGKDVTALFHSIIKSGDKVAITAFGPVDGMPWVKAADTEDLALCIQSIPGVQDVRTFDGDVLAAINWACTEAGDCPLVIAGSLYLVSDVHRLLREARKSAEIYRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5S4</accession>
    <name>B0Y5S4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_064410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5S4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064410"/>
    <dbReference type="HOGENOM" id="CLU_099515_0_0_1"/>
    <dbReference type="OrthoDB" id="4868994at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5S4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="182" mass="19943" checksum="67456B90B696864B" modified="2008-04-08" version="1">MGLAVESGVEKLGWTPAPSVIDSFFSYEENSLWRRRKLKAAEGLDSVGSSGTMAGEDTTEKAKQSLMQRAKSWGENPFPPTLLASLITAQHMRPFQFLPMLFPPVLLFTSYANIQGFKTDSAGISAAWSGLYLLLAGRRRQPLMKKWGARGIVRGTTMGLCLLNMVGGGLAYTLGKREDHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5T8</accession>
    <name>B0Y5T8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_064550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5T8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064550"/>
    <dbReference type="HOGENOM" id="CLU_2922195_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP50123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="61" mass="6783" checksum="1EB26AE7812C348B" modified="2008-04-08" version="1">MDDEAQARVVAFNGEQSYIASSVQRSLCDVTASTCIERSNHDHSATDIIFHRPTSPYILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Y1</accession>
    <name>B0Y5Y1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_064980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064980"/>
    <dbReference type="HOGENOM" id="CLU_069253_1_4_1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Y1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03021">
        <property type="entry name" value="DsbA_GSTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044088">
        <property type="entry name" value="GSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="220" mass="24307" checksum="44D1E9F17F034126" modified="2008-04-08" version="1">MAAPKITLYFDVVSPFAHIAFHVLKHSPTFAKCDITYVPIFLGGLLKACGSTPPIQIKNKAQWINQERRRWARYFSVPIVEKTPPGFPALTVAPQRALCAISKKAPERFVPAVEALFQSYWVEGNGQIGQPEGFGPVLEKVLGKDSTEQILKAMSQDEAKSLLLANTDRAFKSGAFGLPWFECTNPKGETEGFWGIDHLGQVAEFLGLDRSLDKGFRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Y5</accession>
    <name>B0Y5Y5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_065020</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Y5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065020"/>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Y5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="523"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP50170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118583" checksum="6F1C98BC0D40BDC4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Z1</accession>
    <name>B0Y5Z1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_065080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Z1"/>
    <dbReference type="HOGENOM" id="CLU_021763_1_0_1"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Z1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000006">
        <property type="entry name" value="DNA polymerase delta subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="12">
        <location>
            <begin position="70"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="11">
        <location>
            <begin position="238"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP50176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="554" mass="61288" checksum="9ED00DADCADFBA94" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y628</accession>
    <name>B0Y628_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_065450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y628"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065450"/>
    <dbReference type="HOGENOM" id="CLU_029631_2_0_1"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="PhylomeDB" id="B0Y628"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP50213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="511" mass="55711" checksum="BF633D9C61189B51" modified="2008-04-08" version="1">MIYLRSSLLRSGLAQDSARLCSQCFSRLSPSRRPVAVRSFSSSRLRAGIADHESTPSTVQKTYFSANRTADGLLASLSAVNSSPRSIADNALSQGAASSESITSQSTSQELPHRRRKRLKEEAAKNNAAETELPPDASSQLSTLSSALPATSLRRKLAAFLALTKPRLSFLIVLTTTSAYGMYPISSLLTLDPSMTPLPTLSTSTLTFLYLTTGTFLSSCSANTLNMLLEPKYDALMSRTRNRPLVRGLLSRRAAVLFAIATAAAGLGLLYIGTNPTTTALSASNICLYAFVYTPLKRISVINTWVGAVVGGIPPLMGWTAAAGQTATTGHDSWRDMLFSKDSIGGWLLGGILFAWQFPHFNALSYMIREEYKAAGYRMLAWTNPAANARVALRYSLLMFPFSVGLWWVGVVGNGFLVGSTVANGWLVKEAYKFWRHQGANGSARRLFWASIWQLPILLVGGLVTKKGLWDGVWNNVFGQPVEDEDDYLWEDEDEVAEAERRMIPAKTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y677</accession>
    <name>B0Y677_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RING finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_065940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y677"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_065940"/>
    <dbReference type="HOGENOM" id="CLU_1194654_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B0Y677"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000648">
        <property type="entry name" value="RING finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP50262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="232" mass="25928" checksum="A283AE09FFF188BE" modified="2008-04-08" version="1">MRGWLLATRVLTCLNSLGVPKVGRSKVESSSATPLGYIAPPIVVFLFLLVWAVITIRYRSHRREAETRRLYFLGRTILADVDINRQFPLAKLSIWRALHRGKQALGAESDVPDPILCSICMEQLRDDEDVRPLPCEHIFHPECVDPWLTRYHTSCPLCRVSLVEDDGKLDLEDGRPPRLLTLPVPPQPALIGFAGRFGWSVFLSLRDFMCPVIAVCLAADGSIRGIATGVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6D9</accession>
    <name>B0Y6D9_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tryprostatin B 6-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Fumitremorgin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AFUB_066590</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tryprostatin B + reduced [NADPH--hemoprotein reductase] + O2 = 6-hydroxytryprostatin B + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35955"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:72760"/>
            <dbReference type="ChEBI" id="CHEBI:72762"/>
            <dbReference type="EC" id="1.14.14.118"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.118" evidence="14"/>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066590"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6D9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0349">Heme</keyword>
    <keyword evidence="9 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP50324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="526" mass="59564" checksum="FDCEF46771D2E5A6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6M8</accession>
    <name>B0Y6M8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_067510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6M8"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6M8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000181">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="57"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="437" mass="47893" checksum="3F1FC74EBC6AAE2B" modified="2008-04-08" version="1">MLSTLRVASRQAASREASMRTVVIGARHASAWSNVPQGPPDAILGITEAFKADTFKEKINLGVGAYRDDKGKPYVLPSVRAAEDKVVASRLDKEYAGITGIPSFTKAAAELAYGSDSAVIKEDRLVITQTISGTGALRIGGAFLQRFYPHAKKIYLPTPSWANHAAVFKDSGLDVASYRYYNKDTIGLDFEGLIADIKAAPNNSIILLHACAHNPTGVDPTQDQWRQISDVMKEKGHFAFFDMAYQGFASGNADRDAFAPRHFVKEGHNIALCQSFAKNMGLTMLNHQGLYGERVGAFSLVCESAEEKKRVDSQIKILIRPFYSNPPVHGARIASTIMNDPELNQQWLGEVKGMADRIIEMRALLKKNLEDLGSKHDWSHITSQIGMFAYTGLKPEQMEVLAKEHSVYATKDGRISVAGITSGNVKRLAEAIYKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6S1</accession>
    <name>B0Y6S1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_067940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6S1"/>
    <dbReference type="HOGENOM" id="CLU_034766_1_0_1"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6S1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000004">
        <property type="entry name" value="Spore development regulator vosA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="37"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="445" mass="48982" checksum="F2218EAFAC9651D1" modified="2008-04-08" version="1">MPLFPANPRGLSDLPSHRNGLLDSYSAVQGLQLTMLSNTSSDFELIIRQQPNRARVAGGKEKERKPVDPPPIVQLRVREEGSYLAHLYDANEDQPVPVPPATALAGTLVSSLHRLKDVDNNDGGFFVFGDLSVKIEGEFRLKFTLFEMRKDVVTYLKSIISDRFTVSPPKTFPGMQESTFLSRSFADQGVKLRIRKEPRTLSLKRPPRPEEYPQQPLPRSPDRSSMQMSGNAFTGYPAAGRDYAYYGTPVKRQRTSVDYGNRGIYDAEGRMRQVDAYPQTTAMYPNQPGTYQTPMMQGYPAGHTGVPDYAMPYGIPPSAQVAQMQDPAAHARSSQQATMQSLGMMNQPGTPTADSTAAMMPQGYPQPRTQQYQTSSTILPPLQRNRNFPQGTNGASARGYFDQASQGATPILPSQPMGSTEGDRYGAAPGQTTFEHPGSHNGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7V7</accession>
    <name>B0Y7V7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_075170</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7V7"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_1_1"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7V7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="14">
        <location>
            <begin position="78"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="510" mass="56600" checksum="79AD61208CF54E9F" modified="2008-04-08" version="1">MSTCKAVAQRWPRYLHRHIPFVAPSPSIRPALRRCRMSKQPSLLRSYASISAADLKFGQPLHETHPHLLNPGELTPGITALEYAQRRSRLANKLPKNAIAVLAASEVTYRATGIFNNYRQDSNFFYLTGFNEPNALAIIANDGSGDNHIFHLYVREKDPRAELWEGARSGTQAAIDVFNADEVERLALGTGDIGRIGDILPTILSGATEIYTDIPAFNPGRSSLHHFLYGPTNASEKLKKMVDYHKVKPLRNILNEMRVFKSEDEVVQLRRVGQASGRAFTETMRQTFTKEKDLNSFLEYNFKVNGCDGSAFVPVVAGGSNALSIHYTRNDDVLRNGDMVLVDGGGEWGTYISDITRTWPVNGKFSDPQRDLYNAVLNVHRSCVSLCRESAGLSLDKLHSIAENGLKDQLQQLGFDVSGSAMGILFPHHLGHYIGLDVHDCSGYSRSQNLKAGQCITIEPGIYVPDSERWPEQFRGIGIRIEDSVCVGDDNPIVLTTEAVKEVSSNSIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y823</accession>
    <name>B0Y823_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_075840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y823"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075840"/>
    <dbReference type="HOGENOM" id="CLU_1777033_0_0_1"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16631" checksum="62D1FC179AED4CB2" modified="2008-04-08" version="1">MYSTILNALGGSGGWIMTLNCNDEYYKNIGKSVDANGNAIIKYEDTREDGIKGETAEMPAEFGMCYEKTELNGWSFFNQLTNKQEMAISPAALDRYRTKNKLSDIENTEAALKGKSLTGLKLRAAATTILHEMTHFYSLFGAGKTDYPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8B1</accession>
    <name>B0Y8B1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XAP5 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_076720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8B1"/>
    <dbReference type="HOGENOM" id="CLU_037985_0_0_1"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8B1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="365" mass="40606" checksum="8AAA314820E6A5D8" modified="2008-04-08" version="1">MPPSEQQSGNSTPRFTSQTTSAEDLLKSQTVGLVHLSDFRKRRAEVLEQKEREAHDKSLGRFTSGNSRSATPSTGDVTDSEGPPKKKKKKQLMKSKLSFGDDEENDTGDEPVATPRETSVPRSASRTPADDSSAPSSRRITPNPNAPPPPKALTKAALKAEAEARDALRREFLAMQEAVKNTEILIPFIFYDGTNIPAGAVKVRKGDPVWLFLDRCRKVGAELGVAGASGAAKGRKDNRREWARISVDDLMLVRGEIIVPHHYEFYYFIANQVPSFSSAGGLLFDYSNKPPPAASSDNPLSRPDNDHLEGADKDATLTKVVDRRWYERNKHIFPASLWREYEPGPEFEQKMRSTRRDAEGNTFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8R1</accession>
    <name>B0Y8R1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_078240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8R1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078240"/>
    <dbReference type="HOGENOM" id="CLU_018249_1_1_1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8R1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760522" description="Arylsulfotransferase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP49792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71517" checksum="1DE0622D9DE1C3EE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9C5</accession>
    <name>B0Y9C5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9C5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080540"/>
    <dbReference type="HOGENOM" id="CLU_124525_1_0_1"/>
    <dbReference type="OrthoDB" id="5426707at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="108" mass="12216" checksum="B53C3ABEE95638D6" modified="2008-04-08" version="1">MFRRHRPTTTTTRTSKPSLLTRLRGPNARTRTVKTKTPTTRHNGAYGRTRATAPVHHHRRKVTLGDKVSGAMLRLKGALTHRPAVKAAGTRRMHGTDGRGTRHRRAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9F0</accession>
    <name>B0Y9F0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_080800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9F0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080800"/>
    <dbReference type="HOGENOM" id="CLU_431448_0_0_1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9F0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="687" mass="74890" checksum="E0C5849A41B672E5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9W3</accession>
    <name>B0Y9W3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Beta-hexosaminidase</fullName>
            <ecNumber evidence="3 9">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_082480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3 9"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9W3"/>
    <dbReference type="HOGENOM" id="CLU_007082_0_2_1"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9W3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758784" description="Beta-hexosaminidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="13">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="12">
        <location>
            <begin position="182"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP48806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="600" mass="67424" checksum="D50E0686BB81F801" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YA90</accession>
    <name>B0YA90_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_083820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YA90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_083820"/>
    <dbReference type="HOGENOM" id="CLU_097262_2_2_1"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="PhylomeDB" id="B0YA90"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000069">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="51"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="151" mass="16054" checksum="CEC32F03708CE8C6" modified="2008-04-08" version="1">METPSGLTIQELETLSSKAIAAKANAYCPYSKFRVGACVLTKAGEYIAGANIENVAYPVGTCAERVAFGTAIAAGHQDFKAVAVATDITPGASPCGMCRQFMREFTTPSFPVFMYDGQGNYAVRTMGEVSNFFIAHSFFHIAACLRSIAGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAA4</accession>
    <name>PGXB_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable exopolygalacturonase B</fullName>
            <ecNumber>3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Galacturan 1,4-alpha-galacturonidase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Poly(1,4-alpha-D-galacturonide)galacturonohydrolase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pgxB</name>
        <name type="ORF">AFUB_083960</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP48947" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.2.1.67"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48947.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAA4"/>
    <dbReference type="SMR" id="B0YAA4"/>
    <dbReference type="GlyCosmos" id="B0YAA4">
        <property type="glycosylation" value="9 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="PhylomeDB" id="B0YAA4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000040">
        <property type="entry name" value="Probable exopolygalacturonase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF6">
        <property type="entry name" value="EXOPOLYGALACTURONASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393675" description="Probable exopolygalacturonase B">
        <location>
            <begin position="17"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 3">
        <location>
            <begin position="362"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="392"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="453" mass="50030" checksum="EE6E8C5A46BC5B71" modified="2010-04-20" version="2" precursor="true">MKFFALAALFASTVNSIAVDGLIPGARVIPANDVVALKKAGAYHQKHHHRRTVIIRSSSSDEDDVSADFLWGIKRANHGGRLLLQNGKKYVIGKKLDLTFLKDIEVQLDGELKFTNDVPYWQANNFYYDFQKSISFWRWGGEDIKIFGSGVLNGNGQRWYNEFAGQEILDPNNKYYRPILFVTENATRVSVEGITQLNSPCWTNFFVRTKDISFDNVFIHAYSTNASALPKNTDGFDTLNVDGLTVTNTRVDIGDDCLSPKPNTTNVFVKNLWCNGTHGASMGSIGQYPGVLDIIENVWIENVTLLNGENGARLKAWAGPDVGYGRINNVTYKNIHVENTDNPIVLDQCYFNINATQCAAYPSRVNFTNIVFEDIYGTSSGKRGKVVADLTCSPNAVCSGIRLKNIHLTSPAGSPPVIVCDGIQGDIGVECQSSSNSTTKRSVDLARSLKYRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-11-25" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAK0</accession>
    <name>KATG_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Catalase-peroxidase</fullName>
            <shortName evidence="1">CP</shortName>
            <ecNumber evidence="1">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">katG</name>
        <name type="ORF">AFUB_084930</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="1">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="1"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAK0"/>
    <dbReference type="SMR" id="B0YAK0"/>
    <dbReference type="Allergome" id="8994">
        <property type="allergen name" value="Asp f CP"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP49043">
        <property type="protein sequence ID" value="EDP49043"/>
        <property type="gene ID" value="AFUB_084930"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084930"/>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_1"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="PhylomeDB" id="B0YAK0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0376">Hydrogen peroxide</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000354099" description="Catalase-peroxidase">
        <location>
            <begin position="1"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-268)" evidence="1">
        <location>
            <begin position="96"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)" evidence="1">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="759" mass="83762" checksum="4519FF268CE43B8F" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAK2</accession>
    <name>B0YAK2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NRPS-like enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_084950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084950"/>
    <dbReference type="HOGENOM" id="CLU_000022_2_17_1"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="PhylomeDB" id="B0YAK2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="523"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111721" checksum="D0A1F2CEA337269A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAN0</accession>
    <name>B0YAN0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NB-ARC and TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_085230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085230"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_7_1"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="1">
        <location>
            <begin position="427"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="867" mass="98435" checksum="ED58C0A7995F4D15" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0YB40</accession>
    <name>B0YB40_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_091470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YB40"/>
    <dbReference type="HOGENOM" id="CLU_043547_2_0_1"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28003" checksum="06D38C6B326BBD5B" modified="2008-04-08" version="1">MLMQNRDTAKSSDTPEQLMGNLIYFRAQSLPHLLALLLHPPQGFPPENTKLLVVDSVSGPFPSYFLSPSELKSRLAQAKITDKSQIHWLMNRRWNVTSELANQLMKLAASRRMAVLIINQTHTKIKGLPRATLSPLLAGGAWENTVHTRIVLYRDLPAVDEEESEMASRSLRYAEVLKRDGKALTDSLRGTDTTQPSRTVPQQPVEETFPAGGRKRKVDEIADSQDEGDSDEDFGWVDGDDAGLVEGPADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBQ8</accession>
    <name>B0YBQ8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_087500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087500"/>
    <dbReference type="HOGENOM" id="CLU_019101_2_0_1"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="PhylomeDB" id="B0YBQ8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF30">
        <property type="entry name" value="FAMILY DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP48039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="374" mass="42195" checksum="1F8093F697F50A61" modified="2008-04-08" version="1">MILTSEEWVWLAVVLLITTLRYVSRILQVGVPRNLQMEDIIMGVVVIFYILLTVFLVEVDKHGTNGIPPSAFDTLDKAAIPDRIKGSKMVVAVEQFWLAVVWGCKCCLLLLYSTMTSGLRQHRIVKVIGGICAFSFLLIEILFFAVWCRPFSAYWSVPPKSAQCSVYTNHVIITLVFNVATDVLIMAIPLPLLIRAKLSLSKKLTLCAVFSLGAFVILCSILSKYYSISQPYGIKWLQWYVREAATAVIVSNIPQTWTLFRRLFNWKSFLQHSSYNRSQNKYTSRLDSSTVHLSRLRGNKSGVRSTVDRSESGEHIAREQPLEIWAHRQFHVTNEVHEERRSGSLSQSSGSLEFDTATTVAEDGPVKTTVTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBU0</accession>
    <name>B0YBU0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_087810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087810"/>
    <dbReference type="HOGENOM" id="CLU_025145_3_1_1"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="PhylomeDB" id="B0YBU0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP48071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="480" mass="53308" checksum="416AF844E0374691" modified="2008-04-08" version="1">MVADTTYYDALGVPPTATELEIKKAYRKLAIVTHPDKNPGDETAHARFQAIGEAYQVLSNEELRKRYDKYGKEESVPGGGFEDPAEFFSMIFGGSAFVDLIGEISLMKDLTATMDITMQEMEEEELAEAAEEKLHIHDEGVKAAAATGEASHAAGTAAPGPGPVPAAAAAAEPSEKPASTSGSSTPRRYLGQQAIMDKSEEEARMEAAGLSQEEKELRKKEKKKGLSREQQERLAAYELERKKAREERVNTLATKLVDKLSVWTETDKGPDVTRAFEEKIRLEVENLKMESFGLEILHAIGATYTSKATSFIKSQKFLGISGFFSRLKDKGTLAKETWTTISTAIDAQMTMEEMAKLEEKGGEDWTDEKKAEYEKKVTGKILAAAWRGSKFEIQSVLRDVCDQVLGDKRVKLEKRLERAHALVIAGNIYSKAERDPEEEGDYMAFEQLMAEAMSKKGKDEKKKKKEKSKNEHHHHEATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC16</accession>
    <name>B0YC16_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucine Rich Repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_088570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC16"/>
    <dbReference type="HOGENOM" id="CLU_024395_0_0_1"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001689">
        <property type="entry name" value="Leucine Rich Repeat domain protein (AFU_orthologue AFUA_7G02000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP48147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="384" mass="42793" checksum="E393066D1E739AD7" modified="2008-04-08" version="1">MRIDLSDARGKIHWPSVRAYIRRSKAMLTHAIVKNISTPSTQRVLEFFSRCPNLEHLEIWAQSKPDVLYDLYKSSKGLKTLIISGHTALPQETIGKFLQTLPLLERLEVHEAKPSNLARVQWPEKLPSLKSITFGAMVGASVPDVQAPALHLPQRLSTCLPNLEELRLSWNPQIFTPYRLNFDVNELSRLRRLDLSGMYVGAEFGLPSSLEYLRIRGGTGLVGGSLVQREFPFVYKEPFELPNLHTLILTDVPWATGYTVRHFCTIAQAPLKVLHLDSCFRITGAQISELVRMDSLSDLQELNISHIAGTDDKSAAVIIGALPSLKVVHLSYTRISGCTIKAFADARSSDDSVAKVDRIYAKFCDEVSSDAVAYGRSRGVEIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0YCV3</accession>
    <name>B0YCV3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome c mitochondrial import factor (Cyc2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_093310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YCV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_093310"/>
    <dbReference type="HOGENOM" id="CLU_003827_6_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="PhylomeDB" id="B0YCV3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="78"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP47487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="381" mass="42132" checksum="6150E20A022CCFBC" modified="2008-04-08" version="1">MKSRLPRSGGLLFNPPSTLSKRAASRRYTASSSPTTSAPSPPKRRLWLRLTIVTATAAGIGAYVRSQQGSESTTLNPVTFTKYRLVAREPVSSNGSIFTLKPPKPDDNREVYEDAWKTGVWSVMFKQPQLQIGRDYTPLPPISLNDQDEQEGCLRFFIRKDPFGEVSRYLHSLDVGSAIEVRGPRIECEIPSDTRQILFIAGGTGIAPALQAGHTLLRRTDADHKPRLHILWANRRRDDCLGGCNDSSAIDEVQQRSWFTGLFRSRPSSPPPAGPTQDPAATSLMVRELEALKARYPGQVTVDYFVDEESSFIEKKSITRFTDTASSNGPPGGKMIIVSGPEGFISYMAGPKLWAQGMELQGPLNGVIKELDLKDWAVWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD26</accession>
    <name>B0YD26_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_094040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094040"/>
    <dbReference type="HOGENOM" id="CLU_050888_0_0_1"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="PhylomeDB" id="B0YD26"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP47560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="324" mass="37461" checksum="85C7D5EE2B82A05C" modified="2008-04-08" version="1">MSSDEIVWQVINQQFCSYKLKTTKGQNFCRNEYNVSGLCNRQSCPLANSRYATVRSDPETGVMYLYMKTIERAHMPSKLWERIRLSSNYAKALEQLDERLIYWPKFLIHKCKQRLTRLTQVAIRMRKIAKEEERLGEKIVPKLAPKIRRREETRERKAESAAKVERAIERELIERLRSGAYGDRPLNVEEGIWKKVLRGLERTGEGERDEDLDDGEEIEDEEEEGVGEVEYVSDLEDDEDLEDIEDWLGGDSADDSSDYDDDEEDEDSDEESGSEEASSDEETKKPKPGAKRKRAAPQVKPRKRGPRVEIEYETEGAGKESILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDC3</accession>
    <name>B0YDC3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_095060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_095060"/>
    <dbReference type="HOGENOM" id="CLU_017444_2_1_1"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="PhylomeDB" id="B0YDC3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="213"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="556" mass="62438" checksum="0D3CB920671B43E3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDU9</accession>
    <name>B0YDU9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096860"/>
    <dbReference type="HOGENOM" id="CLU_2427040_0_0_1"/>
    <dbReference type="OrthoDB" id="4233737at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015308">
        <property type="entry name" value="Bubble"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036334">
        <property type="entry name" value="Bubble_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09227">
        <property type="entry name" value="Bubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103565">
        <property type="entry name" value="Bubble protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760954" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="98" mass="10853" checksum="A0FB8D1CCF92A76F" modified="2008-04-08" version="1">MKFTALLCTLIAATAVSASTVPRDEFQIQDTCGSGYGGDQRRTNRLVWYVNPSQLEDETSFAHGYSFKKVECRNGRWTEIQDCHASTCHGTNDGAARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0YE99</accession>
    <name>B0YE99_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_098430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YE99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_098430"/>
    <dbReference type="HOGENOM" id="CLU_2960306_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="59" mass="6599" checksum="E029BF6A6920EB0B" modified="2008-04-08" version="1">MYRNSEMTARAGSGNNGGNLEVGGWKRQGVEYYLWFYLINHHDEGRGGLVPDPVLPMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEN1</accession>
    <name>B0YEN1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiE/COQ5 methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_099760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_099760"/>
    <dbReference type="HOGENOM" id="CLU_057148_1_0_1"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="PhylomeDB" id="B0YEN1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="269" mass="29910" checksum="22AED4C2674DEF94" modified="2008-04-08" version="1">MSRKDVYITDHAPSVLQTHSWRTASNSAAYLVPYIKPSMKILDIGCGPGSISIDFARLVPQGHVTAIEYVADPLDAARSLASAHGLTNIDFRVGDIHSLDFPDDTFDIVHVHQVLQHIADPVRALREMRRVAKSDGGIVAARESASMTWYPDNAGIAGWKEVTDRMCKAKGSNPHPGRYIHVWAEEAGFQGTRIKKSAGAWCFSSPEERKYWGGSMEARMRSSGFSKMAVEEGYATKEELETIANGWRDFVKDDQAWFGLLHGEILCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEQ4</accession>
    <name>B0YEQ4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoric ester hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_100000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100000"/>
    <dbReference type="HOGENOM" id="CLU_041441_3_0_1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="B0YEQ4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="364" mass="40836" checksum="29D001EA4FB82635" modified="2008-04-08" version="1">MSSPFDRRPLPDYLLSSPLTALLYPLHYILLRLRGPPRLPSPDTHPIRVVCISDTHTLEWDDVPDGDLLIHAGDLCNDGSIREIQAAVDWLQRLPHPHKVVICGNHDSYFDIRSRRDEDRDASSSSFAAISSSTASIRSLDDDPDGLNRINWGDIHYLQHSSITLSFPPPSPAHAAARPRSLTIYGAPQVPAIVPFTSEHAFTYHPQHDAWSGTIPPDTDILITHTPPQAHLDLSPVYSTGCPFLLAETWRVRPALHVFGHVHEAYGCEPVYWDEAQRAWERLCASRRPRARYGRLMSVFGLLRDLFDVHGWLDAMRVVTYGVLGVVWAKVWGGENRGCGWMVNAACMYRNTGRLGNKPQVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0YER0</accession>
    <name>B0YER0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEAD/DEAH box helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_100060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100060"/>
    <dbReference type="HOGENOM" id="CLU_000335_2_1_1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="PhylomeDB" id="B0YER0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
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        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000009">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
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        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="331"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="560"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1192"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1397"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1950"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1950"/>
            <end position="1973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP47404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2043" mass="229146" checksum="1AC55891AC1F41C7" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF34</accession>
    <name>B0YF34_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS pantothenate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_101420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101420"/>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="PhylomeDB" id="B0YF34"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP47147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="475" mass="53155" checksum="F7A89AA072A38587" modified="2008-04-08" version="1">MTILSSSSCIRSSMMRLVPAFHDAESKLRFKIDFFILTFCCITYFFNYLDRANLSNAYVSGMKEELAFHGNQLNVINTIFTVGYILGQVPSNLALTYFRPRIFFPAMIFLWGGLTMITAAVHSPQGIMAIRFFLGLAESSTFVGTHYILGSWYTEEELGKRSGIFTASGLAGTMFGGFIQTGIHSSLDGVRGLSGWRWLFIIDGLITLPIAIYGLFLFPDTPATTRAPYLTESERALAISRLPVTNAERAPLNRAFIKRLFTTWYWWAFVILWVIAGETESFSSNSLLALYMKSHPTIKYSVAQLNNYPTGVPAVGIVSTLFWATLTDILHGKRYLVAYFIGITGVVTAALILTRFDSTPTVFGAYYWAGAVYACQATFFAWCNDAMRSQDARHRSVVLASMNMGNNAVNAWWSIIFYSANLAPQFTRGMWAMIGCSIALVIWASWIVFMMVREKSRPDDGDVRDCSTEQPKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF54</accession>
    <name>B0YF54_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_101610</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101610"/>
    <dbReference type="HOGENOM" id="CLU_031730_1_0_1"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="PhylomeDB" id="B0YF54"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760892" description="AA9 family lytic polysaccharide monooxygenase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="19">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP47167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="364" mass="37478" checksum="4E5556F5A4FE8103" modified="2008-04-08" version="1">MSQTKTLSLLAALLSATRVAAHGHVTNVVVNGVSYAGFDINSYPYMSDPPKVAAWTTPNTGNGFIAPSAYNSPDIICHQNATNAQAYIEIAAGDRIQLQWTAWPESHHGPVIDMLASCGESCTTVDKTSLKFFKIDGVGLVDNSAVPGTWGDDQLIANSNSWMVEIPKSIAPGNYVLRHELIALHSAFETGGAQNYPQCFNLKVTGSGTDSPAGTLGTELYTESDPGLLVDIYKSIASYAVPGPAMYTGAVSITQSTSAITATGTATVGSGADSTPVPSSAASSEYSTVAVQVPTTKAQYTPVPSSSPSTFVTSPAPTTSVPSGSSVPVTSNTAAPLPTAAPGGTQTVYGQCGGQNWTGPTYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-02-06" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>H9CJN6</accession>
    <name>H9CJN6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase chain 6</fullName>
            <ecNumber evidence="2">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_m0140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="3"/>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JQ346807">
        <property type="protein sequence ID" value="AFE02836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_005353055.1">
        <property type="nucleotide sequence ID" value="NC_017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CJN6"/>
    <dbReference type="GeneID" id="11948079"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1200:FF:000008">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="entry name" value="NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269:SF17">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFE02836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="216" mass="24251" checksum="C3D9DD6DACA6CA99" modified="2013-02-06" version="1">MNNIFLLNDYITNGFRIEFVDMIYLISILFGVLTIVSRNPIVSVLFLIGLFVNIAGLLILVGYNYIGLSYILVYVGAVSILFLFILMLINIRISELLSETNNDIPLAVLTVLLFYYIVGQVLPSNLTDNTIVSYLSNSFSEVYNVQLDNEFFNIVDLKQEIAYASSKGWDSSLVEFTHITGIGNIMYTSYSIWLIISSVILLLGMVGAIVITIKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM81</accession>
    <name>B0XM81_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UPF0023 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_001210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001210"/>
    <dbReference type="HOGENOM" id="CLU_043216_1_0_1"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="PhylomeDB" id="B0XM81"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990932">
        <property type="term" value="F:5.8S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="110"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP55429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="344" mass="37259" checksum="F8853B49C476759B" modified="2008-04-08" version="1">MPINQPSNQIKFTNVSIVRLKKGKKRFELACYKNKLLEYRSGAEKDLDNVLQVPTIFLSVSKAQTAPSAELTKAFGPNVSADEIRQEILRKGEVQVGERERKEMLERVEKEVLDIVSGRLVDPNTKRVYTPGMISKALDQLSSASGQQQMQQEGNGNGNGAGDENGPAQPRKPLWTGVTPNKSAKSQALEAMKALIAWQPIPVMRARMRLRVTCPVALLKQSVKAAAAPGPNKEREGPSGGAKNNKKGGKGGKGKAVRQQDSDVEAGGSDAEMAPALKAPTNVKDRIMSFIESVESQEVVGGDEWEVVGFAEPGAFKGLNEFIGTETRGRGRVEVLDMAVTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM83</accession>
    <name>B0XM83_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_001230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001230"/>
    <dbReference type="HOGENOM" id="CLU_1230293_0_0_1"/>
    <dbReference type="OrthoDB" id="5408144at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="221" mass="24192" checksum="FDD3084506AB448F" modified="2008-04-08" version="1">MNFKDRFRKVFHRHSNGHSSSNSKSISKSKSNGNGNGIKIEYYKRGEIPPSKFRGPFDPEHQKRLAAWSFEAAQAERPRALDPPLSPCTTLSQYLDPHHGESEDESVAPDQICETAPPEVGLLDSSATVSHHEYAPGRQEESSGSSSSTAVESSSYSNSSMTLYSDDARMDSIAQIKESVRYTSPMLRAVSPPPPTSTKGTLMPFSPDDLTRALNAVQICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMG7</accession>
    <name>B0XMG7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_000190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000190"/>
    <dbReference type="HOGENOM" id="CLU_1331663_0_0_1"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="PhylomeDB" id="B0XMG7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="206" mass="22680" checksum="C1C28C94816D5733" modified="2008-04-08" version="1">MPSRRSHSKSHHGCTQCKGRQIKCDEVRPICGSCRRKQLPCNFQSFAPQTSPQPSIADAILGHRDSFVLPLLDLELLHHWHTVTGNYLADAKPLQDVIRTVMPQEGLANPFLMHSILAVSALHRAHSAPLSHRQILCIRVSEPKQKPEDPKSDRSGRSVQVSSWGRLCREPGQIVARTRTLAALAADWSVSNADSNSGRTLCSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMV8</accession>
    <name>B0XMV8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="5" type="ORF">AFUB_003470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003470"/>
    <dbReference type="HOGENOM" id="CLU_094325_1_0_1"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="PhylomeDB" id="B0XMV8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="167" mass="17897" checksum="AD3D656A1FB46D14" modified="2008-04-08" version="1">MTEGKSSAQPDQVFTSADRIRQLNEVDKDVAKLIHSAGLAIQALTNARTGDSPEDTSLESHKARFKEATSQYFALLSSIDVRLRRQVYALEEAAILAPESASRTGDLPGAGVGGTVVSNPLDVSWLNSRKDTVGKDKEAELWAAARQFVEQLGDSSAAGVKTEDGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMW1</accession>
    <name>B0XMW1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_003500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XMW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003500"/>
    <dbReference type="HOGENOM" id="CLU_028296_1_0_1"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="PhylomeDB" id="B0XMW1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="527" mass="58980" checksum="3E9E5122BF6E4AD8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN05</accession>
    <name>B0XN05_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Probable quinate permease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Quinate transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_003940</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_003940"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="PhylomeDB" id="B0XN05"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF20">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="40"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP55697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="563" mass="61311" checksum="86D6BB95B9C77088" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0XN13</accession>
    <name>B0XN13_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_004020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XN13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004020"/>
    <dbReference type="HOGENOM" id="CLU_063074_0_0_1"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="PhylomeDB" id="B0XN13"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="33"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="282" mass="32101" checksum="7A4F309AB262057F" modified="2008-04-08" version="1">MQASEGRRKMEALLEGGRPVKHVSRKALYTRLEARITYLKDFLDFNSSDIEALTTGSKYIKALIPAVVNIVYKKLLEQDITARAFITRNTADETTNVDDWYTEDSPQIKRRKMFLRWYLTKLCSDPTEMEFWRYLNKVGVMHSGQERRLPLNIEYIHIGVMLGFIQDVFTEALMSHPTLSLQRKVALVRAIGKIIWIQNDLFAKWRVRDGEEYADEMSEIILDDKEGYIGEKKILGDSSPSASSSDDDRSSIASSVAPSAASACPFSDMARPSSETKIWAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNF2</accession>
    <name>B0XNF2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_004730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004730"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0XNF2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000115">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="527" mass="59977" checksum="26ADE3CFE8F20424" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNF4</accession>
    <name>B0XNF4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CUE domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_014950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_014950"/>
    <dbReference type="HOGENOM" id="CLU_026011_0_0_1"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="PhylomeDB" id="B0XNF4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CUE" evidence="6">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="268"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="8">
        <location>
            <begin position="419"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="493" mass="55240" checksum="F093EA1FA2DB1015" modified="2008-04-08" version="1">MFVASSSSPSTAPGHNLGLILKSDGCRMDRFISRKRPRPSPSAGQQTPAPDEDSTDMKLAMLLSLFPDIEQDALLDILISSGGSVEDASAVITAQRAYKPVKKRAGGVSAIQTSMTSHITTEAGLPPKRQLTRKGKTLHLFSPEDVAAHTPCSIIHNFLPPDEADALLLELLDESKHFSRYRFQLFDRTVESPHTSSLYVATPEEIRQQTSEYTYGGRYRSNVRQLTPYLRAVSAKVQRAVNDEVQKRIRACYPGGKKLKYQSPKEWVPNAAFVNCYDGPAESVGYHSDELTYLGPRAIIGSLSLGVEREFRVRRIVASDDDAENNSEVSFMVSTADSPSRRKTTSKGIDGRGDAQGQISIHLPHNSLLVMHAEMQEEWKHAIVPAQTVSPHPLSGNRRINITYRWYRDSLHPRNIPRCRCGTHAILRCVQRKRENKGRYMWMCYAGHEPGKKGCTFFQWAEFDDDGEPLWEIKPTEGGAPTLRNFIEEDDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNU4</accession>
    <name>B0XNU4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_015690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015690"/>
    <dbReference type="HOGENOM" id="CLU_099931_1_0_1"/>
    <dbReference type="OrthoDB" id="2999773at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="213" mass="23410" checksum="26F7318E53DF5383" modified="2008-04-08" version="1">MHSITSQNNNAGTLPPPPPPPPPPLSAGVVPAPASAPQPEPPTVAEQGPPGAFLVELLIYNGHPFKDHWAYWVRSHTDKDLGVKIHATGDVRNGFEFEIKRSSNFRTNELPPTKRIPLQWVYGQYFDEKAMSNNGEHKIDNVPVCQFEASAHKIKAPGKSLNTTSDASSSAGNVGKKVTQRNCQTWIVESAEQLVKDNIIRREIADYLCAIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNW7</accession>
    <name>B0XNW7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF455 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_015920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015920"/>
    <dbReference type="HOGENOM" id="CLU_1643302_0_0_1"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042653">
        <property type="entry name" value="Leng9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729:SF1">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="2">
        <location>
            <begin position="61"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="153" mass="17135" checksum="AA44AF94140BDBC0" modified="2008-04-08" version="1">MASDLSAVSQEHKTGNNSATSAQTEDISSSSPAAITHSEANESLDHASSTSKTSTSAENRLRPAADVINRLIWDTKFDSNDYTIGYEDRFNGRLEANLSSWKKDLTDEEFIPQHRILYIKRKSDGEIVWDKRRRTDKIFLSGNSAFNFLGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPA9</accession>
    <name>B0XPA9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS lactose permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_016690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016690"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B0XPA9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF36">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="573" mass="63177" checksum="C1C72010783ED007" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPD2</accession>
    <name>B0XPD2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_016930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_016930"/>
    <dbReference type="HOGENOM" id="CLU_009388_4_1_1"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="328"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="793" mass="90443" checksum="544FEFB02D62CEE9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPH0</accession>
    <name>B0XPH0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LMBR1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_006450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006450"/>
    <dbReference type="HOGENOM" id="CLU_016542_1_0_1"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="PhylomeDB" id="B0XPH0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="681" mass="76020" checksum="F43FD101D28ED37E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPL2</accession>
    <name>B0XPL2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_017060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_017060"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_6_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="PhylomeDB" id="B0XPL2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000597">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP56983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="544" mass="60159" checksum="B6E56194977B1F10" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPT8</accession>
    <name>B0XPT8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_007540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007540"/>
    <dbReference type="HOGENOM" id="CLU_1224500_0_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="219" mass="25485" checksum="615F4DB33C5FB64C" modified="2008-04-08" version="1">MATYETDPEIGFDQDDPRYWRALHVNLHHAIMENDIAEVKRLLSLGADINVKTEHGYNALDWADHLKHLEVAKCLLHNMNIKLHGYVEILKHIRAKHPIIVRALLEMGVTGMLAKNKRFHRGMILQACRIGHPTILQMLINCLPGYMITEYKQVYLQVAASEHNDDVLEILRARARQEEAWRENYFRPKTSVTPVQLPPRDLEYEKIFDEYINPGAYLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPW9</accession>
    <name>KAD2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">adk1</name>
        <name type="ORF">AFUB_007850</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="1">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and disassembling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPW9"/>
    <dbReference type="SMR" id="B0XPW9"/>
    <dbReference type="EnsemblFungi" id="EDP56083">
        <property type="protein sequence ID" value="EDP56083"/>
        <property type="gene ID" value="AFUB_007850"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007850"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="PhylomeDB" id="B0XPW9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000365660" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <sequence length="257" mass="28703" checksum="FC9E0BE849D5BBEB" modified="2008-04-08" version="1">MAPITEEVVHGLKDMIEKLENRVQELEARLGGESKPKSIAEQMRIVLMGPPGAGKGTQAPRLKEKYCVCHLATGDMLRSQVAKKTELGKEAKKIMDQGGLVSDEIMVNMIKNELDTNSECKNGFILDGFPRTVAQAERLDDMLEARNQKLQHAIELQIDDALLVARITGRLVHPASGRSYHKIFNPPKNDMKDDVTGEPLIQRSDDNAETLKKRLSTYHAQTAPVVEYYKKTGIWRGIDASQEPGQVWKSLLGVFQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR88</accession>
    <name>END3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Actin cytoskeleton-regulatory complex protein end3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cytoskeletal adapter protein sagA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">end3</name>
        <name type="synonym">sagA</name>
        <name type="ORF">AFUB_012500</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
        <text evidence="1">Cytoplasmic and cortical actin patches.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR88"/>
    <dbReference type="SMR" id="B0XR88"/>
    <dbReference type="EnsemblFungi" id="EDP56539">
        <property type="protein sequence ID" value="EDP56539"/>
        <property type="gene ID" value="AFUB_012500"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012500"/>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="PhylomeDB" id="B0XR88"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000323">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein end3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0254">Endocytosis</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000349437" description="Actin cytoskeleton-regulatory complex protein end3">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="EH 1" evidence="3">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EH 2" evidence="3">
        <location>
            <begin position="139"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="281"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="404" mass="46489" checksum="0D7EB5CBCE46EF23" modified="2008-04-08" version="1">MSNKKIEQWEIERYWEIFSSLANGHPRLNSSQAASVLRNSRLSDDQLEKVWDLADVDSDGELDFEEFCVAMRLVFDLVNGELQAVPRVLPDWLIPETKAHLVQAGRALSDRPEQFERIEDEDDTPGLKDGFDWYMKPSDKSKYEEIYSANRNHRGEITFESLQALYDSLDVPDTDIRSAWNLVNPSASPAINKDATLAFLHILNYRHEGFRIPRTIPASLRASFENNKIDYQIDNARPAQRWGADGDTETPTGRKAKFGDTYLSRLGVGGKGSYTPKGTDFSDTIQDEEWEKVRLRRELSELQAKLEAANKASESRRDRPRNDGRPNWTLIKKEALQLLEYKERELRELREGTGRAKAGQDLERLREDIRTVGEQVEGLKSHLAQRKEVLADLRSQIEEERARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRC9</accession>
    <name>B0XRC9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase CipA-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_002030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002030"/>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="B0XRC9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="42"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="359" mass="40474" checksum="561D460B2E8F9847" modified="2008-04-08" version="1">MTQNDTPRTSYSDPSHPIQYLDNMAQKYARDQPSGFTNRIERVAIVGAGGTVGKYITQELLKTGQHTITALTRADSQSTLPAGVRTATVDYQDESTLVAALQDQQFLIITLNVSAPKDTQSKLIQAAAKAGVPYVMPNCYGCDITNEKLRKEMLVGEPVRQACAEIEATGVSTWVALVCGFWYEFSLSTGPEWFGFDFQQKKLTFYDEGTVRINVSTWEQCGRAVAAFLKFKELPEDENDTSPTVRGWANRPLFISSFLVSQRDMFESWKRITGDKEEDWTIEYEPTAVRYQRGIERMQKGDRYGFAQAMYARVFYPNGGGDYESSRGLDNDVLGLPQEDLDERTKHAKEMIEAGYSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRD3</accession>
    <name>B0XRD3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formaldehyde dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_002070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002070"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="PhylomeDB" id="B0XRD3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070458">
        <property type="term" value="P:cellular detoxification of nitrogen compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="145"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP55512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="464" mass="50359" checksum="944A62A83B041834" modified="2008-04-08" version="1">MDRVECVCVCVLVRCLCQQQEKKSIPLSTPLDSLQYQPWSSEVDKCNPLLQTSDRILETRQNDEAALTLSIPPSNPESDIQSTNDDRNSQVKLPQASSKPPTNRIRPMTSTLYKPHPTEQMKAAQWMGTRLIQLDTVAKPTITDPADAIIHITHCTIGGADLHLYDGELSDMLAQGDILGHEAIGTVEDAGEAVRSISPGDRVMILPVIACGHCEFCKRQEFSLCDTTNPSREMESAYGHRVAGMLGFTRLYGGYPGAQAEYVRVPHADFCCVRVPADMDAKELLGLAHVTTAAWHGCELADVQPGDTVGVWGCGPVGLSVQRLAVLRGATKVYAVDKDAGRLQIAEGFGMIPVDVGVHSEVGDYILSMEPRGLDCAVEASGFRSTQKPQHAAMRAIGLEHDSSDTVSAMIKATRKGGHLALLGDFFYRTNDFPIGPLMEKGLTIRGGQVNSQKAFTVADMRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRL9</accession>
    <name>B0XRL9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_013140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013140"/>
    <dbReference type="HOGENOM" id="CLU_2263147_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP56603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="103" mass="11339" checksum="687474AEE72D6F20" modified="2008-04-08" version="1">MSPRLQPSTYDHRVWKTGLPVRSTVLKPGVECGQSIESPFASKAAAGCFSPLMHHEALLYATKWKIRQTGDDGIAGKYAICFKRKHHPAGGPDGFQEMIDLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRM3</accession>
    <name>B0XRM3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_013180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000310_0_1_1"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="PhylomeDB" id="B0XRM3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001025">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="604"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1298" mass="146116" checksum="F2CE960C73F1A4D0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRQ1</accession>
    <name>B0XRQ1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_013470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRQ1"/>
    <dbReference type="HOGENOM" id="CLU_018249_1_0_1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="PhylomeDB" id="B0XRQ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760107" description="ASST-domain-containing protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="67481" checksum="4578EE9BA968EF25" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRR0</accession>
    <name>B0XRR0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation protein BIR1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_013560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRR0"/>
    <dbReference type="HOGENOM" id="CLU_010318_1_0_1"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="870" mass="97523" checksum="9F8403A01BBC4923" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS23</accession>
    <name>B0XS23_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_025660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS23"/>
    <dbReference type="SMR" id="B0XS23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025660"/>
    <dbReference type="HOGENOM" id="CLU_089407_0_0_1"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="PhylomeDB" id="B0XS23"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP54509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="237" mass="26788" checksum="AAF54BD543FBEEC0" modified="2008-04-08" version="1">MMSPHLLPSTSIPKASAALLLRPAFPRMTTLTRFYATQSDLGGGSGSKATPRRRNVTVLSDDGRYEWGELSGREKVARATQQSLNFLVIVAGAVLTGGVFYLLYTEVFSPNSRTWQFEKAVQRIKDDPRCTDLLGDRREIKAYGESTGSRWERNRPIATSMFKDRQGREHMKMHFHVEGPLNSGIVIVHMMKPLDKDEWEYLLLALDVKGHSRVILEQAQEKPGVAKALKIFGIQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSI4</accession>
    <name>B0XSI4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ergosterol biosynthesis protein Erg28, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_027300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027300"/>
    <dbReference type="HOGENOM" id="CLU_114589_0_0_1"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="PhylomeDB" id="B0XSI4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="141" mass="15627" checksum="E4CF4904FBAAF5D2" modified="2008-04-08" version="1">MTSLLSYLPPFEGLLPKWLVLVSVVSAINSLQCYRSDEYAAQLYNARTADGRSFATPLSSRTFGTWTFLSAVVRMYAAYHITTPAVYDLAVWSFGLALAHFVGEWLAFGSAQLKGRFVSPLIVASVTLTWMLTQREAYLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSS9</accession>
    <name>B0XSS9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_017480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSS9"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_0_1"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="PhylomeDB" id="B0XSS9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="352" mass="39597" checksum="3F78EB05DB780D77" modified="2008-04-08" version="1">MNPISQLILSLDLPSNTCTPTINPDANGWVPATECNALYNYYPSFGVAIAFSVLFGVLMVPHFIQATVYKAGFVWFIVMSAAWECVGFVVRTLSTREQQDNTLATITQLFILLSPLLEGVNAFDYMVLARMIHFFVPDRRIGIFKPSMLAMIFVVLDLGSFVIQLTGGSMAGAGADHDTMMKGIHIYMGGIGIQEFFIVLFLFIAIQFHRQMLHLNRHGRLVGPKAKWRGLLYALYASLLFITVRIIFRLVEFSSGNDASNPILQHEWYMYVFDAVPMWFAIVVWNVVHPGAIIKGPDAKMPPSPLRKILCCAFCCSGCRKRKNKDMQMIPDNDHLGDETLPLRERAASPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>B0XT84</accession>
    <name>B0XT84_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_018370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018370"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B0XT84"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="10"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2517"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1015"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP53793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2609" mass="288790" checksum="FD625259014D5AF2" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTJ6</accession>
    <name>B0XTJ6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_018810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_018810"/>
    <dbReference type="HOGENOM" id="CLU_032158_1_1_1"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="PhylomeDB" id="B0XTJ6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="437" mass="46116" checksum="A12B0312B5AA9DEC" modified="2008-04-08" version="1">MTIETLREISSHNLRTFQNHYVSEVSGSLGDLGTFLPIAIALAVNGTVSLSSTLIFSGSFNILTGLFFGIPLPVQPMKAIAAVAIARSFSNGTIAAAGIFVGACILFFSVTGLLHWFANAIPIPVIKGIQVGAGLSLVIAAAGKTLAPLGWLQPSWADNRLWAIAAFVFLLFTNVYRTVPYALIVFALGLAFALVLSTVAADLPSLEIWRPFVVMPGVSEWKVGALDAGVGQIPLTTLNSIVAVVHLAGDLLPRVKTPSITAIGLSVAGMNLVGCWFGAMPVCHGSGGLAAQYRFGARSGSSVIVLGLLKLLIGVFFGETLVGLLKRFPSALLGVMVIAAGLELVSVGESLNTTGARDIAGFGQGLTGDSEHEIGPMLSDIERKRRWAVMMVTVGLLVGFKNDAIGFVAGMLCHWGFQLPWAFERARARWSEGRIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTP0</accession>
    <name>B0XTP0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Splicing factor 3B subunit 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_029410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTP0"/>
    <dbReference type="HOGENOM" id="CLU_002242_0_1_1"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="PhylomeDB" id="B0XTP0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="259"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="794"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="1031"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1246" mass="138049" checksum="24D9EF1EB305E4D4" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTV7</accession>
    <name>B0XTV7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_019250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019250"/>
    <dbReference type="HOGENOM" id="CLU_070360_0_0_1"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="PhylomeDB" id="B0XTV7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="66"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP53879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="347" mass="39480" checksum="7261502E4190B621" modified="2008-04-08" version="1">MTPSAKSPIRAEDQQRANSVTVTHPGAIIMGTWEDFDSIFYFNKSFNYDDKVIEQILSNRRALGNQLFADRLLGLLGVQAVKQLYPPRSNADLRALVNHIVSSALDIHHKQALIYYILKDCRAASDAASQFARRCHLPEKYRLFIEGLWNLDRLELRRAIEYLTEPSIIPTFPDEILYVLTLPQLPKHDDNLAMAYYLTVTPPLASEKVQKAFFEILCRSSITEAFYFTRKRDESLRRAYLEQLIEFVLKTSPGQMRSQRAMELISLPLDNTEEEWFEEALLRGCAKTLHGAKDTAMMRRFATGKLDALSPELESLGGKKIDGLDWDALRQSVRTAHTSVPTASGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTW2</accession>
    <name>B0XTW2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">AFUB_019300</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_019300"/>
    <dbReference type="HOGENOM" id="CLU_000537_6_0_1"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="PhylomeDB" id="B0XTW2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000560">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
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    <keyword evidence="17" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="285"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="83"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="477"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="582"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1346"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1348"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="1365"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP53884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1421" mass="159540" checksum="FC08C06F6EC7D09E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUB9</accession>
    <name>B0XUB9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_020190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP53973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="311" mass="34971" checksum="1BAF99AC3F66BA78" modified="2008-04-08" version="1">MGAENQQIMRYDIIQKQAVAALMNEVEKENKEPVKGHGNRAGSWAQIAGSMTKVQCQPKETLHYLSPMSMSSVSGSKQSHSIDGENGARAMNFSGAPLSPEIAEAKAGVVRIYGRVTREAIRFVTTRIHEGPLQEIRIETNERTRVTFQYASHALAFVKSNQDMEEMLGYGRFGTGYTVEMAEIINWNDEHRRMNQPIRERRRLSFARKRLFADNMSPEKWKSDVRAVAGLGNIDFLWVFNSGNATAVFTSTAVARRVLEAFNKWKDTRAVYSGVSVTYSSDPCEKELVLVNDTARSGFAKNLNFAKKSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUH8</accession>
    <name>B0XUH8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_030940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_030940"/>
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    <dbReference type="OrthoDB" id="2799468at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007011">
        <property type="entry name" value="LEA_SMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04927">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP" evidence="1">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="189" mass="20258" checksum="66C77F7B7340BB36" modified="2008-04-08" version="1">MSFDLPSVSELKRAAEVGQRITPEDVSVIAQAESELTGKGPVRGGPAVENRRAFDVDRALATAQSLAMRQMNFDTKLDEISRKPQSHITQEDAREIQATEVFKGRAFNKPPGAGSVAAQVRSIANRNEALGLPPINAGVAAYVTKDDAREAQRAESFVYGGQNPSGGMAAQMQVSGMAGWAWVIRLTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVQ2</accession>
    <name>B0XVQ2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1,3,6,8-tetrahydroxynaphthalene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_033250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVQ2"/>
    <dbReference type="SMR" id="B0XVQ2"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="B0XVQ2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP55260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="273" mass="28843" checksum="B5F610612AFA41ED" modified="2008-04-08" version="1">MVNTCTYLPLSGKVALVTGGGRGIGAGIALELARRGASVAINYGHSAKSAQEVVEAIQAIGRQAVAIQADLTCVPNIESLIQEVVRHFGRLDIVVSNSGMEKFKPLEETTLEDFNEVFNLNTRAQMFVARYAYDHIQPGGRVILMSSIAAGLGVPGHALYAGSKAAIEGFTRCLAADFGRKGCTVNAIAPAGVKSDMWRENAWRYAPGCDKSSSLEEIETALASGSPLKRCGVPEDIGKVVSFLASPDAEWVNGEFFSPPPCKGPLPGGDLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVV6</accession>
    <name>B0XVV6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_022920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_022920"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="PhylomeDB" id="B0XVV6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="54"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="562" mass="61122" checksum="7ADB4B2D36364A03" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWC1</accession>
    <name>B0XWC1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_024290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024290"/>
    <dbReference type="HOGENOM" id="CLU_055475_0_0_1"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="415" mass="45595" checksum="A466A3F09E7DBDA1" modified="2008-04-08" version="1">MAASFTCHGAILPSGNAHMSHSHHGSHSIHVDEATLASSITTTTSTPTISPSTTFALTPGHDQPASYLAVSTWPPLNFTTRAISPCLSDISETKTFYSTVEVTEICADACDSPIALDLTSNGCLDQMENCLTHAVGQPDTTTVTPSTPTSNSHRTPKRKRTVSPPSSAKSPEHLRSTSRSTRRTTPTSRRSSLHSHRRAATTSLTPSVVDRKDPVAKREDLLALHREACRLFQDNELQQSYLQKRQSPPAPCAPCARRASSEFSSPSASPIAYTHFSTSAREPGLDTSLSPDHPTYRPAANSVAGGASKQVMSTVIDWTSPSTRRREYKKIDRASNGVRGFWRRVAPRWCQFGDNRMPFFREGKNGKGNYEGSVRRFRMDLPDEPVDETANRSRRGLKFKKKLTVHGFTPRRSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWD5</accession>
    <name>B0XWD5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_024430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWD5"/>
    <dbReference type="SMR" id="B0XWD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024430"/>
    <dbReference type="HOGENOM" id="CLU_003041_18_0_1"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="PhylomeDB" id="B0XWD5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="194"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="455"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="631" mass="70437" checksum="E9E5A0276F808200" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWV2</accession>
    <name>B0XWV2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_036520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWV2"/>
    <dbReference type="HOGENOM" id="CLU_024519_1_0_1"/>
    <dbReference type="OrthoDB" id="5280838at2759"/>
    <dbReference type="PhylomeDB" id="B0XWV2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="60684" checksum="E6CD244C43BAD3F5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWX6</accession>
    <name>B0XWX6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_036760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_036760"/>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="PhylomeDB" id="B0XWX6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090726">
        <property type="term" value="C:cortical dynamic polarity patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180040">
        <property type="term" value="P:negative regulation of pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="181"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="206"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP52510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="359" mass="41397" checksum="CA1307C3019E1204" modified="2008-04-08" version="1">MGCMSSKQAEAADKEALQRTIRIDKSLKNDKKLMDRTIKILLLGAGESGKSTIIKQMRIIHSGGFPEDERRQTRAVIYSNLVIAFKVLLDIMRAEQIDFELETTKQLAEFIDNLEPDVGSDEAFSDYKVRDAMREMWVDAGVQKAVSRGHEFALHDNLQYFFGSLDRLFKPGWLPDNQDMLQARLRTTGITETLFELGQMNFRMMDVGGQRSERKKWIHCFEGVQCLLFMVALSGYDQCLVEDQNANQMHEAMMLFESLVNGEWFKRKPIILFLNKIDLFKGKLEFSPVSKHFPDYNGSNSDFDAAARYFADRFRGINRIPDREIYIHYTNATDTTLLKATMESVQDMIIQKNLHTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXU8</accession>
    <name>B0XXU8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein serine/threonine kinase (Ran1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_038630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_038630"/>
    <dbReference type="HOGENOM" id="CLU_000288_172_3_1"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="PhylomeDB" id="B0XXU8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="41"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP52694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="423" mass="46792" checksum="86F34323A384BA97" modified="2008-04-08" version="1">MLTLNPFGMYPPMLPTPPPSPPTTRVHAPEDRLGYLLANRLELTSILGVGAYGVVYTAVDIHTNVVYAVKALNKVGLDARQLKFQQREIKLHHLASQHPNVVSLVRIMDSVDCTYVVIEFCPEGDLFSSITEKGNFVGNDPLVKRVFLQILDAVQYCHSLGIYHRDLKPENILVTDQGLTVKLADFGLATTDYFTSDFGCGSTFYMSPECQQPNPRPLSCYASAPNDVWSLGVILVNLTCGRNPWKRASIEDSTFRAYLKDPYFLKSILPLSDDLVCILSRIFECDPSKRITIPELRQLILDCPQFTLNPVIPWVAPHGPLPYDVISGPQVPVSVPVHAFNPQPSTSSSDSSHYSNYSESAASDSSCYTEVFTDMDSVPSMSSVEYEPETDCRGDLSLDSLTCKDISEAIVVHQSDPQTLCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0XXY6</accession>
    <name>B0XXY6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_039010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XXY6"/>
    <dbReference type="HOGENOM" id="CLU_011910_0_0_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="B0XXY6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="874" mass="99316" checksum="0DB364AFBC27DB4C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYL4</accession>
    <name>B0XYL4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_041320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYL4"/>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_1"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="PhylomeDB" id="B0XYL4"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="349"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="440" mass="49308" checksum="C19C48758A8506F4" modified="2008-04-08" version="1">MVQYNQSLPYDRIFWKQDIAGSIAFARANTKSGILTQHEFSEIERGFKQIAEEWSTNTFVVKESDEDIHTANERRLSEIIGKEIGGKLHTGRSRNEQIATDMRLWLRDELRKLDAVLCDLIKVSIARAEKELDFIMPGYTHLQKAQPVRWSHWLLSHATAFASELQRLREVTRRVNRSPLGTGALAGNPFQIDREAMAAELGFDGLLYNSMNAVADRDFAMETMQWGSSFMLKISRWAEDLIIYSSLEFGFVRLSDAYSTGSSLMPQKKNADSLELLRGKAGRAFGHMAGLMMTIKGLPTTYNKDLQESVEPLLDHIKTVSDSIQIATGVLSTLTVLPEKMTAALAPEMLATEIADYLVRKGVPFREGHHISGRVVALAEKNNVPMDTLSLEQLKAIDARFDEDVQACLDYERAVELKDAVGGTSRRAVLEQTAVLRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYR8</accession>
    <name>B0XYR8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polysaccharide deacetylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_041850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_041850"/>
    <dbReference type="HOGENOM" id="CLU_022194_1_0_1"/>
    <dbReference type="OrthoDB" id="2128708at2759"/>
    <dbReference type="PhylomeDB" id="B0XYR8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760721" evidence="7">
        <location>
            <begin position="25"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="240"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="452" mass="51553" checksum="3D1582A2016C1076" modified="2008-04-08" version="1">MDLQGHLKWTGLISILSLMSLVNASPSITSTQNTNISACQQHAGLQSNDNTRNTRKVSLLNGLHHQPPLVIDTFNDAWRNNLGFWHGAGEGLPFEYGNGYVRFFPTDPDHNYHTQLAAAECFSLLPYSDQYLHVVFSGTNKFSISLNQNNEDCDPYRKPYPETWDSVEASRYTSGNEIYVPLSHFHIDQSRVLSISFNGFYSKESLTLYKVEIVPELPMGLRVPNRLANGRMVLRCTRPNSFAFGIDDGQPCFAQEVMAILQKENILVTFFVVGSGLRDEETNFTQVYREMLRRGHQIALHSNTHRKMEGLEAIEDIDDEIIRNIRAFGSFLGVESRYFRPPFGTIGSRTRQRLAVYTSDPQIVNWSVDIEDWLWGDTETPERQLEAFYRDVRRGGNLAVMHYLKPSTVKYFPQVIRFVKAMNLTIMRIDQCLEDPSSPPLRVGRLNAISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZF4</accession>
    <name>B0XZF4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044220"/>
    <dbReference type="HOGENOM" id="CLU_089032_1_1_1"/>
    <dbReference type="OrthoDB" id="5428321at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="210" mass="23877" checksum="2E5A62CC32DDF643" modified="2008-04-08" version="1">MAVKDNHNQKRSDWRLICRKRLAHHIAESLGIHIKSSEVRLKVEEDAPYAWHIEDPSLEPLFSKQLSKHSVGVYMQLCAEVGRSFWAVRAHALTGTTQGLSLDEQIKVLRSENTALSKELQTVKQDVQELQQRNQTLEKEAVDMKELLSSRNLVIDGYEREIQKLRSQAAVYQASYLQCSEALNQATLYLQGLHSDIMASIPGIQLMTPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-11-27" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZV0</accession>
    <name>SPHH_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450 monooxygenase sphH</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Sphingofungin biosynthesis cluster protein H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sphH</name>
        <name type="ORF">AFUB_034460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Antibiot." volume="45" first="861" last="867">
            <title>Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.</title>
            <authorList>
                <person name="VanMiddlesworth F."/>
                <person name="Giacobbe R.A."/>
                <person name="Lopez M."/>
                <person name="Garrity G."/>
                <person name="Bland J.A."/>
                <person name="Bartizal K."/>
                <person name="Fromtling R.A."/>
                <person name="Polishook J."/>
                <person name="Zweerink M."/>
                <person name="Edison A.M."/>
            </authorList>
            <dbReference type="PubMed" id="1500351"/>
            <dbReference type="DOI" id="10.7164/antibiotics.45.861"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2022" name="ACS Chem. Biol." volume="17" first="386" last="394">
            <title>Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor.</title>
            <authorList>
                <person name="Bissell A.U."/>
                <person name="Rautschek J."/>
                <person name="Hoefgen S."/>
                <person name="Raguz L."/>
                <person name="Mattern D.J."/>
                <person name="Saeed N."/>
                <person name="Janevska S."/>
                <person name="Jojic K."/>
                <person name="Huang Y."/>
                <person name="Kufs J.E."/>
                <person name="Herboeck B."/>
                <person name="Guo H."/>
                <person name="Hillmann F."/>
                <person name="Beemelmanns C."/>
                <person name="Valiante V."/>
            </authorList>
            <dbReference type="PubMed" id="35023724"/>
            <dbReference type="DOI" id="10.1021/acschembio.1c00839"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of sphingofungins, bioactive molecules acting as sphingolipid inhibitors via inhibiting serine palmitoyl transferase (SPT) (PubMed:35023724). Within the pathway, sphH catalyzes the conversion of presphingofungin into sphingofungin B1 via hydroxylagtion at position C-14 (PubMed:35023724). Sphingofungin biosynthesis starts with the PKS sphB that produces an C18 polyketide precursor 3-hydroxyoctadeca-4,10-dienoyl-ACP containing one delta-6 desaturation and one delta-12 desaturation. The aminoacyl transferase sphA uses the sphB product to produce 3-keto-presphingofungin by adding an aminomalonate molecule. SphF then reduces the C-3 ketone of 3-keto-presphingofungin which leads to presphingofungin. The cytochrome P450 monooxygenase sphH converts presphingofungin into sphingofungin B1 which is further converted to sphingofungin B by the dioxygenase sphC. SphC is also able to convert presphingofungin into sphingofungin B2. The acetyltransferase sphE acetylates sphingofungin B to produce sphingofungin C, but can also convert sphingofungin B1 into sphingofungin C1 and sphingofungin B2 into sphingofungin C2. Finally, sphingofungin C can be spontaneously converted into sphingofungin D (PubMed:35023724).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>presphingofungin + 2 reduced [NADPH--hemoprotein reductase] + O2 = sphingofungin B1 + 2 oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:81163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:231805"/>
            <dbReference type="ChEBI" id="CHEBI:231806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:81164"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is positively regulated by the sphingofungins biosynthesis cluster-specific transcription factor sphG.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to the accumulation of sphingofungins B2 and C2, noth lacking the C-14 hydroxyl group.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="3">The sphingofungins A, B, C, and D, show a limited antifungal spectrum of activity but are especially effective against Cryptococcus species, fungal pathogens causing opportunistic infections in human.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZV0"/>
    <dbReference type="SMR" id="B0XZV0"/>
    <dbReference type="EnsemblFungi" id="EDP52282">
        <property type="protein sequence ID" value="EDP52282"/>
        <property type="gene ID" value="AFUB_034460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034460"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B0XZV0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000461291" description="Cytochrome P450 monooxygenase sphH">
        <location>
            <begin position="1"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18404212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="35023724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="35023724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="35023724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="543" mass="59913" checksum="18A210A8DCA2C61D" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-11-27" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZV4</accession>
    <name>SPHD_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS-type transporter sphD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sphingofungin biosynthesis cluster protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sphD</name>
        <name type="ORF">AFUB_034500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Antibiot." volume="45" first="861" last="867">
            <title>Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.</title>
            <authorList>
                <person name="VanMiddlesworth F."/>
                <person name="Giacobbe R.A."/>
                <person name="Lopez M."/>
                <person name="Garrity G."/>
                <person name="Bland J.A."/>
                <person name="Bartizal K."/>
                <person name="Fromtling R.A."/>
                <person name="Polishook J."/>
                <person name="Zweerink M."/>
                <person name="Edison A.M."/>
            </authorList>
            <dbReference type="PubMed" id="1500351"/>
            <dbReference type="DOI" id="10.7164/antibiotics.45.861"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2022" name="ACS Chem. Biol." volume="17" first="386" last="394">
            <title>Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor.</title>
            <authorList>
                <person name="Bissell A.U."/>
                <person name="Rautschek J."/>
                <person name="Hoefgen S."/>
                <person name="Raguz L."/>
                <person name="Mattern D.J."/>
                <person name="Saeed N."/>
                <person name="Janevska S."/>
                <person name="Jojic K."/>
                <person name="Huang Y."/>
                <person name="Kufs J.E."/>
                <person name="Herboeck B."/>
                <person name="Guo H."/>
                <person name="Hillmann F."/>
                <person name="Beemelmanns C."/>
                <person name="Valiante V."/>
            </authorList>
            <dbReference type="PubMed" id="35023724"/>
            <dbReference type="DOI" id="10.1021/acschembio.1c00839"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">MFS-type transporter; part of the gene cluster that mediates the biosynthesis of sphingofungins, bioactive molecules acting as sphingolipid inhibitors via inhibiting serine palmitoyl transferase (SPT).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is not regulated by the sphingofungins biosynthesis cluster-specific transcription factor sphG.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Does not affect the production of sphingofungins.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="4">The sphingofungins A, B, C, and D, show a limited antifungal spectrum of activity but are especially effective against Cryptococcus species, fungal pathogens causing opportunistic infections in human.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZV4"/>
    <dbReference type="SMR" id="B0XZV4"/>
    <dbReference type="EnsemblFungi" id="EDP52286">
        <property type="protein sequence ID" value="EDP52286"/>
        <property type="gene ID" value="AFUB_034500"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034500"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="PhylomeDB" id="B0XZV4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000843">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF156">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000461280" description="MFS-type transporter sphD">
        <location>
            <begin position="1"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18404212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="35023724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="35023724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="579" mass="62101" checksum="E5E371925AEB1296" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0I7</accession>
    <name>B0Y0I7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_046340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_046340"/>
    <dbReference type="HOGENOM" id="CLU_008455_0_5_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0I7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP53457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="538" mass="59493" checksum="718941BE91D75829" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0R0</accession>
    <name>B0Y0R0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_058220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SHE9 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0R0"/>
    <dbReference type="SMR" id="B0Y0R0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058220"/>
    <dbReference type="HOGENOM" id="CLU_025632_2_0_1"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0R0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="350"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP51801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="502" mass="55938" checksum="E2A7A0863A7150C8" modified="2008-04-08" version="1">MQPMPLLLRQSLRSSANFARTSLPIRPQFLPAAGPNLQPAREIQRSFSVCVRCQFRSQSPLYSSPEKDTSKDDAATQQSKDGSSTLTPGDESAKVEPDAETQRPSPAAGEQDTLQGFYQDAKNEPKRESAEKKGLPSYLEERRSQLSKQFTEMMDNLQSNIFVAGQRLNDLTGYSAIEALKKDIQLQEERLREARQRVREAKNAYAAAINRRSASQREVNELLQRKHAWSAADLERFTHLYRNDHTNEVAEMETQEALSAAERESEEAAAQLSKSILSRYHEEQVWSDKIRRMSTWGTWGLMGVNVLLFLVFQIAVEPWRRKRLVKGFEEKVIEAIEKEKAINHIEILKPQPALTSTSPSSKEEAAEPTPTSTAAGDTPTTDESTPAATDETITSEPVVWDSDPIPTFVTNITAEIATETTEDSAPKSATINGVEPRKSQLSRILPPLPPPTSLDSWRHTLNELFSDRSMVITQRDLTTVALQSAAAGAAIMGLVIALIRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0R3</accession>
    <name>B0Y0R3_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_058250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0R3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058250"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0R3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000004">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="602"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="715"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="820"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP51804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="852" mass="94032" checksum="EEA800ECB880B251" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y130</accession>
    <name>B0Y130_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF985 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_059410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y130"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059410"/>
    <dbReference type="HOGENOM" id="CLU_097615_0_0_1"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="PhylomeDB" id="B0Y130"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="2">
        <location>
            <begin position="31"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="210" mass="23210" checksum="742DD76880D628F2" modified="2008-04-08" version="1">MDIPIPSIQPFYHPSPTSPKPIPESKSPSIQTILQTLHLQPHPEGGYYAETDRHPLAIPNPHNTDQNDTRSLSSSIYYHLNPDSPTCVFHLNRSRTIHALHRGRARYVIIHADSATDNGTAPVTSFVVGPDLDKGEKMQWVVEGGKYKACYLLPDDSSESGDGGSGGLLITETVVPGFAFEDHEFLSPQTMERLLPDEQCRALSWLLKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1K6</accession>
    <name>B0Y1K6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_049630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049630"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1K6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF39">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="559" mass="62498" checksum="15898724110C4373" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1L0</accession>
    <name>B0Y1L0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxypeptidase S1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_049670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP50966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1L0"/>
    <dbReference type="ESTHER" id="aspfu-q4wdz3">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.008"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_049670"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="PhylomeDB" id="B0Y1L0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000005">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758543" evidence="6">
        <location>
            <begin position="18"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="488" mass="54180" checksum="C28943E4893FBC0E" modified="2008-04-08" version="1">MWCQKWLFAFLVAGASAAPASTAKDSISSVVKNGVKYTVFEHAATGARMEFVKNSGICETTPGVNQYSGYLSVGDNMNMWFWFFEARNNPKQAPLAAWFNGGPGCSSMIGLFQENGPCHFVNGEDTPSLNKYSWNNYANMLYIDQPIGVGFSYGTNDVTSTETAAPYVWKLLQAFYAQFPEYESRDFGIFTELIFQSYGGHYGPEFASYIQEQNAAIKAGTVSGENINLVALGVNNGWTDSAIQEKAYIEYSYNNTYKQLINSSDRTRLLSVYNSQCLPAIQKCAKTGTNADCRNADSVCYSNIEGPISESGDFDVYDIRQPQNDPFPPQTYSTYLANPNVVKAIGARTKYQECPNGPYNKFSQTGDTDDVDPRSFLATLSDVVKSGINVIVWAGDADWICNWLGNYEVANAVDFPGQSRFTAKDLAPYTVNGVEKGTFKSVDNFSFLRVYEAGHEVPYYRESFLTSQPETALQVFQQILQKKPIFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y1W8</accession>
    <name>B0Y1W8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_050100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y1W8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_050100"/>
    <dbReference type="HOGENOM" id="CLU_2721749_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP51008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="72" mass="8362" checksum="D615ABE4CBBC28A1" modified="2008-04-08" version="1">MRFRSRAIDQFREHTQPQHLTYCDHGGPLNGVTAAITCLILVKWRRDRKLVMPVRSKYRISRPCLQPAARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2F4</accession>
    <name>B0Y2F4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_051260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2F4"/>
    <dbReference type="HOGENOM" id="CLU_010106_0_0_1"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2F4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000016">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="57"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="227"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="594"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="775"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP51124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="888" mass="101063" checksum="5C83AF3620E29876" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2R5</accession>
    <name>B0Y2R5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF4E3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_051690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y2R5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_051690"/>
    <dbReference type="HOGENOM" id="CLU_043552_0_0_1"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="PhylomeDB" id="B0Y2R5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="347" mass="37370" checksum="281AF169AD5E1398" modified="2008-04-08" version="1">MDNANLWTRRANSAKLSLSMTGTDGKDGGAKVDLPRGHTSKRFGPDSSHGGRSNPFNALSPLSGGVSSPSTNASSAFGLGSGAFASFGTPKTPGTNASDLNSSKALGEKRETASEQDSAADVKAKASASSLTGPKEHALKSTWVIWYRPPTPKYSDYEKSTIPLASISSVESFWSIYTHLKRPSLLPTVSDYHIFKKGIRPVWEDDANKKGGKWIVRLKKGVADRYWEDLLLAMIGDQFAEASDEVCGAVLSVRSGEDVLSVWTRIDGGRNIKIRETIKRLLAFPADTNIVWKSHDDSIAQRSAIDQARQEKAAGNAGHHHHHLAGDRRRPTANDESMGDKGKAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3W0</accession>
    <name>B0Y3W0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_055610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3W0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055610"/>
    <dbReference type="HOGENOM" id="CLU_1272020_0_0_1"/>
    <dbReference type="OrthoDB" id="4474044at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="217" mass="24061" checksum="D9D430D578326EA6" modified="2008-04-08" version="1">MADPIVDLASRPDSQFDDEEHLKPHTQEKQPKQEQLENGKQQHTASAPTPNPHNLLPNTFTISGEYEANNMNPIISSVLVVLFSILSFLDTYILPSHLRVMILETALTHPLLTTFFLCQFVCSCIPVIIFLIGATIAGGIAVVVFSCFALLVLGPVLVATTITGLFLWGWGWVTFVVGRWLLRQYLSEDGDGEKDRARESVNGFNQYEAAKVKEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y3W6</accession>
    <name>B0Y3W6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_055670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y3W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_055670"/>
    <dbReference type="HOGENOM" id="CLU_030582_1_0_1"/>
    <dbReference type="OrthoDB" id="5377009at2759"/>
    <dbReference type="PhylomeDB" id="B0Y3W6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="503" mass="55206" checksum="09E78841648B411C" modified="2008-04-08" version="1">MLQNCDHSSMPGSTAVATDNLEPTSIPTSSVAQDNRRQPDKDIPPSHDNAVDTLPNLSSQITDTLTPLPERNRLTSAHTPSHRRANTEIIRRQPHLSVKQLFADQPKTYEDLVDGDRSSSSALENSTRKTLEVGARLLSGWFQGKSEPVNLTMVPQSAHQDALGLAPSGAFLNRASKRASSPLKQVTSTNPFNFFAFKRQGEGRPQLPEPADDEILNMDITAALFPPESLDLDGQEAFSALRTNADNLLRRLQAAYKERTFALHEALADKNEKQEELEETRTRVGHLKVQLDGMAEKVLQQEKAMKAMAEELEQERQLRRREDDARRRSVMLVRSSDEESLSDVGAELQTPKRSLKRASNGTYTSDSGFDSGDESLAESIFSRRDGLESPTSTIPPSPNISQIALSVPTSTPIQPSAKELKPAQAPPVRQSTYDRVLKGLASTGITSSWMGHTSTSKCNICHGIPASEAWGVLGVIKEENRGLKLRLSELELVVDDCLSLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y440</accession>
    <name>B0Y440_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AFUB_056420</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y440"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056420"/>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="PhylomeDB" id="B0Y440"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000016">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="100"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="584"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP51631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="777" mass="83745" checksum="03D6C49115AF60D5" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y449</accession>
    <name>B0Y449_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_056510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y449"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_056510"/>
    <dbReference type="HOGENOM" id="CLU_031804_1_0_1"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="PhylomeDB" id="B0Y449"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122560" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="308"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP51640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="462" mass="51643" checksum="B5F6ADFBB9F61E02" modified="2008-04-08" version="1">MRWCLTLLAFCFLAVVRALSSSGSRLLVVLEDATEKELYSKLWADLEARGYNLDFESPKNDKLSLFELGDRVYDHMLLLPPKSKGYGPSLTPKNIIDFMNKDGNVLLALSGKSTTASAISSLLLELDLHLPVDRSSVTVDHFNYDTLSASDKHDVLLLHRPGKLRSDTKAFFDGEGVVAFPRAVPHTLGDANPLIAPILRAPATAYSYNPKEDASSVEDVAATGSQLALVSAMQARNSARFTLLGSVESLQDQWFSATVKAPGDGKQMKTVNQEFAKQLTAWTFKETGVLKVGKIEHHLAEDGEITPEKLNPKIYRIKNETVFSIELSEYNYDRYAPFEVPTGDAVQLEFTMLSPFHRLNLEPVRRTDNSTVYSTRFTTPDQHGIFSFRVNYKRPFLTNIEEKLEVTVRHFAHNEYPRSWKISGGWVWIAGLWSVIAGFLVFVVAWLYSAPSAAALNTKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4C4</accession>
    <name>B0Y4C4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_057260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057260"/>
    <dbReference type="HOGENOM" id="CLU_000454_0_0_1"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4C4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1915"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1347"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1470"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2058"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1351"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1474"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1488"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2074"/>
            <end position="2083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP51715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2120" mass="235022" checksum="E79FE639515B2C09" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4F7</accession>
    <name>B0Y4F7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Formamidopyrimidine-DNA glycosylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_068930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068930"/>
    <dbReference type="HOGENOM" id="CLU_038423_0_1_1"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4F7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.190.10:FF:000004">
        <property type="entry name" value="Putative Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP50556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="367" mass="41846" checksum="D178858E6C3BB015" modified="2008-04-08" version="1">MPELAEVSRIVHFINQHLVGKTLTKVSAQNDDIVYGKVGTSASEFQKAMEGKKVVSAGQQGKYFWLIMNEPPHAVMHFGMAGWLKIRDADTYYYRVEKPEDKTWPPKYWKFLLETDGDPKTEAAFVDFRRLSRIRLVDCPGEEIRKHSPLKENGPDPVADKDIVTEEWLADKLKSRKVPIKALLLDQANISGIGNWMGDEILYHAKIHPEQYSNTLNDEQIKQLHSSIHYICTTSVDVLADSEKFPEHWLFKHRWGKGKKNKPPVLPNGEKIVFLTVGGRTSAVVPSVQRKTGPVARDIDDEDTNGPKTETKRKRVTAVTKEEDVNDDEKEPKSKKHGSRSGQSEDTVEIKEEPKQEGRRRSTRLRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4J4</accession>
    <name>S2538_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_069300</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4J4"/>
    <dbReference type="SMR" id="B0Y4J4"/>
    <dbReference type="EnsemblFungi" id="EDP50593">
        <property type="protein sequence ID" value="EDP50593"/>
        <property type="gene ID" value="AFUB_069300"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_069300"/>
    <dbReference type="HOGENOM" id="CLU_015166_0_3_1"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4J4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000378925" description="Mitochondrial glycine transporter">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="2">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="2">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="2">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar 1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar 2" evidence="2">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar 3" evidence="2">
        <location>
            <begin position="223"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q96DW6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <sequence length="320" mass="34454" checksum="7C371980A787B1A7" modified="2008-04-08" version="1">MLYSCLASKTTFHFAAGLCSGLTSSILLQPADLLKTRVQQSQKTASLLPTIKTILSSPHPIRGLWRGTLPSALRTGFGSALYFTSLNALRQGLAQTEAAMAIAASSSDGKSRTSSSALPKLSNWGNLATGAVARTAAGFVMMPVTVLKVRYESDYYAYRSLYSAGRDIVRTEGVRGLFSGFGATAARDAPYAGLYVLFYEQLKRRLALVASSEQSEQPLKSTSSSSINFVSGGLAAGLATAITNPFDAVKTRLQLMPGKYGNMIRAVRLMIREDGVRSLFGGLGLRITRKALSSALAWTVYEELILRAEARWAEKDKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y4W9</accession>
    <name>B0Y4W9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WSC domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_070580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y4W9"/>
    <dbReference type="HOGENOM" id="CLU_024893_0_0_1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="PhylomeDB" id="B0Y4W9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760438" evidence="3">
        <location>
            <begin position="27"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="293" mass="30852" checksum="E29F520AB2F758A7" modified="2008-04-08" version="1">MKPFTARSAFTASVLLLTTNLPAVFAAEMVSQGCFSDSTPLVDQGPYTYQSNGYCQQLCMKTSNNLVFALTKGSNCLCGNQLPAKSAKTADSDCNVKCAGWPDVMCGGQNTFSVYLTGLSSNVAYYHDDDASTSANANSSSTSTTNGGSTVTTGSQGQVVTQGEQTVVVTAPAGNGVGATNGLNEEKNKDGPNTAAIAAGVVVGVVGFCSLVGAGFFLWRFRKRTNVRPQYSNNAGATEHFGKPMSQDSMSDSRFDGDFMAQRRQSNGSIDDDQDFSRRILQVRLFSSALGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5B7</accession>
    <name>B0Y5B7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_072060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5B7"/>
    <dbReference type="SMR" id="B0Y5B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_072060"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5B7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000934">
        <property type="entry name" value="Short chain dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP50866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="257" mass="27460" checksum="F39D2928B994A82C" modified="2008-04-08" version="1">MNTAIITGAAQGVGLCIAEALAQRNYRIVLSDIDTEKGPAAASKLNLTHGEGTAAFFHCDLSNLREIDALLSFTIETMGGFSVLINNAGYLRAPFLALSAQDIQDMITVNLTAPIYATQQAIKYWDGLHQGQAGCVVSVTSSSSFKTYASIAPYGAAKAGAAMFTFAAGAFHPRVRVNAVAPTAIATGFDKNRMRVETDRTGPGYTPEEEMRAMGLKRLQPQEVAEAVVRCVEDKGLYGKVLYLDAVEGIKIHDGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5Q8</accession>
    <name>B0Y5Q8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP dependent RNA helicase (Dob1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_064250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5Q8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064250"/>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5Q8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="169"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="405"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP50093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1082" mass="122648" checksum="EDE5CB3B500A9269" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5R7</accession>
    <name>RT25_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_064340</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5R7"/>
    <dbReference type="SMR" id="B0Y5R7"/>
    <dbReference type="EnsemblFungi" id="EDP50102">
        <property type="protein sequence ID" value="EDP50102"/>
        <property type="gene ID" value="AFUB_064340"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064340"/>
    <dbReference type="HOGENOM" id="CLU_081350_0_0_1"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5R7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029764">
        <property type="entry name" value="RSM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000343541" description="Small ribosomal subunit protein mS23">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="258" mass="29752" checksum="5B544E63F75F0B05" modified="2008-04-08" version="1">MGKYNFTALRVRQTALRQHAAGKIRAPPKWLDVVADIPPAQVLVRNQAPQHQLVRQRVKTLPGTSKPQVVFEVQEKRIKPKKASRMFLPTEIKYEEDQLRQEFFRDHPWELARPRVLVESTGKDSEHYDWSRLQQPGKRLDGESVVQRQLWLLNNVPDMTKSAAYDIARREFYRLRLQEDIERRVAAEEAEATGATFGPSLLEVGMELENQEYERWKAWAKMEAQLLDQKTAAFTGAPEIAAADDAVEELEEKVPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y5W6</accession>
    <name>B0Y5W6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_064830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y5W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_064830"/>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="PhylomeDB" id="B0Y5W6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="176" mass="20113" checksum="8A190DF65F62529B" modified="2008-04-08" version="1">MQSDGKDKSANPMRELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRKKNFSETGNFGFGISEHIDLGIKYDPGIGIYGMDFYCCMTRPGERVAKRRRCKSRIGSSHKITQAETIKWFKNRFDGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6A1</accession>
    <name>B0Y6A1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_066190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AFUB_066190"/>
    <dbReference type="HOGENOM" id="CLU_072377_0_0_1"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6A1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="7">
        <location>
            <begin position="133"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP50286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="333" mass="36521" checksum="033F0B4CEDF6CE9D" modified="2008-04-08" version="1">MSGLVHISSKEQFSTLLSTSKFVVADFYADWCGPCKAIAPAYEQLAKQLSRPNRITFTKVNVDQQQDIARAYGITAMPTFIVFQQGRPISTVRGADPKALSDAVRKLADEANKNDNSASGEASGDLSGGNGWIGAAVPKGYSDITDQHDPKGLELLNWDSDFGTAKTLFDPSKPSALSNNGKRKEGAPADWVESDTDEQLMLFIPFQSTLKVHSLQVTSLASPSEDDDEAPMRPKTIQLYTNRSHVLGFDEADDITPVQTVTIQPEDWDPKTATAKIDLRFVKFQNVTSLVLFFVDGDGDSEKLRVDRIRIFGEAGEKREMGKLEKIGDEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y6R8</accession>
    <name>B0Y6R8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF2 family helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_067910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y6R8"/>
    <dbReference type="HOGENOM" id="CLU_003233_2_0_1"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="PhylomeDB" id="B0Y6R8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="893"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1139"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP50453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1180" mass="133064" checksum="68C492E5D73990BD" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y701</accession>
    <name>B0Y701_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_068730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y701"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068730"/>
    <dbReference type="HOGENOM" id="CLU_030880_3_0_1"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="PhylomeDB" id="B0Y701"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP50536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="613" mass="67096" checksum="DE15DA35DCD24727" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y707</accession>
    <name>B0Y707_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_068790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499598">
        <property type="protein sequence ID" value="EDP50542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y707"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_068790"/>
    <dbReference type="HOGENOM" id="CLU_008455_0_1_1"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="PhylomeDB" id="B0Y707"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000475">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP50542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="494" mass="54958" checksum="EFC3200E1BCA92A8" modified="2008-04-08" version="1">MQTKIATADEKLSPLSRPDSLQFHLSQYGLKMTTDELYVQWEIGNRRHPRNWDVSRKVYDISLIFFLEFFTLEKTKSIFIFVSVYLLGQALGGILFPPYSEAFGRKKLYIISTALYSISCLVVAAVPSLSGATVGRFVSGFLSAIPTTVVIGSIEDMFNARDRVWMVCIWAITSNLGLIVGPILSIYVVADLDWRWLFYIAAIVTGLLTFLLLTIRESRPSLLLAREVAQLRKASKVESLEGVNPDHTPDLHSFVRLALSRPVLLFFTEPIVFIVSMISAISIALVYLFTEALPPIYESFGFSPRQASLPFVAIGVGLSLGLLTRFFDLYIIDQHRQQGRVLLPEHKLLGLWLGTPILAGGLWVFAWTIPPGVKDLHWSVSVIALLLVGYSLTELDYVLGGYLTDSYLSYASSGFSALSFLRSILSAVFPLVSPHLFSALGANLAVTVLAAMATIFCIVPPLFTRYGEKLRARSAFAKQSLTTYRQYSVDENGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7D8</accession>
    <name>B0Y7D8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_073460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7D8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073460"/>
    <dbReference type="HOGENOM" id="CLU_002615_1_0_1"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7D8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="828"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP49319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1160" mass="126564" checksum="163D20049760ACB3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7E6</accession>
    <name>B0Y7E6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_073540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7E6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_073540"/>
    <dbReference type="HOGENOM" id="CLU_005559_2_0_1"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7E6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="809"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="748"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="918" mass="102315" checksum="0D76B141DDA2F594" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y7W2</accession>
    <name>EXGD_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable glucan 1,3-beta-glucosidase D</fullName>
            <ecNumber>3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">exgD</name>
        <name type="ORF">AFUB_075220</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y7W2"/>
    <dbReference type="SMR" id="B0Y7W2"/>
    <dbReference type="GlyCosmos" id="B0Y7W2">
        <property type="glycosylation" value="10 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP49493">
        <property type="protein sequence ID" value="EDP49493"/>
        <property type="gene ID" value="AFUB_075220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_075220"/>
    <dbReference type="HOGENOM" id="CLU_004624_4_0_1"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="PhylomeDB" id="B0Y7W2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000395162" description="Probable glucan 1,3-beta-glucosidase D">
        <location>
            <begin position="1"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="4">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="4">
        <location>
            <begin position="327"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="680"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O85465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P29717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q5AVZ7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="833" mass="94775" checksum="6A08231B6A8A1855" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8C6</accession>
    <name>B0Y8C6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_076870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076870"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8C6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP49657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="329" mass="37689" checksum="CE805FDD441A3AD1" modified="2008-04-08" version="1">MENNMEIDPARSPEPHHLSPTTDPGSIPTLDGWIENLMACKQLAEDDVRRLCDRAREVLQEESNVQPVKCPVTVCGDIHGQFHDLMELFRIGGPNPDTNYLFMGDYVDRGYYSVETVTLLVCLKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALIENQIFCLHGGLSPSIDTLDNIRSLDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8D8</accession>
    <name>B0Y8D8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Apoptosis-inducing TAF9-like domain 1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_076990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8D8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_076990"/>
    <dbReference type="HOGENOM" id="CLU_100369_3_0_1"/>
    <dbReference type="OrthoDB" id="1872155at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8D8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP49669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12605" checksum="3CC94784FC980108" modified="2008-04-08" version="1">MDPNEEVSLEERLKSALWLSIGKIVDEETIKLGVNATPQFIGALTEMVWTQIETVSQDLEFFAKLTRCLRRRHAGRSTINVSDVMLLARRNEGLESILRAFVDQQREEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8E0</accession>
    <name>B0Y8E0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_077010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077010"/>
    <dbReference type="HOGENOM" id="CLU_002893_1_1_1"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8E0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000678">
        <property type="entry name" value="Putative UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000592">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000629">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000006">
        <property type="entry name" value="UV-damaged DNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="12"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="425"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="783"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP49671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1140" mass="124900" checksum="CEB7A1BC11DD11C9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8L1</accession>
    <name>B0Y8L1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_077720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8L1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_077720"/>
    <dbReference type="HOGENOM" id="CLU_038296_0_0_1"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8L1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758282" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP49742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="370" mass="39212" checksum="7887FA976D5E3536" modified="2008-04-08" version="1">MRSFISLLAFPASSLAGSVLWSGIFDSSATVEDFDKWSWSNQVGSWQWYIHGSGKTSEYLGLSPDFKNPADTSDAQGVRITIDGTSFWNGQNMERSELIPQTTANLGSGHLYYHFSLSTKTTNAPDASFEHQIAFFESHFTELKYGASGSSDNTLRWYANGQTHWSIQLEPGNWYNFAYDIDFASQKVGLWASNGSDPLTEVVSPVSASTSTNSADWHVGQLRLPNGGASNDAPEDWFWSGIYVEQAPITKEIGSPASSSSSSSSGSSSSTPSTVSSASNPPASTSSSPQATPQPSSTPSTEPTATPASQAVTTPAASAPATNVATPAESSPQLPTPTTAAQLLADLRAALSALLSRSNSVHARDFARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8W6</accession>
    <name>B0Y8W6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase (UroS), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_078800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_078800"/>
    <dbReference type="HOGENOM" id="CLU_051874_0_0_1"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8W6"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="341" mass="36702" checksum="D67C261499C7C976" modified="2008-04-08" version="1">MTTSPSYAFSSSSATPILLLKTKSTPHDGYEEFFSAHGYNPAFVPVLEHHFHQTNLHTVKDLFTSGSLNAGPRRKYGGLIFTSQRAVEGFARLVTSEVDATAASHSLILYTVGPATSRSLTTLRDSHLPHATIYGSDAGDGQKLALAILEHYNALYDSGGVDASTGAPPVKPPLLFLVGEQRRDIIPRTLMDESLSPAKRIQVDELVVYETGVMESFRGDFQAAVRAGQEYLALAGQDRDADGKNVAIWVVVFSPTGCDAMLRVLGLLSTSTEPSAGGADTLVDGSASRTERRFFIATIGPTTRDHLVKNYGFQPDVCAEKPSPEGVGAGIEAFLRRWKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y8Z8</accession>
    <name>B0Y8Z8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Arsenite efflux transporter (ArsB), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_079120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y8Z8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079120"/>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_1"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="PhylomeDB" id="B0Y8Z8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP49879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="382" mass="41520" checksum="8CF04938FCC7AFEF" modified="2008-04-08" version="1">MSQARLGSIPDIAKPSPAQAADMEKQGEPSLPDGPPGKQSAFKNLGILDRFLALWIFLAMAIGIILGNFVPNTGPALQKGKFVGVSVPIAIGLLVMMYPILCKVRYEGLHHVFRTRQIWIQIAFSIFVNWIIAPFFMLALAWAFLPDEPELRQGLILVGLARCIAMVLIWTGLAGGDGEYCAILVAVNSILQMVLFAPMGVFFIQVISGDSVAFEYSTAAKSVAVFLGIPLGAAILTRFTLRWVASPKWYDEVFLKWASPWSLIGLLFTILVLFASQGRQVVHQIVSVVRVAAPLIVYFTVVFFVTLFISYKMGFGYKLSATQSFTAASNNFELAIAVAVATFGANSNQALASTVGPLIEVPVLLGLVYAVKALAKRLAWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y943</accession>
    <name>B0Y943_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_079580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499599">
        <property type="protein sequence ID" value="EDP49924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y943"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_079580"/>
    <dbReference type="HOGENOM" id="CLU_038125_2_0_1"/>
    <dbReference type="OrthoDB" id="5280547at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760779" description="Alginate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44929" checksum="3AB58DB066B09EA1" modified="2008-04-08" version="1">MWKIFLNILALAGVCHSIVSDIPSVYGPIPHVGDFSGVDSTKYLKRRPGDFVHPGIWHTHEDLERIRTNVISKKDPWASAYEKFSADEYSQANYQMQGPHAVISRGKISNYTSFAHDVRAAWQNALMWYITRNQSHWDRSTTILDAWGSNLTDIIGTDRSLLIGLDGDLFVNAAEIMRWEGNWTEAGAKWQGGSGFSNQLYWLFSRQSVVVGQANYGMASIKAMLSFAVYLNDVELYNYAMNAFIQDNCAGLFAQYHPETGQSVEAGRDQSHTMSGIGWAAYGARVGQSQGVDLYSLGHNLLLKASEYAAKYNLNETVEYDPKWSRCEAVLVNGPWATISEQRRGVTNQNPIWDILYYQYVVKRKAKAPWTTKAREFEGFEGAVSSNDHPSWGGLIWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y997</accession>
    <name>B0Y997_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_080250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y997"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_080250"/>
    <dbReference type="HOGENOM" id="CLU_1721917_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="152" mass="16272" checksum="9403BA540E55BA99" modified="2008-04-08" version="1">MCITSKDTSISRTPEACSHYLHELRPPRESEIATYLNGGASNAGIQPSQFANPAPLKHDGSLFLPTEVVPMDLSDGHPGGSNTQNLHGSPMDHGSAPLDRANHSSPTMATEKASPGFASIANIITPTRNTESFTPINDERRLPVFIKRLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9L1</accession>
    <name>B0Y9L1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_081420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9L1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_081420"/>
    <dbReference type="HOGENOM" id="CLU_1022989_0_0_1"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758325" evidence="1">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="272" mass="30104" checksum="A817BE517297A4D2" modified="2008-04-08" version="1">MRSFLLAVLGLMATSSLAAPGQAAREGISAFEAIGNLKSGDHVYVHIADDGVARAYDENESVIDYIPLTNDQLKQLLRNLPEPWKKEEDHLHAVFNGVDGRDVMDEKQLLDPPAELRNPMPPLSNRPTGIAEANPALETQLADLWAAHIVRGWMLSFQGERVSAFSGSILSKDEEASKAIPSLKQSPSLKGLNHLATDGVYRSFSSSGQVVDYKQLSPADITKVLEFHEKYMDSEIFQKTKKKFDGVDGRNVTDLEQLLHPGPESRPVRFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9V7</accession>
    <name>B0Y9V7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_082420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082420"/>
    <dbReference type="HOGENOM" id="CLU_2385740_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="94" mass="10321" checksum="B217AAF1896B1842" modified="2008-04-08" version="1">MDRVVAVGREKSHFGQQNESSISNVTKTVRNGGVHPENPQKNYPLWDLGKKKSKTRGYPMSVCDTNSRLAESCKIIAVSISKHQCGDAPSVTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9W8</accession>
    <name>B0Y9W8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nineteen complex-related protein 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_082530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9W8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082530"/>
    <dbReference type="HOGENOM" id="CLU_031138_1_0_1"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9W8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP48811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42912" checksum="B48F685CA17F1247" modified="2008-04-08" version="1">MPDNGPVVKRPNPLKSKQKSKLRLSFGPGETSMTDDGGQESEVVLPKRHGLGRRALEKSALQRAGKPPGLGDQLPIRVPEQERPSYSEDYLKELRNSTPSTPKAATDDERDKTVDVAAKFGEVMKVSAPSAIPSEAEIREKKARRARLAKELASGTEEQDFISLEENMSDEEWGLKKTEKEDMRDTRLIRDDEDFAEGFDEYVEDGRISLGKKAEREQKMKQREQMRELIEEAEAISDEDDSDLEEKAAYEAAQTRAAIGSDGRDHINRPRTPPKITSLPRLSTSLERLRTMLAVLEKSRTQMINRMEDLRKEKADIAVREVEIQALIKEAGDNYERLRQEAGLTPGSEEDLSIATDIKNARGLESFGASIAGSAGDSGSQSPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y9Y5</accession>
    <name>B0Y9Y5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_082710</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP48828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y9Y5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_082710"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="PhylomeDB" id="B0Y9Y5"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
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        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
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        <property type="entry name" value="PRK05729.1"/>
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    </dbReference>
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        <property type="entry name" value="valS"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
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    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="108"/>
            <end position="729"/>
        </location>
    </feature>
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        <location>
            <begin position="774"/>
            <end position="922"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="985"/>
            <end position="1057"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="72"/>
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        </location>
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            <end position="94"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119978" checksum="DA06C5E2FF91EF95" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAJ8</accession>
    <name>B0YAJ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_084910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_084910"/>
    <dbReference type="HOGENOM" id="CLU_2605586_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP49041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="79" mass="8818" checksum="04C33E815BC94AD8" modified="2008-04-08" version="1">MSQRHQPMEMADAPIPSHHAIIHPRKIFSASIIGFDLMATPGHVLNVMECAANSCRTSQKLGGWSCDAIQGRRLRHRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAM3</accession>
    <name>B0YAM3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_085160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085160"/>
    <dbReference type="HOGENOM" id="CLU_004495_6_2_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="PhylomeDB" id="B0YAM3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP49066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="455" mass="49265" checksum="7D5C6928086CDD9B" modified="2008-04-08" version="1">MAVVLMATWEALSRWVVAATPHTMVSALVSGGPVSLVYGFILALIGALATAASLGEMASMYPTAGGQYHFIAKLAPEQCRYMISWLVGWIGTFGWVAFTASAPFLAATMIQGLVVLNYEEYQAKRWHGTLIYWALLAISAVVNIWGARLISLIENASSLIHLAAFVAEFVVIWVCAPTKHSASFVFTLFRNESGWSSNGVAWSIGYDGAIHLSEEMTNAEVAVPWCMLGSLAINGMLGFAFLLTVLFCMGDFEAALNTATGFPIIQIFYSITGSAAGSAAMTSMLIIMAGLATIPLTASTARMLWSLTRDRAFPFSTYLSIIDKKTSLPVRSVFTTSGFLVLLGLINIGSTTAFNAILSLAVLGLHMSYLIPTGFMLWRRLHTPEILAYGPWKLGKNGCRSEHCFHPVSVLHLHLHGLSPVPAGVCRQHELCLADFWWSAYCKLDILAVEGTKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAR0</accession>
    <name>B0YAR0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_085520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_085520"/>
    <dbReference type="HOGENOM" id="CLU_760706_0_0_1"/>
    <dbReference type="OrthoDB" id="4672515at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760562" evidence="1">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP49103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="364" mass="40330" checksum="E5051B68D23D893A" modified="2008-04-08" version="1">MRVTVFSLLTALSASLVCAQGYSKDCSDIYLQEGWLVATCPKDDNNGRITSSVYLPNKIANDNAVLEEHIANYDGHLLSNLAGAVTHVPEDSSYPIPSEFEVELDVSTLNNSCASYGGTIKLTRPTSCWYLNVGVEYSWACGNSKNNQGWEIVGYSDKDCTSDPVAAFTQENQGTCLTFSTGVKGFSSTNAPDLATAVSHHIRRPASMREVGEMWKNILVGFFPNREYAPFPFRDTHYYINLDLNTHGYLGLGSVVRTQGFNAGVHFLQLNFTAAPADGSPFSWEGNEHFLKREMRGSLQSVPEDRKRAIYGLIAIGTYVRLYRYLPDGQFAPVTFVVGKQTLHVRADQAVIREFLAGVQEEWM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B0YAX5</accession>
    <name>MAP23_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine aminopeptidase 2-3</fullName>
            <shortName evidence="1">MAP 2-3</shortName>
            <shortName evidence="1">MetAP 2-3</shortName>
            <ecNumber evidence="1">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AFUB_086160</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP49168" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="1"/>
    <dbReference type="EMBL" id="DS499600">
        <property type="protein sequence ID" value="EDP49168.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YAX5"/>
    <dbReference type="SMR" id="B0YAX5"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000407621" description="Methionine aminopeptidase 2-3">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="446" mass="48996" checksum="69A91BEE68E78371" modified="2011-05-03" version="2">MTVDAPELLEKLRITDAGANGADMSSSTSAAANGTGKEVDDGSDDDGTENPPAVAAEHSTAKKKKNKKRKPKKKQPKVQTDPPSIPLSQLFPNNSYPKGEEVEYKDENRYRTTSEEKRHLDNLNSDFLSDYRQAAEAHRQVRQWAQRNIKPGQTLLEIANGIEESARCLVGHDGLTEGDSLIAGMGFPTGLNIDNIVAHYSPNAGCKTVLAQNNVLKVDIGIHVGGRIVDSAFTMAFDPMYDNLLAAVKDATNTGVREAGIDVRVGELGGYIQEAMESYECEIRGKTYPIKAIRNLCGHTILPYSIHGTKNVPFVKSNDMTKMEEGDVFAIETFGSTGSGRYVEGGEVSHYALRGDADRKDLTLSSARSLLTAIKKNFSTIPFCRRYLDRIGQEKYLLGLNYLVKSGIVEDYPPLNEKPGTYTAQFEHTILLRPTVKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBG4</accession>
    <name>B0YBG4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_092720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_092720"/>
    <dbReference type="HOGENOM" id="CLU_159430_0_0_1"/>
    <dbReference type="OrthoDB" id="4491142at2759"/>
    <dbReference type="PhylomeDB" id="B0YBG4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP48554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="103" mass="12312" checksum="C51D64738E8D6309" modified="2008-04-08" version="1">MAKPRKIRHRQSNKPKAKHQQHKRRGDTLFRKAFEYCQECNADVSLVVRLKDNGQIYIFNSDNRWFPSEEGLEILDYTNRHKTLHYPVPLRITWQELAAAYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBV4</accession>
    <name>B0YBV4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_087950</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_087950"/>
    <dbReference type="HOGENOM" id="CLU_115512_0_1_1"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="PhylomeDB" id="B0YBV4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP48085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="105" mass="12033" checksum="81FFC2DEC2137F85" modified="2008-04-08" version="1">MKVTIKEWNAVATWRWDMPEDDVCGICRVQFDGTCPTCKFPGDDCSLLLGKCGHSFHMHCLMTWIQQESSKGLCPMCRQSMYTAAPVLDVMLMNCTEFEWKQNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0YBX5</accession>
    <name>B0YBX5_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="5">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cnxG</name>
        <name evidence="6" type="ORF">AFUB_088160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YBX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088160"/>
    <dbReference type="HOGENOM" id="CLU_114601_6_1_1"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="PhylomeDB" id="B0YBX5"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP48106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="91" mass="9837" checksum="B00F7AA2C6209760" modified="2008-04-08" version="1">MTSKETQPVFQIHYFSSASSYTNKATETLPAPLPLSRLFDFLEERYPGIREKVLVSCGVSLGEEYVDVEADGEVVIGAGDEVAIIPPVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0YC48</accession>
    <name>B0YC48_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-PSP endoribonuclease family protein (Hmf1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_088910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499601">
        <property type="protein sequence ID" value="EDP48179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YC48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_088910"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="PhylomeDB" id="B0YC48"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP48179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="168" mass="18016" checksum="AE12677251E0D883" modified="2008-04-08" version="1">MLKSSFRLLSSSSSRLLTSSPRFSAHYPVLRTYPTPFHRQSVNMSGMTPVFTTGACPPAGPYSQAIRANGQLFISGQIPADASGNLVEGNIGEKTQACCNNIKAILDAAGSSVDKIVKVNVFLTNMADFAEMNATYEKFFTHKPARSCVAVAQLPKGVPVEIECIALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0YD22</accession>
    <name>B0YD22_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphoethanolamine N-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_094000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YD22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_094000"/>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="PhylomeDB" id="B0YD22"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000058">
        <property type="entry name" value="Phosphoethanolamine N-methyltransferase, putative (AFU_orthologue AFUA_6G04290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="933"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP47556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1056" mass="114952" checksum="332D85ED328311C6" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0YDP0</accession>
    <name>B0YDP0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_096260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499602">
        <property type="protein sequence ID" value="EDP47774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YDP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_096260"/>
    <dbReference type="HOGENOM" id="CLU_1712837_0_0_1"/>
    <dbReference type="OrthoDB" id="5350396at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP47774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="153" mass="17535" checksum="9CF9486172FCFF19" modified="2008-04-08" version="1">MSDLKMIINLLKDRRFNINLYKGRGNPDAVTDLLNVAIDSGWSGLAFPTKEAEKDFNADVDRLSDRVKKIFVSIQDSGASHLKRTLAKEALETLHYRIIYSVRSKPPPKKTLLGHYGTEDGRAKYNLKQWIEARSREDKKDTQMPIRSHEHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B0YER7</accession>
    <name>B0YER7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">AFUB_100130</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0YER7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100130"/>
    <dbReference type="HOGENOM" id="CLU_000960_1_1_1"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="PhylomeDB" id="B0YER7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034638">
        <property type="term" value="P:phosphatidylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071071">
        <property type="term" value="P:regulation of phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000013">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="689"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="840"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="19">
        <location>
            <begin position="1219"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1501"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="1223"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="1250"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="1370"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="1252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP47411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1522" mass="168262" checksum="4EB5CC71B03724B3" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B0YEU5</accession>
    <name>B0YEU5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_100410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499603">
        <property type="protein sequence ID" value="EDP47439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YEU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_100410"/>
    <dbReference type="HOGENOM" id="CLU_2037530_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP47439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="121" mass="13778" checksum="16E4975078CED715" modified="2008-04-08" version="1">MSGMIISMPPGYRLSSRISGDIALISCLTKSLRDPHQHDENKIMSRTTRSMQARIGMSISSQWPERSAYWRGDEGFSVHHLTLAWMITEADMHDACRQDGSEAEKVEDVLLQRVQLPELVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B0YF71</accession>
    <name>B0YF71_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_101770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499604">
        <property type="protein sequence ID" value="EDP47184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0YF71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_101770"/>
    <dbReference type="HOGENOM" id="CLU_015092_2_0_1"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="PhylomeDB" id="B0YF71"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP47184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="567" mass="62839" checksum="E9EE6A9FC893E2AE" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM45</accession>
    <name>B0XM45_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase activating protein (Evi5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_000880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000880"/>
    <dbReference type="HOGENOM" id="CLU_005062_1_0_1"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="PhylomeDB" id="B0XM45"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="234"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="739"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="847"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="694"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="901" mass="100803" checksum="0968204534EF0B25" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM62</accession>
    <name>B0XM62_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_001020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_001020"/>
    <dbReference type="HOGENOM" id="CLU_002846_2_0_1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="PhylomeDB" id="B0XM62"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002759956" description="chitinase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="361"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="504"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="982"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP55411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1378" mass="146179" checksum="C197D26CB0E25C85" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XM94</accession>
    <name>BGLH_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-glucosidase H</fullName>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-D-glucoside glucohydrolase H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiase H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Gentiobiase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bglH</name>
        <name type="ORF">AFUB_000280</name>
    </gene>
    <organism>
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XM94"/>
    <dbReference type="SMR" id="B0XM94"/>
    <dbReference type="GlyCosmos" id="B0XM94">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EDP55338">
        <property type="protein sequence ID" value="EDP55338"/>
        <property type="gene ID" value="AFUB_000280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_000280"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="PhylomeDB" id="B0XM94"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000155">
        <property type="entry name" value="Probable beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF17">
        <property type="entry name" value="BETA-GLUCOSIDASE H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000394877" description="Probable beta-glucosidase H">
        <location>
            <begin position="1"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="389"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="664"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="829" mass="91020" checksum="9E62CDC1659A8EC8" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0XMR3</accession>
    <name>B0XMR3_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AFUB_013880</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0XMR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_013880"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="PhylomeDB" id="B0XMR3"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005285">
        <property type="entry name" value="Drug-R_PDR/CDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00956">
        <property type="entry name" value="3a01205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1224"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1267"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1314"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1348"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1465"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="158"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="853"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP56670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1497" mass="168184" checksum="706E5D1B5C097043" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNJ8</accession>
    <name>B0XNJ8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved glutamic acid-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_015400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_015400"/>
    <dbReference type="HOGENOM" id="CLU_344548_0_0_1"/>
    <dbReference type="OrthoDB" id="5339076at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="874" mass="96298" checksum="290780FD6760E2FC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XNN7</accession>
    <name>B0XNN7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator Npr2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_004930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XNN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_004930"/>
    <dbReference type="HOGENOM" id="CLU_014995_3_2_1"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="PhylomeDB" id="B0XNN7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="587" mass="65355" checksum="782B637993602E4E" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP45</accession>
    <name>B0XP45_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PXA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_005880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_018250_0_0_1"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="PhylomeDB" id="B0XP45"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="101"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP55888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="444" mass="49426" checksum="68196A6B6842AD3C" modified="2008-04-08" version="1">MTSESVQPGLTPLSHLKAVPTTSSSKPLAFKDSSVLQATPQLRHRSRLSKNVNRDEPVSATSDKATVALIRRVLCSQAGNQSGGASTPQPLEELLPPLTSSNEVDLQLYALIAIIIKEFVLSWYSKITSDQNLVKEVIQVIAHCTRALEQRLRETDIAQLIFDEIPGLIEAHIISYRLARDESTLSGLSPSVRETYHALHPHPSLSPIPDSSDMRTIEKQRENEAIYRQLLAHGMLAILLPTEDLENVPLRTIIGDILADLILGNAVSEKMCQGWFLWETTTKLLSTAERLDEHEEDTADSHQQDRLHKFGLLTVNDDPKSDQSSSQTQSFGQAWLWNILQYLYLTYIVLQFIVTGLFRVMTNAKANVSSAAITPEISETEKSAPMGGTSTKRPILNYRIYSMVLQMLDIPRRMPWLAGFLSLFQYLTLAGPGKLGETGSVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B0XP58</accession>
    <name>B0XP58_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_006029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XP58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006029"/>
    <dbReference type="HOGENOM" id="CLU_023134_0_0_1"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="PhylomeDB" id="B0XP58"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP55901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="356" mass="40036" checksum="6DA1D29202AA9B65" modified="2008-04-08" version="1">MQAFVPKNRRIFAQIIDLNNVPLVSGTAFVKWRLPSSSTAEHHGHTDKAIILDHRAYWNYEKTLQVRLTIDRNQTLHECELVLDIIQEFGSGGHSDKNFLGRIRLNLAEYVDKSDDEEGIVRRYLMQDSKVNSTLRVGIVMHQIDGDRNFITYALLSLIIISLVLIASSPPLRSAAVFAGIAGVVSSEQADHDELGRLPSINTQSREVADMQDMYRRTLAASWLSGTDDIPADKLIEDLFATGSCGNDEHPDARSRRTADNNNELHPDRDTDTRQTRSGNRLSPSFERRPKSSSSQFLNESKGSDSSGHIRKGGSIQEQLQDSANGKTWKSRSEVDELSEFDVREDLRSWEVSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPF8</accession>
    <name>B0XPF8_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">AFUB_006330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPF8"/>
    <dbReference type="SMR" id="B0XPF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_006330"/>
    <dbReference type="HOGENOM" id="CLU_096169_0_0_1"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="PhylomeDB" id="B0XPF8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP55931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="159" mass="17714" checksum="0CF4EECFADCBD11D" modified="2008-04-08" version="1">MAPVTLSTVDDDLKEVIQHLFEIQSAVHGYLGPETQTELVRKIKNLTLALSTLSTHTKPQPPSQDDEQKGSANDPLLRDIQLPPEIIDYVDAARNPDIYTREFVELVQRGNQDLKGKKEAFASFRDVLAREMRSAMPECRGEVERVLAATGGARADTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B0XPX7</accession>
    <name>B0XPX7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_007920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XPX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_007920"/>
    <dbReference type="HOGENOM" id="CLU_036532_0_0_1"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="PhylomeDB" id="B0XPX7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="76"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP56091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="363" mass="39790" checksum="8EB2413E7F3419E1" modified="2008-04-08" version="1">MGESGLSVAGTPDAWTSAGSFIPPSIDRARLLSGESYAYYSPFPLASTGRSSQVTGDNHTITADFSTPSTSSSPSYFVLGVDEAGRGPVLGPMVYSAFYIPHTLHHSLLARDYSFNDSKVLTPGVRANLMRLLCTAGNPLHASCGWATKVLSARDISAGMMRPTSGAYNLNAQAMDATVEIIRGIVEERRVDIREVYIDTIGNPATYQQKLERIFPTLKITVAKKADALYPCVSAASVVAKVTRDMALEFCHEAVYGLQRYEAPSMEVATDSWGSGYPSDSKCVSWLRNHMDPIFGWGNECRFSWGTAKEMLELKGGTRVDWPVEEEGAAPIKDFLLTTARNAKRTEQDELREWFGRRSTEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQ10</accession>
    <name>B0XQ10_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_008300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQ10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_008300"/>
    <dbReference type="HOGENOM" id="CLU_134973_3_1_1"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="PhylomeDB" id="B0XQ10"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP56124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="79" mass="8459" checksum="EEFF5FEB9729DBC5" modified="2008-04-08" version="1">MSEHQYKFNVSMSCGGCSGAVERVLKRLDGVKSFDVNLDSQTALVTTEPTVSYETVLATIKKTGKTVNSGEADGKPMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQC4</accession>
    <name>B0XQC4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_009460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XQC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_009460"/>
    <dbReference type="HOGENOM" id="CLU_048021_1_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="317"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="317"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP56238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="399" mass="45179" checksum="825314919FFE460A" modified="2008-04-08" version="1">MSQHASRDAILSQFGIPQTNQGRDPAPRFHLWLANHTTAAKRSWLARKALPILLRFLDYSSTSTLGILVRLTSLIMPRNIIQGGGSILRYLHRSNALIRPSRVAIANGFIRRICVSMNSQLVSPTMKTFRPSVILSRPLINSFATTITPDDETETTKSTGSKTGKKNTKKRSSKAATKAKPKPRKKLTDKQKEAKKAEKMKELVKQLKKTALEPPKKLIENPWNLTIATVAKGLQARGVNGTDFIMQCSQLAQSISAEERERIATEAEANKAANAAAYEAWIQQHTPRQIRDANAARRRLNKIKNTSLRLLHDDRQVKRPRTAYLLYMLDRTAEGDFKYMTAKDISVRLTEEWKGLTATEKEKYFKQAEEDRERYRREYLEVYGEEPSTSRSTTASPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0XQF9</accession>
    <name>B0XQF9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AFUB_009810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="B0XQF9"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B0XQF9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="941"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="976"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1124"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="283"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="626"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="933"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1219"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP56273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1458" mass="160873" checksum="6CC0BEE7877779BA" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR36</accession>
    <name>B0XR36_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc metalloproteinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_012110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR36"/>
    <dbReference type="MEROPS" id="M80.A04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012110"/>
    <dbReference type="HOGENOM" id="CLU_056790_0_0_1"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="PhylomeDB" id="B0XR36"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000343">
        <property type="entry name" value="Zinc metalloproteinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="1">
        <location>
            <begin position="132"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP56500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="341" mass="38356" checksum="35D8486777008BE2" modified="2008-04-08" version="1">MTDSSTPDMTLTVHHHGKPHTFTLAPDATLQDLSSTIADTLNIPIENQKILIAPKPGMQKHPFAPTPLSTLLPLTSPKFKLTLLGTPAQEIESLNAQTAETRRRLEARAAAAAKHRTRRPAPSIAGGIHTLSSAGSNTYTFHQLLPLSYLPNPSRSLEFLARLRDDPGIRAAMAKHRFSVPLLTEMDPAEHTTSESRTLGLNRNKGEVIELRLRTDAYDGYRDYRTIRKTLCHELAHCVFSEHDRDFWDLTAQIEKEVERADWKHGGRRLTDEEFYNPGDWEREKDAAVVDERGWTGGEFVLGGLRDESSGVESRREIIARAAEERMRREREREGAQGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0XR81</accession>
    <name>B0XR81_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Avl9 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_012430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XR81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_012430"/>
    <dbReference type="HOGENOM" id="CLU_009066_0_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="PhylomeDB" id="B0XR81"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP56532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="743" mass="82865" checksum="BF4E3BB3B8D91E62" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRD2</accession>
    <name>B0XRD2_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-L-rhamnosidase A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_002060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP55511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_002060"/>
    <dbReference type="HOGENOM" id="CLU_007933_3_0_1"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="PhylomeDB" id="B0XRD2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="257"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="2">
        <location>
            <begin position="580"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP55511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="676" mass="73543" checksum="A00E8640344D13F0" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XRM4</accession>
    <name>B0XRM4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_013190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499594">
        <property type="protein sequence ID" value="EDP56608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XRM4"/>
    <dbReference type="HOGENOM" id="CLU_007577_0_0_1"/>
    <dbReference type="OrthoDB" id="5215300at2759"/>
    <dbReference type="PhylomeDB" id="B0XRM4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="340"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP56608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1055" mass="123644" checksum="320117D595988967" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B0XS33</accession>
    <name>B0XS33_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_025760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XS33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_025760"/>
    <dbReference type="HOGENOM" id="CLU_2291064_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="101" mass="11023" checksum="27D1AD7B729FA08B" modified="2008-04-08" version="1">MPKKDRGGVERGSEIYRDKAQRKTLKKSKRGKSGSGKKERGEEDEAAQSVRGWAFSTGAAQAAVLATMTLQGQQQQQAKKQQSSLIHVAFSLLILSILSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSE0</accession>
    <name>B0XSE0_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AFUB_026850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSE0"/>
    <dbReference type="SMR" id="B0XSE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_026850"/>
    <dbReference type="HOGENOM" id="CLU_078274_0_0_1"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="PhylomeDB" id="B0XSE0"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="11">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP54626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="271" mass="30035" checksum="089B9BA0526828B9" modified="2008-04-08" version="1">MAFPLPRGITPPEIAFLAEMEMVTILPRQRLEGLELLGGQVEPLLPPRRASLPLWLALLLKRQRRANILPPAWLHPEPLSLILEIETQHHEYENAFSPPPPLPGQPSVRDRNRGQRPIARARHTPDGQRYFPSPPFLPQNIAQDNAHPSEPPSLPYHWLEVGNMLLDAASDDLVDPDQIRRLLKELREVRMAKIRSGVDVLDAAATGGGGVALTGVGAMEIGESRGFVTGVVDGLRKIGASKEQARREQMAEEMANGGYDATQDDEDEMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B0XSG0</accession>
    <name>B0XSG0_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_027060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XSG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_027060"/>
    <dbReference type="HOGENOM" id="CLU_025841_2_1_1"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="PhylomeDB" id="B0XSG0"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="303"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="615" mass="69295" checksum="43F8007621DA5ACC" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTC7</accession>
    <name>B0XTC7_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AFUB_028950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_028950"/>
    <dbReference type="HOGENOM" id="CLU_021597_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B0XTC7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF228">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP54836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="444" mass="48801" checksum="0F3B8D5B8A975899" modified="2008-04-08" version="1">MADAGDRMFCHACGGVWLKNAANGLDCPHCQSDFTEIIEIPPDTEDSSSRPTNDSPPREENNQPNVNPWADHNPWANEEGYGGDDNTWRPGFSRRTYRSPDGRFTFTTTTTTLGGGGFHMGRSMDQRQMPIDPLIPVVRSLDTIFHGLADTYRHGQNQDQNQNQNQNRNATGQENETVADEHRARSESPEFRATGRLFARDADGPQPMAPPFGTLGDILELFRADFGGGMEGGGVRVMTGPNPLAMLSTLLNFDRHGDAVYSQEELDRVISQLIDQNLNRTGAPPAPQSAIRALPKKKVDEEMLGSDGKAECSICMEQVELGTEVAVLHCKHWFHYPCIEAWLSQHNTCPHCRRGIDIPQAEGTRQDPVVINDSPEPPSPERRRSSGLAQHSEQAPPTWGEHPSWNTSESNEHNQGQSSHNEGSSSGGGNGGFTGWVRSHFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTN4</accession>
    <name>B0XTN4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_029350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029350"/>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="PhylomeDB" id="B0XTN4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="103"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP54876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="414" mass="46720" checksum="10DA7886EE93194D" modified="2008-04-08" version="1">MTALNLQKILPLVPKKLSSAYFSIDPLSPQQSIYIVLSATMAPLIPSQEELDRRRIIGINPETVTNIPSTDFPGHWPGESHEWNLEKFKDGFRVEFHRNDPFESSFSLIGLDASIANAFRRILMAEVPTLAIEYVFVHNNTSVIQDEVLASRLGLIPLKGSVEGLNWMRWFKKPTEDDPESGSTPADYNTIVLRLDVECTENPNAAPGEDDPRKLYKNAHVYAKDITFHPVGRQEQFFTGDGAIQPVNPDILIAKLRPGQKIDMELHCIKGIGADHAKFSPVATATYRLMPDIKILRPIIGEDAKKFAKCFPKGVIELEPVTSREAAQKGSEYEGRAGEMKAVVRDPFKDTVSRECLRHEEFQGKVKLGRIRDHFIFNVESTGQFESDYLFLESVKVLKLKCARWKRGLADLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B0XTQ5</accession>
    <name>B0XTQ5_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_029570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XTQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_029570"/>
    <dbReference type="HOGENOM" id="CLU_1634989_0_0_1"/>
    <dbReference type="OrthoDB" id="5089392at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP54897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="162" mass="18347" checksum="4063AECC14E05809" modified="2008-04-08" version="1">MSPIEPTNPSSPGLQKRHSGSYSSQSRKSGDDYRRYSGTVNHYGLCGTPSEKALIACVMGKRAERRDLRIIFASSLVLSLRLASNQRVTVQQRHIHDTHRRTLEHTSSERQSIEVKHRKKLHQSEDLLQALRGIRDWTSGKEKQHASAVSISAFRHSVDVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUM6</accession>
    <name>B0XUM6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_020570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_020570"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="PhylomeDB" id="B0XUM6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP54011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="510" mass="55417" checksum="DA577B2AD0061BD2" modified="2008-04-08" version="1">MPFFNPFRKHDQTTFHGVVIPLSSAPSHARPESPALEKKGSPKEKPDDSSLDKAPSQENGSAASIPERSHLTIESLRAEIESDVAASGHDTAYDRKSKVINRAIQDIGMGRYQWELFCLCGFGWLADNVCALFACLGLGVGGNLPVDGALFLEFLPFASGNLLTMLSVWWPVGQLIASLIAWGLIPSYSCADDLPSCKAVGDGVACCGKDNNMGWRYFVLTMGSLTIVMFICRFFLFHLYESPKFLLARGRQDEAVAAVHGIAYKNKTKTWLTVDILNEIGGYPEENAPQTLSTKEIVQRNLSKFSLQRVRPLFATKKLGFTTVILWFCWTTIGMGYPLFNAFLPQYIKNAGGSTEASTYVTYRNYAITSIVGVPGSILACYTVDIKYIGRKGTMVISTLITGVLLFCFTASTNSNVQLVCSCLEAFFQNIMYGVLYAYTPEVFPAPSRGTGTGISSCLNRIAGLCAPLVAIYGGSSNPNSPIYASGGLILASFVAMCCLPIETMGKQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUT6</accession>
    <name>B0XUT6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_021210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002533_1_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01315">
        <property type="entry name" value="Spc7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
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        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
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        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="652"/>
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        </location>
    </feature>
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        <location>
            <begin position="686"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="986"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP54071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1559" mass="170607" checksum="C9220022A89869D9" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUV6</accession>
    <name>B0XUV6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mannan polymerase II complex ANP1 subunit Anp1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AFUB_031580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_017872_3_0_1"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="PhylomeDB" id="B0XUV6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140497">
        <property type="term" value="C:mannan polymerase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="382"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP55096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="446" mass="50528" checksum="F00B6D0B9D9B31E5" modified="2008-04-08" version="1">MNRHHAFANGYFAYPRGQSRAFSISPHREDLQLQTVRYYDLSKVQGTAKGWEKGERVLMLTPLRDASSHLPMFFSHLRNLTYPHNLIDLAFLVSDSKDDTLGMLTRMLEEVQNDPDPKMTFGEISVIQKDFGQKVQQDVESRHGFAAQAGRRKLMAQARNWLLSATLRPTHSWVYWRDADVETAPRTILEDLMRHDKDVIVPNVWRPLPDWLGGEQPYDLNSWQESETALALAETLDEDAVIVEGYAEYATWRPHLAYLRDPFGDPDMEMELDGVGGVSILAKAKVFRSGVHFPAFSFEKHAETEAFGKMAKRMGFSVIGLPHYTIWHLYEPSVDDLRHMEEMEQERKAREREEKEQAERAERMKALFVEPGPQWDIDKAFVQDSIQTEKEGPDQTKADGVTGTAEVKDVQGSASHPVAASPEPSVNAAPVAPVARGGPGETERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B0XUY4</accession>
    <name>B0XUY4_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_031860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XUY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_031860"/>
    <dbReference type="HOGENOM" id="CLU_131036_0_0_1"/>
    <dbReference type="OrthoDB" id="4349001at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002760215" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP55124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15352" checksum="4A66199A60A648B1" modified="2008-04-08" version="1">MKISNIVLCLIPSVALAAESEQKQAVALPPSAHNLPSASSPELTAPSSIEDLQSDPRIYDQFGNDITPSPDYPVVAVIPSKQRVPMSVFEGQPSEPAHGSIELRSLEASSGSTKSLRARSEGTLGQTPWIGMAIGLTCTALAAVMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XVP6</accession>
    <name>B0XVP6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cyanide hydratase</fullName>
            <shortName evidence="7">CHT</shortName>
            <ecNumber evidence="2 7">4.2.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyanide-degrading nitrilase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Formamide hydrolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_033190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>formamide = hydrogen cyanide + H2O</text>
            <dbReference type="Rhea" id="RHEA:21720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="EC" id="4.2.1.66"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer of dimers, forming left-handed helical fibers.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By cyanide.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.66" evidence="2 7"/>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP55254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XVP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_033190"/>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="PhylomeDB" id="B0XVP6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030196">
        <property type="term" value="F:cyanide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019500">
        <property type="term" value="P:cyanide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03224">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037544">
        <property type="entry name" value="CN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF4">
        <property type="entry name" value="CYANIDE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP55254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="357" mass="39955" checksum="A46AD0D8AB7285F1" modified="2008-04-08" version="1">MAPVLKKYKAAAVNAEPGWFDLEESVRRTIHWIDEAGKAGCKFIAFPELWIPGYPYWAWKVNYQESLPLLKKYRENSLPSDSEEMRRIRNAARTNKIYVSLGYSEVDLASLYTTQVLISPSGDILNHRRKIRATHVERLVFGDGTGDTTESVTQTEIGRVGHLNCWENMNPFMKAYAAALGEQVHVAAWPLYPGKETLKYPDPFTNVAEANADLVTPAYAIETGTFTLAPWQTITAEGLKLNTPPGKELEDPHIYNGHGRIFGPDGQNLVAHPDKDFQGLLLVDIDLDECHLPKALADFGGHYMRPDLIRLLVDTNRKDLVVHEDRVNGGVAYTRTVDRVGLSAPLDAMNQGPEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0XWB2</accession>
    <name>B0XWB2_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tho complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AFUB_024200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499595">
        <property type="protein sequence ID" value="EDP54364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XWB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_024200"/>
    <dbReference type="HOGENOM" id="CLU_049078_1_0_1"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="PhylomeDB" id="B0XWB2"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP54364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38074" checksum="D9D31D95ADCD801E" modified="2008-04-08" version="1">MASYGLLDQPEEDNLHKLRLLNVEEKPFKRISKRLLNPSSLVISNATILPTPPPDETEENATAAAEAEKQKRLDEWRNFREDVTLDFASFEGSIARIQFLLTSNERERERYAAEKLRILSTMQAVRENTAELRVQLEEAQRLLALRKSYDELAEKITSNRLLKPREDQQANLQKLQAEIADLENESKEYAKTWAERREQFGRIVEEGMQLRRLIRDEKEEVERREGMQEGEDGDEGDVPSKGKSSGANTPRPESDTITPSQHSQDEAGRPSAGLHAERISATTGAASPLRNVSTADQEDTNMDEGEVTGEDGSEHPDELEEGEAEPDDKTADRMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0XX87</accession>
    <name>B0XX87_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase, 2OG-Fe(II) oxygenase family family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_037200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XX87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_037200"/>
    <dbReference type="HOGENOM" id="CLU_058132_0_4_1"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="PhylomeDB" id="B0XX87"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000027">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="98"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP52554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="323" mass="36652" checksum="9E709A0A8B397D30" modified="2008-04-08" version="1">MSIKLSTILSSLFYLLPLYLFVFAPLLRQFFPEEESPLSPSTADYLFPNSANDQDADDLAPSQALNLVDDTFISIDDGITPECPLDPTYRIHFLSRTPLVIYIEGFLTTPEADHLVDISVGKYTPSIIYNGITERVDPSTRLSERALLDRDHTVRCIEDRARAFQGWRPHLYIERMWAQRYNASGHYRHHYDWAGSVARGGDRASTFMVYLDDNCTGGGTNFPRLRMPVDRRWCRFLECHGDEETLEVGDGAKDTAPRKETARARGTGEGITFKPIKGNAIFWENLRPDGTGYPETWHAALPVTSGTKVGLNIWSWYQPPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYC6</accession>
    <name>B0XYC6_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AFUB_040430</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_040430"/>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="PhylomeDB" id="B0XYC6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="101"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="186"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="400"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP52872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="501" mass="55835" checksum="52B3200515D88738" modified="2008-04-08" version="1">MSSLRLSSAFARRSLHACAPPRSAPLYSSAVRFSSLSSSTSSVFSTSSSSFSTSAAVSRPQRTLASSSLPASSRWSGVTSFRLNQSRTMATEGTKIKVKNPVVELDGDEMTRIIWQEIREKLILPYLDIDLKYYDLGIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILGGTVFREPIVIPRIPRLVPGWNKPIIIGRHAFGDQYRATDIVVPGPGKLELVYTPENGEPQAIKVYDFTGGGVAQTQYNTDDSIRGFAHSSFKMALMKGLPLYMSTKNTILKKYDGRFKDIFQEIYESTYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGFVMALKNYDGDVQSDVVAQGFGSLGLMTSTLTTPDGSAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLIQRGKLDETPDVVTFAEELERACIDVVNEEGIMTKDLALACGRKEREAWVTTKEYLAAVERRLKSNLKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B0XYK4</accession>
    <name>B0XYK4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface spherulin 4-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_041220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XYK4"/>
    <dbReference type="HOGENOM" id="CLU_1418249_0_0_1"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="PhylomeDB" id="B0XYK4"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP52950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="192" mass="21255" checksum="7CA1065739549A84" modified="2008-04-08" version="1" fragment="single">MAEKHVSNRRCLQSRRSRILLAVFVLIAILAVVIPPAVVVTLHKKNDMGPKSKVFVPLYVYPAPGAWTPLEDVISKHPDVNFTVVINPGSGPGPNALPDGNYTREIPKLASYENVRLLGYVATTYAKRNISLVRRDIETYAAWPTNSSNPALAVRGIFFDETPQQYDEDALAYLQELTDVVKNTPGLGPDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZE7</accession>
    <name>B0XZE7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_044150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044150"/>
    <dbReference type="HOGENOM" id="CLU_727569_0_0_1"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="388" mass="40601" checksum="24FCEDD90BD0314E" modified="2008-04-08" version="1">MSTSTASSTSTYTTAAEPASLSTTSSSPLPGLESTTSTITRAAAISPSSSEAVPTSTSIPGSPSASSPINSVTSASISPSATSTITSSTASSTATNQTSLLPQSSPNNVSRGALAGAIKSTRLGGSELSEAKPPQHPALHLGASASSLYAPHPADDETVRARILTLFDHARLHVDNYYSSAAASSPHNPTTSLASYESPYLPSPIATLLAKPGRHRAVLTHILVRELLQKITPGSGKGALLPACYASCPQVVNQTPETDQVLFQWRMLTAYLYQRQQGDRDVDEHASSGLAEPFVDAFTGYANPAHTRAERLQHLKSVASAAAELGRLLFAQPCAFEFVWDYPGRQGAVLVITPRVIKICDEQGRRLAVSQVMAEGTSLSPFASKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZQ1</accession>
    <name>B0XZQ1_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonribosomal peptide synthase SidD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_044830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_044830"/>
    <dbReference type="HOGENOM" id="CLU_000022_60_2_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B0XZQ1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000072">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000034">
        <property type="entry name" value="Nonribosomal peptide synthase sidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000050">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000020">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056896">
        <property type="entry name" value="SIDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24895">
        <property type="entry name" value="SIDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="764"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1557"/>
            <end position="1633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP53310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="2083" mass="228571" checksum="F95074A13907532C" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZR8</accession>
    <name>B0XZR8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AFUB_045010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045010"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B0XZR8"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="33"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP53327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="420" mass="44840" checksum="3BB2C5DD85182EA4" modified="2008-04-08" version="1">MSSNIETAPDSSQAEKNEPPKPTFPEGGLKAWMTVLSCWCVMFNTFGYMNAFGVYEAYYKNTLLRNESNSNIAWIGSLQAFFMYASGLVSGPLMDRYGPRVILVPCSIVFVLSVMLTSLCKEYYQFILAQGVLGGVFNGLTYTPTVTAVNQHFFRRRPLALGIASSGSSLAGIIIPIALNRMLNQSSLGFGWSVRILGFIMLALSVVACLAISSNAPKRRTGAPFFLEAWKQPEYTVQIIGVFLVTWALFVPMFYIPSYAQSIGIGVSLSNYLIAILNAGSLVGRILGGALANRLGRFNTLAAASAACGILILCWLRIKSRGGMVVLSVLFGFCSGIVIGLFAATIAVTAPKPNVIGSYLGMAMGVLSLASLTGTPITGAMISTYGTYDAAIIFAGVSAVLGAVIIFVARVVYAGWRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZX6</accession>
    <name>B0XZX6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnogalacturonan acetylesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_034720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034720"/>
    <dbReference type="HOGENOM" id="CLU_065859_0_0_1"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="PhylomeDB" id="B0XZX6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002758082" evidence="3">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP52308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="271" mass="28921" checksum="B63B0E5B956BE6CA" modified="2008-04-08" version="1">MKCFAFLSALALFPGTLSATIYMAGDSTMAKGGGGSGTDGKSQGKSPFARYIYNALVKTGWGLHIAPFVSGTVSNQAVAGRSARSYTREQRFQAIADVLKPGDYVVIEFGHNDGGSLRTDNGRTDCPGSGDETCTTTFNGVTETVFTFPKYLQDAAKMFQSKQAKVVISSQTPNNPWETGTFSYTPSRFVELAKLAAQRAGVDYVDHGAYVADMYKSLGKTTVDSFFPNDHTHTSSTGAEVVAQAFLKAVVCSGARLKEVLTTTNFPGKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B0XZY1</accession>
    <name>B0XZY1_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial export protein Som1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AFUB_034770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP52313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0XZY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_034770"/>
    <dbReference type="HOGENOM" id="CLU_142986_2_0_1"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="PhylomeDB" id="B0XZY1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP52313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11916" checksum="9B439A943A1BFF64" modified="2008-04-08" version="1">MAPLVPVFSAESLPEHVNTVTRNFQERRRKGGPVDLENCKLLEMVQYSCNPPQDGIPKPGVVTCKPIVRLFRRCAGGLTVETTAWEPIRLAEEEAKRNRAAEEATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y021</accession>
    <name>B0Y021_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AFUB_045340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y021"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045340"/>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="PhylomeDB" id="B0Y021"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="363"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP53359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="714" mass="79519" checksum="92226465DF3D8271" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y059</accession>
    <name>B0Y059_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AFUB_045720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y059"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045720"/>
    <dbReference type="HOGENOM" id="CLU_1503115_0_0_1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="PhylomeDB" id="B0Y059"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP53397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="179" mass="19645" checksum="59B7176C307A41F2" modified="2008-04-08" version="1">MFFTLLAISGFFRIIRPQEVQKGLVAGFTVVIFTFFYGIGAGSVPFTFSTEVFPLTYRVGLMMQVPDIESVEVGMSFSVMVNFLGLSLLVLFVPRLTTILSPNGPSARKARLLGQSNLLFLFSGLNALAFVLVFFLVPSGTAQISLEEMNAICMDCSWLPLSCSIQRPLCMHLSISLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0E4</accession>
    <name>B0Y0E4_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_045890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499596">
        <property type="protein sequence ID" value="EDP53414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0E4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_045890"/>
    <dbReference type="HOGENOM" id="CLU_1937664_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP53414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="130" mass="14264" checksum="A27728E0DF47BD65" modified="2008-04-08" version="1">MTSIEEGGIVFHPKENNNEDVKVAYKEYGDMKMESTAQDLAESIADDVKQNMTAALESVSETLSQAMANANRLCLPAAGTFFMKDPVFNEGGDLLVKLEYDGADPPPPPSKGKYRFRPPMVTASVRRMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0M7</accession>
    <name>B0Y0M7_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AFUB_057860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_057860"/>
    <dbReference type="HOGENOM" id="CLU_035117_1_2_1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0M7"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="173"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="314"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP51768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="435" mass="46272" checksum="0184D72B5B19F76E" modified="2008-04-08" version="1">MSKPTIGFVGLGAMGFGMATNLVREGYPVVGFDVFPASVQRFQSQGGIPASSLRESAEGKDFYICMVASAPQVQSVLFGDDGVVQYLPKNATLFLCSTVPASYAQSVAAELQSRGRADIRFIDCPVSGGAKRAADGTLSIMAGASEEALNSGREILQVMSDQNKLYLVPGGVGAGSNMKMVHQVLAGIHILGASEAMGFAAQLGLDAKTTAEKIIGSEAWTWMHENRLQRMVEEDWNPGASALTIILKDVGIITTSARQHHFPTPLCSTAEQVYLSALLQGYGPKDDSAMVRQYYPKPLAEVTCTAEDPSAALQLVLDLMLGVNLVAAAEAIAFARYLDVDLAMFHRLVSDAAGASKVFIHKGLEMIEGRIGDKAPEGSQTLDEAVAQMEKVVQKARDLHCPLHLGNAALEKLLMARRHGLGGEASTSVIKLFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0Q9</accession>
    <name>B0Y0Q9_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stress response RCI peptide, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AFUB_058210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0Q9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058210"/>
    <dbReference type="HOGENOM" id="CLU_107649_0_0_1"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0Q9"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP51800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="163" mass="17909" checksum="AB722E13E80AAC9F" modified="2008-04-08" version="1">MCGSDIFLGILAIFFPPVAVWIKVGICTADSIINLALCCLGYVPGLLHAWYIILKYPEPDYDDPNYEPIPGHAGRRQDTESGRVTYYYVSHQPIQHPSQRSYGTVTPQNQPAPSPAPKPQQQAPKPHHEEGQGGSSDHAQGDSRPPPTYAEAVKGDHKVQTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y0R6</accession>
    <name>B0Y0R6_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AFUB_058280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y0R6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_058280"/>
    <dbReference type="HOGENOM" id="CLU_002863_0_0_1"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="PhylomeDB" id="B0Y0R6"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000217">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000610">
        <property type="entry name" value="Pentatricopeptide repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000768">
        <property type="entry name" value="Pentatricopeptide repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="3">
        <location>
            <begin position="485"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP51807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="1272" mass="139440" checksum="E4732AA072000149" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y123</accession>
    <name>B0Y123_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TOR signalling pathway regulator (TapA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AFUB_059340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y123"/>
    <dbReference type="HOGENOM" id="CLU_041824_2_0_1"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="PhylomeDB" id="B0Y123"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.540:FF:000005">
        <property type="entry name" value="TOR signalling pathway regulator (TapA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP51914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="358" mass="41082" checksum="3B7179A52EEB339F" modified="2008-04-08" version="1">MEQPQSLRSLFTAAKAEKASLESRSDSNSDSYREDVNATIAKFEECQRLVAQLSLFSSNEPLEDIATGDIQYLTVDYLLADILQRTYTSDRESTIRRALELYEKYLSRLDDYGLLNDNEKKLHERYISNPSSFSLTPTNDAATRREVKLSRFREEKELKQRLESQQYFSNNQSRLQSDDEDVRKLHLAEINLYTHQAFQSMDLLSQELSMLSAIRSNPPNPAQPPQDDPRRRNNNFESGYSERLDPPLSQLLRGGKSGPILSKEGKPLQPFTLLDRRTQLQQGVFRPGHNLPTMTIDEYLEEEKRRGGIIEGGEKSGMKEEVDEDDMDKADEETMKARAWDEFKEANPRGSGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y136</accession>
    <name>B0Y136_ASPFC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AFUB_059470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP51927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y136"/>
    <dbReference type="SMR" id="B0Y136"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_059470"/>
    <dbReference type="HOGENOM" id="CLU_007736_0_0_1"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="PhylomeDB" id="B0Y136"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000349">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="17"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="180"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="395"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="758"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP51927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="839" mass="97187" checksum="B59A735A97F6F52A" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y299</accession>
    <name>B0Y299_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell-associated beta-galactosidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AFUB_061780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10)</name>
        <name type="synonym">Neosartorya fumigata</name>
        <dbReference type="NCBI Taxonomy" id="451804"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Fumigati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2008" name="PLoS Genet." volume="4" first="E1000046" last="E1000046">
            <title>Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.</title>
            <authorList>
                <person name="Fedorova N.D."/>
                <person name="Khaldi N."/>
                <person name="Joardar V.S."/>
                <person name="Maiti R."/>
                <person name="Amedeo P."/>
                <person name="Anderson M.J."/>
                <person name="Crabtree J."/>
                <person name="Silva J.C."/>
                <person name="Badger J.H."/>
                <person name="Albarraq A."/>
                <person name="Angiuoli S."/>
                <person name="Bussey H."/>
                <person name="Bowyer P."/>
                <person name="Cotty P.J."/>
                <person name="Dyer P.S."/>
                <person name="Egan A."/>
                <person name="Galens K."/>
                <person name="Fraser-Liggett C.M."/>
                <person name="Haas B.J."/>
                <person name="Inman J.M."/>
                <person name="Kent R."/>
                <person name="Lemieux S."/>
                <person name="Malavazi I."/>
                <person name="Orvis J."/>
                <person name="Roemer T."/>
                <person name="Ronning C.M."/>
                <person name="Sundaram J.P."/>
                <person name="Sutton G."/>
                <person name="Turner G."/>
                <person name="Venter J.C."/>
                <person name="White O.R."/>
                <person name="Whitty B.R."/>
                <person name="Youngman P."/>
                <person name="Wolfe K.H."/>
                <person name="Goldman G.H."/>
                <person name="Wortman J.R."/>
                <person name="Jiang B."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="18404212"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 144.89 / FGSC A1163 / CEA10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DS499597">
        <property type="protein sequence ID" value="EDP52141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B0Y299"/>
    <dbReference type="VEuPathDB" id="FungiDB:AFUB_061780"/>
    <dbReference type="HOGENOM" id="CLU_006501_3_0_1"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="PhylomeDB" id="B0Y299"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000001699">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="9">
        <location>
            <begin position="102"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="6">
        <location>
            <begin position="230"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="644"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="8">
        <location>
            <begin position="725"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP52141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001699"/>
        </source>
    </evidence>
    <sequence length="976" mass="109247" checksum="1557D348B2FE0BED" modified="2008-04-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-08" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B0Y2D8</accession>
    <name>B0Y2D8_ASPFC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone acetylase complex subunit Paf400, putative</fullName>
    